Primary Site >> Esophagus Cancer

Gene >> MTOR

Journal: Carcinogenesis. 2005 Jun;26(6):1035-43. Epub 2005 Feb 17.
Title: Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells.
Author: Chen, Jingyuan|Yan, Yan|Li, Jingxia|Ma, Qian|Stoner, Gary D|Ye, Jianping|Huang, Chuanshu
PMID: 15718251
Journal: Int J Oncol. 2007 Mar;30(3):605-13.
Title: Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines.
Author: Faried, A|Kurnia, D|Faried, L S|Usman, N|Miyazaki, T|Kato, H|Kuwano, H
PMID: 17273761
Journal: Cancer Res. 2008 Apr 15;68(8):2632-40.
Title: Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.
Author: Yen, Chia-Jui|Izzo, Julie G|Lee, Dung-Fang|Guha, Sushovan|Wei, Yongkun|Wu, Tsung-Teh|Chen, Chun-Te|Kuo, Hsu-Ping|Hsu, Jung-Mao|Sun, Hui-Lung|Chou, Chao-Kai|Buttar, Navtej S|Wang, Kenneth K|Huang, Peng|Ajani, Jaffer|Hung, Mien-Chie
PMID: 18413730
Journal: Oncol Rep. 2008 Dec;20(6):1473-7.
Title: TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.
Author: Wang, Zhi Gang|Fukazawa, Takuya|Nishikawa, Toshio|Watanabe, Nobuyuki|Sakurama, Kazufumi|Motoki, Takayuki|Takaoka, Munenori|Hatakeyama, Shinji|Omori, Osamu|Ohara, Toshiaki|Tanabe, Shunsuke|Fujiwara, Yasuhiro|Shirakawa, Yasuhiro|Yamatsuji, Tomoki|Tanaka, No
PMID: 19020730
Journal: J Clin Oncol. 2009 Feb 20;27(6):857-71.
Title: Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
Author: Hildebrandt, Michelle A T|Yang, Hushan|Hung, Mien-Chie|Izzo, Julie G|Huang, Maosheng|Lin, Jie|Ajani, Jaffer A|Wu, Xifeng
PMID: 19164214
Journal: Oncol Rep. 2010 Apr;23(4):1167-72.
Title: RAD001 offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer.
Author: Wang, Zhi Gang|Fukazawa, Takuya|Nishikawa, Toshio|Watanabe, Nobuyuki|Sakurama, Kazufumi|Motoki, Takayuki|Hatakeyama, Shinji|Omori, Osamu|Ohara, Toshiaki|Tanabe, Shunsuke|Fujiwara, Yasuhiro|Takaoka, Munenori|Shirakawa, Yasuhiro|Yamatsuji, Tomoki|Tanaka, No
PMID: 20204306
Journal: Ann Surg Oncol. 2010 Sep;17(9):2486-93.
Title: Phosphorylated mTOR expression is associated with poor prognosis for patients with esophageal squamous cell carcinoma.
Author: Hirashima, Kotaro|Baba, Yoshifumi|Watanabe, Masayuki|Karashima, Ryu-ichi|Sato, Nobutaka|Imamura, Yu|Hiyoshi, Yukiharu|Nagai, Yohei|Hayashi, Naoko|Iyama, Ken-ichi|Baba, Hideo
PMID: 20339946
Journal: Cancer Biol Ther. 2011 Jun 1;11(11):950-8. Epub 2011 Jun 1.
Title: The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells.
Author: Li, Hongxia|Gao, Quanli|Guo, Liping|Lu, Shih Hsin
PMID: 21467840
Journal: Cancer Cell. 2012 Mar 20;21(3):374-87.
Title: The crosstalk of mTOR/S6K1 and Hedgehog pathways.
Author: Wang, Yan|Ding, Qingqing|Yen, Chia-Jui|Xia, Weiya|Izzo, Julie G|Lang, Jing-Yu|Li, Chia-Wei|Hsu, Jennifer L|Miller, Stephanie A|Wang, Xuemei|Lee, Dung-Fang|Hsu, Jung-Mao|Huo, Longfei|Labaff, Adam M|Liu, Dongping|Huang, Tzu-Hsuan|Lai, Chien-Chen|Tsai, Fuu-J
PMID: 22439934
Journal: Cell Cycle. 2012 Nov 1;11(21):3997-4008.
Title: Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway.
Author: Werneck, Miriam B F|Hottz, Eugenio|Bozza, Patricia T|Viola, Joao P B
PMID: 22992618
Journal: Ginekol Pol. 2013 Apr;84(4):293-7.
Title: Inflammation and ovarian cancer--current views.
Author: Kisielewski, Rafal|Tolwinska, Agnieszka|Mazurek, Andrzej|Laudanski, Piotr
PMID: 23700863
Journal: Cell Physiol Biochem. 2013;32(5):1178-86.
Title: Metformin inhibits esophagus cancer proliferation through upregulation of USP7.
Author: Xu, Yunhua|Lu, Shun
PMID: 24335168
Journal: Expert Opin Emerg Drugs. 2013 Jun;18(2):219-30.
Title: Emerging tyrosine kinase inhibitors for esophageal cancer.
Author: Ku, Geoffrey Y|Ilson, David H
PMID: 23725567
Journal: World J Gastroenterol. 2013 Mar 21;19(11):1736-48.
Title: Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation.
Author: Pang, Xue-Li|He, Gang|Liu, Yang-Bo|Wang, Yan|Zhang, Bo
PMID: 23555162
Journal: Cancer Biol Ther. 2013 Mar;14(3):230-6.
Title: Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice.
Author: Nishikawa, Toshio|Takaoka, Munenori|Ohara, Toshiaki|Tomono, Yasuko|Hao, Huifang|Bao, Xiaohong|Fukazawa, Takuya|Wang, Zhigang|Sakurama, Kazufumi|Fujiwara, Yasuhiro|Motoki, Takayuki|Shirakawa, Yasuhiro|Yamatsuji, Tomoki|Tanaka, Noriaki|Fujiwara, Toshiyoshi|
PMID: 23291985
Journal: Hum Pathol. 2013 Feb;44(2):226-36.
Title: Clinicopathologic significance and function of mammalian target of rapamycin activation in esophageal squamous cell carcinoma.
Author: Kim, Seok-Hyung|Chau, Gia Cac|Jang, Young Hoon|Lee, Seung Im|Pyo, Suhkneung|Um, Sung Hee
PMID: 22944293
Journal: Chin Med J (Engl). 2014;127(2):353-8.
Title: Insulin enhances apoptosis induced by cisplatin in human esophageal squamous cell carcinoma EC9706 cells related to inhibition of autophagy.
Author: Yang, Yang|Wen, Fengbiao|Dang, Lifeng|Fan, Yuxia|Liu, Donglei|Wu, Kai|Zhao, Song
PMID: 24438628
Journal: Crit Rev Oncol Hematol. 2014 Aug;91(2):186-96.
Title: Targeted therapies in metastatic esophageal cancer: advances over the past decade.
Author: Mohamed, Amr|El-Rayes, Bassel|Khuri, Fadlo R|Saba, Nabil F
PMID: 24582516
Journal: Am Soc Clin Oncol Educ Book. 2014:e172-8.
Title: New directions in perioperative management of locally advanced esophagogastric cancer.
Author: Burtness, Barbara|Ilson, David|Iqbal, Syma
PMID: 24857100
Journal: Int J Oncol. 2014 Aug;45(2):567-74.
Title: Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer.
Author: Honjo, Soichiro|Ajani, Jaffer A|Scott, Ailing W|Chen, Qiongrong|Skinner, Heath D|Stroehlein, John|Johnson, Randy L|Song, Shumei
PMID: 24859412
Journal: Oncol Lett. 2014 Aug;8(2):575-581. Epub 2014 May 27.
Title: Inhibition of mammalian target of rapamycin by rapamycin increases the radiosensitivity of esophageal carcinoma Eca109 cells.
Author: Zhang, Dejun|Xiang, Jie|Gu, Yuming|Xu, Wei|Xu, Hao|Zu, Maoheng|Pei, Dongsheng|Zheng, Junnian
PMID: 25009644
Journal: Oncol Rep. 2014 Oct;32(4):1409-18.
Title: MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma.
Author: Zhang, Naijian|Fu, Hailong|Song, Leilei|Ding, Youhong|Wang, Xiufang|Zhao, Chao|Zhao, Yiqi|Jiao, Feng|Zhao, Yaping
PMID: 25109390
Journal: Oncotarget. 2015 Dec 8;6(39):42183-96.
Title: Mutant HRAS as novel target for MEK and mTOR inhibitors.
Author: Kiessling, Michael K|Curioni-Fontecedro, Alessandra|Samaras, Panagiotis|Atrott, Kirstin|Cosin-Roger, Jesus|Lang, Silvia|Scharl, Michael|Rogler, Gerhard
PMID: 26544513
Journal: Int J Oncol. 2015 Dec;47(6):2255-63.
Title: Molecular characterization of antitumor effects of the rhizome extract from Curcuma zedoaria on human esophageal carcinoma cells.
Author: Hadisaputri, Yuni Elsa|Miyazaki, Tatsuya|Suzuki, Shigemasa|Kubo, Norio|Zuhrotun, Ade|Yokobori, Takehiko|Abdulah, Rizky|Yazawa, Shin|Kuwano, Hiroyuki
PMID: 26498695
Journal: Oncotarget. 2015 Oct 20;6(32):33438-55.
Title: Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation.
Author: Kresty, Laura A|Weh, Katherine M|Zeyzus-Johns, Bree|Perez, Laura N|Howell, Amy B
PMID: 26378019
Journal: Biochem Biophys Res Commun. 2015 Sep 11;465(1):137-44.
Title: The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121.
Author: Peng, Yi|Zhou, Yajuan|Cheng, Long|Hu, Desheng|Zhou, Xiaoyi|Wang, Zhaohua|Xie, Conghua|Zhou, Fuxiang
PMID: 26235881
Journal: APMIS. 2015 Aug;123(8):639-47.
Title: Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma.
Author: Tasioudi, Konstantia E|Sakellariou, Stratigoula|Levidou, Georgia|Theodorou, Dimitrios|Michalopoulos, Nikolaos V|Patsouris, Efstratios|Korkolopoulou, Penelope|Saetta, Angelica A
PMID: 25912437
Journal: Drug Des Devel Ther. 2015 Feb 17;9:993-1026.
Title: Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.
Author: Wang, Yan-Yang|Yang, Yin-Xue|Zhao, Ren|Pan, Shu-Ting|Zhe, Hong|He, Zhi-Xu|Duan, Wei|Zhang, Xueji|Yang, Tianxin|Qiu, Jia-Xuan|Zhou, Shu-Feng
PMID: 25733817
Journal: Biomed Pharmacother. 2015 Feb;69:260-6.
Title: Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK.
Author: Feng, Tingting|Li, Lei|Ling, Sunbin|Fan, Ning|Fang, Meiyu|Zhang, Haiquan|Fang, Xin|Lan, Wen|Hou, Zhaoyuan|Meng, QingChun|Jin, Di|Xu, Fei|Li, Yan
PMID: 25661368
Journal: Cancer Chemother Pharmacol. 2015 Jul;76(1):61-7.
Title: Phase II trial of everolimus in patients with refractory metastatic adenocarcinoma of the esophagus, gastroesophageal junction and stomach: possible role for predictive biomarkers.
Author: Wainberg, Zev A|Soares, Heloisa P|Patel, Ravi|DiCarlo, Brian|Park, David J|Liem, Andre|Wang, He-jing|Yonemoto, Lisa|Martinez, Diego|Laux, Isett|Brennan, Meghan|Hecht, J Randolph
PMID: 25969130
Journal: Tumour Biol. 2016 Feb;37(2):1853-62.
Title: Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway.
Author: Yang, Yan|Sun, Xiangdong|Yang, Yuehua|Yang, Xi|Zhu, Hongcheng|Dai, Shengbin|Chen, Xiaochen|Zhang, Hao|Guo, Qing|Song, Yaqi|Wang, Feng|Cheng, Hongyan|Sun, Xinchen
PMID: 26318432
Journal: Mol Med Rep. 2016 Aug;14(2):1531-7.
Title: Vitamin E succinate induces apoptosis via the PI3K/AKT signaling pathways in EC109 esophageal cancer cells.
Author: Yang, Peng|Zhao, Jiaying|Hou, Liying|Yang, Lei|Wu, Kun|Zhang, Linyou
PMID: 27357907
Journal: Oncotarget. 2016 Aug 2;7(31):49334-49348.
Title: Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Author: Son, Sung Wook|Kim, Seok-Hyung|Moon, Eun-Yi|Kim, Dong-Hoon|Pyo, Suhkneung|Um, Sung Hee
PMID: 27384996
Journal: Med Sci Monit. 2016 Jul 25;22:2624-34.
Title: Thioridazine Sensitizes Esophageal Carcinoma Cell Lines to Radiotherapy-Induced Apoptosis In Vitro and In Vivo.
Author: Li, Hongxia|Juan, Li|Xia, Leiming|Wang, Yi|Bao, Yangyi|Sun, Guoping
PMID: 27453171
Journal: Oncotarget. 2016 Oct 11;7(41):67150-67165.
Title: Angiotensin II type I receptor (AT1R) is an independent prognosticator of esophageal squamous cell carcinoma and promotes cells proliferation via mTOR activation.
Author: Li, Shau-Hsuan|Lu, Hung-I|Chang, Alice Y W|Huang, Wan-Ting|Lin, Wei-Che|Lee, Ching-Chang|Tien, Wan-Yu|Lan, Ya-Chun|Tsai, Hsin-Ting|Chen, Chang-Han
PMID: 27564102
Journal: Toxicol Lett. 2016 Nov 2;261:49-58.
Title: beta-Carotene synergistically enhances the anti-tumor effect of 5-fluorouracil on esophageal squamous cell carcinoma in vivo and in vitro.
Author: Zhang, Yanting|Zhu, Xiangzhan|Huang, Tuanjie|Chen, Lei|Liu, Yanxia|Li, Qinghua|Song, Jishi|Ma, Shanshan|Zhang, Kun|Yang, Bo|Guan, Fangxia
PMID: 27586268
Journal: Oncotarget. 2016 Oct 11;7(41):67612-67625.
Title: Gene-gene interactions in gastrointestinal cancer susceptibility.
Author: Kim, Jineun|Yum, Seoyun|Kang, Changwon|Kang, Suk-Jo
PMID: 27588484
Journal: Oncol Rep. 2017 Jun;37(6):3590-3596.
Title: MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway.
Author: Qiu, Yun-Tan|Wang, Wen-Jun|Zhang, Bing|Mei, Li-Li|Shi, Zhi-Zhou
PMID: 28498460
Journal: Klin Onkol. 2017 Winter;30(Supplementum3):50-54.
Title: [Checkpoint Inhibitors in the Treatment of Upper Gastrointestinal Tract Tumors].
Author: Obermannova, R
PMID: 29239193
Journal: Biochem Biophys Res Commun. 2017 Sep 1. pii: S0006-291X(17)31730-8.
Title: Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma.
Author: Wang, Shao-Qi|Wang, Xiao|Zheng, Kai|Liu, Kai-Sheng|Wang, Shao-Xiang|Xie, Cong-Hua
PMID: 28867195
Journal: J Cell Biochem. 2017 Aug 31.
Title: FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma.
Author: Shi, Yuanyuan|Liu, Xuejiao|Fredimoses, Mangaladoss|Song, Mengqiu|Chen, Hanyong|Liu, Kangdong|Lee, Mee-Hyun|Dong, Zigang
PMID: 28857247
Journal: Tumour Biol. 2017 Jun;39(6):1010428317705748.
Title: Endoplasmic reticulum stress could induce autophagy and apoptosis and enhance chemotherapy sensitivity in human esophageal cancer EC9706 cells by mediating PI3K/Akt/mTOR signaling pathway.
Author: Zhou, Fang|Li, Yan-Hua|Wang, Jian-Jun|Pan, Jia|Lu, Hong
PMID: 28631572
Journal: Dis Markers. 2017;2017:8317913.
Title: miR-195 Regulates Proliferation and Apoptosis through Inhibiting the mTOR/p70s6k Signaling Pathway by Targeting HMGA2 in Esophageal Carcinoma Cells.
Author: Li, Yong|Wu, Dapeng|Wang, Pei|Li, Xiaohui|Shi, Gongning
PMID: 28487599
Journal: Med Sci Monit. 2017 May 2;23:2096-2103.
Title: Capilliposide C Sensitizes Esophageal Squamous Carcinoma Cells to Oxaliplatin by Inducing Apoptosis Through the PI3K/Akt/mTOR Pathway.
Author: Shen, Zhipeng|Xu, Lixia|Li, Juan|Zhang, Ni
PMID: 28463955
Journal: Med Oncol. 2017 Mar;34(3):32.
Title: RICTOR expression in esophageal squamous cell carcinoma and its clinical significance.
Author: Jiang, Wei-Jia|Feng, Ru-Xue|Liu, Jia-Tao|Fan, Lu-Lu|Wang, Hua|Sun, Guo-Ping
PMID: 28132115
Journal: Oncotarget. 2017 Jan 31;8(5):8536-8549.
Title: The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKalpha/mTOR pathway in vitro and in vivo.
Author: Fujihara, Shintaro|Morishita, Asahiro|Ogawa, Kana|Tadokoro, Tomoko|Chiyo, Taiga|Kato, Kiyohito|Kobara, Hideki|Mori, Hirohito|Iwama, Hisakazu|Masaki, Tsutomu
PMID: 28052030
Journal: Cancer Res Treat. 2017 Jul;49(3):778-789.
Title: Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo.
Author: Tang, Jian-Cai|An, Rui|Jiang, Yi-Qing|Yang, Jian
PMID: 27857021
Journal: J Cancer. 2018 Jan 1;9(1):32-40.
Title: Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo.
Author: Tang, Jian-Cai|Zhao, Jia|Long, Feng|Chen, Jian-Ye|Mu, Bo|Jiang, Zhen|Ren, Yonggan|Yang, Jian
PMID: 29290767
Journal: Mol Med Rep. 2018 Mar;17(3):4599-4604.
Title: Vitexin induces G2/Mphase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells.
Author: Zhang, Guangning|Li, Dongyuan|Chen, Hao|Zhang, Junchen|Jin, Xingyi
PMID: 29328424
Journal: Asia Pac J Clin Oncol. 2018 Jan 30.
Title: Serum-based six-miRNA signature as a potential marker for EC diagnosis: Comparison with TCGA miRNAseq dataset and identification of miRNA-mRNA target pairs by integrated analysis of TCGA miRNAseq and RNAseq datasets.
Author: Sharma, Priyanka|Saraya, Anoop|Sharma, Rinu
PMID: 29380534
Journal: Technol Cancer Res Treat. 2018 Jan 1;17:1533033818758772.
Title: The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma.
Author: Wu, Ning|Du, Zunguo|Zhu, Yongjun|Song, Yang|Pang, Liewen|Chen, Zhiming
PMID: 29463194
Journal: Oncol Lett. 2018 Jun;15(6):9339-9346.
Title: Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway.
Author: Ding, Yan|Liu, Wei|Wang, Xiaoling|Zhang, Lingling|Zhao, Meng|Deng, Huiyan|Liu, Yueping
PMID: 29805658
Journal: Mol Carcinog. 2018 Jul 23.
Title: Quercetin-3-methyl ether inhibits esophageal carcinogenesis by targeting the AKT/mTOR/p70S6K and MAPK pathways.
Author: Zhao, Simin|Jiang, Yanan|Zhao, Jimin|Li, Honglin|Yin, Xueshan|Wang, Yanhong|Xie, Yifei|Chen, Xinhuan|Lu, Jing|Dong, Ziming|Liu, Kangdong
PMID: 30035335
Journal: Cell Death Dis. 2018 Jul 26;9(8):817.
Title: Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways.
Author: Cao, Jinlin|Lv, Wang|Wang, Luming|Xu, Jinming|Yuan, Ping|Huang, Sha|He, Zhehao|Hu, Jian
PMID: 30050135
Journal: Cancer Sci. 2018 Aug 10.
Title: TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway.
Author: Xiong, Dian|Jin, Chun|Ye, Xudong|Qiu, Baiquan|Jianjun, Xu|Zhu, Shuqiang|Xiang, Long|Wu, Haibo|Yongbing, Wu
PMID: 30098109
Journal: J Thorac Dis. 2018 Jul;10(7):3983-3991.
Title: Genetic and pharmacological inhibition of eIF4E effectively targets esophageal cancer cells and augments 5-FU's efficacy.
Author: Kai, Jindan|Wang, Yiqiao|Xiong, Fei|Wang, Sheng
PMID: 30174840
Journal: J Cell Biochem. 2018 Sep 19.
Title: Oridonin-induced mitochondria-dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways.
Author: Jiang, Jin-Huan|Pi, Jiang|Jin, Hua|Cai, Ji-Ye
PMID: 30229997
Journal: Med Sci Monit. 2018 Oct 28;24:7689-7696.
Title: Long Non-Coding RNA (lncRNA) Growth Arrest Specific 5 (GAS5) Suppresses Esophageal Squamous Cell Carcinoma Cell Proliferation and Migration by Inactivating Phosphatidylinositol 3-kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway.
Author: Wang, Guojun|Sun, Junfeng|Zhao, Hongchao|Li, Haohao
PMID: 30368517