Primary Site >> Colorectal Cancer
Gene >> NAT1
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Ref: Distribution of acetyltransferase activities in the intestines of rapid and slow acetylator rabbits. PMID: 1860167 |
Ref: Acetyltransferases and susceptibility to chemicals. PMID: 1471166 |
Ref: Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol. PMID: 7902079 |
Ref: Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. PMID: 7585580 Ref: Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. PMID: 7627961 |
Ref: Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility. PMID: 8895986 |
Ref: Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking. PMID: 9107426 Ref: Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases. PMID: 9202744 Ref: The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. PMID: 9202751 |
Ref: N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients. PMID: 9528834 Ref: Expression of arylamine N-acetyltransferase in human intestine. PMID: 9577349 Ref: A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. PMID: 9699660 Ref: Detection of mutations and polymorphism of N-acetyltransferase 1 gene in Indian, Malay and Chinese populations. PMID: 9731716 Ref: Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer. PMID: 9834266 Ref: Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. PMID: 10026993 |
Ref: Meat, metabolic genotypes and risk for colorectal cancer. PMID: 10443949 Ref: Polymorphic NATs and cancer predisposition. PMID: 10493262 |
Ref: Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. PMID: 10667461 Ref: N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review. PMID: 10791558 |
Ref: Metabolic genotypes and risk for colorectal cancer. PMID: 11422615 Ref: Polymorphisms and colorectal tumor risk. PMID: 11487538 Ref: Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk. PMID: 11751443 |
Ref: Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study. PMID: 12074508 Ref: Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. PMID: 12351146 |
Ref: Family history of colon cancer: what does it mean and how is it useful? PMID: 12568823 Ref: No modifying effect of NAT1, GSTM1, and GSTT1 on the relation between smoking and colorectal cancer risk. PMID: 12869413 Ref: Curcumin decreases the DNA adduct formation, arylamines N-acetyltransferase activity and gene expression in human colon tumor cells (colo 205). PMID: 12929584 Ref: Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes. PMID: 14601045 |
Ref: Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. PMID: 14724163 Ref: Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer. PMID: 15736440 Ref: Molecular epidemiology of colon cancer. PMID: 20396547 |
Ref: Relationship between metabolic enzyme polymorphism and colorectal cancer. PMID: 15637738 Ref: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. PMID: 16006997 Ref: Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2). PMID: 16314733 Ref: [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]. PMID: 16471212 |
Ref: Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility. PMID: 17010218 |
Ref: Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. PMID: 16926176 Ref: Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. PMID: 17191090 Ref: Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma. PMID: 17537267 |
Ref: Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study. PMID: 18022202 Ref: N-acetyltransferase 1 in colon and rectal cancer cases from an industrialized area. PMID: 18569593 |
Ref: Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. PMID: 19549810 |
Ref: Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. PMID: 20937634 |
Ref: The association of NAT1 polymorphisms and colorectal carcinoma risk: evidence from 20,000 subjects. PMID: 22327651 Ref: Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer. PMID: 22552404 Ref: Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk. PMID: 22724046 Ref: N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies. PMID: 22905173 |
Ref: Systematic review: diet-gene interactions and the risk of colorectal cancer. PMID: 23216531 |
Ref: Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma. PMID: 25269767 |
Ref: Interactions between meat intake and genetic variation in relation to colorectal cancer. PMID: 25491747 Ref: Gene-diet interactions in exposure to heterocyclic aromatic amines and bulky DNA adduct levels in blood leukocytes. PMID: 26010176 Ref: In-depth analysis of the critical genes and pathways in colorectal cancer. PMID: 26239303 Ref: NAT1 polymorphisms and cancer risk: a systematic review and meta-analysis. PMID: 26309576 |
Ref: Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas. PMID: 26451011 |
Ref: Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan. PMID: 28714190 Ref: Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability. PMID: 29518119 Ref: Trimodal distribution of arylamine N-acetyltransferase 1 mRNA in breast cancer tumors: association with overall survival and drug resistance. PMID: 29969986 |