Primary Site >> Colorectal Cancer
Gene >> NFE2L2
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Ref: Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents. PMID: 12818365 |
Ref: [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells]. PMID: 15949398 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. PMID: 16083918 |
Ref: [The role of NF-E2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1A and its isoforms by epigallocatechin gallate in colon cancer cells]. PMID: 16620709 Ref: Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. PMID: 17178849 Ref: Cancer chemopreventive agents-drugs for the 21st century? PMID: 17357586 |
Ref: The use of nitric oxide-donating nonsteroidal anti-inflammatory drugs in the chemoprevention of colorectal neoplasia. PMID: 17133086 Ref: Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. PMID: 17390011 Ref: Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice. PMID: 17657175 Ref: Novel agents for cancer prevention based on nitric oxide. PMID: 17956352 |
Ref: Curcumin: from ancient medicine to current clinical trials. PMID: 18324353 Ref: The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population. PMID: 18444152 Ref: GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. PMID: 18479189 Ref: Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. PMID: 18694732 Ref: Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway. PMID: 18937168 Ref: Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. PMID: 19138955 |
Ref: Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells. PMID: 19524433 Ref: Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. PMID: 19706542 Ref: Modulation of NRF2 and UGT1A expression by epigallocatechin-3-gallate in colon cancer cells and BALB/c mice. PMID: 19719968 Ref: Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). PMID: 19734940 |
Ref: Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. PMID: 19833168 Ref: Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM. PMID: 19959557 Ref: [Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells]. PMID: 20175231 Ref: The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. PMID: 20657484 Ref: Redox regulation in cancer: a double-edged sword with therapeutic potential. PMID: 20716925 Ref: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. PMID: 20924967 Ref: Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. PMID: 20924970 Ref: Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways. PMID: 20930371 |
Ref: Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. PMID: 20655719 Ref: Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. PMID: 20967519 Ref: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. PMID: 21215737 Ref: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. PMID: 21256954 Ref: Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer. PMID: 21261563 Ref: NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha. PMID: 21278237 Ref: Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. PMID: 21355597 Ref: Nrf2: control of sensitivity to carcinogens. PMID: 21369766 Ref: An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-kappaB-independent mechanism. PMID: 21620964 |
Ref: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply. PMID: 22180572 Ref: Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisp PMID: 22266358 Ref: Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression. PMID: 22275271 Ref: A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. PMID: 22279539 Ref: Methylation of the KEAP1 gene promoter region in human colorectal cancer. PMID: 22325485 Ref: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. PMID: 22409325 Ref: The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors. PMID: 22526619 Ref: GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. PMID: 22529978 Ref: Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells. PMID: 22559738 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-kappaB and regulating Nrf2/HO-1 pathway. PMID: 22859375 Ref: [Small interfering RNA-mediated Nrf2 gene knockdown enhances hirsutanols A-induced cytotoxicity in cancer cells]. PMID: 22931598 Ref: [The UGT1A, Nrf2 and Keap1 protein expression and significance in colon tumor]. PMID: 22943825 |
Ref: DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells. PMID: 22007624 Ref: In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells. PMID: 22264143 Ref: Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC alpha/betaII by Gymnasterkoreayne B. PMID: 23219897 Ref: Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. PMID: 23271678 Ref: Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan. PMID: 23339711 Ref: Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue. PMID: 23455180 Ref: Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. PMID: 23637463 Ref: [Effects of autophagy modulator on autophagy and uridine 5'-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane]. PMID: 23663345 Ref: Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells. PMID: 23766854 Ref: Synthesis and bioevaluation of a series of alpha-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I). PMID: 23820128 Ref: The secretome of colon cancer stem cells contains drug-metabolizing enzymes. PMID: 23835434 Ref: Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer. PMID: 23885267 Ref: Dietary non-nutritive factors in targeting of regulatory molecules in colorectal cancer: an update. PMID: 24289544 |
Ref: Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. PMID: 22911891 Ref: Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling. PMID: 24024667 Ref: Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress. PMID: 24311782 Ref: Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2. PMID: 24380877 Ref: A new tellurium-containing amphiphilic molecule induces apoptosis in HCT116 colon cancer cells. PMID: 24530428 Ref: Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs. PMID: 24556415 Ref: Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation. PMID: 24602443 Ref: Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival. PMID: 24695690 Ref: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. PMID: 24714741 Ref: Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation. PMID: 24743738 Ref: Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway. PMID: 24761924 Ref: Evaluation of 2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/Keap1 pathway. PMID: 24788124 Ref: NF-kappaB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. PMID: 24901054 Ref: Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway. PMID: 24964141 Ref: Implications of the colonic deposition of free hemoglobin-alpha chain: a previously unknown tissue by-product in inflammatory bowel disease. PMID: 25078150 Ref: Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2-ASK1 apoptosis pathways and oxidative stress is mitigated by Srx-Nrf2 anti-oxidant system. PMID: 25173814 Ref: The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing. PMID: 25226504 Ref: Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. PMID: 25364403 |
Ref: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. PMID: 25178491 Ref: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite. PMID: 25179160 Ref: Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. PMID: 25380307 Ref: Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway. PMID: 25545372 Ref: Natural grape extracts regulate colon cancer cells malignancy. PMID: 25705818 Ref: Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. PMID: 25712056 Ref: Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation. PMID: 26075747 Ref: GPx2 Induction Is Mediated Through STAT Transcription Factors During Acute Colitis. PMID: 26115075 Ref: Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats. PMID: 26269672 Ref: Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. PMID: 26388957 Ref: Taxifolin curbs NF-kappaB-mediated Wnt/beta-catenin signaling via up-regulating Nrf2 pathway in experimental colon carcinogenesis. PMID: 26482805 Ref: Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells. PMID: 26622665 Ref: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes. PMID: 26625825 |
Ref: The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells. PMID: 26530909 Ref: DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy. PMID: 26585906 Ref: Reactive oxygen species mediate oxaliplatin-induced epithelial-mesenchymal transition and invasive potential in colon cancer. PMID: 26733168 Ref: Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice. PMID: 26899729 Ref: Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2. PMID: 26936880 Ref: Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines. PMID: 26988975 Ref: Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats. PMID: 26992899 Ref: Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4. PMID: 27033953 Ref: Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer. PMID: 27065323 Ref: Comprehensive Proteomic Study of the Antiproliferative Activity of a Polyphenol-Enriched Rosemary Extract on Colon Cancer Cells Using Nanoliquid Chromatography-Orbitrap MS/MS. PMID: 27103343 Ref: Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein. PMID: 27143122 Ref: An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. PMID: 27215610 Ref: Genistein regulates tumor microenvironment and exhibits anticancer effect in dimethyl hydrazine-induced experimental colon carcinogenesis. PMID: 27255553 Ref: Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells. PMID: 27259240 Ref: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. PMID: 27323826 Ref: Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells. PMID: 27485632 Ref: Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells. PMID: 27636860 Ref: Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes. PMID: 27661668 Ref: The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. PMID: 27999449 |
Ref: The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation. PMID: 26856715 Ref: Cytotoxic effects of the anthraquinone derivatives 1'-deoxyrhodoptilometrin and (S)-(-)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp. PMID: 27473261 Ref: Nano-liquid Chromatography-orbitrap MS-based Quantitative Proteomics Reveals Differences Between the Mechanisms of Action of Carnosic Acid and Carnosol in Colon Cancer Cells. PMID: 27834734 Ref: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. PMID: 27860235 Ref: 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells. PMID: 28028695 Ref: Redox signaling in the gastrointestinal tract. PMID: 28062361 Ref: 4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer. PMID: 28065782 Ref: Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications. PMID: 28069874 Ref: Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression. PMID: 28107678 Ref: NFE2L2/NRF2 Activity Is Linked to Mitochondria and AMP-Activated Protein Kinase Signaling in Cancers Through miR-181c/Mitochondria-Encoded Cytochrome c Oxidase Regulation. PMID: 28383996 Ref: Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. PMID: 28420165 Ref: Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid. PMID: 28473247 Ref: Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice. PMID: 28481246 Ref: The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review. PMID: 28542357 Ref: The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance. PMID: 28621229 Ref: [Effects of equol on colon cancer cell proliferation]. PMID: 28628136 Ref: Anticarcinogenic Effects of Dried Citrus Peel in Colon Carcinogenesis Due to Inhibition of Oxidative Stress. PMID: 28718722 Ref: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. PMID: 28737825 Ref: Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells. PMID: 28934922 Ref: Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells. PMID: 28986187 Ref: The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer. PMID: 29053012 |
Ref: Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells. PMID: 28846107 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis. PMID: 29427626 Ref: Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress. PMID: 29500295 Ref: Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells. PMID: 29507676 Ref: DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. PMID: 29547900 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability. PMID: 29644357 Ref: The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells. PMID: 29684854 Ref: Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway. PMID: 29693091 Ref: Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice. PMID: 29756138 Ref: Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings. PMID: 29772687 Ref: Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer. PMID: 29793178 Ref: 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation. PMID: 29887940 Ref: PSMD4 is a novel therapeutic target in chemoresistant colorectal cancer activated by cytoplasmic localization of Nrf2. PMID: 29899863 Ref: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. PMID: 29930754 Ref: Pectin Oligosaccharides Ameliorate Colon Cancer by Regulating Oxidative Stress- and Inflammation-Activated Signaling Pathways. PMID: 30013563 Ref: Increased Levels of Oxidative Damage in Liver Metastases Compared with Corresponding Primary Colorectal Tumors: Association with Molecular Subtype and Prior Treatment. PMID: 30031728 Ref: Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. PMID: 30056083 Ref: Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development. PMID: 30064198 Ref: The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells. PMID: 30129150 Ref: An update on dietary consideration in inflammatory bowel disease: anthocyanins and more. PMID: 30136591 Ref: High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling. PMID: 30166520 Ref: Close interplay of nitro-oxidative stress, advanced glycation end products and inflammation in inflammatory bowel diseases. PMID: 30182837 Ref: Marine Peroxy Sesquiterpenoids Induce Apoptosis by Modulation of Nrf2-ARE Signaling in HCT116 Colon Cancer Cells. PMID: 30249028 Ref: Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity. PMID: 30266650 Ref: Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model. PMID: 30284461 Ref: Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT8/5Fu human colorectal cancer cell line. PMID: 30365132 |