Literatures

Primary Site >> Stomach Cancer

Gene >> MTHFR

1.
Journal:	Int J Cancer. 2001 Sep 20;95(5):332-6.
Title:	Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of gastric cancer in a Chinese population: a case-control study.
Author:	Shen, H\|Xu, Y\|Zheng, Y\|Qian, Y\|Yu, R\|Qin, Y\|Wang, X\|Spitz, M R\|Wei, Q
PMID:	11494235

2.
Journal:	Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Aug;23(4):289-92.
Title:	[Polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of stomach cancer].
Author:	Gao, Changming\|Wu, Jianzhong\|Ding, Jianhua\|Liu, Yanting\|Zang, Yu\|Li, Suping\|Su, Ping\|Hu, Xu\|Xu, Tianliang\|Toshiro, Takezaki\|Kazuo, Tajima
PMID:	12411076

3.
Journal:	Suppl Tumori. 2003 Sep-Oct;2(5):S19-22.
Title:	Pharmacogenetics of stomach cancer.
Author:	Toffoli, Giuseppe\|Cecchin, Erika
PMID:	12914384

4.
Journal:	Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Jul;24(7):599-603.
Title:	[Interactions between lifestyle, methylanetetrahydrofolate reductase gene and polymorphisms in thymidylate synthase gene with risk of stomach cancer].
Author:	Gao, Chang-ming\|Wu, Jian-zhong\|Liu, Yan-ting\|Ding, Jian-hua\|Li, Su-ping\|Su, Ping\|Hu, Xu\|Kai, Hai-tao\|Toshiro, Takezaki\|Kazuo, Tajima
PMID:	12975018

5.
Journal:	Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Jun;25(6):495-8.
Title:	[A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer].
Author:	Mu, Li-Na\|Ding, Bao-Guo\|Chen, Chuan-Wei\|Wei, Guo-Rong\|Zhou, Xue-Fu\|Wang, Ru-Hong\|Cai, Lin\|Zhang, Zuo-Feng\|Jiang, Qing-Wu\|Yu, Shun-Zhang
PMID:	15231125

6.
Journal:	Asian Pac J Cancer Prev. 2004 Apr-Jun;5(2):133-8.
Title:	Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking.
Author:	Gao, Chang-Ming\|Takezaki, Toshiro\|Wu, Jian-Zhong\|Liu, Yan-Ting\|Ding, Jian-Hua\|Li, Su-Ping\|Su, Ping\|Hu, Xu\|Kai, Hai-Tao\|Li, Zong-You\|Matsuo, Keitaro\|Hamajima, Nobuyuki\|Sugimura, Haruhiko\|Tajima, Kazuo
PMID:	15244514

7.
Journal:	Ai Zheng. 2004 Aug;23(8):958-62.
Title:	[Relationship of methylenetetrahydrofolate reductase C677T polymorphism and chemosensitivity to 5-fluorouracil in gastric carcinoma].
Author:	Lu, Jian-Wei\|Gao, Chang-Ming\|Wu, Jian-Zhong\|Sun, Xiao-Feng\|Wang, Li\|Feng, Ji-Feng
PMID:	15301724

8.
Journal:	Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Dec;25(12):1054-8.
Title:	[Polymorphism of methylenetetrahydrofolate reductase and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy].
Author:	Gao, Chang-Ming\|Lu, Jian-Wei\|Toshiro, Takezaki\|Wu, Jian-Zhong\|Cao, Hai-Xia\|Chen, Huan-Qiu\|Feng, Ji-Feng\|Kazuo, Tajima
PMID:	15769364

9.
Journal:	Oncol Rep. 2005 Feb;13(2):355-60.
Title:	Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China.
Author:	Shen, Hongbing\|Newmann, Ana S\|Hu, Zhibin\|Zhang, Zhengdong\|Xu, Yaochu\|Wang, Liwei\|Hu, Xu\|Guo, Jiangtao\|Wang, Xinru\|Wei, Qingyi
PMID:	15643524

10.
Journal:	Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Oct;26(10):794-9.
Title:	[The relationship between methylenetetrahydrofolate reductase gene polymorphism and microsatellite instability in gastric cancer].
Author:	Si, Pei-ren\|Fang, Dian-chun\|Zhang, Hao\|Yang, Liu-qin\|Luo, Yuan-hui\|Liao, Hua-yu
PMID:	16536307

11.
Journal:	Anticancer Res. 2005 May-Jun;25(3B):2249-52.
Title:	Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population.
Author:	Kim, Jin Kyeoung\|Kim, Sehyun\|Han, Jin Hee\|Kim, Hyo Jin\|Chong, So Young\|Hong, Seong Pyo\|Hwang, Seong Gyu\|Ahn, Jung Yong\|Cha, Kwang Yul\|Oh, Doyeun\|Kim, Nam Keun
PMID:	16158971

12.
Journal:	Korean J Gastroenterol. 2005 Jul;46(1):32-8.
Title:	[Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer].
Author:	Lee, Jun\|Jeong, Cheol Kweon\|Hong, Sung Pyo\|Chong, So Young\|Oh, Doyeun\|Hwang, Seong Gyu\|Ahn, Dae Ho\|Kim, Sehyun\|Han, Jin Hee\|Kim, Nam Keun
PMID:	16030402

13.
Journal:	Eur J Cancer. 2006 Mar;42(4):528-33. Epub 2005 Dec 15.
Title:	Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico.
Author:	Lacasana-Navarro, Marina\|Galvan-Portillo, Marcia\|Chen, Jia\|Lopez-Cervantes, Malaquias\|Lopez-Carrillo, Lizbeth
PMID:	16359859

14.
Journal:	World J Gastroenterol. 2006 Dec 21;12(47):7591-7.
Title:	Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis.
Author:	Weng, Yu-Rong\|Sun, Dan-Feng\|Fang, Jing-Yuan\|Gu, Wei-Qi\|Zhu, Hong-Yin
PMID:	17171786

15.
Journal:	Adv Exp Med Biol. 2006;587:115-20.
Title:	Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract.
Author:	Hofler, Heinz\|Langer, Rupert\|Ott, Katja\|Keller, Gisela
PMID:	17163161

16.
Journal:	Gastroenterology. 2006 Oct;131(4):1271-83. Epub 2006 Aug 5.
Title:	Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.
Author:	Larsson, Susanna C\|Giovannucci, Edward\|Wolk, Alicja
PMID:	17030196

17.
Journal:	Int J Cancer. 2006 Dec 15;119(12):2885-94.
Title:	The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor-related survival in neoadjuvant treated locally advanced gastric cancer.
Author:	Ott, Katja\|Vogelsang, Holger\|Marton, Noemi\|Becker, Karen\|Lordick, Florian\|Kobl, Michael\|Schuhmacher, Christoph\|Novotny, Alexander\|Mueller, James\|Fink, Ulrich\|Ulm, Kurt\|Siewert, Jorg Rudiger\|Hofler, Heinz\|Keller, Gisela
PMID:	16929515

18.
Journal:	Anticancer Res. 2006 Jul-Aug;26(4B):2879-81.
Title:	Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia.
Author:	Kim, Nam Keun\|Chong, So Young\|Jang, Moon Ju\|Hong, Seung Ho\|Kim, Heung Sik\|Cho, Eun Kyung\|Lee, Jung Ae\|Ahn, Myung Ju\|Kim, Chul Soo\|Oh, Doyeun
PMID:	16886608

19.
Journal:	J Hum Genet. 2006;51(7):618-24. Epub 2006 Jun 7.
Title:	Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis.
Author:	Zintzaras, Elias
PMID:	16758123

20.
Journal:	J Clin Oncol. 2006 Apr 20;24(12):1883-91.
Title:	Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy.
Author:	Ruzzo, Annamaria\|Graziano, Francesco\|Kawakami, Kazuyuki\|Watanabe, Go\|Santini, Daniele\|Catalano, Vincenzo\|Bisonni, Renato\|Canestrari, Emanuele\|Ficarelli, Rita\|Menichetti, Ettore Tito\|Mari, Davide\|Testa, Enrica\|Silva, Rosarita\|Vincenzi, Bruno\|Giordani, Paol
PMID:	16622263

21.
Journal:	Int J Cancer. 2006 Feb 1;118(3):628-32.
Title:	Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population.
Author:	Graziano, Francesco\|Kawakami, Kazuyuki\|Ruzzo, Annamaria\|Watanabe, Go\|Santini, Daniele\|Pizzagalli, Francesca\|Bisonni, Renato\|Mari, Davide\|Floriani, Irene\|Catalano, Vincenzo\|Silva, Rosarita\|Tonini, Giuseppe\|Torri, Valter\|Giustini, Lucio\|Magnani, Mauro
PMID:	16094648

22.
Journal:	Clin Cancer Res. 2007 Apr 15;13(8):2526-32.
Title:	Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population.
Author:	Wang, Lina\|Ke, Qiao\|Chen, Wensen\|Wang, Jianming\|Tan, Yongfei\|Zhou, Yan\|Hua, Zhaolai\|Ding, Weiliang\|Niu, Juying\|Shen, Jing\|Zhang, Zuofeng\|Wang, Xinru\|Xu, Yaochu\|Shen, Hongbing
PMID:	17438114

23.
Journal:	Rev Gastroenterol Mex. 2007 Oct-Dec;72(4):355-8.
Title:	[C677T polymorphism of the MTHFR gene and the risk of developing distal gastric cancer in a Mexican population].
Author:	Zuniga-Noriega, Jaime Raul\|Velazco-Campos, Maria del Roble\|Aguirre-Rodriguez, Alejandra\|Villarreal, Laura Martinez-de\|Garza-Gonzalez, Elvira\|Maldonado-Garza, Hector Jesus\|Bosques-Padilla, Francisco Javier
PMID:	18595323

24.
Journal:	J Nanosci Nanotechnol. 2007 Sep;7(9):3245-9.
Title:	Application of microarray-based method for methylenetetrahydrofolate reductase (MTHFR) polymorphisms in the risk of gastric carcinoma in east China population.
Author:	Li, Song\|Ji, Meiju\|He, Nongyue\|Lu, Zuhong
PMID:	18019157

25.
Journal:	Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2416-24.
Title:	The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.
Author:	Vollset, Stein Emil\|Igland, Jannicke\|Jenab, Mazda\|Fredriksen, Ase\|Meyer, Klaus\|Eussen, Simone\|Gjessing, Hakon K\|Ueland, Per Magne\|Pera, Guillem\|Sala, Nuria\|Agudo, Antonio\|Capella, Gabriel\|Del Giudice, Giuseppe\|Palli, Domenico\|Boeing, Heiner\|Weikert, Corne
PMID:	18006931

26.
Journal:	Biomarkers. 2007 Nov-Dec;12(6):635-44.
Title:	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population.
Author:	Boccia, Stefania\|Gianfagna, Francesco\|Persiani, Roberto\|La Greca, Antonio\|Arzani, Dario\|Rausei, Stefano\|D'ugo, Domenico\|Magistrelli, Paolo\|Villari, Paolo\|Van Duijn, Cornelia M\|Ricciardi, Gualtiero
PMID:	17972183

27.
Journal:	Biomarkers. 2007 Jan-Feb;12(1):61-75.
Title:	Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer.
Author:	Mu, L N\|Cao, W\|Zhang, Z F\|Yu, S Z\|Jiang, Q W\|You, N C\|Lu, Q Y\|Zhou, X F\|Ding, B G\|Chang, J\|Chen, C W\|Wei, G R\|Cai, L
PMID:	17438654

28.
Journal:	Cell Biochem Funct. 2007 Jul-Aug;25(4):419-22.
Title:	Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer.
Author:	Zeybek, Umit\|Yaylim, Ilhan\|Yilmaz, Hulya\|Agachan, Bedia\|Ergen, Arzu\|Arikan, Soykan\|Bayrak, Savas\|Isbir, Turgay
PMID:	16927418

29.
Journal:	Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):115-21.
Title:	Genetic polymorphisms in folate metabolism and the risk of stomach cancer.
Author:	Zhang, Fang Fang\|Terry, Mary Beth\|Hou, Lifang\|Chen, Jinbo\|Lissowska, Jolanta\|Yeager, Meredith\|Zatonski, Witold\|Chanock, Stephen\|Morabia, Alfredo\|Chow, Wong-Ho
PMID:	17220339

30.
Journal:	Cancer Lett. 2007 Jun 28;251(2):228-36. Epub 2007 Jan 8.
Title:	Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer.
Author:	Gotze, Tobias\|Rocken, Christoph\|Rohl, Friedrich W\|Wex, Thomas\|Hoffmann, Juliane\|Westphal, Sabine\|Malfertheiner, Peter\|Ebert, Matthias P A\|Dierkes, Jutta
PMID:	17208363

31.
Journal:	Recent Results Cancer Res. 2007;176:33-6.
Title:	Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract.
Author:	Hofler, Heinz\|Langer, Rupert\|Ott, Katja\|Keller, Gisela
PMID:	17607914

32.
Journal:	Curr Genomics. 2008 Sep;9(6):361-74.
Title:	A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk.
Author:	Gianfagna, Francesco\|De Feo, Emma\|van Duijn, Cornelia M\|Ricciardi, Gualtiero\|Boccia, Stefania
PMID:	19506726

33.
Journal:	Eur J Cancer Prev. 2008 Oct;17(5):446-52.
Title:	Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis.
Author:	Sun, Liang\|Sun, Ye-Huan\|Wang, Bo\|Cao, Hong-Yuan\|Yu, Chen
PMID:	18714187

34.
Journal:	JAMA. 2008 May 28;299(20):2423-36.
Title:	Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
Author:	Dong, Linda M\|Potter, John D\|White, Emily\|Ulrich, Cornelia M\|Cardon, Lon R\|Peters, Ulrike
PMID:	18505952

35.
Journal:	Cell Biol Int. 2008 Aug;32(8):879-87.
Title:	Knock-down of methylenetetrahydrofolate reductase reduces gastric cancer cell survival: an in vitro study.
Author:	Sun, Dan-Feng\|Weng, Yu-Rong\|Chen, Ying-Xuan\|Lu, Rong\|Wang, Xia\|Fang, Jing-Yuan
PMID:	18486501

36.
Journal:	J Hum Genet. 2008;53(4):340-8.
Title:	Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Author:	Mao, Renfang\|Fan, Yihui\|Jin, Yan\|Bai, Jing\|Fu, Songbin
PMID:	18340404

37.
Journal:	Br J Cancer. 2008 Feb 26;98(4):832-9.
Title:	Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer.
Author:	Matsubara, J\|Nishina, T\|Yamada, Y\|Moriwaki, T\|Shimoda, T\|Kajiwara, T\|Nakajima, T E\|Kato, K\|Hamaguchi, T\|Shimada, Y\|Okayama, Y\|Oka, T\|Shirao, K
PMID:	18231104

38.
Journal:	Am J Epidemiol. 2008 Mar 1;167(5):505-16. Epub 2007 Dec 27.
Title:	Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.
Author:	Boccia, Stefania\|Hung, Rayjean\|Ricciardi, Gualtiero\|Gianfagna, Francesco\|Ebert, Matthias P A\|Fang, Jing-Yuan\|Gao, Chang-Ming\|Gotze, Tobias\|Graziano, Francesco\|Lacasana-Navarro, Marina\|Lin, Dongxin\|Lopez-Carrillo, Lizbeth\|Qiao, You-Lin\|Shen, Hongbing\|Stolz
PMID:	18162478

39.
Journal:	Cancer Chemother Pharmacol. 2009 Apr;63(5):911-8.
Title:	The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.
Author:	Huang, Zhao-Hui\|Hua, Dong\|Li, Li-Hua
PMID:	18704422

40.
Journal:	J Clin Oncol. 2009 Jun 10;27(17):2863-73.
Title:	Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie.
Author:	Goekkurt, Eray\|Al-Batran, Salah-Eddin\|Hartmann, Jorg T\|Mogck, Ulrike\|Schuch, Gunter\|Kramer, Michael\|Jaeger, Elke\|Bokemeyer, Carsten\|Ehninger, Gerhard\|Stoehlmacher, Jan
PMID:	19332728

41.
Journal:	J Toxicol Environ Health A. 2009;72(11-12):759-66.
Title:	Analysis and estimates of the attributable risk for environmental and genetic risk factors in gastric cancer in a Chinese population.
Author:	Shen, Xiaobing\|Zhang, Jiao\|Yan, Yingying\|Yang, Yufeng\|Fu, Gang\|Pu, Yuepu
PMID:	19492240

42.
Journal:	Biochem Genet. 2009 Oct;47(9-10):645-50.
Title:	MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis.
Author:	Palladino, Mariangela\|Chiusolo, Patrizia\|Reddiconto, Giovanni\|Marietti, Sara\|De Ritis, Daniela\|Leone, Giuseppe\|Sica, Simona
PMID:	19521764

43.
Journal:	Virchows Arch. 2010 Dec;457(6):627-33.
Title:	MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
Author:	Neves Filho, Eduardo Henrique Cunha\|Alves, Markenia Kelia Santos\|Lima, Valeska Portela\|Rabenhorst, Silvia Helena Barem
PMID:	20957490

44.
Journal:	Chemotherapy. 2010;56(4):313-7.
Title:	Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity.
Author:	Kim, Suk-Ran\|Park, Chang-Hun\|Park, Silvia\|Park, Joon-Oh\|Lee, Jeeyun\|Lee, Soo-Youn
PMID:	20714149

45.
Journal:	Anticancer Drugs. 2010 Sep;21(8):777-84.
Title:	A phase I/II and pharmacogenomic study of pemetrexed and cisplatin in patients with unresectable, advanced gastric carcinoma.
Author:	Chen, Jen-Shi\|Chao, Yee\|Bang, Yung-Jue\|Roca, Enrique\|Chung, Hyun C\|Palazzo, Felipe\|Kim, Yeul H\|Myrand, Scott P\|Mullaney, Brian P\|Shen, Li J\|Linn, Carlos
PMID:	20634689

46.
Journal:	BMC Cancer. 2010 May 26;10:236.
Title:	Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population.
Author:	Cui, Lian-Hua\|Shin, Min-Ho\|Kweon, Sun-Seog\|Kim, Hee Nam\|Song, Hye-Rim\|Piao, Jin-Mei\|Choi, Jin-Su\|Shim, Hyun Jeong\|Hwang, Jun Eul\|Kim, Hyeong-Rok\|Park, Young-Kyu\|Kim, Soo-Hyun
PMID:	20504332

47.
Journal:	Leuk Res. 2010 Dec;34(12):1596-600.
Title:	MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis.
Author:	Wang, Jing\|Zhan, Ping\|Chen, Bing\|Zhou, Rongfu\|Yang, Yonggong\|Ouyang, Jian
PMID:	20409583

48.
Journal:	Arch Med Res. 2010 Feb;41(2):125-33.
Title:	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis.
Author:	Dong, Xingli\|Wu, Jianing\|Liang, Peng\|Li, Jihong\|Yuan, Lijie\|Liu, Xinghan
PMID:	20470942

49.
Journal:	Cancer Sci. 2010 May;101(5):1247-54.
Title:	BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin.
Author:	Shim, Hyun Jeong\|Yun, Joo Young\|Hwang, Jun Eul\|Bae, Woo Kyun\|Cho, Sang Hee\|Lee, Ji Hee\|Kim, Hee Nam\|Shin, Min Ho\|Kweon, Sun Seog\|Lee, Jae Hyuk\|Kim, Hyeoung Joon\|Chung, Ik Joo
PMID:	20331623

50.
Journal:	Tumour Biol. 2010 Jan;31(1):23-32.
Title:	MTHFR polymorphisms in gastric cancer and in first-degree relatives of patients with gastric cancer.
Author:	De Re, Valli\|Cannizzaro, R\|Canzonieri, V\|Cecchin, E\|Caggiari, L\|De Mattia, E\|Pratesi, C\|De Paoli, P\|Toffoli, G
PMID:	20237899

51.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):28-38.
Title:	Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
Author:	Eussen, Simone J P M\|Vollset, Stein Emil\|Hustad, Steinar\|Midttun, Oivind\|Meyer, Klaus\|Fredriksen, Ase\|Ueland, Per Magne\|Jenab, Mazda\|Slimani, Nadia\|Ferrari, Pietro\|Agudo, Antonio\|Sala, Nuria\|Capella, Gabriel\|Del Giudice, Giuseppe\|Palli, Domenico\|Boeing, H
PMID:	20056620

52.
Journal:	Nutrition. 2010 Feb;26(2):201-8.
Title:	Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers.
Author:	Galvan-Portillo, Marcia V\|Onate-Ocana, Luis F\|Perez-Perez, Guillermo I\|Chen, Jia\|Herrera-Goepfert, Roberto\|Chihu-Amparan, Lilia\|Flores-Luna, Lourdes\|Mohar-Betancourt, Alejandro\|Lopez-Carrillo, Lizbeth
PMID:	19577428

53.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1311-9.
Title:	Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer.
Author:	Shitara, Kohei\|Muro, Kei\|Ito, Seiji\|Sawaki, Akira\|Tajika, Masahiro\|Kawai, Hiroki\|Yokota, Tomoya\|Takahari, Daisuke\|Shibata, Takashi\|Ura, Takashi\|Ito, Hidemi\|Hosono, Satoyo\|Kawase, Takakazu\|Watanabe, Miki\|Tajima, Kazuo\|Yatabe, Yasushi\|Tanaka, Hideo\|Matsuo,
PMID:	20447923

54.
Journal:	Int J Cancer. 2011 Feb 1;128(3):644-52.
Title:	Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls.
Author:	Zacho, Jeppe\|Yazdanyar, Shiva\|Bojesen, Stig E\|Tybjaerg-Hansen, Anne\|Nordestgaard, Borge G
PMID:	20473868

55.
Journal:	Ann Surg Oncol. 2011 Sep;18(9):2688-98.
Title:	DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy.
Author:	Ott, Katja\|Rachakonda, P Sivaramakrishna\|Panzram, Benjamin\|Keller, Gisela\|Lordick, Florian\|Becker, Karen\|Langer, Rupert\|Buechler, Markus\|Hemminki, Kari\|Kumar, Rajiv
PMID:	21347786

56.
Journal:	Cancer Lett. 2011 Dec 1;311(1):85-95.
Title:	Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
Author:	Balassiano, Karen\|Lima, Sheila\|Jenab, Mazda\|Overvad, Kim\|Tjonneland, Anne\|Boutron-Ruault, Marie Christine\|Clavel-Chapelon, Francoise\|Canzian, Federico\|Kaaks, Rudolf\|Boeing, Heiner\|Meidtner, Karina\|Trichopoulou, Antonia\|Laglou, Pagona\|Vineis, Paolo\|Panico,
PMID:	21831520

57.
Journal:	BMC Gastroenterol. 2012 Sep 29;12:137.
Title:	Polymorphisms in ERCC1, GSTs, TS and MTHFR predict clinical outcomes of gastric cancer patients treated with platinum/5-Fu-based chemotherapy: a systematic review.
Author:	Wang, Zhen\|Chen, Jun-qiang\|Liu, Jin-lu\|Qin, Xin-gan\|Huang, Yuan
PMID:	23020798

58.
Journal:	Genomics Inform. 2012 Sep;10(3):184-93.
Title:	Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans.
Author:	Yoo, Jae-Young\|Kim, Sook-Young\|Hwang, Jung-Ah\|Hong, Seung-Hyun\|Shin, Aesun\|Choi, Il Ju\|Lee, Yeon-Su
PMID:	23166529

59.
Journal:	Iran Biomed J. 2012;16(4):179-84.
Title:	Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection.
Author:	Saberi, Samaneh\|Zendehdel, Kazem\|Jahangiri, Sahar\|Talebkhan, Yeganeh\|Abdirad, Afshin\|Mohajerani, Nazanin\|Bababeik, Maryam\|Karami, Najmeh\|Esmaili, Maryam\|Oghalaie, Akbar\|Hassanpour, Parisa\|Amini, Neda\|Mohagheghi, Mohammad Ali\|Eshagh Hossieni, Mahmoud\|Moham
PMID:	23183616

60.
Journal:	Tumour Biol. 2013 Aug;34(4):2127-33.
Title:	Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian population.
Author:	do Nascimento Borges, Barbara\|Burbano, Rommel Mario Rodriguez\|Harada, Maria Lucia
PMID:	23504555

61.
Journal:	Pak J Med Sci. 2013 Nov;29(6):1338-43.
Title:	Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer.
Author:	Song, Binbin\|Ai, Jiang\|Kong, Xianghong\|Liu, Dexin\|Li, Jun
PMID:	24550949

62.
Journal:	Turk J Gastroenterol. 2013;24(2):117-21.
Title:	Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran.
Author:	Hosseini-Asl, S Saied\|Pourfarzi, Farhad\|Barzegar, Abazar\|Mazani, Mohammad\|Farahmand, Nima\|Niasti, Elham\|Yazdanbod, Abbas\|Didevar, Reza\|Akhavan, Homa\|Malekzadeh, Reza
PMID:	23934457

63.
Journal:	Asian Pac J Cancer Prev. 2013;14(5):3139-42.
Title:	Aberrant DNA methylation of P16, MGMT, hMLH1 and hMSH2 genes in combination with the MTHFR C677T genetic polymorphism in gastric cancer.
Author:	Xiong, Hai-Lin\|Liu, Xun-Qi\|Sun, Ai-Hua\|He, Ying\|Li, Jun\|Xia, Yuan
PMID:	23803092

64.
Journal:	Onkologie. 2013;36(6):335-40.
Title:	Relationship between glutathione S-transferase P1 (GSTP1), X-ray repair cross complementing group 1 (XRCC1) and 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene polymorphisms and response to chemotherapy in advanced gastric cancer.
Author:	Ji, Mei\|Xu, Bin\|Jiang, Jing-Ting\|Wu, Jun\|Li, Xiao-Dong\|Zhao, Wei-Qing\|Zhang, Hong-Yu\|Zhou, Wen-Jie\|Wu, Chang-Ping
PMID:	23774147

65.
Journal:	Asian Pac J Cancer Prev. 2013;14(1):299-302.
Title:	Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer.
Author:	Gao, Shang\|Ding, Li-Hong\|Wang, Jian-Wei\|Li, Cun-Bao\|Wang, Zhao-Yang
PMID:	23534741

66.
Journal:	Clin Transl Oncol. 2013 Aug;15(8):619-25.
Title:	Polymorphism of TS 3'-UTR predicts survival of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.
Author:	Gao, J\|He, Q\|Hua, D\|Mao, Y\|Li, Y\|Shen, L
PMID:	23263912

67.
Journal:	Genet Mol Res. 2014 Jan 24;13(4):9718-26.
Title:	Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site.
Author:	Chen, J\|Yuan, L\|Duan, Y Q\|Jiang, J Q\|Zhang, R\|Huang, Z J\|Xiao, X R
PMID:	24615072

68.
Journal:	PLoS One. 2014 Oct 22;9(10):e109235.
Title:	Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population.
Author:	Chang, Shen-Chih\|Chang, Po-Yin\|Butler, Brendan\|Goldstein, Binh Y\|Mu, Lina\|Cai, Lin\|You, Nai-Chieh Y\|Baecker, Aileen\|Yu, Shun-Zhang\|Heber, David\|Lu, Qing-Yi\|Li, Liming\|Greenland, Sander\|Zhang, Zuo-Feng
PMID:	25337902

69.
Journal:	Chin Med J (Engl). 2014;127(20):3562-7.
Title:	Polymorphism of methylenetetrahydrofolate reductase gene is associated with response to fluorouracil-based chemotherapy in Chinese patients with gastric cancer.
Author:	Zhang, Xiaoping\|Bai, Zhibin\|Chen, Baoan\|Feng, Jifeng\|Yan, Feng\|Jiang, Zhi\|Zhong, Yuejiao\|Wu, Jianzhong\|Cheng, Lu\|Lu, Zuhong\|Tong, Na\|Zhang, Zhengdong
PMID:	25316230

70.
Journal:	Med Oncol. 2014 Oct;31(10):196.
Title:	Screening of susceptibility genes and multi-gene risk analysis in gastric cancer.
Author:	Shen, Xiao-bing\|Wang, Jia\|Li, Peng-fei\|Ren, Xiao-feng\|Yan, Xiao-luan\|Wang, Fan
PMID:	25245011

71.
Journal:	World J Gastroenterol. 2014 Aug 28;20(32):11429-38.
Title:	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility.
Author:	Xia, Lei-Zhou\|Liu, Yi\|Xu, Xiao-Zhou\|Jiang, Peng-Cheng\|Ma, Gui\|Bu, Xue-Feng\|Zhang, Yong-Jun\|Yu, Feng\|Xu, Ke-Sen\|Li, Hua
PMID:	25170232

72.
Journal:	Mol Biol Rep. 2014 Jul;41(7):4659-73.
Title:	The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.
Author:	Tang, Min\|Wang, Shang-Qian\|Liu, Bian-Jiang\|Cao, Qiang\|Li, Bing-Jie\|Li, Peng-Chao\|Li, Yong-Fei\|Qin, Chao\|Zhang, Wei
PMID:	24744129

73.
Journal:	Mol Biol Rep. 2014 Jun;41(6):3637-50.
Title:	Susceptibility to Helicobacter pylori infection: results of an epidemiological investigation among gastric cancer patients.
Author:	Panic, Nikola\|Mastrostefano, Elena\|Leoncini, Emanuele\|Persiani, Roberto\|Arzani, Dario\|Amore, Rosarita\|Ricci, Riccardo\|Sicoli, Federico\|Sioletic, Stefano\|Bulajic, Milutin\|D' Ugo, Domenico\|Ricciardi, Walter\|Boccia, Stefania
PMID:	24526578

74.
Journal:	BMC Cancer. 2014 Feb 3;14:58.
Title:	A retrospective comparative exploratory study on two methylentetrahydrofolate reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patient
Author:	Blank, Susanne\|Rachakonda, Sivaramakrishna\|Keller, Gisela\|Weichert, Wilko\|Lordick, Florian\|Langer, Rupert\|Springfeld, Christoph\|Bruckner, Thomas\|Becker, Karen\|Kumar, Rajiv\|Ott, Katja
PMID:	24490800

75.
Journal:	Tumour Biol. 2014 Mar;35(3):2123-32.
Title:	MTHFR C677T polymorphism contributes to the risk for gastric cancer.
Author:	Yan, Shushan\|Xu, Donghua\|Wang, Pingping\|Wang, Ping\|Liu, Chengcheng\|Hua, Changjiang\|Jiang, Tao\|Zhang, Bin\|Li, Zengcai\|Lu, Lei\|Liu, Xianzhong\|Wang, Bingji\|Zhang, Donghua\|Zhang, Rongsheng\|He, Shaoheng\|Sun, Beicheng\|Wang, Xuan
PMID:	24122207

76.
Journal:	Tumour Biol. 2014 Jan;35(1):227-37.
Title:	The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C contributes to gastric cancer.
Author:	Lv, Long\|Wang, Ping\|Sun, Beicheng\|Chen, Gong
PMID:	23897558

77.
Journal:	Genet Mol Res. 2014 Mar 24;13(1):2060-8.
Title:	Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer.
Author:	Lin, J\|Zeng, R M\|Li, R N\|Cao, W H
PMID:	24737431

78.
Journal:	Oncol Lett. 2015 Aug;10(2):1159-1165.
Title:	Association between the MTHFR C677T polymorphism and gastric cancer susceptibility: A meta-analysis of 5,757 cases and 8,501 controls.
Author:	Chen, Long\|Lu, Ning\|Zhang, Bai-Hong\|Weng, L I\|Lu, Jun
PMID:	26622644

79.
Journal:	Med Sci Monit. 2015 Oct 12;21:3068-76.
Title:	MTHFR C677T Polymorphism is Associated with Tumor Response to Preoperative Chemoradiotherapy: A Result Based on Previous Reports.
Author:	Zhao, Yue\|Li, Xingde\|Kong, Xiangjun
PMID:	26456456

80.
Journal:	Genet Mol Res. 2015 Aug 21;14(3):10001-6.
Title:	Thymidylate synthase and methylenetetrahy-drofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil.
Author:	Araujo, M D\|Borges, B N\|Rodrigues-Antunes, S\|Burbano, R M R\|Harada, M L
PMID:	26345936

81.
Journal:	Tumour Biol. 2015 Nov;36(11):8953-72.
Title:	Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Author:	Xie, Shu-Zhe\|Liu, Zhi-Zhong\|Yu, Jun-hua\|Liu, Li\|Wang, Wei\|Xie, Dao-Lin\|Qin, Jiang-Bo
PMID:	26081619

82.
Journal:	Cell Physiol Biochem. 2015;36(2):622-30.
Title:	A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population.
Author:	Chen, Qiaoyun\|Qin, Rong\|Fang, Yue\|Li, Hao\|Liu, Yangchen
PMID:	25998065

83.
Journal:	Oncotarget. 2015 Apr 20;6(11):9564-76.
Title:	Polymorphism in one-carbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study.
Author:	Zhao, Tingting\|Gu, Dongying\|Xu, Zhi\|Huo, Xinying\|Shen, Lili\|Wang, Chun\|Tang, Yongfei\|Wu, Peng\|He, Jason\|Gong, Weida\|He, Ming-Liang\|Chen, Jinfei
PMID:	25840420

84.
Journal:	Tumour Biol. 2016 Feb;37(2):1753-62.
Title:	Influences of ERCC1, ERCC2, XRCC1, GSTP1, GSTT1, and MTHFR polymorphisms on clinical outcomes in gastric cancer patients treated with EOF chemotherapy.
Author:	Liu, Rujiao\|Zhao, Xiaoying\|Liu, Xin\|Chen, Zhiyu\|Qiu, Lixin\|Geng, Ruixuan\|Guo, Weijian\|He, Guang\|Yin, Jiliang\|Li, Jin\|Zhu, Xiaodong
PMID:	26314858

85.
Journal:	Mol Nutr Food Res. 2016 Feb;60(2):337-45.
Title:	Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea.
Author:	Kim, Woori\|Woo, Hae Dong\|Lee, Jeonghee\|Choi, Il Ju\|Kim, Young Woo\|Sung, Joohon\|Kim, Jeongseon
PMID:	26833750

86.
Journal:	Cancer. 2016 May 1;122(9):1434-43.
Title:	Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study.
Author:	Meulendijks, Didier\|de Groot, Jan Willem B\|Los, Maartje\|Boers, James E\|Beerepoot, Laurens V\|Polee, Marco B\|Beeker, Aart\|Portielje, Johanna E A\|Goey, Swan H\|de Jong, Robert S\|Vanhoutvin, Steven A L W\|Kuiper, Maria\|Sikorska, Karolina\|Pluim, Dick\|Beijnen, Jo
PMID:	26970343

87.
Journal:	Medicine (Baltimore). 2016 May;95(20):e3700.
Title:	Evaluation of an Association of Blood Homocysteine Levels With Gastric Cancer Risk From 27 Case-Control Studies.
Author:	Xu, Wei\|Cheng, Yuelei\|Zhu, Huirong
PMID:	27196483

88.
Journal:	Sci Rep. 2016 Jul 26;6:28019.
Title:	The effects of genomic polymorphisms in one-carbon metabolism pathways on survival of gastric cancer patients received fluorouracil-based adjuvant therapy.
Author:	Zhao, Tingting\|Xu, Zhi\|Gu, Dongying\|Wu, Peng\|Huo, Xinying\|Wei, Xiaowei\|Tang, Yongfei\|Gong, Weida\|He, Ming-Liang\|Chen, Jinfei
PMID:	27456431

89.
Journal:	Oncotarget. 2016 Aug 23;7(34):55449-55457.
Title:	ABCC2-24C > T polymorphism is associated with the response to platinum/5-Fu-based neoadjuvant chemotherapy and better clinical outcomes in advanced gastric cancer patients.
Author:	Li, Ziyu\|Xing, Xiaofang\|Shan, Fei\|Li, Shuangxi\|Li, Zhongwu\|Xiao, Aitang\|Xing, Zhaodong\|Xue, Kan\|Li, Zhemin\|Hu, Ying\|Jia, Yongning\|Miao, Rulin\|Zhang, Lianhai\|Bu, Zhaode\|Wu, Aiwen\|Ji, Jiafu
PMID:	27487151

90.
Journal:	Crit Rev Oncol Hematol. 2016 Nov;107:72-81.
Title:	Involvement of genetic factors and lifestyle on the occurrence of colorectal and gastric cancer.
Author:	Baroudi, Olfa\|Benammar-Elgaaied, Amel
PMID:	27823653

91.
Journal:	Pharmacogenomics J. 2017 Oct;17(5):441-451.
Title:	Pharmacogenetic variants associated with outcome in patients with advanced gastric cancer treated with fluoropyrimidine and platinum-based triplet combinations: a pooled analysis of three prospective studies.
Author:	Meulendijks, D\|Rozeman, E A\|Cats, A\|Sikorska, K\|Joerger, M\|Deenen, M J\|Beijnen, J H\|Schellens, J H M
PMID:	27995989

92.
Journal:	J Cancer. 2018 Feb 28;9(6):1057-1066.
Title:	A Meta-Analysis: Methylenetetrahydrofolate Reductase C677T Polymorphism in Gastric Cancer Patients Treated with 5-Fu Based Chemotherapy Predicts Serious Hematologic Toxicity but Not Prognosis.
Author:	Tang, Cheng\|Yu, Shan\|Jiang, Huiqin\|Li, Wei\|Xu, Xiaojing\|Cheng, Xi\|Peng, Ke\|Chen, Erbao\|Cui, Yuehong\|Liu, Tianshu
PMID:	29581785