Primary Site >> Colorectal Cancer

Gene >> NQO1

1.
Journal: J Natl Cancer Inst. 1976 Aug;57(2):371-5.
Title: The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer.
Author: Goldin, B R|Gorbach, S L
PMID: 1003518
2.
Journal: Cancer Res. 1990 Dec 1;50(23):7483-9.
Title: Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Author: Siegel, D|Gibson, N W|Preusch, P C|Ross, D
PMID: 1701346
3.
Journal: Free Radic Res Commun. 1990;8(4-6):373-81.
Title: Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.
Author: Ross, D|Siegel, D|Gibson, N W|Pacheco, D|Thomas, D J|Reasor, M|Wierda, D
PMID: 2113030
4.
Journal: Cancer Res. 1990 Nov 15;50(22):7293-300.
Title: Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Author: Siegel, D|Gibson, N W|Preusch, P C|Ross, D
PMID: 2121335
5.
Journal: Int J Cancer. 1990 Mar 15;45(3):403-9.
Title: Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol.
Author: Schlager, J J|Powis, G
PMID: 2307529
6.
Journal: Cancer Commun. 1991 Jul;3(7):199-206.
Title: The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
Author: Walton, M I|Smith, P J|Workman, P
PMID: 1714284
7.
Journal: Carcinogenesis. 1991 May;12(5):905-9.
Title: Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.
Author: de Waziers, I|Cugnenc, P H|Berger, A|Leroux, J P|Beaune, P H
PMID: 2029756
8.
Journal: Eur J Cancer. 1992;28A(10):1597-600.
Title: DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
Author: Walton, M I|Bibby, M C|Double, J A|Plumb, J A|Workman, P
PMID: 1389472
9.
Journal: Mol Pharmacol. 1992 Sep;42(3):531-6.
Title: Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.
Author: Gibson, N W|Hartley, J A|Butler, J|Siegel, D|Ross, D
PMID: 1406604
10.
Journal: Cancer Chemother Pharmacol. 1992;31(1):23-31.
Title: The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells.
Author: Pan, S S|Akman, S A|Forrest, G L|Hipsher, C|Johnson, R
PMID: 1458556
11.
Journal: Cancer Res. 1992 Sep 1;52(17):4608-12.
Title: Effect of treatment duration and glutathione depletion on mitomycin C cytotoxicity in vitro.
Author: Perry, R R|Greaves, B R|Rasberry, U|Barranco, S C
PMID: 1511428
12.
Journal: Int J Radiat Oncol Biol Phys. 1992;22(4):649-53.
Title: Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
Author: Bailey, S M|Suggett, N|Walton, M I|Workman, P
PMID: 1544832
13.
Journal: Cancer Res. 1992 Feb 15;52(4):797-802.
Title: NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
Author: Traver, R D|Horikoshi, T|Danenberg, K D|Stadlbauer, T H|Danenberg, P V|Ross, D|Gibson, N W
PMID: 1737339
14.
Journal: Cancer Chemother Pharmacol. 1993;33(3):215-20.
Title: Isolation and characterization of a mitomycin C-resistant variant of human colon carcinoma HT-29 cells.
Author: Lee, J H|Naito, M|Nakajima, M|Tsuruo, T
PMID: 7505723
15.
Journal: Biochem Pharmacol. 1993 Dec 3;46(11):1999-2005.
Title: Biochemical characterization of a mitomycin C resistant colon cancer cell line variant.
Author: Perry, R R|Kang, Y|Greaves, B
PMID: 7903534
16.
Journal: Oncol Res. 1994;6(10-11):493-500.
Title: Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Author: Ross, D|Beall, H|Traver, R D|Siegel, D|Phillips, R M|Gibson, N W
PMID: 7620217
17.
Journal: Biochem Pharmacol. 1994 Jun 1;47(11):2011-5.
Title: Inhibition of NAD(P)H:quinone oxidoreductase1 in ethacrynic acid-resistant human colon carcinoma cells.
Author: Joseph, P|Sharma, M C|Jaiswal, A K
PMID: 8010986
18.
Journal: Mol Cell Biol. 1994 Sep;14(9):5997-6003.
Title: Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.
Author: Yao, K S|Xanthoudakis, S|Curran, T|O'Dwyer, P J
PMID: 8065332
19.
Journal: Cancer Res. 1994 Apr 1;54(7):1622-6.
Title: Mapping of DNA alkylation sites induced by aziridinylbenzoquinones in human cells by ligation-mediated polymerase chain reaction.
Author: Lee, C S|Pfeifer, G P|Gibson, N W
PMID: 8137269
20.
Journal: Cancer Res. 1994 May 1;54(9):2398-403.
Title: Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Author: Lee, J H|Naito, M|Tsuruo, T
PMID: 8162587
21.
Journal: Cancer Res. 1994 Jun 15;54(12):3082-7.
Title: Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells.
Author: O'Dwyer, P J|Yao, K S|Ford, P|Godwin, A K|Clayton, M
PMID: 8205521
22.
Journal: Int J Cancer. 1994 Jan 2;56(1):134-9.
Title: Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.
Author: Plumb, J A|Workman, P
PMID: 8262670
23.
Journal: J Natl Cancer Inst. 1995 Dec 6;87(23):1802-3.
Title: Re: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer.
Author: Rosvold, E A|McGlynn, K A|Lustbader, E D|Buetow, K H
PMID: 7473840
24.
Journal: Br J Cancer. 1995 Oct;72(4):917-21.
Title: DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
Author: Smitskamp-Wilms, E|Giaccone, G|Pinedo, H M|van der Laan, B F|Peters, G J
PMID: 7547240
25.
Journal: J Natl Cancer Inst. 1995 Jul 5;87(13):1022-4.
Title: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer.
Author: Kolesar, J M|Kuhn, J G|Burris, H A 3rd
PMID: 7629875
26.
Journal: Cancer Res. 1995 Jan 15;55(2):330-5.
Title: NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells.
Author: Pan, S S|Forrest, G L|Akman, S A|Hu, L T
PMID: 7812966
27.
Journal: Biochem Pharmacol. 1996 Mar 8;51(5):645-52.
Title: Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin.
Author: Beall, H D|Liu, Y|Siegel, D|Bolton, E M|Gibson, N W|Ross, D
PMID: 8615901
28.
Journal: Cancer Res. 1996 Apr 15;56(8):1731-6.
Title: Alternative splicing and differential expression of DT-diaphorase transcripts in human colon tumors and in peripheral mononuclear cells in response to mitomycin C treatment.
Author: Yao, K S|Godwin, A K|Johnson, C|O'Dwyer, P J
PMID: 8620484
29.
Journal: Chem Biol Interact. 1996 May 6;100(3):267-76.
Title: Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation.
Author: Sun, X|Ross, D
PMID: 8653808
30.
Journal: J Clin Invest. 1996 Sep 1;98(5):1210-7.
Title: Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz.
Author: O'Dwyer, P J|Szarka, C E|Yao, K S|Halbherr, T C|Pfeiffer, G R|Green, F|Gallo, J M|Brennan, J|Frucht, H|Goosenberg, E B|Hamilton, T C|Litwin, S|Balshem, A M|Engstrom, P F|Clapper, M L
PMID: 8787684
31.
Journal: Anticancer Drug Des. 1996 Sep;11(6):421-38.
Title: Synthesis and anti-cancer activity of 2,6-disubstituted N-methylpiperidine derivatives and their N-oxides.
Author: Henderson, N D|Plumb, J A|Robins, D J|Workman, P
PMID: 8836108
32.
Journal: Nutr Cancer. 1996;26(1):21-9.
Title: Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans.
Author: Bouhnik, Y|Flourie, B|Riottot, M|Bisetti, N|Gailing, M F|Guibert, A|Bornet, F|Rambaud, J C
PMID: 8844718
33.
Journal: Cancer Res. 1996 Nov 15;56(22):5253-9.
Title: The NAD(P)H:quinone oxidoreductase locus in human colon carcinoma HCT 116 cells resistant to mitomycin C.
Author: Hu, L T|Stamberg, J|Pan, S
PMID: 8912865
34.
Journal: Br J Cancer. 1997;75(1):69-75.
Title: Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).
Author: Traver, R D|Siegel, D|Beall, H D|Phillips, R M|Gibson, N W|Franklin, W A|Ross, D
PMID: 9000600
35.
Journal: Carcinogenesis. 1997 Jan;18(1):43-6.
Title: Quinone-induced DNA single strand breaks in a human colon carcinoma cell line.
Author: D'Odorico, A|Sturniolo, G C|Bilton, R F|Morris, A I|Gilmore, I T|Naccarato, R
PMID: 9054588
36.
Journal: Oncol Res. 1997;9(6-7):295-302.
Title: Importance of glutathione and associated enzymes in drug response.
Author: Shen, H|Kauvar, L|Tew, K D
PMID: 9406235
37.
Journal: Br J Cancer. 1997;76(12):1596-603.
Title: Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.
Author: Bailey, S M|Wyatt, M D|Friedlos, F|Hartley, J A|Knox, R J|Lewis, A D|Workman, P
PMID: 9413948
38.
Journal: Biochem Pharmacol. 1998 Feb 1;55(3):253-60.
Title: Pharmacological and biochemical determinants of the antitumour activity of the indoloquinone EO9.
Author: Cummings, J|Spanswick, V J|Gardiner, J|Ritchie, A|Smyth, J F
PMID: 9484790
39.
Journal: Cancer Chemother Pharmacol. 1998;41(5):417-22.
Title: Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase.
Author: Brunton, V G|Steele, G|Lewis, A D|Workman, P
PMID: 9523739
40.
Journal: Chem Biol Interact. 1998 Apr 24;111-112:199-211.
Title: Coordinate changes in expression of protective genes in drug-resistant cells.
Author: Tew, K D|O'Brien, M|Laing, N M|Shen, H
PMID: 9679555
41.
Journal: Jpn J Cancer Res. 1998 Sep;89(9):910-5.
Title: Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Author: Mikami, K|Naito, M|Ishiguro, T|Yano, H|Tomida, A|Yamada, T|Tanaka, N|Shirakusa, T|Tsuruo, T
PMID: 9818026
42.
Journal: Clin Cancer Res. 1998 Dec;4(12):3083-8.
Title: A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Author: Winski, S L|Hargreaves, R H|Butler, J|Ross, D
PMID: 9865924
43.
Journal: J Surg Res. 1998 Dec;80(2):177-81.
Title: The importance of DT-diaphorase in mitomycin C resistance in human colon cancer cell lines.
Author: Lambert, P A|Kang, Y|Greaves, B|Perry, R R
PMID: 9878310
44.
Journal: Biochem Pharmacol. 1999 Jan 1;57(1):27-37.
Title: Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines.
Author: Karczewski, J M|Peters, J G|Noordhoek, J
PMID: 9920282
45.
Journal: Jpn J Cancer Res. 1999 May;90(5):571-7.
Title: Regulatory network of mitomycin C action in human colon cancer cells.
Author: Suzuki, K|Yamamoto, W|Park, J S|Hanaoka, H|Okamoto, R|Kirihara, Y|Yorishima, T|Okamura, T|Kumazaki, T|Nishiyama, M
PMID: 10391098
46.
Journal: J Natl Cancer Inst. 1999 Nov 17;91(22):1940-9.
Title: DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.
Author: Kelland, L R|Sharp, S Y|Rogers, P M|Myers, T G|Workman, P
PMID: 10564678
47.
Journal: Arch Toxicol. 2000 Jan;73(10-11):528-31.
Title: NAD(P)H quinone oxidoreductase 1 codon 609 polymorphism and its association to colorectal cancer.
Author: Harth, V|Donat, S|Ko, Y|Abel, J|Vetter, H|Bruning, T
PMID: 10663383
48.
Journal: J Med Chem. 2000 Aug 10;43(16):3157-67.
Title: Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase.
Author: Flader, C|Liu, J|Borch, R F
PMID: 10956224
49.
Journal: Carcinogenesis. 2000 Oct;21(10):1813-9.
Title: NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.
Author: Lafuente, M J|Casterad, X|Trias, M|Ascaso, C|Molina, R|Ballesta, A|Zheng, S|Wiencke, J K|Lafuente, A
PMID: 11023538
50.
Journal: Crit Rev Oncol Hematol. 2000 Nov-Dec;36(2-3):141-57.
Title: The multilayered postconfluent cell culture as a model for drug screening.
Author: Padron, J M|van der Wilt, C L|Smid, K|Smitskamp-Wilms, E|Backus, H H|Pizao, P E|Giaccone, G|Peters, G J
PMID: 11033303
51.
Journal: Mol Pharmacol. 2000 Nov;58(5):1146-55.
Title: Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.
Author: Sharp, S Y|Kelland, L R|Valenti, M R|Brunton, L A|Hobbs, S|Workman, P
PMID: 11040064
52.
Journal: Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1188-93. Epub 2001 Jan 23.
Title: Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1.
Author: Asher, G|Lotem, J|Cohen, B|Sachs, L|Shaul, Y
PMID: 11158615
53.
Journal: Cancer Detect Prev. 2001;25(4):352-61.
Title: Chronic dosing of oltipraz in people at increased risk for colorectal cancer.
Author: Szarka, C E|Yao, K S|Pfeiffer, G R|Balshem, A M|Litwin, S|Frucht, H|Goosenberg, E B|Engstrom, P F|Clapper, M L|O'Dwyer, P J
PMID: 11531012
54.
Journal: J Med Chem. 2001 Sep 27;44(20):3311-9.
Title: Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.
Author: Swann, E|Barraja, P|Oberlander, A M|Gardipee, W T|Hudnott, A R|Beall, H D|Moody, C J
PMID: 11563930
55.
Journal: Cancer Gene Ther. 2002 Feb;9(2):209-17.
Title: Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
Author: Misra, Veet|Klamut, Henry J|Rauth, A M
PMID: 11857040
56.
Journal: Cancer Res. 2002 Mar 1;62(5):1420-4.
Title: Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells.
Author: Winski, Shannon L|Koutalos, Yiannis|Bentley, David L|Ross, David
PMID: 11888914
57.
Journal: Int J Oncol. 2002 Apr;20(4):835-8.
Title: Lack of NQO1 induction in human tumor cells is not due to changes in the promoter region of the gene.
Author: Begleiter, Asher|Lange, Laurie
PMID: 11894133
58.
Journal: Int J Clin Oncol. 2002 Apr;7(2):103-8.
Title: NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
Author: Hamajima, Nobuyuki|Matsuo, Keitaro|Iwata, Hiroji|Shinoda, Masayuki|Yamamura, Yoshitaka|Kato, Tomoyuki|Hatooka, Shunzo|Mitsudomi, Tetsuya|Suyama, Motokazu|Kagami, Yoshitoyo|Ogura, Michinori|Ando, Manabu|Sugimura, Yoshiki|Tajima, Kazuo
PMID: 12018106
59.
Journal: J Med Chem. 2002 Aug 1;45(16):3540-8.
Title: Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase.
Author: Hernick, Marcy|Flader, Carolee|Borch, Richard F
PMID: 12139465
60.
Journal: Carcinogenesis. 2002 Nov;23(11):1839-49.
Title: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Author: Sachse, Christoph|Smith, Gillian|Wilkie, Murray J V|Barrett, Jennifer H|Waxman, Robin|Sullivan, Frank|Forman, David|Bishop, D Timothy|Wolf, C Roland
PMID: 12419832
61.
Journal: IARC Sci Publ. 2002;156:495-7.
Title: NQO1 and mEH exon 4 (mEH4) gene polymorphisms, smoking and colorectal cancer risk.
Author: Mitrou, P|Watson, M|Bingham, S|Stebbings, W S|Speakman, C T|Loktionov, A
PMID: 12484241
62.
Journal: Anticancer Res. 2002 Sep-Oct;22(5):2749-52.
Title: Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer.
Author: Takagi, Sho|Kinouchi, Yoshitaka|Hiwatashi, Nobuo|Hirai, Masashi|Suzuki, Susumu|Takahashi, Seiichi|Negoro, Kenichi|Obana, Nobuya|Shimosegawa, Tooru
PMID: 12529991
63.
Journal: J Biol Chem. 2003 Mar 21;278(12):10368-73. Epub 2003 Jan 14.
Title: Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems.
Author: Anwar, Adil|Dehn, Donna|Siegel, David|Kepa, Jadwiga K|Tang, Luo Jia|Pietenpol, Jennifer A|Ross, David
PMID: 12529318
64.
Journal: Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):566-72.
Title: Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
Author: Begleiter, Asher|Sivananthan, Kosala|Curphey, Thomas J|Bird, Ranjana P
PMID: 12815004
65.
Journal: Anticancer Drugs. 2003 Sep;14(8):601-15.
Title: Synthesis and biological evaluation of novel diaziridinylquinone-acridine conjugates.
Author: Di Francesco, Angela M|Mayalarp, Stephen P|Kim, Susan|Butler, John|Lee, Moses
PMID: 14501382
66.
Journal: Cancer Lett. 2004 Feb 10;204(1):15-21.
Title: Changes in cecal microbial metabolism of rats induced by individual and a mixture of drinking water disinfection by-products.
Author: George, S E|Wolf, D C|Brooks, L R|Bailey, K C|Hooth, M J|Nelson, G M
PMID: 14744530
67.
Journal: Bioorg Med Chem. 2004 Apr 1;12(7):1667-87.
Title: Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).
Author: Fryatt, Tara|Pettersson, Hanna I|Gardipee, Walter T|Bray, Kurtis C|Green, Stephen J|Slawin, Alexandra M Z|Beall, Howard D|Moody, Christopher J
PMID: 15028260
68.
Journal: J Biol Chem. 2004 Jun 18;279(25):26019-27. Epub 2004 Mar 26.
Title: NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.
Author: Nho, Chu Won|O'Dwyer, Peter J
PMID: 15047705
69.
Journal: Cancer Treat Rev. 2004 Aug;30(5):437-49.
Title: DT-diaphorase: a target for new anticancer drugs.
Author: Danson, S|Ward, T H|Butler, J|Ranson, M
PMID: 15245776
70.
Journal: Int J Cancer. 2004 Nov 1;112(2):259-64.
Title: Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer.
Author: Turner, Faye|Smith, Gillian|Sachse, Christoph|Lightfoot, Tracy|Garner, R Colin|Wolf, C Roland|Forman, David|Bishop, D Timothy|Barrett, Jennifer H
PMID: 15352038
71.
Journal: Cancer Chemother Pharmacol. 2005 Sep;56(3):307-16. Epub 2005 May 5.
Title: Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo.
Author: Digby, Tyler|Leith, Marsha K|Thliveris, James A|Begleiter, Asher
PMID: 15877230
72.
Journal: Pharmacogenet Genomics. 2005 Aug;15(8):535-46.
Title: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
Author: Landi, Stefano|Gemignani, Federica|Moreno, Victor|Gioia-Patricola, Lydie|Chabrier, Amelie|Guino, Elisabeth|Navarro, Matilde|de Oca, Javier|Capella, Gabriel|Canzian, Federico
PMID: 16006997
73.
Journal: Mutat Res. 2006 Jan 29;593(1-2):39-49. Epub 2005 Jul 21.
Title: Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.
Author: van der Logt, Elise M J|Bergevoet, Saskia M|Roelofs, Hennie M J|Te Morsche, Rene H M|Dijk, Yvo van|Wobbes, Theo|Nagengast, Fokko M|Peters, Wilbert H M
PMID: 16039674
74.
Journal: Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):979-87.
Title: NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
Author: Chao, Chun|Zhang, Zuo-Feng|Berthiller, Julien|Boffetta, Paolo|Hashibe, Mia
PMID: 16702380
75.
Journal: Free Radic Res. 2006 Sep;40(9):974-8.
Title: The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells.
Author: Hasinoff, Brian B|Begleiter, Asher
PMID: 17015278
76.
Journal: Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2422-6.
Title: A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer.
Author: Begleiter, Asher|Hewitt, Donna|Maksymiuk, Andrew W|Ross, David A|Bird, Ranjana P
PMID: 17164365
77.
Journal: Mol Cancer Ther. 2007 Apr;6(4):1198-211.
Title: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Author: Sharp, Swee Y|Prodromou, Chrisostomos|Boxall, Kathy|Powers, Marissa V|Holmes, Joanna L|Box, Gary|Matthews, Thomas P|Cheung, Kwai-Ming J|Kalusa, Andrew|James, Karen|Hayes, Angela|Hardcastle, Anthea|Dymock, Brian|Brough, Paul A|Barril, Xavier|Cansfield, Jul
PMID: 17431102
78.
Journal: Nutr Cancer. 2008;60(2):204-15.
Title: The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population.
Author: Tijhuis, Mariken J|Boerboom, Anne-Marie J F|Visker, Marleen H P W|Op den Camp, Liesbeth|Nagengast, Fokko M|Tan, Adriaan C I T L|Rietjens, Ivonne M C M|Kok, Frans J|Aarts, Jac M M J G|Kampman, Ellen
PMID: 18444152
79.
Journal: Mol Carcinog. 2009 Mar;48(3):202-11.
Title: Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil.
Author: Liu, Guangming|Hu, Xin|Varani, James|Chakrabarty, Subhas
PMID: 18618519
80.
Journal: Oncol Rep. 2009 Jun;21(6):1559-65.
Title: Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
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Title: The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol.
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Title: Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imbalance.
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Title: Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway.
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Title: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.
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Title: Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells.
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Title: Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway.
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Title: UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of beta-lapachone in human colon cancer cells.
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Title: Different treatment strategies and molecular features between right-sided and left-sided colon cancers.
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Title: Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.
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Title: Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases.
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Title: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer.
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Title: Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.
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Title: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer.
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Journal: Eur J Med Chem. 2016 Oct 21;122:1-16.
Title: Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
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Title: Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells.
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Journal: Inflamm Bowel Dis. 2016 Nov;22(11):2593-2606.
Title: Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes.
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Title: NQO1 inhibits proteasome-mediated degradation of HIF-1alpha.
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Journal: J Nutr Biochem. 2017 Apr;42:17-25.
Title: Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression.
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Title: Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).
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Journal: Eur J Med Chem. 2017 May 26;132:310-321.
Title: Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation.
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Title: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway.
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Title: NQO1 Gene C609T Polymorphism (dbSNP: rs1800566) and Digestive Tract Cancer Risk: A Meta-Analysis.
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Title: 17beta-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells.
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