Primary Site >> Colorectal Cancer
Gene >> NQO1
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Ref: The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. PMID: 1003518 |
Ref: Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. PMID: 1701346 Ref: Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma. PMID: 2113030 Ref: Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells. PMID: 2121335 Ref: Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol. PMID: 2307529 |
Ref: The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9. PMID: 1714284 Ref: Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples. PMID: 2029756 |
Ref: DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas. PMID: 1389472 Ref: Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity. PMID: 1406604 Ref: The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells. PMID: 1458556 Ref: Effect of treatment duration and glutathione depletion on mitomycin C cytotoxicity in vitro. PMID: 1511428 Ref: Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones. PMID: 1544832 Ref: NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. PMID: 1737339 |
Ref: Isolation and characterization of a mitomycin C-resistant variant of human colon carcinoma HT-29 cells. PMID: 7505723 Ref: Biochemical characterization of a mitomycin C resistant colon cancer cell line variant. PMID: 7903534 |
Ref: Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies. PMID: 7620217 Ref: Inhibition of NAD(P)H:quinone oxidoreductase1 in ethacrynic acid-resistant human colon carcinoma cells. PMID: 8010986 Ref: Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. PMID: 8065332 Ref: Mapping of DNA alkylation sites induced by aziridinylbenzoquinones in human cells by ligation-mediated polymerase chain reaction. PMID: 8137269 Ref: Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells. PMID: 8162587 Ref: Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells. PMID: 8205521 Ref: Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity. PMID: 8262670 |
Ref: Re: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. PMID: 7473840 Ref: DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents? PMID: 7547240 Ref: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. PMID: 7629875 Ref: NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells. PMID: 7812966 |
Ref: Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin. PMID: 8615901 Ref: Alternative splicing and differential expression of DT-diaphorase transcripts in human colon tumors and in peripheral mononuclear cells in response to mitomycin C treatment. PMID: 8620484 Ref: Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation. PMID: 8653808 Ref: Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. PMID: 8787684 Ref: Synthesis and anti-cancer activity of 2,6-disubstituted N-methylpiperidine derivatives and their N-oxides. PMID: 8836108 Ref: Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans. PMID: 8844718 Ref: The NAD(P)H:quinone oxidoreductase locus in human colon carcinoma HCT 116 cells resistant to mitomycin C. PMID: 8912865 |
Ref: Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase). PMID: 9000600 Ref: Quinone-induced DNA single strand breaks in a human colon carcinoma cell line. PMID: 9054588 Ref: Importance of glutathione and associated enzymes in drug response. PMID: 9406235 Ref: Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9. PMID: 9413948 |
Ref: Pharmacological and biochemical determinants of the antitumour activity of the indoloquinone EO9. PMID: 9484790 Ref: Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase. PMID: 9523739 Ref: Coordinate changes in expression of protective genes in drug-resistant cells. PMID: 9679555 Ref: Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase. PMID: 9818026 Ref: A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. PMID: 9865924 Ref: The importance of DT-diaphorase in mitomycin C resistance in human colon cancer cell lines. PMID: 9878310 |
Ref: Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines. PMID: 9920282 Ref: Regulatory network of mitomycin C action in human colon cancer cells. PMID: 10391098 Ref: DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. PMID: 10564678 |
Ref: NAD(P)H quinone oxidoreductase 1 codon 609 polymorphism and its association to colorectal cancer. PMID: 10663383 Ref: Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase. PMID: 10956224 Ref: NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors. PMID: 11023538 Ref: The multilayered postconfluent cell culture as a model for drug screening. PMID: 11033303 Ref: Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo. PMID: 11040064 |
Ref: Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. PMID: 11158615 Ref: Chronic dosing of oltipraz in people at increased risk for colorectal cancer. PMID: 11531012 Ref: Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2. PMID: 11563930 |
Ref: Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro. PMID: 11857040 Ref: Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells. PMID: 11888914 Ref: Lack of NQO1 induction in human tumor cells is not due to changes in the promoter region of the gene. PMID: 11894133 Ref: NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese. PMID: 12018106 Ref: Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase. PMID: 12139465 Ref: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. PMID: 12419832 Ref: NQO1 and mEH exon 4 (mEH4) gene polymorphisms, smoking and colorectal cancer risk. PMID: 12484241 Ref: Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer. PMID: 12529991 |
Ref: Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. PMID: 12529318 Ref: Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats. PMID: 12815004 Ref: Synthesis and biological evaluation of novel diaziridinylquinone-acridine conjugates. PMID: 14501382 |
Ref: Changes in cecal microbial metabolism of rats induced by individual and a mixture of drinking water disinfection by-products. PMID: 14744530 Ref: Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1). PMID: 15028260 Ref: NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling. PMID: 15047705 Ref: DT-diaphorase: a target for new anticancer drugs. PMID: 15245776 Ref: Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer. PMID: 15352038 |
Ref: Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo. PMID: 15877230 Ref: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. PMID: 16006997 |
Ref: Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. PMID: 16039674 Ref: NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis. PMID: 16702380 Ref: The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells. PMID: 17015278 Ref: A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer. PMID: 17164365 |
Ref: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. PMID: 17431102 |
Ref: The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population. PMID: 18444152 |
Ref: Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil. PMID: 18618519 Ref: Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats. PMID: 19424637 Ref: Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. PMID: 19706542 Ref: Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). PMID: 19877692 |
Ref: The chemopreventive effects of Carpesium abrotanoides are mediated by induction of phase II detoxification enzymes and apoptosis in human colorectal cancer cells. PMID: 20136434 Ref: [Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells]. PMID: 20175231 Ref: Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. PMID: 20534171 Ref: NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and colorectal cancer predisposition in the ethnic Kashmiri population. PMID: 20593958 Ref: Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population. PMID: 20878130 Ref: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. PMID: 20924967 Ref: Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications. PMID: 20941451 |
Ref: Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. PMID: 20967519 Ref: Effect of gallic acid on xenobiotic metabolizing enzymes in 1,2-dimethyl hydrazine induced colon carcinogenesis in Wistar rats--a chemopreventive approach. PMID: 21172399 Ref: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. PMID: 21256954 |
Ref: Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats. PMID: 22115893 Ref: Association of NQO1 Pro187Ser polymorphism with the risks for colorectal cancer and colorectal adenoma: a meta-analysis. PMID: 22116627 Ref: Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis. PMID: 22215148 Ref: Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisp PMID: 22266358 Ref: A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis. PMID: 22272361 Ref: Contribution of NAD(P)H quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and risk of colorectal adenoma and colorectal cancer in Caucasians: a meta-analysis. PMID: 22306249 Ref: NAD(P)H quinone oxidoreductase 1 (NQO1) genetic C609T polymorphism is associated with the risk of digestive tract cancer: a meta-analysis based on 21 case-control studies. PMID: 22387672 Ref: Comparative label-free LC-MS/MS analysis of colorectal adenocarcinoma and metastatic cells treated with 5-fluorouracil. PMID: 22623418 Ref: NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia. PMID: 23358185 Ref: Potential chemoprevention activity of pterostilbene by enhancing the detoxifying enzymes in the HT-29 cell line. PMID: 23464466 |
Ref: The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. PMID: 23135549 Ref: Absolute quantification of NAD(P)H:quinone oxidoreductase 1 in human tumor cell lines and tissues by liquid chromatography-mass spectrometry/mass spectrometry using both isotopic and non-isotopic internal standards. PMID: 23540248 Ref: Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. PMID: 23637463 Ref: NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphism association with digestive tract cancer: a meta-analysis. PMID: 23725139 Ref: Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imbalance. PMID: 23758064 Ref: Association between NQO1 C609T polymorphism and colorectal cancer risk. PMID: 23893397 Ref: UDP-glucuronosyltransferase 1A compromises intracellular accumulation and anti-cancer effect of tanshinone IIA in human colon cancer cells. PMID: 24244442 |
Ref: Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. PMID: 22911891 Ref: Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians. PMID: 24142528 Ref: Modulatory effect of troxerutin on biotransforming enzymes and preneoplasic lesions induced by 1,2-dimethylhydrazine in rat colon carcinogenesis. PMID: 24512697 Ref: Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival. PMID: 24695690 Ref: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. PMID: 24714741 Ref: Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway. PMID: 24761924 Ref: Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer. PMID: 24830960 Ref: NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis. PMID: 25276147 Ref: Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity? PMID: 25389454 |
Ref: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. PMID: 25178491 Ref: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite. PMID: 25179160 Ref: Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. PMID: 25380307 Ref: Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway. PMID: 25545372 Ref: UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of beta-lapachone in human colon cancer cells. PMID: 25692465 Ref: Oxidoreductase-Facilitated Visualization and Detection of Human Cancer Cells. PMID: 26005900 Ref: Different treatment strategies and molecular features between right-sided and left-sided colon cancers. PMID: 26074686 Ref: Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. PMID: 26223300 Ref: Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases. PMID: 26312918 Ref: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. PMID: 26388988 Ref: Deoxynyboquinones as NQO1-Activated Cancer Therapeutics. PMID: 26444384 |
Ref: Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas. PMID: 26451011 Ref: Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. PMID: 26969764 Ref: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. PMID: 27323826 Ref: Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights. PMID: 27341379 Ref: Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells. PMID: 27636860 Ref: Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes. PMID: 27661668 Ref: NQO1 inhibits proteasome-mediated degradation of HIF-1alpha. PMID: 27966538 |
Ref: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. PMID: 27860235 Ref: Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression. PMID: 28107678 Ref: Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). PMID: 28236663 Ref: Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation. PMID: 28395199 Ref: Targeted proteome analysis with isotope-coded protein labels for monitoring the influence of dietary phytochemicals on the expression of cytoprotective proteins in primary human colon cells. PMID: 28688915 Ref: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. PMID: 28737825 Ref: Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells. PMID: 28986187 Ref: [A Case of Ascending Colon Cancer with Synchronous Liver Metastases and Peritoneal Dissemination]. PMID: 29394555 |
Ref: NQO1 Gene C609T Polymorphism (dbSNP: rs1800566) and Digestive Tract Cancer Risk: A Meta-Analysis. PMID: 29652514 Ref: 17beta-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells. PMID: 30336658 |