Literatures

Primary Site >> Pancreatic Cancer

Gene >> MTOR

1.
Journal:	Cancer Res. 1999 Aug 1;59(15):3581-7.
Title:	Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells.
Author:	Grewe, M\|Gansauge, F\|Schmid, R M\|Adler, G\|Seufferlein, T
PMID:	10446965

2.
Journal:
Title:	Pathophysiology and Treatment of Pancreatic Neuroendocrine Tumors (PNETs): New Developments
Author:	Vinik, Aaron\|Perry, Roger R\|Casellini, Carolina\|Hughes, Marybeth S\|Feliberti, Eric
PMID:	25905300

3.
Journal:	J Surg Res. 2001 May 15;97(2):123-30.
Title:	FRAP-p70s6K signaling is required for pancreatic cancer cell proliferation.
Author:	Shah, S A\|Potter, M W\|Ricciardi, R\|Perugini, R A\|Callery, M P
PMID:	11341787

4.
Journal:	Int J Gastrointest Cancer. 2002;31(1-3):15-21.
Title:	Novel protein kinases in pancreatic cell growth and cancer.
Author:	Seufferlein, Thomas
PMID:	12622411

5.
Journal:	Cancer Res. 2005 Feb 15;65(4):1497-504.
Title:	Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenograf
Author:	Yau, Cindy Y F\|Wheeler, Jeffery J\|Sutton, Kymberley L\|Hedley, David W
PMID:	15735038

6.
Journal:	Biochem Biophys Res Commun. 2005 May 27;331(1):295-302.
Title:	The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation.
Author:	Asano, Takayuki\|Yao, Yixin\|Zhu, Jijiang\|Li, Donghui\|Abbruzzese, James L\|Reddy, Shrikanth A
PMID:	15845392

7.
Journal:	Curr Cancer Drug Targets. 2005 May;5(3):171-93.
Title:	Molecularly targeted therapy for gastrointestinal cancer.
Author:	Wiedmann, Marcus W\|Caca, Karel
PMID:	15892618

8.
Journal:	Int J Cancer. 2006 May 1;118(9):2337-43.
Title:	In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer.
Author:	Ito, Daisuke\|Fujimoto, Koji\|Mori, Tomohiko\|Kami, Kazuhiro\|Koizumi, Masayuki\|Toyoda, Eiji\|Kawaguchi, Yoshiya\|Doi, Ryuichiro
PMID:	16331623

9.
Journal:	J Pathol. 2007 Mar;211(4):481-8.
Title:	Endothelial cell KIT expression in human tumours.
Author:	Sihto, H\|Tynninen, O\|Butzow, R\|Saarialho-Kere, U\|Joensuu, H
PMID:	17294421

10.
Journal:	J Mol Med (Berl). 2007 Jun;85(6):647-54. Epub 2007 Mar 2.
Title:	Activity of the Akt-dependent anabolic and catabolic pathways in muscle and liver samples in cancer-related cachexia.
Author:	Schmitt, Thomas L\|Martignoni, Marcus E\|Bachmann, Jeannine\|Fechtner, Kerstin\|Friess, Helmut\|Kinscherf, Ralf\|Hildebrandt, Wulf
PMID:	17333095

11.
Journal:	Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5103-8. Epub 2007 Mar 19.
Title:	Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.
Author:	Morton, Jennifer P\|Mongeau, Michelle E\|Klimstra, David S\|Morris, John P\|Lee, Yie Chia\|Kawaguchi, Yoshiya\|Wright, Christopher V E\|Hebrok, Matthias\|Lewis, Brian C
PMID:	17372229

12.
Journal:	Cancer Biol Ther. 2007 Apr;6(4):548-54.
Title:	ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib.
Author:	Frolov, Andrey\|Schuller, Kyle\|Tzeng, Ching-Wei D\|Cannon, Emily E\|Ku, Brandon C\|Howard, J Harrison\|Vickers, Selwyn M\|Heslin, Martin J\|Buchsbaum, Donald J\|Arnoletti, J Pablo
PMID:	17457047

13.
Journal:	IUBMB Life. 2007 Nov;59(11):717-21.
Title:	Sirolimus inhibits human pancreatic carcinoma cell proliferation by a mechanism linked to the targeting of mTOR/HIF-1 alpha/VEGF signaling.
Author:	Wang, Yu\|Zhao, Qiu\|Ma, Songlin\|Yang, Fang\|Gong, Yong\|Ke, Changshu
PMID:	17968710

14.
Journal:	World J Gastroenterol. 2007 Nov 28;13(44):5845-56.
Title:	Exploiting novel molecular targets in gastrointestinal cancers.
Author:	Ma, Wen W\|Hidalgo, Manuel
PMID:	17990350

15.
Journal:	Cell Cycle. 2007 Nov 15;6(22):2840-5.
Title:	Suppression of TGF-beta signaling by phospholipase D.
Author:	Gadir, Noga\|Lee, Evan\|Garcia, Avalon\|Toschi, Alfredo\|Foster, David A
PMID:	18032924

16.
Journal:	Hepatogastroenterology. 2007 Oct-Nov;54(79):2129-33.
Title:	Rapamycin enhances the anti-tumor effect of gemcitabine in pancreatic cancer cells.
Author:	Okada, Toshie\|Sawada, Tokihiko\|Kubota, Keiichi
PMID:	18251175

17.
Journal:	Oncogene. 2008 Feb 14;27(8):1055-62. Epub 2007 Aug 13.
Title:	Defective TGF-beta signaling sensitizes human cancer cells to rapamycin.
Author:	Gadir, N\|Jackson, D N\|Lee, E\|Foster, D A
PMID:	17700525

18.
Journal:	Biochem Pharmacol. 2008 Mar 1;75(5):1035-44.
Title:	Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells.
Author:	Azzariti, Amalia\|Porcelli, Letizia\|Gatti, Giuliana\|Nicolin, Angelo\|Paradiso, Angelo
PMID:	18191814

19.
Journal:	Clin Cancer Res. 2008 Feb 1;14(3):892-900.
Title:	Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer.
Author:	Manegold, Philipp C\|Paringer, Carmen\|Kulka, Ulrike\|Krimmel, Klaus\|Eichhorn, Martin E\|Wilkowski, Ralf\|Jauch, Karl-Walter\|Guba, Markus\|Bruns, Christiane J
PMID:	18245553

20.
Journal:	BMC Cancer. 2008 Feb 6;8:43.
Title:	Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis.
Author:	Pham, Nhu-An\|Schwock, Joerg\|Iakovlev, Vladimir\|Pond, Greg\|Hedley, David W\|Tsao, Ming-Sound
PMID:	18254976

21.
Journal:	J Clin Oncol. 2008 Apr 1;26(10):1596-602.
Title:	Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data.
Author:	Tanaka, Chiaki\|O'Reilly, Terence\|Kovarik, John M\|Shand, Nicholas\|Hazell, Katharine\|Judson, Ian\|Raymond, Eric\|Zumstein-Mecker, Sabine\|Stephan, Christine\|Boulay, Anne\|Hattenberger, Marc\|Thomas, George\|Lane, Heidi A
PMID:	18332467

22.
Journal:	Cancer Metastasis Rev. 2008 Sep;27(3):495-522.
Title:	Pancreatic cancer: from molecular pathogenesis to targeted therapy.
Author:	Strimpakos, Alexios\|Saif, Muhammad W\|Syrigos, Kostas N
PMID:	18427734

23.
Journal:	Curr Opin Oncol. 2008 Jul;20(4):454-8.
Title:	Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer?
Author:	Laurent-Puig, Pierre\|Taieb, Julien
PMID:	18525343

24.
Journal:	Expert Rev Anticancer Ther. 2008 Aug;8(8):1331-8.
Title:	Biologic therapies for advanced pancreatic cancer.
Author:	He, Aiwu Ruth\|Lindenberg, Andreas Peter\|Marshall, John Lindsay
PMID:	18699769

25.
Journal:	Expert Rev Gastroenterol Hepatol. 2008 Oct;2(5):673-96.
Title:	New treatment options for advanced pancreatic cancer.
Author:	Middleton, Gary\|Ghaneh, Paula\|Costello, Eithne\|Greenhalf, William\|Neoptolemos, John P
PMID:	19072345

26.
Journal:	Zhonghua Yi Xue Za Zhi. 2008 Nov 18;88(42):2994-8.
Title:	[Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells].
Author:	Zhou, Jing\|Wang, Chun-you\|Liu, Tao\|Wu, He-shui\|Zhou, Feng\|Xiong, Jiong-xin\|Zhao, Gang\|Yang, Ming\|Yin, Tao\|Zhou, Meng-tao
PMID:	19080079

27.
Journal:	J Gastroenterol. 2008;43(12):905-11.
Title:	Molecular targeting therapy for pancreatic cancer: current knowledge and perspectives from bench to bedside.
Author:	Furukawa, Toru
PMID:	19107333

28.
Journal:	J Clin Oncol. 2009 Jan 10;27(2):193-8.
Title:	Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer.
Author:	Wolpin, Brian M\|Hezel, Aram F\|Abrams, Thomas\|Blaszkowsky, Lawrence S\|Meyerhardt, Jeffrey A\|Chan, Jennifer A\|Enzinger, Peter C\|Allen, Brittany\|Clark, Jeffrey W\|Ryan, David P\|Fuchs, Charles S
PMID:	19047305

29.
Journal:	Cancer Res. 2009 Feb 15;69(4):1350-7.
Title:	Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta.
Author:	Kwon, Junhye\|Stephan, Susann\|Mukhopadhyay, Ananya\|Muders, Michael H\|Dutta, Shamit K\|Lau, Julie S\|Mukhopadhyay, Debabrata
PMID:	19190347

30.
Journal:	Leuk Res. 2009 Jul;33(7):883-5.
Title:	New insights into the role of the tuberous sclerosis genes in leukemia.
Author:	Rosner, Margit\|Fuchs, Christiane\|Siegel, Nicol\|Valli, Alessandro\|Hengstschlager, Markus
PMID:	19286253

31.
Journal:	Br J Cancer. 2009 Apr 21;100(8):1267-76.
Title:	Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts.
Author:	Cao, P\|Maira, S-M\|Garcia-Echeverria, C\|Hedley, D W
PMID:	19319133

32.
Journal:	Gastroenterology. 2009 Sep;137(3):1102-13.
Title:	Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.
Author:	Mueller, Maria-Theresa\|Hermann, Patrick C\|Witthauer, Juliane\|Rubio-Viqueira, Belen\|Leicht, Simon F\|Huber, Stephan\|Ellwart, Joachim W\|Mustafa, Mona\|Bartenstein, Peter\|D'Haese, Jan G\|Schoenberg, Michael H\|Berger, Frank\|Jauch, Karl-Walter\|Hidalgo, Manuel\|Hee
PMID:	19501590

33.
Journal:	Cancer Res. 2009 Aug 15;69(16):6539-45.
Title:	Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.
Author:	Kisfalvi, Krisztina\|Eibl, Guido\|Sinnett-Smith, James\|Rozengurt, Enrique
PMID:	19679549

34.
Journal:	J Hematol Oncol. 2009 Oct 27;2:45.
Title:	Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy.
Author:	Yuan, Ruirong\|Kay, Andrea\|Berg, William J\|Lebwohl, David
PMID:	19860903

35.
Journal:	Cancer Biol Ther. 2009 Oct;8(20):1893-901. Epub 2009 Oct 6.
Title:	Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models.
Author:	Chang, Qing\|Chen, Eric\|Hedley, David W
PMID:	20009539

36.
Journal:	Cell Death Differ. 2010 Apr;17(4):666-76.
Title:	The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival.
Author:	Kang, R\|Tang, D\|Schapiro, N E\|Livesey, K M\|Farkas, A\|Loughran, P\|Bierhaus, A\|Lotze, M T\|Zeh, H J
PMID:	19834494

37.
Journal:	Oncogene. 2010 Feb 4;29(5):674-86.
Title:	Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice.
Author:	Xu, X\|Ehdaie, B\|Ohara, N\|Yoshino, T\|Deng, C-X
PMID:	19901970

38.
Journal:	Biochim Biophys Acta. 2010 Apr;1803(4):435-42.
Title:	Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells.
Author:	Lang, Sven A\|Hackl, Christina\|Moser, Christian\|Fichtner-Feigl, Stefan\|Koehl, Gudrun E\|Schlitt, Hans J\|Geissler, Edward K\|Stoeltzing, Oliver
PMID:	20116405

39.
Journal:	Exp Mol Pathol. 2010 Jun;88(3):363-70.
Title:	Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells.
Author:	Ishiwata, Toshiyuki\|Yamamoto, Tetsushi\|Kawahara, Kiyoko\|Kawamoto, Yoko\|Matsuda, Yoko\|Ishiwata, Shunji\|Naito, Zenya
PMID:	20138170

40.
Journal:	Clin Cancer Res. 2010 May 1;16(9):2505-11.
Title:	Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer.
Author:	Rozengurt, Enrique\|Sinnett-Smith, James\|Kisfalvi, Krisztina
PMID:	20388847

41.
Journal:	BMC Cancer. 2010 Apr 27;10:161.
Title:	Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.
Author:	Xu, Zekuan\|Zhang, Yi\|Jiang, Jiakai\|Yang, Yang\|Shi, Ruihua\|Hao, Bo\|Zhang, Zhihong\|Huang, Zuhu\|Kim, Jin W\|Zhang, Guoxin
PMID:	20423485

42.
Journal:	BMC Cancer. 2010 Jul 14;10:368.
Title:	Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies.
Author:	Javle, Milind M\|Shroff, Rachna T\|Xiong, Henry\|Varadhachary, Gauri A\|Fogelman, David\|Reddy, Shrikanth A\|Davis, Darren\|Zhang, Yujian\|Wolff, Robert A\|Abbruzzese, James L
PMID:	20630061

43.
Journal:	PLoS One. 2010 Jul 15;5(7):e11607.
Title:	DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism.
Author:	Wang, Ying\|Gao, Wenli\|Svitkin, Yuri V\|Chen, Annie Pei-Chun\|Cheng, Yung-Chi
PMID:	20657652

44.
Journal:	Br J Cancer. 2010 Aug 24;103(5):649-55.
Title:	Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer.
Author:	Garrido-Laguna, I\|Tan, A C\|Uson, M\|Angenendt, M\|Ma, W W\|Villaroel, M C\|Zhao, M\|Rajeshkumar, N V\|Jimeno, A\|Donehower, R\|Iacobuzio-Donahue, C\|Barrett, M\|Rudek, M A\|Rubio-Viqueira, B\|Laheru, D\|Hidalgo, M
PMID:	20664591

45.
Journal:	BMC Cancer. 2010 Sep 28;10:515.
Title:	Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts.
Author:	Chang, Qing\|Chapman, Mark S\|Miner, Jeffrey N\|Hedley, David W
PMID:	20920162

46.
Journal:	Semin Oncol. 2010 Dec;37(6):594-618.
Title:	Pancreatic endocrine tumors.
Author:	Oberg, Kjell
PMID:	21167379

47.
Journal:	Cancers (Basel). 2010 Dec;2(4):1779-93.
Title:	CDDO-Me: A Novel Synthetic Triterpenoid for the Treatment of Pancreatic Cancer.
Author:	Deeb, Dorrah\|Gao, Xiaohua\|Arbab, Ali S\|Barton, Kenneth\|Dulchavsky, Scott A\|Gautam, Subhash C
PMID:	21799944

48.
Journal:	Cancer Treat Rev. 2011 Apr;37(2):127-32.
Title:	Advances in the systemic treatment of pancreatic neuroendocrine tumors.
Author:	Yalcin, Suayib
PMID:	20705397

49.
Journal:	Cancer Chemother Pharmacol. 2011 Jul;68(1):127-38.
Title:	Novel small molecule drugs inhibit tumor cell metabolism and show potent anti-tumorigenic potential.
Author:	Trojel-Hansen, Christina\|Erichsen, Kamille Dumong\|Christensen, Mette Knak\|Jensen, Peter Buhl\|Sehested, Maxwell\|Nielsen, Soren Jensby
PMID:	20852860

50.
Journal:	Autophagy. 2011 Jan;7(1):91-3.
Title:	Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE).
Author:	Kang, Rui\|Tang, Daolin\|Loze, Michael T\|Zeh, Herbert J
PMID:	20978368

51.
Journal:	Cancer Sci. 2011 Jan;102(1):219-25.
Title:	Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway.
Author:	He, Lijun\|Wu, Yuanyuan\|Lin, Lei\|Wang, Jieqiong\|Wu, Yougen\|Chen, Yihua\|Yi, Zhengfang\|Liu, Mingyao\|Pang, Xiufeng
PMID:	21087351

52.
Journal:	J Clin Oncol. 2011 Feb 20;29(6):e150-3.
Title:	mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.
Author:	Klumpen, Heinz-Josef\|Queiroz, Karla C S\|Spek, C Arnold\|van Noesel, Carel J M\|Brink, Helmy C\|de Leng, Wendy W J\|de Wilde, Roeland F\|Mathus-Vliegen, Elisabeth M H\|Offerhaus, G Johan A\|Alleman, Maarten A\|Westermann, Anneke M\|Richel, Dirk J
PMID:	21189378

53.
Journal:	Clin Cancer Res. 2011 Apr 1;17(7):1784-95.
Title:	Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway.
Author:	Boreddy, Srinivas Reddy\|Pramanik, Kartick C\|Srivastava, Sanjay K
PMID:	21350002

54.
Journal:	Anticancer Agents Med Chem. 2011 Jun;11(5):427-33.
Title:	Insulin-like growth factor signaling as a therapeutic target in pancreatic cancer.
Author:	Rieder, Simon\|Michalski, Christoph W\|Friess, Helmut\|Kleeff, Jorg
PMID:	21492074

55.
Journal:	Anticancer Agents Med Chem. 2011 Jun;11(5):455-63.
Title:	Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials.
Author:	Falasca, Marco\|Selvaggi, Federico\|Buus, Richard\|Sulpizio, Sara\|Edling, Charlotte E
PMID:	21521159

56.
Journal:	Mod Pathol. 2011 Sep;24(9):1229-36.
Title:	Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma.
Author:	de Wilde, Roeland F\|Ottenhof, Niki A\|Jansen, Marnix\|Morsink, Folkert H M\|de Leng, Wendy W J\|Offerhaus, G Johan A\|Brosens, Lodewijk A A
PMID:	21572398

57.
Journal:	Cancer Prev Res (Phila). 2011 Jul;4(7):1041-51.
Title:	Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer.
Author:	Lashinger, Laura M\|Malone, Lauren M\|Brown, Graham W\|Daniels, Elizabeth A\|Goldberg, Jason A\|Otto, Glen\|Fischer, Susan M\|Hursting, Stephen D
PMID:	21593197

58.
Journal:	J Hematol Oncol. 2011 Jun 14;4:29.
Title:	Evolving diagnostic and treatment strategies for pancreatic neuroendocrine tumors.
Author:	Kulke, Matthew H\|Bendell, Johanna\|Kvols, Larry\|Picus, Joel\|Pommier, Rodney\|Yao, James
PMID:	21672194

59.
Journal:	J Mol Med (Berl). 2011 Sep;89(9):877-89.
Title:	Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma.
Author:	Mirzoeva, Olga K\|Hann, Byron\|Hom, Yun K\|Debnath, Jayanta\|Aftab, Dana\|Shokat, Kevan\|Korn, W Michael
PMID:	21678117

60.
Journal:	JOP. 2011 Jul 8;12(4):316-21.
Title:	Pancreatic neoplasm in 2011: an update.
Author:	Saif, Muhammad Wasif
PMID:	21737886

61.
Journal:	Mol Cancer Ther. 2011 Dec;10(12):2426-36.
Title:	GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.
Author:	Wallin, Jeffrey J\|Edgar, Kyle A\|Guan, Jane\|Berry, Megan\|Prior, Wei Wei\|Lee, Leslie\|Lesnick, John D\|Lewis, Cristina\|Nonomiya, Jim\|Pang, Jodie\|Salphati, Laurent\|Olivero, Alan G\|Sutherlin, Daniel P\|O'Brien, Carol\|Spoerke, Jill M\|Patel, Sonal\|Lensun, Letitia\|
PMID:	21998291

62.
Journal:	Mol Cancer. 2011 Nov 10;10:138.
Title:	Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.
Author:	Vo, Kevin\|Amarasinghe, Barushi\|Washington, Kay\|Gonzalez, Adriana\|Berlin, Jordan\|Dang, Thao P
PMID:	22074495

63.
Journal:	Drugs Today (Barc). 2011 Oct;47(10):773-86.
Title:	Current treatment options for neuroendocrine tumors.
Author:	Horsch, D\|Grabowski, P\|Schneider, C P\|Petrovitch, A\|Kaemmerer, D\|Hommann, M\|Baum, R P
PMID:	22076492

64.
Journal:	Oncology. 2011;81(3-4):259-72.
Title:	Molecular pathogenesis of pancreatic cancer and clinical perspectives.
Author:	Matthaios, D\|Zarogoulidis, P\|Balgouranidou, I\|Chatzaki, E\|Kakolyris, S
PMID:	22116519

65.
Journal:	Small GTPases. 2011 Sep;2(5):264-267.
Title:	Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy.
Author:	Kennedy, Alyssa L\|Adams, Peter D\|Morton, Jennifer P
PMID:	22292129

66.
Journal:	Zhonghua Yi Xue Za Zhi. 2011 Sep 27;91(36):2564-7.
Title:	[RAD001 reverses radio-resistance and exerts synergistic tumor inhibition with 5-fluorouracil].
Author:	Xin, Ying\|Cong, Wei\|Zhou, Ning\|Hong, De-Fei\|Cai, Xiu-Jun
PMID:	22321888

67.
Journal:	J Gastrointest Oncol. 2011 Jun;2(2):93-103.
Title:	Emerging therapies in pancreas cancer.
Author:	Kotowski, Adam\|Ma, Wen W
PMID:	22811835

68.
Journal:	Invest New Drugs. 2012 Aug;30(4):1614-20.
Title:	A phase 2 study of oral MKC-1, an inhibitor of importin-beta, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.
Author:	Faris, Jason E\|Arnott, Jamie\|Zheng, Hui\|Ryan, David P\|Abrams, Thomas A\|Blaszkowsky, Lawrence S\|Clark, Jeffrey W\|Enzinger, Peter C\|Hezel, Aram F\|Ng, Kimmie\|Wolpin, Brian M\|Kwak, Eunice L
PMID:	21800081

69.
Journal:	J Nutr Biochem. 2012 Aug;23(8):900-7.
Title:	Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.
Author:	Yu, Chia-Chun\|Chiang, Po-Cheng\|Lu, Pin-Hsuan\|Kuo, Mao-Tien\|Wen, Wu-Che\|Chen, Peini\|Guh, Jih-Hwa
PMID:	21840189

70.
Journal:	Cancer Epidemiol. 2012 Apr;36(2):206-11.
Title:	Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.
Author:	Dong, Xiaoqun\|Li, Yanan\|Tang, Hongwei\|Chang, Ping\|Hess, Kenneth R\|Abbruzzese, James L\|Li, Donghui
PMID:	21852217

71.
Journal:	Biotechnol Adv. 2012 Jan-Feb;30(1):169-84.
Title:	The PPAR-gamma agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-beta treated pancreatic cancer cells.
Author:	Vitale, Giovanni\|Zappavigna, Silvia\|Marra, Monica\|Dicitore, Alessandra\|Meschini, Stefania\|Condello, Maria\|Arancia, Giuseppe\|Castiglioni, Sara\|Maroni, Paola\|Bendinelli, Paola\|Piccoletti, Roberta\|van Koetsveld, Peter M\|Cavagnini, Francesco\|Budillon, Alfredo
PMID:	21871555

72.
Journal:	J Cell Biochem. 2012 Mar;113(3):784-91.
Title:	The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer.
Author:	Awasthi, Niranjan\|Yen, Peter L\|Schwarz, Margaret A\|Schwarz, Roderich E
PMID:	22020918

73.
Journal:	Methods Mol Biol. 2012;821:187-214.
Title:	A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation.
Author:	Papageorgiou, Angela\|Avruch, Joseph
PMID:	22125066

74.
Journal:	Oncol Rep. 2012 Mar;27(3):891-7.
Title:	Cucurmosin induces apoptosis of BxPC-3 human pancreatic cancer cells via inactivation of the EGFR signaling pathway.
Author:	Zhang, Baoming\|Huang, Heguang\|Xie, Jieming\|Xu, Chunsen\|Chen, Minghuang\|Wang, Congfei\|Yang, Aiqin\|Yin, Qiang
PMID:	22139427

75.
Journal:	Tumour Biol. 2012 Jun;33(3):757-65.
Title:	The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines.
Author:	Glienke, Wolfgang\|Maute, Luise\|Wicht, Johannes\|Bergmann, Lothar
PMID:	22170433

76.
Journal:	Am J Surg Pathol. 2012 Jan;36(1):149-53.
Title:	Well-differentiated pancreatic neuroendocrine carcinoma in tuberous sclerosis--case report and review of the literature.
Author:	Arva, Nicoleta C\|Pappas, John G\|Bhatla, Teena\|Raetz, Elizabeth A\|Macari, Michael\|Ginsburg, Howard B\|Hajdu, Cristina H
PMID:	22173120

77.
Journal:	Curr Treat Options Oncol. 2012 Mar;13(1):24-34.
Title:	Neuroendocrine pancreatic tumors: guidelines for management and update.
Author:	Burns, William R\|Edil, Barish H
PMID:	22198808

78.
Journal:	Int J Biol Sci. 2012;8(1):1-14. Epub 2011 Nov 5.
Title:	Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway.
Author:	Wei, Wei-Tian\|Chen, Hui\|Wang, Zhao-Hong\|Ni, Zhong-Lin\|Liu, Hai-Bin\|Tong, Hong-Fei\|Guo, Hong-Chun\|Liu, Dian-Lei\|Lin, Sheng-Zhang
PMID:	22211100

79.
Journal:	JOP. 2012 Mar 10;13(2):159-62.
Title:	First-line treatment of metastatic pancreatic cancer.
Author:	Tokh, Mohammed\|Bathini, Venu\|Saif, Muhammad Wasif
PMID:	22406590

80.
Journal:	JOP. 2012 Mar 10;13(2):169-73.
Title:	Pancreatic neuroendocrine tumors: entering a new era.
Author:	Oberstein, Paul E\|Remotti, Helen\|Saif, Muhammad Wasif\|Libutti, Steven K
PMID:	22406593

81.
Journal:	Curr Opin Oncol. 2012 Jul;24(4):433-40.
Title:	Neuroendocrine tumors of the digestive tract: impact of new classifications and new agents on therapeutic approaches.
Author:	Oberg, Kjell
PMID:	22510940

82.
Journal:	Mol Cancer Ther. 2012 Jul;11(7):1598-608.
Title:	CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis.
Author:	Subramaniam, Dharmalingam\|Periyasamy, Giridharan\|Ponnurangam, Sivapriya\|Chakrabarti, Debarshi\|Sugumar, Aravind\|Padigaru, Muralidhara\|Weir, Scott J\|Balakrishnan, Arun\|Sharma, Somesh\|Anant, Shrikant
PMID:	22532602

83.
Journal:	PLoS One. 2012;7(5):e36252.
Title:	FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer.
Author:	Hou, Junmei\|Wang, Liewei
PMID:	22590527

84.
Journal:	J Surg Res. 2012 Dec;178(2):758-67.
Title:	Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells.
Author:	Kagawa, Shingo\|Takano, Shigetsugu\|Yoshitomi, Hideyuki\|Kimura, Fumio\|Satoh, Mamoru\|Shimizu, Hiroaki\|Yoshidome, Hiroyuki\|Ohtsuka, Masayuki\|Kato, Atsushi\|Furukawa, Katsunori\|Matsushita, Kazuyuki\|Nomura, Fumio\|Miyazaki, Masaru
PMID:	22726648

85.
Journal:	Genome Med. 2012 Jul 4;4(7):56.
Title:	Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability.
Author:	Demeure, Michael J\|Craig, David W\|Sinari, Shripad\|Moses, Tracy M\|Christoforides, Alexis\|Dinh, Jennifer\|Izatt, Tyler\|Aldrich, Jessica\|Decker, Ardis\|Baker, Angela\|Cherni, Irene\|Watanabe, April\|Koep, Lawrence\|Lake, Douglas\|Hostetter, Galen\|Trent, Jeffrey M\|V
PMID:	22762308

86.
Journal:	Oncology. 2012;83(3):117-27.
Title:	Current status and perspectives of targeted therapy in well-differentiated neuroendocrine tumors.
Author:	Naraev, Boris G\|Strosberg, Jonathan R\|Halfdanarson, Thorvardur R
PMID:	22797357

87.
Journal:	JOP. 2012 Jul 10;13(4):368-71.
Title:	Update on prognostic and predictive biomarkers for pancreatic neuroendocrine tumors.
Author:	Oberstein, Paul Eliezer\|Saif, Muhammad Wasif
PMID:	22797391

88.
Journal:	Onco Targets Ther. 2012;5:217-24.
Title:	Treatment of advanced pancreatic neuroendocrine tumors: potential role of everolimus.
Author:	Cen, Putao\|Amato, Robert J
PMID:	22870038

89.
Journal:	Target Oncol. 2012 Sep;7(3):173-81.
Title:	Resistance to targeted therapies in pancreatic neuroendocrine tumors (PNETs): molecular basis, preclinical data, and counteracting strategies.
Author:	Tijeras-Raballand, Annemilai\|Neuzillet, Cindy\|Couvelard, Anne\|Serova, Maria\|de Gramont, Armand\|Hammel, Pascal\|Raymond, Eric\|Faivre, Sandrine
PMID:	22923165

90.
Journal:	J Gastrointest Oncol. 2012 Sep;3(3):182-8.
Title:	Molecular pathology of pancreatic neuroendocrine tumors.
Author:	Chen, Mingyi\|Van Ness, Michael\|Guo, Yangtong\|Gregg, Jeffrey
PMID:	22943010

91.
Journal:	J Exp Ther Oncol. 2012;10(1):51-64.
Title:	Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent.
Author:	Deeb, Dorrah\|Gao, Xiaohua\|Liu, Yong Bo\|Gautam, Subhash C
PMID:	22946344

92.
Journal:	Int J Clin Exp Pathol. 2012;5(6):537-46. Epub 2012 Jul 29.
Title:	Analysis of whole genomic expression profiles and screening of the key signaling pathways associated with pancreatic cancer.
Author:	He, Chengzhi\|Jiang, Hua\|Geng, Shasha\|Sheng, Haihui\|Shen, Xiaoying\|Zhang, Xiaoyan\|Zhu, Shizhang\|Chen, Ximei\|Yang, Changqing\|Gao, Hengjun
PMID:	22949936

93.
Journal:	Neoplasia. 2012 Aug;14(8):690-701.
Title:	Stromal cell-derived factor 1alpha mediates resistance to mTOR-directed therapy in pancreatic cancer.
Author:	Weekes, Colin D\|Song, Dongweon\|Arcaroli, John\|Wilson, Lora A\|Rubio-Viqueira, Belen\|Cusatis, George\|Garrett-Mayer, Elizabeth\|Messersmith, Wells A\|Winn, Robert A\|Hidalgo, Manuel
PMID:	22952422

94.
Journal:	Cancer Res. 2012 Nov 15;72(22):5683-91.
Title:	The FGFR4-G388R single-nucleotide polymorphism alters pancreatic neuroendocrine tumor progression and response to mTOR inhibition therapy.
Author:	Serra, Stefano\|Zheng, Lei\|Hassan, Manal\|Phan, Alexandria T\|Woodhouse, Linda J\|Yao, James C\|Ezzat, Shereen\|Asa, Sylvia L
PMID:	22986737

95.
Journal:	J Endocrinol Invest. 2012 Nov;35(10):930-6.
Title:	New drugs in the therapy of neuroendocrine tumors.
Author:	Grozinsky-Glasberg, S\|Gross, D J
PMID:	23047256

96.
Journal:	Turk J Gastroenterol. 2012;23(5):427-37.
Title:	Systemic treatment of neuroendocrine tumors with hepatic metastases.
Author:	Demirkan, Binnaz H M\|Eriksson, Barbro
PMID:	23161287

97.
Journal:	Oncol Lett. 2012 Oct;4(4):588-594.
Title:	The role of AIB1 in breast cancer.
Author:	Chang, Alan K\|Wu, Huijian
PMID:	23226788

98.
Journal:	Oncotarget. 2012 Nov;3(11):1416-27.
Title:	Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer.
Author:	Venkannagari, Sreedhar\|Fiskus, Warren\|Peth, Karissa\|Atadja, Peter\|Hidalgo, Manuel\|Maitra, Anirban\|Bhalla, Kapil N
PMID:	23232026

99.
Journal:	Int J Mol Sci. 2012 Dec 21;14(1):273-85.
Title:	Antitumor effects of rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy.
Author:	Dai, Zhi-Jun\|Gao, Jie\|Ma, Xiao-Bin\|Kang, Hua-Feng\|Wang, Bao-Feng\|Lu, Wang-Feng\|Lin, Shuai\|Wang, Xi-Jing\|Wu, Wen-Ying
PMID:	23344033

100.
Journal:	Invest New Drugs. 2013 Feb;31(1):85-91.
Title:	A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer.
Author:	Kordes, Sil\|Richel, Dick J\|Klumpen, Heinz-Josef\|Weterman, Mariette J\|Stevens, Arnoldus J W M\|Wilmink, Johanna W
PMID:	22367239

101.
Journal:	Neuroendocrinology. 2013;97(1):99-112.
Title:	Translation of molecular pathways into clinical trials of neuroendocrine tumors.
Author:	Pavel, Marianne
PMID:	22508344

102.
Journal:	Anticancer Agents Med Chem. 2013 Mar;13(3):382-8.
Title:	Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy.
Author:	Leung, Roland\|Lang, Brian\|Wong, Hilda\|Chiu, Joanne\|Yat, Wan K\|Shek, Tony\|Cho, Woo Y\|Yau, Lo C\|Yau, Thomas
PMID:	23092266

103.
Journal:	Cancer Res. 2013 Jan 1;73(1):12-8.
Title:	mTOR inhibitor RAD001 promotes metastasis in a rat model of pancreatic neuroendocrine cancer.
Author:	Pool, Stefan E\|Bison, Sander\|Koelewijn, Stuart J\|van der Graaf, Linda M\|Melis, Marleen\|Krenning, Eric P\|de Jong, Marion
PMID:	23149918

104.
Journal:	Anticancer Agents Med Chem. 2013 Jul 1;13(6):952-6.
Title:	Cucurmosin kills human pancreatic cancer SW-1990 cells in vitro and in vivo.
Author:	Xie, Jieming\|Wang, Congfei\|Yang, Aiqin\|Zhang, Baoming\|Yin, Qiang\|Huang, Heguang\|Chen, Minghuang
PMID:	23157594

105.
Journal:	Pancreas. 2013 Apr;42(3):411-21.
Title:	Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors.
Author:	Gilbert, Judith A\|Adhikari, Laura J\|Lloyd, Ricardo V\|Halfdanarson, Thorvardur R\|Muders, Michael H\|Ames, Matthew M
PMID:	23211371

106.
Journal:	Apoptosis. 2013 Mar;18(3):337-46.
Title:	Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.
Author:	Fiorini, Claudia\|Menegazzi, Marta\|Padroni, Chiara\|Dando, Ilaria\|Dalla Pozza, Elisa\|Gregorelli, Alex\|Costanzo, Chiara\|Palmieri, Marta\|Donadelli, Massimo
PMID:	23238993

107.
Journal:	Exp Ther Med. 2013 Jan;5(1):338-342.
Title:	Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus.
Author:	Liu, Ling\|Gong, Liansheng\|Zhang, Yangde\|Li, Nianfeng
PMID:	23251295

108.
Journal:	Hum Pathol. 2013 Jun;44(6):1024-30.
Title:	Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma.
Author:	Foo, Wai Chin\|Rashid, Asif\|Wang, Hua\|Katz, Matthew H\|Lee, Jeffrey E\|Pisters, Peter W\|Wolff, Robert A\|Abbruzzese, James L\|Fleming, Jason B\|Wang, Huamin
PMID:	23260327

109.
Journal:	Curr Mol Med. 2013 Mar;13(3):333-9.
Title:	Pancreatic neuroendocrine tumors: signal pathways and targeted therapies.
Author:	Peng, L\|Schwarz, R E
PMID:	23331005

110.
Journal:	Cancer Res. 2013 Mar 15;73(6):1811-20.
Title:	Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer.
Author:	Khalaileh, Abed\|Dreazen, Avigail\|Khatib, Areej\|Apel, Roy\|Swisa, Avital\|Kidess-Bassir, Norma\|Maitra, Anirban\|Meyuhas, Oded\|Dor, Yuval\|Zamir, Gideon
PMID:	23361300

111.
Journal:	PLoS One. 2013;8(2):e57289.
Title:	Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.
Author:	Soares, Heloisa P\|Ni, Yang\|Kisfalvi, Krisztina\|Sinnett-Smith, James\|Rozengurt, Enrique
PMID:	23437362

112.
Journal:	Mol Cancer Res. 2013 May;11(5):474-81.
Title:	Suppression of AKT phosphorylation restores rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells.
Author:	Le Gendre, Onica\|Sookdeo, Ayisha\|Duliepre, Stephie-Anne\|Utter, Matthew\|Frias, Maria\|Foster, David A
PMID:	23443316

113.
Journal:	Clin Cancer Res. 2013 Apr 15;19(8):2025-35.
Title:	Targeting the NF-kappaB and mTOR pathways with a quinoxaline urea analog that inhibits IKKbeta for pancreas cancer therapy.
Author:	Radhakrishnan, Prakash\|Bryant, Vashti C\|Blowers, Elizabeth C\|Rajule, Rajkumar N\|Gautam, Nagsen\|Anwar, Muhammad M\|Mohr, Ashley M\|Grandgenett, Paul M\|Bunt, Stephanie K\|Arnst, Jamie L\|Lele, Subodh M\|Alnouti, Yazen\|Hollingsworth, Michael A\|Natarajan, Amarnath
PMID:	23444213

114.
Journal:	Onco Targets Ther. 2013;6:95-7.
Title:	Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion?
Author:	Gazzah, Anas\|Gonzales, Daniel Barrios\|Levy, Antonin\|Bahleda, Rastislav\|Ducreux, Michel\|Lacroix, Ludovic\|Soria, Jean Charles
PMID:	23450148

115.
Journal:	Cancer Chemother Pharmacol. 2013 May;71(5):1231-40.
Title:	Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice.
Author:	Pawaskar, Dipti K\|Straubinger, Robert M\|Fetterly, Gerald J\|Hylander, Bonnie H\|Repasky, Elizabeth A\|Ma, Wen W\|Jusko, William J
PMID:	23455452

116.
Journal:	Oncotarget. 2013 Feb;4(2):277-88.
Title:	Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models.
Author:	Diersch, Sandra\|Wenzel, Patrick\|Szameitat, Melanie\|Eser, Philipp\|Paul, Mariel C\|Seidler, Barbara\|Eser, Stefan\|Messer, Marlena\|Reichert, Maximilian\|Pagel, Philipp\|Esposito, Irene\|Schmid, Roland M\|Saur, Dieter\|Schneider, Gunter
PMID:	23470560

117.
Journal:	Hered Cancer Clin Pract. 2013 Apr 1;11(1):2.
Title:	Systemic treatment for hereditary cancers: a 2012 update.
Author:	Imyanitov, Evgeny N\|Byrski, Tomasz
PMID:	23548133

118.
Journal:	Chin J Cancer. 2013 May;32(5):253-65.
Title:	Targeting the PI3K-AKT-mTOR signaling network in cancer.
Author:	Khan, Khurum H\|Yap, Timothy A\|Yan, Li\|Cunningham, David
PMID:	23642907

119.
Journal:	Ann N Y Acad Sci. 2013 Jul;1291:14-32.
Title:	Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases.
Author:	Lebwohl, David\|Anak, Ozlem\|Sahmoud, Tarek\|Klimovsky, Judith\|Elmroth, Ingrid\|Haas, Tomas\|Posluszny, Joseph\|Saletan, Stephen\|Berg, William
PMID:	23659703

120.
Journal:	Drug Des Devel Ther. 2013 Mar 19;7:149-59.
Title:	Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells.
Author:	Dai, Zhi-Jun\|Gao, Jie\|Kang, Hua-Feng\|Ma, Yu-Guang\|Ma, Xiao-Bin\|Lu, Wang-Feng\|Lin, Shuai\|Ma, Hong-Bing\|Wang, Xi-Jing\|Wu, Wen-Ying
PMID:	23662044

121.
Journal:	PLoS One. 2013 May 8;8(5):e63969.
Title:	Low concentrations of metformin selectively inhibit CD133(+) cell proliferation in pancreatic cancer and have anticancer action.
Author:	Gou, Shanmiao\|Cui, Pengfei\|Li, Xiangsheng\|Shi, Pengfei\|Liu, Tao\|Wang, Chunyou
PMID:	23667692

122.
Journal:	Onkologie. 2013;36(5):295-302.
Title:	Practical management of everolimus-related toxicities in patients with advanced solid tumors.
Author:	Grunwald, Viktor\|Weikert, Steffen\|Pavel, Marianne E\|Horsch, Dieter\|Luftner, Diana\|Janni, Wolfgang\|Geberth, Matthias\|Weber, Matthias M
PMID:	23689226

123.
Journal:	Am J Chin Med. 2013;41(3):629-42.
Title:	PI3K/AKT/mTOR signaling is involved in (-)-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells.
Author:	Liu, Shi\|Wang, Xiao-Jie\|Liu, Ying\|Cui, Yun-Fu
PMID:	23711146

124.
Journal:	Ann Pharmacother. 2013 Jul-Aug;47(7-8):1055-63.
Title:	Drug interactions and the pharmacist: focus on everolimus.
Author:	Grabowsky, Jennifer A
PMID:	23757385

125.
Journal:	PLoS One. 2013 Jun 18;8(6):e66371.
Title:	Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts.
Author:	Hermann, Patrick C\|Trabulo, Sara M\|Sainz, Bruno Jr\|Balic, Anamaria\|Garcia, Elena\|Hahn, Stephan A\|Vandana, Mallaredy\|Sahoo, Sanjeeb K\|Tunici, Patrizia\|Bakker, Annette\|Hidalgo, Manuel\|Heeschen, Christopher
PMID:	23825539

126.
Journal:	Curr Drug Targets. 2013 Sep;14(10):1110-7.
Title:	miRNAs in insulin resistance and diabetes-associated pancreatic cancer: the 'minute and miracle' molecule moving as a monitor in the 'genomic galaxy'.
Author:	Chakraborty, Chiranjib\|George Priya Doss, C\|Bandyopadhyay, Sanghamitra
PMID:	23834149

127.
Journal:	J Natl Cancer Inst. 2013 Jul 17;105(14):1005-17.
Title:	Current understanding of the molecular biology of pancreatic neuroendocrine tumors.
Author:	Zhang, Jianliang\|Francois, Rony\|Iyer, Renuka\|Seshadri, Mukund\|Zajac-Kaye, Maria\|Hochwald, Steven N
PMID:	23840053

128.
Journal:	Biochim Biophys Acta. 2013 Dec;1833(12):2856-65.
Title:	Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy.
Author:	Pelizzaro-Rocha, Karin Juliane\|de Jesus, Marcelo Bispo\|Ruela-de-Sousa, Roberta Regina\|Nakamura, Celso Vataru\|Reis, Fabiano Souza\|de Fatima, Angelo\|Ferreira-Halder, Carmen Verissima
PMID:	23872419

129.
Journal:	Mol Cancer. 2013 Jul 25;12:81.
Title:	miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer.
Author:	Wei, Feng\|Liu, Yan\|Guo, Yanhai\|Xiang, An\|Wang, Guangyi\|Xue, Xiaochang\|Lu, Zifan
PMID:	23886294

130.
Journal:	Pharmacol Rep. 2013;65(3):682-8.
Title:	Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-beta signalling pathway.
Author:	Xie, Jieming\|Wang, Congfei\|Zhang, Baoming\|Yang, Aiqin\|Yin, Qiang\|Huang, Heguang\|Chen, Minghuang
PMID:	23950591

131.
Journal:	Cancer Prev Res (Phila). 2013 Oct;6(10):1046-55.
Title:	Dietary energy balance modulation of Kras- and Ink4a/Arf+/--driven pancreatic cancer: the role of insulin-like growth factor-I.
Author:	Lashinger, Laura M\|Harrison, Lauren M\|Rasmussen, Audrey J\|Logsdon, Craig D\|Fischer, Susan M\|McArthur, Mark J\|Hursting, Stephen D
PMID:	23980075

132.
Journal:	Therap Adv Gastroenterol. 2013 Sep;6(5):412-9.
Title:	Everolimus in the treatment of patients with advanced pancreatic neuroendocrine tumors: latest findings and interpretations.
Author:	Liu, Eric\|Marincola, Paula\|Oberg, Kjell
PMID:	24003341

133.
Journal:	Case Rep Oncol. 2013 Aug 24;6(2):441-9.
Title:	Prolonged clinical benefit of everolimus therapy in the management of high-grade pancreatic neuroendocrine carcinoma.
Author:	Fonseca, Paula J\|Uriol, Esther\|Galvan, Jose A\|Alvarez, Carlos\|Perez, Quionia\|Villanueva, Noemi\|Berros, Jose P\|Izquierdo, Marta\|Vieitez, Jose M
PMID:	24019785

134.
Journal:	PLoS One. 2013 Oct 18;8(10):e76518.
Title:	Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells.
Author:	Lonardo, Enza\|Cioffi, Michele\|Sancho, Patricia\|Sanchez-Ripoll, Yolanda\|Trabulo, Sara Maria\|Dorado, Jorge\|Balic, Anamaria\|Hidalgo, Manuel\|Heeschen, Christopher
PMID:	24204632

135.
Journal:	PLoS One. 2013 Oct 31;8(10):e78632.
Title:	Lysophosphatidic acid acyltransferase beta regulates mTOR signaling.
Author:	Blaskovich, Michelle A\|Yendluri, Vimala\|Lawrence, Harshani R\|Lawrence, Nicholas J\|Sebti, Said M\|Springett, Gregory M
PMID:	24205284

136.
Journal:	Cell Rep. 2013 Oct 31;5(2):314-22.
Title:	PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis.
Author:	Jun, Sohee\|Lee, Sunhye\|Kim, Han-Cheon\|Ng, Christopher\|Schneider, Andrea M\|Ji, Hong\|Ying, Haoqiang\|Wang, Huamin\|DePinho, Ronald A\|Park, Jae-Il
PMID:	24209743

137.
Journal:	Sci Rep. 2013 Nov 15;3:3230.
Title:	mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions.
Author:	Matsubara, Shyuichiro\|Ding, Qiang\|Miyazaki, Yumi\|Kuwahata, Taisaku\|Tsukasa, Koichiro\|Takao, Sonshin
PMID:	24231729

138.
Journal:	Transl Oncol. 2013 Dec 1;6(6):649-59. eCollection 2013 Dec 1.
Title:	Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling.
Author:	Mohammed, Altaf\|Janakiram, Naveena B\|Brewer, Misty\|Ritchie, Rebekah L\|Marya, Anuj\|Lightfoot, Stan\|Steele, Vernon E\|Rao, Chinthalapally V
PMID:	24466367

139.
Journal:	Hepatogastroenterology. 2013 Oct;60(127):1766-72.
Title:	PTEN/PI3K/mTOR/B7-H1 signaling pathway regulates cell progression and immuno-resistance in pancreatic cancer.
Author:	Zhang, Yingfei\|Zhang, Jianlong\|Xu, Kang\|Xiao, Zhiyu\|Sun, Jian\|Xu, Junyao\|Wang, Jie\|Tang, Qibing
PMID:	24624456

140.
Journal:	Am J Clin Oncol. 2014 Jun;37(3):266-71.
Title:	Rash to the mTOR inhibitor everolimus: systematic review and meta-analysis.
Author:	Ramirez-Fort, Marigdalia K\|Case, Emily C\|Rosen, Alyx C\|Cerci, Felipe B\|Wu, Shenhong\|Lacouture, Mario E
PMID:	23241507

141.
Journal:	Mol Carcinog. 2014 Sep;53(9):722-35.
Title:	Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo.
Author:	Chien, Wenwen\|Lee, Dhong Hyun\|Zheng, Yun\|Wuensche, Peer\|Alvarez, Rosie\|Wen, Ding Ling\|Aribi, Ahmed M\|Thean, Su Ming\|Doan, Ngan B\|Said, Jonathan W\|Koeffler, H Phillip
PMID:	23475695

142.
Journal:	Oncogene. 2014 Mar 13;33(11):1367-74.
Title:	Pancreatic tumours escape from translational control through 4E-BP1 loss.
Author:	Martineau, Y\|Azar, R\|Muller, D\|Lasfargues, C\|El Khawand, S\|Anesia, R\|Pelletier, J\|Bousquet, C\|Pyronnet, S
PMID:	23563181

143.
Journal:	Clin Cancer Res. 2014 Jan 1;20(1):110-9.
Title:	The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.
Author:	Hayman, Thomas J\|Wahba, Amy\|Rath, Barbara H\|Bae, Heekyong\|Kramp, Tamalee\|Shankavaram, Uma T\|Camphausen, Kevin\|Tofilon, Philip J
PMID:	24198241

144.
Journal:	Mol Cancer Ther. 2014 Jan;13(1):37-48.
Title:	Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells.
Author:	Zeng, Jun-Ying\|Sharma, Sharad\|Zhou, Yong-Qing\|Yao, Hang-Ping\|Hu, Xing\|Zhang, Ruiwen\|Wang, Ming-Hai
PMID:	24233399

145.
Journal:	Cancer Metastasis Rev. 2014 Mar;33(1):367-72.
Title:	Systemic therapeutic strategies for GEP-NETS: what can we expect in the future?
Author:	Raymond, E\|Garcia-Carbonero, R\|Wiedenmann, B\|Grande, E\|Pavel, M
PMID:	24375390

146.
Journal:	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jan;30(1):23-7.
Title:	[Mechanism underlying pancreatic cancer cell resistance to mTOR inhibitor RAD001 via c-Raf/ERK1/2 activation].
Author:	Wei, Feng\|Zhang, Ping\|Qi, Jun\|Wang, Meng\|Wang, Guangyi
PMID:	24405594

147.
Journal:	Acta Histochem. 2014 Jun;116(5):723-9.
Title:	Antagonism of microRNA-99a promotes cell invasion and down-regulates E-cadherin expression in pancreatic cancer cells by regulating mammalian target of rapamycin.
Author:	Li, Dan\|Li, Xiaohan\|Cao, Wei\|Qi, Yafei\|Yang, Xianghong
PMID:	24461517

148.
Journal:	Cancer Lett. 2014 May 1;346(2):309-17.
Title:	mTOR is a promising therapeutical target in a subpopulation of pancreatic adenocarcinoma.
Author:	Utomo, Wesley K\|Narayanan, Vilvapathy\|Biermann, Katharina\|van Eijck, Casper H J\|Bruno, Marco J\|Peppelenbosch, Maikel P\|Braat, Henri
PMID:	24467966

149.
Journal:	PLoS One. 2014 Feb 5;9(2):e87868.
Title:	Antitumor efficacy of alpha-solanine against pancreatic cancer in vitro and in vivo.
Author:	Lv, Chongqing\|Kong, Hongru\|Dong, Guohua\|Liu, Lewei\|Tong, Kun\|Sun, Hongwei\|Chen, Bicheng\|Zhang, Chunwu\|Zhou, Mengtao
PMID:	24505326

150.
Journal:	PLoS One. 2014 Feb 5;9(2):e87979.
Title:	Response of breast cancer cells and cancer stem cells to metformin and hyperthermia alone or combined.
Author:	Lee, Hyemi\|Park, Heon Joo\|Park, Chang-Shin\|Oh, Eun-Taex\|Choi, Bo-Hwa\|Williams, Brent\|Lee, Chung K\|Song, Chang W
PMID:	24505341

151.
Journal:	Anticancer Res. 2014 Feb;34(2):631-7.
Title:	Role of autophagy in apoptotic regulation by Akt in pancreatic cancer.
Author:	Muilenburg, Diego\|Parsons, Colin\|Coates, Jodi\|Virudachalam, Subbulakshmi\|Bold, Richard J
PMID:	24510992

152.
Journal:	Cancer Prev Res (Phila). 2014 Apr;7(4):388-97.
Title:	Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment.
Author:	Yue, Wen\|Yang, Chung S\|DiPaola, Robert S\|Tan, Xiang-Lin
PMID:	24520038

153.
Journal:	Carcinogenesis. 2014 Sep;35(9):1968-76.
Title:	Mirk/dyrk1B kinase is upregulated following inhibition of mTOR.
Author:	Deng, Xiaobing\|Hu, Jing\|Ewton, Daina Z\|Friedman, Eileen
PMID:	24590896

154.
Journal:	Int J Oncol. 2014 May;44(5):1707-15.
Title:	Pristimerin, a quinonemethide triterpenoid, induces apoptosis in pancreatic cancer cells through the inhibition of pro-survival Akt/NF-kappaB/mTOR signaling proteins and anti-apoptotic Bcl-2.
Author:	Deeb, Dorrah\|Gao, Xiaohua\|Liu, Yong Bo\|Pindolia, Kirit\|Gautam, Subhash C
PMID:	24603988

155.
Journal:	Ann Oncol. 2014 Apr;25(4):763-73.
Title:	Adverse event management in patients with advanced cancer receiving oral everolimus: focus on breast cancer.
Author:	Aapro, M\|Andre, F\|Blackwell, K\|Calvo, E\|Jahanzeb, M\|Papazisis, K\|Porta, C\|Pritchard, K\|Ravaud, A
PMID:	24667713

156.
Journal:	Cell Commun Signal. 2014 Mar 26;12:20.
Title:	Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFbeta1.
Author:	Basso, Daniela\|Bozzato, Dania\|Padoan, Andrea\|Moz, Stefania\|Zambon, Carlo-Federico\|Fogar, Paola\|Greco, Eliana\|Scorzeto, Michele\|Simonato, Francesca\|Navaglia, Filippo\|Fassan, Matteo\|Pelloso, Michela\|Dupont, Sirio\|Pedrazzoli, Sergio\|Fassina, Ambrogio\|Plebani
PMID:	24670043

157.
Journal:	Tumori. 2014 Jan-Feb;100(1):e2-3.
Title:	Everolimus in advanced solid tumors: when to start, early or late?
Author:	Pusceddu, Sara\|Tessari, Anna\|Testa, Isabella\|Procopio, Giuseppe
PMID:	24675508

158.
Journal:	Cancer Metab. 2014 Mar 31;2(1):6.
Title:	Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice.
Author:	Liu, Kristyn A\|Lashinger, Laura M\|Rasmussen, Audrey J\|Hursting, Stephen D
PMID:	24685128

159.
Journal:	Int J Clin Exp Pathol. 2014 Feb 15;7(3):923-31. eCollection 2014.
Title:	Downregulation of mTOR by lentivirus inhibits prostate cancer cell growth.
Author:	Du, Yue-Feng\|Long, Qing-Zhi\|Shi, Ying\|Liu, Xiao-Gang\|Li, Xu-Dong\|Zeng, Jin\|Gong, Yong-Guang\|Wang, Xin-Yang\|He, Da-Lin
PMID:	24695460

160.
Journal:	Gut. 2014 Sep;63(9):1481-9.
Title:	Targeting mTOR dependency in pancreatic cancer.
Author:	Morran, Douglas C\|Wu, Jianmin\|Jamieson, Nigel B\|Mrowinska, Agata\|Kalna, Gabriela\|Karim, Saadia A\|Au, Amy Y M\|Scarlett, Christopher J\|Chang, David K\|Pajak, Malgorzata Z\|Oien, Karin A\|McKay, Colin J\|Carter, C Ross\|Gillen, Gerry\|Champion, Sue\|Pimlott, Sally
PMID:	24717934

161.
Journal:	Int J Oncol. 2014 Jul;45(1):311-21.
Title:	HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer.
Author:	Jung, Kyung Hee\|Yan, Hong Hua\|Fang, Zhenghuan\|Son, Mi Kwon\|Lee, Hyunseung\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	24819705

162.
Journal:	J Biol Chem. 2014 Aug 1;289(31):21694-705.
Title:	The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
Author:	Duan, Lei\|Ying, Guoguang\|Danzer, Brian\|Perez, Ricardo E\|Shariat-Madar, Zia\|Levenson, Victor V\|Maki, Carl G
PMID:	24936056

163.
Journal:	Oncol Lett. 2014 Apr;7(4):1165-1168.
Title:	BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition.
Author:	Legendre, Onica\|Sookdeo, Ayisha\|Foster, David A
PMID:	24944686

164.
Journal:	Biochem Biophys Res Commun. 2014 Jul 25;450(2):973-8.
Title:	The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells.
Author:	Lou, Hai-Zhou\|Weng, Xiao-Chuan\|Pan, Hong-Ming\|Pan, Qin\|Sun, Peng\|Liu, Li-Li\|Chen, Bin
PMID:	24971544

165.
Journal:	BMC Complement Altern Med. 2014 Jul 8;14:228.
Title:	Antitumor effect of Kanglaite(R) injection in human pancreatic cancer xenografts.
Author:	Liu, Ying\|Zhang, Wei\|Wang, Xiao-Jie\|Liu, Shi
PMID:	25005526

166.
Journal:	Anticancer Drugs. 2014 Oct;25(9):1095-101.
Title:	Combination of antiangiogenic therapy using the mTOR-inhibitor everolimus and low-dose chemotherapy for locally advanced and/or metastatic pancreatic cancer: a dose-finding study.
Author:	Joka, Mareile\|Boeck, Stefan\|Zech, Christoph J\|Seufferlein, Thomas\|Wichert, Goetz von\|Licht, Thomas\|Krause, Annekatrin\|Jauch, Karl-Walter\|Heinemann, Volker\|Bruns, Christiane J
PMID:	25029236

167.
Journal:	Arch Pathol Lab Med. 2014 Aug;138(8):1027-36.
Title:	Progesterone receptor and PTEN expression predict survival in patients with low- and intermediate-grade pancreatic neuroendocrine tumors.
Author:	Estrella, Jeannelyn S\|Broaddus, Russell R\|Mathews, Amber\|Milton, Denai R\|Yao, James C\|Wang, Huamin\|Rashid, Asif
PMID:	25076292

168.
Journal:	JOP. 2014 Jul 28;15(4):313-6.
Title:	Chemotherapy and metformin in pancreatic adenocarcinoma and neuroendocrine tumors.
Author:	Burney, Saira\|Khawaja, Khadija Irfan\|Saif, Muhammad Wasif\|Masud, Faisal
PMID:	25076330

169.
Journal:	J Biol Chem. 2014 Oct 3;289(40):27692-701.
Title:	Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors.
Author:	Nair, Vijayalekshmi\|Sreevalsan, Sandeep\|Basha, Riyaz\|Abdelrahim, Maen\|Abudayyeh, Ala\|Rodrigues Hoffman, Aline\|Safe, Stephen
PMID:	25143389

170.
Journal:	Biochem Biophys Res Commun. 2014 Sep 12;452(1):106-11.
Title:	DNA-PKcs is important for Akt activation and gemcitabine resistance in PANC-1 pancreatic cancer cells.
Author:	Hu, Hao\|Gu, Yuanlong\|Qian, Yi\|Hu, Benshun\|Zhu, Congyuan\|Wang, Gaohe\|Li, Jianping
PMID:	25152407

171.
Journal:	Oncotarget. 2014 Aug 15;5(15):6512-25.
Title:	CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer.
Author:	Franco, Jorge\|Witkiewicz, Agnieszka K\|Knudsen, Erik S
PMID:	25156567

172.
Journal:	Eur Rev Med Pharmacol Sci. 2014;18(17):2482-90.
Title:	Identifying significant crosstalk of pathways in tuberous sclerosis complex.
Author:	Zhang, B-L\|Wang, L-J\|Sun, L\|Zhang, H-L\|Wu, X-M\|Sun, Y\|Deng, F\|Zhang, Y\|Cheng, Y-Y\|Feng, J-C
PMID:	25268093

173.
Journal:	Cancer Treat Rev. 2014 Dec;40(10):1230-8.
Title:	Practical management of sunitinib toxicities in the treatment of pancreatic neuroendocrine tumors.
Author:	Valle, Juan W\|Faivre, Sandrine\|Hubner, Richard A\|Grande, Enrique\|Raymond, Eric
PMID:	25283354

174.
Journal:	Biochem Biophys Res Commun. 2014 Oct 24;453(3):533-8.
Title:	GDC-0980-induced apoptosis is enhanced by autophagy inhibition in human pancreatic cancer cells.
Author:	Tang, Jian-Ying\|Dai, Tu\|Zhang, Hui\|Xiong, Wu-Jun\|Xu, Ming-Zheng\|Wang, Xu-Jing\|Tang, Qing-He\|Chen, Bo\|Xu, Ming
PMID:	25285629

175.
Journal:	Front Physiol. 2014 Sep 23;5:357.
Title:	Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells.
Author:	Rozengurt, Enrique
PMID:	25295009

176.
Journal:	Endocr Pract. 2014 Nov;20(11):1222-30.
Title:	Advances in diagnosis and treatment of pancreatic neuroendocrine tumors.
Author:	Vinik, Aaron I
PMID:	25297671

177.
Journal:	Oncol Rep. 2014 Dec;32(6):2753-9.
Title:	Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors.
Author:	Sato, Shoki\|Tsuchikawa, Takahiro\|Nakamura, Toru\|Sato, Nagato\|Tamoto, Eiji\|Okamura, Keisuke\|Shichinohe, Toshiaki\|Hirano, Satoshi
PMID:	25310565

178.
Journal:	Genes Cancer. 2014 Sep;5(9-10):337-47.
Title:	Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells.
Author:	Deng, Xiaobing\|Friedman, Eileen
PMID:	25352950

179.
Journal:	Neoplasia. 2014 Nov 20;16(11):909-17.
Title:	Neurogenin 3-directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma.
Author:	Ding, Li\|Han, Lingling\|Li, Yin\|Zhao, Jing\|He, Ping\|Zhang, Weizhen
PMID:	25425965

180.
Journal:	Front Physiol. 2014 Nov 7;5:426.
Title:	Diabetes, pancreatic cancer, and metformin therapy.
Author:	Gong, Jun\|Robbins, Lori A\|Lugea, Aurelia\|Waldron, Richard T\|Jeon, Christie Y\|Pandol, Stephen J
PMID:	25426078

181.
Journal:	Pharmacol Res Perspect. 2014 Dec;2(6):e00067.
Title:	Metabolomic evaluation of Mitomycin C and rapamycin in a personalized treatment of pancreatic cancer.
Author:	Navarrete, Alicia\|Armitage, Emily G\|Musteanu, Monica\|Garcia, Antonia\|Mastrangelo, Annalaura\|Bujak, Renata\|Lopez-Casas, Pedro P\|Hidalgo, Manuel\|Barbas, Coral
PMID:	25505613

182.
Journal:	Front Physiol. 2014 Dec 16;5:478.
Title:	Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
Author:	Hubbard, Paul A\|Moody, Colleen L\|Murali, Ramachandran
PMID:	25566081

183.
Journal:	Tumori. 2014 Nov-Dec;100(6):e286-9.
Title:	Rationale and protocol of the MetNET-1 trial, a prospective, single center, phase II study to evaluate the activity and safety of everolimus in combination with octreotide LAR and metformin in patients with advanced pancreatic neuroendocrine tumors.
Author:	Pusceddu, Sara\|de Braud, Filippo\|Concas, Laura\|Bregant, Cristina\|Leuzzi, Livia\|Formisano, Barbara\|Buzzoni, Roberto
PMID:	25688512

184.
Journal:	Oncogene. 2015 Jan 8;34(2):263-8.
Title:	Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma.
Author:	Petrova, E\|Matevossian, A\|Resh, M D
PMID:	24469057

185.
Journal:	Leukemia. 2015 Jan;29(1):27-37.
Title:	Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies.
Author:	Weisberg, Ellen\|Nonami, Atsushi\|Chen, Zhao\|Liu, Feiyang\|Zhang, Jianming\|Sattler, Martin\|Nelson, Erik\|Cowens, Kristen\|Christie, Amanda L\|Mitsiades, Constantine\|Wong, Kwok-Kin\|Liu, Qingsong\|Gray, Nathanael\|Griffin, James D
PMID:	24791855

186.
Journal:	Histopathology. 2015 Jan;66(2):234-43.
Title:	Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma.
Author:	Kaira, Kyoichi\|Sunose, Yutaka\|Arakawa, Kazuhisa\|Sunaga, Noriaki\|Shimizu, Kimihiro\|Tominaga, Hideyuki\|Oriuchi, Noboru\|Nagamori, Shushi\|Kanai, Yoshikatsu\|Oyama, Tetsunari\|Takeyoshi, Izumi
PMID:	24845232

187.
Journal:	Pathol Oncol Res. 2015 Apr;21(2):267-72.
Title:	High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma.
Author:	Shen, Cong-Cong\|Cui, Xin-Yi\|He, Yi\|Kang, Yu-Huan\|Yi, Cheng\|Yang, Jin-Liang\|Gou, Lan-Tu
PMID:	25079376

188.
Journal:	Ann Oncol. 2015 Jan;26(1):58-64.
Title:	A phase IB trial of the oral MEK inhibitor trametinib (GSK1120212) in combination with everolimus in patients with advanced solid tumors.
Author:	Tolcher, A W\|Bendell, J C\|Papadopoulos, K P\|Burris, H A 3rd\|Patnaik, A\|Jones, S F\|Rasco, D\|Cox, D S\|Durante, M\|Bellew, K M\|Park, J\|Le, N T\|Infante, J R
PMID:	25344362

189.
Journal:	Dig Dis Sci. 2015 Apr;60(4):1067-80.
Title:	Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer.
Author:	Mu, Gang-Gang\|Zhang, Ling-Li\|Li, Hong-Yan\|Liao, Yan\|Yu, Hong-Gang
PMID:	25344906

190.
Journal:	Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jan;119(1):e13-9.
Title:	mTOR inhibitor-associated stomatitis (mIAS) in three patients with cancer treated with everolimus.
Author:	Kalogirou, Eleni-Marina\|Tosios, Konstantinos I\|Piperi, Evangelia P\|Sklavounou, Alexandra
PMID:	25442249

191.
Journal:	Invest New Drugs. 2015 Apr;33(2):271-9.
Title:	PBI-05204, a supercritical CO(2) extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway.
Author:	Pan, Yong\|Rhea, Patrea\|Tan, Lin\|Cartwright, Carrie\|Lee, Ho-Jeong\|Ravoori, Murali K\|Addington, Crandell\|Gagea, Mihai\|Kundra, Vikas\|Kim, Sun-Jin\|Newman, Robert A\|Yang, Peiying
PMID:	25476893

192.
Journal:	Biochem Biophys Res Commun. 2015 Jan 16;456(3):821-6.
Title:	The glucosylceramide synthase inhibitor PDMP sensitizes pancreatic cancer cells to MEK/ERK inhibitor AZD-6244.
Author:	Wang, Ting\|Wei, Jue\|Wang, Na\|Ma, Jia-Li\|Hui, Ping-Ping
PMID:	25498501

193.
Journal:	Clin Cancer Res. 2015 Feb 15;21(4):730-8.
Title:	A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors.
Author:	Bedard, Philippe L\|Tabernero, Josep\|Janku, Filip\|Wainberg, Zev A\|Paz-Ares, Luis\|Vansteenkiste, Johan\|Van Cutsem, Eric\|Perez-Garcia, Jose\|Stathis, Anastasios\|Britten, Carolyn D\|Le, Ngocdiep\|Carter, Kirsten\|Demanse, David\|Csonka, Denes\|Peters, Malte\|Zubel,
PMID:	25500057

194.
Journal:	Mol Med Rep. 2015 Apr;11(4):3160-6.
Title:	Sann-Joong-Kuey-Jian-Tang decreases the protein expression of mammalian target of rapamycin but increases microtubule associated protein II light chain 3 expression to inhibit human BxPC3 pancreatic carcinoma cells.
Author:	Su, Chin-Cheng
PMID:	25516264

195.
Journal:	Biochim Biophys Acta. 2015 Mar;1853(3):549-60.
Title:	Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner.
Author:	Fiorini, Claudia\|Cordani, Marco\|Gotte, Giovanni\|Picone, Delia\|Donadelli, Massimo
PMID:	25533084

196.
Journal:	J Biol Chem. 2015 Feb 27;290(9):5592-605.
Title:	Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells.
Author:	Marchand, Benoit\|Arsenault, Dominique\|Raymond-Fleury, Alexandre\|Boisvert, Francois-Michel\|Boucher, Marie-Josee
PMID:	25561726

197.
Journal:	Diabetes. 2015 May;64(5):1632-42.
Title:	Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms.
Author:	Cifarelli, Vincenza\|Lashinger, Laura M\|Devlin, Kaylyn L\|Dunlap, Sarah M\|Huang, Jennifer\|Kaaks, Rudolf\|Pollak, Michael N\|Hursting, Stephen D
PMID:	25576058

198.
Journal:	Int Surg. 2015 Jun;100(6):1089-97.
Title:	Nonfunctional Pancreatic Neuroendocrine Tumors: Advances in Diagnosis, Management, and Controversies.
Author:	Dumlu, Ersin Gurkan\|Karakoc, Derya\|Ozdemir, Arif
PMID:	25590518

199.
Journal:	Drug Des Devel Ther. 2015 Jan 17;9:537-60.
Title:	Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells.
Author:	Wang, Feng\|Wang, Qi\|Zhou, Zhi-Wei\|Yu, Song-Ning\|Pan, Shu-Ting\|He, Zhi-Xu\|Zhang, Xueji\|Wang, Dong\|Yang, Yin-Xue\|Yang, Tianxing\|Sun, Tao\|Li, Min\|Qiu, Jia-Xuan\|Zhou, Shu-Feng
PMID:	25632222

200.
Journal:	Drug Des Devel Ther. 2015 Jan 17;9:575-601.
Title:	Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.
Author:	Wang, Feng\|Li, Hai\|Yan, Xiao-Gang\|Zhou, Zhi-Wei\|Yi, Zhi-Gang\|He, Zhi-Xu\|Pan, Shu-Ting\|Yang, Yin-Xue\|Wang, Zuo-Zheng\|Zhang, Xueji\|Yang, Tianxing\|Qiu, Jia-Xuan\|Zhou, Shu-Feng
PMID:	25632225

201.
Journal:	Int J Mol Sci. 2015 Feb 3;16(2):3267-82.
Title:	mTOR inhibition induces EGFR feedback activation in association with its resistance to human pancreatic cancer.
Author:	Wei, Feng\|Zhang, Yandong\|Geng, Li\|Zhang, Ping\|Wang, Guangyi\|Liu, Yan
PMID:	25654224

202.
Journal:	J Cell Physiol. 2015 Sep;230(9):2212-23.
Title:	LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1alpha and Stat3 Signaling.
Author:	Niu, Fei\|Li, Yan\|Lai, Fang-Fang\|Ni, Lin\|Ji, Ming\|Jin, Jing\|Yang, Han-Ze\|Wang, Chao\|Zhang, Dong-Ming\|Chen, Xiao-Guang
PMID:	25655308

203.
Journal:	Mol Cancer Ther. 2015 Apr;14(4):1014-23.
Title:	Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.
Author:	Soares, Heloisa P\|Ming, Ming\|Mellon, Michelle\|Young, Steven H\|Han, Liang\|Sinnet-Smith, James\|Rozengurt, Enrique
PMID:	25673820

204.
Journal:	Cancer Res. 2015 Mar 15;75(6):1091-101.
Title:	Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer.
Author:	Pettazzoni, Piergiorgio\|Viale, Andrea\|Shah, Parantu\|Carugo, Alessandro\|Ying, Haoqiang\|Wang, Huamin\|Genovese, Giannicola\|Seth, Sahil\|Minelli, Rosalba\|Green, Tessa\|Huang-Hobbs, Emmet\|Corti, Denise\|Sanchez, Nora\|Nezi, Luigi\|Marchesini, Matteo\|Kapoor, Avnish\|
PMID:	25736685

205.
Journal:	J Hepatobiliary Pancreat Sci. 2015 Aug;22(8):623-7.
Title:	Chemotherapy for advanced poorly differentiated pancreatic neuroendocrine carcinoma.
Author:	Ikeda, Masafumi\|Okuyama, Hiroyuki\|Takahashi, Hideaki\|Ohno, Izumi\|Shimizu, Satoshi\|Mitsunaga, Shuichi\|Kondo, Shunsuke\|Morizane, Chigusa\|Ueno, Hideki\|Okusaka, Takuji
PMID:	25755102

206.
Journal:	Bioorg Med Chem. 2015 Apr 1;23(7):1386-94.
Title:	Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
Author:	Van Dort, Marcian E\|Galban, Stefanie\|Wang, Hanxiao\|Sebolt-Leopold, Judith\|Whitehead, Christopher\|Hong, Hao\|Rehemtulla, Alnawaz\|Ross, Brian D
PMID:	25766633

207.
Journal:	PLoS One. 2015 Mar 20;10(3):e0121082.
Title:	Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer.
Author:	Luo, Zhaofan\|Li, Yanan\|Wang, Huamin\|Fleming, Jason\|Li, Min\|Kang, Yaan\|Zhang, Ran\|Li, Donghui
PMID:	25793983

208.
Journal:	Cancer Chemother Pharmacol. 2015 Jun;75(6):1135-41.
Title:	Phase II study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced pancreatic cancer.
Author:	Kordes, S\|Klumpen, H J\|Weterman, M J\|Schellens, J H M\|Richel, D J\|Wilmink, J W
PMID:	25822310

209.
Journal:	EMBO Mol Med. 2015 Jun;7(6):735-53.
Title:	Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance.
Author:	Duluc, Camille\|Moatassim-Billah, Siham\|Chalabi-Dchar, Mounira\|Perraud, Aurelie\|Samain, Remi\|Breibach, Florence\|Gayral, Marion\|Cordelier, Pierre\|Delisle, Marie-Bernadette\|Bousquet-Dubouch, Marie-Pierre\|Tomasini, Richard\|Schmid, Herbert\|Mathonnet, Muriel\|Py
PMID:	25834145

210.
Journal:	Anticancer Res. 2015 Apr;35(4):1941-9.
Title:	Resistance to gemcitabine in the pancreatic cancer cell line KLM1-R reversed by metformin action.
Author:	Baron, Byron\|Wang, Yufeng\|Maehara, Shin-Ichiro\|Maehara, Yoshihiko\|Kuramitsu, Yasuhiro\|Nakamura, Kazuyuki
PMID:	25862846

211.
Journal:	BMC Cancer. 2015 Apr 9;15:241.
Title:	Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer.
Author:	Matsumoto, Masaru\|Seike, Masahiro\|Noro, Rintaro\|Soeno, Chie\|Sugano, Teppei\|Takeuchi, Susumu\|Miyanaga, Akihiko\|Kitamura, Kazuhiro\|Kubota, Kaoru\|Gemma, Akihiko
PMID:	25884680

212.
Journal:	Am J Transl Res. 2015 Feb 15;7(2):356-63. eCollection 2015.
Title:	Relationship between CD147 and expression of amino acid transporters (LAT1 and ASCT2) in patients with pancreatic cancer.
Author:	Kaira, Kyoichi\|Arakawa, Kazuhisa\|Shimizu, Kimihiro\|Oriuchi, Noboru\|Nagamori, Shushi\|Kanai, Yoshikatsu\|Oyama, Tetsunari\|Takeyoshi, Izumi
PMID:	25901202

213.
Journal:	PLoS One. 2015 May 11;10(5):e0126605.
Title:	Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death.
Author:	Akimoto, Miho\|Iizuka, Mari\|Kanematsu, Rie\|Yoshida, Masato\|Takenaga, Keizo
PMID:	25961833

214.
Journal:	Gastroenterol Res Pract. 2015;2015:568981.
Title:	Molecular mechanism of local drug delivery with Paclitaxel-eluting membranes in biliary and pancreatic cancer: new application for an old drug.
Author:	Bang, Sookhee\|Jang, Sung Ill\|Lee, Su Yeon\|Baek, Yi-Yong\|Yun, Jieun\|Oh, Soo Jin\|Lee, Chang Woo\|Jo, Eun Ae\|Na, Kun\|Yang, Sugeun\|Lee, Don Haeng\|Lee, Dong Ki
PMID:	25983747

215.
Journal:	World J Gastroenterol. 2015 May 28;21(20):6127-45.
Title:	New targeted therapies in pancreatic cancer.
Author:	Seicean, Andrada\|Petrusel, Livia\|Seicean, Radu
PMID:	26034349

216.
Journal:	Nucleic Acid Ther. 2015 Aug;25(4):198-208.
Title:	Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines.
Author:	Villalobos, Xenia\|Rodriguez, Laura\|Sole, Anna\|Lliberos, Carolina\|Mencia, Nuria\|Ciudad, Carlos J\|Noe, Veronique
PMID:	26042602

217.
Journal:	Oncotarget. 2015 Aug 7;6(22):19118-31.
Title:	MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.
Author:	Shukla, Surendra K\|Gunda, Venugopal\|Abrego, Jaime\|Haridas, Dhanya\|Mishra, Anusha\|Souchek, Joshua\|Chaika, Nina V\|Yu, Fang\|Sasson, Aaron R\|Lazenby, Audrey J\|Batra, Surinder K\|Singh, Pankaj K
PMID:	26046375

218.
Journal:	Oncotarget. 2015 Aug 28;6(25):21208-24.
Title:	Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2.
Author:	Yue, Wen\|Zheng, Xi\|Lin, Yong\|Yang, Chung S\|Xu, Qing\|Carpizo, Darren\|Huang, Huarong\|DiPaola, Robert S\|Tan, Xiang-Lin
PMID:	26056043

219.
Journal:	Cancer Genet. 2015 Jul-Aug;208(7-8):374-81.
Title:	Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Author:	Boora, Ganesh K\|Kanwar, Rahul\|Kulkarni, Amit A\|Pleticha, Josef\|Ames, Matthew\|Schroth, Gary\|Beutler, Andreas S\|Banck, Michaela S
PMID:	26087898

220.
Journal:	Int J Surg. 2015 Sep;21 Suppl 1:S89-94.
Title:	Everolimus and pancreatic neuroendocrine tumors (PNETs): Activity, resistance and how to overcome it.
Author:	Capozzi, Monica\|Caterina, Ierano\|De Divitiis, Chiara\|von Arx, Claudia\|Maiolino, Piera\|Tatangelo, Fabiana\|Cavalcanti, Ernesta\|Di Girolamo, Elena\|Iaffaioli, Rosario Vincenzo\|Scala, Stefania\|Tafuto, Salvatore
PMID:	26123382

221.
Journal:	Adv Biol Regul. 2015 Sep;59:65-81.
Title:	Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells.
Author:	Fitzgerald, Timothy L\|Lertpiriyapong, Kvin\|Cocco, Lucio\|Martelli, Alberto M\|Libra, Massimo\|Candido, Saverio\|Montalto, Giuseppe\|Cervello, Melchiorre\|Steelman, Linda\|Abrams, Stephen L\|McCubrey, James A
PMID:	26257206

222.
Journal:	DNA Cell Biol. 2015 Oct;34(10):610-7.
Title:	The Antipancreatic Cancer Activity of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2.
Author:	Chen, Bo\|Xu, Ming\|Zhang, Hui\|Xu, Ming-zheng\|Wang, Xu-jing\|Tang, Qing-he\|Tang, Jian-ying
PMID:	26284306

223.
Journal:	Front Horm Res. 2015;44:115-38.
Title:	Genetics and Epigenetics of Pancreatic Neuroendocrine Tumors and Pulmonary Carcinoids.
Author:	Dreijerink, Koen M A\|Derks, Jules L\|Cataldo, Ivana\|Scarpa, Aldo\|Valk, Gerlof D\|Speel, Ernst-Jan M
PMID:	26303708

224.
Journal:	Cancer Lett. 2015 Dec 1;369(1):192-201.
Title:	Radiosensitization of metformin in pancreatic cancer cells via abrogating the G2 checkpoint and inhibiting DNA damage repair.
Author:	Wang, Zheng\|Lai, Song-Tao\|Ma, Ning-Yi\|Deng, Yun\|Liu, Yong\|Wei, Dong-Ping\|Zhao, Jian-Dong\|Jiang, Guo-Liang
PMID:	26304716

225.
Journal:	Eur Rev Med Pharmacol Sci. 2015 Aug;19(16):3072-9.
Title:	Rapamycin inhibits the proliferation of SW1990 pancreatic cancer cell.
Author:	Xu, M\|Bu, L-M\|Wu, K\|Lu, L-G\|Wang, X-P
PMID:	26367731

226.
Journal:	Oncogenesis. 2015 Oct 5;4:e169.
Title:	PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors.
Author:	Payne, S N\|Maher, M E\|Tran, N H\|Van De Hey, D R\|Foley, T M\|Yueh, A E\|Leystra, A A\|Pasch, C A\|Jeffrey, J J\|Clipson, L\|Matkowskyj, K A\|Deming, D A
PMID:	26436951

227.
Journal:	Oncotarget. 2015 Oct 13;6(31):32039-60.
Title:	PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth.
Author:	Sharma, Narinder\|Nanta, Rajesh\|Sharma, Jay\|Gunewardena, Sumedha\|Singh, Karan P\|Shankar, Sharmila\|Srivastava, Rakesh K
PMID:	26451606

228.
Journal:	Hepatobiliary Pancreat Dis Int. 2015 Dec;14(6):642-50.
Title:	Trametinib and dactolisib but not regorafenib exert antiproliferative effects on rat pancreatic stellate cells.
Author:	Witteck, Laura\|Jaster, Robert
PMID:	26663013

229.
Journal:	Mol Cancer. 2015 Dec 18;14:212.
Title:	Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma.
Author:	Kong, Bo\|Cheng, Tao\|Qian, Chengjia\|Wu, Weiwei\|Steiger, Katja\|Cao, Jing\|Schlitter, Anna Melissa\|Regel, Ivonne\|Raulefs, Susanne\|Friess, Helmut\|Erkan, Mert\|Esposito, Irene\|Kleeff, Jorg\|Michalski, Christoph W
PMID:	26683340

230.
Journal:	Ann Surg. 2016 Jan;263(1):153-61.
Title:	Reliable Detection of Somatic Mutations in Fine Needle Aspirates of Pancreatic Cancer With Next-generation Sequencing: Implications for Surgical Management.
Author:	Valero, Vicente 3rd\|Saunders, Tyler J\|He, Jin\|Weiss, Matthew J\|Cameron, John L\|Dholakia, Avani\|Wild, Aaron T\|Shin, Eun Ji\|Khashab, Mouen A\|O'Broin-Lennon, Anne Marie\|Ali, Syed Z\|Laheru, Daniel\|Hruban, Ralph H\|Iacobuzio-Donahue, Christine A\|Herman, Joseph
PMID:	26020105

231.
Journal:	Crit Rev Oncol Hematol. 2016 Feb;98:264-74.
Title:	Gastrointestinal neuroendocrine tumors: Searching the optimal treatment strategy--A literature review.
Author:	Berardi, Rossana\|Rinaldi, Silvia\|Torniai, Mariangela\|Morgese, Francesca\|Partelli, Stefano\|Caramanti, Miriam\|Onofri, Azzurra\|Polenta, Vanessa\|Pagliaretta, Silvia\|Falconi, Massimo\|Cascinu, Stefano
PMID:	26643525

232.
Journal:	Cancer Cell. 2016 Jan 11;29(1):75-89.
Title:	Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.
Author:	Hayes, Tikvah K\|Neel, Nicole F\|Hu, Chaoxin\|Gautam, Prson\|Chenard, Melissa\|Long, Brian\|Aziz, Meraj\|Kassner, Michelle\|Bryant, Kirsten L\|Pierobon, Mariaelena\|Marayati, Raoud\|Kher, Swapnil\|George, Samuel D\|Xu, Mai\|Wang-Gillam, Andrea\|Samatar, Ahmed A\|Maitra,
PMID:	26725216

233.
Journal:	PLoS One. 2016 Jan 13;11(1):e0147113.
Title:	Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts.
Author:	Lipner, Matthew B\|Marayati, Raoud\|Deng, Yangmei\|Wang, Xianxi\|Raftery, Laura\|O'Neil, Bert H\|Yeh, Jen Jen
PMID:	26760500

234.
Journal:	Sci Rep. 2016 Jan 25;6:19819.
Title:	Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition.
Author:	Subramani, Ramadevi\|Gonzalez, Elizabeth\|Arumugam, Arunkumar\|Nandy, Sushmita\|Gonzalez, Viviana\|Medel, Joshua\|Camacho, Fernando\|Ortega, Andrew\|Bonkoungou, Sandrine\|Narayan, Mahesh\|Dwivedi, Alok kumar\|Lakshmanaswamy, Rajkumar
PMID:	26804739

235.
Journal:	Cell Rep. 2016 Feb 9;14(5):979-990.
Title:	Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities.
Author:	Franco, Jorge\|Balaji, Uthra\|Freinkman, Elizaveta\|Witkiewicz, Agnieszka K\|Knudsen, Erik S
PMID:	26804906

236.
Journal:	Gan To Kagaku Ryoho. 2016 Jan;43(1):107-10.
Title:	[Treatment Strategy for Non-Functional Pancreatic Neuroendocrine Tumors (P-NETs) at Kurume University Hospital].
Author:	Kawashima, Yusuke\|Ishikawa, Hiroto\|Hisaka, Toru\|Okuda, Kouji\|Akagi, Yoshito
PMID:	26809536

237.
Journal:	PLoS One. 2016 Feb 5;11(2):e0148999.
Title:	The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells.
Author:	Su, Hsin-Yuan\|Waldron, Richard T\|Gong, Raymond\|Ramanujan, V Krishnan\|Pandol, Stephen J\|Lugea, Aurelia
PMID:	26849807

238.
Journal:	Zhonghua Yi Xue Za Zhi. 2016 Feb;96(6):438-41.
Title:	[Inhibition of Sirolimus on the growth of pancreatic carcinoma and its effect on the expression of glucose transporter and hexokinase ].
Author:	Huang, J P\|Zhang, J L\|Hua, Y\|Huang, P\|Ge, C L
PMID:	26875919

239.
Journal:	Oncotarget. 2016 Mar 29;7(13):16396-408.
Title:	MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor.
Author:	Kuninty, Praneeth R\|Bojmar, Linda\|Tjomsland, Vegard\|Larsson, Marie\|Storm, Gert\|Ostman, Arne\|Sandstrom, Per\|Prakash, Jai
PMID:	26918939

240.
Journal:	Oncologist. 2016 Jul;21(7):875-86.
Title:	Efficacy and Safety of Everolimus in Extrapancreatic Neuroendocrine Tumor: A Comprehensive Review of Literature.
Author:	Faggiano, Antongiulio\|Malandrino, Pasqualino\|Modica, Roberta\|Agrimi, Daniela\|Aversano, Maurizio\|Bassi, Vincenzo\|Giordano, Ernesto A\|Guarnotta, Valentina\|Logoluso, Francesco A\|Messina, Erika\|Nicastro, Vincenzo\|Nuzzo, Vincenzo\|Sciaraffia, Marcello\|Colao, An
PMID:	27053503

241.
Journal:	Oncol Lett. 2016 Apr;11(4):2773-2779.
Title:	ASF-4-1 fibroblast-rich culture increases chemoresistance and mTOR expression of pancreatic cancer BxPC-3 cells at the invasive front in vitro, and promotes tumor growth and invasion in vivo.
Author:	Fujiwara, Masaya\|Kanayama, Kazuki\|Hirokawa, Yoshifumi S\|Shiraishi, Taizo
PMID:	27073551

242.
Journal:	J Cancer Res Clin Oncol. 2016 Oct;142(10):2159-71.
Title:	Metformin in pancreatic cancer treatment: from clinical trials through basic research to biomarker quantification.
Author:	Bhaw-Luximon, Archana\|Jhurry, Dhanjay
PMID:	27160287

243.
Journal:	Mol Med Rep. 2016 Jul;14(1):599-605.
Title:	()Epigallocatechin3gallate induces apoptosis in human pancreatic cancer cells via PTEN.
Author:	Liu, Shi\|Xu, Zhong-Ling\|Sun, Li\|Liu, Ying\|Li, Cheng-Chong\|Li, Hong-Mei\|Zhang, Wei\|Li, Cheng-Jun\|Qin, Wei
PMID:	27176210

244.
Journal:	Clin Cancer Res. 2016 Dec 1;22(23):5805-5817.
Title:	Therapeutic Benefit of Selective Inhibition of p110alpha PI3-Kinase in Pancreatic Neuroendocrine Tumors.
Author:	Soler, Adriana\|Figueiredo, Ana M\|Castel, Pau\|Martin, Laura\|Monelli, Erika\|Angulo-Urarte, Ana\|Mila-Guasch, Maria\|Vinals, Francesc\|Baselga, Jose\|Casanovas, Oriol\|Graupera, Mariona
PMID:	27225693

245.
Journal:	Mol Cancer. 2016 Jun 27;15(1):49.
Title:	Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition.
Author:	Miyazaki, Yumi\|Matsubara, Shyuichirou\|Ding, Qiang\|Tsukasa, Koichiro\|Yoshimitsu, Makoto\|Kosai, Ken-Ichiro\|Takao, Sonshin
PMID:	27349387

246.
Journal:	Asia Pac J Clin Oncol. 2016 Dec;12(4):396-402.
Title:	The efficacy and safety of everolimus for the treatment of progressive gastroenteropancreatic neuroendocrine tumors: A multi-institution observational study in Taiwan.
Author:	Liu, Chien-Ting\|Chen, Ming-Huang\|Chen, Jen-Shi\|Chen, Li-Tzong\|Shan, Yan-Shen\|Lu, Chang-Hsien\|Su, Yu-Li\|Ku, Fan-Chen\|Chou, Wen-Chi\|Chen, Yen-Yang
PMID:	27357443

247.
Journal:	Neoplasia. 2016 Jul;18(7):425-35.
Title:	Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma.
Author:	Wong, Matthew H\|Xue, Aiqun\|Baxter, Robert C\|Pavlakis, Nick\|Smith, Ross C
PMID:	27435925

248.
Journal:	Cancer Med. 2016 Oct;5(10):2953-2964.
Title:	The pivotal role of mammalian target of rapamycin inhibition in the treatment of patients with neuroendocrine tumors.
Author:	Phan, Alexandria T\|Dave, Bhuvanesh
PMID:	27539383

249.
Journal:	Oncotarget. 2016 Sep 20;7(38):62006-62018.
Title:	CXCL12-CXCR7 axis contributes to the invasive phenotype of pancreatic cancer.
Author:	Guo, Jun-Chao\|Li, Jian\|Zhou, Li\|Yang, Jian-Yu\|Zhang, Zhi-Gang\|Liang, Zhi-Yong\|Zhou, Wei-Xun\|You, Lei\|Zhang, Tai-Ping\|Zhao, Yu-Pei
PMID:	27542220

250.
Journal:	Pharmacol Ther. 2016 Dec;168:29-42.
Title:	KRAS-related proteins in pancreatic cancer.
Author:	Mann, Karen M\|Ying, Haoqiang\|Juan, Joseph\|Jenkins, Nancy A\|Copeland, Neal G
PMID:	27595930

251.
Journal:	Cancer Genet. 2016 Dec;209(12):567-581.
Title:	Molecular targeted therapy for pancreatic adenocarcinoma: A review of completed and ongoing late phase clinical trials.
Author:	Mosquera, Catalina\|Maglic, Dino\|Zervos, Emmanuel E
PMID:	27613577

252.
Journal:	CNS Oncol. 2016 Oct;5(4):203-9.
Title:	Widely metastatic atypical pituitary adenoma with mTOR pathway STK11(F298L) mutation treated with everolimus therapy.
Author:	Donovan, Laura E\|Arnal, Ashley V\|Wang, Shih-Hsiu\|Odia, Yazmin
PMID:	27615706

253.
Journal:	Eur J Radiol. 2016 Oct;85(10):1804-1810.
Title:	The correlation between FDG uptake and biological molecular markers in pancreatic cancer patients.
Author:	Kaida, Hayato\|Azuma, Koichi\|Kawahara, Akihiko\|Yasunaga, Masafumi\|Kitasato, Yuhei\|Hattori, Satoshi\|Taira, Tomoki\|Ureshino, Hiroki\|Kage, Masayoshi\|Ishii, Kazunari\|Murakami, Takamichi\|Ishibashi, Masatoshi
PMID:	27666620

254.
Journal:	Sci Rep. 2016 Sep 29;6:33146.
Title:	Interplay between cell cycle and autophagy induced by boswellic acid analog.
Author:	Pathania, Anup S\|Guru, Santosh K\|Kumar, Suresh\|Kumar, Ashok\|Ahmad, Masroor\|Bhushan, Shashi\|Sharma, Parduman R\|Mahajan, Priya\|Shah, Bhahwal A\|Sharma, Simmi\|Nargotra, Amit\|Vishwakarma, Ram\|Korkaya, Hasan\|Malik, Fayaz
PMID:	27680387

255.
Journal:	Sci Rep. 2016 Oct 3;6:34564.
Title:	Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy.
Author:	Liao, Gaoyong\|Gao, Bing\|Gao, Yingnv\|Yang, Xuegan\|Cheng, Xiaodong\|Ou, Yu
PMID:	27694919

256.
Journal:	Cancer Res. 2016 Dec 1;76(23):6911-6923.
Title:	mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.
Author:	Driscoll, David R\|Karim, Saadia A\|Sano, Makoto\|Gay, David M\|Jacob, Wright\|Yu, Jun\|Mizukami, Yusuke\|Gopinathan, Aarthi\|Jodrell, Duncan I\|Evans, T R Jeffry\|Bardeesy, Nabeel\|Hall, Michael N\|Quattrochi, Brian J\|Klimstra, David S\|Barry, Simon T\|Sansom, Owen J\|
PMID:	27758884

257.
Journal:	Oncotarget. 2016 Nov 22;7(47):78029-78047.
Title:	HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer.
Author:	Rumman, Marufa\|Jung, Kyung Hee\|Fang, Zhenghuan\|Yan, Hong Hua\|Son, Mi Kwon\|Kim, Soo Jung\|Kim, Juyoung\|Park, Jung Hee\|Lim, Joo Han\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	27793006

258.
Journal:	Anticancer Res. 2016 Dec;36(12):6347-6356.
Title:	Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Author:	Pectasides, Dimitrios\|Kotoula, Vasiliki\|Papaxoinis, George\|Alexopoulou, Zoi\|Dervenis, Christos\|Samantas, Epaminontas\|Papaparaskeva, Kleo\|Charalambous, Elpida\|Gkakou, Chrysoula\|Agalianos, Christos\|Kalogeras, Konstantine T\|Pentheroudakis, George\|Fountzilas,
PMID:	27919956

259.
Journal:	Metabolomics (Los Angel). 2016;6(3).
Title:	Effects of Metformin and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Author:	Soliman, Ghada A\|Steenson, Sharalyn M\|Etekpo, Asserewou H
PMID:	28217402

260.
Journal:	Immunobiology. 2017 Jan;222(1):1-10.
Title:	Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14(++)CD16(-)) monocytes via PI3K/Akt/mTOR-dependent signalling pathway.
Author:	Lenart, Marzena\|Rutkowska-Zapala, Magdalena\|Baj-Krzyworzeka, Monika\|Szatanek, Rafal\|Weglarczyk, Kazimierz\|Smallie, Timothy\|Ziegler-Heitbrock, Loms\|Zembala, Marek\|Siedlar, Maciej
PMID:	26210045

261.
Journal:	Cancer Res. 2017 Jan 15;77(2):320-329.
Title:	IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
Author:	Rajurkar, Mihir\|Dang, Kyvan\|Fernandez-Barrena, Maite G\|Liu, Xiangfan\|Fernandez-Zapico, Martin E\|Lewis, Brian C\|Mao, Junhao
PMID:	28069799

262.
Journal:	Clin Cancer Res. 2017 May 1;23(9):2143-2153.
Title:	Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.
Author:	Kudinov, Alexander E\|Karanicolas, John\|Golemis, Erica A\|Boumber, Yanis
PMID:	28143872

263.
Journal:	J Cell Biochem. 2017 Sep;118(9):2722-2730.
Title:	Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G2 /M Arrest.
Author:	Peng, Tao\|Dou, Q Ping
PMID:	28165150

264.
Journal:	Curr Med Chem. 2017;24(13):1321-1331.
Title:	Targeting the Akt/PI3K Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer.
Author:	Ebrahimi, Safieh\|Hosseini, Mina\|Shahidsales, Soodabeh\|Maftouh, Mina\|Ferns, Gordon A\|Ghayour-Mobarhan, Majid\|Hassanian, Seyed Mahdi\|Avan, Amir
PMID:	28176634

265.
Journal:	Anticancer Res. 2017 Feb;37(2):705-712.
Title:	Detection of Somatic Mutations in Gastroenteropancreatic Neuroendocrine Tumors Using Targeted Deep Sequencing.
Author:	Backman, Samuel\|Norlen, Olov\|Eriksson, Barbro\|Skogseid, Britt\|Stalberg, Peter\|Crona, Joakim
PMID:	28179320

266.
Journal:	Expert Opin Emerg Drugs. 2017 Mar;22(1):77-86.
Title:	Emerging protein kinase inhibitors for treating pancreatic cancer.
Author:	Furuse, Junji\|Nagashima, Fumio
PMID:	28253828

267.
Journal:	Cancer Sci. 2017 Jun;108(6):1101-1108.
Title:	A vicious partnership between AKT and PHLDA3 to facilitate neuroendocrine tumors.
Author:	Takikawa, Masahiro\|Ohki, Rieko
PMID:	28295876

268.
Journal:	Gastroenterology. 2017 Jul;153(1):277-291.e19.
Title:	Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice.
Author:	Jiang, Shu-Heng\|Li, Jun\|Dong, Fang-Yuan\|Yang, Jian-Yu\|Liu, De-Jun\|Yang, Xiao-Mei\|Wang, Ya-Hui\|Yang, Min-Wei\|Fu, Xue-Liang\|Zhang, Xiao-Xin\|Li, Qing\|Pang, Xiu-Feng\|Huo, Yan-Miao\|Li, Jiao\|Zhang, Jun-Feng\|Lee, Ho-Young\|Lee, Su-Jae\|Qin, Wen-Xin\|Gu, Jian-Ren\|Su
PMID:	28315323

269.
Journal:	Nutrients. 2017 Mar 27;9(4). pii: nu9040331.
Title:	Engineered Resistant-Starch (ERS) Diet Shapes Colon Microbiota Profile in Parallel with the Retardation of Tumor Growth in In Vitro and In Vivo Pancreatic Cancer Models.
Author:	Panebianco, Concetta\|Adamberg, Kaarel\|Adamberg, Signe\|Saracino, Chiara\|Jaagura, Madis\|Kolk, Kaia\|Di Chio, Anna Grazia\|Graziano, Paolo\|Vilu, Raivo\|Pazienza, Valerio
PMID:	28346394

270.
Journal:	Int J Oncol. 2017 May;50(5):1792-1800.
Title:	A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Author:	Liu, Wensheng\|Zhang, Bo\|Hu, Qiangsheng\|Qin, Yi\|Xu, Wenyan\|Shi, Si\|Liang, Chen\|Meng, Qingcai\|Xiang, Jinfeng\|Liang, Dingkong\|Ji, Shunrong\|Liu, Jiang\|Hu, Pengfei\|Liu, Liang\|Liu, Chen\|Long, Jiang\|Ni, Quanxing\|Yu, Xianjun\|Xu, Jin
PMID:	28350132

271.
Journal:	J Hematol Oncol. 2017 Mar 28;10(1):76.
Title:	The role of stromal cancer-associated fibroblasts in pancreatic cancer.
Author:	von Ahrens, Dagny\|Bhagat, Tushar D\|Nagrath, Deepak\|Maitra, Anirban\|Verma, Amit
PMID:	28351381

272.
Journal:	Biochem Biophys Res Commun. 2017 May 13;486(4):1097-1102.
Title:	Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling.
Author:	Huang, Xunwei\|Huang, Li\|Shao, Minhua
PMID:	28377226

273.
Journal:	Onco Targets Ther. 2017 Apr 12;10:2115-2126.
Title:	A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway.
Author:	Zhao, Lei\|Li, Cheng\|Liu, Fei\|Zhao, Yonghong\|Liu, Jun\|Hua, Ye\|Liu, Jinyang\|Huang, Jiapeng\|Ge, Chunlin
PMID:	28442920

274.
Journal:	Oncotarget. 2017 Apr 11;8(15):24491-24505.
Title:	Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models.
Author:	Schmidt, Katharina M\|Hellerbrand, Claus\|Ruemmele, Petra\|Michalski, Christoph W\|Kong, Bo\|Kroemer, Alexander\|Hackl, Christina\|Schlitt, Hans J\|Geissler, Edward K\|Lang, Sven A
PMID:	28445935

275.
Journal:	Cancer Lett. 2017 Aug 1;400:69-78.
Title:	microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression.
Author:	Gu, Dian-Na\|Jiang, Ming-Jie\|Mei, Zhu\|Dai, Juan-Juan\|Dai, Chen-Yun\|Fang, Chi\|Huang, Qian\|Tian, Ling
PMID:	28450156

276.
Journal:	Oncotarget. 2017 Jun 20;8(25):41044-41063.
Title:	Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?
Author:	Mohamed, Amira\|Romano, David\|Saveanu, Alexandru\|Roche, Catherine\|Albertelli, Manuela\|Barbieri, Federica\|Brue, Thierry\|Niccoli, Patricia\|Delpero, Jean-Robert\|Garcia, Stephane\|Ferone, Diego\|Florio, Tullio\|Moutardier, Vincent\|Poizat, Flora\|Barlier, Anne\|Gera
PMID:	28454119

277.
Journal:	Cancers (Basel). 2017 May 17;9(5). pii: cancers9050052.
Title:	Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways.
Author:	Wee, Ping\|Wang, Zhixiang
PMID:	28513565

278.
Journal:	Oncotarget. 2017 Jul 4;8(27):44295-44311.
Title:	Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Author:	Ning, Changwen\|Liang, Min\|Liu, Shuang\|Wang, Guan\|Edwards, Holly\|Xia, Yang\|Polin, Lisa\|Dyson, Gregory\|Taub, Jeffrey W\|Mohammad, Ramzi M\|Azmi, Asfar S\|Zhao, Lijing\|Ge, Yubin
PMID:	28574828

279.
Journal:	Oncotarget. 2017 Jul 4;8(27):44669-44681.
Title:	BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.
Author:	Saiyin, Hexige\|Na, Ning\|Han, Xu\|Fang, Yuan\|Wu, Yanhua\|Lou, Wenhui\|Yang, Xianmei
PMID:	28591720

280.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G524-G536.
Title:	Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges.
Author:	Maertin, Sandrina\|Elperin, Jason M\|Lotshaw, Ethan\|Sendler, Matthias\|Speakman, Steven D\|Takakura, Kazuki\|Reicher, Benjamin M\|Mareninova, Olga A\|Grippo, Paul J\|Mayerle, Julia\|Lerch, Markus M\|Gukovskaya, Anna S
PMID:	28705806

281.
Journal:	Sci Rep. 2017 Aug 11;7(1):7950.
Title:	Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer.
Author:	Chen, Ru\|Lai, Lisa A\|Sullivan, Yumi\|Wong, Melissa\|Wang, Lei\|Riddell, Jonah\|Jung, Linda\|Pillarisetty, Venu G\|Brentnall, Teresa A\|Pan, Sheng
PMID:	28801576

282.
Journal:	Biomol Ther (Seoul). 2017 Nov 1;25(6):609-617.
Title:	alpha, gamma-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines.
Author:	Kim, Myoungjae\|Chin, Young-Won\|Lee, Eun Joo
PMID:	28822990

283.
Journal:	Onco Targets Ther. 2017 Aug 10;10:3991-4005.
Title:	Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases.
Author:	Xie, Zu-Cheng\|Dang, Yi-Wu\|Wei, Dan-Ming\|Chen, Peng\|Tang, Rui-Xue\|Huang, Qian\|Liu, Jiang-Hua\|Luo, Dian-Zhong
PMID:	28860807

284.
Journal:	Mol Cancer Ther. 2017 Nov;16(11):2432-2441.
Title:	mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.
Author:	Orr-Asman, Melissa A\|Chu, Zhengtao\|Jiang, Min\|Worley, Mariah\|LaSance, Kathleen\|Koch, Sheryl E\|Carreira, Vinicius S\|Dahche, Hanan M\|Plas, David R\|Komurov, Kakajan\|Qi, Xiaoyang\|Mercer, Carol A\|Anthony, Lowell B\|Rubinstein, Jack\|Thomas, Hala E
PMID:	28864682

285.
Journal:	Biochem Biophys Res Commun. 2017 Nov 4;493(1):455-460.
Title:	A natural product toosendanin inhibits epithelial-mesenchymal transition and tumor growth in pancreatic cancer via deactivating Akt/mTOR signaling.
Author:	Pei, Zhe\|Fu, Wei\|Wang, Gongping
PMID:	28870807

286.
Journal:	Cancer Discov. 2017 Nov;7(11):1266-1283.
Title:	A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Author:	Rebecca, Vito W\|Nicastri, Michael C\|McLaughlin, Noel\|Fennelly, Colin\|McAfee, Quentin\|Ronghe, Amruta\|Nofal, Michel\|Lim, Chun-Yan\|Witze, Eric\|Chude, Cynthia I\|Zhang, Gao\|Alicea, Gretchen M\|Piao, Shengfu\|Murugan, Sengottuvelan\|Ojha, Rani\|Levi, Samuel M\|Wei,
PMID:	28899863

287.
Journal:	Mol Cell. 2017 Sep 21;67(6):936-946.e5.
Title:	mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.
Author:	Nofal, Michel\|Zhang, Kevin\|Han, Seunghun\|Rabinowitz, Joshua D
PMID:	28918901

288.
Journal:	Bioorg Med Chem Lett. 2017 Nov 1;27(21):4898-4903.
Title:	Discovery of potential antiausterity agents from the Japanese cypress Chamaecyparis obtusa.
Author:	Dibwe, Dya Fita\|Sun, Sijia\|Ueda, Jun-Ya\|Balachandran, Chandrasekar\|Matsumoto, Kinzo\|Awale, Suresh
PMID:	28947153

289.
Journal:	ACS Nano. 2017 Oct 24;11(10):10159-10174.
Title:	Hypoxia-Targeting, Tumor Microenvironment Responsive Nanocluster Bomb for Radical-Enhanced Radiotherapy.
Author:	Huo, Da\|Liu, Sen\|Zhang, Chao\|He, Jian\|Zhou, Zhengyang\|Zhang, Hao\|Hu, Yong
PMID:	28992409

290.
Journal:	Sci Rep. 2017 Oct 10;7(1):12891.
Title:	Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry.
Author:	Duan, Qingke\|Zhao, Hengqiang\|Zhang, Zhengle\|Li, Hehe\|Wu, Heshui\|Shen, Qiang\|Wang, Chunyou\|Yin, Tao
PMID:	29018223

291.
Journal:	Mol Cancer. 2017 Oct 27;16(1):167.
Title:	miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer.
Author:	Long, Manmei\|Zhan, Ming\|Xu, Sunwang\|Yang, Ruimeng\|Chen, Wei\|Zhang, Shilei\|Shi, Yongheng\|He, Qiao\|Mohan, Man\|Liu, Qiang\|Wang, Jian
PMID:	29078789

292.
Journal:	Geburtshilfe Frauenheilkd. 2017 Oct;77(10):1095-1103.
Title:	PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track?
Author:	Gasparri, Maria Luisa\|Bardhi, Erlisa\|Ruscito, Ilary\|Papadia, Andrea\|Farooqi, Ammad Ahmad\|Marchetti, Claudia\|Bogani, Giorgio\|Ceccacci, Irene\|Mueller, Michael D\|Benedetti Panici, Pierluigi
PMID:	29093603

293.
Journal:	Oncotarget. 2017 Jun 29;8(49):85054-85067.
Title:	Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer.
Author:	Espindola-Netto, Jair Machado\|Chini, Claudia C S\|Tarrago, Mariana\|Wang, Enfeng\|Dutta, Shamit\|Pal, Krishnendu\|Mukhopadhyay, Debabrata\|Sola-Penna, Mauro\|Chini, Eduardo N
PMID:	29156703

294.
Journal:	World J Gastroenterol. 2017 Nov 14;23(42):7551-7562.
Title:	Combined treatment of pancreatic cancer xenograft with (90)Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor.
Author:	Aung, Winn\|Tsuji, Atsushi B\|Sudo, Hitomi\|Sugyo, Aya\|Ukai, Yoshinori\|Kouda, Katsushi\|Kurosawa, Yoshikazu\|Furukawa, Takako\|Saga, Tsuneo\|Higashi, Tatsuya
PMID:	29204055

295.
Journal:	Oncotarget. 2017 Jun 28;8(55):93464-93475.
Title:	Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next-generation sequencing panel.
Author:	Gleeson, Ferga C\|Voss, Jesse S\|Kipp, Benjamin R\|Kerr, Sarah E\|Van Arnam, John S\|Mills, John R\|Marcou, Cherisse A\|Schneider, Amber R\|Tu, Zheng Jin\|Henry, Michael R\|Levy, Michael J
PMID:	29212165

296.
Journal:	Oncotarget. 2017 Sep 16;8(58):98068-98083.
Title:	The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.
Author:	Chang, Tsung-Ming\|Shan, Yan-Shen\|Chu, Pei-Yi\|Jiang, Shih Sheng\|Hung, Wen-Chun\|Chen, Yu-Lin\|Tu, Hsiu-Chi\|Lin, Hui-You\|Tsai, Hui-Jen\|Chen, Li-Tzong
PMID:	29228674

297.
Journal:	Cell Death Dis. 2017 Dec 12;8(12):3204.
Title:	Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL.
Author:	Elia, Androulla\|Henry-Grant, Ricky\|Adiseshiah, Charlotte\|Marboeuf, Catherine\|Buckley, Rebecca J\|Clemens, Michael J\|Mudan, Satvinder\|Pyronnet, Stephane
PMID:	29233971

298.
Journal:	Oncotarget. 2017 Oct 9;8(61):103167-103181.
Title:	Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling.
Author:	Zhou, Jingkai\|Zhao, Tiangang\|Ma, Linfeng\|Liang, Min\|Guo, Ying-Jie\|Zhao, Li-Mei
PMID:	29262554

299.
Journal:	Oncotarget. 2017 Oct 9;8(61):103613-103625.
Title:	Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors.
Author:	Chu, Pei-Yi\|Jiang, Shih Sheng\|Shan, Yan-Shen\|Hung, Wen-Chun\|Chen, Ming-Huang\|Lin, Hui-You\|Chen, Yu-Lin\|Tsai, Hui-Jen\|Chen, Li-Tzong
PMID:	29262588

300.
Journal:	Rom J Morphol Embryol. 2017;58(4):1257-1262.
Title:	The tyrosine kinase inhibitors effects on metastatic tumor graft in the chick chorioallantoic membrane assay.
Author:	Ciolofan, Alexandru\|Cretu, Octavian Marius\|Mogoanta, Stelian Stefanita\|Ciuca, Eduard Mihai
PMID:	29556614

301.
Journal:	Endocr Pathol. 2018 Mar;29(1):21-26.
Title:	Expanding the Spectrum of Colonic Manifestations in Tuberous Sclerosis: L-Cell Neuroendocrine Tumor Arising in the Background of Rectal PEComa.
Author:	Kolin, David L\|Duan, Kai\|Ngan, Bo\|Gerstle, J Ted\|Krzyzanowska, Monika K\|Somers, Gino R\|Mete, Ozgur
PMID:	28733877

302.
Journal:	Mol Cancer Ther. 2018 Jan;17(1):60-72.
Title:	Combinatorial Treatment with mTOR Inhibitors and Streptozotocin Leads to Synergistic In Vitro and In Vivo Antitumor Effects in Insulinoma Cells.
Author:	Bollard, Julien\|Patte, Celine\|Massoma, Patrick\|Goddard, Isabelle\|Gadot, Nicolas\|Benslama, Noura\|Hervieu, Valerie\|Ferraro-Peyret, Carole\|Cordier-Bussat, Martine\|Scoazec, Jean-Yves\|Roche, Colette\|Walter, Thomas\|Vercherat, Cecile
PMID:	29051320

303.
Journal:	J Endocrinol. 2018 Mar;236(3):R161-R167.
Title:	Genomic landscape of pancreatic neuroendocrine tumours: the International Cancer Genome Consortium.
Author:	Mafficini, Andrea\|Scarpa, Aldo
PMID:	29321190

304.
Journal:	Br J Cancer. 2018 Feb 6;118(3):366-377.
Title:	MTOR inhibitor-based combination therapies for pancreatic cancer.
Author:	Hassan, Zonera\|Schneeweis, Christian\|Wirth, Matthias\|Veltkamp, Christian\|Dantes, Zahra\|Feuerecker, Benedikt\|Ceyhan, Guralp O\|Knauer, Shirley K\|Weichert, Wilko\|Schmid, Roland M\|Stauber, Roland\|Arlt, Alexander\|Kramer, Oliver H\|Rad, Roland\|Reichert, Maximili
PMID:	29384525

305.
Journal:	Oncol Res. 2018 Aug 23;26(7):1123-1131.
Title:	Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Author:	Liu, Xinlu\|Tan, Xiaodong\|Liu, Peng\|Wu, Yunhao\|Qian, Songying\|Zhang, Xiaobo
PMID:	29386088

306.
Journal:	Cell Death Dis. 2018 Feb 12;9(2):210.
Title:	Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells.
Author:	Nath, Shalini\|Mandal, Chhabinath\|Chatterjee, Uttara\|Mandal, Chitra
PMID:	29434218

307.
Journal:	Oncol Lett. 2018 Feb;15(2):1811-1816.
Title:	Metformin synergizes with rapamycin to inhibit the growth of pancreatic cancer in vitro and in vivo.
Author:	Zhang, Jia-Wei\|Zhao, Fan\|Sun, Qing
PMID:	29434877

308.
Journal:	Oncol Lett. 2018 Feb;15(2):2085-2090.
Title:	Fyn knockdown inhibits migration and invasion in cholangiocarcinoma through the activated AMPK/mTOR signaling pathway.
Author:	Lyu, Shao-Cheng\|Han, Dong-Dong\|Li, Xian-Liang\|Ma, Jun\|Wu, Qiao\|Dong, Hong-Meng\|Bai, Chun\|He, Qiang
PMID:	29434909

309.
Journal:	Eur Rev Med Pharmacol Sci. 2018 Feb;22(3):678-686.
Title:	MiR-1271 negatively regulates AKT/MTOR signaling and promotes apoptosis via targeting PDK1 in pancreatic cancer.
Author:	Xie, F\|Huang, Q\|Liu, C-H\|Lin, X-S\|Liu, Z\|Liu, L-L\|Huang, D-W\|Zhou, H-C
PMID:	29461595

310.
Journal:	Adv Biol Regul. 2018 May;68:13-30.
Title:	Metformin influences drug sensitivity in pancreatic cancer cells.
Author:	Candido, Saverio\|Abrams, Stephen L\|Steelman, Linda\|Lertpiriyapong, Kvin\|Martelli, Alberto M\|Cocco, Lucio\|Ratti, Stefano\|Follo, Matilde Y\|Murata, Ramiro M\|Rosalen, Pedro L\|Lombardi, Paolo\|Montalto, Giuseppe\|Cervello, Melchiorre\|Gizak, Agnieszka\|Rakus, Dari
PMID:	29482945

311.
Journal:	Pancreas. 2018 Apr;47(4):502-510.
Title:	Site-Specific Genomic Alterations in a Well-Differentiated Pancreatic Neuroendocrine Tumor With High-Grade Progression.
Author:	Martin, David R\|LaBauve, Elisa\|Pomo, Joseph M\|Chiu, Vi K\|Hanson, Joshua A\|Gullapalli, Rama R
PMID:	29521944

312.
Journal:	Microb Pathog. 2018 May;118:98-104.
Title:	Gut microbiota and mTOR signaling: Insight on a new pathophysiological interaction.
Author:	Noureldein, Mohamed H\|Eid, Assaad A
PMID:	29548696

313.
Journal:	Biotechnol Appl Biochem. 2018 Mar 25.
Title:	Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells.
Author:	Zhu, Jinhui\|Chen, Yan\|Ji, Yun\|Yu, Yuanquan\|Jin, Yun\|Zhang, Xiaoxiao\|Zhou, Jiale
PMID:	29575133

314.
Journal:	Gland Surg. 2018 Feb;7(1):20-27.
Title:	Management of functional neuroendocrine tumors of the pancreas.
Author:	Oberg, Kjell
PMID:	29629316

315.
Journal:	Diabetes Res Clin Pract. 2018 Sep;143:428-431.
Title:	Everolimus is a new anti-cancer molecule: Metabolic side effects as lipid disorders and hyperglycemia.
Author:	Morviducci, L\|Rota, F\|Rizza, L\|Di Giacinto, P\|Ramponi, S\|Nardone, M R\|Tubili, C\|Lenzi, A\|Zuppi, P\|Baldelli, R
PMID:	29684618

316.
Journal:	Cancers (Basel). 2018 May 14;10(5). pii: cancers10050142.
Title:	A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Author:	Van Sciver, Robert E\|Lee, Michael P\|Lee, Caroline Dasom\|Lafever, Alex C\|Svyatova, Elizaveta\|Kanda, Kevin\|Colliver, Amber L\|Siewertsz van Reesema, Lauren L\|Tang-Tan, Angela M\|Zheleva, Vasilena\|Bwayi, Monicah N\|Bian, Minglei\|Schmidt, Rebecca L\|Matrisian, Ly
PMID:	29757973

317.
Journal:	Oncol Rep. 2018 Jul;40(1):395-404.
Title:	Microarray analysis of circular RNA expression profiles associated with gemcitabine resistance in pancreatic cancer cells.
Author:	Xu, Chao\|Yu, Yue\|Ding, Fei
PMID:	29781033

318.
Journal:	Yonsei Med J. 2018 Aug;59(6):727-735.
Title:	Synergistic Anti-Cancer Effects of AKT and SRC Inhibition in Human Pancreatic Cancer Cells.
Author:	Ahn, Kang\|O, Young Moon\|Ji, Young Geon\|Cho, Han Jun\|Lee, Dong Hyeon
PMID:	29978609

319.
Journal:	Adv Biol Regul. 2018 Aug;69:16-34.
Title:	Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals.
Author:	Abrams, Stephen L\|Lertpiriyapong, Kvin\|Yang, Li V\|Martelli, Alberto M\|Cocco, Lucio\|Ratti, Stefano\|Falasca, Marco\|Murata, Ramiro M\|Rosalen, Pedro L\|Lombardi, Paolo\|Libra, Massimo\|Candido, Saverio\|Montalto, Giuseppe\|Cervello, Melchiorre\|Steelman, Linda S\|Mc
PMID:	29980405

320.
Journal:	Oncol Lett. 2018 Aug;16(2):1937-1942.
Title:	Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway.
Author:	Ye, Yibiao\|Li, Yanshan\|Wei, Yunping\|Xu, Yunxiuxiu\|Wang, Ruomei\|Fu, Zhiqiang\|Zheng, Shangyou\|Zhou, Quanbo\|Zhou, Yu\|Chen, Rufu\|Chen, Tao
PMID:	30008887

321.
Journal:	Endocr Relat Cancer. 2018 Jul 18. pii: ERC-18-0222.
Title:	The IGF pathway is activated in insulinomas but downregulated in metastatic disease.
Author:	Henfling, Mieke\|Perren, Aurel\|Schmitt, Anja Maria\|Saddig, Christiane M\|Starke, Achim A\|Riedl, Robert G\|Versleijen-Jonkers, Yvonne M H\|Sprij-Mooij, Diane M\|Ramaekers, Frans C S\|Hofland, Leo\|Speel, Ernst-Jan M
PMID:	30021864

322.
Journal:	Endocr Relat Cancer. 2018 Jul 18. pii: ERC-18-0120.
Title:	Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms.
Author:	Vandamme, Timon\|Beyens, Matthias\|Boons, Gitta\|Schepers, Anne\|Kamp, Kimberly\|Biermann, Katharina\|Pauwels, Patrick\|de Herder, Wouter W\|Hofland, Leo\|Peeters, Marc\|Van Camp, Guy\|Op de Beeck, Ken
PMID:	30021865

323.
Journal:	Oxid Med Cell Longev. 2018 Jun 26;2018:2798070.
Title:	Mitofusin2 Induces Cell Autophagy of Pancreatic Cancer through Inhibiting the PI3K/Akt/mTOR Signaling Pathway.
Author:	Xue, Ran\|Meng, Qinghua\|Lu, Di\|Liu, Xinjuan\|Wang, Yanbin\|Hao, Jianyu
PMID:	30046371

324.
Journal:	Recent Results Cancer Res. 2018;211:101-123.
Title:	Everolimus.
Author:	Hasskarl, Jens
PMID:	30069763

325.
Journal:	J Nat Prod. 2018 Aug 24;81(8):1877-1883.
Title:	Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.
Author:	Sun, Sijia\|Phrutivorapongkul, Ampai\|Dibwe, Dya Fita\|Balachandran, Chandrasekar\|Awale, Suresh
PMID:	30070833

326.
Journal:	Cancer Biol Ther. 2018 Aug 24:1-13.
Title:	Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody.
Author:	Booth, Laurence\|Roberts, Jane Lisa\|Poklepovic, Andrew\|Dent, Paul
PMID:	30142009

327.
Journal:	Oncol Rep. 2018 Nov;40(5):3102-3111.
Title:	Tanshinone IIA can inhibit MiaPaCa2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways.
Author:	Su, Chin-Cheng
PMID:	30226540

328.
Journal:	Mol Cancer Ther. 2018 Sep 25. pii: 1535-7163.MCT-17-1204.
Title:	A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-Resistant Tumors.
Author:	Chamberlain, Chester E\|German, Michael S\|Yang, Katherine\|Wang, Jason\|VanBrocklin, Henry\|Regan, Melanie\|Shokat, Kevan M\|Ducker, Gregory S\|Kim, Grace E\|Hann, Byron\|Donner, David B\|Warren, Robert S\|Venook, Alan P\|Bergsland, Emily K\|Lee, Danny\|Wang, Yucheng\|N
PMID:	30254185

329.
Journal:	Cancer Biol Ther. 2018 Sep 27:1-10.
Title:	Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-2-regulated apoptosis in pancreatic cancer cells.
Author:	Burmi, Rajpal S\|Maginn, Elaina N\|Gabra, Hani\|Stronach, Euan A\|Wasan, Harpreet S
PMID:	30261145

330.
Journal:	Med Sci Monit. 2018 Oct 1;24:6975-6983.
Title:	Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathway
Author:	Pei, Chenlin\|He, Qun\|Liang, Shuai\|Gong, Xuejun
PMID:	30273298

331.
Journal:	J Nat Prod. 2018 Oct 26;81(10):2282-2291.
Title:	Ancistrolikokine E3, a 5,8'-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway.
Author:	Awale, Suresh\|Dibwe, Dya Fita\|Balachandran, Chandrasekar\|Fayez, Shaimaa\|Feineis, Doris\|Lombe, Blaise Kimbadi\|Bringmann, Gerhard
PMID:	30303002

332.
Journal:	Sci Rep. 2018 Oct 15;8(1):15247.
Title:	Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway.
Author:	Liu, Jiayu\|Song, Nannan\|Huang, Yibing\|Chen, Yuxin
PMID:	30323244

333.
Journal:	Am J Cancer Res. 2018 Sep 1;8(9):1812-1822. eCollection 2018.
Title:	Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer.
Author:	Tian, Yu-Feng\|Wang, Hui-Ching\|Luo, Chi-Wen\|Hung, Wen-Chun\|Lin, Yu-Han\|Chen, Tzu-Yi\|Li, Chien-Feng\|Lin, Chen-Yi\|Pan, Mei-Ren
PMID:	30323973