Primary Site >> Liver Cancer

Gene >> NANOG

Journal: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2445-50.
Title: Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling.
Author: Tang, Yi|Kitisin, Krit|Jogunoori, Wilma|Li, Cuiling|Deng, Chu-Xia|Mueller, Susette C|Ressom, Habtom W|Rashid, Asif|He, Aiwu Ruth|Mendelson, Jonathan S|Jessup, John M|Shetty, Kirti|Zasloff, Michael|Mishra, Bibhuti|Reddy, E P|Johnson, Lynt|Mishra, Lopa
PMID: 18263735
Journal: BMC Med Genomics. 2008 Oct 10;1:49.
Title: The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.
Author: Regenbrecht, Christian Ra|Jung, Marc|Lehrach, Hans|Adjaye, James
PMID: 18847459
Journal: Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S27-30.
Title: Liver stem cells and tgf-Beta in hepatic carcinogenesis.
Author: Amin, Rupen|Mishra, Lopa
PMID: 19343145
Journal: Oncogene. 2009 Feb 19;28(7):961-72.
Title: The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling.
Author: Lin, L|Amin, R|Gallicano, G I|Glasgow, E|Jogunoori, W|Jessup, J M|Zasloff, M|Marshall, J L|Shetty, K|Johnson, L|Mishra, L|He, A R
PMID: 19137011
Journal: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1548-53.
Title: Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog.
Author: Machida, Keigo|Tsukamoto, Hidekazu|Mkrtchyan, Hasmik|Duan, Lewei|Dynnyk, Alla|Liu, Helene Minyi|Asahina, Kinji|Govindarajan, Sugantha|Ray, Ratna|Ou, Jing-Hsiung James|Seki, Ekihiro|Deshaies, Raymond|Miyake, Kensuke|Lai, Michael M-C
PMID: 19171902
Journal: Carcinogenesis. 2010 Feb;31(2):167-74.
Title: The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor.
Author: Xu, Xiao-Lan|Xing, Bao-Cai|Han, Hai-Bo|Zhao, Wei|Hu, Mei-Hao|Xu, Zuo-Liang|Li, Ji-You|Xie, Yong|Gu, Jun|Wang, Yu|Zhang, Zhi-Qian
PMID: 19897602
Journal: Exp Mol Pathol. 2010 Jun;88(3):331-40.
Title: The identification of stem cells in human liver diseases and hepatocellular carcinoma.
Author: Oliva, Joan|French, Barbara A|Qing, X|French, Samuel W
PMID: 20080086
Journal: Mol Cell Biochem. 2010 Oct;343(1-2):155-62.
Title: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways.
Author: Yuan, FangJun|Zhou, Wenbo|Zou, Can|Zhang, Zhiyun|Hu, Hongsheng|Dai, Zongqing|Zhang, YouShun
PMID: 20549546
Journal: Hepatology. 2011 Apr;53(4):1192-205.
Title: Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells.
Author: Schrader, Jorg|Gordon-Walker, Timothy T|Aucott, Rebecca L|van Deemter, Marielle|Quaas, Alexander|Walsh, Shaun|Benten, Daniel|Forbes, Stuart J|Wells, Rebecca G|Iredale, John P
PMID: 21442631
Journal: Cancer Res. 2011 May 15;71(10):3701-8.
Title: Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?
Author: Arzumanyan, Alla|Friedman, Tiffany|Ng, Irene O L|Clayton, Marcia M|Lian, Zhaorui|Feitelson, Mark A
PMID: 21464043
Journal: Cell Stem Cell. 2011 Jul 8;9(1):50-63.
Title: CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation.
Author: Lee, Terence Kin Wah|Castilho, Antonia|Cheung, Vincent Chi Ho|Tang, Kwan Ho|Ma, Stephanie|Ng, Irene Oi Lin
PMID: 21726833
Journal: BMC Cancer. 2011 Sep 19;11:396.
Title: Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics.
Author: Dang, Hien|Ding, Wei|Emerson, Dow|Rountree, C Bart
PMID: 21929801
Journal: PLoS One. 2011;6(12):e28246.
Title: Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells.
Author: Cheung, Phyllis Fung Yi|Cheng, Christine Kei Chin|Wong, Nicholas Chun Lim|Ho, Jenny Chung Yee|Yip, Chi Wai|Lui, Vincent Chi Hang|Cheung, Annie Nga Yin|Fan, Sheung Tat|Cheung, Siu Tim
PMID: 22194816
Journal: J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:19-22.
Title: Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus.
Author: Machida, Keigo|Chen, Chia-Lin|Liu, Jian-Chang|Kashiwabara, Claudine|Feldman, Douglas|French, Samuel W|Sher, Linda|Hyeongnam, Jeong Joseph|Tsukamoto, Hidekazu
PMID: 22320911
Journal: Ann Surg Oncol. 2012 Sep;19(9):2877-87.
Title: Coexpression of stemness factors Oct4 and Nanog predict liver resection.
Author: Yin, Xin|Li, Yi-Wei|Zhang, Bo-Heng|Ren, Zheng-Gang|Qiu, Shuang-Jian|Yi, Yong|Fan, Jia
PMID: 22461131
Journal: Hepatology. 2012 Sep;56(3):1004-14.
Title: Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma.
Author: Shan, Juanjuan|Shen, Junjie|Liu, Limei|Xia, Feng|Xu, Chuan|Duan, Guangjie|Xu, Yanmin|Ma, Qinghua|Yang, Zhi|Zhang, Qianzhen|Ma, Leina|Liu, Jia|Xu, Senlin|Yan, Xiaochu|Bie, Ping|Cui, Youhong|Bian, Xiu-wu|Qian, Cheng
PMID: 22473773
Journal: Dig Dis Sci. 2012 Sep;57(9):2340-6.
Title: Nanog: a potential biomarker for liver metastasis of colorectal cancer.
Author: Xu, Feng|Dai, Chaoliu|Zhang, Rui|Zhao, Yang|Peng, Songlin|Jia, Changjun
PMID: 22562535
Journal: Biochem Biophys Res Commun. 2012 Jun 8;422(3):429-35.
Title: Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines.
Author: Lirdprapamongkol, Kriengsak|Chiablaem, Khajeelak|Sila-Asna, Monnipha|Surarit, Rudee|Bunyaratvej, Ahnond|Svasti, Jisnuson
PMID: 22580004
Journal: Zhonghua Yi Xue Za Zhi. 2012 Dec 25;92(48):3434-7.
Title: [A new method for purification and identification of hepatocellular carcinoma stem cell of SMMC-7721].
Author: Wang, Yong|Liu, Ya-hui|Jiang, Jian-shuai|Cui, Han-bin
PMID: 23327707
Journal: Cell Cycle. 2013 Jan 15;12(2):353-64.
Title: The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming.
Author: Marzi, Ilaria|Cipolleschi, Maria Grazia|D'Amico, Massimo|Stivarou, Theodora|Rovida, Elisabetta|Vinci, Maria Cristina|Pandolfi, Silvia|Dello Sbarba, Persio|Stecca, Barbara|Olivotto, Massimo
PMID: 23287475
Journal: Gastroenterology. 2013 May;144(5):1031-1041.e10.
Title: Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells.
Author: Liu, Shupeng|Li, Nan|Yu, Xiya|Xiao, Xiao|Cheng, Kai|Hu, Jingjing|Wang, Jiaqi|Zhang, Dandan|Cheng, Shuqun|Liu, Shanrong
PMID: 23376424
Journal: Int J Biochem Cell Biol. 2013 Jun;45(6):1099-108.
Title: NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway.
Author: Sun, Chun|Sun, Lu|Jiang, Kai|Gao, Dong-Mei|Kang, Xiao-Nan|Wang, Cun|Zhang, Shu|Huang, Shan|Qin, Xue|Li, Yan|Liu, Yin-Kun
PMID: 23474366
Journal: BMC Cancer. 2013 Apr 2;13:176.
Title: Characterization of in vivo chemoresistant human hepatocellular carcinoma cells with transendothelial differentiation capacities.
Author: Marfels, Christian|Hoehn, Miriam|Wagner, Ernst|Gunther, Michael
PMID: 23547746
Journal: Oncol Lett. 2013 Apr;5(4):1155-1162.
Title: The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma.
Author: Yin, Xin|Li, Yi-Wei|Jin, Jian-Jun|Zhou, Yin|Ren, Zheng-Gang|Qiu, Shuang-Jian|Zhang, Bo-Heng
PMID: 23599755
Journal: J Clin Invest. 2013 Jul;123(7):2832-49.
Title: Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
Author: Chen, Chia-Lin|Tsukamoto, Hidekazu|Liu, Jian-Chang|Kashiwabara, Claudine|Feldman, Douglas|Sher, Linda|Dooley, Steven|French, Samuel W|Mishra, Lopa|Petrovic, Lydia|Jeong, Joseph H|Machida, Keigo
PMID: 23921128
Journal: PLoS One. 2013 Sep 4;8(9):e72435.
Title: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines.
Author: Wang, Xiao Qi|Ng, Ray Kit|Ming, Xiaoyan|Zhang, Wu|Chen, Lin|Chu, Andrew C Y|Pang, Roberta|Lo, Chung Mau|Tsao, Sai Wah|Liu, Xuqing|Poon, Ronnie T P|Fan, Sheung Tat
PMID: 24023739
Journal: PLoS One. 2013 Nov 14;8(11):e80053.
Title: Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma.
Author: Cheng, Shu-Wen|Tsai, Hung-Wen|Lin, Yih-Jyh|Cheng, Pin-Nan|Chang, Yu-Chung|Yen, Chia-Jui|Huang, Hsuan-Pang|Chuang, Yun-Pei|Chang, Ting-Tsung|Lee, Chung-Ta|Chao, Anning|Chou, Cheng-Yang|Chan, Shih-Huang|Chow, Nan-Haw|Ho, Chung-Liang
PMID: 24244607
Journal: World J Gastroenterol. 2013 Dec 21;19(47):8850-60.
Title: Cellular reprogramming and hepatocellular carcinoma development.
Author: Zheng, Yun-Wen|Nie, Yun-Zhong|Taniguchi, Hideki
PMID: 24379607
Journal: Drug Deliv Transl Res. 2013 Apr;3(2):152-64.
Title: Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus.
Author: Machida, Keigo
PMID: 25787983
Journal: Carcinogenesis. 2014 Mar;35(3):537-45.
Title: Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24.
Author: Liu, Allan Yi|Cai, Yao|Mao, Yubin|Lin, Yancheng|Zheng, Hong|Wu, Tiantian|Huang, Yangmei|Fang, Xiaoguang|Lin, Shuyong|Feng, Qingzhao|Huang, Zhengjie|Yang, Tianci|Luo, Qi|Ouyang, Gaoliang
PMID: 24193512
Journal: FEBS Lett. 2014 Feb 14;588(4):566-73.
Title: Hepatitis C virus core protein regulates NANOG expression via the stat3 pathway.
Author: Zhou, Jia-Jia|Chen, Ru-Fu|Deng, Xiao-Geng|Zhou, Yu|Ye, Xiao|Yu, Min|Tang, Jing|He, Xiao-Yu|Cheng, Di|Zeng, Bing|Zhou, Quan-bo|Li, Zhi-hua
PMID: 24462277
Journal: Asian Pac J Trop Med. 2014 Apr;7(4):253-6.
Title: Establishment and identification of induced pluripotent stem cells in liver cancer patients.
Author: Zhang, Da-Ming|Li, Jian-Jun|Yan, Peng|Hu, Jian-Ting
PMID: 24507670
Journal: Int J Cancer. 2014 Oct 15;135(8):1790-9.
Title: Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma.
Author: Lai, Keng Po|Chen, Jiawei|He, Mian|Ching, Arthur K K|Lau, Coleen|Lai, Paul B S|To, Ka-Fai|Wong, Nathalie
PMID: 24585547
Journal: Int J Oncol. 2014 Jun;44(6):2034-40.
Title: Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression.
Author: Zhou, Jia-Jia|Deng, Xiao-Geng|He, Xiao-Yu|Zhou, Yu|Yu, Min|Gao, Wen-Chao|Zeng, Bing|Zhou, Quan-Bo|Li, Zhi-Hua|Chen, Ru-Fu
PMID: 24647772
Journal: World J Gastroenterol. 2014 Jun 14;20(22):6974-80.
Title: Influence of adriamycin on changes in Nanog, Oct-4, Sox2, ARID1 and Wnt5b expression in liver cancer stem cells.
Author: Sun, Ding|Qin, Lei|Xu, Yang|Liu, Jian-Xia|Tian, Li-Ping|Qian, Hai-Xin
PMID: 24944491
Journal: Cancer Res. 2014 Oct 15;74(20):5903-13.
Title: MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.
Author: Akita, Hirofumi|Marquardt, Jens U|Durkin, Marian E|Kitade, Mitsuteru|Seo, Daekwan|Conner, Elizabeth A|Andersen, Jesper B|Factor, Valentina M|Thorgeirsson, Snorri S
PMID: 25189530
Journal: Exp Mol Pathol. 2014 Dec;97(3):399-410.
Title: Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections.
Author: Buzzanco, A|Gomez, A|Rodriguez, E|French, B A|Tillman, B A|Chang, S|Ganapathy, E|Junrungsee, S|Zarrinpar, A|Agopian, V G|Naini, B V|French, S W Jr|French, S W Sr
PMID: 25218810
Journal: BMC Cancer. 2014 Sep 27;14:722.
Title: Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs.
Author: Hashimoto, Noriaki|Tsunedomi, Ryouichi|Yoshimura, Kiyoshi|Watanabe, Yusaku|Hazama, Shoichi|Oka, Masaaki
PMID: 25260650
Journal: PLoS One. 2014 Dec 11;9(12):e114912.
Title: A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma.
Author: Marchio, Agnes|Bertani, Stephane|Rojas Rojas, Teresa|Doimi, Franco|Terris, Benoit|Deharo, Eric|Dejean, Anne|Ruiz, Eloy|Pineau, Pascal
PMID: 25502816
Journal: Hepatol Int. 2014 Sep;8 Suppl 2:408-12.
Title: Alcohol, TLR4-TGF-beta antagonism, and liver cancer.
Author: Tsukamoto, Hidekazu|Mishra, Lopa|Machida, Keigo
PMID: 26201318
Journal: Hepatol Int. 2014 Jul;8(3):330-8.
Title: Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.
Author: Chen, Chia-Lin|Tsukamoto, Hidekazu|Machida, Keigo
PMID: 26202636
Journal: Oncol Rep. 2015 Jan;33(1):149-56.
Title: Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression.
Author: Zhao, Xiulan|Sun, Baocun|Sun, Dan|Liu, Tieju|Che, Na|Gu, Qiang|Dong, Xueyi|Li, Rui|Liu, Yanrong|Li, Jing
PMID: 25339068
Journal: Adv Exp Med Biol. 2015;815:131-44.
Title: TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis.
Author: Machida, Keigo|Feldman, Douglas E|Tsukamoto, Hidekazu
PMID: 25427905
Journal: Cancer Sci. 2015 Feb;106(2):151-9.
Title: TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma.
Author: Xiao, Heng|Jiang, Ning|Zhou, Baoyong|Liu, Qiang|Du, Chengyou
PMID: 25495189
Journal: Clin Cancer Res. 2015 Jan 1;21(1):201-10.
Title: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression.
Author: Chang, Te-Sheng|Wu, Yu-Chih|Chi, Ching-Chi|Su, Wei-Chi|Chang, Pey-Jium|Lee, Kam-Fai|Tung, Tao-Hsin|Wang, Jui|Liu, Jun-Jen|Tung, Shui-Yi|Kuo, Liang-Mou|Ho, Hong-Nerng|Ling, Thai-Yen|Huang, Yen-Hua
PMID: 25564572
Journal: Oncotarget. 2015 Feb 28;6(6):3669-79.
Title: Notch3 functions as a regulator of cell self-renewal by interacting with the beta-catenin pathway in hepatocellular carcinoma.
Author: Zhang, Qingyu|Lu, Caijie|Fang, Tao|Wang, Yongcun|Hu, Wenhua|Qiao, Jie|Liu, Bin|Liu, Jie|Chen, Nianping|Li, Mingyi|Zhu, Runzhi
PMID: 25668819
Journal: Oncol Rep. 2015 Apr;33(4):1965-75.
Title: OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: a bioinformatic analysis combine with RNAi and oligonucleotide microarray.
Author: Hu, Qiping|Fu, Jun|Luo, Bin|Huang, Miao|Guo, Wenwen|Lin, Yongda|Xie, Xiaoxun|Xiao, Shaowen
PMID: 25673160
Journal: J Hematol Oncol. 2015 Mar 11;8:23.
Title: Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling.
Author: Yin, Xin|Zhang, Bo-Heng|Zheng, Su-Su|Gao, Dong-Mei|Qiu, Shuang-Jian|Wu, Wei-Zhong|Ren, Zheng-Gang
PMID: 25879771
Journal: Gastroenterology. 2015 Oct;149(4):1068-81.e5.
Title: Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.
Author: Song, Yangyang|Pan, Guangjin|Chen, Leilei|Ma, Stephanie|Zeng, Tingting|Man Chan, Tim Hon|Li, Lei|Lian, Qizhou|Chow, Raymond|Cai, Xiujuan|Li, Yan|Li, Yan|Liu, Ming|Li, Yun|Zhu, Yinghui|Wong, Nathalie|Yuan, Yun-Fei|Pei, Duanqing|Guan, Xin-Yuan
PMID: 26099525
Journal: Hepatology. 2015 Nov;62(5):1466-79.
Title: NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.
Author: Siddique, Hifzur R|Feldman, Douglas E|Chen, Chia-Lin|Punj, Vasu|Tokumitsu, Hiroshi|Machida, Keigo
PMID: 26174965
Journal: Oncotarget. 2015 Sep 15;6(27):24163-77.
Title: TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma.
Author: Zhou, Dong-Sheng|Wang, Hong-Bo|Zhou, Zhong-Guo|Zhang, Yao-Jun|Zhong, Qian|Xu, Li|Huang, Yue-Hua|Yeung, Sai-Ching|Chen, Min-Shan|Zeng, Mu-Sheng
PMID: 26219398
Journal: Oncotarget. 2015 Nov 10;6(35):37200-15.
Title: Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism.
Author: Sureban, Sripathi M|Madhoun, Mohammad F|May, Randal|Qu, Dongfeng|Ali, Naushad|Fazili, Javid|Weygant, Nathaniel|Chandrakesan, Parthasarathy|Ding, Kai|Lightfoot, Stanley A|Houchen, Courtney W
PMID: 26468984
Journal: Oncotarget. 2015 Dec 29;6(42):44452-65.
Title: Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.
Author: Han, Shuo|Guo, Jinhai|Liu, Yinan|Zhang, Zhi|He, Qihua|Li, Peng|Zhang, Mingzhi|Sun, Haojie|Li, Ruizhi|Li, Yang|Zeng, Wotan|Liu, Jinwen|Lian, Lejian|Gao, Yi|Shen, Li
PMID: 26540347
Journal: Gastroenterology. 2016 Mar;150(3):707-19.
Title: TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.
Author: Uthaya Kumar, Dinesh Babu|Chen, Chia-Lin|Liu, Jian-Chang|Feldman, Douglas E|Sher, Linda S|French, Samuel|DiNorcia, Joseph|French, Samuel W|Naini, Bita V|Junrungsee, Sunhawit|Agopian, Vatche Garen|Zarrinpar, Ali|Machida, Keigo
PMID: 26582088
Journal: Clin Cancer Res. 2016 Apr 15;22(8):2041-50.
Title: ICAM-1-Related Noncoding RNA in Cancer Stem Cells Maintains ICAM-1 Expression in Hepatocellular Carcinoma.
Author: Guo, Weixing|Liu, Shupeng|Cheng, Yuqiang|Lu, Lei|Shi, Jie|Xu, Guixia|Li, Nan|Cheng, Kai|Wu, Mengchao|Cheng, Shuqun|Liu, Shanrong
PMID: 26667486
Journal: Oncol Rep. 2016 Mar;35(3):1657-63.
Title: TALEN-induced disruption of Nanog expression results in reduced proliferation, invasiveness and migration, increased chemosensitivity and reversal of EMT in HepG2 cells.
Author: Yu, Ai Qing|Ding, Yan|Li, Cheng Lin|Yang, Yi|Yan, Shi Rong|Li, Dong Sheng
PMID: 26676719
Journal: Cell Metab. 2016 Jan 12;23(1):206-19.
Title: NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.
Author: Chen, Chia-Lin|Uthaya Kumar, Dinesh Babu|Punj, Vasu|Xu, Jun|Sher, Linda|Tahara, Stanley M|Hess, Sonja|Machida, Keigo
PMID: 26724859
Journal: J Transl Med. 2016 Feb 12;14:49.
Title: Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells.
Author: Gehlot, Prashasnika|Shukla, Vivek|Gupta, Sanjay|Makidon, Paul E
PMID: 26873175
Journal: Tumour Biol. 2016 Aug;37(8):10943-58.
Title: Combination of 5-fluorouracil and 2-morphilino-8-phenyl-4H-chromen-4-one may inhibit liver cancer stem cell activity.
Author: Peng, Yu-Chong|Lu, Shi-Dong|Zhong, Jian-Hong|Xie, Zhi-Bo|You, Xue-Mei|Peng, Ning-Fu|Li, Le-Qun
PMID: 26886287
Journal: Sci Rep. 2016 Feb 18;6:21340.
Title: Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1alpha activation.
Author: Ambade, Aditya|Satishchandran, Abhishek|Szabo, Gyongyi
PMID: 26888602
Journal: PLoS One. 2016 Feb 26;11(2):e0149897.
Title: Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma.
Author: Chang, Te-Sheng|Chen, Chi-Long|Wu, Yu-Chih|Liu, Jun-Jen|Kuo, Yung Che|Lee, Kam-Fai|Lin, Sin-Yi|Lin, Sey-En|Tung, Shui-Yi|Kuo, Liang-Mou|Tsai, Ying-Huang|Huang, Yen-Hua
PMID: 26919045
Journal: Tumour Biol. 2016 Aug;37(8):11199-208.
Title: Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells independently of AMPK.
Author: Shen, Chen|Ka, Sun-O|Kim, Su Jin|Kim, Ji Hye|Park, Byung-Hyun|Park, Ji Hyun
PMID: 26939902
Journal: Oncotarget. 2016 Apr 19;7(16):21644-57.
Title: Hepatic cancer stem cell marker granulin-epithelin precursor and beta-catenin expression associate with recurrence in hepatocellular carcinoma.
Author: Cheung, Phyllis F Y|Cheung, Tan To|Yip, Chi Wai|Ng, Linda W C|Fung, Sze Wai|Lo, Chung Mau|Fan, Sheung Tat|Cheung, Siu Tim
PMID: 26942873
Journal: Cancer Lett. 2016 Jun 1;375(2):390-399.
Title: Non-CSCs nourish CSCs through interleukin-17E-mediated activation of NF-kappaB and JAK/STAT3 signaling in human hepatocellular carcinoma.
Author: Luo, Yongli|Yang, Zhi|Su, Li|Shan, Juanjuan|Xu, Huailong|Xu, Yanmin|Liu, Limei|Zhu, Wei|Chen, Xuejiao|Liu, Chungang|Chen, Jun|Yao, Chao|Cheng, Feifei|Zhang, Chengcheng|Ma, Qinghua|Shen, Junjie|Qian, Cheng
PMID: 27000993
Journal: Oncotarget. 2016 May 31;7(22):32221-31.
Title: Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells.
Author: You, Yang|Zheng, Qiongdan|Dong, Yinying|Xie, Xiaoying|Wang, Yaohui|Wu, Sifan|Zhang, Lan|Wang, Yingcong|Xue, Tongchun|Wang, Zhiming|Chen, Rongxin|Wang, Yanhong|Cui, Jiefeng|Ren, Zhenggang
PMID: 27050147
Journal: Oncoimmunology. 2015 Aug 31;5(3):e1086060.
Title: Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition.
Author: Rong, Xiao-Xiang|Wei, Fang|Lin, Xiao-Lin|Qin, Yu-Juan|Chen, Lin|Wang, Hui-Yan|Shen, Hong-Fen|Jia, Li-Ting|Xie, Rao-Ying|Lin, Tao-Yan|Hao, Wei-Chao|Yang, Jie|Yang, Sheng|Cheng, Yu-Shuang|Huang, Wen-Hua|Li, Ai-Min|Sun, Yan|Luo, Rong-Cheng|Xiao, Dong
PMID: 27141341
Journal: Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G91-G104.
Title: Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling.
Author: Sun, Lina|Beggs, Kevin|Borude, Prachi|Edwards, Genea|Bhushan, Bharat|Walesky, Chad|Roy, Nairita|Manley, Michael W Jr|Gunewardena, Sumedha|O'Neil, Maura|Li, Hua|Apte, Udayan
PMID: 27151938
Journal: Oncotarget. 2016 Jun 14;7(24):36814-36828.
Title: Androgen/androgen receptor axis maintains and promotes cancer cell stemness through direct activation of Nanog transcription in hepatocellular carcinoma.
Author: Jiang, Lupin|Shan, Juanjuan|Shen, Junjie|Wang, Yanzhou|Yan, Ping|Liu, Limei|Zhao, Wenxu|Xu, Yanmin|Zhu, Wei|Su, Li|Chen, Jun|Cheng, Feifei|Yao, Hong|Xu, Huicheng|Qian, Cheng|Liang, Zhiqing
PMID: 27167111
Journal: J Hepatol. 2016 Nov;65(5):888-898.
Title: EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes.
Author: Mani, Saravana Kumar Kailasam|Zhang, Hao|Diab, Ahmed|Pascuzzi, Pete E|Lefrancois, Lydie|Fares, Nadim|Bancel, Brigitte|Merle, Philippe|Andrisani, Ourania
PMID: 27238755
Journal: Oncotarget. 2016 Aug 2;7(31):49194-49216.
Title: Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.
Author: Simile, Maria M|Latte, Gavinella|Demartis, Maria I|Brozzetti, Stefania|Calvisi, Diego F|Porcu, Alberto|Feo, Claudio F|Seddaiu, Maria A|Daino, Lucia|Berasain, Carmen|Tomasi, Maria L|Avila, Matias A|Feo, Francesco|Pascale, Rosa M
PMID: 27359056
Journal: Med Sci Monit. 2016 Aug 27;22:3025-34.
Title: Effect of Over-Expression of Zinc-Finger Protein (ZFX) on Self-Renewal and Drug-Resistance of Hepatocellular Carcinoma.
Author: Zhang, Shuhong|Shu, Ronghua|Yue, Meng|Zhang, Shuhong
PMID: 27566731
Journal: Mol Med. 2016 Oct;22:653-663.
Title: Stemness-related transcriptional factors and homing gene expression profiles in hepatic differentiation and cancer.
Author: Toraih, Eman A|Fawzy, Manal S|El-Falouji, Abdullah I|Hamed, Elham O|Nemr, Nader A|Hussein, Mohammad H|Abd El Fadeal, Noha M
PMID: 27623812
Journal: Cancer Res. 2016 Dec 1;76(23):7059-7071.
Title: NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling.
Author: Zhang, Lixing|Ge, Chao|Zhao, Fangyu|Zhang, Yang|Wang, Xin|Yao, Ming|Li, Jinjun
PMID: 27634758
Journal: J Exp Clin Cancer Res. 2016 Nov 11;35(1):176.
Title: miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma.
Author: Zhang, Xi|Jiang, Peng|Shuai, Ling|Chen, Kai|Li, Zhonghu|Zhang, Yujun|Jiang, Yan|Li, Xiaowu
PMID: 27835990
Journal: Cell Physiol Biochem. 2016;40(1-2):219-229.
Title: The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers.
Author: Pan, Yan|Li, Chen|Chen, Jing|Zhang, Kai|Chu, Xiaoyuan|Wang, Rui|Chen, Longbang
PMID: 27855392
Journal: Clin Cancer Res. 2016 Dec 15;22(24):6303.
Title: Correction: Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG Expression.
Author:
PMID: 27980027
Journal: Sci Rep. 2017 Jan 13;7:40464.
Title: Integrin beta4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma.
Author: Li, Xiao-Long|Liu, Lin|Li, Dan-Dan|He, Ya-Ping|Guo, Le-Hang|Sun, Li-Ping|Liu, Lin-Na|Xu, Hui-Xiong|Zhang, Xiao-Ping
PMID: 28084395
Journal: Sci Rep. 2017 Jan 30;7:41499.
Title: CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma.
Author: Liu, Kai|Hao, Meijun|Ouyang, Yabo|Zheng, Jiasheng|Chen, Dexi
PMID: 28134312
Journal: Cell Death Discov. 2017 Jan 23;3:16105.
Title: Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer.
Author: Wang, Pan|Wan, Wen-Wu|Xiong, Shuang-Long|Feng, Hua|Wu, Nan
PMID: 28179999
Journal: Oncotarget. 2017 Apr 4;8(14):23507-23516.
Title: C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway.
Author: Ching, Rachel Hiu Ha|Sze, Karen Man Fong|Lau, Eunice Yuen Ting|Chiu, Yung-Tuen|Lee, Joyce Man Fong|Ng, Irene Oi Lin|Lee, Terence Kin Wah
PMID: 28186991
Journal: Cancer Lett. 2017 Aug 1;400:149-160.
Title: Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells.
Author: Liu, Zhixin|Dai, Xuechen|Wang, Tianci|Zhang, Chengcheng|Zhang, Wenjun|Zhang, Wei|Zhang, Qi|Wu, Kailang|Liu, Fang|Liu, Yingle|Wu, Jianguo
PMID: 28455240
Journal: Life Sci. 2017 Jun 15;179:80-87.
Title: Toll like receptor 4 and hepatocellular carcinoma; A systematic review.
Author: Sepehri, Zahra|Kiani, Zohre|Kohan, Farhad|Alavian, Seyed Moayed|Ghavami, Saeid
PMID: 28472619
Journal: Sci Rep. 2017 May 19;7(1):2164.
Title: Activated hepatic stellate cells secrete periostin to induce stem cell-like phenotype of residual hepatocellular carcinoma cells after heat treatment.
Author: Zhang, Rui|Yao, Rong-Rong|Li, Jing-Huan|Dong, Gang|Ma, Min|Zheng, Qiong-Dan|Gao, Dong-Mei|Cui, Jie-Feng|Ren, Zheng-Gang|Chen, Rong-Xin
PMID: 28526827
Journal: World J Gastroenterol. 2017 May 14;23(18):3252-3261.
Title: Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B.
Author: Wang, Xuyang|Oishi, Naoki|Shimakami, Tetsuro|Yamashita, Taro|Honda, Masao|Murakami, Seishi|Kaneko, Shuichi
PMID: 28566884
Journal: Oncogene. 2017 Oct 12;36(41):5709-5721.
Title: Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
Author: Sengupta, S|Nagalingam, A|Muniraj, N|Bonner, M Y|Mistriotis, P|Afthinos, A|Kuppusamy, P|Lanoue, D|Cho, S|Korangath, P|Shriver, M|Begum, A|Merino, V F|Huang, C-Y|Arbiser, J L|Matsui, W|Gyorffy, B|Konstantopoulos, K|Sukumar, S|Marignani, P A|Saxena, N K|Sha
PMID: 28581518
Journal: J Exp Clin Cancer Res. 2017 Jun 24;36(1):86.
Title: HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition.
Author: Huan, Hong-Bo|Yang, Da-Peng|Wen, Xu-Dong|Chen, Xue-Jiao|Zhang, Liang|Wu, Li-Li|Bie, Ping|Xia, Feng
PMID: 28646927
Journal: Biomed Rep. 2017 Jul;7(1):73-78.
Title: Identification of rhodamine 123-positive stem cell subpopulations in canine hepatocellular carcinoma cells.
Author: Itoh, Harumichi|Nishikawa, Shimpei|Haraguchi, Tomoya|Arikawa, Yu|Hiyama, Masato|Iseri, Toshie|Itoh, Yoshiki|Nakaichi, Munekazu|Taura, Yasuho|Tani, Kenji|Itamoto, Kazuhito
PMID: 28685064
Journal: Oncogenesis. 2017 Jul 24;6(7):e363.
Title: Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma.
Author: Zhang, T|Huang, Y|Liu, W|Meng, W|Zhao, H|Yang, Q|Gu, S-J|Xiao, C-C|Jia, C-C|Zhang, B|Zou, Y|Li, H-P|Fu, B-S
PMID: 28737756
Journal: J Virol. 2017 Oct 13;91(21). pii: JVI.01235-17.
Title: Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis.
Author: Kwon, Young-Chan|Sasaki, Reina|Meyer, Keith|Ray, Ranjit
PMID: 28794048
Journal: Lab Invest. 2017 Oct;97(10):1201-1217.
Title: Activation of pluripotent genes in hepatic progenitor cells in the transition of nonalcoholic steatohepatitis to pre-malignant lesions.
Author: Xu, Gang|Ye, Juan|Liu, Xue-Jing|Zhang, Ning-Ping|Zhao, Yi-Ming|Fan, Jia|Liu, Xiu-Ping|Wu, Jian
PMID: 28869588
Journal: Am J Pathol. 2017 Dec;187(12):2711-2725.
Title: Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.
Author: Yamamoto, Masahiro|Xin, Bing|Watanabe, Kenji|Ooshio, Takako|Fujii, Kiyonaga|Chen, Xi|Okada, Yoko|Abe, Hiroaki|Taguchi, Yoshimitsu|Miyokawa, Naoyuki|Furukawa, Hiroyuki|Nishikawa, Yuji
PMID: 28964793
Journal: Tumour Biol. 2017 Oct;39(10):1010428317719272.
Title: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
Author: Zou, Juan|Li, Hong|Huang, Qianling|Liu, Xiaomin|Qi, Xiaoxiao|Wang, Ying|Lu, Linlin|Liu, Zhongqiu
PMID: 29025375
Journal: Mol Cell. 2017 Oct 19;68(2):281-292.e5.
Title: Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells.
Author: Liu, Kai|Lee, Jiyoung|Kim, Ja Yeon|Wang, Linya|Tian, Yongjun|Chan, Stephanie T|Cho, Cecilia|Machida, Keigo|Chen, Dexi|Ou, Jing-Hsiung James
PMID: 29033320
Journal: Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(20):3990-3995.
Title: [Effects of aqueous extracts of gecko on stemness of hepatocellular carcinoma].
Author: Huang, Hui-Ling|Zhang, Ya-Lan|Chen, Wen-Fa|Wu, Chun-Ling
PMID: 29243438
Journal: Antioxid Redox Signal. 2017 Dec 19.
Title: Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells.
Author: Machida, Keigo
PMID: 29256636
Journal: Oncotarget. 2017 Nov 27;8(66):110187-110200.
Title: MicroRNA-449a maintains self-renewal in liver cancer stem-like cells by targeting Tcf3.
Author: Zhang, Qianzhen|Yang, Zhi|Shan, Juanjuan|Liu, Limei|Liu, Chungang|Shen, Junjie|Chen, Xuejiao|Xu, Yanmin|Chen, Jun|Ma, Qinghua|Yang, Li|Qian, Cheng
PMID: 29299140
Journal: Clin Chim Acta. 2018 Feb;477:24-31.
Title: Prognostic and clinicopathological value of Nanog in hepatocellular carcinoma: A meta-analysis.
Author: Liang, Chaojie|Zhang, Kaitong|Ge, Hua|Li, Wei|Li, Guangming|Wu, Jixiang
PMID: 29198990
Journal: Mol Cell Oncol. 2018 Jan 23;5(2):e1405142.
Title: Autophagy and mitophagy in hepatocarcinogenesis.
Author: Liu, Kai|Lee, Jiyoung|Ou, Jing-Hsiung James
PMID: 29487894
Journal: Oncol Lett. 2018 May;15(5):7783-7793.
Title: Bioinformatic analysis and prediction of the function and regulatory network of long non-coding RNAs in hepatocellular carcinoma.
Author: Cao, Ming-Rong|Han, Ze-Ping|Liu, Ji-Ming|Li, Yu-Guang|Lv, Yu-Bing|Zhou, Jia-Bin|He, Jin-Hua
PMID: 29740493
Journal: Eur J Pharmacol. 2018 Aug 5;832:39-49.
Title: Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT.
Author: Mao, Jie|Yang, Hongbao|Cui, Tingting|Pan, Pan|Kabir, Nadia|Chen, Duo|Ma, Jinyan|Chen, Xingyi|Chen, Yijun|Yang, Yong
PMID: 29782854
Journal: Cancer Biomark. 2018;22(3):575-585.
Title: Effect of Bmi-1-mediated NF-kappaB signaling pathway on the stem-like properties of CD133+ human liver cancer cells.
Author: Ma, De-Qiang|Zhang, Yin-Hua|Ding, De-Ping|Li, Juan|Chen, Lin-Li|Tian, You-You|Ao, Kang-Jian
PMID: 29843222
Journal: Theranostics. 2018 Jun 13;8(14):3737-3750.
Title: Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma.
Author: Wu, Chuan Xing|Wang, Xiao Qi|Chok, Siu Ho|Man, Kwan|Tsang, Simon Hing Yin|Chan, Albert Chi Yan|Ma, Ka Wing|Xia, Wei|Cheung, Tan To
PMID: 30083256
Journal: Oncol Lett. 2018 Oct;16(4):5243-5248.
Title: Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells.
Author: Tomizawa, Minoru|Shinozaki, Fuminobu|Motoyoshi, Yasufumi|Sugiyama, Takao|Yamamoto, Shigenori|Ishige, Naoki
PMID: 30250594
Journal: Int J Biochem Cell Biol. 2018 Oct 9. pii: S1357-2725(18)30213-9.
Title: Corrigendum to "NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway" [Int. J. Biochem. Cell Biol. (2013) 1099-1108].
Author: Sun, Chun|Sun, Lu|Jiang, Kai|Gao, Dong-Mei|Kang, Xiao-Nan|Wang, Cun|Zhang, Shu|Huang, Shan|Qin, Xue|Li, Yan|Liu, Yin-Kun
PMID: 30314944
Journal: Adv Exp Med Biol. 2018;1032:105-113.
Title: NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells.
Author: Machida, Keigo
PMID: 30362094