Primary Site >> Colorectal Cancer
Gene >> NR1H4
| 1. | |||||||||||
| Journal: | Electrophoresis. 2003 Nov;24(21):3748-54. | ||||||||||
| Title: | Evaluation of RNA messengers involved in lipid trafficking of human intestinal cells by reverse-transcription polymerase chain reaction with competimer technology and microchip electrophoresis. | ||||||||||
| Author: | Cantafora, Alfredo|Blotta, Ida|Rivabene, Roberto|Pisciotta, Livia|Bertolini, Stefano | ||||||||||
| PMID: | 14613201 | ||||||||||
| 2. | |||||||||||
| Journal: | Dig Dis Sci. 2004 Jun;49(6):982-9. | ||||||||||
| Title: | The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. | ||||||||||
| Author: | De Gottardi, Andrea|Touri, Fethi|Maurer, Christoph A|Perez, Anne|Maurhofer, Olivier|Ventre, Giovanni|Bentzen, Craig L|Niesor, Eric J|Dufour, Jean-Francois | ||||||||||
| PMID: | 15309887 | ||||||||||
| 3. | |||||||||||
| Journal: | Anticancer Agents Med Chem. 2008 Jun;8(5):540-63. | ||||||||||
| Title: | Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential. | ||||||||||
| Author: | Zimber, Amazia|Gespach, Christian | ||||||||||
| PMID: | 18537536 | ||||||||||
| 4. | |||||||||||
| Journal: | Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G996-G1003. | ||||||||||
| Title: | beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. | ||||||||||
| Author: | Sinha, Jyoti|Chen, Frank|Miloh, Tamir|Burns, Robert C|Yu, Zhisheng|Shneider, Benjamin L | ||||||||||
| PMID: | 18772362 | ||||||||||
| 5. | |||||||||||
| Journal: | Cancer Res. 2008 Dec 1;68(23):9589-94. | ||||||||||
| Title: | Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. | ||||||||||
| Author: | Modica, Salvatore|Murzilli, Stefania|Salvatore, Lorena|Schmidt, Daniel R|Moschetta, Antonio | ||||||||||
| PMID: | 19047134 | ||||||||||
| 6. | |||||||||||
| Journal: | Clin Rev Allergy Immunol. 2009 Feb;36(1):52-61. | ||||||||||
| Title: | Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? | ||||||||||
| Author: | Beuers, Ulrich|Kullak-Ublick, Gerd A|Pusl, Thomas|Rauws, Erik R|Rust, Christian | ||||||||||
| PMID: | 18751930 | ||||||||||
| 7. | |||||||||||
| Journal: | J Pharmacol Exp Ther. 2009 Feb;328(2):469-77. | ||||||||||
| Title: | Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. | ||||||||||
| Author: | Maran, Rengasamy R M|Thomas, Ann|Roth, Megan|Sheng, Zhonghua|Esterly, Noriko|Pinson, David|Gao, Xin|Zhang, Yawei|Ganapathy, Vadivel|Gonzalez, Frank J|Guo, Grace L | ||||||||||
| PMID: | 18981289 | ||||||||||
| 8. | |||||||||||
| Journal: | Carcinogenesis. 2010 Jun;31(6):1100-9. | ||||||||||
| Title: | Sodium taurocholate inhibits intestinal adenoma formation in APCMin/+ mice, potentially through activation of the farnesoid X receptor. | ||||||||||
| Author: | Smith, Darcey L H|Keshavan, Pavitra|Avissar, Uri|Ahmed, Kashif|Zucker, Stephen D | ||||||||||
| PMID: | 20194350 | ||||||||||
| 9. | |||||||||||
| Journal: | Biochim Biophys Acta. 2010 Jul;1801(7):683-92. | ||||||||||
| Title: | Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. | ||||||||||
| Author: | Gadaleta, Raffaella M|van Mil, Saskia W C|Oldenburg, Bas|Siersema, Peter D|Klomp, Leo W J|van Erpecum, Karel J | ||||||||||
| PMID: | 20399894 | ||||||||||
| 10. | |||||||||||
| Journal: | Pharmacol Res. 2011 Apr;63(4):259-65. | ||||||||||
| Title: | Tissue-specific function of farnesoid X receptor in liver and intestine. | ||||||||||
| Author: | Zhu, Yan|Li, Fei|Guo, Grace L | ||||||||||
| PMID: | 21211565 | ||||||||||
| 11. | |||||||||||
| Journal: | Biochim Biophys Acta. 2011 Aug;1812(8):851-8. | ||||||||||
| Title: | Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappaB signaling in the intestine. | ||||||||||
| Author: | Gadaleta, Raffaella M|Oldenburg, Bas|Willemsen, Ellen C L|Spit, Maureen|Murzilli, Stefania|Salvatore, Lorena|Klomp, Leo W J|Siersema, Peter D|van Erpecum, Karel J|van Mil, Saskia W C | ||||||||||
| PMID: | 21540105 | ||||||||||
| 12. | |||||||||||
| Journal: | PLoS One. 2011;6(7):e22978. | ||||||||||
| Title: | Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. | ||||||||||
| Author: | Mencarelli, Andrea|Distrutti, Eleonora|Renga, Barbara|D'Amore, Claudio|Cipriani, Sabrina|Palladino, Giuseppe|Donini, Annibale|Ricci, Patrizia|Fiorucci, Stefano | ||||||||||
| PMID: | 21829567 | ||||||||||
| 13. | |||||||||||
| Journal: | PLoS One. 2012;7(10):e48461. | ||||||||||
| Title: | Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis. | ||||||||||
| Author: | Peng, Zhongsheng|Raufman, Jean-Pierre|Xie, Guofeng | ||||||||||
| PMID: | 23119029 | ||||||||||
| 14. | |||||||||||
| Journal: | PLoS One. 2012;7(10):e43044. | ||||||||||
| Title: | FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. | ||||||||||
| Author: | Deuschle, Ulrich|Schuler, Julia|Schulz, Andreas|Schluter, Thomas|Kinzel, Olaf|Abel, Ulrich|Kremoser, Claus | ||||||||||
| PMID: | 23056173 | ||||||||||
| 15. | |||||||||||
| Journal: | Pharmacol Res. 2012 Nov;66(5):419-27. | ||||||||||
| Title: | Up-regulation of FXR isoforms is not required for stimulation of the expression of genes involved in the lack of response of colon cancer to chemotherapy. | ||||||||||
| Author: | Martinez-Becerra, P|Monte, I|Romero, M R|Serrano, M A|Vaquero, J|Macias, R I R|Del Rio, A|Grane-Boladeras, N|Jimenez, F|San-Martin, F Gonzalez|Pastor-Anglada, M|Marin, J J G | ||||||||||
| PMID: | 22898327 | ||||||||||
| 16. | |||||||||||
| Journal: | Histol Histopathol. 2012 Jul;27(7):835-53. | ||||||||||
| Title: | Farnesoid X Receptor (FXR) from normal to malignant state. | ||||||||||
| Author: | Koutsounas, Ioannis|Giaginis, Constantinos|Theocharis, Stamatios | ||||||||||
| PMID: | 22648540 | ||||||||||
| 17. | |||||||||||
| Journal: | J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):41-7. | ||||||||||
| Title: | Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19. | ||||||||||
| Author: | Miyata, Masaaki|Hata, Tatsuya|Yamakawa, Hiroki|Kagawa, Tatehiro|Yoshinari, Kouichi|Yamazoe, Yasushi | ||||||||||
| PMID: | 22561792 | ||||||||||
| 18. | |||||||||||
| Journal: | Int J Cancer. 2012 May 15;130(10):2232-9. | ||||||||||
| Title: | Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis. | ||||||||||
| Author: | Lax, Sigurd|Schauer, Georg|Prein, Kurt|Kapitan, Magdalena|Silbert, Dagmar|Berghold, Andrea|Berger, Anton|Trauner, Michael | ||||||||||
| PMID: | 21780109 | ||||||||||
| 19. | |||||||||||
| Journal: | Mol Pharm. 2012 Sep 4;9(9):2565-76. | ||||||||||
| Title: | Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. | ||||||||||
| Author: | Herraez, Elisa|Gonzalez-Sanchez, Ester|Vaquero, Javier|Romero, Marta R|Serrano, Maria A|Marin, Jose J G|Briz, Oscar | ||||||||||
| PMID: | 22800197 | ||||||||||
| 20. | |||||||||||
| Journal: | Inflamm Bowel Dis. 2013 Feb;19(2):275-82. | ||||||||||
| Title: | Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia. | ||||||||||
| Author: | Torres, Joana|Bao, Xiuliang|Iuga, Alina C|Chen, Anli|Harpaz, Noam|Ullman, Thomas|Cohen, Benjamin L|Pineton de Chambrun, Guillaume|Asciutti, Stefania|Odin, Joseph A|Sachar, David B|Gaskins, H Rex|Setchell, Kenneth|Colombel, Jean-Frederic|Itzkowitz, Steven | ||||||||||
| PMID: | 23348121 | ||||||||||
| 21. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2013 Nov;6(11):1171-81. | ||||||||||
| Title: | Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients. | ||||||||||
| Author: | Leclerc, Daniel|Levesque, Nancy|Cao, Yuanhang|Deng, Liyuan|Wu, Qing|Powell, Jasmine|Sapienza, Carmen|Rozen, Rima | ||||||||||
| PMID: | 24169962 | ||||||||||
| 22. | |||||||||||
| Journal: | Am J Physiol Gastrointest Liver Physiol. 2014 Jan 1;306(1):G48-58. | ||||||||||
| Title: | FXR silencing in human colon cancer by DNA methylation and KRAS signaling. | ||||||||||
| Author: | Bailey, Ann M|Zhan, Le|Maru, Dipen|Shureiqi, Imad|Pickering, Curtis R|Kiriakova, Galina|Izzo, Julie|He, Nan|Wei, Caimiao|Baladandayuthapani, Veerabhadran|Liang, Han|Kopetz, Scott|Powis, Garth|Guo, Grace L | ||||||||||
| PMID: | 24177031 | ||||||||||
| 23. | |||||||||||
| Journal: | J Biol Chem. 2014 Oct 10;289(41):28421-32. | ||||||||||
| Title: | Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2). | ||||||||||
| Author: | Modica, Salvatore|Cariello, Marica|Morgano, Annalisa|Gross, Isabelle|Vegliante, Maria Carmela|Murzilli, Stefania|Salvatore, Lorena|Freund, Jean-Noel|Sabba, Carlo|Moschetta, Antonio | ||||||||||
| PMID: | 25138215 | ||||||||||
| 24. | |||||||||||
| Journal: | Acta Pharm Sin B. 2015 Mar;5(2):135-44. | ||||||||||
| Title: | Bile acid nuclear receptor FXR and digestive system diseases. | ||||||||||
| Author: | Ding, Lili|Yang, Li|Wang, Zhengtao|Huang, Wendong | ||||||||||
| PMID: | 26579439 | ||||||||||
| 25. | |||||||||||
| Journal: | J Biol Chem. 2015 Mar 6;290(10):6507-15. | ||||||||||
| Title: | MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor. | ||||||||||
| Author: | Yang, Fan|Hu, Ying|Liu, Hui-Xin|Wan, Yu-Jui Yvonne | ||||||||||
| PMID: | 25596928 | ||||||||||
| 26. | |||||||||||
| Journal: | Biochim Biophys Acta. 2015 Jan;1851(1):30-9. | ||||||||||
| Title: | Tissue-specific actions of FXR in metabolism and cancer. | ||||||||||
| Author: | Gadaleta, Raffaella Maria|Cariello, Marica|Sabba, Carlo|Moschetta, Antonio | ||||||||||
| PMID: | 25139561 | ||||||||||
| 27. | |||||||||||
| Journal: | J Nutr. 2016 Feb;146(2):236-42. | ||||||||||
| Title: | Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells. | ||||||||||
| Author: | Selmin, Ornella I|Fang, Changming|Lyon, Adam M|Doetschman, Tom C|Thompson, Patricia A|Martinez, Jesse D|Smith, Jeffrey W|Lance, Peter M|Romagnolo, Donato F | ||||||||||
| PMID: | 26609171 | ||||||||||
| 28. | |||||||||||
| Journal: | Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1044-51. | ||||||||||
| Title: | microRNA-192 suppresses the expression of the farnesoid X receptor. | ||||||||||
| Author: | Krattinger, Regina|Bostrom, Adrian|Schioth, Helgi B|Thasler, Wolfgang E|Mwinyi, Jessica|Kullak-Ublick, Gerd A | ||||||||||
| PMID: | 27079614 | ||||||||||
| 29. | |||||||||||
| Journal: | Acta Chir Belg. 2016 Aug 10:1-8. | ||||||||||
| Title: | The expanding role of the bile acid receptor farnesoid X in the intestine and its potential clinical implications. | ||||||||||
| Author: | Ceulemans, Laurens J|Canovai, Emilio|Verbeke, Len|Pirenne, Jacques|Farre, Ricard | ||||||||||
| PMID: | 27684270 | ||||||||||
| 30. | |||||||||||
| Journal: | Mol Aspects Med. 2017 Aug;56:66-74. | ||||||||||
| Title: | Bile acids and colon cancer: Is FXR the solution of the conundrum? | ||||||||||
| Author: | Gadaleta, Raffaella Maria|Garcia-Irigoyen, Oihane|Moschetta, Antonio | ||||||||||
| PMID: | 28400119 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Res. 2017 Jun 15;77(12):3352-3363. | ||||||||||
| Title: | Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon. | ||||||||||
| Author: | Dermadi, Denis|Valo, Satu|Ollila, Saara|Soliymani, Rabah|Sipari, Nina|Pussila, Marjaana|Sarantaus, Laura|Linden, Jere|Baumann, Marc|Nystrom, Minna | ||||||||||
| PMID: | 28416481 | ||||||||||
| 32. | |||||||||||
| Journal: | Oncotarget. 2017 Jun 28;8(38):63665-63679. | ||||||||||
| Title: | Repression of intestinal transporters and FXR-FGF15 signaling explains bile acids dysregulation in experimental colitis-associated colon cancer. | ||||||||||
| Author: | Cao, Lijuan|Che, Yuan|Meng, Tuo|Deng, Shanshan|Zhang, Jun|Zhao, Min|Xu, Wanfeng|Wang, Dandan|Pu, Zhichen|Wang, Guangji|Hao, Haiping | ||||||||||
| PMID: | 28969019 | ||||||||||
| 33. | |||||||||||
| Journal: | Nat Rev Gastroenterol Hepatol. 2018 Feb;15(2):111-128. | ||||||||||
| Title: | Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. | ||||||||||
| Author: | Jia, Wei|Xie, Guoxiang|Jia, Weiping | ||||||||||
| PMID: | 29018272 | ||||||||||
| 34. | |||||||||||
| Journal: | Physiol Biochem Zool. 2018 Mar/Apr;91(2):797-813. | ||||||||||
| Title: | On the Evolution of Bile Salts and the Farnesoid X Receptor in Vertebrates. | ||||||||||
| Author: | Frisch, Kim|Alstrup, Aage Kristian Olsen | ||||||||||
| PMID: | 29315013 | ||||||||||
| 35. | |||||||||||
| Journal: | PLoS One. 2018 Apr 9;13(4):e0195354. | ||||||||||
| Title: | Colorectal cancer patients with different C-reactive protein levels and 5-year survival times can be differentiated with quantitative serum proteomics. | ||||||||||
| Author: | Holm, Matilda|Saraswat, Mayank|Joenvaara, Sakari|Ristimaki, Ari|Haglund, Caj|Renkonen, Risto | ||||||||||
| PMID: | 29630649 | ||||||||||
| 36. | |||||||||||
| Journal: | Oncol Rep. 2018 Oct;40(4):2067-2078. | ||||||||||
| Title: | Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR135A1/CCNG2 signaling pathway. | ||||||||||
| Author: | Qiao, Pengfei|Li, Shenglong|Zhang, Haogang|Yao, Lei|Wang, Fujing | ||||||||||
| PMID: | 30106441 | ||||||||||