Primary Site >> Liver Cancer
Gene >> MTOR
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Ref: mTOR and P70 S6 kinase expression in primary liver neoplasms. PMID: 15623621 |
Ref: Hepatocellular carcinoma: molecular pathways and new therapeutic targets. PMID: 15918149 Ref: Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. PMID: 16139919 |
Ref: Emerging drugs for hepatocellular carcinoma. PMID: 16939386 Ref: Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis. PMID: 17013836 |
Ref: Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. PMID: 17321636 Ref: MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells. PMID: 17427199 Ref: [Cell biology and genetics in liver cancer]. PMID: 17662221 Ref: Exploiting novel molecular targets in gastrointestinal cancers. PMID: 17990350 Ref: Molecular pathways and related target therapies in liver carcinoma. PMID: 18045179 Ref: From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now. PMID: 18087180 |
Ref: Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells. PMID: 17721885 Ref: Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells. PMID: 18075305 Ref: Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma. PMID: 18486258 Ref: Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma. PMID: 18723493 Ref: Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma. PMID: 18813808 Ref: Pivotal role of mTOR signaling in hepatocellular carcinoma. PMID: 18929564 Ref: ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft. PMID: 18930332 |
Ref: The role of mTOR inhibitors in the management of posttransplant malignancy. PMID: 19155967 Ref: mTOR inhibitors for hepatocellular cancer: a forward-moving target. PMID: 19192962 Ref: Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. PMID: 19220580 Ref: [Targeted therapies and their indications in solid neoplasias]. PMID: 19299048 Ref: Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells. PMID: 19343784 Ref: Identification of potential driver genes in human liver carcinoma by genomewide screening. PMID: 19366792 Ref: Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN. PMID: 19398230 Ref: Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. PMID: 19447220 Ref: Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis. PMID: 19475690 Ref: Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival. PMID: 19584164 Ref: Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. PMID: 19665249 Ref: Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines. PMID: 19816606 Ref: Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy. PMID: 19860903 Ref: Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway. PMID: 19865701 |
Ref: AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC). PMID: 19910069 Ref: Involvement of mTOR and survivin inhibition in tamoxifen-induced apoptosis in human hepatoblastoma cell line HepG2. PMID: 19931998 Ref: miR-221 overexpression contributes to liver tumorigenesis. PMID: 20018759 Ref: Molecular and functional genetics of hepatocellular carcinoma. PMID: 20036934 Ref: Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis. PMID: 20041408 Ref: Targeted therapy of hepatocellular cancer. PMID: 20074016 Ref: AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma. PMID: 20101735 Ref: Molecular genetics of hepatocellular neoplasia. PMID: 20182587 Ref: EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway. PMID: 20335389 Ref: Personalized molecular targeted therapy in advanced, recurrent hepatocellular carcinoma after liver transplantation: a proof of principle. PMID: 20347502 Ref: Molecularly targeted therapy in hepatocellular carcinoma. PMID: 20371362 Ref: Cancer gene discovery in hepatocellular carcinoma. PMID: 20385424 Ref: Pilot study: rapamycin in advanced hepatocellular carcinoma. PMID: 20629977 Ref: The role of signaling pathways in the development and treatment of hepatocellular carcinoma. PMID: 20639898 Ref: DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism. PMID: 20657652 Ref: Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. PMID: 20830746 Ref: [New possibilities of targeted therapy in the treatment of hepatocellular carcinoma with the help of molecular biology]. PMID: 20940115 Ref: Significance of p27 as potential biomarker for intracellular oxidative status. PMID: 21103079 Ref: PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. PMID: 21187475 Ref: [Down-regulation of mTOR activity and survivin expression during tamoxifen-induced apoptosis in hepatoblastoma cells]. PMID: 21223797 |
Ref: Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1alpha expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells. PMID: 20524035 Ref: NPC-16, a novel naphthalimide-polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells. PMID: 20809291 Ref: beta-hydroxy-beta-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. PMID: 21184031 Ref: Oleate-mediated activation of phospholipase D and mammalian target of rapamycin (mTOR) regulates proliferation and rapamycin sensitivity of hepatocarcinoma cells. PMID: 21240477 Ref: Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma. PMID: 21272562 Ref: Molecular pathogenesis of hepatocellular carcinoma. PMID: 21303380 Ref: Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. PMID: 21622715 Ref: Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. PMID: 21703185 Ref: Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. PMID: 21814046 Ref: Molecular targeted therapy for hepatocellular carcinoma: bench to bedside. PMID: 21829017 Ref: mTOR inhibitor for the treatment of hepatocellular carcinoma. PMID: 21829022 Ref: L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of beta-catenin-mutated human hepatocellular carcinoma cells. PMID: 21834755 Ref: The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. PMID: 21876130 Ref: HNF1alpha inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines. PMID: 21975049 Ref: Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. PMID: 21992728 Ref: Current treatment options for neuroendocrine tumors. PMID: 22076492 Ref: [Role of autophagy in the pathogenesis of liver diseases]. PMID: 22106162 |
Ref: Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo. PMID: 21835141 Ref: An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. PMID: 21903676 Ref: AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, PMID: 21993994 Ref: HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway. PMID: 22182943 Ref: Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation. PMID: 22184107 Ref: Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival. PMID: 22222116 Ref: PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation. PMID: 22261591 Ref: V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis. PMID: 22271091 Ref: 3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway. PMID: 22395446 Ref: Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. PMID: 22457330 Ref: Phase II study of sirolimus in treatment-naive patients with advanced hepatocellular carcinoma. PMID: 22459565 Ref: The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat. PMID: 22525806 Ref: Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model. PMID: 22559167 Ref: Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. PMID: 22560876 Ref: The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. PMID: 22562464 Ref: [Association of genetic polymorphisms of key molecules in JAK/STAT signaling pathway with susceptibility of hepatocellular carcinoma]. PMID: 22575147 Ref: Branched-chain amino acid deficiency stabilizes insulin-induced vascular endothelial growth factor mRNA in hepatocellular carcinoma cells. PMID: 22581719 Ref: Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFbeta tumor suppressor signaling pathways. PMID: 22622027 Ref: Hepatocellular carcinoma: important biomarkers and their significance in molecular diagnostics and therapy. PMID: 22680921 Ref: Metformin impairs the growth of liver kinase B1-intact cervical cancer cells. PMID: 22735790 Ref: The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment. PMID: 22753710 Ref: Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells. PMID: 22858649 Ref: Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. PMID: 22860996 Ref: mTor as a potential target for the prevention and treatment of hepatocellular carcinoma. PMID: 22873368 Ref: Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. PMID: 22898879 Ref: SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway. PMID: 22909393 Ref: Sorafenib inhibits hypoxia-inducible factor-1alpha synthesis: implications for antiangiogenic activity in hepatocellular carcinoma. PMID: 22929805 Ref: MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. PMID: 22940133 Ref: Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. PMID: 22965024 Ref: Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway. PMID: 22994747 Ref: microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma. PMID: 23023935 Ref: MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R. PMID: 23056576 Ref: The Predictive and Prognostic Significance of c-erb-B2, EGFR, PTEN, mTOR, PI3K, p27, and ERCC1 Expression in Hepatocellular Carcinoma. PMID: 23162604 Ref: Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells. PMID: 23167739 Ref: Pathways and targets in hepatocellular carcinoma. PMID: 23176622 Ref: Emerging signaling pathways in hepatocellular carcinoma. PMID: 24159576 |
Ref: Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. PMID: 22859060 Ref: Suppression of tumor proliferation and angiogenesis of hepatocellular carcinoma by HS-104, a novel phosphoinositide 3-kinase inhibitor. PMID: 22902995 Ref: HBx induces HepG-2 cells autophagy through PI3K/Akt-mTOR pathway. PMID: 23001846 Ref: Targeting tyrosine kinase receptors in hepatocellular carcinoma. PMID: 23016985 Ref: Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro. PMID: 23032518 Ref: Epigenetic deregulation of microRNAs: new opportunities to target oncogenic signaling pathways in hepatocellular carcinoma. PMID: 23092339 Ref: IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma. PMID: 23142281 Ref: Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling. PMID: 23164509 Ref: Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. PMID: 23321675 Ref: Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 beta mediate ursolic acid induced apoptosis in HepG2 liver cancer cells. PMID: 23325562 Ref: Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors. PMID: 23328074 Ref: Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy. PMID: 23344047 Ref: Molecular and metabolic changes in human liver clear cell foci resemble the alterations occurring in rat hepatocarcinogenesis. PMID: 23348238 Ref: The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. PMID: 23392177 Ref: The mTOR pathway in hepatic malignancies. PMID: 23408390 Ref: Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib. PMID: 23479136 Ref: Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma. PMID: 23489999 Ref: Comparative efficacy of sorafenib versus best supportive care in recurrent hepatocellular carcinoma after liver transplantation: a case-control study. PMID: 23500153 Ref: The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells. PMID: 23537100 Ref: Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. PMID: 23587162 Ref: Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor. PMID: 23604199 Ref: PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells. PMID: 23639247 Ref: Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis. PMID: 23684542 Ref: Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells. PMID: 23721490 Ref: The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (alpha4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A. PMID: 23740247 Ref: Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: implications for the treatment of human liver cancer. PMID: 23759595 Ref: PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation. PMID: 23769634 Ref: Actionable gene expression-based patient stratification for molecular targeted therapy in hepatocellular carcinoma. PMID: 23785399 Ref: Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. PMID: 23804702 Ref: The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives. PMID: 23845075 Ref: Prognostic impact of pERK in advanced hepatocellular carcinoma patients treated with sorafenib. PMID: 23845703 Ref: Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression. PMID: 23863156 Ref: A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma. PMID: 23906794 Ref: Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells. PMID: 23921128 Ref: Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells. PMID: 23922888 Ref: Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. PMID: 23958494 Ref: Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. PMID: 23962559 Ref: SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice. PMID: 24069385 Ref: Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein. PMID: 24223226 Ref: Blocking autophagic flux enhances matrine-induced apoptosis in human hepatoma cells. PMID: 24287900 Ref: Branched chain amino acid suppresses hepatocellular cancer stem cells through the activation of mammalian target of rapamycin. PMID: 24312415 Ref: Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression. PMID: 24376606 Ref: Clinical trials in hepatocellular carcinoma: an update. PMID: 24400222 |
Ref: AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. PMID: 24100703 Ref: EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma. PMID: 24285179 Ref: Segregation of signaling proteins as prognostic predictors for local recurrence and distant metastasis in hepatocellular carcinoma. PMID: 24297625 Ref: Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends. PMID: 24308993 Ref: Combination of cetuximab and rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma. PMID: 24325131 Ref: FoxO proteins: regulation and molecular targets in liver cancer. PMID: 24372208 Ref: Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression. PMID: 24378923 Ref: Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin. PMID: 24387108 Ref: Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. PMID: 24401568 Ref: HDAC2 provides a critical support to malignant progression of hepatocellular carcinoma through feedback control of mTORC1 and AKT. PMID: 24448241 Ref: Role for putative hepatocellular carcinoma stem cell subpopulations in biological response to incomplete thermal ablation: in vitro and in vivo pilot study. PMID: 24452318 Ref: eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1. PMID: 24466059 Ref: Prostaglandin E(2) receptor EP2 mediates Snail expression in hepatocellular carcinoma cells. PMID: 24626807 Ref: Angiosarcoma successfully treated with liver transplantation and sirolimus. PMID: 24641525 Ref: Inhibition of Akt reverses the acquired resistance to sorafenib by switching protective autophagy to autophagic cell death in hepatocellular carcinoma. PMID: 24705351 Ref: A proteomic view to characterize the effect of chitosan nanoparticle to hepatic cells: is chitosan nanoparticle an enhancer of PI3K/AKT1/mTOR pathway? PMID: 24757677 Ref: Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis. PMID: 24767856 Ref: CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. PMID: 24793486 Ref: Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions. PMID: 24799992 Ref: Rapamycin enhances cetuximab cytotoxicity by inhibiting mTOR-mediated drug resistance in mesenchymal hepatoma cells. PMID: 24800850 Ref: The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. PMID: 24837142 Ref: beta-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastoma. PMID: 24848510 Ref: Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma. PMID: 24853422 Ref: Celastrol inhibits the HIF-1alpha pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells. PMID: 24859482 Ref: Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. PMID: 24931142 Ref: Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway. PMID: 24960055 Ref: FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. PMID: 24970808 Ref: Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma. PMID: 25004403 Ref: The RNA expression signature of the HepG2 cell line as determined by the integrated analysis of miRNA and mRNA expression profiles. PMID: 25014136 Ref: MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R. PMID: 25026290 Ref: Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts. PMID: 25051375 Ref: Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer. PMID: 25063062 Ref: Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. PMID: 25072259 Ref: Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. PMID: 25082895 Ref: CIP2A regulates cell proliferation via the AKT signaling pathway in human lung cancer. PMID: 25109354 Ref: Cationic poly(amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular carcinoma cells. PMID: 25140534 Ref: 11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways. PMID: 25222667 Ref: Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression. PMID: 25229655 Ref: Integration of genomic information in the clinical management of HCC. PMID: 25260311 Ref: Advances in the study of molecularly targeted agents to treat hepatocellular carcinoma. PMID: 25262594 Ref: The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis. PMID: 25316153 Ref: Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib. PMID: 25327881 Ref: Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. PMID: 25362482 Ref: Molecular profiling of liver tumors: classification and clinical translation for decision making. PMID: 25369299 Ref: [EEF1A2 inhibits the p53 function in hepatocellular carcinoma via PI3K/AKT/mTOR-dependent stabilization of MDM4]. PMID: 25394965 Ref: Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma via targeting AKT-mTOR pathway. PMID: 25424347 Ref: Mammalian target of rapamycin inhibition in hepatocellular carcinoma. PMID: 25429315 Ref: U12, a UDCA derivative, acts as an anti-hepatoma drug lead and inhibits the mTOR/S6K1 and cyclin/CDK complex pathways. PMID: 25486097 |
Ref: Increased autophagy sustains the survival and pro-tumourigenic effects of neutrophils in human hepatocellular carcinoma. PMID: 25152203 Ref: Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. PMID: 25178877 Ref: The collagen triple helix repeat containing 1 facilitates hepatitis B virus-associated hepatocellular carcinoma progression by regulating multiple cellular factors and signal cascades. PMID: 25263696 Ref: Influence of Rictor and Raptor Expression of mTOR Signaling on Long-Term Outcomes of Patients with Hepatocellular Carcinoma. PMID: 25371154 Ref: Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. PMID: 25416439 Ref: mTOR and PDGF pathway blockade inhibits liver metastasis of colorectal cancer by modulating the tumor microenvironment. PMID: 25478811 Ref: 4-Acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production. PMID: 25494404 Ref: RNA over-editing of BLCAP contributes to hepatocarcinogenesis identified by whole-genome and transcriptome sequencing. PMID: 25499081 Ref: Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis. PMID: 25535034 Ref: SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice. PMID: 25537506 Ref: Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. PMID: 25592318 Ref: MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3. PMID: 25608840 Ref: Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis. PMID: 25623824 Ref: Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma. PMID: 25628925 Ref: Novel molecular targets for diagnosis and treatment of hepatocellular carcinoma. PMID: 25636956 Ref: Oncogenic KRAS promotes malignant brain tumors in zebrafish. PMID: 25644510 Ref: CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling. PMID: 25649767 Ref: FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells. PMID: 25656579 Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus. PMID: 25724664 Ref: Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1alpha to promote the metastasis of hepatocellular carcinoma. PMID: 25745995 Ref: Effects of fucoidan on proliferation, AMP-activated protein kinase, and downstream metabolism- and cell cycle-associated molecules in poorly differentiated human hepatoma HLF cells. PMID: 25776104 Ref: Sorafenib inhibits liver cancer growth by decreasing mTOR, AKT, and PI3K expression. PMID: 25778319 Ref: Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression. PMID: 25789991 Ref: Alpha-fetoprotein activates AKT/mTOR signaling to promote CXCR4 expression and migration of hepatoma cells. PMID: 25815363 Ref: AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells. PMID: 25817233 Ref: Telomerase inhibition decreases alpha-fetoprotein expression and secretion by hepatocellular carcinoma cell lines: in vitro and in vivo study. PMID: 25822740 Ref: DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells. PMID: 25843797 Ref: Integrated Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Quantitative Proteomic Analysis Identifies Galectin-1 as a Potential Biomarker for Predicting Sorafenib Resistance i PMID: 25850433 Ref: PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. PMID: 25865556 Ref: Arctigenin, a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3-K/Akt Signaling. PMID: 25920004 Ref: Tetrahydro Iso-Alpha Acids and Hexahydro Iso-Alpha Acids from Hops Inhibit Proliferation of Human Hepatocarcinoma Cell Lines and Reduce Diethylnitrosamine Induced Liver Tumor Formation in Rats. PMID: 25941903 Ref: Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response. PMID: 25962426 Ref: SC-III3, a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. PMID: 25964188 Ref: Galpha12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4alpha inactivation, which causes c-Met induction. PMID: 25965999 Ref: mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice. PMID: 25980751 Ref: The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells. PMID: 26003166 Ref: Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines. PMID: 26010766 Ref: Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells. PMID: 26026051 Ref: GC-MS Based Plasma Metabolomics for Identification of Candidate Biomarkers for Hepatocellular Carcinoma in Egyptian Cohort. PMID: 26030804 Ref: Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. PMID: 26055238 Ref: Co-expression of CXCL8 and HIF-1alpha is associated with metastasis and poor prognosis in hepatocellular carcinoma. PMID: 26078356 Ref: Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs. PMID: 26133123 Ref: Molecular Targeted Therapy for Hepatocellular Carcinoma: Present Status and Future Directions. PMID: 26133708 Ref: Antiproliferative effect of the methanol extract from the roots of Petasites japonicus on Hep3B hepatocellular carcinoma cells in vitro and in vivo. PMID: 26136894 Ref: Hepatocellular carcinoma: Where there is unmet need. PMID: 26160430 Ref: Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials. PMID: 26164085 Ref: Effects of Ras homolog gene family, member C gene silencing combined with rapamycin on hepatocellular carcinoma cell growth. PMID: 26165487 Ref: Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. PMID: 26225745 Ref: The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth. PMID: 26239364 Ref: MiR-132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3. PMID: 26252738 Ref: miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR. PMID: 26259252 Ref: Autophagy inhibition sensitizes KU-0063794-mediated anti-HepG2 hepatocellular carcinoma cell activity in vitro and in vivo. PMID: 26278819 Ref: CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARalpha pathways. PMID: 26282231 Ref: ARID2, p110alpha, p53, and beta-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications. PMID: 26284269 Ref: Epithelial to mesenchymal transition in the liver field: the double face of Everolimus in vitro. PMID: 26369804 Ref: A preclinical study on the combination therapy of everolimus and transarterial chemoembolization in hepatocellular carcinoma. PMID: 26396913 Ref: TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. PMID: 26418879 Ref: Blocking autophagy enhances meloxicam lethality to hepatocellular carcinoma by promotion of endoplasmic reticulum stress. PMID: 26481188 Ref: [Molecular and metabolic changes in human clear cell liver foci]. 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PMID: 28902369 Ref: The role of autophagy in hepatocellular carcinoma: friend or foe. PMID: 28915706 Ref: Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma. PMID: 28974556 Ref: EDG2 enhanced the progression of hepatocellular carcinoma by LPA/PI3K/AKT/ mTOR signaling. PMID: 29029500 Ref: Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas. PMID: 29038587 Ref: The long non-coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma. PMID: 29042961 Ref: Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest. PMID: 29048654 Ref: A novel synthetic derivative of quercetin, 8-trifluoromethyl-3,5,7,3',4'-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway. PMID: 29069736 Ref: Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling. PMID: 29074727 Ref: Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells. PMID: 29137114 Ref: MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis. PMID: 29179453 Ref: Elevation of MAP17 enhances the malignant behavior of cells via the Akt/mTOR pathway in hepatocellular carcinoma. PMID: 29190940 Ref: Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling. PMID: 29221196 Ref: mTORC2 Promotes Tumorigenesis via Lipid Synthesis. PMID: 29232555 Ref: Developmental Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether Induces Long-Lasting Changes in Liver Metabolism in Male Mice. PMID: 29264491 Ref: C21 steroid-enriched fraction refined from Marsdenia tenacissima inhibits hepatocellular carcinoma through the coordination of Hippo-Yap and PTEN-PI3K/AKT signaling pathways. PMID: 29299170 Ref: Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis. PMID: 29312601 Ref: The tyrosine kinase inhibitors effects on metastatic tumor graft in the chick chorioallantoic membrane assay. PMID: 29556614 |
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PMID: 29051320 Ref: Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice. PMID: 29108133 Ref: Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. PMID: 29112301 Ref: Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins. PMID: 29115423 Ref: BCA3 contributes to the malignant progression of hepatocellular carcinoma through AKT activation and NF-kappaB translocation. PMID: 29133128 Ref: Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis. PMID: 29187559 Ref: Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma. PMID: 29220539 Ref: MiR-199-3p replacement affects E-cadherin expression through Notch1 targeting in hepatocellular carcinoma. PMID: 29249451 Ref: Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib. PMID: 29251327 Ref: Knockdown of AMPKalpha decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217. PMID: 29284117 Ref: The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS. PMID: 29288670 Ref: Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway. PMID: 29303510 Ref: The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma. 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PMID: 29399289 Ref: Glycogen synthase kinase-3beta inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma. PMID: 29445085 Ref: Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells. PMID: 29458144 Ref: Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway. PMID: 29477471 Ref: Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells. PMID: 29492203 Ref: Early LC3 lipidation induced by d-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells. PMID: 29496180 Ref: Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways. PMID: 29510199 Ref: Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice. PMID: 29515780 Ref: Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway. PMID: 29545895 Ref: The protein histidine phosphatase LHPP is a tumour suppressor. PMID: 29562234 Ref: PRDM8 exhibits antitumor activities toward hepatocellular carcinoma by targeting NAP1L1. PMID: 29572888 Ref: Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine. PMID: 29594326 Ref: Synergistic anti-hepatoma effect of bufalin combined with sorafenib via mediating the tumor vascular microenvironment by targeting mTOR/VEGF signaling. PMID: 29620259 Ref: Phthalimide conjugations for the degradation of oncogenic PI3K. PMID: 29625382 Ref: OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis. PMID: 29632718 Ref: Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. PMID: 29669855 Ref: Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity. PMID: 29670377 Ref: Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. PMID: 29680738 Ref: Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR. PMID: 29691292 Ref: LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells. PMID: 29694502 Ref: The phosphoinositide 3-kinase (PI3K) pathway and glycogen synthase kinase-3 (GSK-3) positively regulate the activity of metal-responsive transcription factor-1 (MTF-1) in response to zinc ions. PMID: 29707960 Ref: Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma. PMID: 29710492 Ref: Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC). PMID: 29720580 Ref: Multiscale systems pharmacological analysis of everolimus action in hepatocellular carcinoma. PMID: 29725796 Ref: Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition. PMID: 29729190 Ref: MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma. PMID: 29734164 Ref: Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells. PMID: 29783729 Ref: Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells. PMID: 29805677 Ref: CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma. PMID: 29844385 Ref: DNA damage regulated autophagy modulator 1 recovers the function of apoptosis-stimulating of p53 protein 2 on inducing apoptotic cell death in Huh7.5 cells. PMID: 29844830 Ref: miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model. PMID: 29858083 Ref: Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway. PMID: 29864621 Ref: Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a. PMID: 29895332 Ref: CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128. PMID: 29899840 Ref: Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma progression by activating mTOR signaling pathway. PMID: 29914442 Ref: Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy. PMID: 29921885 Ref: Combinatorial treatment of Rhizoma Paridis saponins and sorafenib overcomes the intolerance of sorafenib. PMID: 29932973 Ref: A quantitative proteomic response of hepatocellular carcinoma Hep3B cells to danusertib, a pan-Aurora kinase inhibitor. PMID: 29937924 Ref: NAFLD Related-HCC: The Relationship with Metabolic Disorders. PMID: 29956206 Ref: An ethyl acetate fraction of Artemisia capillaris (ACE-63) induced apoptosis and anti-angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma. PMID: 29972254 Ref: Mulberry leaf extract inhibit hepatocellular carcinoma cell proliferation via depressing IL-6 and TNF-alpha derived from adipocyte. PMID: 29976395 Ref: Antitumor Efficacy of Huqizhengxiao (HQZX) Decoction Based on Inhibition of Telomerase Activity in Nude Mice of Hepatocarcinoma Xenograft. PMID: 29978739 Ref: Role of microRNAs in the main molecular pathways of hepatocellular carcinoma. PMID: 29991871 Ref: Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/beta-catenin signaling pathways. PMID: 29997441 Ref: Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells. PMID: 30003065 Ref: Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape. 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PMID: 30312701 Ref: Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation. PMID: 30315205 Ref: PTEN Expression, Not Mutation Status for TSC1, TSC2 or mTOR, Correlates With Outcome on Everolimus in Patients With Renal Cell Carcinoma Treated on RECORD-3. PMID: 30327302 Ref: Overexpression of cancer susceptibility candidate 2 inhibited progression of hepatocellular carcinoma cells. PMID: 30362539 Ref: Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling. PMID: 30367044 Ref: Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies. PMID: 30373752 Ref: Molecular and Metabolic Markers of Fructose Induced Hepatic Insulin Resistance in Developing and Adult Rats are Distinct and Aegle marmelos is an Effective Modulator. PMID: 30374065 |