Primary Site >> Colorectal Cancer
Gene >> NR1H4
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Ref: Evaluation of RNA messengers involved in lipid trafficking of human intestinal cells by reverse-transcription polymerase chain reaction with competimer technology and microchip electrophoresis. PMID: 14613201 |
Ref: The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. PMID: 15309887 |
Ref: Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential. PMID: 18537536 Ref: beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. PMID: 18772362 Ref: Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. PMID: 19047134 |
Ref: Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? PMID: 18751930 Ref: Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. PMID: 18981289 |
Ref: Sodium taurocholate inhibits intestinal adenoma formation in APCMin/+ mice, potentially through activation of the farnesoid X receptor. PMID: 20194350 Ref: Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. PMID: 20399894 |
Ref: Tissue-specific function of farnesoid X receptor in liver and intestine. PMID: 21211565 Ref: Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappaB signaling in the intestine. PMID: 21540105 Ref: Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. PMID: 21829567 |
Ref: Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis. PMID: 21780109 Ref: Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19. PMID: 22561792 Ref: Farnesoid X Receptor (FXR) from normal to malignant state. PMID: 22648540 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: Up-regulation of FXR isoforms is not required for stimulation of the expression of genes involved in the lack of response of colon cancer to chemotherapy. PMID: 22898327 Ref: FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PMID: 23056173 Ref: Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis. PMID: 23119029 |
Ref: Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia. PMID: 23348121 Ref: Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients. PMID: 24169962 |
Ref: FXR silencing in human colon cancer by DNA methylation and KRAS signaling. PMID: 24177031 Ref: Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2). PMID: 25138215 |
Ref: Tissue-specific actions of FXR in metabolism and cancer. PMID: 25139561 Ref: MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor. PMID: 25596928 Ref: Bile acid nuclear receptor FXR and digestive system diseases. PMID: 26579439 |
Ref: Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells. PMID: 26609171 Ref: microRNA-192 suppresses the expression of the farnesoid X receptor. PMID: 27079614 Ref: The expanding role of the bile acid receptor farnesoid X in the intestine and its potential clinical implications. PMID: 27684270 |
Ref: Bile acids and colon cancer: Is FXR the solution of the conundrum? PMID: 28400119 Ref: Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon. PMID: 28416481 Ref: Repression of intestinal transporters and FXR-FGF15 signaling explains bile acids dysregulation in experimental colitis-associated colon cancer. PMID: 28969019 |
Ref: Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. PMID: 29018272 Ref: On the Evolution of Bile Salts and the Farnesoid X Receptor in Vertebrates. PMID: 29315013 Ref: Colorectal cancer patients with different C-reactive protein levels and 5-year survival times can be differentiated with quantitative serum proteomics. PMID: 29630649 Ref: Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR135A1/CCNG2 signaling pathway. PMID: 30106441 |