Literatures

Primary Site >> Colorectal Cancer

Gene >> MTR

1.
Journal:	Carcinogenesis. 1998 Dec;19(12):2129-32.
Title:	A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
Author:	Chen, J\|Giovannucci, E\|Hankinson, S E\|Ma, J\|Willett, W C\|Spiegelman, D\|Kelsey, K T\|Hunter, D J
PMID:	9886567

2.
Journal:	Cancer Epidemiol Biomarkers Prev. 1999 Sep;8(9):825-9.
Title:	A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk.
Author:	Ma, J\|Stampfer, M J\|Christensen, B\|Giovannucci, E\|Hunter, D J\|Chen, J\|Willett, W C\|Selhub, J\|Hennekens, C H\|Gravel, R\|Rozen, R
PMID:	10498402

3.
Journal:	Br J Cancer. 2002 Jul 15;87(2):225-30.
Title:	Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines.
Author:	Sekhon, J\|Pereira, P\|Sabbaghian, N\|Schievella, A R\|Rozen, R
PMID:	12107847

4.
Journal:	Asian Pac J Cancer Prev. 2002;3(4):353-359.
Title:	Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer.
Author:	Matsuo, Keitaro\|Hamajima, Nobuyuki\|Hirai, Takashi\|Kato, Tomoyuki\|Inoue, Manami\|Takezaki, Toshiro\|Tajima, Kazuo
PMID:	12716294

5.
Journal:	Cancer Causes Control. 2002 Apr;13(3):239-48.
Title:	B-vitamin intake, metabolic genes, and colorectal cancer risk (United States).
Author:	Le Marchand, Loic\|Donlon, Timothy\|Hankin, Jean H\|Kolonel, Laurence N\|Wilkens, Lynne R\|Seifried, Ann
PMID:	12020105

6.
Journal:	Gastroenterology. 2003 May;124(5):1240-8.
Title:	Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study.
Author:	Pufulete, Maria\|Al-Ghnaniem, Reyad\|Leather, Andrew J M\|Appleby, Paul\|Gout, Sally\|Terry, Catherine\|Emery, Peter W\|Sanders, Thomas A B
PMID:	12730865

7.
Journal:	Hematology Am Soc Hematol Educ Program. 2003:62-81.
Title:	Update on cobalamin, folate, and homocysteine.
Author:	Carmel, Ralph\|Green, Ralph\|Rosenblatt, David S\|Watkins, David
PMID:	14633777

8.
Journal:	Am J Epidemiol. 2004 Mar 1;159(5):423-43.
Title:	Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
Author:	Sharp, Linda\|Little, Julian
PMID:	14977639

9.
Journal:	Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2175-80.
Title:	Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort.
Author:	Ulvik, Arve\|Vollset, Stein Emil\|Hansen, Svein\|Gislefoss, Randi\|Jellum, Egil\|Ueland, Per Magne
PMID:	15598777

10.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2999-3003.
Title:	Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes.
Author:	Lightfoot, Tracy J\|Skibola, Christine F\|Willett, Eleanor V\|Skibola, Danica R\|Allan, James M\|Coppede, Fabio\|Adamson, Peter J\|Morgan, Gareth J\|Roman, Eve\|Smith, Martyn T
PMID:	16365025

11.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2509-16.
Title:	Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
Author:	Ulrich, Cornelia M\|Curtin, Karen\|Potter, John D\|Bigler, Jeannette\|Caan, Bette\|Slattery, Martha L
PMID:	16284371

12.
Journal:	Carcinogenesis. 2005 Dec;26(12):2164-71.
Title:	One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan.
Author:	Matsuo, Keitaro\|Ito, Hidemi\|Wakai, Kenji\|Hirose, Kaoru\|Saito, Toshiko\|Suzuki, Takeshi\|Kato, Tomoyuki\|Hirai, Takashi\|Kanemitsu, Yukihide\|Hamajima, Hiroshi\|Tajima, Kazuo
PMID:	16051637

13.
Journal:	World J Gastroenterol. 2005 Jan 21;11(3):331-5.
Title:	Relationship between metabolic enzyme polymorphism and colorectal cancer.
Author:	Chen, Kun\|Jiang, Qin-Ting\|He, Han-Qing
PMID:	15637738

14.
Journal:	J Cell Biochem. 2006 Sep 1;99(1):146-55.
Title:	Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.
Author:	Singh, R\|Fouladi-Nashta, A A\|Li, D\|Halliday, N\|Barrett, D A\|Sinclair, K D
PMID:	16598758

15.
Journal:	Zhonghua Zhong Liu Za Zhi. 2006 Jun;28(6):429-32.
Title:	[Association between genetic polymorphisms in folate metabolic enzyme genes and colorectal cancer: a nested case-control study].
Author:	Chen, Kun\|Song, Liang\|Jin, Ming-Juan\|Fan, Chun-Hong\|Jiang, Qin-Ting\|Yu, Wei-Ping
PMID:	17152488

16.
Journal:	J Nutr Biochem. 2007 May;18(5):305-12.
Title:	Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice.
Author:	Lawrance, Andrea K\|Deng, Liyuan\|Brody, Lawrence C\|Finnell, Richard H\|Shane, Barry\|Rozen, Rima
PMID:	16963246

17.
Journal:	Carcinogenesis. 2007 Aug;28(8):1672-9. Epub 2007 Apr 21.
Title:	Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet.
Author:	Curtin, Karen\|Slattery, Martha L\|Ulrich, Cornelia M\|Bigler, Jeannette\|Levin, Theodore R\|Wolff, Roger K\|Albertsen, Hans\|Potter, John D\|Samowitz, Wade S
PMID:	17449906

18.
Journal:	J Cancer Res Clin Oncol. 2008 Mar;134(3):405-10.
Title:	Polymorphisms in methionine synthase (A2756G) and cystathionine beta-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract.
Author:	Ott, N\|Geddert, H\|Sarbia, M
PMID:	17726616

19.
Journal:	Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):171-82.
Title:	Dietary vitamin B6 intake and the risk of colorectal cancer.
Author:	Theodoratou, Evropi\|Farrington, Susan M\|Tenesa, Albert\|McNeill, Geraldine\|Cetnarskyj, Roseanne\|Barnetson, Rebecca A\|Porteous, Mary E\|Dunlop, Malcolm G\|Campbell, Harry
PMID:	18199722

20.
Journal:	Am J Clin Nutr. 2008 Oct;88(4):1149-58.
Title:	Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Author:	DeVos, Lauren\|Chanson, Aurelie\|Liu, Zhenhua\|Ciappio, Eric D\|Parnell, Laurence D\|Mason, Joel B\|Tucker, Katherine L\|Crott, Jimmy W
PMID:	18842806

21.
Journal:	Am J Clin Nutr. 2008 Nov;88(5):1413-8.
Title:	Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients.
Author:	Guerreiro, Catarina Sousa\|Carmona, Bruno\|Goncalves, Susana\|Carolino, Elisabete\|Fidalgo, Paulo\|Brito, Miguel\|Leitao, Carlos Nobre\|Cravo, Marilia
PMID:	18996879

22.
Journal:	J Nutrigenet Nutrigenomics. 2008;1(4):196-204.
Title:	Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.
Author:	Steck, Susan E\|Keku, Temitope\|Butler, Lesley M\|Galanko, Joseph\|Massa, Beri\|Millikan, Robert C\|Sandler, Robert S
PMID:	19776626

23.
Journal:	Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3086-96.
Title:	Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.
Author:	de Vogel, Stefan\|Wouters, Kim A D\|Gottschalk, Ralph W H\|van Schooten, Frederik J\|de Goeij, Anton F P M\|de Bruine, Adriaan P\|Goldbohm, Royle A\|van den Brandt, Piet A\|Weijenberg, Matty P\|van Engeland, Manon
PMID:	19843671

24.
Journal:	Mol Med. 2010 Sep-Oct;16(9-10):425-32.
Title:	MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer.
Author:	Wettergren, Yvonne\|Odin, Elisabeth\|Carlsson, Goran\|Gustavsson, Bengt
PMID:	20549016

25.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1812-21.
Title:	A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
Author:	Levine, A Joan\|Figueiredo, Jane C\|Lee, Won\|Conti, David V\|Kennedy, Kathleen\|Duggan, David J\|Poynter, Jenny N\|Campbell, Peter T\|Newcomb, Polly\|Martinez, Maria Elena\|Hopper, John L\|Le Marchand, Loic\|Baron, John A\|Limburg, Paul J\|Ulrich, Cornelia M\|Haile, Ro
PMID:	20615890

26.
Journal:	Eur J Hum Genet. 2010 Mar;18(3):370-8.
Title:	Methionine synthase A2756G polymorphism and cancer risk: a meta-analysis.
Author:	Yu, Ke\|Zhang, Jing\|Zhang, Jiyuan\|Dou, Chao\|Gu, Shaohua\|Xie, Yi\|Mao, Yumin\|Ji, Chaoneng
PMID:	19826453

27.
Journal:	Cancer Causes Control. 2011 Jan;22(1):1-12.
Title:	Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
Author:	de Vogel, Stefan\|Wouters, Kim A D\|Gottschalk, Ralph W H\|van Schooten, Frederik J\|de Goeij, Anton F P M\|de Bruine, Adriaan P\|Goldbohm, R Alexandra\|van den Brandt, Piet A\|van Engeland, Manon\|Weijenberg, Matty P
PMID:	20960050

28.
Journal:	Oncol Rep. 2011 Jan;25(1):167-72.
Title:	Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients.
Author:	Kim, Jong Woo\|Park, Hye Mi\|Choi, Young-Kook\|Chong, So Young\|Oh, Doyeun\|Kim, Nam Keun
PMID:	21109973

29.
Journal:	DNA Cell Biol. 2011 Oct;30(10):771-6.
Title:	Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer.
Author:	Jokic, Mladen\|Brcic-Kostic, Krunoslav\|Stefulj, Jasminka\|Catela Ivkovic, Tina\|Bozo, Loncar\|Gamulin, Marija\|Kapitanovic, Sanja
PMID:	21438757

30.
Journal:	Int J Mol Epidemiol Genet. 2011 Jan 1;2(1):1-8. Epub 2010 Nov 5.
Title:	Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
Author:	Curtin, Karen\|Ulrich, Cornelia M\|Samowitz, Wade S\|Wolff, Roger K\|Duggan, David J\|Makar, Karen W\|Caan, Bette J\|Slattery, Martha L
PMID:	21537397

31.
Journal:	Tumour Biol. 2011 Oct;32(5):853-61.
Title:	Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Author:	Guimaraes, Jose Luiz Miranda\|Ayrizono, Maria de Lurdes\|Coy, Claudio Saddy Rodrigues\|Lima, Carmen Silvia Passos
PMID:	21603981

32.
Journal:	Mol Biol Rep. 2012 Feb;39(2):805-16.
Title:	Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies.
Author:	Han, Dong\|Shen, Chao\|Meng, Xiangning\|Bai, Jing\|Chen, Feng\|Yu, Yang\|Jin, Yan\|Fu, Songbin
PMID:	21547363

33.
Journal:	Int J Biol Sci. 2012;8(6):819-30.
Title:	The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.
Author:	Zhou, Daijun\|Mei, Qiang\|Luo, Han\|Tang, Bo\|Yu, Peiwu
PMID:	22719222

34.
Journal:	PLoS One. 2013 Apr 9;8(4):e60508.
Title:	Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies.
Author:	Ding, Weixing\|Zhou, Dong-Lei\|Jiang, Xun\|Lu, Lie-Sheng
PMID:	23593229

35.
Journal:	Asian Pac J Cancer Prev. 2013;14(11):6249-56.
Title:	Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the fukuoka colorectal cancer study.
Author:	Morita, Makiko\|Yin, Guang\|Yoshimitsu, Shin-ichiro\|Ohnaka, Keizo\|Toyomura, Kengo\|Kono, Suminori\|Ueki, Takashi\|Tanaka, Masao\|Kakeji, Yoshihiro\|Maehara, Yoshihiko\|Okamura, Takeshi\|Ikejiri, Koji\|Futami, Kitaroh\|Maekawa, Takafumi\|Yasunami, Yohichi\|Takenaka, Ke
PMID:	24377513

36.
Journal:	Mol Nutr Food Res. 2013 Apr;57(4):607-27.
Title:	Folate-genetics and colorectal neoplasia: what we know and need to know next.
Author:	Figueiredo, Jane C\|Levine, A Joan\|Crott, Jimmy W\|Baurley, James\|Haile, Robert W
PMID:	23401104

37.
Journal:	Epigenetics. 2014 Apr;9(4):621-33.
Title:	Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism.
Author:	Coppede, Fabio\|Migheli, Francesca\|Lopomo, Angela\|Failli, Alessandra\|Legitimo, Annalisa\|Consolini, Rita\|Fontanini, Gabriella\|Sensi, Elisa\|Servadio, Adele\|Seccia, Massimo\|Zocco, Giuseppe\|Chiarugi, Massimo\|Spisni, Roberto\|Migliore, Lucia
PMID:	24500500

38.
Journal:	Clin Med Insights Oncol. 2014 Feb 17;8:15-20.
Title:	Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer.
Author:	Taflin, Helena\|Wettergren, Yvonne\|Odin, Elisabeth\|Carlsson, Goran\|Derwinger, Kristoffer
PMID:	24596472

39.
Journal:	Cell Oncol (Dordr). 2014 Dec;37(6):455-61.
Title:	Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity--a short report.
Author:	Oh, Hye Rim\|An, Chang Hyeok\|Yoo, Nam Jin\|Lee, Sug Hyung
PMID:	25450519

40.
Journal:	Epigenomics. 2015;7(2):175-86.
Title:	Application of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer.
Author:	Coppede, Fabio\|Grossi, Enzo\|Lopomo, Angela\|Spisni, Roberto\|Buscema, Massimo\|Migliore, Lucia
PMID:	25942531

41.
Journal:	PLoS One. 2017 Oct 2;12(10):e0185792.
Title:	One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.
Author:	Moruzzi, Sara\|Guarini, Patrizia\|Udali, Silvia\|Ruzzenente, Andrea\|Guglielmi, Alfredo\|Conci, Simone\|Pattini, Patrizia\|Martinelli, Nicola\|Olivieri, Oliviero\|Tammen, Stephanie A\|Choi, Sang-Woon\|Friso, Simonetta
PMID:	28968444

42.
Journal:	J Pers Med. 2018 Feb 16;8(1). pii: jpm8010010.
Title:	Gene Environment Interactions and Predictors of Colorectal Cancer in Family-Based, Multi-Ethnic Groups.
Author:	Shiao, S Pamela K\|Grayson, James\|Yu, Chong Ho\|Wasek, Brandi\|Bottiglieri, Teodoro
PMID:	29462916

43.
Journal:	Cancer Chemother Pharmacol. 2018 Aug;82(2):237-243.
Title:	The association of polymorphisms in folate-metabolizing genes with response to adjuvant chemotherapy of colorectal cancer.
Author:	Yousef, Al-Motassem\|Zawiah, Mohammed\|Al-Yacoub, Shorouq\|Kadi, Taha\|Tantawi, Dua' A\|Al-Ramadhani, Hanguin
PMID:	29845393

44.
Journal:	Nutrients. 2018 Jun 20;10(6). pii: nu10060795.
Title:	Personalized Nutrition-Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families.
Author:	Shiao, S Pamela K\|Grayson, James\|Lie, Amanda\|Yu, Chong Ho
PMID:	29925788

45.
Journal:	J Pers Med. 2018 Aug 6;8(3). pii: jpm8030026.
Title:	Gene-Metabolite Interaction in the One Carbon Metabolism Pathway: Predictors of Colorectal Cancer in Multi-Ethnic Families.
Author:	Shiao, S Pamela K\|Grayson, James\|Yu, Chong Ho
PMID:	30082654