Primary Site >> Liver Cancer
Gene >> NANOG
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Ref: Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. PMID: 18263735 Ref: The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. PMID: 18847459 Ref: Liver stem cells and tgf-Beta in hepatic carcinogenesis. PMID: 19343145 |
Ref: The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. PMID: 19137011 Ref: Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. PMID: 19171902 |
Ref: The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor. PMID: 19897602 Ref: The identification of stem cells in human liver diseases and hepatocellular carcinoma. PMID: 20080086 Ref: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways. PMID: 20549546 |
Ref: Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. PMID: 21442631 Ref: Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? PMID: 21464043 Ref: CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. PMID: 21726833 Ref: Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics. PMID: 21929801 Ref: Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells. PMID: 22194816 |
Ref: Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. PMID: 22320911 Ref: Coexpression of stemness factors Oct4 and Nanog predict liver resection. PMID: 22461131 Ref: Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma. PMID: 22473773 Ref: Nanog: a potential biomarker for liver metastasis of colorectal cancer. PMID: 22562535 Ref: Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. PMID: 22580004 Ref: [A new method for purification and identification of hepatocellular carcinoma stem cell of SMMC-7721]. PMID: 23327707 |
Ref: The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming. PMID: 23287475 Ref: Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells. PMID: 23376424 Ref: NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway. PMID: 23474366 Ref: Characterization of in vivo chemoresistant human hepatocellular carcinoma cells with transendothelial differentiation capacities. PMID: 23547746 Ref: The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. PMID: 23599755 Ref: Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells. PMID: 23921128 Ref: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines. PMID: 24023739 Ref: Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. PMID: 24244607 Ref: Cellular reprogramming and hepatocellular carcinoma development. PMID: 24379607 Ref: Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus. PMID: 25787983 |
Ref: Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24. PMID: 24193512 Ref: Hepatitis C virus core protein regulates NANOG expression via the stat3 pathway. PMID: 24462277 Ref: Establishment and identification of induced pluripotent stem cells in liver cancer patients. PMID: 24507670 Ref: Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma. PMID: 24585547 Ref: Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression. PMID: 24647772 Ref: Influence of adriamycin on changes in Nanog, Oct-4, Sox2, ARID1 and Wnt5b expression in liver cancer stem cells. PMID: 24944491 Ref: MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism. PMID: 25189530 Ref: Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections. PMID: 25218810 Ref: Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs. PMID: 25260650 Ref: A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma. PMID: 25502816 Ref: Alcohol, TLR4-TGF-beta antagonism, and liver cancer. PMID: 26201318 Ref: Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. PMID: 26202636 |
Ref: Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression. PMID: 25339068 Ref: TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. PMID: 25427905 Ref: TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma. PMID: 25495189 Ref: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. PMID: 25564572 Ref: Notch3 functions as a regulator of cell self-renewal by interacting with the beta-catenin pathway in hepatocellular carcinoma. PMID: 25668819 Ref: OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: a bioinformatic analysis combine with RNAi and oligonucleotide microarray. PMID: 25673160 Ref: Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling. PMID: 25879771 Ref: Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells. PMID: 26099525 Ref: NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer. PMID: 26174965 Ref: TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma. PMID: 26219398 Ref: Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism. PMID: 26468984 Ref: Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation. PMID: 26540347 |
Ref: TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. PMID: 26582088 Ref: ICAM-1-Related Noncoding RNA in Cancer Stem Cells Maintains ICAM-1 Expression in Hepatocellular Carcinoma. PMID: 26667486 Ref: TALEN-induced disruption of Nanog expression results in reduced proliferation, invasiveness and migration, increased chemosensitivity and reversal of EMT in HepG2 cells. PMID: 26676719 Ref: NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism. PMID: 26724859 Ref: Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells. PMID: 26873175 Ref: Combination of 5-fluorouracil and 2-morphilino-8-phenyl-4H-chromen-4-one may inhibit liver cancer stem cell activity. PMID: 26886287 Ref: Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1alpha activation. PMID: 26888602 Ref: Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma. PMID: 26919045 Ref: Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells independently of AMPK. PMID: 26939902 Ref: Hepatic cancer stem cell marker granulin-epithelin precursor and beta-catenin expression associate with recurrence in hepatocellular carcinoma. PMID: 26942873 Ref: Non-CSCs nourish CSCs through interleukin-17E-mediated activation of NF-kappaB and JAK/STAT3 signaling in human hepatocellular carcinoma. PMID: 27000993 Ref: Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells. PMID: 27050147 Ref: Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition. PMID: 27141341 Ref: Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. PMID: 27151938 Ref: Androgen/androgen receptor axis maintains and promotes cancer cell stemness through direct activation of Nanog transcription in hepatocellular carcinoma. PMID: 27167111 Ref: EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. PMID: 27238755 Ref: Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease. PMID: 27359056 Ref: Effect of Over-Expression of Zinc-Finger Protein (ZFX) on Self-Renewal and Drug-Resistance of Hepatocellular Carcinoma. PMID: 27566731 Ref: Stemness-related transcriptional factors and homing gene expression profiles in hepatic differentiation and cancer. PMID: 27623812 Ref: NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling. PMID: 27634758 Ref: miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma. PMID: 27835990 Ref: The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers. PMID: 27855392 Ref: Correction: Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG Expression. PMID: 27980027 |
Ref: Integrin beta4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma. PMID: 28084395 Ref: CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma. PMID: 28134312 Ref: Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer. PMID: 28179999 Ref: C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway. PMID: 28186991 Ref: Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. PMID: 28455240 Ref: Toll like receptor 4 and hepatocellular carcinoma; A systematic review. PMID: 28472619 Ref: Activated hepatic stellate cells secrete periostin to induce stem cell-like phenotype of residual hepatocellular carcinoma cells after heat treatment. PMID: 28526827 Ref: Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. PMID: 28566884 Ref: Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. PMID: 28581518 Ref: HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition. PMID: 28646927 Ref: Identification of rhodamine 123-positive stem cell subpopulations in canine hepatocellular carcinoma cells. PMID: 28685064 Ref: Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma. PMID: 28737756 Ref: Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis. PMID: 28794048 Ref: Activation of pluripotent genes in hepatic progenitor cells in the transition of nonalcoholic steatohepatitis to pre-malignant lesions. PMID: 28869588 Ref: Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors. PMID: 28964793 Ref: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma. PMID: 29025375 Ref: Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells. PMID: 29033320 Ref: [Effects of aqueous extracts of gecko on stemness of hepatocellular carcinoma]. PMID: 29243438 Ref: Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells. PMID: 29256636 Ref: MicroRNA-449a maintains self-renewal in liver cancer stem-like cells by targeting Tcf3. PMID: 29299140 |
Ref: Prognostic and clinicopathological value of Nanog in hepatocellular carcinoma: A meta-analysis. PMID: 29198990 Ref: Autophagy and mitophagy in hepatocarcinogenesis. PMID: 29487894 Ref: Bioinformatic analysis and prediction of the function and regulatory network of long non-coding RNAs in hepatocellular carcinoma. PMID: 29740493 Ref: Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT. PMID: 29782854 Ref: Effect of Bmi-1-mediated NF-kappaB signaling pathway on the stem-like properties of CD133+ human liver cancer cells. PMID: 29843222 Ref: Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma. PMID: 30083256 Ref: Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells. PMID: 30250594 Ref: Corrigendum to "NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway" [Int. J. Biochem. Cell Biol. (2013) 1099-1108]. PMID: 30314944 Ref: NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells. PMID: 30362094 |