Primary Site >> Colorectal Cancer
Gene >> MTR
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Ref: A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. PMID: 9886567 |
Ref: A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. PMID: 10498402 |
Ref: B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). PMID: 12020105 Ref: Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines. PMID: 12107847 Ref: Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer. PMID: 12716294 |
Ref: Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. PMID: 12730865 Ref: Update on cobalamin, folate, and homocysteine. PMID: 14633777 |
Ref: Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. PMID: 14977639 Ref: Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. PMID: 15598777 |
Ref: Relationship between metabolic enzyme polymorphism and colorectal cancer. PMID: 15637738 Ref: One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan. PMID: 16051637 Ref: Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. PMID: 16284371 Ref: Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. PMID: 16365025 |
Ref: Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. PMID: 16598758 Ref: [Association between genetic polymorphisms in folate metabolic enzyme genes and colorectal cancer: a nested case-control study]. PMID: 17152488 |
Ref: Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice. PMID: 16963246 Ref: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. PMID: 17449906 |
Ref: Polymorphisms in methionine synthase (A2756G) and cystathionine beta-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract. PMID: 17726616 Ref: Dietary vitamin B6 intake and the risk of colorectal cancer. PMID: 18199722 Ref: Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. PMID: 18842806 Ref: Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients. PMID: 18996879 Ref: Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk. PMID: 19776626 |
Ref: Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. PMID: 19843671 |
Ref: Methionine synthase A2756G polymorphism and cancer risk: a meta-analysis. PMID: 19826453 Ref: MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer. PMID: 20549016 Ref: A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. PMID: 20615890 |
Ref: Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer. PMID: 20960050 Ref: Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients. PMID: 21109973 Ref: Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer. PMID: 21438757 Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. PMID: 21537397 Ref: Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma. PMID: 21603981 |
Ref: Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies. PMID: 21547363 Ref: The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer. PMID: 22719222 |
Ref: Folate-genetics and colorectal neoplasia: what we know and need to know next. PMID: 23401104 Ref: Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies. PMID: 23593229 Ref: Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the fukuoka colorectal cancer study. PMID: 24377513 |
Ref: Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism. PMID: 24500500 Ref: Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer. PMID: 24596472 Ref: Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity--a short report. PMID: 25450519 |
Ref: Application of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer. PMID: 25942531 |
Ref: One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. PMID: 28968444 |
Ref: Gene Environment Interactions and Predictors of Colorectal Cancer in Family-Based, Multi-Ethnic Groups. PMID: 29462916 Ref: The association of polymorphisms in folate-metabolizing genes with response to adjuvant chemotherapy of colorectal cancer. PMID: 29845393 Ref: Personalized Nutrition-Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families. PMID: 29925788 Ref: Gene-Metabolite Interaction in the One Carbon Metabolism Pathway: Predictors of Colorectal Cancer in Multi-Ethnic Families. PMID: 30082654 |