Primary Site >> Colorectal Cancer

Gene >> NFE2L2

1.
Journal: Biochem Pharmacol. 2003 Jul 1;66(1):51-61.
Title: Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents.
Author: Sherratt, Philip J|McLellan, Lesley I|Hayes, John D
PMID: 12818365
2.
Journal: Zhonghua Yi Xue Za Zhi. 2005 Mar 30;85(12):819-24.
Title: [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells].
Author: Wang, Min|Li, Yan-Qing|Zhong, Ning|Chen, Jian|Xu, Xiao-Qun|Yuan, Meng-Biao
PMID: 15949398
3.
Journal: Cell Cycle. 2005 Sep;4(9):1201-15.
Title: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Author: Aggarwal, Bharat B|Ichikawa, Haruyo
PMID: 16082211
4.
Journal: Mutat Res. 2005 Dec 11;591(1-2):74-92.
Title: Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis.
Author: Pool-Zobel, Beatrice|Veeriah, Selvaraju|Bohmer, Frank-D
PMID: 16083918
5.
Journal: Zhonghua Yi Xue Za Zhi. 2006 Jan 10;86(2):82-7.
Title: [The role of NF-E2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1A and its isoforms by epigallocatechin gallate in colon cancer cells].
Author: Yang, Xiao-yun|Zhao, Wei-ping|Li, Yan-qing|Sun, Zi-yuan|Zhang, Yan|Guo, Yu-ting|Yuan, Jun-hua|Zhu, Qiang|Wang, Min
PMID: 16620709
6.
Journal: Cancer Res. 2006 Dec 15;66(24):11580-4.
Title: Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
Author: Khor, Tin Oo|Huang, Mou-Tuan|Kwon, Ki Han|Chan, Jefferson Y|Reddy, Bandaru S|Kong, Ah-Ng
PMID: 17178849
7.
Journal: Acta Pol Pharm. 2006 Sep-Oct;63(5):369-73.
Title: Cancer chemopreventive agents-drugs for the 21st century?
Author: Baer-Dubowska, Wanda
PMID: 17357586
8.
Journal: Curr Opin Gastroenterol. 2007 Jan;23(1):55-9.
Title: The use of nitric oxide-donating nonsteroidal anti-inflammatory drugs in the chemoprevention of colorectal neoplasia.
Author: Rigas, Basil
PMID: 17133086
9.
Journal: Int J Oncol. 2007 May;30(5):1099-107.
Title: Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients.
Author: Vendrell, Elisenda|Ribas, Maria|Valls, Joan|Sole, Xavier|Grau, Monica|Moreno, Victor|Capella, Gabriel|Peinado, Miguel A
PMID: 17390011
10.
Journal: Pharmacology. 2007;80(4):269-78. Epub 2007 Jul 26.
Title: Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice.
Author: Yuan, Jun-Hua|Li, Yan-Qing|Yang, Xiao-Yun
PMID: 17657175
11.
Journal: Biochem Soc Trans. 2007 Nov;35(Pt 5):1364-8.
Title: Novel agents for cancer prevention based on nitric oxide.
Author: Rigas, B
PMID: 17956352
12.
Journal: Cell Mol Life Sci. 2008 Jun;65(11):1631-52.
Title: Curcumin: from ancient medicine to current clinical trials.
Author: Hatcher, H|Planalp, R|Cho, J|Torti, F M|Torti, S V
PMID: 18324353
13.
Journal: Nutr Cancer. 2008;60(2):204-15.
Title: The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population.
Author: Tijhuis, Mariken J|Boerboom, Anne-Marie J F|Visker, Marleen H P W|Op den Camp, Liesbeth|Nagengast, Fokko M|Tan, Adriaan C I T L|Rietjens, Ivonne M C M|Kok, Frans J|Aarts, Jac M M J G|Kampman, Ellen
PMID: 18444152
14.
Journal: Antioxid Redox Signal. 2008 Sep;10(9):1491-500.
Title: GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.
Author: Banning, Antje|Florian, Simone|Deubel, Stefanie|Thalmann, Sophie|Muller-Schmehl, Katrin|Jacobasch, Gisela|Brigelius-Flohe, Regina
PMID: 18479189
15.
Journal: Biochem Pharmacol. 2008 Dec 1;76(11):1485-9.
Title: Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis.
Author: Li, Wenge|Khor, Tin Oo|Xu, Changjiang|Shen, Guoxiang|Jeong, Woo-Sik|Yu, Siwang|Kong, Ah-Ng
PMID: 18694732
16.
Journal: Planta Med. 2008 Oct;74(13):1540-7.
Title: Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway.
Author: Khor, Tin Oo|Yu, Siwang|Kong, Ah-Ng
PMID: 18937168
17.
Journal: Cancer Prev Res (Phila). 2008 Aug;1(3):187-91.
Title: Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.
Author: Khor, Tin Oo|Huang, Mou-Tuan|Prawan, Auemduan|Liu, Yue|Hao, Xingpei|Yu, Siwang|Cheung, William Ka Lung|Chan, Jefferson Y|Reddy, Bandaru S|Yang, Chung S|Kong, Ah-Ng
PMID: 19138955
18.
Journal: Eur J Cancer. 2009 Aug;45(12):2219-27.
Title: Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells.
Author: Akhdar, Hanane|Loyer, Pascal|Rauch, Claudine|Corlu, Anne|Guillouzo, Andre|Morel, Fabrice
PMID: 19524433
19.
Journal: Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14547-51.
Title: Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells.
Author: Li, Chun-Qi|Kim, Min Young|Godoy, Luiz C|Thiantanawat, Apinya|Trudel, Laura J|Wogan, Gerald N
PMID: 19706542
20.
Journal: Chin Med J (Engl). 2009 Jul 20;122(14):1660-5.
Title: Modulation of NRF2 and UGT1A expression by epigallocatechin-3-gallate in colon cancer cells and BALB/c mice.
Author: Zhang, Zhi-mian|Yang, Xiao-yun|Yuan, Jun-hua|Sun, Zi-yuan|Li, Yan-qing
PMID: 19719968
21.
Journal: Oncogene. 2009 Nov 12;28(45):3983-96.
Title: Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).
Author: Arlt, A|Bauer, I|Schafmayer, C|Tepel, J|Muerkoster, S Sebens|Brosch, M|Roder, C|Kalthoff, H|Hampe, J|Moyer, M P|Folsch, U R|Schafer, H
PMID: 19734940
22.
Journal: Biochimie. 2010 Jan;92(1):110-5.
Title: Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells.
Author: Park, Eun Jung|Lim, Jun Hee|Nam, Sung Il|Park, Jong Wook|Kwon, Taeg Kyu
PMID: 19833168
23.
Journal: Carcinogenesis. 2010 May;31(5):880-5.
Title: Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.
Author: Cheung, Ka Lung|Khor, Tin Oo|Huang, Mou-Tuan|Kong, Ah-Ng
PMID: 19959557
24.
Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Jan;39(1):17-23.
Title: [Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells].
Author: Wu, Xiao-yuan|Qu, Li-yan|Quan, Kang|Jiang, Yan-ling|Tang, Xiu-wen
PMID: 20175231
25.
Journal: Molecules. 2010 May 7;15(5):3338-55.
Title: The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
Author: Wondrak, Georg Thomas|Villeneuve, Nicole F|Lamore, Sarah D|Bause, Alexandra S|Jiang, Tao|Zhang, Donna D
PMID: 20657484
26.
Journal: Oxid Med Cell Longev. 2010 Jan-Feb;3(1):23-34.
Title: Redox regulation in cancer: a double-edged sword with therapeutic potential.
Author: Acharya, Asha|Das, Ila|Chandhok, Des|Saha, Tapas
PMID: 20716925
27.
Journal: Nutr Cancer. 2010;62(7):919-30.
Title: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Author: Goel, Ajay|Aggarwal, Bharat B
PMID: 20924967
28.
Journal: Nutr Cancer. 2010;62(7):947-57.
Title: Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2.
Author: Bat-Chen, Wolf|Golan, Tal|Peri, Irena|Ludmer, Zvi|Schwartz, Betty
PMID: 20924970
29.
Journal: Biol Pharm Bull. 2010;33(10):1650-7.
Title: Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways.
Author: Yun, Ji Ho|Lee, Saet Byoul|Lee, Hee Ju|Kim, Chul Young|Kim, Mi Ae|Sohn, Young Chang|Nho, Chu Won
PMID: 20930371
30.
Journal: J Nutr Biochem. 2011 May;22(5):426-40.
Title: Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression.
Author: Boettler, Ute|Sommerfeld, Katharina|Volz, Nadine|Pahlke, Gudrun|Teller, Nicole|Somoza, Veronika|Lang, Roman|Hofmann, Thomas|Marko, Doris
PMID: 20655719
31.
Journal: AAPS J. 2011 Mar;13(1):1-13.
Title: Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis.
Author: Wu, Tien-Yuan|Khor, Tin Oo|Saw, Constance Lay Lay|Loh, Stephanie C|Chen, Alvin I|Lim, Soon Sung|Park, Jung Han Yoon|Cai, Li|Kong, Ah-Ng Tony
PMID: 20967519
32.
Journal: Chem Biol Interact. 2011 May 30;191(1-3):239-49.
Title: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.
Author: Ebert, Bettina|Kisiela, Michael|Wsol, Vladimir|Maser, Edmund
PMID: 21215737
33.
Journal: Toxicol In Vitro. 2011 Apr;25(3):671-83.
Title: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.
Author: Niestroy, Jeanette|Barbara, Alfonso|Herbst, Kathrin|Rode, Sandra|van Liempt, Manuela|Roos, Peter H
PMID: 21256954
34.
Journal: Expert Opin Ther Targets. 2011 Mar;15(3):281-95.
Title: Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.
Author: Saw, Constance Lay Lay|Kong, Ah-Ng Tony
PMID: 21261563
35.
Journal: Cancer Res. 2011 Mar 15;71(6):2260-75.
Title: NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha.
Author: Kim, Tae-Hyoung|Hur, Eu-gene|Kang, Su-Jin|Kim, Jung-Ae|Thapa, Dinesh|Lee, You Mie|Ku, Sae Kwang|Jung, Yunjin|Kwak, Mi-Kyoung
PMID: 21278237
36.
Journal: J Agric Food Chem. 2011 Mar 23;59(6):2725-33.
Title: Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway.
Author: Chiou, Yi-Siou|Tsai, Mei-Ling|Nagabhushanam, Kalyanam|Wang, Yin-Jen|Wu, Chih-Hsiung|Ho, Chi-Tang|Pan, Min-Hsiung
PMID: 21355597
37.
Journal: Arch Toxicol. 2011 Apr;85(4):273-84.
Title: Nrf2: control of sensitivity to carcinogens.
Author: Slocum, Stephen L|Kensler, Thomas W
PMID: 21369766
38.
Journal: Cell Signal. 2011 Sep;23(9):1505-13.
Title: An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-kappaB-independent mechanism.
Author: Min, Kyoung-jin|Lee, Jung Tae|Joe, Eun-hye|Kwon, Taeg Kyu
PMID: 21620964
39.
Journal: Carcinogenesis. 2012 Mar;33(3):620-8.
Title: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.
Author: Krehl, Susanne|Loewinger, Maria|Florian, Simone|Kipp, Anna P|Banning, Antje|Wessjohann, Ludger A|Brauer, Martin N|Iori, Renato|Esworthy, Robert S|Chu, Fong-Fong|Brigelius-Flohe, Regina
PMID: 22180572
40.
Journal: Food Chem Toxicol. 2012 Jul;50(7):2565-74.
Title: Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisp
Author: Lee, Chang Ki|Park, Kwang-Kyun|Chung, An-Sik|Chung, Won-Yoon
PMID: 22266358
41.
Journal: J Cell Biochem. 2012 Jun;113(6):2086-97.
Title: Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression.
Author: Shen, Ke|Cui, Daling|Sun, Liyun|Lu, Yanhua|Han, Mingquan|Liu, Jianwen
PMID: 22275271
42.
Journal: PLoS One. 2012;7(1):e29532.
Title: A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Author: Al-Mulla, Fahd|Bitar, Milad S|Feng, Jingwei|Park, Sungdae|Yeung, Kam C
PMID: 22279539
43.
Journal: BMC Cancer. 2012 Feb 13;12:66.
Title: Methylation of the KEAP1 gene promoter region in human colorectal cancer.
Author: Hanada, Naoyuki|Takahata, Takenori|Zhou, Qiliang|Ye, Xulu|Sun, Ruowen|Itoh, Jugoh|Ishiguro, Atsushi|Kijima, Hiroshi|Mimura, Junsei|Itoh, Ken|Fukuda, Shinsaku|Saijo, Yasuo
PMID: 22325485
44.
Journal: J Agric Food Chem. 2012 Apr 4;60(13):3441-51.
Title: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.
Author: Chiou, Yi-Shiou|Ma, Nianhan Jia-Lin|Sang, Shengmin|Ho, Chi-Tang|Wang, Ying-Jan|Pan, Min-Hsiung
PMID: 22409325
45.
Journal: Anticancer Drugs. 2012 Jul;23(6):651-8.
Title: The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors.
Author: Hu, Rong|Chen, Nan|Yao, Jing|Zhao, Qing|Zhang, Fengyi|Li, Zhi-Yu|You, Qi-Dong|Guo, Qing-Long
PMID: 22526619
46.
Journal: PLoS One. 2012;7(4):e35123.
Title: GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells.
Author: Chang, Yu-Jia|Huang, Yi-Ping|Li, Zih-Ling|Chen, Ching-Hsein
PMID: 22529978
47.
Journal: Chin J Physiol. 2012 Apr 30;55(2):134-44.
Title: Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells.
Author: Wang, Min|Chen, Shuo|Wang, Shuai|Sun, Defeng|Chen, Jian|Li, Yanqing|Han, Wei|Yang, Xiaoyun|Gao, Hai-Qing
PMID: 22559738
48.
Journal: Mol Pharm. 2012 Sep 4;9(9):2565-76.
Title: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins.
Author: Herraez, Elisa|Gonzalez-Sanchez, Ester|Vaquero, Javier|Romero, Marta R|Serrano, Maria A|Marin, Jose J G|Briz, Oscar
PMID: 22800197
49.
Journal: Mol Nutr Food Res. 2012 Sep;56(9):1477-81.
Title: Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-kappaB and regulating Nrf2/HO-1 pathway.
Author: Tuzcu, Mehmet|Aslan, Abdullah|Tuzcu, Zeynep|Yabas, Mehmet|Bahcecioglu, Ibrahim Halil|Ozercan, Ibrahim Hanifi|Kucuk, Omer|Sahin, Kazim
PMID: 22859375
50.
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2012 Aug;32(8):1093-7.
Title: [Small interfering RNA-mediated Nrf2 gene knockdown enhances hirsutanols A-induced cytotoxicity in cancer cells].
Author: Ma, Jianguo|Li, Houjin|Deng, Rong|Feng, Gongkan|Zhu, Xiaofeng
PMID: 22931598
51.
Journal: Zhonghua Nei Ke Za Zhi. 2012 Jul;51(7):531-5.
Title: [The UGT1A, Nrf2 and Keap1 protein expression and significance in colon tumor].
Author: Wang, Min|Qi, Ying-ying|Chen, Shuo|Liu, Liang|Chen, Jian|Li, Yan-qing
PMID: 22943825
52.
Journal: Nanotoxicology. 2013 Feb;7(1):2-20.
Title: DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells.
Author: Pelka, Joanna|Gehrke, Helge|Rechel, Anja|Kappes, Manfred|Hennrich, Frank|Hartinger, Christian G|Marko, Doris
PMID: 22007624
53.
Journal: Nanotoxicology. 2013 May;7(3):274-93.
Title: In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells.
Author: Gehrke, Helge|Fruhmesser, Anne|Pelka, Joanna|Esselen, Melanie|Hecht, Lena L|Blank, Holger|Schuchmann, Heike P|Gerthsen, Dagmar|Marquardt, Clarissa|Diabate, Silvia|Weiss, Carsten|Marko, Doris
PMID: 22264143
54.
Journal: Cancer Lett. 2013 Apr 28;330(2):225-32.
Title: Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC alpha/betaII by Gymnasterkoreayne B.
Author: Lee, Kyung-Mi|Kang, Kyungsu|Lee, Saet Byoul|Nho, Chu Won
PMID: 23219897
55.
Journal: Biol Trace Elem Res. 2013 Mar;151(3):384-99.
Title: Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats.
Author: Blum, Nicole M|Mueller, Kristin|Lippmann, Doris|Metges, Cornelia C|Linn, Thomas|Pallauf, Josef|Mueller, Andreas S
PMID: 23271678
56.
Journal: J Agric Food Chem. 2013 Mar 6;61(9):2158-64.
Title: Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan.
Author: Havermann, Susannah|Rohrig, Ricarda|Chovolou, Yvonni|Humpf, Hans-Ulrich|Watjen, Wim
PMID: 23339711
57.
Journal: Appl Immunohistochem Mol Morphol. 2013 Dec;21(6):511-7.
Title: Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue.
Author: Chang, Liang-Che|Fan, Chung-Wei|Tseng, Wen-Ko|Chen, Jim-Ray|Chein, Hui-Ping|Hwang, Cheng-Cheng|Hua, Chung-Ching
PMID: 23455180
58.
Journal: Mol Biol Cell. 2013 Jun;24(12):1852-62.
Title: Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.
Author: Volonte, Daniela|Liu, Zhongmin|Musille, Paul M|Stoppani, Elena|Wakabayashi, Nobunao|Di, Yuan-Pu|Lisanti, Michael P|Kensler, Thomas W|Galbiati, Ferruccio
PMID: 23637463
59.
Journal: Zhonghua Yi Xue Za Zhi. 2013 Feb 26;93(8):614-8.
Title: [Effects of autophagy modulator on autophagy and uridine 5'-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane].
Author: Wang, Min|Chen, Shuo|Qing, Ying|Wu, Dong|Lin, Ying-min|Chen, Jian|Li, Yan-qing
PMID: 23663345
60.
Journal: Oxid Med Cell Longev. 2013;2013:423965.
Title: Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells.
Author: Jung, Kyeong-Ah|Kwak, Mi-Kyoung
PMID: 23766854
61.
Journal: Eur J Med Chem. 2013 Aug;66:364-71.
Title: Synthesis and bioevaluation of a series of alpha-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I).
Author: Xi, Mei-yang|Sun, Zhong-ying|Sun, Hao-peng|Jia, Jian-min|Jiang, Zheng-yu|Tao, Lei|Ye, Ming|Yang, Xi|Wang, Ya-jing|Xue, Xin|Huang, Jing-jie|Gao, Yuan|Guo, Xiao-ke|Zhang, Sheng-lie|Yang, Ying-rui|Guo, Qing-long|Hu, Rong|You, Qi-dong
PMID: 23820128
62.
Journal: J Proteomics. 2013 Oct 8;91:84-96.
Title: The secretome of colon cancer stem cells contains drug-metabolizing enzymes.
Author: Emmink, Benjamin L|Verheem, Andre|Van Houdt, Winan J|Steller, Ernst J A|Govaert, Klaas M|Pham, Thang V|Piersma, Sander R|Borel Rinkes, Inne H M|Jimenez, Connie R|Kranenburg, Onno
PMID: 23835434
63.
Journal: J Biomed Res. 2013 Jul;27(4):283-90.
Title: Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer.
Author: Hu, Tinghua|Yao, Yu|Yu, Shuo|Guo, Hui|Han, Lili|Wang, Wenjuan|Tian, Tao|Hao, Yibin|Liu, Zhiyan|Nan, Kejun|Wang, Shuhong
PMID: 23885267
64.
Journal: Asian Pac J Cancer Prev. 2013;14(10):5543-52.
Title: Dietary non-nutritive factors in targeting of regulatory molecules in colorectal cancer: an update.
Author: Pandurangan, Ashok Kumar|Esa, Norhaizan Mohd
PMID: 24289544
65.
Journal: Mol Carcinog. 2014 Jan;53(1):77-84.
Title: Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation.
Author: Cheung, Ka Lung|Lee, Jong Hun|Khor, Tin Oo|Wu, Tien-Yuan|Li, Guang Xun|Chan, Jefferson|Yang, Chung S|Kong, Ah-Ng Tony
PMID: 22911891
66.
Journal: Toxicol Mech Methods. 2014 Jan;24(1):13-20.
Title: Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling.
Author: Pandurangan, Ashok Kumar|Ananda Sadagopan, Suresh Kumar|Dharmalingam, Prakash|Ganapasam, Sudhandiran
PMID: 24024667
67.
Journal: J Biol Chem. 2014 Jan 24;289(4):1917-29.
Title: Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
Author: Stachel, Imke|Geismann, Claudia|Aden, Konrad|Deisinger, Florian|Rosenstiel, Philip|Schreiber, Stefan|Sebens, Susanne|Arlt, Alexander|Schafer, Heiner
PMID: 24311782
68.
Journal: Biochim Biophys Acta. 2014 Jun;1840(6):1747-54.
Title: Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2.
Author: Geillinger, Kerstin E|Kipp, Anna P|Schink, Kristin|Roder, Pia V|Spanier, Britta|Daniel, Hannelore
PMID: 24380877
69.
Journal: Biochim Biophys Acta. 2014 Jun;1840(6):1808-16.
Title: A new tellurium-containing amphiphilic molecule induces apoptosis in HCT116 colon cancer cells.
Author: Du, Peng|Saidu, Nathaniel Edward Bennett|Intemann, Johanna|Jacob, Claus|Montenarh, Mathias
PMID: 24530428
70.
Journal: Free Radic Biol Med. 2014 May;70:68-77.
Title: Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs.
Author: Wang, Xiu Jun|Li, Yinyan|Luo, Lin|Wang, Hongyan|Chi, Zhexu|Xin, Ai|Li, Xin|Wu, Jiaguo|Tang, Xiuwen
PMID: 24556415
71.
Journal: Mol Cancer. 2014 Mar 6;13:48.
Title: Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation.
Author: Yang, Yang|Cai, Xueting|Yang, Jie|Sun, Xiaoyan|Hu, Chunping|Yan, Zhanpeng|Xu, Xiaojun|Lu, Wuguang|Wang, Xiaoning|Cao, Peng
PMID: 24602443
72.
Journal: Int J Clin Exp Pathol. 2014 Feb 15;7(3):1124-31. eCollection 2014.
Title: Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival.
Author: Ji, Lili|Wei, Yingze|Jiang, Tao|Wang, Shuyang
PMID: 24695690
73.
Journal: Food Funct. 2014 Jun;5(6):1073-81.
Title: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently.
Author: Lippmann, Doris|Lehmann, Carsten|Florian, Simone|Barknowitz, Gitte|Haack, Michael|Mewis, Inga|Wiesner, Melanie|Schreiner, Monika|Glatt, Hansruedi|Brigelius-Flohe, Regina|Kipp, Anna P
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Journal: Cell Death Dis. 2014 Apr 17;5:e1183.
Title: Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation.
Author: Kang, K A|Piao, M J|Kim, K C|Kang, H K|Chang, W Y|Park, I C|Keum, Y S|Surh, Y J|Hyun, J W
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Journal: Asian Pac J Cancer Prev. 2014;15(6):2911-6.
Title: Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway.
Author: Chian, Song|Li, Yin-Yan|Wang, Xiu-Jun|Tang, Xiu-Wen
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Journal: Int J Oncol. 2014 Jul;45(1):426-38.
Title: Evaluation of 2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/Keap1 pathway.
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Journal: Cell Death Dis. 2014 Jun 5;5:e1283.
Title: NF-kappaB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis.
Author: Yao, J|Zhao, L|Zhao, Q|Zhao, Y|Sun, Y|Zhang, Y|Miao, H|You, Q-D|Hu, R|Guo, Q-L
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Journal: PLoS One. 2014 Jun 25;9(6):e100256.
Title: Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway.
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Journal: Inflamm Bowel Dis. 2014 Sep;20(9):1530-47.
Title: Implications of the colonic deposition of free hemoglobin-alpha chain: a previously unknown tissue by-product in inflammatory bowel disease.
Author: Myers, Jeremy N|Schaffer, Michael W|Korolkova, Olga Y|Williams, Amanda D|Gangula, Pandu R|M'Koma, Amosy E
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Journal: Biochim Biophys Acta. 2014 Dec;1843(12):2827-37.
Title: Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2-ASK1 apoptosis pathways and oxidative stress is mitigated by Srx-Nrf2 anti-oxidant system.
Author: Ishaq, Musarat|Evans, Margaret D M|Ostrikov, Kostya Ken
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Journal: PLoS One. 2014 Sep 16;9(9):e107158.
Title: The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing.
Author: Choi, Bo-hyun|Ryoo, In-geun|Kang, Han Chang|Kwak, Mi-Kyoung
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Journal: Oncol Lett. 2014 Dec;8(6):2407-2416.
Title: Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.
Author: Wang, Min|Zhu, Jing-Yu|Chen, Shuo|Qing, Ying|Wu, Dong|Lin, Ying-Min|Luo, Ji-Zhuang|Han, Wei|Li, Yan-Qing
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Journal: Anat Rec (Hoboken). 2015 Feb;298(2):376-85.
Title: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells.
Author: Xu, Dao Gun|Lv, Wang|Dai, Chun Yan|Zhu, Fan Fan|Xu, Gua Hua|Ma, Zhong Jun|Chen, Zhe
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Journal: J Biochem Mol Toxicol. 2015 Jan;29(1):10-20.
Title: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.
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Journal: Pharm Biol. 2015 Apr;53(4):503-11.
Title: Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells.
Author: Zhang, Benping|Zhao, Jie|Li, Shanshan|Zeng, Linglan|Chen, Yan|Fang, Jun
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86.
Journal: Biofactors. 2015 Jan-Feb;41(1):1-14.
Title: Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway.
Author: Pandurangan, Ashok Kumar|Saadatdoust, Zeinab|Esa, Norhaizan Mohd|Hamzah, Hazilawati|Ismail, Amin
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87.
Journal: Nutr Cancer. 2015;67(3):494-503.
Title: Natural grape extracts regulate colon cancer cells malignancy.
Author: Signorelli, Paola|Fabiani, Carlotta|Brizzolari, Andrea|Paroni, Rita|Casas, Josefina|Fabrias, Gemma|Rossi, Dario|Ghidoni, Riccardo|Caretti, Anna
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Journal: Cancer Prev Res (Phila). 2015 May;8(5):444-54.
Title: Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.
Author: Long, Min|Tao, Shasha|Rojo de la Vega, Montserrat|Jiang, Tao|Wen, Qing|Park, Sophia L|Zhang, Donna D|Wondrak, Georg T
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Journal: Food Funct. 2015 Jul;6(7):2331-8.
Title: Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation.
Author: Shan, Shuhua|Shi, Jiangying|Li, Zhen|Gao, Huixian|Shi, Tonglin|Li, Zongwei|Li, Zhuoyu
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90.
Journal: Inflamm Bowel Dis. 2015 Sep;21(9):2078-89.
Title: GPx2 Induction Is Mediated Through STAT Transcription Factors During Acute Colitis.
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PMID: 26115075
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Journal: World J Gastroenterol. 2015 Aug 7;21(29):8826-35.
Title: Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats.
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Journal: Clin Epigenetics. 2015 Sep 18;7:102.
Title: Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
Author: Rajendran, Praveen|Dashwood, Wan-Mohaiza|Li, Li|Kang, Yuki|Kim, Eunah|Johnson, Gavin|Fischer, Kay A|Lohr, Christiane V|Williams, David E|Ho, Emily|Yamamoto, Masayuki|Lieberman, David A|Dashwood, Roderick H
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93.
Journal: Biochimie. 2015 Dec;119:103-12.
Title: Taxifolin curbs NF-kappaB-mediated Wnt/beta-catenin signaling via up-regulating Nrf2 pathway in experimental colon carcinogenesis.
Author: Manigandan, Krishnan|Manimaran, Dharmar|Jayaraj, Richard L|Elangovan, Namasivayam|Dhivya, Velumani|Kaphle, Anubhav
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Journal: Oncol Lett. 2015 Sep;10(3):1287-1292.
Title: Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells.
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Journal: Asian Pac J Cancer Prev. 2015;16(17):7943-57.
Title: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes.
Author: Elkady, Ayman I|Hussein, Rania A|El-Assouli, Sufian M
PMID: 26625825
96.
Journal: Free Radic Res. 2016;50(1):1-13.
Title: The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells.
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PMID: 26530909
97.
Journal: Free Radic Biol Med. 2016 Jan;90:158-72.
Title: DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy.
Author: Pettersen, Kristine|Monsen, Vivi Talstad|Hakvag Pettersen, Caroline Hild|Overland, Hilde Bremseth|Pettersen, Grete|Samdal, Helle|Tesfahun, Almaz Nigatu|Lundemo, Anne Goril|Bjorkoy, Geir|Schonberg, Svanhild A
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98.
Journal: Tumour Biol. 2016 Jun;37(6):8413-23.
Title: Reactive oxygen species mediate oxaliplatin-induced epithelial-mesenchymal transition and invasive potential in colon cancer.
Author: Jiao, Lin|Li, Dan-Dan|Yang, Chen-Lu|Peng, Rui-Qing|Guo, Yi-Qun|Zhang, Xiao-Shi|Zhu, Xiao-Feng
PMID: 26733168
99.
Journal: Cancer Med. 2016 Jun;5(6):1228-38.
Title: Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice.
Author: Yokoo, Yuh|Kijima, Aki|Ishii, Yuji|Takasu, Shinji|Tsuchiya, Takuma|Umemura, Takashi
PMID: 26899729
100.
Journal: J Immunol. 2016 Apr 15;196(8):3470-8.
Title: Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2.
Author: Beury, Daniel W|Carter, Kayla A|Nelson, Cassandra|Sinha, Pratima|Hanson, Erica|Nyandjo, Maeva|Fitzgerald, Phillip J|Majeed, Amry|Wali, Neha|Ostrand-Rosenberg, Suzanne
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Journal: Invest New Drugs. 2016 Jun;34(3):261-8.
Title: Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines.
Author: Flocke, Lea S|Trondl, Robert|Jakupec, Michael A|Keppler, Bernhard K
PMID: 26988975
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Journal: Carcinogenesis. 2016 Jun;37(6):635-645.
Title: Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats.
Author: Surya, Reggie|Helies-Toussaint, Cecile|Martin, Oceane C|Gauthier, Thierry|Gueraud, Francoise|Tache, Sylviane|Naud, Nathalie|Jouanin, Isabelle|Chantelauze, Celine|Durand, Denys|Joly, Charlotte|Pujos-Guillot, Estelle|Pierre, Fabrice H|Huc, Laurence
PMID: 26992899
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Journal: Free Radic Biol Med. 2016 Jun;95:121-32.
Title: Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4.
Author: Lin, Po-Lin|Chang, Jinghua Tsai|Wu, De-Wei|Huang, Chi-Chou|Lee, Huei
PMID: 27033953
104.
Journal: Oncogene. 2016 Nov 3;35(44):5795-5806.
Title: Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer.
Author: Yang, Y|Huycke, M M|Herman, T S|Wang, X
PMID: 27065323
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Journal: J Proteome Res. 2016 Jun 3;15(6):1971-85.
Title: Comprehensive Proteomic Study of the Antiproliferative Activity of a Polyphenol-Enriched Rosemary Extract on Colon Cancer Cells Using Nanoliquid Chromatography-Orbitrap MS/MS.
Author: Valdes, Alberto|Artemenko, Konstantin A|Bergquist, Jonas|Garcia-Canas, Virginia|Cifuentes, Alejandro
PMID: 27103343
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Journal: Pharm Biol. 2016 Sep;54(9):1491-502.
Title: Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein.
Author: Havermann, Susannah|Chovolou, Yvonni|Humpf, Hans-Ulrich|Watjen, Wim
PMID: 27143122
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Journal: Sci Rep. 2016 May 24;6:26585.
Title: An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis.
Author: Lu, Meng-Chen|Ji, Jian-Ai|Jiang, Yong-Lin|Chen, Zhi-Yun|Yuan, Zhen-Wei|You, Qi-Dong|Jiang, Zheng-Yu
PMID: 27215610
108.
Journal: Biofactors. 2016 Nov 12;42(6):623-637.
Title: Genistein regulates tumor microenvironment and exhibits anticancer effect in dimethyl hydrazine-induced experimental colon carcinogenesis.
Author: Sekar, Vasudevan|Anandasadagopan, Suresh Kumar|Ganapasam, Sudhandiran
PMID: 27255553
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Journal: Oncotarget. 2016 Jun 28;7(26):40594-40620.
Title: Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells.
Author: Kang, Kyoung Ah|Piao, Mei Jing|Ryu, Yea Seong|Kang, Hee Kyoung|Chang, Weon Young|Keum, Young Sam|Hyun, Jin Won
PMID: 27259240
110.
Journal: Oncotarget. 2016 Jul 19;7(29):46219-46229.
Title: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer.
Author: Jang, Hyun Joo|Hong, Eun Mi|Kim, Mikang|Kim, Jae Hyun|Jang, Juah|Park, Se Woo|Byun, Hyun Wu|Koh, Dong Hee|Choi, Min Ho|Kae, Sea Hyub|Lee, Jin
PMID: 27323826
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Journal: Cancer Med. 2016 Sep;5(9):2544-57.
Title: Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells.
Author: Tanaka, Genki|Inoue, Ken-Ichi|Shimizu, Takayuki|Akimoto, Kazumi|Kubota, Keiichi
PMID: 27485632
112.
Journal: Nutr Cancer. 2016 Nov-Dec;68(8):1338-1348.
Title: Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells.
Author: Lubelska, Katarzyna|Wiktorska, Katarzyna|Mielczarek, Lidia|Milczarek, Malgorzata|Zbroinska-Bregisz, Ilona|Chilmonczyk, Zdzislaw
PMID: 27636860
113.
Journal: Inflamm Bowel Dis. 2016 Nov;22(11):2593-2606.
Title: Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes.
Author: Kruse, Marie-Luise|Friedrich, Martin|Arlt, Alexander|Rocken, Christoph|Egberts, Jan-Hendrik|Sebens, Susanne|Schafer, Heiner
PMID: 27661668
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Journal: Dis Markers. 2016;2016:8143465.
Title: The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer.
Author: Chang, Liang-Che|Fan, Chung-Wei|Tseng, Wen-Ko|Chein, Hui-Ping|Hsieh, Tsan-Yu|Chen, Jim-Ray|Hwang, Cheng-Cheng|Hua, Chung-Ching
PMID: 27999449
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Journal: Arch Toxicol. 2017 Feb;91(2):967-982.
Title: The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.
Author: Faust, Dagmar|Nikolova, Teodora|Watjen, Wim|Kaina, Bernd|Dietrich, Cornelia
PMID: 26856715
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Journal: Arch Toxicol. 2017 Mar;91(3):1485-1495.
Title: Cytotoxic effects of the anthraquinone derivatives 1'-deoxyrhodoptilometrin and (S)-(-)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.
Author: Watjen, Wim|Ebada, Sherif S|Bergermann, Anja|Chovolou, Yvonni|Totzke, Frank|Kubbutat, Michael H G|Lin, Wenhan|Proksch, Peter
PMID: 27473261
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Journal: Mol Cell Proteomics. 2017 Jan;16(1):8-22.
Title: Nano-liquid Chromatography-orbitrap MS-based Quantitative Proteomics Reveals Differences Between the Mechanisms of Action of Carnosic Acid and Carnosol in Colon Cancer Cells.
Author: Valdes, Alberto|Garcia-Canas, Virginia|Artemenko, Konstantin A|Simo, Carolina|Bergquist, Jonas|Cifuentes, Alejandro
PMID: 27834734
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Journal: Mol Nutr Food Res. 2017 Apr;61(4).
Title: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.
Author: Johnson, Gavin S|Li, Jia|Beaver, Laura M|Dashwood, W Mohaiza|Sun, Deqiang|Rajendran, Praveen|Williams, David E|Ho, Emily|Dashwood, Roderick H
PMID: 27860235
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Journal: Arch Pharm Res. 2017 Feb;40(2):231-239.
Title: 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.
Author: Seo, Kyuhwa|Ki, Sung Hwan|Park, Eun Young|Shin, Sang Mi
PMID: 28028695
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Journal: Free Radic Biol Med. 2017 Mar;104:75-103.
Title: Redox signaling in the gastrointestinal tract.
Author: Perez, Salvador|Talens-Visconti, Raquel|Rius-Perez, Sergio|Finamor, Isabela|Sastre, Juan
PMID: 28062361
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Journal: Free Radic Biol Med. 2017 Oct;111:196-208.
Title: 4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer.
Author: Gueraud, Francoise
PMID: 28065782
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Journal: Mol Cancer Ther. 2017 Mar;16(3):529-539.
Title: Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications.
Author: Saidu, Nathaniel Edward Bennett|Noe, Gaelle|Cerles, Olivier|Cabel, Luc|Kavian-Tessler, Niloufar|Chouzenoux, Sandrine|Bahuaud, Mathilde|Chereau, Christiane|Nicco, Carole|Leroy, Karen|Borghese, Bruno|Goldwasser, Francois|Batteux, Frederic|Alexandre, Jerome
PMID: 28069874
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Journal: J Nutr Biochem. 2017 Apr;42:17-25.
Title: Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression.
Author: Wu, Xian|Song, Mingyue|Gao, Zili|Sun, Yue|Wang, Minqi|Li, Fang|Zheng, Jinkai|Xiao, Hang
PMID: 28107678
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Journal: Antioxid Redox Signal. 2017 Nov 1;27(13):945-961.
Title: NFE2L2/NRF2 Activity Is Linked to Mitochondria and AMP-Activated Protein Kinase Signaling in Cancers Through miR-181c/Mitochondria-Encoded Cytochrome c Oxidase Regulation.
Author: Jung, Kyeong-Ah|Lee, Sujin|Kwak, Mi-Kyoung
PMID: 28383996
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Journal: Int J Mol Sci. 2017 Apr 17;18(4). pii: ijms18040851.
Title: Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice.
Author: Noma, Nobuharu|Fujii, Gen|Miyamoto, Shingo|Komiya, Masami|Nakanishi, Ruri|Shimura, Misato|Tanuma, Sei-Ichi|Mutoh, Michihiro
PMID: 28420165
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Journal: Free Radic Biol Med. 2017 Jul;108:715-724.
Title: Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid.
Author: Kang, Sookjin|Kim, Wooseong|Jeong, Seongkeun|Lee, Yonghyun|Nam, Joon|Lee, Sunyoung|Jung, Yunjin
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Journal: Molecules. 2017 May 6;22(5). pii: molecules22050756.
Title: Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice.
Author: Wang, Canhong|Huo, Xiaowei|Gao, Li|Sun, Guibo|Li, Cao
PMID: 28481246
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Journal: PLoS One. 2017 May 18;12(5):e0177549.
Title: The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review.
Author: Gonzalez-Donquiles, C|Alonso-Molero, J|Fernandez-Villa, T|Vilorio-Marques, L|Molina, A J|Martin, V
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Journal: Tumour Biol. 2017 Jun;39(6):1010428317705510.
Title: The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance.
Author: Sadeghi, Mohammad Reza|Jeddi, Farhad|Soozangar, Narges|Somi, Mohammad Hossein|Samadi, Nasser
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Journal: Beijing Da Xue Xue Bao Yi Xue Ban. 2017 Jun 18;49(3):383-387.
Title: [Effects of equol on colon cancer cell proliferation].
Author: Cai, Y F|Zhang, H M|Niu, W Y|Zou, Y Q|Ma, D F
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Journal: Nutr Cancer. 2017 Aug-Sep;69(6):855-861.
Title: Anticarcinogenic Effects of Dried Citrus Peel in Colon Carcinogenesis Due to Inhibition of Oxidative Stress.
Author: Onuma, Wakana|Asai, Daichi|Tomono, Susumu|Miyamoto, Shingo|Fujii, Gen|Hamoya, Takahiro|Nagano, Aya|Takahashi, Satoru|Masumori, Shoji|Miyoshi, Noriyuki|Wakabayashi, Keiji|Mutoh, Michihiro
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Journal: Oncol Rep. 2017 Sep;38(3):1637-1644.
Title: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway.
Author: Li, Siying|Yang, Guang|Zhu, Xiaosong|Cheng, Lin|Sun, Yueyue|Zhao, Zhongxi
PMID: 28737825
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Journal: Biosci Biotechnol Biochem. 2017 Nov;81(11):2212-2215.
Title: Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells.
Author: Liu, Xiaoyang|Abe-Kanoh, Naomi|Liu, Yujia|Zhu, Beiwei|Munemasa, Shintaro|Nakamura, Toshiyuki|Murata, Yoshiyuki|Nakamura, Yoshimasa
PMID: 28934922
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Journal: Cancer Lett. 2017 Dec 28;411:57-63.
Title: Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells.
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Journal: Biomark Med. 2017 Dec;11(12):1103-1111.
Title: The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer.
Author: Chang, Liang-Che|Fan, Chung-Wei|Tseng, Wen-Ko|Chein, Hui-Ping|Hsieh, Tsan-Yu|Chen, Jim-Ray|Hwang, Cheng-Cheng|Hua, Chung-Ching
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Journal: Oncogene. 2018 Jan 4;37(1):39-51.
Title: Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells.
Author: Diehl, K|Dinges, L-A|Helm, O|Ammar, N|Plundrich, D|Arlt, A|Rocken, C|Sebens, S|Schafer, H
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Journal: Pharmacol Ther. 2018 Jun;186:138-151.
Title: CCRK is a novel signalling hub exploitable in cancer immunotherapy.
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Journal: Biochem Pharmacol. 2018 Jul;153:282-291.
Title: Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis.
Author: Song, Na-Young|Lee, Yeon-Hwa|Na, Hye-Kyung|Baek, Jeong-Heum|Surh, Young-Joon
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Journal: Cancer Discov. 2018 May;8(5):632-647.
Title: Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.
Author: Port, Jennifer|Muthalagu, Nathiya|Raja, Meera|Ceteci, Fatih|Monteverde, Tiziana|Kruspig, Bjorn|Hedley, Ann|Kalna, Gabriela|Lilla, Sergio|Neilson, Lisa|Brucoli, Martina|Gyuraszova, Katarina|Tait-Mulder, Jacqueline|Mezna, Mokdad|Svambaryte, Silvija|Bryson,
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Journal: Oncotarget. 2018 Jan 10;9(10):9088-9099.
Title: Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells.
Author: Bennett Saidu, Nathaniel Edward|Bretagne, Marie|Mansuet, Audrey Lupo|Just, Pierre-Alexandre|Leroy, Karen|Cerles, Olivier|Chouzenoux, Sandrine|Nicco, Carole|Damotte, Diane|Alifano, Marco|Borghese, Bruno|Goldwasser, Francois|Batteux, Frederic|Alexandre, Jer
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Journal: Carcinogenesis. 2018 May 3;39(5):669-680.
Title: DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice.
Author: Guo, Yue|Wu, Renyi|Gaspar, John M|Sargsyan, Davit|Su, Zheng-Yuan|Zhang, Chengyue|Gao, Linbo|Cheng, David|Li, Wenji|Wang, Chao|Yin, Ran|Fang, Mingzhu|Verzi, Michael P|Hart, Ronald P|Kong, Ah-Ng
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Journal: Food Funct. 2018 Apr 25;9(4):2158-2170.
Title: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability.
Author: Afrin, Sadia|Giampieri, Francesca|Gasparrini, Massimiliano|Forbes-Hernandez, Tamara Y|Cianciosi, Danila|Reboredo-Rodriguez, Patricia|Manna, Piera Pia|Zhang, Jiaojiao|Quiles, Jose L|Battino, Maurizio
PMID: 29644357
143.
Journal: Biomed Pharmacother. 2018 Jul;103:755-766.
Title: The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells.
Author: Pirpour Tazehkand, Abbas|Akbarzadeh, Maryam|Velaie, Kobra|Sadeghi, Mohammad Reza|Samadi, Nasser
PMID: 29684854
144.
Journal: Food Funct. 2018 May 23;9(5):2809-2819.
Title: Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.
Author: Bi, Wu|He, Chun-Nian|Li, Xiao-Xiao|Zhou, Liu-Ying|Liu, Rui-Jie|Zhang, Sai|Li, Guo-Qing|Chen, Zhu-Chu|Zhang, Peng-Fei
PMID: 29693091
145.
Journal: Food Funct. 2018 May 23;9(5):2695-2704.
Title: Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice.
Author: Wang, Canhong|Yang, Shuxian|Gao, Li|Wang, Lili|Cao, Li
PMID: 29756138
146.
Journal: Int J Mol Sci. 2018 May 16;19(5). pii: ijms19051478.
Title: Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings.
Author: Sena, Paola|Mancini, Stefano|Benincasa, Marta|Mariani, Francesco|Palumbo, Carla|Roncucci, Luca
PMID: 29772687
147.
Journal: Biomed Pharmacother. 2018 Aug;104:458-464.
Title: Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer.
Author: Sadeghi, Mohammad Reza|Jeddi, Farhad|Soozangar, Narges|Somi, Mohammad Hossein|Shirmohamadi, Masoud|Khaze, Vahid|Samadi, Nasser
PMID: 29793178
148.
Journal: Oxid Med Cell Longev. 2018 May 20;2018:3271617.
Title: 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
Author: Xu, Li-Li|Liu, Tian|Wang, Lei|Li, Li|Wu, Yu-Feng|Li, Cui-Cui|Di, Bin|You, Qi-Dong|Jiang, Zheng-Yu
PMID: 29887940
149.
Journal: Oncotarget. 2018 May 29;9(41):26342-26352.
Title: PSMD4 is a novel therapeutic target in chemoresistant colorectal cancer activated by cytoplasmic localization of Nrf2.
Author: Cheng, Ya-Min|Lin, Po-Lin|Wu, De-Wei|Wang, Lee|Huang, Chi-Chou|Lee, Huei
PMID: 29899863
150.
Journal: Oncotarget. 2018 Jun 5;9(43):27104-27116.
Title: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Author: Evans, Jonathan P|Winiarski, Boleslaw K|Sutton, Paul A|Jones, Robert P|Ressel, Lorenzo|Duckworth, Carrie A|Pritchard, D Mark|Lin, Zhi-Xiu|Vicky, Fretwell L|Tweedle, Elizabeth M|Costello, Eithne|Goldring, Christopher E|Copple, Ian M|Park, B Kevin|Palmer, D
PMID: 29930754
151.
Journal: Front Immunol. 2018 Jun 27;9:1504.
Title: Pectin Oligosaccharides Ameliorate Colon Cancer by Regulating Oxidative Stress- and Inflammation-Activated Signaling Pathways.
Author: Tan, Haidong|Chen, Wei|Liu, Qishun|Yang, Guojun|Li, Kuikui
PMID: 30013563
152.
Journal: Am J Pathol. 2018 Oct;188(10):2369-2377.
Title: Increased Levels of Oxidative Damage in Liver Metastases Compared with Corresponding Primary Colorectal Tumors: Association with Molecular Subtype and Prior Treatment.
Author: van der Waals, Lizet M|Jongen, Jennifer M J|Elias, Sjoerd G|Veremiyenko, Kateryna|Trumpi, Kari|Trinh, Anne|Laoukili, Jamila|Ubink, Inge|Schenning-van Schelven, Susanne J|van Diest, Paul J|Borel Rinkes, Inne H M|Kranenburg, Onno
PMID: 30031728
153.
Journal: Free Radic Biol Med. 2018 Oct;126:41-54.
Title: Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability.
Author: Afrin, Sadia|Giampieri, Francesca|Forbes-Hernandez, Tamara Y|Gasparrini, Massimiliano|Amici, Adolfo|Cianciosi, Danila|Quiles, Jose L|Battino, Maurizio
PMID: 30056083
154.
Journal: Cancer Res Treat. 2018 Aug 1. pii: crt.2018.060.
Title: Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development.
Author: Son, Hee Jin|Sohn, Sung Hwa|Kim, Nayoung|Lee, Ha-Na|Lee, Sun Min|Nam, Ryoung Hee|Park, Ji Hyun|Song, Chin-Hee|Shin, Eun|Na, Hee Young|Kim, Joo Sung|Lee, Dong Ho|Surh, Young-Joon
PMID: 30064198
155.
Journal: J Cell Biochem. 2018 Aug 20.
Title: The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells.
Author: Zuo, Qian|Wu, Renyi|Xiao, Xi|Yang, Caizhi|Yang, Yuqing|Wang, Chao|Lin, Lizhu|Kong, Ah-Ng
PMID: 30129150
156.
Journal: Expert Rev Gastroenterol Hepatol. 2018 Sep 26:1-18.
Title: An update on dietary consideration in inflammatory bowel disease: anthocyanins and more.
Author: Farzaei, Mohammad Hosein|El-Senduny, Fardous F|Momtaz, Saeideh|Parvizi, Fatemeh|Iranpanah, Amin|Tewari, Devesh|Naseri, Rozita|Abdolghaffari, Amir Hossein|Rezaei, Nima
PMID: 30136591
157.
Journal: Cell Death Dis. 2018 Aug 30;9(9):896.
Title: High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling.
Author: Kim, Donghyeok|Choi, Bo-Hyun|Ryoo, In-Geun|Kwak, Mi-Kyoung
PMID: 30166520
158.
Journal: Curr Med Chem. 2018 Sep 3. pii: CMC-EPUB-92805.
Title: Close interplay of nitro-oxidative stress, advanced glycation end products and inflammation in inflammatory bowel diseases.
Author: Moura, Fabiana Andrea|Goulart, Marilia Oliveira Fonseca|da Paz Martins, Amylly Sanuelly|Campos, Samara Bonfim Gomes
PMID: 30182837
159.
Journal: Mar Drugs. 2018 Sep 23;16(10). pii: md16100347.
Title: Marine Peroxy Sesquiterpenoids Induce Apoptosis by Modulation of Nrf2-ARE Signaling in HCT116 Colon Cancer Cells.
Author: Taira, Junsei|Miyazato, Haruna|Ueda, Katsuhiro
PMID: 30249028
160.
Journal: Biochim Biophys Acta Mol Basis Dis. 2018 Sep 26;1864(12):3668-3678.
Title: Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
Author: Choo, Jieun|Heo, Gwangbeom|Kim, Su Jin|Lee, Yunna|Ishigami, Akihito|Maruyama, Naoki|Chung, Hae Young|Im, Eunok
PMID: 30266650
161.
Journal: Am J Chin Med. 2018 Oct 4:1-15.
Title: Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model.
Author: Fang, Ruoming|Wu, Renyi|Zuo, Qian|Yin, Ran|Zhang, Chengyue|Wang, Chao|Guo, Yue|Yang, Anne Yuqing|Li, Wenji|Lin, Lizhu|Kong, Ah-Ng
PMID: 30284461
162.
Journal: Mol Med Rep. 2018 Oct 24.
Title: Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT8/5Fu human colorectal cancer cell line.
Author: Zhang, Chao|He, Lian-Jun|Ye, Hai-Zhu|Liu, Ding-Feng|Zhu, Yi-Bao|Miao, Dong-Dong|Zhang, Sheng-Peng|Chen, Yun-Yu|Jia, Yuan-Wei|Shen, Jie|Liu, Xiao-Ping
PMID: 30365132