Primary Site >> Colorectal Cancer
Gene >> NR1I2
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Ref: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. PMID: 11297522 |
Ref: Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines. PMID: 12625868 Ref: Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA. PMID: 12788075 |
Ref: Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor. PMID: 15258100 |
Ref: Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. PMID: 15619241 |
Ref: Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. PMID: 16678547 |
Ref: Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. PMID: 17262809 Ref: Identification of NR1I2 genetic variation using resequencing. PMID: 17404718 |
Ref: The antiapoptotic role of pregnane X receptor in human colon cancer cells. PMID: 18096695 Ref: Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells. PMID: 18299335 Ref: A gut feeling of the PXR, PPAR and NF-kappaB connection. PMID: 18479261 Ref: Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential. PMID: 18537536 |
Ref: Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? PMID: 18751930 Ref: PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. PMID: 19138736 Ref: Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor. PMID: 19359405 Ref: Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance. PMID: 19593667 |
Ref: PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line. PMID: 20041327 Ref: Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. PMID: 20196838 Ref: Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. PMID: 20531417 Ref: Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. PMID: 20836841 |
Ref: Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. PMID: 21317201 Ref: Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells. PMID: 21342487 Ref: In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation. PMID: 21464197 Ref: Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes. PMID: 21490239 Ref: Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells. PMID: 21733184 Ref: Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. PMID: 21747170 Ref: Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. PMID: 21829567 Ref: Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. PMID: 21917707 |
Ref: Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19. PMID: 22561792 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. PMID: 22815676 Ref: Splice isoforms as therapeutic targets for colorectal cancer. PMID: 23118106 |
Ref: [Effects of autophagy modulator on autophagy and uridine 5'-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane]. PMID: 23663345 Ref: Bitter melon extracts enhance the activity of chemotherapeutic agents through the modulation of multiple drug resistance. PMID: 24129966 |
Ref: Tissue-specific regulation of pregnane X receptor in cancer development and therapy. PMID: 24690092 Ref: Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. PMID: 25277138 Ref: Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. PMID: 25364403 |
Ref: Interactions between meat intake and genetic variation in relation to colorectal cancer. PMID: 25491747 Ref: IND-2, a pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells. PMID: 25537531 Ref: Functional variants inPXRare associated with colorectal cancer susceptibility in Chinese populations. PMID: 26547791 |
Ref: Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients. PMID: 27116457 Ref: Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway. PMID: 27279570 Ref: Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization. PMID: 27409663 Ref: Pregnane X-receptor promotes stem cell-mediated colon cancer relapse. PMID: 27448961 Ref: Human pregnane X receptor compromises the function of p53 and promotes malignant transformation. PMID: 27547448 |
Ref: Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer. PMID: 28356150 |