Primary Site >> Colorectal Cancer

Gene >> NAT1

Journal: Carcinogenesis. 1991 Aug;12(8):1465-9.
Title: Distribution of acetyltransferase activities in the intestines of rapid and slow acetylator rabbits.
Author: Ilett, K F|Reeves, P T|Minchin, R F|Kinnear, B F|Watson, H F|Kadlubar, F F
PMID: 1860167
Journal: Toxicol Lett. 1992 Dec;64-65 Spec No:123-30.
Title: Acetyltransferases and susceptibility to chemicals.
Author: Hein, D W|Rustan, T D|Doll, M A|Bucher, K D|Ferguson, R J|Feng, Y|Furman, E J|Gray, K
PMID: 1471166
Journal: Arch Toxicol. 1993;67(7):445-52.
Title: Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.
Author: Rodriguez, J W|Kirlin, W G|Ferguson, R J|Doll, M A|Gray, K|Rustan, T D|Lee, M E|Kemp, K|Urso, P|Hein, D W
PMID: 7902079
Journal: Cancer Res. 1995 Nov 15;55(22):5226-9.
Title: Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue.
Author: Bell, D A|Badawi, A F|Lang, N P|Ilett, K F|Kadlubar, F F|Hirvonen, A
PMID: 7585580
Journal: Cancer Res. 1995 Aug 15;55(16):3537-42.
Title: Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer.
Author: Bell, D A|Stephens, E A|Castranio, T|Umbach, D M|Watson, M|Deakin, M|Elder, J|Hendrickse, C|Duncan, H|Strange, R C
PMID: 7627961
Journal: Prog Clin Biol Res. 1996;395:109-40.
Title: Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility.
Author: Badawi, A F|Stern, S J|Lang, N P|Kadlubar, F F
PMID: 8895986
Journal: Cancer Epidemiol Biomarkers Prev. 1997 Apr;6(4):225-31.
Title: Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.
Author: Okkels, H|Sigsgaard, T|Wolf, H|Autrup, H
PMID: 9107426
Journal: Mutat Res. 1997 May 12;376(1-2):101-6.
Title: Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases.
Author: Hein, D W|Doll, M A|Fretland, A J|Gray, K|Deitz, A C|Feng, Y|Jiang, W|Rustan, T D|Satran, S L|Wilkie, T R Sr
PMID: 9202744
Journal: Mutat Res. 1997 May 12;376(1-2):153-60.
Title: The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.
Author: Windmill, K F|McKinnon, R A|Zhu, X|Gaedigk, A|Grant, D M|McManus, M E
PMID: 9202751
Journal: Br J Cancer. 1998 Mar;77(6):913-6.
Title: N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients.
Author: Hubbard, A L|Moyes, C|Wyllie, A H|Smith, C A|Harrison, D J
PMID: 9528834
Journal: Gut. 1998 Mar;42(3):402-9.
Title: Expression of arylamine N-acetyltransferase in human intestine.
Author: Hickman, D|Pope, J|Patil, S D|Fakis, G|Smelt, V|Stanley, L A|Payton, M|Unadkat, J D|Sim, E
PMID: 9577349
Journal: Cancer Res. 1998 Aug 1;58(15):3307-11.
Title: A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.
Author: Chen, J|Stampfer, M J|Hough, H L|Garcia-Closas, M|Willett, W C|Hennekens, C H|Kelsey, K T|Hunter, D J
PMID: 9699660
Journal: Pharmacogenetics. 1998 Aug;8(4):299-304.
Title: Detection of mutations and polymorphism of N-acetyltransferase 1 gene in Indian, Malay and Chinese populations.
Author: Zhao, B|Lee, E J|Yeoh, P N|Gong, N H
PMID: 9731716
Journal: Gastroenterology. 1998 Dec;115(6):1387-94.
Title: Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.
Author: Moisio, A L|Sistonen, P|Mecklin, J P|Jarvinen, H|Peltomaki, P
PMID: 9834266
Journal: Recent Results Cancer Res. 1998;154:47-85.
Title: Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Author: Hengstler, J G|Arand, M|Herrero, M E|Oesch, F
PMID: 10026993
Journal: Eur J Cancer Prev. 1999 Jul;8(3):207-11.
Title: Meat, metabolic genotypes and risk for colorectal cancer.
Author: Roberts-Thomson, I C|Butler, W J|Ryan, P
PMID: 10443949
Journal: IARC Sci Publ. 1999;(148):251-70.
Title: Polymorphic NATs and cancer predisposition.
Author: Hirvonen, A
PMID: 10493262
Journal: Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42.
Title: Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.
Author: Hein, D W|Doll, M A|Fretland, A J|Leff, M A|Webb, S J|Xiao, G H|Devanaboyina, U S|Nangju, N A|Feng, Y
PMID: 10667461
Journal: Am J Epidemiol. 2000 May 1;151(9):846-61.
Title: N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review.
Author: Brockton, N|Little, J|Sharp, L|Cotton, S C
PMID: 10791558
Journal: J Gastroenterol Hepatol. 2001 Jun;16(6):631-5.
Title: Metabolic genotypes and risk for colorectal cancer.
Author: Butler, W J|Ryan, P|Roberts-Thomson, I C
PMID: 11422615
Journal: Gastroenterology. 2001 Aug;121(2):282-301.
Title: Polymorphisms and colorectal tumor risk.
Author: Houlston, R S|Tomlinson, I P
PMID: 11487538
Journal: Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1259-66.
Title: Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk.
Author: Le Marchand, L|Hankin, J H|Wilkens, L R|Pierce, L M|Franke, A|Kolonel, L N|Seifried, A|Custer, L J|Chang, W|Lum-Jones, A|Donlon, T
PMID: 11751443
Journal: Cancer Causes Control. 2002 May;13(4):383-93.
Title: Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study.
Author: Tiemersma, Edine W|Kampman, Ellen|Bueno de Mesquita, H B|Bunschoten, Annelies|van Schothorst, Evert M|Kok, Frans J|Kromhout, Daan
PMID: 12074508
Journal: Mutat Res. 2002 Sep 30;506-507:65-77.
Title: Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.
Author: Hein, David W
PMID: 12351146
Journal: Am J Prev Med. 2003 Feb;24(2):170-6.
Title: Family history of colon cancer: what does it mean and how is it useful?
Author: Keku, Temitope O|Millikan, Robert C|Martin, Chris|Rahkra-Burris, Tejinder K|Sandler, Robert S
PMID: 12568823
Journal: Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):681-2.
Title: No modifying effect of NAT1, GSTM1, and GSTT1 on the relation between smoking and colorectal cancer risk.
Author: van der Hel, Olga L|Bueno de Mesquita, H Bas|Roest, Mark|Slothouber, Barbara|van Gils, Carla|van Noord, Paulus A H|Grobbee, Diederick E|Peeters, Petra H M
PMID: 12869413
Journal: In Vivo. 2003 May-Jun;17(3):301-9.
Title: Curcumin decreases the DNA adduct formation, arylamines N-acetyltransferase activity and gene expression in human colon tumor cells (colo 205).
Author: Chen, Jung-Chou|Hwang, Jiunn-Ming|Chen, Guang-Wei|Tsou, Mei-Fen|Hsia, Te-Chun|Chung, Jing-Gung
PMID: 12929584
Journal: Int J Cancer. 2003 Dec 20;107(6):878-84.
Title: Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes.
Author: Magagnotti, Cinzia|Pastorelli, Roberta|Pozzi, Simonetta|Andreoni, Bruno|Fanelli, Roberto|Airoldi, Luisa
PMID: 14601045
Journal: Gut. 2004 Feb;53(2):271-6.
Title: Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.
Author: Crabtree, M D|Fletcher, C|Churchman, M|Hodgson, S V|Neale, K|Phillips, R K S|Tomlinson, I P M
PMID: 14724163
Journal: Cancer Res Treat. 2004 Apr;36(2):93-9.
Title: Molecular epidemiology of colon cancer.
Author: Kim, Dong-Hyun|Ahn, Yoon-Ok
PMID: 20396547
Journal: Anticancer Res. 2004 Nov-Dec;24(6):3965-70.
Title: Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer.
Author: Kiss, Istvan|Nemeth, Arpad|Bogner, Barna|Pajkos, Gabor|Orsos, Zsuzsa|Sandor, Janos|Csejtey, Andras|Faluhelyi, Zsolt|Rodler, Imre|Ember, Istvan
PMID: 15736440
Journal: World J Gastroenterol. 2005 Jan 21;11(3):331-5.
Title: Relationship between metabolic enzyme polymorphism and colorectal cancer.
Author: Chen, Kun|Jiang, Qin-Ting|He, Han-Qing
PMID: 15637738
Journal: Pharmacogenet Genomics. 2005 Aug;15(8):535-46.
Title: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
Author: Landi, Stefano|Gemignani, Federica|Moreno, Victor|Gioia-Patricola, Lydie|Chabrier, Amelie|Guino, Elisabeth|Navarro, Matilde|de Oca, Javier|Capella, Gabriel|Canzian, Federico
PMID: 16006997
Journal: Melanoma Res. 2005 Dec;15(6):489-94.
Title: Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2).
Author: Lin, Shuw-Yuan|Yang, Jen-Hung|Hsia, Te-Chun|Lee, Jau-Hong|Chiu, Tsan-Hung|Wei, Yau-Huei|Chung, Jing-Gung
PMID: 16314733
Journal: Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Sep;26(9):659-64.
Title: [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer].
Author: Chen, Kun|Jin, Ming-juan|Fan, Chun-hong|Song, Liang|Jiang, Qin-ting|Yu, Wei-ping|Ma, Xin-yuan|Yao, Kai-yan
PMID: 16471212
Journal: Br J Nutr. 2006 Oct;96(4):609-19.
Title: Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility.
Author: Reszka, Edyta|Wasowicz, Wojciech|Gromadzinska, Jolanta
PMID: 17010218
Journal: Carcinogenesis. 2007 Feb;28(2):328-41.
Title: Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps.
Author: Goode, Ellen L|Potter, John D|Bamlet, William R|Rider, David N|Bigler, Jeannette
PMID: 16926176
Journal: J Biomed Sci. 2007 Mar;14(2):183-93. Epub 2006 Dec 27.
Title: Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan.
Author: Yeh, Chih-Ching|Sung, Fung-Chang|Tang, Reiping|Chang-Chieh, Chung Rong|Hsieh, Ling-Ling
PMID: 17191090
Journal: BMC Med Genet. 2007 May 30;8:28.
Title: Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.
Author: Mahid, Suhal S|Colliver, Daniel W|Crawford, Nigel P S|Martini, Benjamin D|Doll, Mark A|Hein, David W|Cobbs, Gary A|Petras, Robert E|Galandiuk, Susan
PMID: 17537267
Journal: Mutat Res. 2008 Feb 1;638(1-2):162-74. Epub 2007 Oct 13.
Title: Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study.
Author: Butler, Lesley M|Millikan, Robert C|Sinha, Rashmi|Keku, Temitope O|Winkel, Scott|Harlan, Brent|Eaton, Allison|Gammon, Marilie D|Sandler, Robert S
PMID: 18022202
Journal: J Toxicol Environ Health A. 2008;71(13-14):902-5.
Title: N-acetyltransferase 1 in colon and rectal cancer cases from an industrialized area.
Author: Roemer, Hermann C|Weistenhofer, Wobbeke|Lohlein, Dietrich|Geller, Frank|Blomeke, Brunhilde|Golka, Klaus
PMID: 18569593
Journal: Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):2098-106.
Title: Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.
Author: Nothlings, Ute|Yamamoto, Jennifer F|Wilkens, Lynne R|Murphy, Suzanne P|Park, Song-Yi|Henderson, Brian E|Kolonel, Laurence N|Le Marchand, Loic
PMID: 19549810
Journal: Am J Epidemiol. 2010 Nov 1;172(9):1000-14.
Title: Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk.
Author: Cleary, Sean P|Cotterchio, Michelle|Shi, Ellen|Gallinger, Steven|Harper, Patricia
PMID: 20937634
Journal: Mol Biol Rep. 2012 Jul;39(7):7497-503.
Title: The association of NAT1 polymorphisms and colorectal carcinoma risk: evidence from 20,000 subjects.
Author: Cai, Jie|Zhao, Yang|Zhu, Chang Le|Li, Jun|Huang, Zu Hu
PMID: 22327651
Journal: PLoS One. 2012;7(8):e42797.
Title: N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies.
Author: Liu, Jinxin|Ding, Dapeng|Wang, Xiaoxue|Chen, Yizhi|Li, Rong|Zhang, Ying|Luo, Rongcheng
PMID: 22905173
Journal: Int J Mol Epidemiol Genet. 2012;3(2):96-106. Epub 2012 May 15.
Title: Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk.
Author: Eichholzer, Monika|Rohrmann, Sabine|Barbir, Aline|Hermann, Silke|Teucher, Birgit|Kaaks, Rudolf|Linseisen, Jakob
PMID: 22724046
Journal: Carcinogenesis. 2012 Jul;33(7):1332-9.
Title: Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer.
Author: Gilsing, Anne M J|Berndt, Sonja I|Ruder, Elizabeth H|Graubard, Barry I|Ferrucci, Leah M|Burdett, Laura|Weissfeld, Joel L|Cross, Amanda J|Sinha, Rashmi
PMID: 22552404
Journal: Aliment Pharmacol Ther. 2013 Feb;37(4):383-91.
Title: Systematic review: diet-gene interactions and the risk of colorectal cancer.
Author: Andersen, V|Holst, R|Vogel, U
PMID: 23216531
Journal: J Pathol. 2014 Dec;234(4):488-501.
Title: Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma.
Author: Li, Lihua|Sarver, Aaron L|Khatri, Rohini|Hajeri, Praveensingh B|Kamenev, Iris|French, Amy J|Thibodeau, Stephen N|Steer, Clifford J|Subramanian, Subbaya
PMID: 25269767
Journal: Genes Nutr. 2015 Jan;10(1):448.
Title: Interactions between meat intake and genetic variation in relation to colorectal cancer.
Author: Andersen, Vibeke|Vogel, Ulla
PMID: 25491747
Journal: Environ Mol Mutagen. 2015 Aug;56(7):609-20.
Title: Gene-diet interactions in exposure to heterocyclic aromatic amines and bulky DNA adduct levels in blood leukocytes.
Author: Ho, Vikki|Peacock, Sarah|Massey, Thomas E|Godschalk, Roger W L|van Schooten, Frederik J|Chen, Jian|King, Will D
PMID: 26010176
Journal: Int J Mol Med. 2015 Oct;36(4):923-30.
Title: In-depth analysis of the critical genes and pathways in colorectal cancer.
Author: Liu, Fuguo|Ji, Fengzhi|Ji, Yuling|Jiang, Yueping|Sun, Xueguo|Lu, Yanyan|Zhang, Lingyun|Han, Yue|Liu, Xishuang
PMID: 26239303
Journal: Int J Clin Exp Med. 2015 Jun 15;8(6):9177-91. eCollection 2015.
Title: NAT1 polymorphisms and cancer risk: a systematic review and meta-analysis.
Author: Zhang, Kunyi|Gao, Lijuan|Wu, Yuqi|Chen, Jianyi|Lin, Chengguang|Liang, Shaohua|Su, Jianxin|Ye, Jinming|He, Xuyu
PMID: 26309576
Journal: Int J Epidemiol. 2016 Feb;45(1):186-205.
Title: Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.
Author: Montazeri, Zahra|Theodoratou, Evropi|Nyiraneza, Christine|Timofeeva, Maria|Chen, Wanjing|Svinti, Victoria|Sivakumaran, Shanya|Gresham, Gillian|Cubitt, Laura|Carvajal-Carmona, Luis|Bertagnolli, Monica M|Zauber, Ann G|Tomlinson, Ian|Farrington, Susan M|Dunl
PMID: 26451011
Journal: Environ Mol Mutagen. 2018 Jan;59(1):69-78.
Title: Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan.
Author: Kamiza, Abram Bunya|You, Jeng-Fu|Wang, Wen-Chang|Tang, Reiping|Chang, Chun-Yu|Chien, Huei-Tzu|Lai, Chih-Hsiung|Chiu, Li-Ling|Lo, Tsai-Ping|Hung, Kuan-Yi|Hsiung, Chao A|Yeh, Chih-Ching
PMID: 28714190
Journal: PLoS One. 2018 Mar 8;13(3):e0193560.
Title: Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability.
Author: Wang, LiLi|Minchin, Rodney F|Butcher, Neville J
PMID: 29518119
Journal: BMC Genomics. 2018 Jul 3;19(1):513.
Title: Trimodal distribution of arylamine N-acetyltransferase 1 mRNA in breast cancer tumors: association with overall survival and drug resistance.
Author: Minchin, Rodney F|Butcher, Neville J
PMID: 29969986