Primary Site >> Colorectal Cancer

Gene >> MYD88

Journal: BMC Cancer. 2006 Dec 8;6:281.
Title: Intracellular expression of toll-like receptor 4 in neuroblastoma cells and their unresponsiveness to lipopolysaccharide.
Author: Hassan, Ferdaus|Islam, Shamima|Tumurkhuu, Gantsetseg|Naiki, Yoshikazu|Koide, Naoki|Mori, Isamu|Yoshida, Tomoaki|Yokochi, Takashi
PMID: 17156435
Journal: Gastroenterology. 2008 Aug;135(2):518-28.
Title: Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer.
Author: Rhee, Sang Hoon|Im, Eunok|Pothoulakis, Charalabos
PMID: 18538140
Journal: PLoS One. 2009 Jun 24;4(6):e6026.
Title: Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
Author: Uronis, Joshua M|Muhlbauer, Marcus|Herfarth, Hans H|Rubinas, Tara C|Jones, Gieira S|Jobin, Christian
PMID: 19551144
Journal: J Surg Oncol. 2009 Dec 15;100(8):725-31.
Title: Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway.
Author: Ikebe, Mio|Kitaura, Yoshiki|Nakamura, Masafumi|Tanaka, Haruo|Yamasaki, Akio|Nagai, Shuntaro|Wada, Junji|Yanai, Kosuke|Koga, Kenichiro|Sato, Norihiro|Kubo, Makoto|Tanaka, Masao|Onishi, Hideya|Katano, Mitsuo
PMID: 19722233
Journal: Cancer Cell. 2009 Sep 8;16(3):208-19.
Title: Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells.
Author: Garrett, Wendy S|Punit, Shivesh|Gallini, Carey A|Michaud, Monia|Zhang, Dorothy|Sigrist, Kirsten S|Lord, Graham M|Glickman, Jonathan N|Glimcher, Laurie H
PMID: 19732721
Journal: Br J Cancer. 2010 Mar 2;102(5):908-15.
Title: High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.
Author: Wang, E L|Qian, Z R|Nakasono, M|Tanahashi, T|Yoshimoto, K|Bando, Y|Kudo, E|Shimada, M|Sano, T
PMID: 20145615
Journal: Mol Cancer Ther. 2010 Jun;9(6):1788-97.
Title: Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8.
Author: Wang, Daqing|Precopio, Melissa|Lan, Tao|Yu, Dong|Tang, Jimmy X|Kandimalla, Ekambar R|Agrawal, Sudhir
PMID: 20515950
Journal: EMBO J. 2010 Jul 7;29(13):2242-52.
Title: TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.
Author: Mittal, Deepak|Saccheri, Fabiana|Venereau, Emilie|Pusterla, Tobias|Bianchi, Marco E|Rescigno, Maria
PMID: 20526283
Journal: Cancer Res. 2010 Sep 15;70(18):7209-20.
Title: Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity.
Author: Hartman, Zachary C|Osada, Takuya|Glass, Oliver|Yang, Xiao Y|Lei, Gang-Jun|Lyerly, H Kim|Clay, Timothy M
PMID: 20823152
Journal: PLoS One. 2012;7(1):e29357.
Title: TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome.
Author: Saha, Subhrajit|Bhanja, Payel|Liu, Laibin|Alfieri, Alan A|Yu, Dong|Kandimalla, Ekambar R|Agrawal, Sudhir|Guha, Chandan
PMID: 22238604
Journal: Tumori. 2012 Sep-Oct;98(5):663-9.
Title: Mutational and expressional analyses of MYD88 gene in common solid cancers.
Author: Je, Eun Mi|Kim, Sung Soo|Yoo, Nam Jin|Lee, Sug Hyung
PMID: 23235763
Journal: J Gastroenterol. 2012 Feb;47(2):97-106.
Title: The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models.
Author: Oshima, Hiroko|Oshima, Masanobu
PMID: 22218775
Journal: Int J Cancer. 2013 Jun 15;132(12):2839-48.
Title: Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells.
Author: Hong, Eun-Hye|Chang, Sun-Young|Lee, Bo-Ra|Kim, Yun-Sun|Lee, Jeong-Mi|Kang, Chang-Yuil|Kweon, Mi-Na|Ko, Hyun-Jeong
PMID: 23184679
Journal: J Natl Cancer Inst. 2013 Jul 3;105(13):937-46.
Title: MyD88 in DNA repair and cancer cell resistance to genotoxic drugs.
Author: Kfoury, Alain|Le Corf, Katy|El Sabeh, Rana|Journeaux, Alexandra|Badran, Bassam|Hussein, Nader|Lebecque, Serge|Manie, Serge|Renno, Toufic|Coste, Isabelle
PMID: 23766530
Journal: J Natl Cancer Inst. 2013 Jul 3;105(13):926-7.
Title: Repressing DNA repair to enhance chemotherapy: targeting MyD88 in colon cancer.
Author: Williamson, Elizabeth A|Hromas, Robert
PMID: 23766531
Journal: Carcinogenesis. 2013 Nov;34(11):2512-20.
Title: Innate immunity gene polymorphisms and the risk of colorectal neoplasia.
Author: Chang, Cindy M|Chia, Victoria M|Gunter, Marc J|Zanetti, Krista A|Ryan, Brid M|Goodman, Julie E|Harris, Curtis C|Weissfeld, Joel|Huang, Wen-Yi|Chanock, Stephen|Yeager, Meredith|Hayes, Richard B|Berndt, Sonja I
PMID: 23803696
Journal: Cancer Res. 2013 Dec 15;73(24):7211-21.
Title: TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy.
Author: Gao, Chan|Kozlowska, Anna|Nechaev, Sergey|Li, Haiqing|Zhang, Qifang|Hossain, Dewan M S|Kowolik, Claudia M|Chu, Peiguo|Swiderski, Piotr|Diamond, Don J|Pal, Sumanta K|Raubitschek, Andrew|Kortylewski, Marcin
PMID: 24154870
Journal: Cancer Res. 2013 Dec 15;73(24):7232-42.
Title: Functional TLR5 genetic variants affect human colorectal cancer survival.
Author: Klimosch, Sascha N|Forsti, Asta|Eckert, Jana|Knezevic, Jelena|Bevier, Melanie|von Schonfels, Witigo|Heits, Nils|Walter, Jessica|Hinz, Sebastian|Lascorz, Jesus|Hampe, Jochen|Hartl, Dominik|Frick, Julia-Stefanie|Hemminki, Kari|Schafmayer, Clemens|Weber, Ale
PMID: 24154872
Journal: Int J Mol Sci. 2014 Dec 24;16(1):159-77.
Title: Upregulation of TLRs and IL-6 as a marker in human colorectal cancer.
Author: Lu, Chien-Chang|Kuo, Hsing-Chun|Wang, Feng-Sheng|Jou, Ming-Huey|Lee, Ko-Chao|Chuang, Jiin-Haur
PMID: 25547486
Journal: Cell Cycle. 2014;13(24):3785-6.
Title: Cell-intrinsic TLR2/MyD88 pathway in breast and colon cancer.
Author: Kuo, Angera H|Scheeren, Ferenc A
PMID: 25457615
Journal: Gene. 2014 Aug 10;546(2):263-70.
Title: Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.
Author: Li, Wen-Liang|Xiao, Mei-Sheng|Zhang, Deng-Feng|Yu, Dandan|Yang, Run-Xiang|Li, Xiao-Yan|Yao, Yong-Gang
PMID: 24887488
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 May 1;306(9):G769-78.
Title: MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
Author: Aviello, Gabriella|Corr, Sinead C|Johnston, Daniel G W|O'Neill, Luke A J|Fallon, Padraic G
PMID: 24603458
Journal: Immunity. 2014 Jan 16;40(1):140-52.
Title: Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis.
Author: Song, Xinyang|Gao, Hanchao|Lin, Yingying|Yao, Yikun|Zhu, Shu|Wang, Jingjing|Liu, Yan|Yao, Xiaomin|Meng, Guangxun|Shen, Nan|Shi, Yufang|Iwakura, Yoichiro|Qian, Youcun
PMID: 24412611
Journal: Adv Healthc Mater. 2014 Sep;3(9):1486-95.
Title: Graphene oxide triggers toll-like receptors/autophagy responses in vitro and inhibits tumor growth in vivo.
Author: Chen, Guan-Yu|Chen, Chiu-Ling|Tuan, Hsing-Yu|Yuan, Pei-Xiang|Li, Kuei-Chang|Yang, Hong-Jie|Hu, Yu-Chen
PMID: 24652749
Journal: Nutr Cancer. 2015;67(1):177-90.
Title: Apple polysaccharide reduces NF-Kb mediated colitis-associated colon carcinogenesis.
Author: Zhang, Dian|Mi, Man|Jiang, Fengliang|Sun, Yang|Li, Yuhua|Yang, Libin|Fan, Lei|Li, Qian|Meng, Jin|Yue, Zhenggang|Liu, Li|Mei, Qibing
PMID: 25412264
Journal: Oncogene. 2015 Oct 8;34(41):5302-8.
Title: Diverse roles of STING-dependent signaling on the development of cancer.
Author: Ahn, J|Konno, H|Barber, G N
PMID: 25639870
Journal: Nat Commun. 2015 Apr 24;6:6956.
Title: Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.
Author: Deng, Zhongbin|Mu, Jingyao|Tseng, Michael|Wattenberg, Binks|Zhuang, Xiaoying|Egilmez, Nejat K|Wang, Qilong|Zhang, Lifeng|Norris, James|Guo, Haixun|Yan, Jun|Haribabu, Bodduluri|Miller, Donald|Zhang, Huang-Ge
PMID: 25907800
Journal: PLoS One. 2015 Jul 2;10(7):e0131699.
Title: Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Author: Furi, Istvan|Kalmar, Alexandra|Wichmann, Barnabas|Spisak, Sandor|Scholler, Andrea|Bartak, Barbara|Tulassay, Zsolt|Molnar, Bela
PMID: 26133168
Journal: PLoS One. 2015 Aug 28;10(8):e0136947.
Title: Roles of TLR/MyD88/MAPK/NF-kappaB Signaling Pathways in the Regulation of Phagocytosis and Proinflammatory Cytokine Expression in Response to E. faecalis Infection.
Author: Zou, Jun|Shankar, Nathan
PMID: 26317438
Journal: J Natl Cancer Inst. 2015 Dec 28;108(4). pii: djv364.
Title: Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.
Author: Xie, Lin|Jiang, Feng-Chao|Zhang, Li-Min|He, Wen-Tao|Liu, Jian-Hua|Li, Ming-Qiang|Zhang, Xue|Xing, Shuai|Guo, Hui|Zhou, Ping
PMID: 26712311
Journal: J Cancer. 2016 Aug 12;7(13):1780-1790.
Title: Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc(+/1638N) Mice: Comparisons and Contrasts.
Author: Liu, Wei|Crott, Jimmy W|Lyu, Lin|Pfalzer, Anna C|Li, Jinchao|Choi, Sang-Woon|Yang, Yingke|Mason, Joel B|Liu, Zhenhua
PMID: 27698916
Journal: FEBS Lett. 2017 May;591(10):1371-1382.
Title: Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3.
Author: Singh, Snahlata|Chouhan, Surbhi|Mohammad, Naoshad|Bhat, Manoj Kumar
PMID: 28417458
Journal: Oncoimmunology. 2017 Aug 10;6(12):e1361593.
Title: Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression.
Author: Jala, Venkatakrishna R|Maturu, Paramahamsa|Bodduluri, Sobha R|Krishnan, Elangovan|Mathis, Steven|Subbarao, Krishnaprasad|Wang, Min|Jenson, Alfred B|Proctor, Mary L|Rouchka, Eric C|Knight, Rob|Haribabu, Bodduluri
PMID: 29209564
Journal: Oncol Lett. 2017 Oct;14(4):4305-4310.
Title: Andrographolide suppresses proliferation of human colon cancer SW620 cells through the TLR4/NF-kappaB/MMP-9 signaling pathway.
Author: Zhang, Rui|Zhao, Jian|Xu, Jian|Jiao, De-Xin|Wang, Jian|Gong, Zhi-Qiang|Jia, Jian-Hui
PMID: 28943944
Journal: Cell. 2017 Jul 27;170(3):548-563.e16.
Title: Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy.
Author: Yu, TaChung|Guo, Fangfang|Yu, Yanan|Sun, Tiantian|Ma, Dan|Han, Jixuan|Qian, Yun|Kryczek, Ilona|Sun, Danfeng|Nagarsheth, Nisha|Chen, Yingxuan|Chen, Haoyan|Hong, Jie|Zou, Weiping|Fang, Jing-Yuan
PMID: 28753429
Journal: Int J Mol Epidemiol Genet. 2017 Apr 15;8(2):8-18. eCollection 2017.
Title: Expression of pattern recognition receptor genes and mortality in patients with colorectal adenocarcinoma.
Author: Royse, Kathryn E|Chen, Liang|Berger, David H|Ittmann, Michael M|El-Serag, Hashem B|Balentine, Courtney J|Graham, David Y|Richardson, Peter A|Rumbaut, Rolando E|Shen, Xiaoyun|White, Donna L|Jiao, Li
PMID: 28533893
Journal: Oncotarget. 2017 Apr 18;8(16):27454-27470.
Title: Multi-factorial modulation of colorectal carcinoma cells motility - partial coordination by the tetraspanin Co-029/tspan8.
Author: Zhu, Yingying|Ailane, Naouel|Sala-Valdes, Monica|Haghighi-Rad, Farhad|Billard, Martine|Nguyen, Viet|Saffroy, Raphael|Lemoine, Antoinette|Rubinstein, Eric|Boucheix, Claude|Greco, Celine
PMID: 28418857
Journal: Cell Death Dis. 2017 Mar 16;8(3):e2667.
Title: Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli.
Author: Sahu, Upasana|Choudhury, Arnab|Parvez, Suhel|Biswas, Subhrajit|Kar, Sudeshna
PMID: 28300841
Journal: Sci Transl Med. 2017 Feb 8;9(376). pii: 9/376/eaak9537.
Title: Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin.
Author: Zheng, Jin Hai|Nguyen, Vu H|Jiang, Sheng-Nan|Park, Seung-Hwan|Tan, Wenzhi|Hong, Seol Hee|Shin, Myung Geun|Chung, Ik-Joo|Hong, Yeongjin|Bom, Hee-Seung|Choy, Hyon E|Lee, Shee Eun|Rhee, Joon Haeng|Min, Jung-Joon
PMID: 28179508
Journal: Gastroenterology. 2017 Mar;152(4):851-866.e24.
Title: Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kappaB, and Up-regulating Expression of MicroRNA-21.
Author: Yang, Yongzhi|Weng, Wenhao|Peng, Junjie|Hong, Leiming|Yang, Lei|Toiyama, Yuji|Gao, Renyuan|Liu, Minfeng|Yin, Mingming|Pan, Cheng|Li, Hao|Guo, Bomin|Zhu, Qingchao|Wei, Qing|Moyer, Mary-Pat|Wang, Ping|Cai, Sanjun|Goel, Ajay|Qin, Huanlong|Ma, Yanlei
PMID: 27876571
Journal: J Cell Biochem. 2018 Feb;119(2):1922-1930.
Title: Loss of BMI-1 dampens migration and EMT of colorectal cancer in inflammatory microenvironment through TLR4/MD-2/MyD88-mediated NF-kappaB signaling.
Author: Ye, Kai|Chen, Qi-Wei|Sun, Ya-Feng|Lin, Jian-An|Xu, Jian-Hua
PMID: 28815730
Journal: Int J Cancer. 2018 Apr 26.
Title: Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice.
Author: Koh, Gar Yee|Kane, Anne|Lee, Kyongbum|Xu, Qiaobing|Wu, Xian|Roper, Jatin|Mason, Joel B|Crott, Jimmy W
PMID: 29696632
Journal: Pharmazie. 2018 Jul 1;73(7):363-368.
Title: Contribution of drugs acting on the TLRs/MyD88 signaling pathway on colitis-associated cancer.
Author: Zhu, Mingliang|Yu, Kewei|Wang, Lu|Yu, Shuwen
PMID: 30001768
Journal: Gastroenterology. 2018 Jul 28. pii: S0016-5085(18)34816-9.
Title: Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.
Author: Coleman, O I|Lobner, E M|Bierwirth, S|Sorbie, A|Waldschmitt, N|Rath, E|Berger, E|Lagkouvardos, I|Clavel, T|McCoy, K D|Weber, A|Heikenwalder, M|Janssen, K P|Haller, D
PMID: 30063920
Journal: Biomed Pharmacother. 2018 Nov;107:177-184.
Title: Dual functional roles of the MyD88 signaling in colorectal cancer development.
Author: Wang, Lu|Yu, Kewei|Zhang, Xiang|Yu, Shuwen
PMID: 30086464
Journal: Oncoimmunology. 2018 Jun 11;7(8):e1466770.
Title: Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy.
Author: Holtorf, Anne|Conrad, Anja|Holzmann, Bernhard|Janssen, Klaus-Peter
PMID: 30221070
Journal: Acta Biochim Biophys Sin (Shanghai). 2018 Sep 15. pii: 5098366.
Title: Cell-free DNA derived from cancer cells facilitates tumor malignancy through Toll-like receptor 9 signaling-triggered interleukin-8 secretion in colorectal cancer.
Author: Niu, Zhengchuan|Tang, Wentao|Liu, Tianyu|Xu, Pingping|Zhu, Dexiang|Ji, Meiling|Huang, Wenbai|Ren, Li|Wei, Ye|Xu, Jianmin
PMID: 30239551