Literatures

Primary Site >> Colorectal Cancer

Gene >> NR1I2

1.
Journal:	J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31.
Title:	Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.
Author:	Geick, A\|Eichelbaum, M\|Burk, O
PMID:	11297522

2.
Journal:	J Pharm Pharmacol. 2003 Jan;55(1):59-66.
Title:	Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines.
Author:	Pfrunder, Arabelle\|Gutmann, Heike\|Beglinger, Christoph\|Drewe, Jurgen
PMID:	12625868

3.
Journal:	Biochem Biophys Res Commun. 2003 Jun 20;306(1):116-20.
Title:	Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA.
Author:	Takara, Kohji\|Takagi, Kentaro\|Tsujimoto, Masayuki\|Ohnishi, Noriaki\|Yokoyama, Teruyoshi
PMID:	12788075

4.
Journal:	Drug Metab Dispos. 2004 Aug;32(8):779-82.
Title:	Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor.
Author:	Mitin, Tim\|Von Moltke, Lisa L\|Court, Michael H\|Greenblatt, David J
PMID:	15258100

5.
Journal:	Hepatology. 2005 Jan;41(1):168-76.
Title:	Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice.
Author:	Uppal, Hirdesh\|Toma, David\|Saini, Simrat P S\|Ren, Songrong\|Jones, Thomas J\|Xie, Wen
PMID:	15619241

6.
Journal:	Clin Pharmacol Ther. 2006 May;79(5):449-60. Epub 2006 Apr 11.
Title:	Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans.
Author:	Becquemont, Laurent\|Glaeser, Hartmut\|Drescher, Siegfried\|Hitzl, Monika\|Simon, Nicolas\|Murdter, Thomas E\|Heinkele, Georg\|Hofmann, Ute\|Schaefer, Christian\|Burk, Oliver\|Verstuyft, Celine\|Eichelbaum, Michel\|Fromm, Martin F
PMID:	16678547

7.
Journal:	Inflamm Bowel Dis. 2007 Jun;13(6):710-20.
Title:	Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels.
Author:	Blokzijl, Hans\|Vander Borght, Sara\|Bok, Lisette I H\|Libbrecht, Louis\|Geuken, Mariska\|van den Heuvel, Fiona A J\|Dijkstra, Gerard\|Roskams, Tania A D\|Moshage, Han\|Jansen, Peter L M\|Faber, Klaas Nico
PMID:	17262809

8.
Journal:	Eur J Clin Pharmacol. 2007 Jun;63(6):547-54. Epub 2007 Apr 3.
Title:	Identification of NR1I2 genetic variation using resequencing.
Author:	King, Cristi R\|Xiao, Ming\|Yu, Jinsheng\|Minton, Matthew R\|Addleman, Nicholas J\|Van Booven, Derek J\|Kwok, Pui-Yan\|McLeod, Howard L\|Marsh, Sharon
PMID:	17404718

9.
Journal:	Mol Endocrinol. 2008 Apr;22(4):868-80. Epub 2007 Dec 20.
Title:	The antiapoptotic role of pregnane X receptor in human colon cancer cells.
Author:	Zhou, Jie\|Liu, Mingjie\|Zhai, Yonggong\|Xie, Wen
PMID:	18096695

10.
Journal:	Drug Metab Dispos. 2008 May;36(5):946-54.
Title:	Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.
Author:	Sane, Rucha S\|Buckley, Donna J\|Buckley, Arthur R\|Nallani, Srikanth C\|Desai, Pankaj B
PMID:	18299335

11.
Journal:	J Intern Med. 2008 Jun;263(6):613-9.
Title:	A gut feeling of the PXR, PPAR and NF-kappaB connection.
Author:	Wahli, W
PMID:	18479261

12.
Journal:	Anticancer Agents Med Chem. 2008 Jun;8(5):540-63.
Title:	Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential.
Author:	Zimber, Amazia\|Gespach, Christian
PMID:	18537536

13.
Journal:	Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71.
Title:	PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide.
Author:	Zimmermann, Christian\|van Waterschoot, Robert A B\|Harmsen, Stefan\|Maier, Angelika\|Gutmann, Heike\|Schinkel, Alfred H
PMID:	19138736

14.
Journal:	J Gastrointest Surg. 2009 Oct;13(10):1831-8.
Title:	Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance.
Author:	Jiang, Heng\|Chen, Keli\|He, Jianming\|Pan, Feng\|Li, Jianjun\|Chen, Jianfang\|Chen, Wensheng\|Liang, Houjie
PMID:	19593667

15.
Journal:	Drug Metab Dispos. 2009 Jul;37(7):1539-47.
Title:	Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.
Author:	Xu, Chenshu\|Wang, Xinkun\|Staudinger, Jeff L
PMID:	19359405

16.
Journal:	Clin Rev Allergy Immunol. 2009 Feb;36(1):52-61.
Title:	Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators?
Author:	Beuers, Ulrich\|Kullak-Ublick, Gerd A\|Pusl, Thomas\|Rauws, Erik R\|Rust, Christian
PMID:	18751930

17.
Journal:	Cancer Chemother Pharmacol. 2010 Sep;66(4):765-71.
Title:	PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line.
Author:	Harmsen, Stefan\|Meijerman, I\|Febus, C L\|Maas-Bakker, R F\|Beijnen, J H\|Schellens, J H M
PMID:	20041327

18.
Journal:	Mol Cancer. 2010 Mar 2;9:46.
Title:	Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.
Author:	Raynal, Caroline\|Pascussi, Jean-Marc\|Leguelinel, Geraldine\|Breuker, Cyril\|Kantar, Jovana\|Lallemant, Benjamin\|Poujol, Sylvain\|Bonnans, Caroline\|Joubert, Dominique\|Hollande, Frederic\|Lumbroso, Serge\|Brouillet, Jean-Paul\|Evrard, Alexandre
PMID:	20196838

19.
Journal:	Br J Cancer. 2010 Jun 8;102(12):1753-61.
Title:	Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.
Author:	Ouyang, N\|Ke, S\|Eagleton, N\|Xie, Y\|Chen, G\|Laffins, B\|Yao, H\|Zhou, B\|Tian, Y
PMID:	20531417

20.
Journal:	BMC Cancer. 2010 Sep 13;10:484.
Title:	Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes.
Author:	Andersen, Vibeke\|Christensen, Jane\|Overvad, Kim\|Tjonneland, Anne\|Vogel, Ulla
PMID:	20836841

21.
Journal:	J Am Coll Nutr. 2011 Aug;30(4):265-73.
Title:	Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line.
Author:	Kuan, Cheng-Yi\|Walker, Terry H\|Luo, Pengju G\|Chen, Chin-Fu
PMID:	21917707

22.
Journal:	PLoS One. 2011;6(7):e22978.
Title:	Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.
Author:	Mencarelli, Andrea\|Distrutti, Eleonora\|Renga, Barbara\|D'Amore, Claudio\|Cipriani, Sabrina\|Palladino, Giuseppe\|Donini, Annibale\|Ricci, Patrizia\|Fiorucci, Stefano
PMID:	21829567

23.
Journal:	J Clin Invest. 2011 Aug;121(8):3220-32.
Title:	Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.
Author:	Wang, Hongwei\|Venkatesh, Madhukumar\|Li, Hao\|Goetz, Regina\|Mukherjee, Subhajit\|Biswas, Arunima\|Zhu, Liang\|Kaubisch, Andreas\|Wang, Lei\|Pullman, James\|Whitney, Kathleen\|Kuro-o, Makoto\|Roig, Andres I\|Shay, Jerry W\|Mohammadi, Moosa\|Mani, Sridhar
PMID:	21747170

24.
Journal:	Endocr Relat Cancer. 2011 Jun 8;18(3):371-84.
Title:	Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes.
Author:	Rudolph, Anja\|Sainz, Juan\|Hein, Rebecca\|Hoffmeister, Michael\|Frank, Bernd\|Forsti, Asta\|Brenner, Hermann\|Hemminki, Kari\|Chang-Claude, Jenny
PMID:	21490239

25.
Journal:	Mol Pharmacol. 2011 Jul;80(1):124-35.
Title:	In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation.
Author:	Venkatesh, Madhukumar\|Wang, Hongwei\|Cayer, Julie\|Leroux, Melissa\|Salvail, Dany\|Das, Bhaskar\|Wrobel, Jay E\|Mani, Sridhar
PMID:	21464197

26.
Journal:	BMC Cancer. 2011 Feb 22;11:81.
Title:	Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.
Author:	Habano, Wataru\|Gamo, Toshie\|Terashima, Jun\|Sugai, Tamotsu\|Otsuka, Koki\|Wakabayashi, Go\|Ozawa, Shogo
PMID:	21342487

27.
Journal:	Endocr Relat Cancer. 2011 Mar 9;18(2):265-76.
Title:	Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk.
Author:	Sainz, J\|Rudolph, A\|Hein, R\|Hoffmeister, M\|Buch, S\|von Schonfels, W\|Hampe, J\|Schafmayer, C\|Volzke, H\|Frank, B\|Brenner, H\|Forsti, A\|Hemminki, K\|Chang-Claude, J
PMID:	21317201

28.
Journal:	Mol Cancer. 2011 Jul 6;10:80.
Title:	Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.
Author:	Basseville, Agnes\|Preisser, Laurence\|de Carne Trecesson, Sophie\|Boisdron-Celle, Michele\|Gamelin, Erick\|Coqueret, Olivier\|Morel, Alain
PMID:	21733184

29.
Journal:	J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):41-7.
Title:	Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19.
Author:	Miyata, Masaaki\|Hata, Tatsuya\|Yamakawa, Hiroki\|Kagawa, Tatehiro\|Yoshinari, Kouichi\|Yamazoe, Yasushi
PMID:	22561792

30.
Journal:	Mol Pharm. 2012 Sep 4;9(9):2565-76.
Title:	Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins.
Author:	Herraez, Elisa\|Gonzalez-Sanchez, Ester\|Vaquero, Javier\|Romero, Marta R\|Serrano, Maria A\|Marin, Jose J G\|Briz, Oscar
PMID:	22800197

31.
Journal:	PLoS One. 2012;7(7):e36075.
Title:	Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.
Author:	Dou, Wei\|Mukherjee, Subhajit\|Li, Hao\|Venkatesh, Madhukumar\|Wang, Hongwei\|Kortagere, Sandhya\|Peleg, Ariel\|Chilimuri, Sridhar S\|Wang, Zheng-Tao\|Feng, Ying\|Fearon, Eric R\|Mani, Sridhar
PMID:	22815676

32.
Journal:	Carcinogenesis. 2012 Dec;33(12):2311-9.
Title:	Splice isoforms as therapeutic targets for colorectal cancer.
Author:	Miura, Koh\|Fujibuchi, Wataru\|Unno, Michiaki
PMID:	23118106

33.
Journal:	Zhonghua Yi Xue Za Zhi. 2013 Feb 26;93(8):614-8.
Title:	[Effects of autophagy modulator on autophagy and uridine 5'-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane].
Author:	Wang, Min\|Chen, Shuo\|Qing, Ying\|Wu, Dong\|Lin, Ying-min\|Chen, Jian\|Li, Yan-qing
PMID:	23663345

34.
Journal:	J Pharm Sci. 2013 Dec;102(12):4444-54.
Title:	Bitter melon extracts enhance the activity of chemotherapeutic agents through the modulation of multiple drug resistance.
Author:	Kwatra, Deep\|Venugopal, Anand\|Standing, David\|Ponnurangam, Sivapriya\|Dhar, Animesh\|Mitra, Ashim\|Anant, Shrikant
PMID:	24129966

35.
Journal:	J Pharmacol Exp Ther. 2014 Dec;351(3):559-67.
Title:	Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.
Author:	Cheng, Jie\|Fang, Zhong-Ze\|Nagaoka, Kenjiro\|Okamoto, Minoru\|Qu, Aijuan\|Tanaka, Naoki\|Kimura, Shioko\|Gonzalez, Frank J
PMID:	25277138

36.
Journal:	Oncol Lett. 2014 Dec;8(6):2407-2416.
Title:	Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.
Author:	Wang, Min\|Zhu, Jing-Yu\|Chen, Shuo\|Qing, Ying\|Wu, Dong\|Lin, Ying-Min\|Luo, Ji-Zhuang\|Han, Wei\|Li, Yan-Qing
PMID:	25364403

37.
Journal:	Cell Biosci. 2014 Apr 1;4(1):17.
Title:	Tissue-specific regulation of pregnane X receptor in cancer development and therapy.
Author:	Robbins, Delira\|Chen, Taosheng
PMID:	24690092

38.
Journal:	Genes Nutr. 2015 Jan;10(1):448.
Title:	Interactions between meat intake and genetic variation in relation to colorectal cancer.
Author:	Andersen, Vibeke\|Vogel, Ulla
PMID:	25491747

39.
Journal:	Bioorg Med Chem. 2015 Feb 1;23(3):602-11.
Title:	IND-2, a pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells.
Author:	Karthikeyan, Chandrabose\|Lee, Crystal\|Moore, Joshua\|Mittal, Roopali\|Suswam, Esther A\|Abbott, Kodye L\|Pondugula, Satyanarayana R\|Manne, Upender\|Narayanan, Narayanan K\|Trivedi, Piyush\|Tiwari, Amit K
PMID:	25537531

40.
Journal:	Cancer Epidemiol. 2015 Dec;39(6):972-7.
Title:	Functional variants inPXRare associated with colorectal cancer susceptibility in Chinese populations.
Author:	Ni, Haizhen\|Su, Bofeng\|Pan, Lemen\|Li, Xueyan\|Zhu, Xixia\|Chen, Xiangjian
PMID:	26547791

41.
Journal:	Clin Pharmacokinet. 2016 Sep;55(9):1145-57.
Title:	Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients.
Author:	Mbatchi, Litaty Cephanoee\|Robert, Jacques\|Ychou, Marc\|Boyer, Jean-Christophe\|Del Rio, Maguy\|Gassiot, Matthieu\|Thomas, Fabienne\|Tubiana, Nicole\|Evrard, Alexandre
PMID:	27116457

42.
Journal:	Int J Oncol. 2016 Aug;49(2):639-45.
Title:	Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway.
Author:	Esposito, Giuseppe\|Gigli, Stefano\|Seguella, Luisa\|Nobile, Nicola\|D'Alessandro, Alessandra\|Pesce, Marcella\|Capoccia, Elena\|Steardo, Luca\|Cirillo, Carla\|Cuomo, Rosario\|Sarnelli, Giovanni
PMID:	27279570

43.
Journal:	Oncotarget. 2016 Aug 2;7(31):49848-49858.
Title:	Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization.
Author:	Wang, Hao\|Huang, Cheng\|Zhao, Liang\|Zhang, Huan\|Yang, Jing Mo\|Luo, Peng\|Zhan, Bing-Xiang\|Pan, Qing\|Li, Jun\|Wang, Bao-Long
PMID:	27409663

44.
Journal:	Oncotarget. 2016 Aug 30;7(35):56558-56573.
Title:	Pregnane X-receptor promotes stem cell-mediated colon cancer relapse.
Author:	Planque, Chris\|Rajabi, Fatemeh\|Grillet, Fanny\|Finetti, Pascal\|Bertucci, Francois\|Gironella, Meritxell\|Lozano, Juan Jose\|Beucher, Bertrand\|Giraud, Julie\|Garambois, Veronique\|Vincent, Charles\|Brown, Daniel\|Caillo, Ludovic\|Kantar, Jovana\|Pelegrin, Andre\|Prud
PMID:	27448961

45.
Journal:	Cell Death Discov. 2016 Apr 18;2:16023.
Title:	Human pregnane X receptor compromises the function of p53 and promotes malignant transformation.
Author:	Robbins, D\|Cherian, M\|Wu, J\|Chen, T
PMID:	27547448

46.
Journal:	Mol Cancer. 2017 Mar 29;16(1):71.
Title:	Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer.
Author:	Dong, Yan\|Wang, Zhe\|Xie, Gan-Feng\|Li, Chong\|Zuo, Wen-Wei\|Meng, Gang\|Xu, Cheng-Ping\|Li, Jian-Jun
PMID:	28356150