Literatures

Primary Site >> Liver Cancer

Gene >> MTOR

1.
Journal:	Clin Cancer Res. 2004 Dec 15;10(24):8421-5.
Title:	mTOR and P70 S6 kinase expression in primary liver neoplasms.
Author:	Sahin, Fikret\|Kannangai, Rajesh\|Adegbola, Onikepe\|Wang, Jianzhou\|Su, Gloria\|Torbenson, Michael
PMID:	15623621

2.
Journal:	Semin Liver Dis. 2005;25(2):212-25.
Title:	Hepatocellular carcinoma: molecular pathways and new therapeutic targets.
Author:	Roberts, Lewis R\|Gores, Gregory J
PMID:	15918149

3.
Journal:	J Hepatol. 2005 Dec;43(6):1038-44.
Title:	Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.
Author:	Le Pabic, Helene\|L'Helgoualc'h, Annie\|Coutant, Alexandre\|Wewer, Ulla M\|Baffet, Georges\|Clement, Bruno\|Theret, Nathalie
PMID:	16139919

4.
Journal:	Expert Opin Emerg Drugs. 2006 Sep;11(3):469-87.
Title:	Emerging drugs for hepatocellular carcinoma.
Author:	Roberts, Lewis R\|Gores, Gregory J
PMID:	16939386

5.
Journal:	Mol Carcinog. 2006 Dec;45(12):901-13.
Title:	Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis.
Author:	Yamamoto, Masahiro\|Tamakawa, Susumu\|Yoshie, Masumi\|Yaginuma, Yuji\|Ogawa, Katsuhiro
PMID:	17013836

6.
Journal:	J Hepatol. 2007 May;46(5):840-8.
Title:	Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma.
Author:	Semela, David\|Piguet, Anne-Christine\|Kolev, Mirjam\|Schmitter, Karin\|Hlushchuk, Ruslan\|Djonov, Valentin\|Stoupis, Christoforos\|Dufour, Jean-Francois
PMID:	17321636

7.
Journal:	J Cell Physiol. 2007 Aug;212(2):526-36.
Title:	MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells.
Author:	Bessard, Anne\|Fremin, Christophe\|Ezan, Frederic\|Coutant, Alexandre\|Baffet, Georges
PMID:	17427199

8.
Journal:	Gastroenterol Hepatol. 2007 Jun-Jul;30(6):360-9.
Title:	[Cell biology and genetics in liver cancer].
Author:	Tovar, Victoria\|Villanueva, Augusto\|Llovet, Josep M
PMID:	17662221

9.
Journal:	World J Gastroenterol. 2007 Nov 28;13(44):5845-56.
Title:	Exploiting novel molecular targets in gastrointestinal cancers.
Author:	Ma, Wen W\|Hidalgo, Manuel
PMID:	17990350

10.
Journal:	Curr Pharm Des. 2007;13(32):3279-87.
Title:	Molecular pathways and related target therapies in liver carcinoma.
Author:	Tommasi, S\|Pinto, R\|Pilato, B\|Paradiso, A
PMID:	18045179

11.
Journal:	Oncology. 2007;72 Suppl 1:30-44.
Title:	From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now.
Author:	Pang, Roberta W C\|Poon, Ronnie T P
PMID:	18087180

12.
Journal:	J Cell Biochem. 2008 Apr 1;103(5):1424-37.
Title:	Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells.
Author:	Varma, Shailly\|Khandelwal, Ramji L
PMID:	17721885

13.
Journal:	Cancer Biol Ther. 2008 Mar;7(3):392-6. Epub 2007 Dec 2.
Title:	Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells.
Author:	Bu, Xinxin\|Le, Chen\|Jia, Fengqi\|Guo, Xianling\|Zhang, Li\|Zhang, Baihe\|Wu, Mengchao\|Wei, Lixin
PMID:	18075305

14.
Journal:	J Hepatol. 2008 Jul;49(1):78-87.
Title:	Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma.
Author:	Piguet, Anne-Christine\|Semela, David\|Keogh, Adrian\|Wilkens, Ludwig\|Stroka, Deborah\|Stoupis, Christoforos\|St-Pierre, Marie V\|Dufour, Jean-Francois
PMID:	18486258

15.
Journal:	Mol Cancer Ther. 2008 Aug;7(8):2476-85.
Title:	Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma.
Author:	Longo, Luigia\|Platini, Francesca\|Scardino, Anna\|Alabiso, Oscar\|Vasapollo, Giuseppe\|Tessitore, Luciana
PMID:	18723493

16.
Journal:	Oncol Rep. 2008 Oct;20(4):713-9.
Title:	Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma.
Author:	Li, Wei\|Tan, Dongfeng\|Zhang, Zhaoping\|Liang, John J\|Brown, Robert E
PMID:	18813808

17.
Journal:	Gastroenterology. 2008 Dec;135(6):1972-83, 1983.e1-11.
Title:	Pivotal role of mTOR signaling in hepatocellular carcinoma.
Author:	Villanueva, Augusto\|Chiang, Derek Y\|Newell, Pippa\|Peix, Judit\|Thung, Swan\|Alsinet, Clara\|Tovar, Victoria\|Roayaie, Sasan\|Minguez, Beatriz\|Sole, Manel\|Battiston, Carlo\|Van Laarhoven, Stijn\|Fiel, Maria I\|Di Feo, Analisa\|Hoshida, Yujin\|Yea, Steven\|Toffanin, S
PMID:	18929564

18.
Journal:	J Hepatol. 2008 Dec;49(6):985-97.
Title:	ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft.
Author:	Jasinghe, Viraj J\|Xie, Zhigang\|Zhou, Jianbiao\|Khng, Jiaying\|Poon, Lai-Fong\|Senthilnathan, Palaniyandi\|Glaser, Keith B\|Albert, Daniel H\|Davidsen, Steven K\|Chen, Chien-Shing
PMID:	18930332

19.
Journal:	Transplantation. 2009 Jan 27;87(2):157-63.
Title:	The role of mTOR inhibitors in the management of posttransplant malignancy.
Author:	Monaco, Anthony P
PMID:	19155967

20.
Journal:	Expert Rev Anticancer Ther. 2009 Feb;9(2):247-61.
Title:	mTOR inhibitors for hepatocellular cancer: a forward-moving target.
Author:	Treiber, Gerhard
PMID:	19192962

21.
Journal:	J Cell Mol Med. 2009 Aug;13(8B):2673-83.
Title:	Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma.
Author:	Huynh, Hung\|Ngo, Van Chanh\|Koong, Heng Nung\|Poon, Donald\|Choo, Su Pin\|Thng, Choon Hua\|Chow, Pierce\|Ong, Hock Soo\|Chung, Alexander\|Soo, Khee Chee
PMID:	19220580

22.
Journal:	Rev Med Interne. 2009 May;30(5):416-24.
Title:	[Targeted therapies and their indications in solid neoplasias].
Author:	Dreyer, C\|Raymond, E\|Faivre, S
PMID:	19299048

23.
Journal:	J Cell Biochem. 2009 Jun 1;107(3):408-17.
Title:	Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.
Author:	Chou, Wen-Wen\|Guh, Jinn-Yuh\|Tsai, Jung-Fa\|Hwang, Chi-Ching\|Chiou, Shean-Jaw\|Chuang, Lea-Yea
PMID:	19343784

24.
Journal:	Cancer Res. 2009 May 1;69(9):4059-66.
Title:	Identification of potential driver genes in human liver carcinoma by genomewide screening.
Author:	Woo, Hyun Goo\|Park, Eun Sung\|Lee, Ju-Seog\|Lee, Yun-Han\|Ishikawa, Tsuyoshi\|Kim, Yoon Jun\|Thorgeirsson, Snorri S
PMID:	19366792

25.
Journal:	J Hepatol. 2009 Jun;50(6):1132-41.
Title:	Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.
Author:	Vinciguerra, Manlio\|Carrozzino, Fabio\|Peyrou, Marion\|Carlone, Sebastiano\|Montesano, Roberto\|Benelli, Roberto\|Foti, Michelangelo
PMID:	19398230

26.
Journal:	Biochem Pharmacol. 2009 Jul 1;78(1):21-32.
Title:	Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line.
Author:	Mazzanti, Roberto\|Platini, Francesca\|Bottini, Consuelo\|Fantappie, Ornella\|Solazzo, Michela\|Tessitore, Luciana
PMID:	19447220

27.
Journal:	Hepatology. 2009 Jun;49(6):1962-71.
Title:	Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis.
Author:	Yang, Jui-Chu\|Teng, Chiao-Fang\|Wu, Han-Chieh\|Tsai, Hung-Wen\|Chuang, Huai-Chia\|Tsai, Ting-Fen\|Hsu, Yung-Hsiang\|Huang, Wenya\|Wu, Li-Wha\|Su, Ih-Jen
PMID:	19475690

28.
Journal:	Clin Cancer Res. 2009 Jul 15;15(14):4538-45.
Title:	Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
Author:	Hartmann, Wolfgang\|Kuchler, Jan\|Koch, Arend\|Friedrichs, Nicolaus\|Waha, Anke\|Endl, Elmar\|Czerwitzki, Jacqueline\|Metzger, Dagmar\|Steiner, Susanne\|Wurst, Peter\|Leuschner, Ivo\|von Schweinitz, Dietrich\|Buettner, Reinhard\|Pietsch, Torsten
PMID:	19584164

29.
Journal:	J Hepatol. 2009 Oct;51(4):725-33.
Title:	Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.
Author:	Newell, Pippa\|Toffanin, Sara\|Villanueva, Augusto\|Chiang, Derek Y\|Minguez, Beatriz\|Cabellos, Laia\|Savic, Radoslav\|Hoshida, Yujin\|Lim, Kiat Hon\|Melgar-Lesmes, Pedro\|Yea, Steven\|Peix, Judit\|Deniz, Kemal\|Fiel, M Isabel\|Thung, Swan\|Alsinet, Clara\|Tovar, Victor
PMID:	19665249

30.
Journal:	PLoS One. 2009 Oct 9;4(10):e7373.
Title:	Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines.
Author:	Jimenez, Rosa H\|Boylan, Joan M\|Lee, Ju-Seog\|Francesconi, Mirko\|Castellani, Gastone\|Sanders, Jennifer A\|Gruppuso, Philip A
PMID:	19816606

31.
Journal:	J Hematol Oncol. 2009 Oct 27;2:45.
Title:	Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy.
Author:	Yuan, Ruirong\|Kay, Andrea\|Berg, William J\|Lebwohl, David
PMID:	19860903

32.
Journal:	Org Biomol Chem. 2009 Nov 21;7(22):4651-60.
Title:	Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway.
Author:	Tian, Zhi-yong\|Xie, Song-qiang\|Mei, Zi-hou\|Zhao, Jin\|Gao, Wen-yuan\|Wang, Chao-jie
PMID:	19865701

33.
Journal:	J Hepatol. 2010 Jan;52(1):79-87.
Title:	AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC).
Author:	Huynh, Hung\|Ngo, Van Chanh\|Koong, Heng Nung\|Poon, Donald\|Choo, Su Pin\|Toh, Han Chong\|Thng, Choon Hua\|Chow, Pierce\|Ong, Hock Soo\|Chung, Alexander\|Goh, Boon Cher\|Smith, Paul D\|Soo, Khee Chee
PMID:	19910069

34.
Journal:	Biomed Pharmacother. 2010 Apr;64(4):249-53.
Title:	Involvement of mTOR and survivin inhibition in tamoxifen-induced apoptosis in human hepatoblastoma cell line HepG2.
Author:	Guo, Renhua\|Wang, Tongshan\|Shen, Hua\|Ge, Hong-mei\|Sun, Jing\|Huang, Zu-hu\|Shu, Yong-qian
PMID:	19931998

35.
Journal:	Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):264-9.
Title:	miR-221 overexpression contributes to liver tumorigenesis.
Author:	Pineau, Pascal\|Volinia, Stefano\|McJunkin, Katherine\|Marchio, Agnes\|Battiston, Carlo\|Terris, Benoit\|Mazzaferro, Vincenzo\|Lowe, Scott W\|Croce, Carlo M\|Dejean, Anne
PMID:	20018759

36.
Journal:	Front Biosci (Schol Ed). 2010 Jan 1;2:117-34.
Title:	Molecular and functional genetics of hepatocellular carcinoma.
Author:	Yam, Judy Wai Ping\|Wong, Chun Ming\|Ng, Irene Oi-Lin
PMID:	20036934

37.
Journal:	Hepatology. 2010 Feb;51(2):557-66.
Title:	Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis.
Author:	Pelletier, Laura\|Rebouissou, Sandra\|Paris, Alain\|Rathahao-Paris, Estelle\|Perdu, Elisabeth\|Bioulac-Sage, Paulette\|Imbeaud, Sandrine\|Zucman-Rossi, Jessica
PMID:	20041408

38.
Journal:	Expert Opin Investig Drugs. 2010 Feb;19(2):265-74.
Title:	Targeted therapy of hepatocellular cancer.
Author:	Wysocki, Piotr Jan
PMID:	20074016

39.
Journal:	Cancer. 2010 Mar 1;116(5):1315-25.
Title:	AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma.
Author:	Huynh, Hung
PMID:	20101735

40.
Journal:	Am J Transl Res. 2010 Jan 23;2(1):105-18.
Title:	Molecular genetics of hepatocellular neoplasia.
Author:	Jain, Shilpa\|Singhal, Shashideep\|Lee, Peng\|Xu, Ruliang
PMID:	20182587

41.
Journal:	Mol Pharmacol. 2010 Jun;77(6):1025-36.
Title:	EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway.
Author:	Ji, Ruyue\|Chou, Chih-Ling\|Xu, Wei\|Chen, Xiao-Bo\|Woodward, David F\|Regan, John W
PMID:	20335389

42.
Journal:	J Hepatol. 2010 May;52(5):771-5.
Title:	Personalized molecular targeted therapy in advanced, recurrent hepatocellular carcinoma after liver transplantation: a proof of principle.
Author:	Bhoori, Sherrie\|Toffanin, Sara\|Sposito, Carlo\|Germini, Alessandro\|Pellegrinelli, Alessandro\|Lampis, Andrea\|Mazzaferro, Vincenzo
PMID:	20347502

43.
Journal:	Biochem Pharmacol. 2010 Sep 1;80(5):550-60.
Title:	Molecularly targeted therapy in hepatocellular carcinoma.
Author:	Huynh, Hung
PMID:	20371362

44.
Journal:	J Hepatol. 2010 Jun;52(6):921-9.
Title:	Cancer gene discovery in hepatocellular carcinoma.
Author:	Zender, Lars\|Villanueva, Augusto\|Tovar, Victoria\|Sia, Daniela\|Chiang, Derek Y\|Llovet, Josep M
PMID:	20385424

45.
Journal:	Aliment Pharmacol Ther. 2010 Sep;32(6):763-8.
Title:	Pilot study: rapamycin in advanced hepatocellular carcinoma.
Author:	Schoniger-Hekele, M\|Muller, C
PMID:	20629977

46.
Journal:	Oncogene. 2010 Sep 9;29(36):4989-5005.
Title:	The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
Author:	Whittaker, S\|Marais, R\|Zhu, A X
PMID:	20639898

47.
Journal:	PLoS One. 2010 Jul 15;5(7):e11607.
Title:	DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism.
Author:	Wang, Ying\|Gao, Wenli\|Svitkin, Yuri V\|Chen, Annie Pei-Chun\|Cheng, Yung-Chi
PMID:	20657652

48.
Journal:	J Cell Biochem. 2010 Dec 15;111(6):1426-36.
Title:	Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism.
Author:	Wang, Ning\|Feng, Yibin\|Zhu, Meifen\|Tsang, Chi-Man\|Man, Kwan\|Tong, Yao\|Tsao, Sai-Wah
PMID:	20830746

49.
Journal:	Orv Hetil. 2010 Oct 24;151(43):1763-8.
Title:	[New possibilities of targeted therapy in the treatment of hepatocellular carcinoma with the help of molecular biology].
Author:	Hagymasi, Krisztina\|Tulassay, Zsolt
PMID:	20940115

50.
Journal:	Nutr Res Pract. 2010 Oct;4(5):351-5.
Title:	Significance of p27 as potential biomarker for intracellular oxidative status.
Author:	Quintos, Lesley\|Lee, In Ae\|Kim, Hyo Jung\|Lim, Ji-Sun\|Park, Jia\|Sung, Mi-Kyung\|Seo, Young Rok\|Kim, Jong-Sang
PMID:	21103079

51.
Journal:	Anticancer Res. 2010 Dec;30(12):4951-8.
Title:	PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways.
Author:	Gedaly, Roberto\|Angulo, Paul\|Hundley, Jonathan\|Daily, Michael F\|Chen, Changguo\|Koch, Alvaro\|Evers, B Mark
PMID:	21187475

52.
Journal:	Zhonghua Zhong Liu Za Zhi. 2010 Dec;32(12):903-6.
Title:	[Down-regulation of mTOR activity and survivin expression during tamoxifen-induced apoptosis in hepatoblastoma cells].
Author:	Guo, Ren-Hua\|Wang, Tong-Shan\|Chen, Xiao-Feng\|Huang, Zu-Hu\|Shu, Yong-Qian
PMID:	21223797

53.
Journal:	Invest New Drugs. 2011 Dec;29(6):1177-87.
Title:	Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1alpha expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells.
Author:	Weng, Qinjie\|Zhang, Jun\|Cao, Ji\|Xia, Qing\|Wang, Duoduo\|Hu, Yongzhou\|Sheng, Rong\|Wu, Honghai\|Zhu, Difeng\|Zhu, Hong\|He, Qiaojun\|Yang, Bo
PMID:	20524035

54.
Journal:	Apoptosis. 2011 Jan;16(1):27-34.
Title:	NPC-16, a novel naphthalimide-polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells.
Author:	Xie, Song-qiang\|Li, Qian\|Zhang, Ya-hong\|Wang, Jian-hong\|Mei, Zi-hou\|Zhao, Jin\|Wang, Chao-jie
PMID:	20809291

55.
Journal:	Int J Oncol. 2011 Mar;38(3):713-20.
Title:	beta-hydroxy-beta-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia.
Author:	Aversa, Zaira\|Bonetto, Andrea\|Costelli, Paola\|Minero, Valerio Giacomo\|Penna, Fabio\|Baccino, Francesco Maria\|Lucia, Simone\|Rossi Fanelli, Filippo\|Muscaritoli, Maurizio
PMID:	21184031

56.
Journal:	Diabetologia. 2011 Apr;54(4):954-64.
Title:	Oleate-mediated activation of phospholipase D and mammalian target of rapamycin (mTOR) regulates proliferation and rapamycin sensitivity of hepatocarcinoma cells.
Author:	Arous, C\|Naimi, M\|Van Obberghen, E
PMID:	21240477

57.
Journal:	Arch Biochem Biophys. 2011 Apr 15;508(2):204-11.
Title:	Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma.
Author:	Byekova, Yevgeniya A\|Herrmann, Jennifer L\|Xu, Jianmin\|Elmets, Craig A\|Athar, Mohammad
PMID:	21272562

58.
Journal:	Alcohol Clin Exp Res. 2011 May;35(5):821-5.
Title:	Molecular pathogenesis of hepatocellular carcinoma.
Author:	Cornella, Helena\|Alsinet, Clara\|Villanueva, Augusto
PMID:	21303380

59.
Journal:	Cancer Res. 2011 Jul 15;71(14):4955-67.
Title:	Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
Author:	Bareford, M Danielle\|Park, Margaret A\|Yacoub, Adly\|Hamed, Hossein A\|Tang, Yong\|Cruickshanks, Nichola\|Eulitt, Patrick\|Hubbard, Nisan\|Tye, Gary\|Burow, Matthew E\|Fisher, Paul B\|Moran, Richard G\|Nephew, Kenneth P\|Grant, Steven\|Dent, Paul
PMID:	21622715

60.
Journal:	J Hepatol. 2011 Dec;55(6):1400-8.
Title:	Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.
Author:	Kudo, Yotaro\|Tanaka, Yasuo\|Tateishi, Keisuke\|Yamamoto, Keisuke\|Yamamoto, Shinzo\|Mohri, Dai\|Isomura, Yoshihiro\|Seto, Motoko\|Nakagawa, Hayato\|Asaoka, Yoshinari\|Tada, Motohisa\|Ohta, Miki\|Ijichi, Hideaki\|Hirata, Yoshihiro\|Otsuka, Motoyuki\|Ikenoue, Tsuneo\|Maed
PMID:	21703185

61.
Journal:	Autophagy. 2011 Oct;7(10):1261-2.
Title:	Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
Author:	Bareford, M Danielle\|Hamed, Hossein A\|Tang, Yong\|Cruickshanks, Nichola\|Burow, Matthew E\|Fisher, Paul B\|Moran, Richard G\|Nephew, Kenneth P\|Grant, Steven\|Dent, Paul
PMID:	21814046

62.
Journal:	Dig Dis. 2011;29(3):273-7.
Title:	Molecular targeted therapy for hepatocellular carcinoma: bench to bedside.
Author:	Kudo, Masatoshi
PMID:	21829017

63.
Journal:	Dig Dis. 2011;29(3):310-5.
Title:	mTOR inhibitor for the treatment of hepatocellular carcinoma.
Author:	Kudo, Masatoshi
PMID:	21829022

64.
Journal:	Curr Cancer Drug Targets. 2011 Oct;11(8):929-43.
Title:	L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of beta-catenin-mutated human hepatocellular carcinoma cells.
Author:	Tardito, S\|Chiu, M\|Uggeri, J\|Zerbini, A\|Da Ros, F\|Dall'Asta, V\|Missale, G\|Bussolati, O
PMID:	21834755

65.
Journal:	Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15201-6.
Title:	The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.
Author:	Wang, Beatrice T\|Ducker, Gregory S\|Barczak, Andrea J\|Barbeau, Rebecca\|Erle, David J\|Shokat, Kevan M
PMID:	21876130

66.
Journal:	BMC Cancer. 2011 Oct 5;11:427.
Title:	HNF1alpha inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines.
Author:	Pelletier, Laura\|Rebouissou, Sandra\|Vignjevic, Danijela\|Bioulac-Sage, Paulette\|Zucman-Rossi, Jessica
PMID:	21975049

67.
Journal:	Future Oncol. 2011 Oct;7(10):1149-67.
Title:	Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma.
Author:	Zhou, Qian\|Lui, Vivian W Y\|Yeo, Winnie
PMID:	21992728

68.
Journal:	Drugs Today (Barc). 2011 Oct;47(10):773-86.
Title:	Current treatment options for neuroendocrine tumors.
Author:	Horsch, D\|Grabowski, P\|Schneider, C P\|Petrovitch, A\|Kaemmerer, D\|Hommann, M\|Baum, R P
PMID:	22076492

69.
Journal:	Orv Hetil. 2011 Dec 4;152(49):1955-61.
Title:	[Role of autophagy in the pathogenesis of liver diseases].
Author:	Werling, Klara
PMID:	22106162

70.
Journal:	J Hepatol. 2012 Jan;56(1):176-83.
Title:	Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo.
Author:	Shao, Huanjie\|Gao, Chun\|Tang, Haikuo\|Zhang, Hao\|Roberts, Lewis R\|Hylander, Bonnie L\|Repasky, Elizabeth A\|Ma, Wen W\|Qiu, Jingxin\|Adjei, Alex A\|Dy, Grace K\|Yu, Chunrong
PMID:	21835141

71.
Journal:	Dis Model Mech. 2012 Jan;5(1):63-72.
Title:	An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening.
Author:	Nguyen, Anh Tuan\|Emelyanov, Alexander\|Koh, Chor Hui Vivien\|Spitsbergen, Jan M\|Parinov, Serguei\|Gong, Zhiyuan
PMID:	21903676

72.
Journal:	Hepatology. 2012 Mar;55(3):833-45.
Title:	AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,
Author:	Ho, Coral\|Wang, Chunmei\|Mattu, Sandra\|Destefanis, Giulia\|Ladu, Sara\|Delogu, Salvatore\|Armbruster, Julia\|Fan, Lingling\|Lee, Susie A\|Jiang, Lijie\|Dombrowski, Frank\|Evert, Matthias\|Chen, Xin\|Calvisi, Diego F
PMID:	21993994

73.
Journal:	Cancer Lett. 2012 Mar 28;316(2):187-95.
Title:	HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway.
Author:	Jung, Kyung Hee\|Choi, Myung-Joo\|Hong, Seunghee\|Lee, Hyunseung\|Hong, Sang-Won\|Zheng, Hong-Mei\|Lee, Hee-Seung\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	22182943

74.
Journal:	J Biol Chem. 2012 Feb 10;287(7):5042-58.
Title:	Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.
Author:	George, Anju\|Panda, Swarupa\|Kudmulwar, Devika\|Chhatbar, Salma Pathan\|Nayak, Sanjeev Chavan\|Krishnan, Harinivas Harshan
PMID:	22184107

75.
Journal:	Int Immunopharmacol. 2012 Feb;12(2):394-401.
Title:	Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival.
Author:	Liu, Chang\|Jia, Zhiling\|Zhang, Xia\|Hou, Jincai\|Wang, Li\|Hao, Shuling\|Ruan, Xinjian\|Yu, Zhonghe\|Zheng, Yongqiu
PMID:	22222116

76.
Journal:	J Surg Res. 2012 Aug;176(2):542-8.
Title:	PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation.
Author:	Gedaly, Roberto\|Angulo, Paul\|Hundley, Jonathan\|Daily, Michael F\|Chen, Changguo\|Evers, B Mark
PMID:	22261591

77.
Journal:	Hepatology. 2012 May;55(5):1473-84.
Title:	V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis.
Author:	Evert, Matthias\|Calvisi, Diego F\|Evert, Katja\|De Murtas, Valentina\|Gasparetti, Gioia\|Mattu, Sandra\|Destefanis, Giulia\|Ladu, Sara\|Zimmermann, Antje\|Delogu, Salvatore\|Thiel, Sara\|Thiele, Andrea\|Ribback, Silvia\|Dombrowski, Frank
PMID:	22271091

78.
Journal:	Apoptosis. 2012 Jul;17(7):725-34.
Title:	3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway.
Author:	Xie, Song-qiang\|Zhang, Ya-hong\|Li, Qian\|Xu, Feng-hua\|Miao, Jiu-wang\|Zhao, Jin\|Wang, Chao-jie
PMID:	22395446

79.
Journal:	Sci Signal. 2012 Mar 27;5(217):ra24.
Title:	Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
Author:	Menon, Suchithra\|Yecies, Jessica L\|Zhang, Hui H\|Howell, Jessica J\|Nicholatos, Justin\|Harputlugil, Eylul\|Bronson, Roderick T\|Kwiatkowski, David J\|Manning, Brendan D
PMID:	22457330

80.
Journal:	Dig Liver Dis. 2012 Jul;44(7):610-6.
Title:	Phase II study of sirolimus in treatment-naive patients with advanced hepatocellular carcinoma.
Author:	Decaens, Thomas\|Luciani, Alain\|Itti, Emmanuel\|Hulin, Anne\|Roudot-Thoraval, Francoise\|Laurent, Alexis\|Zafrani, Elie Serge\|Mallat, Ariane\|Duvoux, Christophe
PMID:	22459565

81.
Journal:	Exp Mol Pathol. 2012 Aug;93(1):40-9.
Title:	The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.
Author:	Sanders, Jennifer A\|Brilliant, Kate E\|Clift, Danielle\|Patel, Ajay\|Cerretti, Bruno\|Claro, Patricia\|Mills, David R\|Hixson, Douglas C\|Gruppuso, Philip A
PMID:	22525806

82.
Journal:	BMC Cancer. 2012 May 4;12:166.
Title:	Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model.
Author:	Wang, Cun\|Gao, Dongmei\|Guo, Kun\|Kang, Xiaonan\|Jiang, Kai\|Sun, Chun\|Li, Yan\|Sun, Lu\|Shu, Hong\|Jin, Guangzhi\|Sun, Haiyan\|Wu, Weizhong\|Liu, Yinkun
PMID:	22559167

83.
Journal:	Cell Signal. 2012 Aug;24(8):1722-32.
Title:	Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling.
Author:	Zou, Meijuan\|Lu, Na\|Hu, Chen\|Liu, Wei\|Sun, Yajing\|Wang, Xiaotang\|You, Qidong\|Gu, Cong\|Xi, Tao\|Guo, Qinglong
PMID:	22560876

84.
Journal:	Cancer Res. 2012 Jul 1;72(13):3360-71.
Title:	The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.
Author:	Luo, Zhongguang\|Yu, Guangyang\|Lee, Hyuk Woo\|Li, Lihui\|Wang, Lingyan\|Yang, Dongqin\|Pan, Yongfu\|Ding, Chan\|Qian, Jing\|Wu, Lijun\|Chu, Yiwei\|Yi, Jing\|Wang, Xiangdong\|Sun, Yi\|Jeong, Lak Shin\|Liu, Jie\|Jia, Lijun
PMID:	22562464

85.
Journal:	Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Feb;33(2):215-9.
Title:	[Association of genetic polymorphisms of key molecules in JAK/STAT signaling pathway with susceptibility of hepatocellular carcinoma].
Author:	Xie, Jia-xin\|Yin, Jian-hua\|Zhang, Qi\|Pu, Rui\|Zhang, Yu-wei\|Lu, Wen-ying\|Cao, Guang-wen
PMID:	22575147

86.
Journal:	J Cell Biochem. 2012 Oct;113(10):3113-21.
Title:	Branched-chain amino acid deficiency stabilizes insulin-induced vascular endothelial growth factor mRNA in hepatocellular carcinoma cells.
Author:	Miuma, Satoshi\|Ichikawa, Tatsuki\|Arima, Kazuhiko\|Takeshita, Shigeyuki\|Muraoka, Toru\|Matsuzaki, Toshihisa\|Ootani, Masashi\|Shibata, Hidetaka\|Akiyama, Motohisa\|Ozawa, Eisuke\|Miyaaki, Hisamitsu\|Taura, Naota\|Takeshima, Fuminao\|Nakao, Kazuhiko
PMID:	22581719

87.
Journal:	Mol Cancer Res. 2012 Jul;10(7):979-91.
Title:	Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFbeta tumor suppressor signaling pathways.
Author:	Jung, Christine J\|Iyengar, Sushma\|Blahnik, Kimberly R\|Jiang, Joy X\|Tahimic, Candice\|Torok, Natalie J\|de vere White, Ralph W\|Farnham, Peggy J\|Zern, Mark
PMID:	22622027

88.
Journal:	Curr Med Chem. 2012;19(22):3722-9.
Title:	Hepatocellular carcinoma: important biomarkers and their significance in molecular diagnostics and therapy.
Author:	Sengupta, B\|Siddiqi, S A
PMID:	22680921

89.
Journal:	Gynecol Oncol. 2012 Oct;127(1):249-55.
Title:	Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.
Author:	Xiao, Xuxian\|He, Qiongqiong\|Lu, Changming\|Werle, Kaitlin D\|Zhao, Rui-Xun\|Chen, Jianfeng\|Davis, Ben C\|Cui, Rutao\|Liang, Jiyong\|Xu, Zhi-Xiang
PMID:	22735790

90.
Journal:	Anticancer Res. 2012 Jul;32(7):2531-6.
Title:	The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment.
Author:	Gedaly, Roberto\|Angulo, Paul\|Chen, Changguo\|Creasy, Kate Townsend\|Spear, Brett T\|Hundley, Jonathan\|Daily, Michael F\|Shah, Malay\|Evers, B Mark
PMID:	22753710

91.
Journal:	Int J Oncol. 2012 Oct;41(4):1431-42.
Title:	Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells.
Author:	Tsai, Shih-Chang\|Yang, Jai-Sing\|Peng, Shu-Fen\|Lu, Chi-Cheng\|Chiang, Jo-Hua\|Chung, Jing-Gung\|Lin, Meng-Wei\|Lin, Jen-Kun\|Amagaya, Sakae\|Wai-Shan Chung, Cinderella\|Tung, Theng-Thang\|Huang, Wen-Wen\|Tseng, Michael T
PMID:	22858649

92.
Journal:	J Agric Food Chem. 2012 Aug 29;60(34):8363-71.
Title:	Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells.
Author:	Chu, Yung-Lin\|Ho, Chi-Tang\|Chung, Jing-Gung\|Rajasekaran, Raghu\|Sheen, Lee-Yan
PMID:	22860996

93.
Journal:	Curr Cancer Drug Targets. 2012 Nov 1;12(9):1045-61.
Title:	mTor as a potential target for the prevention and treatment of hepatocellular carcinoma.
Author:	Buitrago-Molina, Laura Elisa\|Vogel, Arndt
PMID:	22873368

94.
Journal:	Hepatology. 2012 Dec;56(6):2255-67.
Title:	Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.
Author:	Wu, Kun\|Ding, Jin\|Chen, Cheng\|Sun, Wen\|Ning, Bei-Fang\|Wen, Wen\|Huang, Lei\|Han, Tao\|Yang, Wen\|Wang, Chao\|Li, Zhong\|Wu, Meng-Chao\|Feng, Gen-Sheng\|Xie, Wei-Fen\|Wang, Hong-Yang
PMID:	22898879

95.
Journal:	Cancer Sci. 2012 Nov;103(11):1929-37.
Title:	SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway.
Author:	Hong, Sang-Won\|Jung, Kyung Hee\|Lee, Hee-Seung\|Choi, Myung-Joo\|Son, Mi Kwon\|Zheng, Hong-Mei\|Hong, Soon-Sun
PMID:	22909393

96.
Journal:	Clin Cancer Res. 2012 Oct 15;18(20):5662-71.
Title:	Sorafenib inhibits hypoxia-inducible factor-1alpha synthesis: implications for antiangiogenic activity in hepatocellular carcinoma.
Author:	Liu, Li-ping\|Ho, Rocky L K\|Chen, George G\|Lai, Paul B S
PMID:	22929805

97.
Journal:	Biochem Biophys Res Commun. 2012 Sep 21;426(2):247-52.
Title:	MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA.
Author:	Lang, Qingbo\|Ling, Changquan
PMID:	22940133

98.
Journal:	Autophagy. 2012 Dec;8(12):1856-8.
Title:	Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis.
Author:	Yang, Dongqin\|Zhao, Yongchao\|Liu, Jie\|Sun, Yi\|Jia, Lijun
PMID:	22965024

99.
Journal:	Asian Pac J Cancer Prev. 2012;13(7):3275-9.
Title:	Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway.
Author:	Xiong, Yu\|Lu, Qing-Jun\|Zhao, Jing\|Wu, Guo-Yang
PMID:	22994747

100.
Journal:	Int J Mol Med. 2012 Dec;30(6):1321-6.
Title:	microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma.
Author:	Zhu, Xu-Chao\|Dong, Qiong-Zhu\|Zhang, Xiao-Fei\|Deng, Biao\|Jia, Hu-Liang\|Ye, Qin-Hai\|Qin, Lun-Xiu\|Wu, Xing-Zhong
PMID:	23023935

101.
Journal:	PLoS One. 2012;7(10):e47053.
Title:	MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R.
Author:	Wang, Biyun\|Wang, Hong\|Yang, Ziang
PMID:	23056576

102.
Journal:	Hepat Mon. 2012 Oct;12(10 HCC):e7492.
Title:	The Predictive and Prognostic Significance of c-erb-B2, EGFR, PTEN, mTOR, PI3K, p27, and ERCC1 Expression in Hepatocellular Carcinoma.
Author:	Bassullu, Nuray\|Turkmen, Ilknur\|Dayangac, Murat\|Yagiz Korkmaz, Pinar\|Yasar, Reyhan\|Akyildiz, Murat\|Yaprak, Onur\|Tokat, Yaman\|Yuzer, Yildiray\|Bulbul Dogusoy, Gulen
PMID:	23162604

103.
Journal:	Mol Cancer. 2012 Nov 20;11:85.
Title:	Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells.
Author:	Grabinski, Nicole\|Ewald, Florian\|Hofmann, Bianca T\|Staufer, Katharina\|Schumacher, Udo\|Nashan, Bjorn\|Jucker, Manfred
PMID:	23167739

104.
Journal:	Expert Rev Anticancer Ther. 2012 Oct;12(10):1347-57.
Title:	Pathways and targets in hepatocellular carcinoma.
Author:	Psyrri, Amanda\|Arkadopoulos, Nikolaos\|Vassilakopoulou, Maria\|Smyrniotis, Vassilios\|Dimitriadis, George
PMID:	23176622

105.
Journal:	Liver Cancer. 2012 Sep;1(2):83-93.
Title:	Emerging signaling pathways in hepatocellular carcinoma.
Author:	Moeini, Agrin\|Cornella, Helena\|Villanueva, Augusto
PMID:	24159576

106.
Journal:	Hepatology. 2013 Jan;57(1):205-16.
Title:	Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice.
Author:	Sun, Xiaofeng\|Han, Lihui\|Seth, Pankaj\|Bian, Shu\|Li, Linglin\|Csizmadia, Eva\|Junger, Wolfgang G\|Schmelzle, Moritz\|Usheva, Anny\|Tapper, Elliot B\|Baffy, Gyorgy\|Sukhatme, Vikas P\|Wu, Yan\|Robson, Simon C
PMID:	22859060

107.
Journal:	Cancer Lett. 2013 Jan 1;328(1):176-87.
Title:	Suppression of tumor proliferation and angiogenesis of hepatocellular carcinoma by HS-104, a novel phosphoinositide 3-kinase inhibitor.
Author:	Jung, Kyung Hee\|Zheng, Hong-Mei\|Jeong, Yujeong\|Choi, Myung-Joo\|Lee, Hyunseung\|Hong, Sang-Won\|Lee, Hee-Seung\|Son, Mi Kwon\|Lee, Soyoung\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	22902995

108.
Journal:	Mol Cell Biochem. 2013 Jan;372(1-2):161-8.
Title:	HBx induces HepG-2 cells autophagy through PI3K/Akt-mTOR pathway.
Author:	Wang, Peng\|Guo, Qing-Song\|Wang, Zhi-Wei\|Qian, Hai-Xin
PMID:	23001846

109.
Journal:	Curr Cancer Drug Targets. 2013 Mar;13(3):300-12.
Title:	Targeting tyrosine kinase receptors in hepatocellular carcinoma.
Author:	Muntane, Jordi\|De la Rosa, Angel J\|Docobo, Fernando\|Garcia-Carbonero, Rocio\|Padillo, Francisco J
PMID:	23016985

110.
Journal:	Anticancer Drugs. 2013 Jan;24(1):32-42.
Title:	Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro.
Author:	Li, Ming\|Li, Qian\|Zhang, Ya-Hong\|Tian, Zhi-Yong\|Ma, Hong-Xia\|Zhao, Jin\|Xie, Song-Qiang\|Wang, Chao-Jie
PMID:	23032518

111.
Journal:	Curr Pharm Des. 2013;19(7):1192-200.
Title:	Epigenetic deregulation of microRNAs: new opportunities to target oncogenic signaling pathways in hepatocellular carcinoma.
Author:	Yu, Zhuo\|Cheng, Alfred Sze-Lok
PMID:	23092339

112.
Journal:	Cancer Lett. 2013 Feb 1;329(1):99-108.
Title:	IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma.
Author:	Lee, Ju-Hee\|Lee, Hyunseung\|Yun, Sun-Mi\|Jung, Kyung Hee\|Jeong, Yujeong\|Yan, Hong Hua\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	23142281

113.
Journal:	Exp Cell Res. 2013 Feb 15;319(4):474-86.
Title:	Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling.
Author:	Mathew, Jasmin\|Loranger, Anne\|Gilbert, Stephane\|Faure, Robert\|Marceau, Normand
PMID:	23164509

114.
Journal:	J Clin Invest. 2013 Feb;123(2):630-45.
Title:	Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.
Author:	Xu, Xiaojie\|Fan, Zhongyi\|Kang, Lei\|Han, Juqiang\|Jiang, Chengying\|Zheng, Xiaofei\|Zhu, Ziman\|Jiao, Huabo\|Lin, Jing\|Jiang, Kai\|Ding, Lihua\|Zhang, Hao\|Cheng, Long\|Fu, Hanjiang\|Song, Yi\|Jiang, Ying\|Liu, Jiahong\|Wang, Rongfu\|Du, Nan\|Ye, Qinong
PMID:	23321675

115.
Journal:	Phytother Res. 2013 Nov;27(11):1714-22.
Title:	Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 beta mediate ursolic acid induced apoptosis in HepG2 liver cancer cells.
Author:	Son, Hyun-Soo\|Kwon, Hee Young\|Sohn, Eun Jung\|Lee, Jang-Hoon\|Woo, Hong-Jung\|Yun, Miyong\|Kim, Sung-Hoon\|Kim, Young-Chul
PMID:	23325562

116.
Journal:	Anticancer Drugs. 2013 Apr;24(4):415-21.
Title:	Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
Author:	Coulter, Don W\|Walko, Christine\|Patel, Jai\|Moats-Staats, Billie M\|McFadden, Andrew\|Smith, Scott V\|Khan, Wasiuddin A\|Bridges, Arlene S\|Deal, Allison M\|Oesterheld, Javier\|Davis, Ian J\|Blatt, Julie
PMID:	23328074

117.
Journal:	Int J Mol Sci. 2013 Jan 11;14(1):1370-82.
Title:	Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy.
Author:	Miao, Qing\|Bi, Lin-Lin\|Li, Xin\|Miao, Shan\|Zhang, Jin\|Zhang, Song\|Yang, Qian\|Xie, Yan-Hua\|Zhang, Jian\|Wang, Si-Wang
PMID:	23344047

118.
Journal:	J Hepatol. 2013 Jun;58(6):1147-56.
Title:	Molecular and metabolic changes in human liver clear cell foci resemble the alterations occurring in rat hepatocarcinogenesis.
Author:	Ribback, Silvia\|Calvisi, Diego F\|Cigliano, Antonio\|Sailer, Verena\|Peters, Michele\|Rausch, Jenny\|Heidecke, Claus-Dieter\|Birth, Matthias\|Dombrowski, Frank
PMID:	23348238

119.
Journal:	Cell Death Dis. 2013 Feb 7;4:e489.
Title:	The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.
Author:	Cheng, P\|Ni, Z\|Dai, X\|Wang, B\|Ding, W\|Rae Smith, A\|Xu, L\|Wu, D\|He, F\|Lian, J
PMID:	23392177

120.
Journal:	Hepatology. 2013 Aug;58(2):810-8.
Title:	The mTOR pathway in hepatic malignancies.
Author:	Bhat, Mamatha\|Sonenberg, Nahum\|Gores, Gregory J
PMID:	23408390

121.
Journal:	Cancer Chemother Pharmacol. 2013 May;71(5):1297-307.
Title:	Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib.
Author:	Serova, Maria\|de Gramont, Armand\|Tijeras-Raballand, Annemilai\|Dos Santos, Celia\|Riveiro, Maria Eugenia\|Slimane, Khemaies\|Faivre, Sandrine\|Raymond, Eric
PMID:	23479136

122.
Journal:	Liver Int. 2013 May;33(5):780-93.
Title:	Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.
Author:	Kirstein, Martha M\|Boukouris, Aristeidis E\|Pothiraju, Deepika\|Buitrago-Molina, Laura E\|Marhenke, Silke\|Schutt, Jutta\|Orlik, Johanna\|Kuhnel, Florian\|Hegermann, Jan\|Manns, Michael P\|Vogel, Arndt
PMID:	23489999

123.
Journal:	J Hepatol. 2013 Jul;59(1):59-66.
Title:	Comparative efficacy of sorafenib versus best supportive care in recurrent hepatocellular carcinoma after liver transplantation: a case-control study.
Author:	Sposito, Carlo\|Mariani, Luigi\|Germini, Alessandro\|Flores Reyes, Maria\|Bongini, Marco\|Grossi, Glenda\|Bhoori, Sherrie\|Mazzaferro, Vincenzo
PMID:	23500153

124.
Journal:	Cancer Cell Int. 2013 Mar 28;13:30.
Title:	The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells.
Author:	Li, Shuyu\|Liang, Yan\|Wu, Manlin\|Wang, Xiaojing\|Fu, Haixia\|Chen, Yuhao\|Wang, Zhigang
PMID:	23537100

125.
Journal:	BMC Cancer. 2013 Apr 15;13:191.
Title:	Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma.
Author:	Honda, Masao\|Yamashita, Taro\|Yamashita, Tatsuya\|Arai, Kuniaki\|Sakai, Yoshio\|Sakai, Akito\|Nakamura, Mikiko\|Mizukoshi, Eishiro\|Kaneko, Shuichi
PMID:	23587162

126.
Journal:	Int J Oncol. 2013 Jul;43(1):201-9.
Title:	Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor.
Author:	Yun, Sun-Mi\|Lee, Ju-Hee\|Jung, Kyung Hee\|Lee, Hyunseung\|Lee, Soyoung\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	23604199

127.
Journal:	Toxicol Lett. 2013 Jul 4;220(2):150-6.
Title:	PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells.
Author:	Wang, Feng-Ze\|Peng-Jiao\|Yang, Na-Na\|Chuang-Yuan\|Zhao, Ya-Li\|Liu, Qiang-Qiang\|Fei, Hong-Rong\|Zhang, Ji-Guo
PMID:	23639247

128.
Journal:	Eur J Pharmacol. 2013 Aug 15;714(1-3):261-73.
Title:	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis.
Author:	Zeng, Ke-Wu\|Li, Ning\|Dong, Xin\|Ma, Zhi-Zhong\|Jiang, Yong\|Jin, Hong-Wei\|Tu, Peng-Fei
PMID:	23684542

129.
Journal:	BMC Cancer. 2013 May 30;13:267.
Title:	Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells.
Author:	Chang, Alex Y\|Wang, Miao
PMID:	23721490

130.
Journal:	J Biol Chem. 2013 Jul 19;288(29):21341-50.
Title:	The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (alpha4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A.
Author:	Du, Haijuan\|Huang, Yongzhao\|Zaghlula, Manar\|Walters, Erica\|Cox, Timothy C\|Massiah, Michael A
PMID:	23740247

131.
Journal:	Cell Cycle. 2013 Jul 1;12(13):1999-2010.
Title:	Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: implications for the treatment of human liver cancer.
Author:	Wang, Chunmei\|Cigliano, Antonio\|Delogu, Salvatore\|Armbruster, Julia\|Dombrowski, Frank\|Evert, Matthias\|Chen, Xin\|Calvisi, Diego F
PMID:	23759595

132.
Journal:	J Surg Res. 2013 Nov;185(1):225-30.
Title:	PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation.
Author:	Gedaly, Roberto\|Galuppo, Roberto\|Musgrave, Yolanda\|Angulo, Paul\|Hundley, Jonathan\|Shah, Malay\|Daily, Michael F\|Chen, Changguo\|Cohen, Donald A\|Spear, Brett T\|Evers, B Mark
PMID:	23769634

133.
Journal:	PLoS One. 2013 Jun 13;8(6):e64260.
Title:	Actionable gene expression-based patient stratification for molecular targeted therapy in hepatocellular carcinoma.
Author:	Kwon, Jung-Hee\|Lee, Namgyu\|Park, Jin Young\|Yu, Yun Suk\|Kim, Jin Pyo\|Shin, Ji Hye\|Kim, Dong-Sik\|Joh, Jae Won\|Kim, Dae Shick\|Choi, Kwan Yong\|Kang, Koo-Jeong\|Kim, Gundo\|Moon, Young Ho\|Wang, Hee Jung
PMID:	23785399

134.
Journal:	Mol Cancer Ther. 2013 Sep;12(9):1796-804.
Title:	Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling.
Author:	Wen, Wen\|Han, Tao\|Chen, Cheng\|Huang, Lei\|Sun, Wen\|Wang, Xue\|Chen, Shu-Zhen\|Xiang, Dai-Min\|Tang, Liang\|Cao, Dan\|Feng, Gen-Sheng\|Wu, Meng-Chao\|Ding, Jin\|Wang, Hong-Yang
PMID:	23804702

135.
Journal:	Curr Diabetes Rev. 2013 Sep;9(5):382-6.
Title:	The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives.
Author:	Facciorusso, Antonio
PMID:	23845075

136.
Journal:	Eur J Surg Oncol. 2013 Sep;39(9):974-80.
Title:	Prognostic impact of pERK in advanced hepatocellular carcinoma patients treated with sorafenib.
Author:	Chen, D\|Zhao, P\|Li, S Q\|Xiao, W K\|Yin, X Y\|Peng, B G\|Liang, L J
PMID:	23845703

137.
Journal:	Biochem Soc Trans. 2013 Aug;41(4):917-22.
Title:	Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression.
Author:	Nemazanyy, Ivan\|Espeillac, Catherine\|Pende, Mario\|Panasyuk, Ganna
PMID:	23863156

138.
Journal:	Biochim Biophys Acta. 2013 Dec;1833(12):2890-2899.
Title:	A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma.
Author:	Wang, Ning\|Feng, Yibin\|Zhu, Meifen\|Siu, Fung-Ming\|Ng, Kwan-Ming\|Che, Chi-Ming
PMID:	23906794

139.
Journal:	J Clin Invest. 2013 Jul;123(7):2832-49.
Title:	Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
Author:	Chen, Chia-Lin\|Tsukamoto, Hidekazu\|Liu, Jian-Chang\|Kashiwabara, Claudine\|Feldman, Douglas\|Sher, Linda\|Dooley, Steven\|French, Samuel W\|Mishra, Lopa\|Petrovic, Lydia\|Jeong, Joseph H\|Machida, Keigo
PMID:	23921128

140.
Journal:	PLoS One. 2013 Jul 29;8(7):e70010.
Title:	Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells.
Author:	Saito, Tomoko\|Chiba, Tetsuhiro\|Yuki, Kaori\|Zen, Yoh\|Oshima, Motohiko\|Koide, Shuhei\|Motoyama, Tenyu\|Ogasawara, Sadahisa\|Suzuki, Eiichiro\|Ooka, Yoshihiko\|Tawada, Akinobu\|Tada, Motohisa\|Kanai, Fumihiko\|Takiguchi, Yuichi\|Iwama, Atsushi\|Yokosuka, Osamu
PMID:	23922888

141.
Journal:	Toxicol Appl Pharmacol. 2013 Nov 1;272(3):568-78.
Title:	Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.
Author:	Hernandez-Breijo, Borja\|Monserrat, Jorge\|Roman, Irene D\|Gonzalez-Rodriguez, Agueda\|Fernandez-Moreno, Ma Dolores\|Lobo, M Val T\|Valverde, Angela M\|Gisbert, Javier P\|Guijarro, Luis G
PMID:	23958494

142.
Journal:	Cancer Lett. 2013 Dec 1;341(2):139-49.
Title:	Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
Author:	Shrimali, Deepti\|Shanmugam, Muthu K\|Kumar, Alan Prem\|Zhang, Jingwen\|Tan, Benny K H\|Ahn, Kwang Seok\|Sethi, Gautam
PMID:	23962559

143.
Journal:	PLoS One. 2013 Sep 19;8(9):e75104.
Title:	SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice.
Author:	Li, Lei\|Wang, Chunmei\|Calvisi, Diego F\|Evert, Matthias\|Pilo, Maria G\|Jiang, Lijie\|Yuneva, Mariia\|Chen, Xin
PMID:	24069385

144.
Journal:	PLoS One. 2013 Nov 6;8(11):e80411.
Title:	Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein.
Author:	Nakano, Masayuki\|Nakashima, Akio\|Nagano, Taiki\|Ishikawa, Shintaro\|Kikkawa, Ushio\|Kamada, Shinji
PMID:	24223226

145.
Journal:	Int J Mol Sci. 2013 Nov 25;14(12):23212-30.
Title:	Blocking autophagic flux enhances matrine-induced apoptosis in human hepatoma cells.
Author:	Wang, Li\|Gao, Chun\|Yao, Shukun\|Xie, Bushan
PMID:	24287900

146.
Journal:	PLoS One. 2013 Nov 27;8(11):e82346.
Title:	Branched chain amino acid suppresses hepatocellular cancer stem cells through the activation of mammalian target of rapamycin.
Author:	Nishitani, Shinobu\|Horie, Mayumi\|Ishizaki, Sonoko\|Yano, Hirohisa
PMID:	24312415

147.
Journal:	PLoS One. 2013 Dec 20;8(12):e82918.
Title:	Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression.
Author:	Marcq, Ingrid\|Nyga, Remy\|Cartier, Flora\|Amrathlal, Rabbind Singh\|Ossart, Christele\|Ouled-Haddou, Hakim\|Ghamlouch, Hussein\|Galmiche, Antoine\|Chatelain, Denis\|Lamotte, Luciane\|Debuysscher, Veronique\|Fuentes, Vincent\|Nguyen-Khac, Eric\|Regimbeau, Jean-Marc\|Ma
PMID:	24376606

148.
Journal:	Liver Cancer. 2013 Aug;2(3-4):345-64.
Title:	Clinical trials in hepatocellular carcinoma: an update.
Author:	Shen, Ying-Chun\|Lin, Zhong-Zhe\|Hsu, Chih-Hung\|Hsu, Chiun\|Shao, Yu-Yun\|Cheng, Ann-Lii
PMID:	24400222

149.
Journal:	Cancer Biol Ther. 2014 Feb;15(2):156-69.
Title:	AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway.
Author:	Sanli, Toran\|Steinberg, Gregory R\|Singh, Gurmit\|Tsakiridis, Theodoros
PMID:	24100703

150.
Journal:	Hepatology. 2014 May;59(5):1886-99.
Title:	EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.
Author:	Pellegrino, Rossella\|Calvisi, Diego F\|Neumann, Olaf\|Kolluru, Venkatesh\|Wesely, Josephine\|Chen, Xin\|Wang, Chunmei\|Wuestefeld, Torsten\|Ladu, Sara\|Elgohary, Nahla\|Bermejo, Justo Lorenzo\|Radlwimmer, Bernhard\|Zornig, Martin\|Zender, Lars\|Dombrowski, Frank\|Evert
PMID:	24285179

151.
Journal:	Int J Oncol. 2014 Feb;44(2):491-504.
Title:	Segregation of signaling proteins as prognostic predictors for local recurrence and distant metastasis in hepatocellular carcinoma.
Author:	Yeh, Chau-Ting\|Huang, Ya-Hui\|Liang, Kung-Hao\|Chang, Ming-Ling\|Hsu, Chao-Wei\|Chen, Yi-Cheng\|Chen, Tse-Ching\|Yeh, Ta-Sen\|Lee, Wei-Chen
PMID:	24297625

152.
Journal:	J Hepatol. 2014 Apr;60(4):855-65.
Title:	Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends.
Author:	Matter, Matthias S\|Decaens, Thomas\|Andersen, Jesper B\|Thorgeirsson, Snorri S
PMID:	24308993

153.
Journal:	Technol Cancer Res Treat. 2014 Aug;13(4):377-85.
Title:	Combination of cetuximab and rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma.
Author:	Geng, J\|Li, X\|Lang, X\|Qiao, C\|Hu, M\|Yang, J\|Feng, J\|Lv, M
PMID:	24325131

154.
Journal:	Curr Med Chem. 2014 Apr;21(10):1231-46.
Title:	FoxO proteins: regulation and molecular targets in liver cancer.
Author:	Carbajo-Pescador, S\|Mauriz, J L\|Garcia-Palomo, A\|Gonzalez-Gallego, J
PMID:	24372208

155.
Journal:	Int J Oncol. 2014 Mar;44(3):769-80.
Title:	Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression.
Author:	Zhang, Hai\|Cheng, Shanyu\|Zhang, Min\|Ma, Xiuping\|Zhang, Li\|Wang, Yipin\|Rong, Rong\|Ma, Juan\|Xia, Shukai\|Du, Mingzhan\|Shi, Feng\|Wang, Jie\|Yang, Qinyi\|Bai, Xiaoming\|Leng, Jing
PMID:	24378923

156.
Journal:	Mol Cancer. 2014 Jan 3;13:2.
Title:	Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin.
Author:	Ou, Da-Liang\|Lee, Bin-Shyun\|Lin, Liang-In\|Liou, Jun-Yang\|Liao, Sheng-Chieh\|Hsu, Chiun\|Cheng, Ann-Lii
PMID:	24387108

157.
Journal:	Autophagy. 2014 Mar;10(3):416-30.
Title:	Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation.
Author:	Liu, Bo\|Fang, Mengdie\|Hu, Ye\|Huang, Baoshan\|Li, Ning\|Chang, Chunmei\|Huang, Rui\|Xu, Xiao\|Yang, Zhenggang\|Chen, Zhi\|Liu, Wei
PMID:	24401568

158.
Journal:	Cancer Res. 2014 Mar 15;74(6):1728-38.
Title:	HDAC2 provides a critical support to malignant progression of hepatocellular carcinoma through feedback control of mTORC1 and AKT.
Author:	Noh, Ji Heon\|Bae, Hyun Jin\|Eun, Jung Woo\|Shen, Qingyu\|Park, Se Jin\|Kim, Hyung Seok\|Nam, Boas\|Shin, Woo Chan\|Lee, Eun Kyung\|Lee, Kyungbun\|Jang, Ja-Jun\|Park, Won Sang\|Lee, Jung Young\|Nam, Suk Woo
PMID:	24448241

159.
Journal:	Cardiovasc Intervent Radiol. 2014 Oct;37(5):1343-51.
Title:	Role for putative hepatocellular carcinoma stem cell subpopulations in biological response to incomplete thermal ablation: in vitro and in vivo pilot study.
Author:	Thompson, Scott M\|Callstrom, Matthew R\|Butters, Kim A\|Sutor, Shari L\|Knudsen, Bruce\|Grande, Joseph P\|Roberts, Lewis R\|Woodrum, David A
PMID:	24452318

160.
Journal:	PLoS One. 2014 Jan 23;9(1):e86371.
Title:	eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1.
Author:	Li, Man\|Wang, Jian\|Yang, Lei\|Gao, Ping\|Tian, Qing-Bao\|Liu, Dian-Wu
PMID:	24466059

161.
Journal:	Oncol Rep. 2014 May;31(5):2099-106.
Title:	Prostaglandin E(2) receptor EP2 mediates Snail expression in hepatocellular carcinoma cells.
Author:	Cheng, Shan-Yu\|Zhang, Hai\|Zhang, Min\|Xia, Shu-Kai\|Bai, Xiao-Ming\|Zhang, Li\|Ma, Juan\|Rong, Rong\|Wang, Yi-Pin\|Du, Ming-Zhan\|Wang, Jie\|Chen, Meng\|Shi, Feng\|Yang, Qin-Yi\|Leng, Jing
PMID:	24626807

162.
Journal:	Pediatr Transplant. 2014 Jun;18(4):E114-9.
Title:	Angiosarcoma successfully treated with liver transplantation and sirolimus.
Author:	Xue, Megan\|Masand, Prakash\|Thompson, Patrick\|Finegold, Milton\|Leung, Daniel H
PMID:	24641525

163.
Journal:	Mol Cancer Ther. 2014 Jun;13(6):1589-98.
Title:	Inhibition of Akt reverses the acquired resistance to sorafenib by switching protective autophagy to autophagic cell death in hepatocellular carcinoma.
Author:	Zhai, Bo\|Hu, Fengli\|Jiang, Xian\|Xu, Jun\|Zhao, Dali\|Liu, Bing\|Pan, Shangha\|Dong, Xuesong\|Tan, Gang\|Wei, Zheng\|Qiao, Haiquan\|Jiang, Hongchi\|Sun, Xueying
PMID:	24705351

164.
Journal:	Biomed Res Int. 2014;2014:789591.
Title:	A proteomic view to characterize the effect of chitosan nanoparticle to hepatic cells: is chitosan nanoparticle an enhancer of PI3K/AKT1/mTOR pathway?
Author:	Yang, Ming-Hui\|Yuan, Shyng-Shiou\|Huang, Ying-Fong\|Lin, Po-Chiao\|Lu, Chi-Yu\|Chung, Tze-Wen\|Tyan, Yu-Chang
PMID:	24757677

165.
Journal:	Hum Pathol. 2014 Jun;45(6):1294-301.
Title:	Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis.
Author:	Wu, Han-Chieh\|Tsai, Hung-Wen\|Teng, Chiao-Fang\|Hsieh, Wen-Chuan\|Lin, Yih-Jyh\|Wang, Lily Hui-Ching\|Yuan, Quan\|Su, Ih-Jen
PMID:	24767856

166.
Journal:	Biochimie. 2014 Aug;103:118-25.
Title:	CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition.
Author:	Wang, Feng-Ze\|Chang, Zheng-Yao\|Fei, Hong-Rong\|Yang, Ming-Feng\|Yang, Xiao-Yi\|Sun, Bao-Liang
PMID:	24793486

167.
Journal:	World J Hepatol. 2014 Apr 27;6(4):230-42.
Title:	Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions.
Author:	Bennukul, Kangsadarn\|Numkliang, Sucha\|Leardkamolkarn, Vijittra
PMID:	24799992

168.
Journal:	Cancer Biol Ther. 2014 Aug;15(8):992-9.
Title:	Rapamycin enhances cetuximab cytotoxicity by inhibiting mTOR-mediated drug resistance in mesenchymal hepatoma cells.
Author:	Chen, Wei\|Hu, Qi-Da\|Xia, Xue-Feng\|Liang, Chao\|Liu, Hao\|Zhang, Qi\|Ma, Tao\|Liang, Feng\|Liang, Ting-Bo
PMID:	24800850

169.
Journal:	Exp Eye Res. 2014 Jul;124:67-73.
Title:	The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.
Author:	Brodowska, Katarzyna\|Al-Moujahed, Ahmad\|Marmalidou, Anna\|Meyer Zu Horste, Melissa\|Cichy, Joanna\|Miller, Joan W\|Gragoudas, Evangelos\|Vavvas, Demetrios G
PMID:	24837142

170.
Journal:	Cancer Res. 2014 Aug 15;74(16):4515-25.
Title:	beta-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastoma.
Author:	Mokkapati, Sharada\|Niopek, Katharina\|Huang, Le\|Cunniff, Kegan J\|Ruteshouser, E Cristy\|deCaestecker, Mark\|Finegold, Milton J\|Huff, Vicki
PMID:	24848510

171.
Journal:	Cell Death Dis. 2014 May 22;5:e1244.
Title:	Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma.
Author:	Chen, K-D\|Wang, C-C\|Tsai, M-C\|Wu, C-H\|Yang, H-J\|Chen, L-Y\|Nakano, T\|Goto, S\|Huang, K-T\|Hu, T-H\|Chen, C-L\|Lin, C-C
PMID:	24853422

172.
Journal:	Oncol Rep. 2014 Jul;32(1):235-42.
Title:	Celastrol inhibits the HIF-1alpha pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells.
Author:	Ma, Juan\|Han, Li Zhuo\|Liang, He\|Mi, Chunliu\|Shi, Hui\|Lee, Jung Joon\|Jin, Xuejun
PMID:	24859482

173.
Journal:	Oncotarget. 2014 May 30;5(10):3012-22.
Title:	Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing.
Author:	Janku, Filip\|Kaseb, Ahmed O\|Tsimberidou, Apostolia M\|Wolff, Robert A\|Kurzrock, Razelle
PMID:	24931142

174.
Journal:	Toxicol Lett. 2014 Aug 17;229(1):265-72.
Title:	Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway.
Author:	An, Jing\|Wang, Xiu\|Guo, Panpan\|Zhong, Yufang\|Zhang, Xinyu\|Yu, Zhiqiang
PMID:	24960055

175.
Journal:	Oncotarget. 2014 Jul 15;5(13):5113-24.
Title:	FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2.
Author:	Liu, Li-Li\|Lu, Shi-Xun\|Li, Min\|Li, Lin-Zi\|Fu, Jia\|Hu, Wen\|Yang, Yuan-Zhong\|Luo, Rong-Zhen\|Zhang, Chris Zhiyi\|Yun, Jing-Ping
PMID:	24970808

176.
Journal:	Oncotarget. 2014 Jun 15;5(11):3662-72.
Title:	Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma.
Author:	Liu, Wei-Lin\|Gao, Ming\|Tzen, Kai-Yuan\|Tsai, Chiao-Ling\|Hsu, Feng-Ming\|Cheng, Ann-Lii\|Cheng, Jason Chia-Hsien
PMID:	25004403

177.
Journal:	Gene. 2014 Sep 10;548(1):91-100.
Title:	The RNA expression signature of the HepG2 cell line as determined by the integrated analysis of miRNA and mRNA expression profiles.
Author:	Bai, Yunfei\|Xue, Ying\|Xie, Xueying\|Yu, Tong\|Zhu, Yihua\|Ge, Qinyu\|Lu, Zuhong
PMID:	25014136

178.
Journal:	Oncotarget. 2014 Aug 15;5(15):6218-28.
Title:	MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R.
Author:	Ge, Yi-Yuan\|Shi, Qing\|Zheng, Zhi-Yuan\|Gong, Jiao\|Zeng, Chunxian\|Yang, Jine\|Zhuang, Shi-Mei
PMID:	25026290

179.
Journal:	Oncotarget. 2014 Jul 30;5(14):5819-31.
Title:	Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts.
Author:	Wei, Wei\|Wu, Song\|Wang, Xiaolin\|Sun, Chris Kin-Wai\|Yang, Xiaoyang\|Yan, Xinrui\|Chua, Mei-Sze\|So, Samuel
PMID:	25051375

180.
Journal:	Asian Pac J Trop Med. 2014 May;7(5):368-72.
Title:	Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer.
Author:	Pu, Xia\|Guo, Qing-Xi\|Long, Han-An\|Yang, Cheng-Wan
PMID:	25063062

181.
Journal:	Br J Cancer. 2014 Sep 9;111(6):1159-67.
Title:	Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts.
Author:	Chiu, M\|Tardito, S\|Pillozzi, S\|Arcangeli, A\|Armento, A\|Uggeri, J\|Missale, G\|Bianchi, M G\|Barilli, A\|Dall'Asta, V\|Campanini, N\|Silini, E M\|Fuchs, J\|Armeanu-Ebinger, S\|Bussolati, O
PMID:	25072259

182.
Journal:	Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11592-9.
Title:	Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.
Author:	Cornu, Marion\|Oppliger, Wolfgang\|Albert, Verena\|Robitaille, Aaron M\|Trapani, Francesca\|Quagliata, Luca\|Fuhrer, Tobias\|Sauer, Uwe\|Terracciano, Luigi\|Hall, Michael N
PMID:	25082895

183.
Journal:	Oncol Rep. 2014 Oct;32(4):1689-94.
Title:	CIP2A regulates cell proliferation via the AKT signaling pathway in human lung cancer.
Author:	Lei, Ningjing\|Peng, Bo\|Zhang, Jian-Ying
PMID:	25109354

184.
Journal:	Nanotechnology. 2014 Sep 12;25(36):365101.
Title:	Cationic poly(amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular carcinoma cells.
Author:	Li, Yubin\|Wang, Shaofei\|Wang, Ziyu\|Qian, Xiaolu\|Fan, Jiajun\|Zeng, Xian\|Sun, Yun\|Song, Ping\|Feng, Meiqing\|Ju, Dianwen
PMID:	25140534

185.
Journal:	Mar Drugs. 2014 Sep 12;12(9):4783-98.
Title:	11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.
Author:	Lin, Jen-Jie\|Su, Jui-Hsin\|Tsai, Chi-Chu\|Chen, Yi-Jen\|Liao, Ming-Hui\|Wu, Yu-Jen
PMID:	25222667

186.
Journal:	PLoS One. 2014 Sep 17;9(9):e107149.
Title:	Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression.
Author:	Nair, Sandhya V G\|Ziaullah\|Rupasinghe, H P Vasantha
PMID:	25229655

187.
Journal:	Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):831-42.
Title:	Integration of genomic information in the clinical management of HCC.
Author:	Quetglas, Iris M\|Moeini, Agrin\|Pinyol, Roser\|Llovet, Josep M
PMID:	25260311

188.
Journal:	Drug Discov Ther. 2014 Aug;8(4):154-64.
Title:	Advances in the study of molecularly targeted agents to treat hepatocellular carcinoma.
Author:	Chen, Jialu\|Gao, Jianjun
PMID:	25262594

189.
Journal:	J Biomed Sci. 2014 Oct 15;21:98.
Title:	The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis.
Author:	Su, Ih-Jen\|Wang, Lily Hui-Ching\|Hsieh, Wen-Chuan\|Wu, Han-Chieh\|Teng, Chiao-Fang\|Tsai, Hung-Wen\|Huang, Wenya
PMID:	25316153

190.
Journal:	Sci Rep. 2014 Oct 20;4:6683.
Title:	Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib.
Author:	Pan, Hongming\|Wang, Zhanggui\|Jiang, Liming\|Sui, Xinbing\|You, Liangkun\|Shou, Jiawei\|Jing, Zhao\|Xie, Jiansheng\|Ge, Weiting\|Cai, Xiujun\|Huang, Wendong\|Han, Weidong
PMID:	25327881

191.
Journal:	Nat Genet. 2014 Dec;46(12):1267-73.
Title:	Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.
Author:	Totoki, Yasushi\|Tatsuno, Kenji\|Covington, Kyle R\|Ueda, Hiroki\|Creighton, Chad J\|Kato, Mamoru\|Tsuji, Shingo\|Donehower, Lawrence A\|Slagle, Betty L\|Nakamura, Hiromi\|Yamamoto, Shogo\|Shinbrot, Eve\|Hama, Natsuko\|Lehmkuhl, Megan\|Hosoda, Fumie\|Arai, Yasuhito\|Walk
PMID:	25362482

192.
Journal:	Semin Liver Dis. 2014 Nov;34(4):363-75.
Title:	Molecular profiling of liver tumors: classification and clinical translation for decision making.
Author:	Pinyol, Roser\|Nault, Jean Charles\|Quetglas, Iris M\|Zucman-Rossi, Jessica\|Llovet, Josep M
PMID:	25369299

193.
Journal:	Pathologe. 2014 Nov;35 Suppl 2:177-84.
Title:	[EEF1A2 inhibits the p53 function in hepatocellular carcinoma via PI3K/AKT/mTOR-dependent stabilization of MDM4].
Author:	Longerich, T
PMID:	25394965

194.
Journal:	Mol Cancer. 2014 Nov 26;13:253.
Title:	Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma via targeting AKT-mTOR pathway.
Author:	Zhang, Yanqiong\|Guo, Xiaodong\|Xiong, Lu\|Yu, Lingxiang\|Li, Zhiwei\|Guo, Qiuyan\|Li, Zhiyan\|Li, Boan\|Lin, Na
PMID:	25424347

195.
Journal:	World J Hepatol. 2014 Nov 27;6(11):776-82.
Title:	Mammalian target of rapamycin inhibition in hepatocellular carcinoma.
Author:	Ashworth, Rene E\|Wu, Jennifer
PMID:	25429315

196.
Journal:	PLoS One. 2014 Dec 8;9(12):e113479.
Title:	U12, a UDCA derivative, acts as an anti-hepatoma drug lead and inhibits the mTOR/S6K1 and cyclin/CDK complex pathways.
Author:	Xu, Yang\|Luo, Qiang\|Lin, Ting\|Zeng, Zhiping\|Wang, Guanghui\|Zeng, Dequan\|Ding, Rong\|Sun, Cuiling\|Zhang, Xiao-Kun\|Chen, Haifeng
PMID:	25486097

197.
Journal:	J Hepatol. 2015 Jan;62(1):131-9.
Title:	Increased autophagy sustains the survival and pro-tumourigenic effects of neutrophils in human hepatocellular carcinoma.
Author:	Li, Xue-Feng\|Chen, Dong-Ping\|Ouyang, Fang-Zhu\|Chen, Min-Min\|Wu, Yan\|Kuang, Dong-Ming\|Zheng, Limin
PMID:	25152203

198.
Journal:	J Appl Toxicol. 2015 May;35(5):485-92.
Title:	Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells.
Author:	Gao, Qilong\|Liu, Huaimin\|Yao, Yamin\|Geng, Liang\|Zhang, Xinfeng\|Jiang, Lifeng\|Shi, Bian\|Yang, Feng
PMID:	25178877

199.
Journal:	Mol Carcinog. 2015 Dec;54(12):1554-66.
Title:	The collagen triple helix repeat containing 1 facilitates hepatitis B virus-associated hepatocellular carcinoma progression by regulating multiple cellular factors and signal cascades.
Author:	Zhang, Rui\|Cao, Yanhua\|Bai, Lan\|Zhu, Chengliang\|Li, Rui\|He, Hui\|Liu, Yingle\|Wu, Kailang\|Liu, Fang\|Wu, Jianguo
PMID:	25263696

200.
Journal:	Dig Dis Sci. 2015 Apr;60(4):919-28.
Title:	Influence of Rictor and Raptor Expression of mTOR Signaling on Long-Term Outcomes of Patients with Hepatocellular Carcinoma.
Author:	Kaibori, Masaki\|Shikata, Nobuaki\|Sakaguchi, Tatsuma\|Ishizaki, Morihiko\|Matsui, Kosuke\|Iida, Hiroya\|Tanaka, Yoshito\|Miki, Hirokazu\|Nakatake, Richi\|Okumura, Tadayoshi\|Tokuhara, Katsuji\|Inoue, Kentaro\|Wada, Jouji\|Oda, Michio\|Nishizawa, Mikio\|Kon, Masanori
PMID:	25371154

201.
Journal:	Tumour Biol. 2015 Apr;36(4):2323-34.
Title:	Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation.
Author:	Zhai, Bo\|Jiang, Xian\|He, Changjun\|Zhao, Dali\|Ma, Lixin\|Xu, Lishan\|Jiang, Hongchi\|Sun, Xueying
PMID:	25416439

202.
Journal:	Am J Pathol. 2015 Feb;185(2):399-408.
Title:	mTOR and PDGF pathway blockade inhibits liver metastasis of colorectal cancer by modulating the tumor microenvironment.
Author:	Yuge, Ryo\|Kitadai, Yasuhiko\|Shinagawa, Kei\|Onoyama, Mieko\|Tanaka, Shinji\|Yasui, Wataru\|Chayama, Kazuaki
PMID:	25478811

203.
Journal:	J Agric Food Chem. 2015 Jan 14;63(1):208-15.
Title:	4-Acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production.
Author:	Chang, Chien-Hsin\|Huang, Tur-Fu\|Lin, Kung-Tin\|Hsu, Chun-Chieh\|Chang, Wei-Luen\|Wang, Shih-Wei\|Ko, Feng-Nien\|Peng, Hui-Chin\|Chung, Ching-Hu
PMID:	25494404

204.
Journal:	Cancer Lett. 2015 Feb 28;357(2):510-9.
Title:	RNA over-editing of BLCAP contributes to hepatocarcinogenesis identified by whole-genome and transcriptome sequencing.
Author:	Hu, Xueda\|Wan, Shengqing\|Ou, Ying\|Zhou, Boping\|Zhu, Jialou\|Yi, Xin\|Guan, Yanfang\|Jia, Wenlong\|Liu, Xing\|Wang, Qiudao\|Qi, Yao\|Yuan, Qing\|Huang, Wanqiu\|Liao, Weijia\|Wang, Yun\|Zhang, Qinghua\|Xiao, Huasheng\|Chen, Xinchun\|Huang, Jian
PMID:	25499081

205.
Journal:	Mol Med. 2015 Mar 24;20:684-96.
Title:	Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.
Author:	Li, Chung-Hsien\|Lin, Ming-Hong\|Chu, Shih-Han\|Tu, Pang-Hsien\|Fang, Cheng-Chieh\|Yen, Chia-Hung\|Liang, Peir-In\|Huang, Jason C\|Su, Yu-Chia\|Sytwu, Huey-Kang\|Chen, Yi-Ming Arthur
PMID:	25535034

206.
Journal:	Oncotarget. 2015 Feb 10;6(4):2222-34.
Title:	SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice.
Author:	Delogu, Salvatore\|Wang, Chunmei\|Cigliano, Antonio\|Utpatel, Kirsten\|Sini, Marcella\|Longerich, Thomas\|Waldburger, Nina\|Breuhahn, Kai\|Jiang, Lijie\|Ribback, Silvia\|Dombrowski, Frank\|Evert, Matthias\|Chen, Xin\|Calvisi, Diego F
PMID:	25537506

207.
Journal:	Eur J Pharmacol. 2015 Feb 15;749:81-8.
Title:	Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells.
Author:	Li, Ting\|Tang, Zheng-Hai\|Xu, Wen-Shan\|Wu, Guo-Sheng\|Wang, Ya-Fang\|Chang, Lin-Lin\|Zhu, Hong\|Chen, Xiu-Ping\|Wang, Yi-Tao\|Chen, Yi\|Lu, Jin-Jian
PMID:	25592318

208.
Journal:	Tumour Biol. 2015 Jun;36(6):4453-9.
Title:	MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3.
Author:	Cao, Gang\|Dong, Weihua\|Meng, Xiaoxi\|Liu, Hongchao\|Liao, Huaqiang\|Liu, Shiyuan
PMID:	25608840

209.
Journal:	J Hepatol. 2015 Jun;62(6):1296-303.
Title:	Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis.
Author:	Piguet, Anne-Christine\|Saran, Uttara\|Simillion, Cedric\|Keller, Irene\|Terracciano, Luigi\|Reeves, Helen L\|Dufour, Jean-Francois
PMID:	25623824

210.
Journal:	Am J Cancer Res. 2014 Dec 15;5(1):125-39. eCollection 2015.
Title:	Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma.
Author:	Liao, Hui\|Huang, Yu\|Guo, Botang\|Liang, Bo\|Liu, Xincheng\|Ou, Huohui\|Jiang, Chenglong\|Li, Xianghong\|Yang, Dinghua
PMID:	25628925

211.
Journal:	Discov Med. 2015 Jan;19(102):7-14.
Title:	Novel molecular targets for diagnosis and treatment of hepatocellular carcinoma.
Author:	Ma, Lifang\|Ji, Lijuan\|Yu, Yongchun\|Wang, Jiayi
PMID:	25636956

212.
Journal:	Mol Cancer. 2015 Feb 3;14:18.
Title:	Oncogenic KRAS promotes malignant brain tumors in zebrafish.
Author:	Ju, Bensheng\|Chen, Wenbiao\|Orr, Brent A\|Spitsbergen, Jan M\|Jia, Sujuan\|Eden, Christopher J\|Henson, Hannah E\|Taylor, Michael R
PMID:	25644510

213.
Journal:	Cancer Res. 2015 Apr 1;75(7):1470-81.
Title:	CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling.
Author:	Jiang, Feng\|Chen, Lei\|Yang, Ying-Cheng\|Wang, Xian-Ming\|Wang, Ruo-Yu\|Li, Liang\|Wen, Wen\|Chang, Yan-Xin\|Chen, Cai-Yang\|Tang, Jing\|Liu, Gao-Mi-Yang\|Huang, Wen-Tao\|Xu, Lin\|Wang, Hong-Yang
PMID:	25649767

214.
Journal:	Biochem Biophys Res Commun. 2015 Mar 6;458(2):334-40.
Title:	FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells.
Author:	Schuster, Susanne\|Penke, Melanie\|Gorski, Theresa\|Gebhardt, Rolf\|Weiss, Thomas S\|Kiess, Wieland\|Garten, Antje
PMID:	25656579

215.
Journal:	J Cell Physiol. 2015 Sep;230(9):2281-98.
Title:	Nexavar/Stivarga and viagra interact to kill tumor cells.
Author:	Tavallai, Mehrad\|Hamed, Hossein A\|Roberts, Jane L\|Cruickshanks, Nichola\|Chuckalovcak, John\|Poklepovic, Andrew\|Booth, Laurence\|Dent, Paul
PMID:	25704960

216.
Journal:	Mol Cancer Ther. 2015 May;14(5):1224-35.
Title:	Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus.
Author:	Huynh, Hung\|Hao, Huai-Xiang\|Chan, Stephen L\|Chen, David\|Ong, Richard\|Soo, Khee Chee\|Pochanard, Panisa\|Yang, David\|Ruddy, David\|Liu, Manway\|Derti, Adnan\|Balak, Marissa N\|Palmer, Michael R\|Wang, Yan\|Lee, Benjamin H\|Sellami, Dalila\|Zhu, Andrew X\|Schlegel, Ro
PMID:	25724664

217.
Journal:	Oncogene. 2015 Dec 3;34(49):6007-17.
Title:	Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1alpha to promote the metastasis of hepatocellular carcinoma.
Author:	Hu, F\|Deng, X\|Yang, X\|Jin, H\|Gu, D\|Lv, X\|Wang, C\|Zhang, Y\|Huo, X\|Shen, Q\|Luo, Q\|Zhao, F\|Ge, T\|Zhao, F\|Chu, W\|Shu, H\|Yao, M\|Fan, J\|Qin, W
PMID:	25745995

218.
Journal:	Int J Oncol. 2015 May;46(5):2216-22.
Title:	Effects of fucoidan on proliferation, AMP-activated protein kinase, and downstream metabolism- and cell cycle-associated molecules in poorly differentiated human hepatoma HLF cells.
Author:	Kawaguchi, Takumi\|Hayakawa, Masako\|Koga, Hironori\|Torimura, Takuji
PMID:	25776104

219.
Journal:	J BUON. 2015 Jan-Feb;20(1):218-22.
Title:	Sorafenib inhibits liver cancer growth by decreasing mTOR, AKT, and PI3K expression.
Author:	Zhang, Chi-zhi\|Wang, Xiao-dong\|Wang, Hong-wei\|Cai, Yue\|Chao, Li-qin
PMID:	25778319

220.
Journal:	PLoS One. 2015 Mar 19;10(3):e0119888.
Title:	Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression.
Author:	Narsale, Aditi A\|Enos, Reilly T\|Puppa, Melissa J\|Chatterjee, Saurabh\|Murphy, E Angela\|Fayad, Raja\|Pena, Majorette O'\|Durstine, J Larry\|Carson, James A
PMID:	25789991

221.
Journal:	Oncoscience. 2015 Jan 6;2(1):59-70. eCollection 2015.
Title:	Alpha-fetoprotein activates AKT/mTOR signaling to promote CXCR4 expression and migration of hepatoma cells.
Author:	Zhu, Mingyue\|Guo, Junli\|Xia, Hua\|Li, Wei\|Lu, Yan\|Dong, Xu\|Chen, Yi\|Xie, Xieju\|Fu, Shigan\|Li, Mengsen
PMID:	25815363

222.
Journal:	Life Sci. 2015 Jun 15;131:23-9.
Title:	AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells.
Author:	Lv, Qiong\|Zhen, Qianna\|Liu, Lulu\|Gao, Rufei\|Yang, Shumin\|Zhou, Huang\|Goswami, Richa\|Li, Qifu
PMID:	25817233

223.
Journal:	PLoS One. 2015 Mar 30;10(3):e0119512.
Title:	Telomerase inhibition decreases alpha-fetoprotein expression and secretion by hepatocellular carcinoma cell lines: in vitro and in vivo study.
Author:	Tahtouh, Roula\|Azzi, Anne-Sophie\|Alaaeddine, Nada\|Chamat, Soulaima\|Bouharoun-Tayoun, Hasnaa\|Wardi, Layal\|Raad, Issam\|Sarkis, Riad\|Antoun, Najibe Abou\|Hilal, George
PMID:	25822740

224.
Journal:	Biochem Biophys Res Commun. 2015 May 15;460(4):1047-52.
Title:	DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells.
Author:	Obara, Akio\|Fujita, Yoshihito\|Abudukadier, Abulizi\|Fukushima, Toru\|Oguri, Yasuo\|Ogura, Masahito\|Harashima, Shin-Ichi\|Hosokawa, Masaya\|Inagaki, Nobuya
PMID:	25843797

225.
Journal:	Mol Cell Proteomics. 2015 Jun;14(6):1527-45.
Title:	Integrated Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Quantitative Proteomic Analysis Identifies Galectin-1 as a Potential Biomarker for Predicting Sorafenib Resistance i
Author:	Yeh, Chao-Chi\|Hsu, Chih-Hung\|Shao, Yu-Yun\|Ho, Wen-Ching\|Tsai, Mong-Hsun\|Feng, Wen-Chi\|Chow, Lu-Ping
PMID:	25850433

226.
Journal:	J Hepatol. 2015 Sep;63(3):651-60.
Title:	PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients.
Author:	Han, Tao\|Xiang, Dai-Min\|Sun, Wen\|Liu, Na\|Sun, Huan-Lin\|Wen, Wen\|Shen, Wei-Feng\|Wang, Ruo-Yu\|Chen, Cheng\|Wang, Xue\|Cheng, Zhuo\|Li, Heng-Yu\|Wu, Meng-Chao\|Cong, Wen-Ming\|Feng, Gen-Sheng\|Ding, Jin\|Wang, Hong-Yang
PMID:	25865556

227.
Journal:	J Biochem Mol Toxicol. 2015 Oct;29(10):458-464.
Title:	Arctigenin, a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3-K/Akt Signaling.
Author:	Jiang, Xiaoxin\|Zeng, Leping\|Huang, Jufang\|Zhou, Hui\|Liu, Yubin
PMID:	25920004

228.
Journal:	Nutr Cancer. 2015;67(5):748-60.
Title:	Tetrahydro Iso-Alpha Acids and Hexahydro Iso-Alpha Acids from Hops Inhibit Proliferation of Human Hepatocarcinoma Cell Lines and Reduce Diethylnitrosamine Induced Liver Tumor Formation in Rats.
Author:	Starkel, Peter\|De Saeger, Christine\|Delire, Benedicte\|Magat, Julie\|Jordan, Benedicte\|Konda, Veera R\|Tripp, Mathew L\|Borbath, Ivan
PMID:	25941903

229.
Journal:	BMC Cancer. 2015 May 12;15:395.
Title:	Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response.
Author:	Yeo, Winnie\|Chan, Stephen L\|Mo, Frankie K F\|Chu, Cheuk M\|Hui, Joyce W Y\|Tong, Joanne H M\|Chan, Anthony W H\|Koh, Jane\|Hui, Edwin P\|Loong, Herbert\|Lee, Kirsty\|Li, Leung\|Ma, Brigette\|To, Ka F\|Yu, Simon C H
PMID:	25962426

230.
Journal:	Fitoterapia. 2015 Jul;104:31-40.
Title:	SC-III3, a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria.
Author:	Zhao, Peng\|Dou, Yannong\|Chen, Li\|Li, Linhu\|Wei, Zhifeng\|Yu, Juntao\|Wu, Xin\|Dai, Yue\|Xia, Yufeng
PMID:	25964188

231.
Journal:	Oncotarget. 2015 Aug 7;6(22):19055-69.
Title:	Galpha12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4alpha inactivation, which causes c-Met induction.
Author:	Yang, Yoon Mee\|Lee, Chan Gyu\|Koo, Ja Hyun\|Kim, Tae Hyun\|Lee, Jung Min\|An, Jihyun\|Kim, Kang Mo\|Kim, Sang Geon
PMID:	25965999

232.
Journal:	Gastroenterology. 2015 Sep;149(3):741-52.e14.
Title:	mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice.
Author:	Chen, Xinxin\|Wang, Yanan\|Tao, Jun\|Shi, Yuzhuo\|Gai, Xiaochen\|Huang, Fuqiang\|Ma, Qian\|Zhou, Zhenzhen\|Chen, Hongyu\|Zhang, Haihong\|Liu, Zhibo\|Sun, Qian\|Peng, Haiyong\|Chen, Rongrong\|Jing, Yanling\|Yang, Huayu\|Mao, Yilei\|Zhang, Hongbing
PMID:	25980751

233.
Journal:	Oncotarget. 2015 Jul 10;6(19):17147-60.
Title:	The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells.
Author:	Simioni, Carolina\|Cani, Alice\|Martelli, Alberto M\|Zauli, Giorgio\|Alameen, Ayman A M\|Ultimo, Simona\|Tabellini, Giovanna\|McCubrey, James A\|Capitani, Silvano\|Neri, Luca M
PMID:	26003166

234.
Journal:	Cell Biol Int. 2015 Nov;39(11):1217-24.
Title:	Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines.
Author:	Ma, Wanli\|Zhang, Yaqing\|Mu, Hongmei\|Qing, Xiaoming\|Li, Shulian\|Cui, Xiukun\|Lou, Qiang\|Ma, Yuanfang\|Pu, Hongmin\|Hu, Yanzhong
PMID:	26010766

235.
Journal:	Mol Cancer Ther. 2015 Aug;14(8):1805-15.
Title:	Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells.
Author:	Chen, Bryan Wei\|Chen, Wei\|Liang, Hui\|Liu, Hao\|Liang, Chao\|Zhi, Xiao\|Hu, Li-Qiang\|Yu, Xia-Zhen\|Wei, Tao\|Ma, Tao\|Xue, Fei\|Zheng, Lei\|Zhao, Bin\|Feng, Xin-Hua\|Bai, Xue-Li\|Liang, Ting-Bo
PMID:	26026051

236.
Journal:	PLoS One. 2015 Jun 1;10(6):e0127299.
Title:	GC-MS Based Plasma Metabolomics for Identification of Candidate Biomarkers for Hepatocellular Carcinoma in Egyptian Cohort.
Author:	Nezami Ranjbar, Mohammad R\|Luo, Yue\|Di Poto, Cristina\|Varghese, Rency S\|Ferrarini, Alessia\|Zhang, Chi\|Sarhan, Naglaa I\|Soliman, Hanan\|Tadesse, Mahlet G\|Ziada, Dina H\|Roy, Rabindra\|Ressom, Habtom W
PMID:	26030804

237.
Journal:	Dig Dis Sci. 2015 Oct;60(10):3011-8.
Title:	Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
Author:	Wang, Xin\|Han, Longzhi\|Zhang, Jianjun\|Xia, Qiang
PMID:	26055238

238.
Journal:	Oncotarget. 2015 Sep 8;6(26):22880-9.
Title:	Co-expression of CXCL8 and HIF-1alpha is associated with metastasis and poor prognosis in hepatocellular carcinoma.
Author:	Li, Xian-Peng\|Yang, Xiao-Yu\|Biskup, Ewelina\|Zhou, Jiang\|Li, Hong-Liang\|Wu, Yi-Feng\|Chen, Ming-Liang\|Xu, Feng
PMID:	26078356

239.
Journal:	Oncol Rep. 2015 Sep;34(3):1620-8.
Title:	Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs.
Author:	Hsu, Chia-Chi\|Wu, Ling-Chia\|Hsia, Cheng-Yuan\|Yin, Pen-Hui\|Chi, Chin-Wen\|Yeh, Tien-Shun\|Lee, Hsin-Chen
PMID:	26133123

240.
Journal:	Biol Pharm Bull. 2015;38(7):986-91.
Title:	Molecular Targeted Therapy for Hepatocellular Carcinoma: Present Status and Future Directions.
Author:	Choi, Kyung-Ju\|Baik, In Hye\|Ye, Sang-Kyu\|Lee, Yun-Han
PMID:	26133708

241.
Journal:	Exp Ther Med. 2015 May;9(5):1791-1796.
Title:	Antiproliferative effect of the methanol extract from the roots of Petasites japonicus on Hep3B hepatocellular carcinoma cells in vitro and in vivo.
Author:	Kim, Hyun Jung\|Park, Song Yi\|Lee, Hye Min\|Seo, Dong Ik\|Kim, Young-Min
PMID:	26136894

242.
Journal:	Mol Oncol. 2015 Oct;9(8):1501-9.
Title:	Hepatocellular carcinoma: Where there is unmet need.
Author:	Bupathi, Manojkumar\|Kaseb, Ahmed\|Meric-Bernstam, Funda\|Naing, Aung
PMID:	26160430

243.
Journal:	Oncotarget. 2015 Sep 29;6(29):28453-62.
Title:	Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials.
Author:	Subbiah, Ishwaria M\|Falchook, Gerald S\|Kaseb, Ahmed O\|Hess, Kenneth R\|Tsimberidou, Apostolia M\|Fu, Siqing\|Subbiah, Vivek\|Hong, David S\|Naing, Aung\|Piha-Paul, Sarina A\|Akmal, Owais\|Janku, Filip\|Kurzrock, Razelle
PMID:	26164085

244.
Journal:	Mol Med Rep. 2015 Oct;12(4):5077-85.
Title:	Effects of Ras homolog gene family, member C gene silencing combined with rapamycin on hepatocellular carcinoma cell growth.
Author:	Xie, Shu-Li\|Zhu, Ming-Guang\|Chen, Guo-Fu\|Wang, Guang-Yi\|Lv, Guo-Yue
PMID:	26165487

245.
Journal:	Biochem Biophys Res Commun. 2015 Sep 18;465(2):167-73.
Title:	Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.
Author:	Nayeb-Hashemi, Hamed\|Desai, Anal\|Demchev, Valeriy\|Bronson, Roderick T\|Hornick, Jason L\|Cohen, David E\|Ukomadu, Chinweike
PMID:	26225745

246.
Journal:	Oncol Rep. 2015 Oct;34(4):1708-16.
Title:	The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth.
Author:	Wang, Congren\|Wang, Xuejin\|Su, Zijian\|Fei, Hongjiang\|Liu, Xiaoyu\|Pan, Qunxiong
PMID:	26239364

247.
Journal:	Int J Oncol. 2015 Oct;47(4):1585-93.
Title:	MiR-132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3.
Author:	Liu, Kai\|Li, Xingliang\|Cao, Yuchen\|Ge, Yuanyuan\|Wang, Jianmeng\|Shi, Bo
PMID:	26252738

248.
Journal:	Oncotarget. 2015 Sep 15;6(27):24448-62.
Title:	miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR.
Author:	Li, Wenhua\|Chang, Jinjia\|Wang, Shanshan\|Liu, Xinyang\|Peng, Junjie\|Huang, Dan\|Sun, Menghong\|Chen, Zhiyu\|Zhang, Wen\|Guo, Weijian\|Li, Jin
PMID:	26259252

249.
Journal:	Biochem Biophys Res Commun. 2015 Sep 25;465(3):494-500.
Title:	Autophagy inhibition sensitizes KU-0063794-mediated anti-HepG2 hepatocellular carcinoma cell activity in vitro and in vivo.
Author:	Yongxi, Tong\|Haijun, Huang\|Jiaping, Zheng\|Guoliang, Shao\|Hongying, Pan
PMID:	26278819

250.
Journal:	J Hepatol. 2015 Dec;63(6):1378-89.
Title:	CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARalpha pathways.
Author:	Li, Jibin\|Huang, Qichao\|Long, Xiaoyu\|Zhang, Jing\|Huang, Xiaojun\|Aa, Jiye\|Yang, Hushan\|Chen, Zhinan\|Xing, Jinliang
PMID:	26282231

251.
Journal:	Hum Pathol. 2015 Jul;46(7):1068-77.
Title:	ARID2, p110alpha, p53, and beta-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications.
Author:	You, Jason\|Yang, Hushan\|Lai, Yinzhi\|Simon, Lindsay\|Au, Jen\|Burkart, Ashlie L
PMID:	26284269

252.
Journal:	BMC Gastroenterol. 2015 Sep 14;15:118.
Title:	Epithelial to mesenchymal transition in the liver field: the double face of Everolimus in vitro.
Author:	Masola, Valentina\|Carraro, Amedeo\|Zaza, Gianluigi\|Bellin, Gloria\|Montin, Umberto\|Violi, Paola\|Lupo, Antonio\|Tedeschi, Umberto
PMID:	26369804

253.
Journal:	Am J Cancer Res. 2015 Jul 15;5(8):2376-86. eCollection 2015.
Title:	A preclinical study on the combination therapy of everolimus and transarterial chemoembolization in hepatocellular carcinoma.
Author:	Chow, Ariel Km\|Yau, Thomas Cc\|Ng, Lui\|Chu, Andrew Cy\|Law, Wai-Lun\|Poon, Ronnie Tp\|Pang, Roberta Wc
PMID:	26396913

254.
Journal:	Oncotarget. 2015 Oct 27;6(33):34309-20.
Title:	TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells.
Author:	Liu, Xing\|Liao, Weijia\|Yuan, Qing\|Ou, Ying\|Huang, Jian
PMID:	26418879

255.
Journal:	Cell Prolif. 2015 Dec;48(6):691-704.
Title:	Blocking autophagy enhances meloxicam lethality to hepatocellular carcinoma by promotion of endoplasmic reticulum stress.
Author:	Zhong, Jingtao\|Dong, Xiaofeng\|Xiu, Peng\|Wang, Fuhai\|Liu, Ju\|Wei, Honglong\|Xu, Zongzhen\|Liu, Feng\|Li, Tao\|Li, Jie
PMID:	26481188

256.
Journal:	Pathologe. 2015 Nov;36 Suppl 2:210-5.
Title:	[Molecular and metabolic changes in human clear cell liver foci].
Author:	Ribback, S\|Calvisi, D F\|Cigliano, A\|Rausch, J\|Heidecke, C-D\|Birth, M\|Dombrowski, F
PMID:	26483250

257.
Journal:	World J Gastroenterol. 2015 Oct 21;21(39):11185-98.
Title:	Managements of recurrent hepatocellular carcinoma after liver transplantation: A systematic review.
Author:	de'Angelis, Nicola\|Landi, Filippo\|Carra, Maria Clotilde\|Azoulay, Daniel
PMID:	26494973

258.
Journal:	Int J Oncol. 2015 Dec;47(6):2240-6.
Title:	Sedanolide induces autophagy through the PI3K, p53 and NF-kappaB signaling pathways in human liver cancer cells.
Author:	Hsieh, Shu-Ling\|Chen, Chi-Tsai\|Wang, Jyh-Jye\|Kuo, Yu-Hao\|Li, Chien-Chun\|Hsieh, Lan-Chi\|Wu, Chih-Chung
PMID:	26500073

259.
Journal:	J Cancer. 2015 Sep 16;6(12):1195-205.
Title:	Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma.
Author:	Ewald, Florian\|Norz, Dominik\|Grottke, Astrid\|Bach, Johanna\|Herzberger, Christiane\|Hofmann, Bianca T\|Nashan, Bjorn\|Jucker, Manfred
PMID:	26535060

260.
Journal:	Oncotarget. 2015 Dec 15;6(40):42813-24.
Title:	LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway.
Author:	Ji, Jie\|Tang, Junwei\|Deng, Lei\|Xie, Yu\|Jiang, Runqiu\|Li, Guoqiang\|Sun, Beicheng
PMID:	26540343

261.
Journal:	Curr Clin Pharmacol. 2015;10(4):299-304.
Title:	Advances in the Pharmacologic Treatment of Hepatocellular Carcinoma.
Author:	Bhayani, Neil H\|Jiang, Yixing\|Hamed, Osama\|Kimchi, Eric T\|Staveley-O'Carroll, Kevin F\|Gusani, Niraj J
PMID:	26548906

262.
Journal:	Oncotarget. 2015 Dec 15;6(40):42923-37.
Title:	Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer.
Author:	Chen, Wei-Ching\|Chang, Yung-Sheng\|Hsu, Hui-Ping\|Yen, Meng-Chi\|Huang, Hau-Lun\|Cho, Chien-Yu\|Wang, Chih-Yang\|Weng, Tzu-Yang\|Lai, Po-Ting\|Chen, Ching-Shih\|Lin, Yih-Jyh\|Lai, Ming-Derg
PMID:	26556861

263.
Journal:	World J Gastroenterol. 2015 Nov 14;21(42):12059-70.
Title:	Sorafenib-based combined molecule targeting in treatment of hepatocellular carcinoma.
Author:	Gao, Jian-Jun\|Shi, Zhen-Yan\|Xia, Ju-Feng\|Inagaki, Yoshinori\|Tang, Wei
PMID:	26576091

264.
Journal:	Biochem Biophys Res Commun. 2015 Dec 25;468(4):684-90.
Title:	Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.
Author:	Murata, Yasuhiko\|Uehara, Yoshihiko\|Hosoi, Yoshio
PMID:	26585486

265.
Journal:	Phytomedicine. 2015 Dec 1;22(13):1139-49.
Title:	Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells.
Author:	Shi, Ya-Min\|Yang, Lei\|Geng, Ya-Di\|Zhang, Chao\|Kong, Ling-Yi
PMID:	26598912

266.
Journal:	Int J Clin Exp Pathol. 2015 Nov 1;8(11):14383-91. eCollection 2015.
Title:	HRP-3 protects the hepatoma cells from glucose deprivation-induced apoptosis.
Author:	Cai, Hao\|Jiang, Deke\|Qi, Fang\|Xu, Jianfeng\|Yu, Long\|Xiao, Qianyi
PMID:	26823754

267.
Journal:	Cell Death Discov. 2015 Sep 7;1:15016.
Title:	mTORC2 controls cancer cell survival by modulating gluconeogenesis.
Author:	Khan, M W\|Biswas, D\|Ghosh, M\|Mandloi, S\|Chakrabarti, S\|Chakrabarti, P
PMID:	27551450

268.
Journal:	Cell Death Discov. 2015 Nov 30;1:15051.
Title:	Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling.
Author:	Tsai, M-C\|Chen, K-D\|Wang, C-C\|Huang, K-T\|Wu, C-H\|Kuo, I-Y\|Chen, L-Y\|Hu, T-H\|Goto, S\|Nakano, T\|Dorling, A\|McVey, J H\|Chen, C-L\|Lin, C-C
PMID:	27551480

269.
Journal:	Eur J Cancer Prev. 2016 Jan;25(1):54-64.
Title:	Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1.
Author:	Lee, Jong Doo\|Choi, Min-Ah\|Ro, Simon Weonsang\|Yang, Woo Ick\|Cho, Arthur E H\|Ju, Hye-Lim\|Baek, Sinhwa\|Chung, Sook In\|Kang, Won Jun\|Yun, Mijin\|Park, Jeon Han
PMID:	25747515

270.
Journal:	Anticancer Agents Med Chem. 2016;16(1):29-37.
Title:	Potential Molecular Targeted Therapeutics: Role of PI3-K/Akt/mTOR Inhibition in Cancer.
Author:	Sokolowski, Kevin M\|Koprowski, Steven\|Kunnimalaiyaan, Selvi\|Balamurugan, Mariappan\|Gamblin, T Clark\|Kunnimalaiyaan, Muthusamy
PMID:	26179270

271.
Journal:	Clin Res Hepatol Gastroenterol. 2016 Feb;40(1):9-14.
Title:	TERT promoter mutations in primary liver tumors.
Author:	Nault, Jean-Charles\|Zucman-Rossi, Jessica
PMID:	26336998

272.
Journal:	J Hepatol. 2016 Mar;64(3):609-17.
Title:	Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.
Author:	Govaere, Olivier\|Wouters, Jasper\|Petz, Michaela\|Vandewynckel, Yves-Paul\|Van den Eynde, Kathleen\|Van den Broeck, Anke\|Verhulst, Stefaan\|Dolle, Laurent\|Gremeaux, Lies\|Ceulemans, An\|Nevens, Frederik\|van Grunsven, Leo A\|Topal, Baki\|Vankelecom, Hugo\|Giannelli,
PMID:	26592953

273.
Journal:	Eur J Pharmacol. 2016 Jan 15;771:130-8.
Title:	ZT-25, a new vacuolar H(+)-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells.
Author:	Lu, Yapeng\|Zhang, Rui\|Liu, Siyuan\|Zhao, Yu\|Gao, Jing\|Zhu, Li
PMID:	26689625

274.
Journal:	Liver Int. 2016 Aug;36(8):1176-86.
Title:	Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.
Author:	Wang, Chunmei\|Che, Li\|Hu, Junjie\|Zhang, Shanshan\|Jiang, Lijie\|Latte, Gavinella\|Demartis, Maria I\|Tao, Junyan\|Gui, Bing\|Pilo, Maria G\|Ribback, Silvia\|Dombrowski, Frank\|Evert, Matthias\|Calvisi, Diego F\|Chen, Xin
PMID:	26716908

275.
Journal:	Oncol Rep. 2016 Feb;35(2):625-38.
Title:	Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review).
Author:	Zhang, Xiao\|Wang, Yulan\|Wang, Jiayi\|Sun, Fenyong
PMID:	26717966

276.
Journal:	PLoS One. 2016 Jan 4;11(1):e0145195.
Title:	Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent.
Author:	Lv, Huiqing\|Zhang, Zhongmin\|Wu, Xiaoyu\|Wang, Yaoxia\|Li, Chenglin\|Gong, Weihong\|Gui, Liang\|Wang, Xin
PMID:	26727592

277.
Journal:	Oncotarget. 2016 Mar 1;7(9):9718-31.
Title:	The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma.
Author:	Pivonello, Claudia\|Negri, Mariarosaria\|De Martino, Maria Cristina\|Napolitano, Maria\|de Angelis, Cristina\|Provvisiero, Donatella Paola\|Cuomo, Gaia\|Auriemma, Renata Simona\|Simeoli, Chiara\|Izzo, Francesco\|Colao, Annamaria\|Hofland, Leo J\|Pivonello, Rosario
PMID:	26756219

278.
Journal:	Oncotarget. 2016 Feb 9;7(6):7207-15.
Title:	MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.
Author:	Tomonari, Tetsu\|Takeishi, Shunsaku\|Taniguchi, Tatsuya\|Tanaka, Takahiro\|Tanaka, Hironori\|Fujimoto, Shota\|Kimura, Tetsuo\|Okamoto, Koichi\|Miyamoto, Hiroshi\|Muguruma, Naoki\|Takayama, Tetsuji
PMID:	26769852

279.
Journal:	Cell Cycle. 2016;15(4):573-83.
Title:	A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells.
Author:	Augello, Giuseppa\|Puleio, Roberto\|Emma, Maria Rita\|Cusimano, Antonella\|Loria, Guido R\|McCubrey, James A\|Montalto, Giuseppe\|Cervello, Melchiorre
PMID:	26794644

280.
Journal:	Oncotarget. 2016 Mar 1;7(9):9832-43.
Title:	RB/PLK1-dependent induced pathway by SLAMF3 expression inhibits mitosis and control hepatocarcinoma cell proliferation.
Author:	Bouhlal, Hicham\|Ouled-Haddou, Hakim\|Debuysscher, Veronique\|Singh, Amrathlal Rabbind\|Ossart, Christele\|Reignier, Aline\|Hocini, Hakim\|Fouquet, Gregory\|Al Baghami, Mohammed\|Eugenio, Melanie Simoes\|Nguyen-Khac, Eric\|Regimbeau, Jean-Marc\|Marcq, Ingrid
PMID:	26799423

281.
Journal:	Oncol Rep. 2016 Apr;35(4):2081-8.
Title:	YL4073 is a potent autophagy-stimulating antitumor agent in an in vivo model of Lewis lung carcinoma.
Author:	Xu, You-Zhi\|Li, Yong-Huai\|Lu, Wen-Jie\|Lu, Kun\|Wang, Chun-Ting\|Li, Yan\|Lin, Hong-Jun\|Kan, Li-Xin\|Yang, Sheng-Yong\|Wang, Si-Ying\|Zhao, Ying-Lan
PMID:	26847587

282.
Journal:	Sci Rep. 2016 Feb 9;6:20484.
Title:	Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice.
Author:	Hu, Junjie\|Che, Li\|Li, Lei\|Pilo, Maria G\|Cigliano, Antonio\|Ribback, Silvia\|Li, Xiaolei\|Latte, Gavinella\|Mela, Marta\|Evert, Matthias\|Dombrowski, Frank\|Zheng, Guohua\|Chen, Xin\|Calvisi, Diego F
PMID:	26857837

283.
Journal:	World J Gastroenterol. 2016 Feb 14;22(6):2071-80.
Title:	Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.
Author:	Ding, Ning\|Che, Li\|Li, Xiao-Lei\|Liu, Yan\|Jiang, Li-Jie\|Fan, Biao\|Tao, Jun-Yan\|Chen, Xin\|Ji, Jia-Fu
PMID:	26877611

284.
Journal:	Oncotarget. 2016 Mar 22;7(12):14429-40.
Title:	HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas.
Author:	Zhu, Yu\|Zhang, Xuebin\|Qi, Lisha\|Cai, Ying\|Yang, Ping\|Xuan, Geng\|Jiang, Yuan
PMID:	26894862

285.
Journal:	Mol Pharm. 2016 Apr 4;13(4):1298-307.
Title:	Codelivery of Doxorubicin and shAkt1 by Poly(ethylenimine)-Glycyrrhetinic Acid Nanoparticles To Induce Autophagy-Mediated Liver Cancer Combination Therapy.
Author:	Wang, Feng-Zhen\|Xing, Lei\|Tang, Zheng-hai\|Lu, Jin-Jian\|Cui, Peng-Fei\|Qiao, Jian-Bing\|Jiang, Lei\|Jiang, Hu-Lin\|Zong, Li
PMID:	26894988

286.
Journal:	Tumour Biol. 2016 Aug;37(8):11039-48.
Title:	C6 ceramide sensitizes the anti-hepatocellular carcinoma (HCC) activity by AZD-8055, a novel mTORC1/2 dual inhibitor.
Author:	Liu, Mo\|Gu, Peng\|Guo, Wenjia\|Fan, Xiwen
PMID:	26897748

287.
Journal:	Hepatology. 2016 Mar;63(3):813-26.
Title:	PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.
Author:	Samarin, Jana\|Laketa, Vibor\|Malz, Mona\|Roessler, Stephanie\|Stein, Ilan\|Horwitz, Elad\|Singer, Stephan\|Dimou, Eleni\|Cigliano, Antonio\|Bissinger, Michaela\|Falk, Christine Susanne\|Chen, Xin\|Dooley, Steven\|Pikarsky, Eli\|Calvisi, Diego Francesco\|Schultz, Carste
PMID:	26901106

288.
Journal:	Carcinogenesis. 2016 Apr;37(4):408-419.
Title:	Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma.
Author:	Francois-Vaughan, Heather\|Adebayo, Adeola O\|Brilliant, Kate E\|Parry, Nicola M A\|Gruppuso, Philip A\|Sanders, Jennifer A
PMID:	26905589

289.
Journal:	Hepatology. 2016 Jun;63(6):1928-42.
Title:	MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription.
Author:	Li, Yue\|Tsang, Chi Kwan\|Wang, Suihai\|Li, Xiao-Xing\|Yang, Yang\|Fu, Liwu\|Huang, Wenlin\|Li, Ming\|Wang, Hui-Yun\|Zheng, X F Steven
PMID:	26910647

290.
Journal:	Oncotarget. 2016 Mar 29;7(13):16349-61.
Title:	AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin.
Author:	Gao, Mei\|Kong, Qingbin\|Hua, Hui\|Yin, Yancun\|Wang, Jiao\|Luo, Ting\|Jiang, Yangfu
PMID:	26918349

291.
Journal:	Oncotarget. 2016 Apr 5;7(14):18229-46.
Title:	Liver fatty acid-binding protein (L-FABP) promotes cellular angiogenesis and migration in hepatocellular carcinoma.
Author:	Ku, Chung-Yu\|Liu, Yu-Huei\|Lin, Hsuan-Yuan\|Lu, Shao-Chun\|Lin, Jung-Yaw
PMID:	26919097

292.
Journal:	Hepatol Res. 2016 Dec;46(13):1380-1391.
Title:	Associations of components of PTEN/AKT/mTOR pathway with cancer stem cell markers and prognostic value of these biomarkers in hepatocellular carcinoma.
Author:	Su, Rujuan\|Nan, Haocheng\|Guo, Hui\|Ruan, Zhiping\|Jiang, Lili\|Song, Yuanyuan\|Nan, Kejun
PMID:	26932478

293.
Journal:	Oncotarget. 2016 Mar 29;7(13):17047-59.
Title:	KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms.
Author:	Chen, Min-Bin\|Zhou, Zhen-Tao\|Yang, Lan\|Wei, Mu-Xin\|Tang, Min\|Ruan, Ting-Yan\|Xu, Jun-Ying\|Zhou, Xiao-Zhong\|Chen, Gang\|Lu, Pei-Hua
PMID:	26933997

294.
Journal:	Int J Oncol. 2016 May;48(5):1868-76.
Title:	Corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway in vitro and in vivo.
Author:	Gu, Yue\|Xiao, Linfeng\|Ming, Yanlin\|Zheng, Zhizhong\|Li, Wengang
PMID:	26935808

295.
Journal:	Oncotarget. 2016 May 3;7(18):25087-102.
Title:	Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections.
Author:	Tornesello, Maria Lina\|Buonaguro, Luigi\|Izzo, Francesco\|Buonaguro, Franco M
PMID:	26943571

296.
Journal:	Oncotarget. 2016 Apr 12;7(15):20193-208.
Title:	Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1alpha via the PI3K/AKT/mTOR pathway.
Author:	Wang, Haiyong\|Zhang, Chenyue\|Xu, Litao\|Zang, Kun\|Ning, Zhouyu\|Jiang, Feng\|Chi, Huiying\|Zhu, Xiaoyan\|Meng, Zhiqiang
PMID:	26958938

297.
Journal:	Cancer Biol Ther. 2016 Apr 2;17(4):457-66.
Title:	Ganetespib radiosensitization for liver cancer therapy.
Author:	Chettiar, Sivarajan T\|Malek, Reem\|Annadanam, Anvesh\|Nugent, Katriana M\|Kato, Yoshinori\|Wang, Hailun\|Cades, Jessica A\|Taparra, Kekoa\|Belcaid, Zineb\|Ballew, Matthew\|Manmiller, Sarah\|Proia, David\|Lim, Michael\|Anders, Robert A\|Herman, Joseph M\|Tran, Phuoc T
PMID:	26980196

298.
Journal:	J Ethnopharmacol. 2016 Jun 20;186:143-150.
Title:	Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling.
Author:	Hu, Zhongdong\|Yang, Ailin\|Fan, Haitao\|Wang, Ying\|Zhao, Yunfang\|Zha, Xiaojun\|Zhang, Hongbing\|Tu, Pengfei
PMID:	27045863

299.
Journal:	Oncotarget. 2016 May 31;7(22):32221-31.
Title:	Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells.
Author:	You, Yang\|Zheng, Qiongdan\|Dong, Yinying\|Xie, Xiaoying\|Wang, Yaohui\|Wu, Sifan\|Zhang, Lan\|Wang, Yingcong\|Xue, Tongchun\|Wang, Zhiming\|Chen, Rongxin\|Wang, Yanhong\|Cui, Jiefeng\|Ren, Zhenggang
PMID:	27050147

300.
Journal:	J Exp Clin Cancer Res. 2016 Apr 11;35:65.
Title:	EphA1 activation promotes the homing of endothelial progenitor cells to hepatocellular carcinoma for tumor neovascularization through the SDF-1/CXCR4 signaling pathway.
Author:	Wang, Yi\|Yu, Haitao\|Shan, Yunfeng\|Tao, Chonglin\|Wu, Fang\|Yu, Zhengping\|Guo, Pengyi\|Huang, Jianfei\|Li, Junjian\|Zhu, Qiandong\|Yu, Fuxiang\|Song, Qitong\|Shi, Hongqi\|Zhou, Mengtao\|Chen, Gang
PMID:	27066828

301.
Journal:	Biochem Biophys Res Commun. 2016 May 27;474(2):330-337.
Title:	MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models.
Author:	Wang, Kaifeng\|Fan, Yaohua\|Chen, Gongying\|Wang, Zhengrong\|Kong, Dexin\|Zhang, Peng
PMID:	27107695

302.
Journal:	Biochem Biophys Res Commun. 2016 May 27;474(2):351-356.
Title:	FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway.
Author:	Huang, Xiongfei\|Zeng, Yeting\|Wang, Xinrui\|Ma, Xiaoxiao\|Li, Qianqian\|Li, Ningbo\|Su, Hongying\|Huang, Wendong
PMID:	27109477

303.
Journal:	Clin Sci (Lond). 2016 Jul 1;130(13):1125-36.
Title:	Therapeutic inhibition of phospholipase D1 suppresses hepatocellular carcinoma.
Author:	Xiao, Junjie\|Sun, Qi\|Bei, Yihua\|Zhang, Ling\|Dimitrova-Shumkovska, Jasmina\|Lv, Dongchao\|Yang, Yuefeng\|Cao, Yan\|Zhao, Yingying\|Song, Meiyi\|Song, Yang\|Wang, Fei\|Yang, Changqing
PMID:	27129182

304.
Journal:	J Hepatol. 2016 Aug;65(2):296-304.
Title:	Integrative biomarker analyses indicate etiological variations in hepatocellular carcinoma.
Author:	Zhu, Andrew X\|Chen, David\|He, Wei\|Kanai, Masayuki\|Voi, Maurizio\|Chen, Li-Tzong\|Daniele, Bruno\|Furuse, Junji\|Kang, Yoon-Koo\|Poon, Ronnie T P\|Vogel, Arndt\|Chiang, Derek Y
PMID:	27130844

305.
Journal:	Korean J Physiol Pharmacol. 2016 May;20(3):237-43.
Title:	Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway.
Author:	Shi, Yang\|Song, Qingwei\|Hu, Dianhe\|Zhuang, Xiaohu\|Yu, Shengcai\|Teng, Dacai
PMID:	27162477

306.
Journal:	Oncotarget. 2016 Jun 14;7(24):36767-36782.
Title:	Des-gamma-carboxy prothrombin antagonizes the effects of Sorafenib on human hepatocellular carcinoma through activation of the Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways.
Author:	Cui, Shu-Xiang\|Shi, Wen-Na\|Song, Zhi-Yu\|Wang, Shu-Qing\|Yu, Xin-Feng\|Gao, Zu-Hua\|Qu, Xian-Jun
PMID:	27167344

307.
Journal:	Sci Signal. 2016 May 17;9(428):ra50.
Title:	BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism.
Author:	Xiao, Fei\|Deng, Jiali\|Guo, Yajie\|Niu, Yuguo\|Yuan, Feixiang\|Yu, Junjie\|Chen, Shanghai\|Guo, Feifan
PMID:	27188441

308.
Journal:	Cancer Res. 2016 Jul 15;76(14):4205-15.
Title:	Phenotypic and Signaling Consequences of a Novel Aberrantly Spliced Transcript FGF Receptor-3 in Hepatocellular Carcinoma.
Author:	Li, Ke\|Shen, Baiyong\|Cheng, Xi\|Ma, Ding\|Jing, Xiaoqian\|Liu, Xinyu\|Yang, Weiping\|Peng, Chenghong\|Qiu, Weihua
PMID:	27267910

309.
Journal:	Oncotarget. 2016 Jul 26;7(30):47403-47417.
Title:	Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma.
Author:	Watari, Kosuke\|Nishitani, Ayumi\|Shibata, Tomohiro\|Noda, Masaki\|Kawahara, Akihiko\|Akiba, Jun\|Murakami, Yuichi\|Yano, Hirohisa\|Kuwano, Michihiko\|Ono, Mayumi
PMID:	27329724

310.
Journal:	Chem Biol Interact. 2016 Aug 25;256:55-63.
Title:	Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins.
Author:	Qiu, Peiyu\|Man, Shuli\|Yang, He\|Fan, Wei\|Yu, Peng\|Gao, Wenyuan
PMID:	27369806

311.
Journal:	Crit Rev Oncol Hematol. 2016 Sep;105:65-72.
Title:	Hepatocellular carcinoma: Exploring the impact of ethnicity on molecular biology.
Author:	Lamarca, Angela\|Mendiola, Marta\|Barriuso, Jorge
PMID:	27372199

312.
Journal:	Front Pharmacol. 2016 Jun 8;7:151.
Title:	Modulation of Autophagy by Sorafenib: Effects on Treatment Response.
Author:	Prieto-Dominguez, Nestor\|Ordonez, Raquel\|Fernandez, Anna\|Garcia-Palomo, Andres\|Muntane, Jordi\|Gonzalez-Gallego, Javier\|Mauriz, Jose L
PMID:	27375485

313.
Journal:	Int J Biochem Cell Biol. 2016 Sep;78:52-62.
Title:	Inhibition of autophagy enhances effects of PF-04691502 on apoptosis and DNA damage of lung cancer cells.
Author:	Fei, Hong-Rong\|Tian, Hua-\|Zhou, Xiao-Lei\|Yang, Ming-Feng\|Sun, Bao-Liang\|Yang, Xiao-Yi\|Jiao, Peng-\|Wang, Feng-Ze
PMID:	27378731

314.
Journal:	Eur J Med Chem. 2016 Oct 21;122:684-701.
Title:	Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor.
Author:	Han, Jinsong\|Chen, Ying\|Yang, Chao\|Liu, Ting\|Wang, Mingping\|Xu, Haojie\|Zhang, Ling\|Zheng, Canhui\|Song, Yunlong\|Zhu, Ju
PMID:	27448924

315.
Journal:	Oncol Rep. 2016 Sep;36(3):1709-16.
Title:	MicroRNA-1207-5p inhibits hepatocellular carcinoma cell growth and invasion through the fatty acid synthase-mediated Akt/mTOR signalling pathway.
Author:	Zhao, Gang\|Dong, Lei\|Shi, Haitao\|Li, Hong\|Lu, Xiaolan\|Guo, Xiaoyan\|Wang, Jinhai
PMID:	27461404

316.
Journal:	World J Gastroenterol. 2016 Jul 21;22(27):6246-56.
Title:	Immunohistochemistry panel segregates molecular types of hepatocellular carcinoma in Brazilian autopsy cases.
Author:	Felipe-Silva, Aloisio\|Wakamatsu, Alda\|Dos Santos Cirqueira, Cinthya\|Alves, Venancio Avancini Ferreira
PMID:	27468214

317.
Journal:	Mol Cancer Ther. 2016 Nov;15(11):2553-2562.
Title:	Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma.
Author:	Singh, Alok R\|Joshi, Shweta\|Burgoyne, Adam M\|Sicklick, Jason K\|Ikeda, Sadakatsu\|Kono, Yuko\|Garlich, Joseph R\|Morales, Guillermo A\|Durden, Donald L
PMID:	27496136

318.
Journal:	Neoplasma. 2016;63(6):880-887.
Title:	Oxaliplatin-rapamycin combination was superior to mono-drug in treatment of hepatocellular carcinoma both in vitro and in vivo.
Author:	Li, X Z\|Sun, Y L\|Cao, L Q\|Li, M J
PMID:	27565326

319.
Journal:	Oncotarget. 2016 Sep 20;7(38):62647-62656.
Title:	Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantation.
Author:	Shen, Chuan\|Peng, Chenghong\|Shen, Baiyong\|Zhu, Zhecheng\|Xu, Ning\|Li, Tao\|Xie, Junjie
PMID:	27577068

320.
Journal:	J Pathol. 2016 Dec;240(4):450-460.
Title:	MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters.
Author:	Zhou, Hui-Chao\|Fang, Jian-Hong\|Shang, Li-Ru\|Zhang, Zi-Jun\|Sang, Ye\|Xu, Li\|Yuan, Yunfei\|Chen, Min-Shan\|Zheng, Limin\|Zhang, Yaojun\|Zhuang, Shi-Mei
PMID:	27577856

321.
Journal:	PLoS One. 2016 Sep 9;11(9):e0162634.
Title:	Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress.
Author:	Thompson, Scott M\|Callstrom, Matthew R\|Jondal, Danielle E\|Butters, Kim A\|Knudsen, Bruce E\|Anderson, Jill L\|Lien, Karen R\|Sutor, Shari L\|Lee, Ju-Seog\|Thorgeirsson, Snorri S\|Grande, Joseph P\|Roberts, Lewis R\|Woodrum, David A
PMID:	27611696

322.
Journal:	Biochem Biophys Res Commun. 2016 Oct 7;479(1):74-9.
Title:	Rapamycin regulates the proliferation of Huh7, a hepatocellular carcinoma cell line, by up-regulating p53 expression.
Author:	Kwon, Sora\|Jeon, Ji-Sook\|Ahn, Curie\|Sung, Jung-Suk\|Choi, Inho
PMID:	27616194

323.
Journal:	Am J Chin Med. 2016;44(6):1273-1288.
Title:	Solanum nigrum Suppress Angiogenesis-Mediated Tumor Growth Through Inhibition of the AKT/mTOR Pathway.
Author:	Yang, Mon-Yuan\|Hung, Chia-Hung\|Chang, Chun-Hua\|Tseng, Tsui-Hwa\|Wang, Chau-Jong
PMID:	27627922

324.
Journal:	Am J Cancer Res. 2016 Aug 1;6(8):1681-94. eCollection 2016.
Title:	Targeting PCDH20 gene by microRNA-122 confers 5-FU resistance in hepatic carcinoma.
Author:	Wang, Wei\|Liu, Wen Bin\|Huang, Da Bing\|Jia, Wei\|Ji, Chu Shu\|Hu, Bing
PMID:	27648358

325.
Journal:	BMC Cancer. 2016 Sep 21;16(1):742.
Title:	Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways.
Author:	Wang, Yu\|Nie, Hao\|Zhao, Xin\|Qin, Yong\|Gong, Xingguo
PMID:	27654866

326.
Journal:	Cell Death Dis. 2016 Oct 6;7(10):e2400.
Title:	P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy.
Author:	Jia, Yu-Li\|Xu, Meng\|Dou, Chang-Wei\|Liu, Zhi-Kui\|Xue, Yu-Mo\|Yao, Bo-Wen\|Ding, Ling-Long\|Tu, Kang-Sheng\|Zheng, Xin\|Liu, Qing-Guang
PMID:	27711074

327.
Journal:	Transl Oncol. 2016 Oct;9(5):466-471.
Title:	Loss of Tuberous Sclerosis Complex 2 (TSC2) as a Predictive Biomarker of Response to mTOR Inhibitor Treatment in Patients with Hepatocellular Carcinoma.
Author:	Cho, Jinhyun\|Lee, Jeeyun\|Kim, Jusun\|Kim, Seung Tae\|Lee, Sujin\|Kim, Sun Young\|Ha, Sang Yun\|Park, Cheol-Keun\|Lim, Ho Yeong
PMID:	27751352

328.
Journal:	Biochem Biophys Res Commun. 2016 Nov 18;480(3):334-340.
Title:	Autophagy prevention sensitizes AKTi-1/2-induced anti-hepatocellular carcinoma cell activity in vitro and in vivo.
Author:	Zhang, Qi\|Yang, Manyi\|Qu, Zhan\|Zhou, Jixiang\|Jiang, Qin
PMID:	27756618

329.
Journal:	Int J Oncol. 2016 Dec;49(6):2538-2548.
Title:	AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells.
Author:	Gong, Ling\|Di, Chunhong\|Xia, Xiaofang\|Wang, Jie\|Chen, Gongying\|Shi, Junping\|Chen, Pengshuai\|Xu, Hui\|Zhang, Weibing
PMID:	27779641

330.
Journal:	Sci Rep. 2016 Oct 27;6:35918.
Title:	Synthesis and biological evaluation of matrine derivatives containing benzo-alpha-pyrone structure as potent anti-lung cancer agents.
Author:	Wu, Lichuan\|Wang, Guizhen\|Liu, Shuaibing\|Wei, Jinrui\|Zhang, Sen\|Li, Ming\|Zhou, Guangbiao\|Wang, Lisheng
PMID:	27786281

331.
Journal:	Biomed Pharmacother. 2016 Dec;84:1202-1212.
Title:	The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways.
Author:	Xu, Ying\|Lv, Sheng-Xiang
PMID:	27788478

332.
Journal:	Oncotarget. 2016 Dec 6;7(49):80568-80578.
Title:	Metformin enhances the radiosensitivity of human liver cancer cells to gamma-rays and carbon ion beams.
Author:	Kim, Eun Ho\|Kim, Mi-Sook\|Furusawa, Yoshiya\|Uzawa, Akiko\|Han, Soorim\|Jung, Won-Gyun\|Sai, Sei
PMID:	27802188

333.
Journal:	Sci Rep. 2016 Nov 3;6:36318.
Title:	Evaluation of uttroside B, a saponin from Solanum nigrum Linn, as a promising chemotherapeutic agent against hepatocellular carcinoma.
Author:	Nath, Lekshmi R\|Gorantla, Jaggaiah N\|Thulasidasan, Arun Kumar T\|Vijayakurup, Vinod\|Shah, Shabna\|Anwer, Shabna\|Joseph, Sophia M\|Antony, Jayesh\|Veena, Kollery Suresh\|Sundaram, Sankar\|Marelli, Udaya K\|Lankalapalli, Ravi S\|Anto, Ruby John
PMID:	27808117

334.
Journal:	Transl Oncol. 2016 Dec;9(6):606-616.
Title:	AMPKalpha Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms.
Author:	Kopsiaftis, Stavros\|Hegde, Poornima\|Taylor, John A 3rd\|Claffey, Kevin P
PMID:	27916296

335.
Journal:	World J Gastroenterol. 2016 Dec 7;22(45):9921-9932.
Title:	Understanding the role of PIN1 in hepatocellular carcinoma.
Author:	Cheng, Chi-Wai\|Leong, Ka-Wai\|Tse, Eric
PMID:	28018099

336.
Journal:	Oncol Lett. 2016 Dec;12(6):4385-4392.
Title:	Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells.
Author:	Liu, Jie\|Ren, Hao\|Liu, Bin\|Zhang, Qingyu\|Li, Mingyi\|Zhu, Runzhi
PMID:	28101201

337.
Journal:	Crit Rev Oncog. 2016;21(5-6):413-432.
Title:	Antitumoral Activity of Sorafenib in Hepatocellular Carcinoma: Effects on Cell Survival and Death Pathways, Cell Metabolism Reprogramming, and Nitrosative and Oxidative Stress.
Author:	Molina-Ruiz, Francisco J\|Gonzalez, Raul\|Rodriguez-Hernandez, Maria A\|Navarro-Villaran, Elena\|Padillo, Francisco J\|Muntane, Jordi
PMID:	29431086

338.
Journal:	Anticancer Agents Med Chem. 2017;17(1):143-149.
Title:	Cordycepin Affects Multiple Apoptotic Pathways to Mediate Hepatocellular Carcinoma Cell Death.
Author:	Zhou, Yulin\|Guo, Zhihua\|Meng, Qingfan\|Lu, Jiahui\|Wang, Ning\|Liu, Hui\|Liang, Qiming\|Quan, Yutong\|Wang, Di\|Xie, Jing
PMID:	27225448

339.
Journal:	Curr Cancer Drug Targets. 2017;17(4):386-401.
Title:	Inhibition of Aurora A Kinase by Alisertib Induces Autophagy and Cell Cycle Arrest and Increases Chemosensitivity in Human Hepatocellular Carcinoma HepG2 Cells.
Author:	Zhu, Qiaohua\|Yu, Xinfa\|Zhou, Zhi-Wei\|Zhou, Chengyu\|Chen, Xiao-Wu\|Zhou, Shu-Feng
PMID:	27396604

340.
Journal:	J Pineal Res. 2017 Jan;62(1).
Title:	Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Author:	Sanchez, Diana I\|Gonzalez-Fernandez, Barbara\|San-Miguel, Beatriz\|de Urbina, Juan Ortiz\|Crespo, Irene\|Gonzalez-Gallego, Javier\|Tunon, Maria J
PMID:	27696512

341.
Journal:	Acta Pharmacol Sin. 2017 Jan;38(1):120-132.
Title:	A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways.
Author:	Liu, Ying\|Qi, Yang\|Bai, Zhi-Hui\|Ni, Chen-Xu\|Ren, Qi-Hui\|Xu, Wei-Heng\|Xu, Jing\|Hu, Hong-Gang\|Qiu, Lei\|Li, Jian-Zhong\|He, Zhi-Gao\|Zhang, Jun-Ping
PMID:	27773936

342.
Journal:	Clin Sci (Lond). 2017 Jan 1;131(1):27-36.
Title:	Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis.
Author:	Cauchy, Francois\|Mebarki, Mouniya\|Leporq, Benjamin\|Laouirem, Samira\|Albuquerque, Miguel\|Lambert, Simon\|Bourgoin, Pierre\|Soubrane, Olivier\|Van Beers, Bernard E\|Faivre, Sandrine\|Bedossa, Pierre\|Paradis, Valerie
PMID:	27803295

343.
Journal:	Appl Microbiol Biotechnol. 2017 Feb;101(4):1535-1546.
Title:	C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells.
Author:	Jiang, Shanshan\|Wang, Qian\|Feng, Meiqing\|Li, Jiyang\|Guan, Zhongbin\|An, Duopeng\|Dong, Mengxue\|Peng, Yuzhe\|Kuerban, Kudelaidi\|Ye, Li
PMID:	27807662

344.
Journal:	Clin Res Hepatol Gastroenterol. 2017 Mar;41(2):197-203.
Title:	Combination of temsirolimus and adriamycin exhibits an enhanced antitumor effect in hepatocellular carcinoma.
Author:	Kang, Hong-Gang\|Wang, Bao-Zhong\|Zhang, Jing\|Liu, Mei-Rong\|Li, Ying-Xue
PMID:	27863926

345.
Journal:	Chem Biol Interact. 2017 Jan 5;261:108-117.
Title:	Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells.
Author:	Kim, Young Woo\|Jang, Eun Jeong\|Kim, Chang-Hyun\|Lee, Ju-Hee
PMID:	27871897

346.
Journal:	Cancer Sci. 2017 Feb;108(2):267-276.
Title:	Sialyltransferase ST3GAL6 mediates the effect of microRNA-26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway.
Author:	Sun, Mingming\|Zhao, Xuzi\|Liang, Leilei\|Pan, Xufeng\|Lv, Hao\|Zhao, Yongfu
PMID:	27906498

347.
Journal:	Oncotarget. 2017 Jan 10;8(2):2936-2948.
Title:	Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells.
Author:	Kim, Jong-Ok\|Kim, Kee-Hwan\|Song, In Sang\|Cheon, Kwang-Sik\|Kim, Ok-Hee\|Lee, Sang Chul\|Lee, Sang Kuon\|Kim, Say-June
PMID:	27935857

348.
Journal:	Gene Expr. 2017 Feb 10;17(2):129-140.
Title:	Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production.
Author:	Reyes, Ryan\|Wani, Nissar A\|Ghoshal, Kalpana\|Jacob, Samson T\|Motiwala, Tasneem
PMID:	27938509

349.
Journal:	Int J Oncol. 2017 Jan;50(1):297-309.
Title:	Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway.
Author:	Ling, Sunbin\|Song, Lei\|Fan, Ning\|Feng, Tingting\|Liu, Lu\|Yang, Xu\|Wang, Mingjie\|Li, Yanling\|Tian, Yu\|Zhao, Feng\|Liu, Ying\|Huang, Qihong\|Hou, Zhaoyuan\|Xu, Fei\|Shi, Lei\|Li, Yan
PMID:	27959383

350.
Journal:	Cancer Res. 2017 Mar 1;77(5):1155-1167.
Title:	Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation.
Author:	Malakar, Pushkar\|Shilo, Asaf\|Mogilevsky, Adi\|Stein, Ilan\|Pikarsky, Eli\|Nevo, Yuval\|Benyamini, Hadar\|Elgavish, Sharona\|Zong, Xinying\|Prasanth, Kannanganattu V\|Karni, Rotem
PMID:	27993818

351.
Journal:	Biochem Biophys Res Commun. 2017 Jan 29;483(1):630-637.
Title:	MiR-223 modulates hepatocellular carcinoma cell proliferation through promoting apoptosis via the Rab1-mediated mTOR activation.
Author:	Dong, Zheng\|Qi, Ruizhao\|Guo, Xiaodong\|Zhao, Xin\|Li, Yinyin\|Zeng, Zhen\|Bai, Wenlin\|Chang, Xiujuan\|Hao, Liyan\|Chen, Yan\|Lou, Min\|Li, Zhiwei\|Lu, Yinying
PMID:	27998765

352.
Journal:	Oncotarget. 2017 Feb 7;8(6):9466-9475.
Title:	Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells.
Author:	Zhen, Mao-Chuan\|Wang, Fu-Qiang\|Wu, Shao-Feng\|Zhao, Yi-Lin\|Liu, Ping-Guo\|Yin, Zhen-Yu
PMID:	28036295

353.
Journal:	PLoS One. 2017 Jan 6;12(1):e0169439.
Title:	Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis.
Author:	Lu, Min\|Zessin, Amelia S\|Glover, Wayne\|Hsu, David S
PMID:	28060954

354.
Journal:	Anticancer Drugs. 2017 Apr;28(4):427-435.
Title:	AKT activation was not essential for hepatocellular carcinoma cell survival under glucose deprivation.
Author:	Zhou, Jing\|Tang, Yue\|Xie, Ze-Jun\|Lu, Jing-Ning\|Deng, Jing-Huan\|Huang, Xiao-Wei\|Chuan Hooi, Shing\|He, Min\|Lu, Guo-Dong
PMID:	28085697

355.
Journal:	Int J Oncol. 2017 Mar;50(3):975-983.
Title:	miR-345 inhibits tumor metastasis and EMT by targeting IRF1-mediated mTOR/STAT3/AKT pathway in hepatocellular carcinoma.
Author:	Yu, Miao\|Xue, Huanzhou\|Wang, Yadong\|Shen, Quan\|Jiang, Qingfeng\|Zhang, Xiao\|Li, Ke\|Jia, Meng\|Jia, Jiangkun\|Xu, Jian\|Tian, Yuwei
PMID:	28098858

356.
Journal:	Autophagy. 2017 Apr 3;13(4):730-738.
Title:	MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential.
Author:	Sun, Chao\|Liu, Xiongxiong\|Di, Cuixia\|Wang, Zhenhua\|Mi, Xiangquan\|Liu, Yang\|Zhao, Qiuyue\|Mao, Aihong\|Chen, Weiqiang\|Gan, Lu\|Zhang, Hong
PMID:	28121478

357.
Journal:	Oncotarget. 2017 Apr 18;8(16):26041-26056.
Title:	Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma.
Author:	Adebayo Michael, Adeola O\|Ahsan, Nagib\|Zabala, Valerie\|Francois-Vaughan, Heather\|Post, Stephanie\|Brilliant, Kate E\|Salomon, Arthur R\|Sanders, Jennifer A\|Gruppuso, Philip A
PMID:	28199961

358.
Journal:	Cancer Lett. 2017 Jun 1;395:63-71.
Title:	BCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade.
Author:	Liu, Xiaolong\|Hu, Xiaotong\|Kuang, Yeye\|Yan, Peijian\|Li, Lili\|Li, Chen\|Tao, Qian\|Cai, Xiujun
PMID:	28259820

359.
Journal:	J Pharm Pharmacol. 2017 Jun;69(6):743-752.
Title:	Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy.
Author:	Wang, Meng\|Huang, Can\|Su, Yong\|Yang, Cui\|Xia, Quan\|Xu, Du-Juan
PMID:	28266023

360.
Journal:	Oncol Res. 2017 Nov 2;25(9):1543-1553.
Title:	Inhibition of MMP-2 Expression Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinoma by Suppressing the PI3K/AKT/mTOR Pathway.
Author:	Tan, Wenliang\|Zhu, Sicong\|Cao, Jun\|Zhang, Lei\|Li, Wenda\|Liu, Kairui\|Zhong, Jinyi\|Shang, Changzhen\|Chen, Yajin
PMID:	28276313

361.
Journal:	BMC Cancer. 2017 Mar 16;17(1):197.
Title:	Objective response to mTOR inhibition in a metastatic collision tumor of the liver composed of melanoma and adenocarcinoma with TSC1 loss: a case report.
Author:	Bhangoo, Munveer S\|Zhou, Jenny Y\|Ali, Siraj M\|Madison, Russell\|Schrock, Alexa B\|Costantini, Carrie
PMID:	28302097

362.
Journal:	Anticancer Res. 2017 Mar;37(3):1083-1090.
Title:	Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma.
Author:	Komatsu, Hisateru\|Masuda, Takaaki\|Iguchi, Tomohiro\|Nambara, Sho\|Sato, Kuniaki\|Hu, Quingjang\|Hirata, Hidenari\|Ito, Shuhei\|Eguchi, Hidetoshi\|Sugimachi, Keishi\|Eguchi, Hidetoshi\|Doki, Yuichiro\|Mori, Masaki\|Mimori, Koshi
PMID:	28314268

363.
Journal:	Cell Death Dis. 2017 Mar 23;8(3):e2688.
Title:	Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway.
Author:	Wang, Shanshan S\|Chen, Yuhan H\|Chen, Ning\|Wang, Lijun J\|Chen, Dexi X\|Weng, Honglei L\|Dooley, Steven\|Ding, Huiguo G
PMID:	28333142

364.
Journal:	PLoS One. 2017 Mar 23;12(3):e0173252.
Title:	CC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo.
Author:	Xie, Zichen\|Wang, Jiqin\|Liu, Mei\|Chen, Deshan\|Qiu, Chao\|Sun, Keyu
PMID:	28334043

365.
Journal:	Oncogene. 2017 Aug;36(31):4415-4426.
Title:	Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice.
Author:	Chen, H\|Cai, W\|Chu, E S H\|Tang, J\|Wong, C-C\|Wong, S H\|Sun, W\|Liang, Q\|Fang, J\|Sun, Z\|Yu, J
PMID:	28346420

366.
Journal:	Biochem Biophys Res Commun. 2017 Jun 3;487(3):494-499.
Title:	The anti-hepatocellular carcinoma cell activity by a novel mTOR kinase inhibitor CZ415.
Author:	Zhang, Wei\|Chen, Bingyu\|Zhang, Yu\|Li, Kaiqiang\|Hao, Ke\|Jiang, Luxi\|Wang, Ying\|Mou, Xiaozhou\|Xu, Xiaodong\|Wang, Zhen
PMID:	28366631

367.
Journal:	Biotechnol Bioeng. 2017 Aug;114(8):1865-1877.
Title:	Bioengineered three-dimensional co-culture of cancer cells and endothelial cells: A model system for dual analysis of tumor growth and angiogenesis.
Author:	Chiew, Geraldine Giap Ying\|Wei, Na\|Sultania, Samiksha\|Lim, Sierin\|Luo, Kathy Qian
PMID:	28369747

368.
Journal:	Hepatology. 2017 Jul;66(1):167-181.
Title:	A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.
Author:	Liu, Pin\|Ge, Mengmeng\|Hu, Junjie\|Li, Xiaolei\|Che, Li\|Sun, Kun\|Cheng, Lili\|Huang, Yuedong\|Pilo, Maria G\|Cigliano, Antonio\|Pes, Giovanni M\|Pascale, Rosa M\|Brozzetti, Stefania\|Vidili, Gianpaolo\|Porcu, Alberto\|Cossu, Antonio\|Palmieri, Giuseppe\|Sini, Maria C\|R
PMID:	28370287

369.
Journal:	Sci Rep. 2017 Apr 7;7:46134.
Title:	Lanatoside C, a cardiac glycoside, acts through protein kinase Cdelta to cause apoptosis of human hepatocellular carcinoma cells.
Author:	Chao, Min-Wu\|Chen, Tzu-Hsuan\|Huang, Han-Li\|Chang, Yu-Wei\|HuangFu, Wei-Chun\|Lee, Yu-Ching\|Teng, Che-Ming\|Pan, Shiow-Lin
PMID:	28387249

370.
Journal:	Am J Cancer Res. 2017 Mar 1;7(3):565-573. eCollection 2017.
Title:	NRSN2 promotes osteosarcoma cell proliferation and growth through PI3K/Akt/MTOR and Wnt/beta-catenin signaling.
Author:	Keremu, Ajimu\|Maimaiti, Xiayimaierdan\|Aimaiti, Abudusaimi\|Yushan, Maimaiaili\|Alike, Yamuhanmode\|Yilihamu, Yilizati\|Yusufu, Aihemaitijiang
PMID:	28401012

371.
Journal:	Mol Immunol. 2017 Jul;87:132-140.
Title:	IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway.
Author:	Li, Ting-Ting\|Zhu, Di\|Mou, Tong\|Guo, Zhen\|Pu, Jun-Liang\|Chen, Qing-Song\|Wei, Xu-Fu\|Wu, Zhong-Jun
PMID:	28433890

372.
Journal:	Biochem Biophys Res Commun. 2017 Jun 3;487(3):709-715.
Title:	miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway.
Author:	Kim, Jihye\|Jiang, Jinmai\|Badawi, Mohamed\|Schmittgen, Thomas D
PMID:	28442344

373.
Journal:	Oncotarget. 2017 Apr 11;8(15):24777-24784.
Title:	STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells.
Author:	Li, Man\|Jin, Rui\|Wang, Weihua\|Zhang, Tieying\|Sang, Jiao\|Li, Na\|Han, Qunying\|Zhao, Wenxuan\|Li, Chunyan\|Liu, Zhengwen
PMID:	28445971

374.
Journal:	Cell Physiol Biochem. 2017;41(6):2289-2306.
Title:	Alpha1-ACT Functions as a Tumour Suppressor in Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Signalling Pathway via Activation of PTEN.
Author:	Zhu, Hanzhang\|Liu, Qiaoyu\|Tang, Junwei\|Xie, Yu\|Xu, Xiaoliang\|Huang, Ruyi\|Zhang, Yuanguangyan\|Jin, Kangpeng\|Sun, Beicheng
PMID:	28456796

375.
Journal:	Breast Cancer. 2017 Jul;24(4):521-527.
Title:	The role of miR-130a in cancer.
Author:	Zhang, He-da\|Jiang, Lin-Hong\|Sun, Da-Wei\|Li, Jian\|Ji, Zhen-Ling
PMID:	28477068

376.
Journal:	Mol Cell Proteomics. 2017 Aug;16(8):1475-1490.
Title:	Differential Proteomic Analysis of Gender-dependent Hepatic Tumorigenesis in Hras12V Transgenic Mice.
Author:	Rong, Zhuona\|Fan, Tingting\|Li, Huiling\|Li, Juan\|Wang, Kangwei\|Wang, Xinxin\|Dong, Jianyi\|Chen, Jun\|Wang, Fujin\|Wang, Jingyu\|Wang, Aiguo
PMID:	28512230

377.
Journal:	Anticancer Drugs. 2017 Aug;28(7):771-780.
Title:	Hypoxia as a target for drug combination therapy of liver cancer.
Author:	Bowyer, Cressida\|Lewis, Andrew L\|Lloyd, Andrew W\|Phillips, Gary J\|Macfarlane, Wendy M
PMID:	28542038

378.
Journal:	Int J Oncol. 2017 Jul;51(1):128-144.
Title:	Sorafenib induces variations of the DNA methylome in HA22T/VGH human hepatocellular carcinoma-derived cells.
Author:	Abeni, Edoardo\|Salvi, Alessandro\|Marchina, Eleonora\|Traversa, Michele\|Arici, Bruna\|De Petro, Giuseppina
PMID:	28560380

379.
Journal:	Oncol Rep. 2017 Jul;38(1):141-150.
Title:	Overexpression of microRNA-133b is associated with the increased survival of patients with hepatocellular carcinoma after curative hepatectomy: Involvement of the EGFR/PI3K/Akt/mTOR signaling pathway.
Author:	Wang, Xuedong\|Zeng, Jianping\|Wang, Liang\|Zhang, Xinjing\|Liu, Zhiqian\|Zhang, Hongyi\|Dong, Jiahong
PMID:	28586051

380.
Journal:	PLoS One. 2017 Jun 8;12(6):e0179202.
Title:	Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors.
Author:	Mahfouz, Nadine\|Tahtouh, Roula\|Alaaeddine, Nada\|El Hajj, Joelle\|Sarkis, Riad\|Hachem, Ray\|Raad, Issam\|Hilal, George
PMID:	28594907

381.
Journal:	Chem Biol Interact. 2017 Aug 1;273:99-106.
Title:	Oxidative stress plays a key role in butyrate-mediated autophagy via Akt/mTOR pathway in hepatoma cells.
Author:	Pant, Kishor\|Saraya, Anoop\|Venugopal, Senthil K
PMID:	28600122

382.
Journal:	Oncogenesis. 2017 Jun 12;6(6):e347.
Title:	TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway.
Author:	Yin, F\|Sharen, G\|Yuan, F\|Peng, Y\|Chen, R\|Zhou, X\|Wei, H\|Li, B\|Jing, W\|Zhao, J
PMID:	28604762

383.
Journal:	Oncotarget. 2017 Jul 18;8(29):47984-47997.
Title:	Co-targeting of IGF1R/mTOR pathway by miR-497 and miR-99a impairs hepatocellular carcinoma development.
Author:	Cheng, Henghui\|Xue, Jin\|Yang, Shouhua\|Chen, Yaobin\|Wang, Yu\|Zhu, Yuanli\|Wang, Xiaoyan\|Kuang, Dong\|Ruan, Qiurong\|Duan, Yaqi\|Wang, Guoping
PMID:	28624790

384.
Journal:	Int J Med Sci. 2017 Apr 9;14(6):523-529.
Title:	Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells.
Author:	Liu, Jianhua\|Liu, Yahui\|Meng, Lingyu\|Ji, Bai\|Yang, Daqing
PMID:	28638267

385.
Journal:	Int J Biol Sci. 2017 Jun 1;13(6):772-781.
Title:	Angiomotin Family Members: Oncogenes or Tumor Suppressors?
Author:	Lv, Meng\|Shen, Yanwei\|Yang, Jiao\|Li, Shuting\|Wang, Biyuan\|Chen, Zheling\|Li, Pan\|Liu, Peijun\|Yang, Jin
PMID:	28656002

386.
Journal:	Exp Cell Res. 2017 Sep 15;358(2):188-198.
Title:	LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway.
Author:	Shen, Yueming\|Liu, Yingying\|Sun, Ting\|Yang, Wei
PMID:	28689810

387.
Journal:	World J Gastroenterol. 2017 Jun 21;23(23):4311-4316.
Title:	Benefit of everolimus in treatment of an intrahepatic cholangiocarcinoma patient with a PIK3CA mutation.
Author:	Bian, Ji-Lai\|Wang, Mei-Mei\|Tong, En-Juan\|Sun, Jing\|Li, Ming\|Miao, Zhi-Bo\|Li, Yan-Lin\|Zhu, Bai-Hong\|Xu, Jia-Jia
PMID:	28694672

388.
Journal:	Eur J Cancer. 2017 Sep;83:56-70.
Title:	New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Author:	Golob-Schwarzl, Nicole\|Krassnig, Stefanie\|Toeglhofer, Anna M\|Park, Young Nyun\|Gogg-Kamerer, Margit\|Vierlinger, Klemens\|Schroder, Fabian\|Rhee, Hyungjn\|Schicho, Rudolf\|Fickert, Peter\|Haybaeck, Johannes
PMID:	28715695

389.
Journal:	Adv Exp Med Biol. 2017;959:49-64.
Title:	Molecular Pathogenesis of Liver Injury in Hereditary Tyrosinemia 1.
Author:	Tanguay, Robert M\|Angileri, Francesca\|Vogel, Arndt
PMID:	28755183

390.
Journal:	Sci Rep. 2017 Aug 9;7(1):7649.
Title:	Up-regulation of BRCA1-associated RING Domain 1 Promotes Hepatocellular Carcinoma Progression by Targeting Akt Signaling.
Author:	Liao, Yan\|Yuan, Shengguang\|Chen, Xinhuang\|Zhu, Pengpeng\|Li, Jun\|Qin, Liling\|Liao, Weijia
PMID:	28794477

391.
Journal:	Transl Oncol. 2017 Oct;10(5):793-799.
Title:	Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1(+/-) Mice.
Author:	Shen, Ming Hong\|Samsel, Paulina\|Shen, Louise L\|Narov, Kalin\|Yang, Jian\|Sampson, Julian R
PMID:	28844017

392.
Journal:	Oncol Rep. 2017 Oct;38(4):2173-2181.
Title:	MicroRNA-144-3p suppresses tumor growth and angiogenesis by targeting SGK3 in hepatocellular carcinoma.
Author:	Wu, Manya\|Huang, Chaoyuan\|Huang, Xinping\|Liang, Rong\|Feng, Yan\|Luo, Xiaoling
PMID:	28849156

393.
Journal:	Mol Cancer. 2017 Aug 30;16(1):149.
Title:	The biology of Hepatocellular carcinoma: implications for genomic and immune therapies.
Author:	Khemlina, Galina\|Ikeda, Sadakatsu\|Kurzrock, Razelle
PMID:	28854942

394.
Journal:	Am J Transl Res. 2017 Aug 15;9(8):3558-3572. eCollection 2017.
Title:	A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.
Author:	Zhu, Qiaohua\|Luo, Meihua\|Zhou, Chengyu\|Zhou, Zhiwei\|He, Zhixu\|Yu, Xinfa\|Zhou, Shufeng
PMID:	28861148

395.
Journal:	PLoS One. 2017 Sep 8;12(9):e0184213.
Title:	Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1alpha-dependent and -independent mechanism.
Author:	Wan, Xing\|Liu, Yuanyuan\|Zhao, Yuyan\|Sun, Xiaoqi\|Fan, Dongxiao\|Guo, Lei
PMID:	28886081

396.
Journal:	J Cancer Res Ther. 2017;13(4):725-729.
Title:	Effects of Macrothele raven venom on intrarenal invasion and metastasis of H22 liver cancer cells in mice.
Author:	Hou, Yi\|Zhao, Xiaokun\|Chen, Jiaqin\|Zhou, Jingsheng\|Chen, Weiwei\|Mao, Haifeng\|Chen, Rui
PMID:	28901322

397.
Journal:	Mol Med Rep. 2017 Nov;16(5):7064-7071.
Title:	mTOR inhibition reduces growth and adhesion of hepatocellular carcinoma cells in vitro.
Author:	Engl, Tobias\|Rutz, Jochen\|Maxeiner, Sebastian\|Juengel, Eva\|Roos, Frederik\|Khoder, Wael\|Bechstein, Wolf O\|Nelson, Karen\|Tsaur, Igor\|Haferkamp, Axel\|Blaheta, Roman A
PMID:	28901501

398.
Journal:	Int J Oncol. 2017 Oct;51(4):1291-1299.
Title:	Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo.
Author:	Liu, Xiaoni\|Xu, Jianji\|Wang, Shuang\|Yu, Xiaoxiao\|Kou, Boxin\|Chai, Mengyin\|Zang, Yunjin\|Chen, Dexi
PMID:	28902369

399.
Journal:	Oncotarget. 2017 Apr 18;8(34):57707-57722.
Title:	The role of autophagy in hepatocellular carcinoma: friend or foe.
Author:	Liu, Lian\|Liao, Jia-Zhi\|He, Xing-Xing\|Li, Pei-Yuan
PMID:	28915706

400.
Journal:	Mol Cancer Ther. 2017 Dec;16(12):2711-2723.
Title:	Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma.
Author:	Yu, Haiyang\|Qiu, Yuling\|Pang, Xu\|Li, Jian\|Wu, Song\|Yin, Shuangshuang\|Han, Lifeng\|Zhang, Yi\|Jin, Chengyun\|Gao, Xiumei\|Hu, Wenwei\|Wang, Tao
PMID:	28974556

401.
Journal:	Oncotarget. 2017 Aug 2;8(39):66154-66168.
Title:	EDG2 enhanced the progression of hepatocellular carcinoma by LPA/PI3K/AKT/ mTOR signaling.
Author:	Xu, Meng\|Liu, Zhikui\|Wang, Cong\|Yao, Bowen\|Zheng, Xin
PMID:	29029500

402.
Journal:	Sci Rep. 2017 Oct 16;7(1):13201.
Title:	Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas.
Author:	Lee, Hyun Min\|Joh, Jae Won\|Seo, Se-Ri\|Kim, Won-Tae\|Kim, Min Kyu\|Choi, Hong Seo\|Kim, So Young\|Jang, Young-Joo\|Sinn, Dong Hyun\|Choi, Gyu Seong\|Kim, Jong Man\|Kwon, Choon Hyuck David\|Chang, Hee Jin\|Kim, Dae Shick\|Ryu, Chun Jeih
PMID:	29038587

403.
Journal:	Exp Ther Med. 2017 Oct;14(4):3658-3664.
Title:	The long non-coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma.
Author:	Ye, Bailiang\|Hu, Bingren\|Zheng, Zhihai\|Zheng, Ru\|Shi, Yixiong
PMID:	29042961

404.
Journal:	Oncol Rep. 2017 Nov;38(5):2825-2835.
Title:	Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest.
Author:	Oura, Kyoko\|Tadokoro, Tomoko\|Fujihara, Shintaro\|Morishita, Asahiro\|Chiyo, Taiga\|Samukawa, Eri\|Yamana, Yoshimi\|Fujita, Koji\|Sakamoto, Teppei\|Nomura, Takako\|Yoneyama, Hirohito\|Kobara, Hideki\|Mori, Hirohito\|Iwama, Hisakazu\|Okano, Keiichi\|Suzuki, Yasuyuki\|Mas
PMID:	29048654

405.
Journal:	Oncotarget. 2017 May 11;8(42):71657-71671.
Title:	A novel synthetic derivative of quercetin, 8-trifluoromethyl-3,5,7,3',4'-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway.
Author:	Tao, Ting\|He, Caimei\|Deng, Jun\|Huang, Yanjun\|Su, Qiongli\|Peng, Mei\|Yi, Meiling\|Darko, Kwame Oteng\|Zou, Hui\|Yang, Xiaoping
PMID:	29069736

406.
Journal:	Gut. 2017 Oct 26. pii: gutjnl-2017-314208.
Title:	Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling.
Author:	Javary, Joaquim\|Allain-Courtois, Nathalie\|Saucisse, Nicolas\|Costet, Pierre\|Heraud, Capucine\|Benhamed, Fadila\|Pierre, Remi\|Bure, Corinne\|Pallares-Lupon, Nestor\|Do Cruzeiro, Marcio\|Postic, Catherine\|Cota, Daniela\|Dubus, Pierre\|Rosenbaum, Jean\|Benhamouche-Tr
PMID:	29074727

407.
Journal:	Molecules. 2017 Nov 11;22(11). pii: molecules22111934.
Title:	Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Author:	Song, Lihua\|Wang, Zhe\|Wang, Yurong\|Guo, Di\|Yang, Jianhong\|Chen, Lijuan\|Tan, Ninghua
PMID:	29137114

408.
Journal:	Oncotarget. 2017 Aug 1;8(51):88517-88528.
Title:	MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis.
Author:	de Conti, Aline\|Ortega, Juliana Festa\|Tryndyak, Volodymyr\|Dreval, Kostiantyn\|Moreno, Fernando Salvador\|Rusyn, Ivan\|Beland, Frederick A\|Pogribny, Igor P
PMID:	29179453

409.
Journal:	Oncotarget. 2017 Oct 4;8(54):92589-92603.
Title:	Elevation of MAP17 enhances the malignant behavior of cells via the Akt/mTOR pathway in hepatocellular carcinoma.
Author:	Chen, Xinhuang\|Liao, Yan\|Yu, Yaqun\|Zhu, Pengpeng\|Li, Jun\|Qin, Liling\|Liao, Weijia\|Huang, Zhaoquan
PMID:	29190940

410.
Journal:	Oncotarget. 2017 Sep 27;8(56):96171-96183.
Title:	Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling.
Author:	Zamani, Ali\|Fan, Huahao\|Luo, Guangxiang
PMID:	29221196

411.
Journal:	Cancer Cell. 2017 Dec 11;32(6):807-823.e12.
Title:	mTORC2 Promotes Tumorigenesis via Lipid Synthesis.
Author:	Guri, Yakir\|Colombi, Marco\|Dazert, Eva\|Hindupur, Sravanth K\|Roszik, Jason\|Moes, Suzette\|Jenoe, Paul\|Heim, Markus H\|Riezman, Isabelle\|Riezman, Howard\|Hall, Michael N
PMID:	29232555

412.
Journal:	J Endocr Soc. 2017 Mar 14;1(4):323-344.
Title:	Developmental Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether Induces Long-Lasting Changes in Liver Metabolism in Male Mice.
Author:	Khalil, Ahmed\|Parker, Mikhail\|Mpanga, Richard\|Cevik, Sebnem E\|Thorburn, Cassandra\|Suvorov, Alexander
PMID:	29264491

413.
Journal:	Oncotarget. 2017 Nov 30;8(66):110576-110591.
Title:	C21 steroid-enriched fraction refined from Marsdenia tenacissima inhibits hepatocellular carcinoma through the coordination of Hippo-Yap and PTEN-PI3K/AKT signaling pathways.
Author:	Zhang, Yu\|Li, Kaiqiang\|Ying, Youmin\|Chen, Bingyu\|Hao, Ke\|Chen, Boxu\|Zheng, Yu\|Lyu, Jianxin\|Tong, Xiangming\|Chen, Xiaopan\|Wang, Ying\|Zhan, Zhajun\|Zhang, Wei\|Wang, Zhen
PMID:	29299170

414.
Journal:	Oncotarget. 2017 Nov 24;8(65):109201-109216.
Title:	Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis.
Author:	Jennemann, Richard\|Federico, Giuseppina\|Mathow, Daniel\|Rabionet, Mariona\|Rampoldi, Francesca\|Popovic, Zoran V\|Volz, Martina\|Hielscher, Thomas\|Sandhoff, Roger\|Grone, Hermann-Josef
PMID:	29312601

415.
Journal:	Rom J Morphol Embryol. 2017;58(4):1257-1262.
Title:	The tyrosine kinase inhibitors effects on metastatic tumor graft in the chick chorioallantoic membrane assay.
Author:	Ciolofan, Alexandru\|Cretu, Octavian Marius\|Mogoanta, Stelian Stefanita\|Ciuca, Eduard Mihai
PMID:	29556614

416.
Journal:	Protein Cell. 2018 Mar;9(3):246-253.
Title:	RIG-I: a multifunctional protein beyond a pattern recognition receptor.
Author:	Xu, Xiao-Xiao\|Wan, Han\|Nie, Li\|Shao, Tong\|Xiang, Li-Xin\|Shao, Jian-Zhong
PMID:	28593618

417.
Journal:	Arch Toxicol. 2018 Jan;92(1):241-257.
Title:	Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells.
Author:	Kwon, Hee Young\|Kim, Ju-Ha\|Kim, Bonglee\|Srivastava, Sanjay K\|Kim, Sung-Hoon
PMID:	28676953

418.
Journal:	Mol Carcinog. 2018 Jan;57(1):44-56.
Title:	Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo.
Author:	Zhang, Hui-Hui\|Zhang, Ying\|Cheng, Yan-Na\|Gong, Fu-Lian\|Cao, Zhan-Qi\|Yu, Lu-Gang\|Guo, Xiu-Li
PMID:	28833603

419.
Journal:	Int J Hyperthermia. 2018 Sep;34(6):812-823.
Title:	Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma.
Author:	Thompson, Scott M\|Jondal, Danielle E\|Butters, Kim A\|Knudsen, Bruce E\|Anderson, Jill L\|Stokes, Matthew P\|Jia, Xiaoying\|Grande, Joseph P\|Roberts, Lewis R\|Callstrom, Matthew R\|Woodrum, David A
PMID:	28954551

420.
Journal:	Mol Carcinog. 2018 Feb;57(2):201-215.
Title:	Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through beta-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.
Author:	Zhang, Bin\|Deng, Chao\|Wang, Lei\|Zhou, Fan\|Zhang, Shu\|Kang, Wei\|Zhan, Ping\|Chen, Juan\|Shen, Shanshan\|Guo, Huimin\|Zhang, Ming\|Wang, Yi\|Zhang, Feng\|Zhang, Wei\|Xiao, Jiangqiang\|Kong, Bo\|Friess, Helmut\|Zhuge, Yuzheng\|Yan, Hongli\|Zou, Xiaoping
PMID:	29027712

421.
Journal:	Mol Cancer Ther. 2018 Jan;17(1):60-72.
Title:	Combinatorial Treatment with mTOR Inhibitors and Streptozotocin Leads to Synergistic In Vitro and In Vivo Antitumor Effects in Insulinoma Cells.
Author:	Bollard, Julien\|Patte, Celine\|Massoma, Patrick\|Goddard, Isabelle\|Gadot, Nicolas\|Benslama, Noura\|Hervieu, Valerie\|Ferraro-Peyret, Carole\|Cordier-Bussat, Martine\|Scoazec, Jean-Yves\|Roche, Colette\|Walter, Thomas\|Vercherat, Cecile
PMID:	29051320

422.
Journal:	Hepatology. 2018 Apr;67(4):1392-1407.
Title:	Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice.
Author:	Varshney, Aditi\|Panda, Jiban J\|Singh, Avishek K\|Yadav, Nitin\|Bihari, Chhagan\|Biswas, Subhrajit\|Sarin, Shiv K\|Chauhan, Virander S
PMID:	29108133

423.
Journal:	J Biochem Mol Toxicol. 2018 Jan;32(1).
Title:	Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation.
Author:	Tan, Jun\|Ye, Jingfen\|Song, Meijun\|Zhou, Mi\|Hu, Yaoren
PMID:	29112301

424.
Journal:	Int J Oncol. 2018 Jan;52(1):189-200.
Title:	Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins.
Author:	De Araujo, Raimundo F Jr\|Pessoa, Jonas B\|Cruz, Luis J\|Chan, Alan B\|De Castro Miguel, Emilio\|Cavalcante, Romulo S\|Brito, Gerly Anne C\|Silva, Heloiza Fernada O\|Gasparotto, Luiz H S\|Guedes, Paulo M M\|Araujo, Aurigena A
PMID:	29115423

425.
Journal:	Exp Cell Res. 2018 Jan 1;362(1):142-151.
Title:	BCA3 contributes to the malignant progression of hepatocellular carcinoma through AKT activation and NF-kappaB translocation.
Author:	Ma, Dong\|Li, Mengquan\|Su, Jing\|Zhang, Shuijun
PMID:	29133128

426.
Journal:	Mol Cancer Res. 2018 Feb;16(2):256-268.
Title:	Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis.
Author:	Wani, Nissar Ahmad\|Zhang, Bo\|Teng, Kun-Yu\|Barajas, Juan M\|Motiwala, Tasneem\|Hu, Peng\|Yu, Lianbo\|Bruschweiler, Rafael\|Ghoshal, Kalpana\|Jacob, Samson T
PMID:	29187559

427.
Journal:	Hepatology. 2018 Jun;67(6):2271-2286.
Title:	Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma.
Author:	Zhang, Hong\|Li, Xiao-Xing\|Yang, Yang\|Zhang, Yanjie\|Wang, Hui-Yun\|Zheng, X F Steven
PMID:	29220539

428.
Journal:	Acta Histochem. 2018 Feb;120(2):95-102.
Title:	MiR-199-3p replacement affects E-cadherin expression through Notch1 targeting in hepatocellular carcinoma.
Author:	Giovannini, Catia\|Fornari, Francesca\|Dallo, Rossella\|Gagliardi, Martina\|Nipoti, Elisa\|Vasuri, Francesco\|Coada, Camelia Alexandra\|Ravaioli, Matteo\|Bolondi, Luigi\|Gramantieri, Laura
PMID:	29249451

429.
Journal:	Oncol Rep. 2018 Feb;39(2):843-850.
Title:	Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib.
Author:	Yokoi, Kenta\|Kobayashi, Akira\|Motoyama, Hiroaki\|Kitazawa, Masato\|Shimizu, Akira\|Notake, Tsuyoshi\|Yokoyama, Takahide\|Matsumura, Tomio\|Takeoka, Michiko\|Miyagawa, Shin-Ichi
PMID:	29251327

430.
Journal:	Biochem Biophys Res Commun. 2018 Jan 22;495(4):2566-2572.
Title:	Knockdown of AMPKalpha decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.
Author:	Murata, Yasuhiko\|Hashimoto, Takuma\|Urushihara, Yusuke\|Shiga, Soichiro\|Takeda, Kazuya\|Jingu, Keiichi\|Hosoi, Yoshio
PMID:	29284117

431.
Journal:	Biochem Biophys Res Commun. 2018 Mar 11;497(3):916-923.
Title:	The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS.
Author:	Cui, Yong-Qiang\|Liu, Yan-Jun\|Zhang, Fan
PMID:	29288670

432.
Journal:	Exp Mol Med. 2018 Jan 5;50(1):e417.
Title:	Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway.
Author:	Xu, Zhong\|Hu, Junjie\|Cao, Hui\|Pilo, Maria G\|Cigliano, Antonio\|Shao, Zixuan\|Xu, Meng\|Ribback, Silvia\|Dombrowski, Frank\|Calvisi, Diego F\|Chen, Xin
PMID:	29303510

433.
Journal:	Cell Death Dis. 2018 Jan 5;9(1):4.
Title:	The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma.
Author:	Pollutri, Daniela\|Patrizi, Clarissa\|Marinelli, Sara\|Giovannini, Catia\|Trombetta, Elena\|Giannone, Ferdinando A\|Baldassarre, Maurizio\|Quarta, Santina\|Vandewynckel, Y P\|Vandierendonck, A\|Van Vlierberghe, H\|Porretti, Laura\|Negrini, Massimo\|Bolondi, Luigi\|Gram
PMID:	29305580

434.
Journal:	Mol Med Rep. 2018 Mar;17(3):4599-4604.
Title:	Vitexin induces G2/Mphase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells.
Author:	Zhang, Guangning\|Li, Dongyuan\|Chen, Hao\|Zhang, Junchen\|Jin, Xingyi
PMID:	29328424

435.
Journal:	Oncol Rep. 2018 Mar;39(3):1423-1431.
Title:	TTF1NP induces protective autophagy during apoptosis by inhibiting the Akt/mTOR pathway and activating JNK in human liver cancer cells.
Author:	Zhang, Xuan\|Zhang, Meilan\|Xiao, Bin\|Jiao, Wenjun\|Zhang, Silin\|Zhang, Xuewu
PMID:	29328481

436.
Journal:	Eur J Immunol. 2018 Apr;48(4):683-695.
Title:	Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model.
Author:	Dai, Kai\|Huang, Yabing\|Chen, Zubing\|Sun, Xiaomei\|Yang, Lihua\|Jiang, Yingan
PMID:	29331106

437.
Journal:	J Med Chem. 2018 Feb 22;61(4):1552-1575.
Title:	Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Author:	Chen, Dizhong\|Soh, Chang Kai\|Goh, Wei Huang\|Wang, Haishan
PMID:	29360358

438.
Journal:	Invest New Drugs. 2018 Oct;36(5):773-781.
Title:	SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy.
Author:	Koukourakis, Michael I\|Giatromanolaki, Alexandra\|Fylaktakidou, Konstantina\|Sivridis, Efthimios\|Zois, Christos E\|Kalamida, Dimitra\|Mitrakas, Achilleas\|Pouliliou, Stamatia\|Karagounis, Ilias V\|Simopoulos, Konstantinos\|Ferguson, David J P\|Harris, Adrian L
PMID:	29387992

439.
Journal:	World J Hepatol. 2018 Jan 27;10(1):155-165.
Title:	Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis.
Author:	Bhat, Venkat\|Srinathan, Sujitha\|Pasini, Elisa\|Angeli, Marc\|Chen, Emily\|Baciu, Cristina\|Bhat, Mamatha
PMID:	29399289

440.
Journal:	Cell Death Dis. 2018 Feb 14;9(2):230.
Title:	Glycogen synthase kinase-3beta inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma.
Author:	Zhang, Na\|Liu, Xiaojia\|Liu, Lu\|Deng, Zhesong\|Zeng, Qingxuan\|Pang, Weiqiang\|Liu, Yang\|Song, Danqing\|Deng, Hongbin
PMID:	29445085

441.
Journal:	Cancer Lett. 2018 May 1;421:82-93.
Title:	Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells.
Author:	Cai, Mengjiao\|Sun, Xiao\|Wang, Wenchao\|Lian, Zhusheng\|Wu, Ping\|Han, Suxia\|Chen, Huan\|Zhang, Pumin
PMID:	29458144

442.
Journal:	Biomed Pharmacother. 2018 May;101:115-122.
Title:	Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway.
Author:	Hua, Hui\|Zhu, Yu\|Song, Yu-He
PMID:	29477471

443.
Journal:	Oncotarget. 2018 Jan 3;9(9):8400-8414.
Title:	Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells.
Author:	Sauzay, Chloe\|Louandre, Christophe\|Bodeau, Sandra\|Anglade, Frederic\|Godin, Corinne\|Saidak, Zuzana\|Fontaine, Jean-Xavier\|Usureau, Cedric\|Martin, Nathalie\|Molinie, Roland\|Pascal, Julie\|Mesnard, Francois\|Pluquet, Olivier\|Galmiche, Antoine
PMID:	29492203

444.
Journal:	Phytomedicine. 2018 Feb 1;40:98-105.
Title:	Early LC3 lipidation induced by d-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells.
Author:	Berliocchi, Laura\|Chiappini, Carlotta\|Adornetto, Annagrazia\|Gentile, Debora\|Cerri, Silvia\|Russo, Rossella\|Bagetta, Giacinto\|Corasaniti, Maria Tiziana
PMID:	29496180

445.
Journal:	Life Sci. 2018 Apr 15;199:48-59.
Title:	Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways.
Author:	Rodenak-Kladniew, Boris\|Castro, Agustina\|Starkel, Peter\|De Saeger, Christine\|Garcia de Bravo, Margarita\|Crespo, Rosana
PMID:	29510199

446.
Journal:	Oncotarget. 2018 Jan 6;9(11):9925-9939.
Title:	Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice.
Author:	Yamada, Shoji\|Takashina, Yoko\|Watanabe, Mitsuhiro\|Nagamine, Ryogo\|Saito, Yoshimasa\|Kamada, Nobuhiko\|Saito, Hidetsugu
PMID:	29515780

447.
Journal:	Exp Ther Med. 2018 Apr;15(4):3650-3658.
Title:	Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
Author:	Wang, Ji\|Wang, Chunying\|Bu, Gaofeng
PMID:	29545895

448.
Journal:	Nature. 2018 Mar 29;555(7698):678-682.
Title:	The protein histidine phosphatase LHPP is a tumour suppressor.
Author:	Hindupur, Sravanth K\|Colombi, Marco\|Fuhs, Stephen R\|Matter, Matthias S\|Guri, Yakir\|Adam, Kevin\|Cornu, Marion\|Piscuoglio, Salvatore\|Ng, Charlotte K Y\|Betz, Charles\|Liko, Dritan\|Quagliata, Luca\|Moes, Suzette\|Jenoe, Paul\|Terracciano, Luigi M\|Heim, Markus H\|H
PMID:	29562234

449.
Journal:	Hepatology. 2018 Mar 23.
Title:	PRDM8 exhibits antitumor activities toward hepatocellular carcinoma by targeting NAP1L1.
Author:	Chen, Zhiqiang\|Gao, Wen\|Pu, Liyong\|Zhang, Long\|Han, Guoyong\|Zuo, Xueliang\|Zhang, Yao\|Li, Xiangcheng\|Shen, Hongbing\|Wu, Jindao\|Wang, Xuehao
PMID:	29572888

450.
Journal:	Arch Toxicol. 2018 Jun;92(6):2109-2118.
Title:	Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine.
Author:	Santos-Llamas, Ana\|Monte, Maria J\|Marin, Jose J G\|Perez, Maria J
PMID:	29594326

451.
Journal:	Int J Oncol. 2018 Jun;52(6):2051-2060.
Title:	Synergistic anti-hepatoma effect of bufalin combined with sorafenib via mediating the tumor vascular microenvironment by targeting mTOR/VEGF signaling.
Author:	Wang, Haiyong\|Zhang, Chenyue\|Chi, Huiying\|Meng, Zhiqiang
PMID:	29620259

452.
Journal:	Eur J Med Chem. 2018 May 10;151:237-247.
Title:	Phthalimide conjugations for the degradation of oncogenic PI3K.
Author:	Li, Wenlu\|Gao, Chunmei\|Zhao, Lei\|Yuan, Zigao\|Chen, Yuzong\|Jiang, Yuyang
PMID:	29625382

453.
Journal:	Oncoimmunology. 2018 Mar 6;7(4):e1404214.
Title:	OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis.
Author:	Xie, Kunlin\|Xu, Lin\|Wu, Hao\|Liao, Haotian\|Luo, Lin\|Liao, Mingheng\|Gong, Jianping\|Deng, Yang\|Yuan, Kefei\|Wu, Hong\|Zeng, Yong
PMID:	29632718

454.
Journal:	Sci Transl Med. 2018 Apr 18;10(437). pii: 10/437/eaap9840.
Title:	Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target.
Author:	Liu, Dabin\|Wong, Chi Chun\|Fu, Li\|Chen, Huarong\|Zhao, Liuyang\|Li, Chuangen\|Zhou, Yunfei\|Zhang, Yanquan\|Xu, Weiqi\|Yang, Yidong\|Wu, Bin\|Cheng, Gong\|Lai, Paul Bo-San\|Wong, Nathalie\|Sung, Joseph J Y\|Yu, Jun
PMID:	29669855

455.
Journal:	Onco Targets Ther. 2018 Apr 9;11:2017-2028.
Title:	Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity.
Author:	Yao, Chong\|Liu, Bing-Bing\|Qian, Xiao-Dong\|Li, Li-Qin\|Cao, Heng-Bin\|Guo, Qiao-Sheng\|Zhou, Gui-Fen
PMID:	29670377

456.
Journal:	Biomed Pharmacother. 2018 Jul;103:699-707.
Title:	Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells.
Author:	Yang, Jiali\|Pi, Cuicui\|Wang, Guanghui
PMID:	29680738

457.
Journal:	Clin Cancer Res. 2018 Aug 1;24(15):3767-3780.
Title:	Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.
Author:	Veiga, Sonia R\|Ge, Xuemei\|Mercer, Carol A\|Hernandez-Alvarez, Maria I\|Thomas, Hala Elnakat\|Hernandez-Losa, Javier\|Ramon Y Cajal, Santiago\|Zorzano, Antonio\|Thomas, George\|Kozma, Sara C
PMID:	29691292

458.
Journal:	Braz J Med Biol Res. 2018;51(6):e7080.
Title:	LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells.
Author:	Chen, Changxuan\|Wang, Kaizhen\|Wang, Qian\|Wang, Xin
PMID:	29694502

459.
Journal:	Biochem Cell Biol. 2018 Apr 30.
Title:	The phosphoinositide 3-kinase (PI3K) pathway and glycogen synthase kinase-3 (GSK-3) positively regulate the activity of metal-responsive transcription factor-1 (MTF-1) in response to zinc ions.
Author:	Andeol, Yannick\|Bonneau, Jessica\|M Gagne, Laurence\|Jacquet, Kevin\|Rivest, Veronique\|Huot, Marc-Etienne\|Seguin, Carl
PMID:	29707960

460.
Journal:	Biomed Pharmacother. 2018 Mar;99:921-930.
Title:	Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma.
Author:	Xia, Jufeng\|Rong, Ling\|Sawakami, Tatsuo\|Inagaki, Yoshinori\|Song, Peipei\|Hasegawa, Kiyoshi\|Sakamoto, Yoshihiro\|Tang, Wei
PMID:	29710492

461.
Journal:	Med Sci Monit. 2018 May 3;24:2735-2743.
Title:	Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC).
Author:	Zhang, Yu\|Jia, Qing-An\|Kadel, Dhruba\|Zhang, Xiao-Fei\|Zhang, Quan-Bao
PMID:	29720580

462.
Journal:	J Pharmacokinet Pharmacodyn. 2018 Aug;45(4):607-620.
Title:	Multiscale systems pharmacological analysis of everolimus action in hepatocellular carcinoma.
Author:	Ande, Anusha\|Chaar, Maher\|Ait-Oudhia, Sihem
PMID:	29725796

463.
Journal:	Hepatology. 2018 May 5.
Title:	Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition.
Author:	Wu, Raymond\|Murali, Ramachandran\|Kabe, Yasuaki\|French, Samuel W\|Chiang, Yi-Ming\|Liu, Siyu\|Sher, Linda\|Wang, Clay C\|Louie, Stan\|Tsukamoto, Hidekazu
PMID:	29729190

464.
Journal:	Cell Physiol Biochem. 2018;46(6):2261-2270.
Title:	MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma.
Author:	Han, Guoyong\|Zhang, Long\|Ni, Xuhao\|Chen, Zhiqiang\|Pan, Xiongxiong\|Zhu, Qin\|Li, Shu\|Wu, Jindao\|Huang, Xinli\|Wang, Xuehao
PMID:	29734164

465.
Journal:	Int J Mol Sci. 2018 May 19;19(5). pii: ijms19051518.
Title:	Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells.
Author:	Refolo, Maria Grazia\|Lippolis, Catia\|Carella, Nicola\|Cavallini, Aldo\|Messa, Caterina\|D'Alessandro, Rosalba
PMID:	29783729

466.
Journal:	Oncol Lett. 2018 Jun;15(6):9553-9558.
Title:	Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells.
Author:	Zhang, Yongqiang\|Jia, Jun\|Li, Ying\|Chen, Yan-Ge\|Huang, Huan\|Qiao, Yang\|Zhu, Yu
PMID:	29805677

467.
Journal:	Cell Death Dis. 2018 May 29;9(6):646.
Title:	CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma.
Author:	Lu, Shuai\|Yao, Yao\|Xu, Guolong\|Zhou, Chao\|Zhang, Yuan\|Sun, Jie\|Jiang, Runqiu\|Shao, Qing\|Chen, Yun
PMID:	29844385

468.
Journal:	Oncol Lett. 2018 Jun;15(6):9333-9338.
Title:	DNA damage regulated autophagy modulator 1 recovers the function of apoptosis-stimulating of p53 protein 2 on inducing apoptotic cell death in Huh7.5 cells.
Author:	Liu, Dongjie\|Li, Rui\|Guo, Xianghua\|Pang, Lijun\|Zang, Yunjin\|Liu, Kai\|Chen, Dexi
PMID:	29844830

469.
Journal:	Mol Ther Nucleic Acids. 2018 Jun 1;11:485-493.
Title:	miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model.
Author:	Callegari, Elisa\|D'Abundo, Lucilla\|Guerriero, Paola\|Simioni, Carolina\|Elamin, Bahaeldin K\|Russo, Marta\|Cani, Alice\|Bassi, Cristian\|Zagatti, Barbara\|Giacomelli, Luciano\|Blandamura, Stella\|Moshiri, Farzaneh\|Ultimo, Simona\|Frassoldati, Antonio\|Altavilla, Giu
PMID:	29858083

470.
Journal:	Biomed Pharmacother. 2018 Sep;105:326-333.
Title:	Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway.
Author:	Xing, Lichen\|Zhang, Leiming\|Feng, Yali\|Cui, Zhe\|Ding, Lin
PMID:	29864621

471.
Journal:	Mol Cancer. 2018 Jun 12;17(1):94.
Title:	Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a.
Author:	Xin, Xiaoru\|Wu, Mengying\|Meng, Qiuyu\|Wang, Chen\|Lu, Yanan\|Yang, Yuxin\|Li, Xiaonan\|Zheng, Qidi\|Pu, Hu\|Gui, Xin\|Li, Tianming\|Li, Jiao\|Jia, Song\|Lu, Dongdong
PMID:	29895332

472.
Journal:	Oncotarget. 2018 May 25;9(40):26032-26045.
Title:	CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128.
Author:	Badawi, Mohamed\|Kim, Jihye\|Dauki, Anees\|Sutaria, Dhruvitkumar\|Motiwala, Tasneem\|Reyes, Ryan\|Wani, Nissar\|Kolli, Shamalatha\|Jiang, Jinmai\|Coss, Christopher C\|Jacob, Samson T\|Phelps, Mitch A\|Schmittgen, Thomas D
PMID:	29899840

473.
Journal:	BMC Cancer. 2018 Jun 18;18(1):661.
Title:	Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma progression by activating mTOR signaling pathway.
Author:	Liu, Hongying\|Wang, Xieqi\|Feng, Bing\|Tang, Lipeng\|Li, Weiping\|Zheng, Xirun\|Liu, Ying\|Peng, Yan\|Zheng, Guangjuan\|He, Qinglian
PMID:	29914442

474.
Journal:	Acta Pharmacol Sin. 2018 Jun 19. pii: 10.1038/s41401-018-0047-1.
Title:	Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy.
Author:	Li, Bin\|Wu, Guo-Liang\|Dai, Wei\|Wang, Gang\|Su, Hao-Yuan\|Shen, Xue-Ping\|Zhan, Rui\|Xie, Jia-Ming\|Wang, Zhong\|Qin, Zheng-Hong\|Gao, Quan-Gen\|Shen, Gen-Hai
PMID:	29921885

475.
Journal:	J Steroid Biochem Mol Biol. 2018 Oct;183:159-166.
Title:	Combinatorial treatment of Rhizoma Paridis saponins and sorafenib overcomes the intolerance of sorafenib.
Author:	Yao, Jingwen\|Man, Shuli\|Dong, Honghong\|Yang, Li\|Ma, Long\|Gao, Wenyuan
PMID:	29932973

476.
Journal:	J Cancer. 2018 May 24;9(12):2061-2071.
Title:	A quantitative proteomic response of hepatocellular carcinoma Hep3B cells to danusertib, a pan-Aurora kinase inhibitor.
Author:	Zhu, Qiaohua\|Yu, Xinfa\|Zhou, Zhi-Wei\|Luo, Meihua\|Zhou, Chengyu\|He, Zhi-Xu\|Chen, Yong\|Zhou, Shu-Feng
PMID:	29937924

477.
Journal:	Adv Exp Med Biol. 2018;1061:55-62.
Title:	NAFLD Related-HCC: The Relationship with Metabolic Disorders.
Author:	Zhang, Xiang
PMID:	29956206

478.
Journal:	Phytother Res. 2018 Jul 4.
Title:	An ethyl acetate fraction of Artemisia capillaris (ACE-63) induced apoptosis and anti-angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma.
Author:	Jung, Kyung Hee\|Rumman, Marufa\|Yan, Honghua\|Cheon, Min Ji\|Choi, Jin Gyu\|Jin, Xing\|Park, Sunghouk\|Oh, Myung Sook\|Hong, Soon-Sun
PMID:	29972254

479.
Journal:	J Food Drug Anal. 2018 Jul;26(3):1024-1032.
Title:	Mulberry leaf extract inhibit hepatocellular carcinoma cell proliferation via depressing IL-6 and TNF-alpha derived from adipocyte.
Author:	Chang, Chun-Hua\|Chang, Yu-Tzu\|Tseng, Tsui-Hwa\|Wang, Chau-Jong
PMID:	29976395

480.
Journal:	Integr Cancer Ther. 2018 Jul 1:1534735418785999.
Title:	Antitumor Efficacy of Huqizhengxiao (HQZX) Decoction Based on Inhibition of Telomerase Activity in Nude Mice of Hepatocarcinoma Xenograft.
Author:	Yu, XiaoXiao\|Lin, Xue-Jun\|Wang, Shuang\|Liu, XiuHong\|Li, WeiHua\|Kou, Bu-Xin\|Chai, MengYin\|Chen, DeXi\|Liu, XiaoNi\|Wang, XiaoJun
PMID:	29978739

481.
Journal:	World J Gastroenterol. 2018 Jul 7;24(25):2647-2660.
Title:	Role of microRNAs in the main molecular pathways of hepatocellular carcinoma.
Author:	Vasuri, Francesco\|Visani, Michela\|Acquaviva, Giorgia\|Brand, Thomas\|Fiorentino, Michelangelo\|Pession, Annalisa\|Tallini, Giovanni\|D'Errico, Antonia\|de Biase, Dario
PMID:	29991871

482.
Journal:	Cancer Manag Res. 2018 Jul 2;10:1817-1826.
Title:	Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/beta-catenin signaling pathways.
Author:	Chen, Wei\|You, Jia\|Zheng, Qi\|Zhu, Yue-Yong
PMID:	29997441

483.
Journal:	J Cancer Prev. 2018 Jun;23(2):63-69.
Title:	Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells.
Author:	Hong, Ji-Young\|Park, So Hyun\|Park, Hyen Joo\|Lee, Sang Kook
PMID:	30003065

484.
Journal:	Oncol Rep. 2018 Sep;40(3):1657-1665.
Title:	Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.
Author:	Zhao, Hengli\|Jia, Huifeng\|Han, Qiuju\|Zhang, Jian
PMID:	30015890

485.
Journal:	Biomed Pharmacother. 2018 Sep;105:962-973.
Title:	Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma.
Author:	Ye, Ruifan\|Dai, Ninggao\|He, Qikuan\|Guo, Pengyi\|Xiang, Yukai\|Zhang, Qiong\|Hong, Zhong\|Zhang, Qiyu
PMID:	30021391

486.
Journal:	Sci Rep. 2018 Jul 19;8(1):10923.
Title:	Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells.
Author:	Wang, Jing\|Sun, Peng\|Chen, Yijun\|Yao, Hequan\|Wang, Shuzhen
PMID:	30026540

487.
Journal:	Int J Mol Sci. 2018 Jul 19;19(7). pii: ijms19072093.
Title:	Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth.
Author:	Bothwell, Paige J\|Kron, Clare D\|Wittke, Evan F\|Czerniak, Bradley N\|Bode, Barrie P
PMID:	30029480

488.
Journal:	Cancer Lett. 2018 Nov 1;436:139-148.
Title:	USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma.
Author:	Lu, Chang\|Ning, Zhen\|Wang, Aman\|Chen, Di\|Liu, Xiaolong\|Xia, Tian\|Tekcham, Dinesh Singh\|Wang, Wen\|Li, Tongming\|Liu, Xiumei\|Liu, Jing\|Qi, Huan\|Luo, Haifeng\|Du, Jian\|Ma, Chi\|Yan, Qiu\|Liu, Jiwei\|Xu, Guowang\|Piao, Hai-Long\|Tan, Guang
PMID:	30056112

489.
Journal:	PLoS One. 2018 Aug 1;13(8):e0200897.
Title:	NorUDCA promotes degradation of alpha1-antitrypsin mutant Z protein by inducing autophagy through AMPK/ULK1 pathway.
Author:	Tang, Youcai\|Blomenkamp, Keith S\|Fickert, Peter\|Trauner, Michael\|Teckman, Jeffrey H
PMID:	30067827

490.
Journal:	Biomed J. 2018 Jun;41(3):163-168.
Title:	Tumor microenvironment mediated by suppression of autophagic flux drives liver malignancy.
Author:	Chen, Kuang-Den\|Lin, Chih-Che\|Tsai, Ming-Chao\|Huang, Kuang-Tzu\|Chiu, King-Wah
PMID:	30080656

491.
Journal:	Oncotarget. 2018 Jul 20;9(56):30869-30882.
Title:	Applied diagnostics in liver cancer. Efficient combinations of sorafenib with targeted inhibitors blocking AKT/mTOR.
Author:	Llerena, Susana\|Garcia-Diaz, Nuria\|Curiel-Olmo, Soraya\|Agraz-Doblas, Antonio\|Garcia-Blanco, Agustin\|Pisonero, Helena\|Varela, Maria\|Santibanez, Miguel\|Almaraz, Carmen\|Cereceda, Laura\|Martinez, Nerea\|Arias-Loste, Maria Teresa\|Puente, Angela\|Martin-Ramos, Lu
PMID:	30112114

492.
Journal:	J Cell Physiol. 2018 Aug 21.
Title:	Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells.
Author:	Rodriguez-Hernandez, Maria A\|Gonzalez, Raul\|de la Rosa, Angel J\|Gallego, Paloma\|Ordonez, Raquel\|Navarro-Villaran, Elena\|Contreras, Laura\|Rodriguez-Arribas, Mario\|Gonzalez-Gallego, Javier\|Alamo-Martinez, Jose M\|Marin-Gomez, Luis M\|Del Campo, Jose A\|Quiles,
PMID:	30132846

493.
Journal:	Cancer Lett. 2018 Nov 28;437:56-66.
Title:	LncRNA CDKN2B-AS1 promotes tumor growth and metastasis of human hepatocellular carcinoma by targeting let-7c-5p/NAP1L1 axis.
Author:	Huang, Yuqi\|Xiang, Bo\|Liu, Yuanhua\|Wang, Yu\|Kan, Heping
PMID:	30165194

494.
Journal:	Sci Rep. 2018 Sep 3;8(1):13152.
Title:	A new meroterpenoid functions as an anti-tumor agent in hepatoma cells by downregulating mTOR activation and inhibiting EMT.
Author:	Wan, Haoqiang\|Li, Jiemei\|Zhang, Keda\|Zou, Xiaoting\|Ge, Lanlan\|Zhu, Fuqiang\|Zhou, Huirong\|Gong, Minna\|Wang, Tianwa\|Chen, Dongling\|Peng, Shusong\|Zhou, Boping\|Zeng, Xiaobin
PMID:	30177727

495.
Journal:	Liver Int. 2018 Sep 4.
Title:	P57-mediated autophagy promotes the efficacy of EGFR inhibitors in hepatocellular carcinoma.
Author:	Li, Wen-Yuan\|Li, Qing\|Jing, Li\|Wu, Tao\|Han, Li-Li\|Wang, Yu\|Yu, Si-Zhe\|Nan, Ke-Jun\|Guo, Hui
PMID:	30178471

496.
Journal:	Exp Ther Med. 2018 Oct;16(4):3041-3049.
Title:	Effect of autophagy-associated proteins on the arecoline-induced liver injury in mice.
Author:	Wang, Xia\|Song, Xinhong\|Si, Youjiao\|Xia, Jikai\|Wang, Bin\|Wang, Peiyuan
PMID:	30214523

497.
Journal:	Acta Pharmacol Sin. 2018 Sep 14. pii: 10.1038/s41401-018-0159-7.
Title:	Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway.
Author:	Han, Mei\|Gao, Hui\|Xie, Jing\|Yuan, Yin-Ping\|Yuan, Quan\|Gao, Ming-Quan\|Liu, Kai-Li\|Chen, Xue-Hong\|Han, Yan-Tao\|Han, Zhi-Wu
PMID:	30218072

498.
Journal:	Oncol Rep. 2018 Sep 21.
Title:	Upregulation of microRNA300 induces the proliferation of liver cancer by downregulating transcription factor FOXO1.
Author:	Chang, Yuanhong\|Zhou, Cancan\|Fan, Lin\|Qiu, Guanglin\|Wang, Guanghui\|Wei, Guangbing\|Chang, Xinming\|Li, Xuqi
PMID:	30272296

499.
Journal:	Oncol Rep. 2018 Oct 1.
Title:	Capsaicin and sorafenib combination treatment exerts synergistic antihepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling.
Author:	Dai, Ninggao\|Ye, Ruifan\|He, Qikuan\|Guo, Pengyi\|Chen, Hao\|Zhang, Qiyu
PMID:	30272354

500.
Journal:	Hepatology. 2018 Oct 3.
Title:	DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1.
Author:	Zhang, Hao\|Zhang, Yanqiu\|Zhu, Xiaoyun\|Chen, Chen\|Zhang, Chao\|Xia, Yuanzheng\|Zhao, Yucheng\|Andrisani, Ourania\|Kong, Lingyi
PMID:	30281815

501.
Journal:	Cell Death Dis. 2018 Oct 9;9(10):1027.
Title:	Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling.
Author:	Wang, Shanshan\|Zhu, Mingyue\|Wang, Qiaoyun\|Hou, Yuli\|Li, Lei\|Weng, Honglei\|Zhao, Yan\|Chen, Dexi\|Ding, Huiguo\|Guo, Junli\|Li, Mengsen
PMID:	30301886

502.
Journal:	Clin Exp Med. 2018 Oct 10. pii: 10.1007/s10238-018-0528-z.
Title:	mTOR and ERK regulate VKORC1 expression in both hepatoma cells and hepatocytes which influence blood coagulation.
Author:	Liu, Yaofu\|Li, Huiling\|Dong, Jianyi\|Ma, Lei\|Liao, Aijun\|Rong, Zhuona\|Zhou, Zhi\|Cao, Liang\|Wang, Fujin\|Wang, Jingyu\|Wang, Aiguo
PMID:	30306378

503.
Journal:	Cancer Manag Res. 2018 Sep 27;10:3985-3993.
Title:	Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation.
Author:	Yin, Yancun\|Zhou, Ling\|Zhan, Renhui\|Zhang, Qiang\|Li, Minjing
PMID:	30310320

504.
Journal:	Life Sci. 2018 Oct 9. pii: S0024-3205(18)30635-0.
Title:	Knockdown of FOXK1 suppresses liver cancer cell viability by inhibiting glycolysis.
Author:	Cui, Hong\|Gao, Qinqin\|Zhang, Ling\|Han, Feng\|Wang, Li
PMID:	30312701

505.
Journal:	Cell Death Differ. 2018 Oct 12. pii: 10.1038/s41418-018-0211-7.
Title:	Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation.
Author:	Li, Wenjiao\|Yue, Fei\|Dai, Yuan\|Shi, Boyun\|Xu, Guibin\|Jiang, Xianhan\|Zhou, Xinke\|Pfeifer, Gerd P\|Liu, Leyuan
PMID:	30315205

506.
Journal:	Clin Cancer Res. 2018 Oct 16. pii: 1078-0432.CCR-18-1833.
Title:	PTEN Expression, Not Mutation Status for TSC1, TSC2 or mTOR, Correlates With Outcome on Everolimus in Patients With Renal Cell Carcinoma Treated on RECORD-3.
Author:	Voss, Martin H\|Chen, David\|Reising, Albert\|Marker, Mahtab\|Shi, Jiayuan\|Xu, Jianing\|Ostrovnaya, Irina\|Seshan, Venkatraman\|Redzematovic, Almedina\|Chen, Ying-Bei\|Patel, Parul\|Han, Xia\|Hsieh, James J\|Hakimi, A Ari\|Motzer, Robert J
PMID:	30327302

507.
Journal:	J Cell Physiol. 2018 Oct 26.
Title:	Overexpression of cancer susceptibility candidate 2 inhibited progression of hepatocellular carcinoma cells.
Author:	Gao, Xiang\|Du, Haijun\|Zhang, Ruoxi\|Li, Cong\|Wang, Hongguang\|Xuan, Qi\|Liu, Diangang
PMID:	30362539

508.
Journal:	Nat Commun. 2018 Oct 26;9(1):4490.
Title:	Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling.
Author:	Liang, Jessie Qiaoyi\|Teoh, Narcissus\|Xu, Lixia\|Pok, Sharon\|Li, Xiangchun\|Chu, Eagle S H\|Chiu, Jonathan\|Dong, Ling\|Arfianti, Evi\|Haigh, W Geoffrey\|Yeh, Matthew M\|Ioannou, George N\|Sung, Joseph J Y\|Farrell, Geoffrey\|Yu, Jun
PMID:	30367044

509.
Journal:	Clin Cancer Res. 2018 Oct 29. pii: 1078-0432.CCR-18-2293.
Title:	Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies.
Author:	Harding, James J\|Nandakumar, Subhiksha\|Armenia, Joshua\|Khalil, Danny N\|Albano, Melanie\|Ly, Michele\|Shia, Jinru\|Hechtman, Jaclyn F\|Kundra, Ritika\|El Dika, Imane\|Do, Richard K\|Sun, Yichao\|Kingham, T Peter\|D'Angelica, Michael I\|Berger, Michael F\|Hyman, David
PMID:	30373752

510.
Journal:	Sci Rep. 2018 Oct 29;8(1):15950.
Title:	Molecular and Metabolic Markers of Fructose Induced Hepatic Insulin Resistance in Developing and Adult Rats are Distinct and Aegle marmelos is an Effective Modulator.
Author:	Nair, Jayachandran\|Velpandian, Thirumurthy\|Das, Ujjalkumar Subhash\|Sharma, Prateek\|Nag, Tapas\|Mathur, Sandeep R\|Mathur, Rajani
PMID:	30374065