Literatures

Primary Site >> Colorectal Cancer

Gene >> MTHFR

1.
Journal:	Cancer Res. 1996 Nov 1;56(21):4862-4.
Title:	A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
Author:	Chen, J\|Giovannucci, E\|Kelsey, K\|Rimm, E B\|Stampfer, M J\|Colditz, G A\|Spiegelman, D\|Willett, W C\|Hunter, D J
PMID:	8895734

2.
Journal:	Cancer Res. 1997 Mar 15;57(6):1098-102.
Title:	Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
Author:	Ma, J\|Stampfer, M J\|Giovannucci, E\|Artigas, C\|Hunter, D J\|Fuchs, C\|Willett, W C\|Selhub, J\|Hennekens, C H\|Rozen, R
PMID:	9067278

3.
Journal:	Mamm Genome. 1998 Aug;9(8):652-6.
Title:	Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
Author:	Goyette, P\|Pai, A\|Milos, R\|Frosst, P\|Tran, P\|Chen, Z\|Chan, M\|Rozen, R
PMID:	9680386

4.
Journal:	Carcinogenesis. 1998 Dec;19(12):2129-32.
Title:	A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
Author:	Chen, J\|Giovannucci, E\|Hankinson, S E\|Ma, J\|Willett, W C\|Spiegelman, D\|Kelsey, K T\|Hunter, D J
PMID:	9886567

5.
Journal:	J Nutr. 1999 Feb;129(2S Suppl):560S-564S.
Title:	MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis.
Author:	Chen, J\|Giovannucci, E L\|Hunter, D J
PMID:	10064332

6.
Journal:	Oncol Rep. 1999 May-Jun;6(3):597-9.
Title:	Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas.
Author:	Pereira, P\|Stanton, V\|Jothy, S\|Tomlinson, I P\|Foulkes, W D\|Rozen, R
PMID:	10203598

7.
Journal:	J Natl Cancer Inst. 1999 Jun 2;91(11):916-32.
Title:	Colorectal cancer: molecules and populations.
Author:	Potter, J D
PMID:	10359544

8.
Journal:	Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):513-8.
Title:	Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.
Author:	Slattery, M L\|Potter, J D\|Samowitz, W\|Schaffer, D\|Leppert, M
PMID:	10385141

9.
Journal:	Genet Test. 1999;3(2):233-6.
Title:	The 677C > T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk.
Author:	Park, K S\|Mok, J W\|Kim, J C
PMID:	10464674

10.
Journal:	Cancer Epidemiol Biomarkers Prev. 1999 Sep;8(9):825-9.
Title:	A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk.
Author:	Ma, J\|Stampfer, M J\|Christensen, B\|Giovannucci, E\|Hunter, D J\|Chen, J\|Willett, W C\|Selhub, J\|Hennekens, C H\|Gravel, R\|Rozen, R
PMID:	10498402

11.
Journal:	J Investig Med. 2000 Jan;48(1):14-20.
Title:	The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T).
Author:	Lalouschek, W\|Aull, S\|Serles, W\|Wolfsberger, M\|Deecke, L\|Pabinger-Fasching, I\|Mannhalter, C
PMID:	10695265

12.
Journal:	Cancer Lett. 2000 Apr 14;151(2):181-6.
Title:	Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas.
Author:	Marugame, T\|Tsuji, E\|Inoue, H\|Shinomiya, S\|Kiyohara, C\|Onuma, K\|Hamada, H\|Koga, H\|Handa, K\|Hayabuchi, H\|Kono, S
PMID:	10738112

13.
Journal:	Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):427-33.
Title:	Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps.
Author:	Ulrich, C M\|Kampman, E\|Bigler, J\|Schwartz, S M\|Chen, C\|Bostick, R\|Fosdick, L\|Beresford, S A\|Yasui, Y\|Potter, J D
PMID:	10794488

14.
Journal:	J Epidemiol. 2000 Sep;10(5):349-60.
Title:	Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer.
Author:	Kiyohara, C
PMID:	11059519

15.
Journal:	Cancer Causes Control. 2000 Oct;11(9):799-803.
Title:	Associations between family history of cancer and genes coding for metabolizing enzymes (United States).
Author:	Slattery, M L\|Edwards, S L\|Samowitz, W\|Potter, J
PMID:	11075868

16.
Journal:	Stat Med. 2000 Dec 30;19(24):3449-64.
Title:	Sequential analysis of matched dichotomous data from prospective case-control studies.
Author:	Van der Tweel, I\|van Noord, P A
PMID:	11122507

17.
Journal:	Curr Oncol Rep. 2000 May;2(3):225-33.
Title:	Diet and prevention of colorectal cancer.
Author:	Ritenbaugh, C
PMID:	11122847

18.
Journal:	Leuk Lymphoma. 2000 Nov;39(5-6):607-12.
Title:	Normal frequencies of the C677T genotypes on the methylenetetrahydrofolate reductase (MTHFR) gene among lymphoproliferative disorders but not in multiple myeloma.
Author:	Gonzalez Ordonez, A J\|Fernandez Carreira, J M\|Fernandez Alvarez, C R\|Martin, L\|Sanchez Garcia, J\|Medina Rodriguez, J M\|Alvarez, M V\|Coto, E
PMID:	11342344

19.
Journal:	Hum Mol Genet. 2001 Mar 1;10(5):433-43.
Title:	Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Author:	Chen, Z\|Karaplis, A C\|Ackerman, S L\|Pogribny, I P\|Melnyk, S\|Lussier-Cacan, S\|Chen, M F\|Pai, A\|John, S W\|Smith, R S\|Bottiglieri, T\|Bagley, P\|Selhub, J\|Rudnicki, M A\|James, S J\|Rozen, R
PMID:	11181567

20.
Journal:	Carcinogenesis. 2001 Jul;22(7):1019-25.
Title:	Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro.
Author:	Crott, J W\|Mashiyama, S T\|Ames, B N\|Fenech, M F
PMID:	11408344

21.
Journal:	Rev Gastroenterol Mex. 2001 Jan-Mar;66(1):32-7.
Title:	[677T mutation of the MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results].
Author:	Delgado-Enciso, I\|Martinez-Garza, S G\|Rojas-Martinez, A\|Ortiz-Lopez, R\|Bosques-Padilla, F\|Calderon-Garciduenas, A L\|Zarate-Gomez, M\|Barrera-Saldana, H A
PMID:	11464627

22.
Journal:	Gastroenterology. 2001 Aug;121(2):282-301.
Title:	Polymorphisms and colorectal tumor risk.
Author:	Houlston, R S\|Tomlinson, I P
PMID:	11487538

23.
Journal:	J Lab Clin Med. 2001 Sep;138(3):164-76.
Title:	Relevance of folate metabolism in the pathogenesis of colorectal cancer.
Author:	Ryan, B M\|Weir, D G
PMID:	11528369

24.
Journal:	Swiss Med Wkly. 2001 Sep 22;131(37-38):539-49.
Title:	Folate and the risk of colorectal, breast and cervix cancer: the epidemiological evidence.
Author:	Eichholzer, M\|Luthy, J\|Moser, U\|Fowler, B
PMID:	11759174

25.
Journal:	Kongressbd Dtsch Ges Chir Kongr. 2001;118:820-4.
Title:	[Can molecular genetic knowledge from studies of hereditary carcinoma be applied to sporadic colorectal carcinoma?].
Author:	Pistorius, S\|Schackert, H K\|Saeger, H D
PMID:	11824368

26.
Journal:	Int J Gastrointest Cancer. 2001;30(3):105-11.
Title:	The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression.
Author:	Ryan, B M\|Molloy, A M\|McManus, R\|Arfin, Q\|Kelleher, D\|Scott, J M\|Weir, D G
PMID:	12540022

27.
Journal:	Am J Hum Genet. 2002 Mar;70(3):758-62. Epub 2002 Jan 4.
Title:	The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans.
Author:	Rosenberg, Nurit\|Murata, Mitsuru\|Ikeda, Yasuo\|Opare-Sem, Ohene\|Zivelin, Ariella\|Geffen, Eli\|Seligsohn, Uri
PMID:	11781870

28.
Journal:	Gut. 2002 Apr;50(4):520-4.
Title:	A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability.
Author:	Shannon, B\|Gnanasampanthan, S\|Beilby, J\|Iacopetta, B
PMID:	11889073

29.
Journal:	Cancer Causes Control. 2002 Apr;13(3):239-48.
Title:	B-vitamin intake, metabolic genes, and colorectal cancer risk (United States).
Author:	Le Marchand, Loic\|Donlon, Timothy\|Hankin, Jean H\|Kolonel, Laurence N\|Wilkens, Lynne R\|Seifried, Ann
PMID:	12020105

30.
Journal:	Pharmacogenetics. 2002 Jun;12(4):339-42.
Title:	Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer.
Author:	Chen, Jia\|Ma, Jing\|Stampfer, Meir J\|Palomeque, Caroline\|Selhub, Jacob\|Hunter, David J
PMID:	12042673

31.
Journal:	Br J Cancer. 2002 Jul 15;87(2):225-30.
Title:	Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines.
Author:	Sekhon, J\|Pereira, P\|Sabbaghian, N\|Schievella, A R\|Rozen, R
PMID:	12107847

32.
Journal:	J Nutr. 2002 Aug;132(8 Suppl):2350S-2355S.
Title:	Epidemiologic studies of folate and colorectal neoplasia: a review.
Author:	Giovannucci, Edward
PMID:	12163691

33.
Journal:	J Nutr. 2002 Aug;132(8 Suppl):2413S-2418S.
Title:	Folate status: effects on pathways of colorectal carcinogenesis.
Author:	Choi, Sang-Woon\|Mason, Joel B
PMID:	12163703

34.
Journal:	Carcinogenesis. 2002 Nov;23(11):1839-49.
Title:	A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Author:	Sachse, Christoph\|Smith, Gillian\|Wilkie, Murray J V\|Barrett, Jennifer H\|Waxman, Robin\|Sullivan, Frank\|Forman, David\|Bishop, D Timothy\|Wolf, C Roland
PMID:	12419832

35.
Journal:	Cancer Lett. 2002 Jul 8;181(1):65-71.
Title:	Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR).
Author:	Sharp, L\|Little, J\|Schofield, A C\|Pavlidou, E\|Cotton, S C\|Miedzybrodzka, Z\|Baird, J O C\|Haites, N E\|Heys, S D\|Grubb, D A
PMID:	12430180

36.
Journal:	Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1332-52.
Title:	Low-penetrance genes and their involvement in colorectal cancer susceptibility.
Author:	de Jong, Mirjam M\|Nolte, Ilja M\|te Meerman, Gerard J\|van der Graaf, Winette T A\|de Vries, Elisabeth G E\|Sijmons, Rolf H\|Hofstra, Robert M W\|Kleibeuker, Jan H
PMID:	12433710

37.
Journal:	Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1611-21.
Title:	5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.
Author:	Keku, Temitope\|Millikan, Robert\|Worley, Kendra\|Winkel, Scott\|Eaton, Allison\|Biscocho, Lorna\|Martin, Christopher\|Sandler, Robert
PMID:	12496052

38.
Journal:	Asian Pac J Cancer Prev. 2002;3(4):353-359.
Title:	Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer.
Author:	Matsuo, Keitaro\|Hamajima, Nobuyuki\|Hirai, Takashi\|Kato, Tomoyuki\|Inoue, Manami\|Takezaki, Toshiro\|Tajima, Kazuo
PMID:	12716294

39.
Journal:	Am J Prev Med. 2003 Feb;24(2):170-6.
Title:	Family history of colon cancer: what does it mean and how is it useful?
Author:	Keku, Temitope O\|Millikan, Robert C\|Martin, Chris\|Rahkra-Burris, Tejinder K\|Sandler, Robert S
PMID:	12568823

40.
Journal:	Clin Cancer Res. 2003 Feb;9(2):743-8.
Title:	Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
Author:	Toffoli, Giuseppe\|Gafa, Roberta\|Russo, Antonio\|Lanza, Giovanni\|Dolcetti, Riccardo\|Sartor, Franca\|Libra, Massimo\|Viel, Alessandra\|Boiocchi, Mauro
PMID:	12576444

41.
Journal:	Cancer Lett. 2003 Mar 10;191(2):179-85.
Title:	Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability.
Author:	Plaschke, Jens\|Schwanebeck, Uta\|Pistorius, Steffen\|Saeger, Hans D\|Schackert, Hans K
PMID:	12618331

42.
Journal:	Gastroenterology. 2003 May;124(5):1240-8.
Title:	Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study.
Author:	Pufulete, Maria\|Al-Ghnaniem, Reyad\|Leather, Andrew J M\|Appleby, Paul\|Gout, Sally\|Terry, Catherine\|Emery, Peter W\|Sanders, Thomas A B
PMID:	12730865

43.
Journal:	Clin Cancer Res. 2003 May;9(5):1611-5.
Title:	Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy.
Author:	Cohen, Victor\|Panet-Raymond, Valerie\|Sabbaghian, Nelly\|Morin, Isabelle\|Batist, Gerald\|Rozen, Rima
PMID:	12738713

44.
Journal:	Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):970-9.
Title:	Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas.
Author:	Giovannucci, Edward\|Chen, Jia\|Smith-Warner, Stephanie A\|Rimm, Eric B\|Fuchs, Charles S\|Palomeque, Caroline\|Willett, Walter C\|Hunter, David J
PMID:	14578131

45.
Journal:	J Nutr. 2003 Nov;133(11 Suppl 1):3748S-3753S.
Title:	Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations.
Author:	Bailey, Lynn B
PMID:	14608109

46.
Journal:	J Nutr. 2003 Nov;133(11 Suppl 1):3758S-3766S.
Title:	Colon cancer and genetic variation in folate metabolism: the clinical bottom line.
Author:	Little, Julian\|Sharp, Linda\|Duthie, Susan\|Narayanan, Sabrina
PMID:	14608111

47.
Journal:	Hematology Am Soc Hematol Educ Program. 2003:62-81.
Title:	Update on cobalamin, folate, and homocysteine.
Author:	Carmel, Ralph\|Green, Ralph\|Rosenblatt, David S\|Watkins, David
PMID:	14633777

48.
Journal:	Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5860-5.
Title:	The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase.
Author:	Kawakami, Kazuyuki\|Ruszkiewicz, Andrew\|Bennett, Graeme\|Moore, James\|Watanabe, Go\|Iacopetta, Barry
PMID:	14676107

49.
Journal:	Gut. 2004 Feb;53(2):271-6.
Title:	Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.
Author:	Crabtree, M D\|Fletcher, C\|Churchman, M\|Hodgson, S V\|Neale, K\|Phillips, R K S\|Tomlinson, I P M
PMID:	14724163

50.
Journal:	Eur J Cancer. 2004 Mar;40(4):508-14.
Title:	Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer.
Author:	Veronese, M L\|Stevenson, J P\|Sun, W\|Redlinger, M\|Algazy, K\|Giantonio, B\|Hahn, S\|Vaughn, D\|Thorn, C\|Whitehead, A S\|Haller, D G\|O'Dwyer, P J
PMID:	14962716

51.
Journal:	Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):285-92.
Title:	MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer.
Author:	Curtin, Karen\|Bigler, Jeannette\|Slattery, Martha L\|Caan, Bette\|Potter, John D\|Ulrich, Cornelia M
PMID:	14973104

52.
Journal:	Am J Epidemiol. 2004 Mar 1;159(5):423-43.
Title:	Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
Author:	Sharp, Linda\|Little, Julian
PMID:	14977639

53.
Journal:	Carcinogenesis. 2004 Aug;25(8):1443-8.
Title:	The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.
Author:	Saffroy, Raphael\|Pham, Patrick\|Chiappini, Franck\|Gross-Goupil, Marine\|Castera, Laurent\|Azoulay, Daniel\|Barrier, Alain\|Samuel, Didier\|Debuire, Brigitte\|Lemoine, Antoinette
PMID:	15033905

54.
Journal:	Anticancer Res. 2004 Mar-Apr;24(2B):649-54.
Title:	The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.
Author:	Oyama, Kaeko\|Kawakami, Kazuyuki\|Maeda, Kazuya\|Ishiguro, Kaname\|Watanabe, Go
PMID:	15161007

55.
Journal:	Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Jul;25(7):612-6.
Title:	[A case-control study on the polymorphisms of methylenetetrahydrofolate reductases, drinking interaction and susceptibility in colorectal cancer].
Author:	Jiang, Qin-ting\|Chen, Kun\|Ma, Xin-yuan\|Miao, Xiao-ping\|Yao, Kai-yan\|Yu, Wei-ping\|Li, Ling-yun\|Zhu, Yi-min\|Zhou, Hai-guang
PMID:	15308044

56.
Journal:	Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1436-43.
Title:	Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo.
Author:	Narayanan, Sabrina\|McConnell, Josie\|Little, Julian\|Sharp, Linda\|Piyathilake, Chandrika J\|Powers, Hilary\|Basten, Graham\|Duthie, Susan J
PMID:	15342443

57.
Journal:	Am J Clin Nutr. 2004 Oct;80(4):1050-7.
Title:	Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction.
Author:	Hustad, Steinar\|Nedrebo, Bjorn G\|Ueland, Per Magne\|Schneede, Jorn\|Vollset, Stein Emil\|Ulvik, Arve\|Lien, Ernst A
PMID:	15447919

58.
Journal:	Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Sep;33(5):465-8.
Title:	[Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer risk: a human genomic epidemiologic review].
Author:	Jin, Ming-juan\|Chen, Kun
PMID:	15476336

59.
Journal:	Magy Onkol. 2004;48(3):253-7. Epub 2004 Nov 1.
Title:	[The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours].
Author:	Budai, Barna\|Hitre, Erika\|Adleff, Vilmos\|Czegledi, Ferenc\|Gyergyay, Fruzsina\|Lang, Istvan\|Kralovanszky, Judit
PMID:	15520876

60.
Journal:	Cancer Lett. 2004 Dec 28;216(2):199-205.
Title:	Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea.
Author:	Kim, Dong-Hyun\|Ahn, Yoon-Ok\|Lee, Bong-Hwa\|Tsuji, Emiko\|Kiyohara, Chikako\|Kono, Suminori
PMID:	15533596

61.
Journal:	Cancer Sci. 2004 Nov;95(11):908-13.
Title:	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study.
Author:	Yin, Guang\|Kono, Suminori\|Toyomura, Kengo\|Hagiwara, Tomoko\|Nagano, Jun\|Mizoue, Tetsuya\|Mibu, Ryuichi\|Tanaka, Masao\|Kakeji, Yoshihiro\|Maehara, Yoshihiko\|Okamura, Takeshi\|Ikejiri, Koji\|Futami, Kitaroh\|Yasunami, Yohichi\|Maekawa, Takafumi\|Takenaka, Kenji\|Ichi
PMID:	15546509

62.
Journal:	Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2175-80.
Title:	Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort.
Author:	Ulvik, Arve\|Vollset, Stein Emil\|Hansen, Svein\|Gislefoss, Randi\|Jellum, Egil\|Ueland, Per Magne
PMID:	15598777

63.
Journal:	Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2247-50.
Title:	Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas.
Author:	Chen, Jia\|Kyte, Charles\|Chan, Wendy\|Wetmur, James G\|Fuchs, Charles S\|Giovannucci, Edward
PMID:	15598787

64.
Journal:	Pharmacogenetics. 2004 Dec;14(12):785-92.
Title:	Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.
Author:	Etienne, Marie-Christine\|Formento, Jean-Louis\|Chazal, Maurice\|Francoual, Mireille\|Magne, Nicolas\|Formento, Patricia\|Bourgeon, Andre\|Seitz, Jean-Francois\|Delpero, Jean-Robert\|Letoublon, Christian\|Pezet, Denis\|Milano, Gerard
PMID:	15608557

65.
Journal:	Cancer Res Treat. 2004 Apr;36(2):93-9.
Title:	Molecular epidemiology of colon cancer.
Author:	Kim, Dong-Hyun\|Ahn, Yoon-Ok
PMID:	20396547

66.
Journal:	Int J Cancer. 2005 Mar 10;114(1):58-73.
Title:	Genotype phenotype correlations in Israeli colorectal cancer patients.
Author:	Starinsky, Sigal\|Figer, Arie\|Ben-Asher, Edna\|Geva, Ravit\|Flex, Dov\|Fidder, Herma H\|Zidan, Jamal\|Lancet, Doron\|Friedman, Eitan
PMID:	15523694

67.
Journal:	World J Gastroenterol. 2005 Jan 21;11(3):331-5.
Title:	Relationship between metabolic enzyme polymorphism and colorectal cancer.
Author:	Chen, Kun\|Jiang, Qin-Ting\|He, Han-Qing
PMID:	15637738

68.
Journal:	Br J Cancer. 2005 Mar 14;92(5):838-42.
Title:	Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer.
Author:	Pufulete, M\|Al-Ghnaniem, R\|Rennie, J A\|Appleby, P\|Harris, N\|Gout, S\|Emery, P W\|Sanders, T A
PMID:	15726099

69.
Journal:	Clin Cancer Res. 2005 Mar 1;11(5):2047-52.
Title:	Antisense inhibition of methylenetetrahydrofolate reductase reduces cancer cell survival in vitro and tumor growth in vivo.
Author:	Stankova, Jitka\|Shang, Jijun\|Rozen, Rima
PMID:	15756031

70.
Journal:	Cancer Detect Prev. 2005;29(2):146-54.
Title:	Diets, polymorphisms of methylenetetrahydrofolate reductase, and the susceptibility of colon cancer and rectal cancer.
Author:	Jiang, Qinting\|Chen, Kun\|Ma, Xinyuan\|Li, Qilong\|Yu, Weiping\|Shu, Guotong\|Yao, Kaiyan
PMID:	15829374

71.
Journal:	Int J Oncol. 2005 Jun;26(6):1449-64.
Title:	Folic acid and colorectal cancer prevention: molecular mechanisms and epidemiological evidence (Review).
Author:	Strohle, Alexander\|Wolters, Maike\|Hahn, Andreas
PMID:	15870856

72.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1198-203.
Title:	The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study.
Author:	Le Marchand, Loic\|Wilkens, Lynne R\|Kolonel, Laurence N\|Henderson, Brian E
PMID:	15894672

73.
Journal:	Magy Onkol. 2005;49(1):3-7. Epub 2005 May 18.
Title:	[Activity of the National Oncology R&D Consortium in 2004].
Author:	Timar, Jozsef
PMID:	15902326

74.
Journal:	Pharmacogenet Genomics. 2005 Aug;15(8):535-46.
Title:	A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
Author:	Landi, Stefano\|Gemignani, Federica\|Moreno, Victor\|Gioia-Patricola, Lydie\|Chabrier, Amelie\|Guino, Elisabeth\|Navarro, Matilde\|de Oca, Javier\|Capella, Gabriel\|Canzian, Federico
PMID:	16006997

75.
Journal:	Korean J Gastroenterol. 2005 Jul;46(1):32-8.
Title:	[Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer].
Author:	Lee, Jun\|Jeong, Cheol Kweon\|Hong, Sung Pyo\|Chong, So Young\|Oh, Doyeun\|Hwang, Seong Gyu\|Ahn, Dae Ho\|Kim, Sehyun\|Han, Jin Hee\|Kim, Nam Keun
PMID:	16030402

76.
Journal:	Carcinogenesis. 2005 Dec;26(12):2164-71.
Title:	One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan.
Author:	Matsuo, Keitaro\|Ito, Hidemi\|Wakai, Kenji\|Hirose, Kaoru\|Saito, Toshiko\|Suzuki, Takeshi\|Kato, Tomoyuki\|Hirai, Takashi\|Kanemitsu, Yukihide\|Hamajima, Hiroshi\|Tajima, Kazuo
PMID:	16051637

77.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2023-9.
Title:	5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.
Author:	Eaton, Allison M\|Sandler, Robert\|Carethers, John M\|Millikan, Robert C\|Galanko, Joseph\|Keku, Temitope O
PMID:	16103455

78.
Journal:	Cancer Sci. 2005 Sep;96(9):535-42.
Title:	Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma.
Author:	Kono, Suminori\|Chen, Kun
PMID:	16128738

79.
Journal:	J Nutr. 2005 Oct;135(10):2462-7.
Title:	MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors.
Author:	Ulrich, C M\|Curtin, K\|Samowitz, W\|Bigler, J\|Potter, J D\|Caan, B\|Slattery, M L
PMID:	16177213

80.
Journal:	Int J Hyg Environ Health. 2005;208(5):321-7.
Title:	Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study.
Author:	Karagas, Margaret R\|Park, Sunyeong\|Nelson, Heather H\|Andrew, Angeline S\|Mott, Leila\|Schned, Alan\|Kelsey, Karl T
PMID:	16217917

81.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2509-16.
Title:	Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
Author:	Ulrich, Cornelia M\|Curtin, Karen\|Potter, John D\|Bigler, Jeannette\|Caan, Bette\|Slattery, Martha L
PMID:	16284371

82.
Journal:	J Nutr. 2005 Dec;135(12 Suppl):2960S-2966S.
Title:	Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer.
Author:	Powers, Hilary J
PMID:	16317155

83.
Journal:	Zhonghua Yu Fang Yi Xue Za Zhi. 2005 Nov;39(6):409-11.
Title:	[Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population].
Author:	Miao, Xiao-ping\|Yang, Shen\|Tan, Wen\|Zhang, Xue-mei\|Ye, Ying-jiang\|Lin, Dong-xin\|Wang, Shan
PMID:	16329804

84.
Journal:	Nutr Cancer. 2005;53(1):42-50.
Title:	Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan.
Author:	Otani, Tetsuya\|Iwasaki, Motoki\|Hanaoka, Tomoyuki\|Kobayashi, Minatsu\|Ishihara, Junko\|Natsukawa, Syusuke\|Shaura, Kozo\|Koizumi, Yoichi\|Kasuga, Yoshio\|Yoshimura, Kimio\|Yoshida, Teruhiko\|Tsugane, Shoichiro
PMID:	16351505

85.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2999-3003.
Title:	Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes.
Author:	Lightfoot, Tracy J\|Skibola, Christine F\|Willett, Eleanor V\|Skibola, Danica R\|Allan, James M\|Coppede, Fabio\|Adamson, Peter J\|Morgan, Gareth J\|Roman, Eve\|Smith, Martyn T
PMID:	16365025

86.
Journal:	Int J Cancer. 2006 Feb 15;118(4):991-7.
Title:	Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population.
Author:	Wang, Jingwen\|Gajalakshmi, Vendhan\|Jiang, Jing\|Kuriki, Kiyonori\|Suzuki, Sadao\|Nagaya, Teruo\|Nakamura, Seiichi\|Akasaka, Susumu\|Ishikawa, Hideki\|Tokudome, Shinkan
PMID:	16152599

87.
Journal:	Cancer Chemother Pharmacol. 2006 Jun;57(6):835-40. Epub 2005 Sep 27.
Title:	Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy?
Author:	Marcuello, E\|Altes, A\|Menoyo, A\|Rio, E Del\|Baiget, M
PMID:	16187112

88.
Journal:	Br J Cancer. 2006 Feb 27;94(4):593-8.
Title:	DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer.
Author:	Kawakami, K\|Ruszkiewicz, A\|Bennett, G\|Moore, J\|Grieu, F\|Watanabe, G\|Iacopetta, B
PMID:	16421593

89.
Journal:	Cancer. 2006 Mar 1;106(5):1007-16.
Title:	Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Author:	Massacesi, Cristian\|Terrazzino, Salvatore\|Marcucci, Fabiana\|Rocchi, Marco B\|Lippe, Paolo\|Bisonni, Renato\|Lombardo, Marco\|Pilone, Alberta\|Mattioli, Rodolfo\|Leon, Alberta
PMID:	16456808

90.
Journal:	Clin Colorectal Cancer. 2006 Jan;5(5):344-9.
Title:	Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer.
Author:	Odin, Elisabeth\|Wettergren, Yvonne\|Carlsson, Goran\|Danenberg, Peter V\|Termini, Angelo\|Willen, Roger\|Gustavsson, Bengt
PMID:	16512993

91.
Journal:	Gut. 2006 Oct;55(10):1461-6.
Title:	Low folate levels may protect against colorectal cancer.
Author:	Van Guelpen, B\|Hultdin, J\|Johansson, I\|Hallmans, G\|Stenling, R\|Riboli, E\|Winkvist, A\|Palmqvist, R
PMID:	16638790

92.
Journal:	Genet Mol Res. 2006 Jun 30;5(2):315-22.
Title:	Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer.
Author:	Clarizia, Alessandra D\|Bastos-Rodrigues, Luciana\|Pena, Heloisa B\|Anacleto, Charles\|Rossi, Benedito\|Soares, Fernando A\|Lopes, Ademar\|Rocha, Jose Claudio C\|Caballero, Otavia\|Camargo, Anamaria\|Simpson, Andrew J G\|Pena, Sergio D J
PMID:	16819711

93.
Journal:	J Int Med Res. 2006 May-Jun;34(3):307-15.
Title:	Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.
Author:	Takeda, R\|Kamano, T\|Sakamoto, K\|Sugano, M\|Hosoda, S\|Watanabe, T\|Maeda, T\|Kojima, Y
PMID:	16866026

94.
Journal:	Anticancer Res. 2006 Jul-Aug;26(4B):2879-81.
Title:	Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia.
Author:	Kim, Nam Keun\|Chong, So Young\|Jang, Moon Ju\|Hong, Seung Ho\|Kim, Heung Sik\|Cho, Eun Kyung\|Lee, Jung Ae\|Ahn, Myung Ju\|Kim, Chul Soo\|Oh, Doyeun
PMID:	16886608

95.
Journal:	Cancer Causes Control. 2006 Oct;17(8):1005-16.
Title:	Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate?
Author:	Brockton, N T
PMID:	16933051

96.
Journal:	Hum Mol Genet. 2006 Nov 1;15(21):3263-71.
Title:	Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.
Author:	Webb, Emily L\|Rudd, Matthew F\|Sellick, Gabrielle S\|El Galta, Rachid\|Bethke, Lara\|Wood, Wendy\|Fletcher, Olivia\|Penegar, Steven\|Withey, Laura\|Qureshi, Mobshra\|Johnson, Nichola\|Tomlinson, Ian\|Gray, Richard\|Peto, Julian\|Houlston, Richard S
PMID:	17000706

97.
Journal:	Ann Surg Oncol. 2006 Nov;13(11):1379-85. Epub 2006 Sep 29.
Title:	Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene?
Author:	Suh, Kwang Wook\|Kim, Joo Hyung\|Kim, Do Yoon\|Kim, Young Bae\|Lee, Chulho\|Choi, Sungho
PMID:	17009149

98.
Journal:	Pharmacogenet Genomics. 2006 Nov;16(11):817-24.
Title:	A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation.
Author:	Terrazzino, Salvatore\|Agostini, Marco\|Pucciarelli, Salvatore\|Pasetto, Lara Maria\|Friso, Maria Luisa\|Ambrosi, Alessandro\|Lisi, Veronica\|Leon, Alberta\|Lise, Mario\|Nitti, Donato
PMID:	17047490

99.
Journal:	Cancer Res. 2006 Nov 1;66(21):10349-56.
Title:	Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Author:	Knock, Erin\|Deng, Liyuan\|Wu, Qing\|Leclerc, Daniel\|Wang, Xiao-ling\|Rozen, Rima
PMID:	17079455

100.
Journal:	Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2408-17.
Title:	Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer.
Author:	Koushik, Anita\|Kraft, Peter\|Fuchs, Charles S\|Hankinson, Susan E\|Willett, Walter C\|Giovannucci, Edward L\|Hunter, David J
PMID:	17164363

101.
Journal:	Cell Biochem Funct. 2007 Jul-Aug;25(4):419-22.
Title:	Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer.
Author:	Zeybek, Umit\|Yaylim, Ilhan\|Yilmaz, Hulya\|Agachan, Bedia\|Ergen, Arzu\|Arikan, Soykan\|Bayrak, Savas\|Isbir, Turgay
PMID:	16927418

102.
Journal:	Int J Colorectal Dis. 2007 May;22(5):483-9. Epub 2006 Aug 29.
Title:	Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers.
Author:	Chang, Shih-Ching\|Lin, Pei-Ching\|Lin, Jen-Kou\|Yang, Shung-Haur\|Wang, Huann-Sheng\|Li, Anna Fen-Yau
PMID:	16941173

103.
Journal:	J Hum Genet. 2007;52(1):73-85. Epub 2006 Nov 7.
Title:	Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis.
Author:	Huang, Yan\|Han, Shizhong\|Li, Yao\|Mao, Yumin\|Xie, Yi
PMID:	17089070

104.
Journal:	Int J Colorectal Dis. 2007 Jul;22(7):757-63. Epub 2006 Nov 18.
Title:	Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma.
Author:	Lima, Carmen S P\|Nascimento, Helvia\|Bonadia, Luciana C\|Teori, Maria T\|Coy, Claudio S R\|Goes, Juvenal R N\|Costa, Fernando F\|Bertuzzo, Carmen S
PMID:	17111187

105.
Journal:	Int J Cancer. 2007 Mar 1;120(5):1027-35.
Title:	MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations.
Author:	Hubner, Richard A\|Houlston, Richard S
PMID:	17131337

106.
Journal:	Cancer Causes Control. 2007 Mar;18(2):153-63.
Title:	Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer.
Author:	Murtaugh, Maureen A\|Curtin, Karen\|Sweeney, Carol\|Wolff, Roger K\|Holubkov, Richard\|Caan, Bette J\|Slattery, Martha L
PMID:	17245555

107.
Journal:	Hum Mol Genet. 2007 May 1;16(9):1072-7. Epub 2007 Mar 9.
Title:	MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.
Author:	Hubner, Richard A\|Lubbe, Steven\|Chandler, Ian\|Houlston, Richard S
PMID:	17350979

108.
Journal:	Am J Gastroenterol. 2007 May;102(5):1108-15.
Title:	Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine.
Author:	Peyrin-Biroulet, Laurent\|Rodriguez-Gueant, Rosa-Maria\|Chamaillard, Mathias\|Desreumaux, Pierre\|Xia, Bing\|Bronowicki, Jean-Pierre\|Bigard, Marc-Andre\|Gueant, Jean-Louis
PMID:	17355415

109.
Journal:	Dig Dis Sci. 2007 Jun;52(6):1462-70.
Title:	Folate status and risk of colorectal polyps in African Americans.
Author:	Ashktorab, H\|Begum, R\|Akhgar, A\|Smoot, D T\|Elbedawi, M\|Daremipouran, M\|Zhao, A\|Momen, B\|Giardiello, F M
PMID:	17372834

110.
Journal:	Carcinogenesis. 2007 Aug;28(8):1672-9. Epub 2007 Apr 21.
Title:	Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet.
Author:	Curtin, Karen\|Slattery, Martha L\|Ulrich, Cornelia M\|Bigler, Jeannette\|Levin, Theodore R\|Wolff, Roger K\|Albertsen, Hans\|Potter, John D\|Samowitz, Wade S
PMID:	17449906

111.
Journal:	Anticancer Res. 2007 Mar-Apr;27(2):1151-6.
Title:	Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1.
Author:	Mas, Sergi\|Lafuente, M Jose\|Crescenti, Anna\|Trias, Manuel\|Ballesta, Antonio\|Molina, Rafael\|Zheng, Shichun\|Wiencke, John K\|Lafuente, Amalia
PMID:	17465256

112.
Journal:	Mutat Res. 2007 Sep 1;622(1-2):14-8. Epub 2007 May 21.
Title:	The interactive effect of methyl-group diet and polymorphism of methylenetetrahydrofolate reductase on the risk of colorectal cancer.
Author:	Kim, Dong-Hyun
PMID:	17602711

113.
Journal:	Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1753-9.
Title:	Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population.
Author:	Pande, Mala\|Chen, Jinyun\|Amos, Christopher I\|Lynch, Patrick M\|Broaddus, Russell\|Frazier, Marsha L
PMID:	17855693

114.
Journal:	J Gastrointestin Liver Dis. 2007 Sep;16(3):251-6.
Title:	MTHFR polymorphisms as prognostic factors in sporadic colorectal cancer.
Author:	Osian, Gelu\|Procopciuc, Lucia\|Vlad, Liviu
PMID:	17925917

115.
Journal:	Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2128-35.
Title:	Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).
Author:	Powers, Hilary J\|Hill, Marilyn H\|Welfare, Mark\|Spiers, Alison\|Bal, Wendy\|Russell, Jean\|Duckworth, Yvonne\|Gibney, Eileen\|Williams, Elizabeth A\|Mathers, John C
PMID:	17932361

116.
Journal:	Pharmacogenomics. 2007 Nov;8(11):1561-6.
Title:	Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer.
Author:	Etienne-Grimaldi, Marie-Christine\|Francoual, Mireille\|Formento, Jean-Louis\|Milano, Gerard
PMID:	18034621

117.
Journal:	Clin Colorectal Cancer. 2007 Nov;6(10):720-7.
Title:	Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels.
Author:	Odin, Elisabeth\|Wettergren, Yvonne\|Nilsson, Staffan\|Carlsson, Goran\|Gustavsson, Bengt
PMID:	18039426

118.
Journal:	Pharmacogenomics J. 2008 Aug;8(4):278-88.
Title:	Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy.
Author:	Ruzzo, A\|Graziano, F\|Loupakis, F\|Santini, D\|Catalano, V\|Bisonni, R\|Ficarelli, R\|Fontana, A\|Andreoni, F\|Falcone, A\|Canestrari, E\|Tonini, G\|Mari, D\|Lippe, P\|Pizzagalli, F\|Schiavon, G\|Alessandroni, P\|Giustini, L\|Maltese, P\|Testa, E\|Menichetti, E T\|Magnani, M
PMID:	17549067

119.
Journal:	Pharmacogenomics J. 2008 Aug;8(4):256-67.
Title:	The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer.
Author:	Capitain, O\|Boisdron-Celle, M\|Poirier, A-L\|Abadie-Lacourtoisie, S\|Morel, A\|Gamelin, E
PMID:	17700593

120.
Journal:	Br J Nutr. 2008 Feb;99(2):379-89. Epub 2007 Dec 6.
Title:	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.
Author:	Sharp, Linda\|Little, Julian\|Brockton, Nigel T\|Cotton, Seonaidh C\|Masson, Lindsey F\|Haites, Neva E\|Cassidy, Jim
PMID:	18053312

121.
Journal:	Pharmacogenet Genomics. 2008 Feb;18(2):161-8.
Title:	Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer.
Author:	Lurje, Georg\|Zhang, Wu\|Yang, Dongyun\|Groshen, Susan\|Hendifar, Andrew E\|Husain, Hatim\|Nagashima, Fumio\|Chang, Heung M\|Fazzone, William\|Ladner, Robert D\|Pohl, Alexandra\|Ning, Yan\|Iqbal, Syma\|El-Khoueiry, Anthony\|Lenz, Heinz-Josef
PMID:	18192902

122.
Journal:	Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):171-82.
Title:	Dietary vitamin B6 intake and the risk of colorectal cancer.
Author:	Theodoratou, Evropi\|Farrington, Susan M\|Tenesa, Albert\|McNeill, Geraldine\|Cetnarskyj, Roseanne\|Barnetson, Rebecca A\|Porteous, Mary E\|Dunlop, Malcolm G\|Campbell, Harry
PMID:	18199722

123.
Journal:	J Gastroenterol Hepatol. 2008 Jun;23(6):948-53.
Title:	Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer.
Author:	Yoshiya, Gen\|Takahata, Takenori\|Hanada, Naoyuki\|Suzuki, Kazuhiro\|Ishiguro, Atsushi\|Saito, Masato\|Sasaki, Mutsuo\|Fukuda, Shinsaku
PMID:	18205772

124.
Journal:	Clin Cancer Res. 2008 Feb 1;14(3):817-25.
Title:	Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.
Author:	Sharma, Rohini\|Hoskins, Janelle M\|Rivory, Laurent P\|Zucknick, Manuela\|London, Rosyln\|Liddle, Christopher\|Clarke, Stephen J
PMID:	18245544

125.
Journal:	BMC Cancer. 2008 Feb 12;8:50.
Title:	ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study.
Author:	Huang, Ming-Yii\|Fang, Wei-Yu\|Lee, Su-Chen\|Cheng, Tian-Lu\|Wang, Jaw-Yuan\|Lin, Shiu-Ru
PMID:	18267032

126.
Journal:	Cancer Causes Control. 2008 Sep;19(7):751-8.
Title:	Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial.
Author:	Murphy, Gwen\|Sansbury, Leah B\|Cross, Amanda J\|Stolzenberg-Solomon, Rachael\|Laiyemo, Adeyinka\|Albert, Paul S\|Wang, Zhuoqiao\|Schatzkin, Arthur\|Lehman, Teresa\|Kalidindi, Aravind\|Modali, Rama\|Lanza, Elaine
PMID:	18322814

127.
Journal:	J Hum Genet. 2008;53(4):340-8.
Title:	Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Author:	Mao, Renfang\|Fan, Yihui\|Jin, Yan\|Bai, Jing\|Fu, Songbin
PMID:	18340404

128.
Journal:	World J Gastroenterol. 2008 Jun 21;14(23):3662-71.
Title:	Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status.
Author:	Mokarram, Pooneh\|Naghibalhossaini, Fakhraddin\|Saberi Firoozi, Mehdi\|Hosseini, Seyed Vahid\|Izadpanah, Ahmad\|Salahi, Heshmetalah\|Malek-Hosseini, Seyed Ali\|Talei, Abdoulrasool\|Mojallal, Mehra
PMID:	18595133

129.
Journal:	Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2421-30.
Title:	Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.
Author:	Lightfoot, Tracy J\|Barrett, Jennifer H\|Bishop, Timothy\|Northwood, Emma L\|Smith, Gillian\|Wilkie, Murray J V\|Steele, Robert J C\|Carey, Francis A\|Key, Tim J\|Wolf, Roland\|Forman, David
PMID:	18703816

130.
Journal:	Asian Pac J Cancer Prev. 2008 Apr-Jun;9(2):203-8.
Title:	Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer.
Author:	Cao, Hai-Xia\|Gao, Chang-Ming\|Takezaki, Toshiro\|Wu, Jian-Zhong\|Ding, Jian-Hua\|Liu, Yan-Ting\|Li, Su-Ping\|Su, Ping\|Cao, Jia\|Hamajima, Nobuyuki\|Tajima, Kazuo
PMID:	18712959

131.
Journal:	Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2409-15.
Title:	MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial.
Author:	Levine, A Joan\|Wallace, Kristin\|Tsang, Shirley\|Haile, Robert W\|Saibil, Fred\|Ahnen, Dennis\|Cole, Bernard F\|Barry, Elizabeth L\|Munroe, David J\|Ali, Iqbal U\|Ueland, Per\|Baron, John A
PMID:	18768511

132.
Journal:	Vitam Horm. 2008;79:375-92.
Title:	Methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease.
Author:	Thomas, Philip\|Fenech, Michael
PMID:	18804702

133.
Journal:	Am J Clin Nutr. 2008 Oct;88(4):1149-58.
Title:	Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Author:	DeVos, Lauren\|Chanson, Aurelie\|Liu, Zhenhua\|Ciappio, Eric D\|Parnell, Laurence D\|Mason, Joel B\|Tucker, Katherine L\|Crott, Jimmy W
PMID:	18842806

134.
Journal:	BMC Cancer. 2008 Nov 7;8:326.
Title:	Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
Author:	Kury, Sebastien\|Buecher, Bruno\|Robiou-du-Pont, Sebastien\|Scoul, Catherine\|Colman, Helene\|Le Neel, Tanguy\|Le Houerou, Claire\|Faroux, Roger\|Ollivry, Jean\|Lafraise, Bernard\|Chupin, Louis-Dominique\|Sebille, Veronique\|Bezieau, Stephane
PMID:	18992148

135.
Journal:	Am J Clin Nutr. 2008 Nov;88(5):1413-8.
Title:	Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients.
Author:	Guerreiro, Catarina Sousa\|Carmona, Bruno\|Goncalves, Susana\|Carolino, Elisabete\|Fidalgo, Paulo\|Brito, Miguel\|Leitao, Carlos Nobre\|Cravo, Marilia
PMID:	18996879

136.
Journal:	Scand J Clin Lab Invest. 2008;68(5):393-401.
Title:	The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study.
Author:	Eklof, V\|Van Guelpen, B\|Hultdin, J\|Johansson, I\|Hallmans, G\|Palmqvist, R
PMID:	19172696

137.
Journal:	Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):659-62.
Title:	Association between the 1793G> A MTHFR polymorphism and sporadic colorectal cancer in Iran.
Author:	Haghighi, Mahdi Montazer\|Mohebbi, Seyed Reza\|Najjar Sadeghi, Rouhallah\|Vahedi, Mohsen\|Ghiasi, Somayeh\|Zali, Mohammad Reza
PMID:	19256756

138.
Journal:	J Nutrigenet Nutrigenomics. 2008;1(4):196-204.
Title:	Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.
Author:	Steck, Susan E\|Keku, Temitope\|Butler, Lesley M\|Galanko, Joseph\|Massa, Beri\|Millikan, Robert C\|Sandler, Robert S
PMID:	19776626

139.
Journal:	Int J Health Sci (Qassim). 2008 Jan;2(1):3-14.
Title:	Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women.
Author:	Mir, M Muzaffar\|Dar, Javid A\|Dar, Nazir A\|Dar, M Shafi\|Salam, Irfana\|Lone, M Maqbool\|Chowdary, Nissar A
PMID:	21475466

140.
Journal:	Pathol Oncol Res. 2009 Sep;15(3):335-44.
Title:	Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
Author:	Reti, Andrea\|Barna, Gabor\|Pap, Eva\|Adleff, Vilmos\|L Komlosi, Viktor\|Jeney, Andras\|Kralovanszky, Judit\|Budai, Barna
PMID:	19048402

141.
Journal:	Int J Cancer. 2009 May 1;124(9):1999-2005.
Title:	The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
Author:	Sohn, Kyoung-Jin\|Jang, Hyeran\|Campan, Mihaela\|Weisenberger, Daniel J\|Dickhout, Jeffrey\|Wang, Yi-Cheng\|Cho, Robert C\|Yates, Zoe\|Lucock, Mark\|Chiang, En-Pei\|Austin, Richard C\|Choi, Sang-Woon\|Laird, Peter W\|Kim, Young-In
PMID:	19123462

142.
Journal:	Eur J Hum Genet. 2009 May;17(5):629-35.
Title:	MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.
Author:	Reeves, Stuart G\|Meldrum, Cliff\|Groombridge, Claire\|Spigelman, Allan D\|Suchy, Janina\|Kurzawski, Grzegorz\|Lubinski, Jan\|McElduff, Patrick\|Scott, Rodney J
PMID:	19156174

143.
Journal:	Gut. 2009 Jun;58(6):805-11.
Title:	Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
Author:	Lawrance, A K\|Deng, L\|Rozen, R
PMID:	19174418

144.
Journal:	Clin Colorectal Cancer. 2009 Jan;8(1):43-8.
Title:	A study of the MTHFR gene polymorphism C677T in colorectal cancer.
Author:	Derwinger, Kristoffer\|Wettergren, Yvonne\|Odin, Elisabeth\|Carlsson, Goran\|Gustavsson, Bengt
PMID:	19203896

145.
Journal:	Int J Cancer. 2009 Jul 1;125(1):84-90.
Title:	The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer.
Author:	Iacopetta, Barry\|Heyworth, Jane\|Girschik, Jennifer\|Grieu, Fabienne\|Clayforth, Cassandra\|Fritschi, Lin
PMID:	19326430

146.
Journal:	Br J Cancer. 2009 May 19;100(10):1549-57.
Title:	Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer.
Author:	Gusella, M\|Frigo, A C\|Bolzonella, C\|Marinelli, R\|Barile, C\|Bononi, A\|Crepaldi, G\|Menon, D\|Stievano, L\|Toso, S\|Pasini, F\|Ferrazzi, E\|Padrini, R
PMID:	19384296

147.
Journal:	Br J Nutr. 2009 May;101(9):1295-9.
Title:	Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake.
Author:	van Breda, Simone G J\|van Delft, Joost H M\|Engels, Leopold G J B\|Kleinjans, Jos C S\|Mathers, John C
PMID:	19434801

148.
Journal:	Ann Oncol. 2009 Oct;20(10):1660-6.
Title:	MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer.
Author:	Afzal, S\|Jensen, S A\|Vainer, B\|Vogel, U\|Matsen, J P\|Sorensen, J B\|Andersen, P K\|Poulsen, H E
PMID:	19465420

149.
Journal:	Cancer Genomics Proteomics. 2009 May-Jun;6(3):183-8.
Title:	Association of the 677C -->T polymorphism in the MTHFR gene with colorectal cancer in Mexican patients.
Author:	Gallegos-Arreola, M P\|Garcia-Ortiz, J E\|Figuera, L E\|Puebla-Perez, A M\|Morgan-Villela, G\|Zuniga-Gonzalez, G M
PMID:	19487547

150.
Journal:	Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2195-201.
Title:	Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study.
Author:	Le Marchand, Loic\|White, Kami K\|Nomura, Abraham M Y\|Wilkens, Lynne R\|Selhub, Jacob S\|Tiirikainen, Maarit\|Goodman, Marc T\|Murphy, Suzanne P\|Henderson, Brian E\|Kolonel, Laurence N
PMID:	19661077

151.
Journal:	Pharmacogenomics. 2009 Aug;10(8):1285-94.
Title:	MTHFR gene polymorphisms and response to chemotherapy in colorectal cancer: a meta-analysis.
Author:	Zintzaras, Elias\|Ziogas, Dimitrios C\|Kitsios, Georgios D\|Papathanasiou, Afroditi A\|Lau, Joseph\|Raman, Gowri
PMID:	19663673

152.
Journal:	Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3086-96.
Title:	Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.
Author:	de Vogel, Stefan\|Wouters, Kim A D\|Gottschalk, Ralph W H\|van Schooten, Frederik J\|de Goeij, Anton F P M\|de Bruine, Adriaan P\|Goldbohm, Royle A\|van den Brandt, Piet A\|Weijenberg, Matty P\|van Engeland, Manon
PMID:	19843671

153.
Journal:	Am J Epidemiol. 2009 Nov 15;170(10):1207-21.
Title:	Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review.
Author:	Taioli, E\|Garza, M A\|Ahn, Y O\|Bishop, D T\|Bost, J\|Budai, B\|Chen, K\|Gemignani, F\|Keku, T\|Lima, C S P\|Le Marchand, L\|Matsuo, K\|Moreno, V\|Plaschke, J\|Pufulete, M\|Thomas, S B\|Toffoli, G\|Wolf, C R\|Moore, C G\|Little, J
PMID:	19846566

154.
Journal:	J Clin Oncol. 2009 Nov 20;27(33):5519-28.
Title:	Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial.
Author:	Braun, Michael S\|Richman, Susan D\|Thompson, Lindsay\|Daly, Catherine L\|Meade, Angela M\|Adlard, Julian W\|Allan, James M\|Parmar, Mahesh K B\|Quirke, Philip\|Seymour, Matthew T
PMID:	19858398

155.
Journal:	Cancer Biomark. 2009;5(6):233-40.
Title:	Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals.
Author:	El Awady, Mostafa K\|Karim, Amr M\|Hanna, Laila S\|El Husseiny, Lamia A\|El Sahar, Medhat\|Menem, Hanan A Abdel\|Meguid, Nagwa A
PMID:	20037199

156.
Journal:	Oncol Res. 2009;18(2-3):57-63.
Title:	Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer.
Author:	Haghighi, Mahdi Montazer\|Radpour, Ramin\|Mahmoudi, Touraj\|Mohebbi, Seyed Reza\|Vahedi, Mohsen\|Zali, Mohammad Reza
PMID:	20066895

157.
Journal:	J Gastrointestin Liver Dis. 2009 Dec;18(4):455-60.
Title:	C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer.
Author:	Osian, Gelu\|Procopciuc, Lucia\|Vlad, Liviu\|Iancu, Cornel\|Mocan, Teodora\|Mocan, Lucian
PMID:	20076818

158.
Journal:	Int J Colorectal Dis. 2010 Feb;25(2):141-51.
Title:	Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy.
Author:	Fernandez-Peralta, Antonia M\|Daimiel, Lydia\|Nejda, Nargisse\|Iglesias, Daniel\|Medina Arana, Vicente\|Gonzalez-Aguilera, Juan J
PMID:	19669769

159.
Journal:	Cancer Causes Control. 2010 Mar;21(3):331-45.
Title:	Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Author:	Hazra, Aditi\|Fuchs, Charles S\|Kawasaki, Takako\|Kirkner, Gregory J\|Hunter, David J\|Ogino, Shuji
PMID:	19936946

160.
Journal:	Cancer Causes Control. 2010 Apr;21(4):557-66.
Title:	One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study.
Author:	Van Guelpen, Bethany\|Dahlin, Anna M\|Hultdin, Johan\|Eklof, Vincy\|Johansson, Ingegerd\|Henriksson, Maria L\|Cullman, Inger\|Hallmans, Goran\|Palmqvist, Richard
PMID:	20012180

161.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):89-100.
Title:	Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.
Author:	Levine, A Joan\|Figueiredo, Jane C\|Lee, Won\|Poynter, Jenny N\|Conti, David\|Duggan, David J\|Campbell, Peter T\|Newcomb, Polly\|Martinez, Maria Elena\|Hopper, John L\|Le Marchand, Loic\|Baron, John A\|Limburg, Paul J\|Ulrich, Cornelia M\|Haile, Robert W
PMID:	20056627

162.
Journal:	Br J Clin Pharmacol. 2010 Jan;69(1):58-66.
Title:	Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients.
Author:	Etienne-Grimaldi, Marie-Christine\|Milano, Gerard\|Maindrault-Goebel, Frederique\|Chibaudel, Benoist\|Formento, Jean-Louis\|Francoual, Mireille\|Lledo, Gerard\|Andre, Thierry\|Mabro, May\|Mineur, Laurent\|Flesch, Michel\|Carola, Elisabeth\|de Gramont, Aimery
PMID:	20078613

163.
Journal:	Cancer Genet Cytogenet. 2010 Mar;197(2):142-51.
Title:	MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients.
Author:	Naghibalhossaini, Fakhraddin\|Mokarram, Pooneh\|Khalili, Islam\|Vasei, Mohammad\|Hosseini, Seyed Vahid\|Ashktorab, Hassan\|Rasti, Mozhgan\|Abdollahi, Kourosh
PMID:	20193847

164.
Journal:	Cancer Epidemiol. 2010 Jun;34(3):338-44.
Title:	Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype.
Author:	Karpinski, Pawel\|Myszka, Aleksander\|Ramsey, David\|Misiak, Blazej\|Gil, Justyna\|Laczmanska, Izabela\|Grzebieniak, Zygmunt\|Sebzda, Tadeusz\|Smigiel, Robert\|Stembalska, Agnieszka\|Sasiadek, Maria M
PMID:	20381446

165.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1328-40.
Title:	Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.
Author:	Eussen, Simone J P M\|Vollset, Stein Emil\|Igland, Jannicke\|Meyer, Klaus\|Fredriksen, Ase\|Ueland, Per Magne\|Jenab, Mazda\|Slimani, Nadia\|Boffetta, Paolo\|Overvad, Kim\|Tjonneland, Anne\|Olsen, Anja\|Clavel-Chapelon, Francoise\|Boutron-Ruault, Marie-Christine\|Moroi
PMID:	20447924

166.
Journal:	Pharmacogenomics. 2010 Jun;11(6):747-61.
Title:	Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.
Author:	Balboa, Emilia\|Duran, Goretti\|Lamas, Maria Jesus\|Gomez-Caamano, Antonio\|Celeiro-Munoz, Catuxa\|Lopez, Rafael\|Carracedo, Angel\|Barros, Francisco
PMID:	20504250

167.
Journal:	BMC Cancer. 2010 May 26;10:236.
Title:	Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population.
Author:	Cui, Lian-Hua\|Shin, Min-Ho\|Kweon, Sun-Seog\|Kim, Hee Nam\|Song, Hye-Rim\|Piao, Jin-Mei\|Choi, Jin-Su\|Shim, Hyun Jeong\|Hwang, Jun Eul\|Kim, Hyeong-Rok\|Park, Young-Kyu\|Kim, Soo-Hyun
PMID:	20504332

168.
Journal:	Indian J Med Res. 2010 May;131:659-64.
Title:	Association of methylenetetrahydrofolate reductase gene polymorphisms & colorectal cancer in India.
Author:	Chandy, Sunil\|Sadananda Adiga, M N\|Ramachandra, N\|Krishnamoorthy, S\|Ramaswamy, Girija\|Savithri, H S\|Krishnamoorthy, Lakshmi
PMID:	20516537

169.
Journal:	Mol Med. 2010 Sep-Oct;16(9-10):425-32.
Title:	MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer.
Author:	Wettergren, Yvonne\|Odin, Elisabeth\|Carlsson, Goran\|Gustavsson, Bengt
PMID:	20549016

170.
Journal:	J Epidemiol. 2010;20(4):329-38. Epub 2010 Jun 12.
Title:	Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors.
Author:	Promthet, Supannee Sriamporn\|Pientong, Chamsai\|Ekalaksananan, Tipaya\|Wiangnon, Surapon\|Poomphakwaen, Kirati\|Songserm, Nopparat\|Chopjitt, Peechanika\|Moore, Malcolm A\|Tokudome, Shinkan
PMID:	20551579

171.
Journal:	Chirurgia (Bucur). 2010 May-Jun;105(3):373-8.
Title:	[Correlation between C677T and A1298C mutations of the MTHFR gene and therapeutic prognostic elements in colorectal cancer].
Author:	Osian, G\|Procopciuc, L\|Vlad, L\|Mocan, T\|Cristea, P G
PMID:	20726304

172.
Journal:	J Int Med Res. 2010 May-Jun;38(3):870-83.
Title:	Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
Author:	Kristensen, M H\|Pedersen, P L\|Melsen, G V\|Ellehauge, J\|Mejer, J
PMID:	20819423

173.
Journal:	BMC Cancer. 2010 Oct 4;10:525.
Title:	SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
Author:	Komlosi, Viktor\|Hitre, Erika\|Pap, Eva\|Adleff, Vilmos\|Reti, Andrea\|Szekely, Eva\|Biro, Anna\|Rudnai, Peter\|Schoket, Bernadette\|Muller, Judit\|Toth, Bela\|Otto, Szabolcs\|Kasler, Miklos\|Kralovanszky, Judit\|Budai, Barna
PMID:	20920350

174.
Journal:	J Diet Suppl. 2010 Dec;7(4):325-40.
Title:	Folate supplementation induces differential dose-dependent modulation of proliferative phenotypes among cancerous and noncancerous oral cell lines in vitro.
Author:	McCabe, Jonathan\|Chang, Sarah\|Hajibandeh, Jeffrey\|Tran, Michael D\|Meeder, Colby A\|Sharma, Kanika\|Nguyen, Dieu-Hoa\|Moody, Michael\|Keiserman, Mark A\|Bergman, Christine J\|Kingsley, Karl
PMID:	22432562

175.
Journal:	Pharmacogenomics J. 2011 Feb;11(1):61-71.
Title:	Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer.
Author:	Glimelius, B\|Garmo, H\|Berglund, A\|Fredriksson, L A\|Berglund, M\|Kohnke, H\|Bystrom, P\|Sorbye, H\|Wadelius, M
PMID:	20177420

176.
Journal:	Pharmacogenomics J. 2011 Jun;11(3):214-26.
Title:	Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy.
Author:	Cecchin, E\|Agostini, M\|Pucciarelli, S\|De Paoli, A\|Canzonieri, V\|Sigon, R\|De Mattia, E\|Friso, M L\|Biason, P\|Visentin, M\|Nitti, D\|Toffoli, G
PMID:	20368715

177.
Journal:	Int J Cancer. 2011 Feb 1;128(3):644-52.
Title:	Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls.
Author:	Zacho, Jeppe\|Yazdanyar, Shiva\|Bojesen, Stig E\|Tybjaerg-Hansen, Anne\|Nordestgaard, Borge G
PMID:	20473868

178.
Journal:	Cancer Causes Control. 2011 Jan;22(1):1-12.
Title:	Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
Author:	de Vogel, Stefan\|Wouters, Kim A D\|Gottschalk, Ralph W H\|van Schooten, Frederik J\|de Goeij, Anton F P M\|de Bruine, Adriaan P\|Goldbohm, R Alexandra\|van den Brandt, Piet A\|van Engeland, Manon\|Weijenberg, Matty P
PMID:	20960050

179.
Journal:	Oncol Rep. 2011 Jan;25(1):167-72.
Title:	Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients.
Author:	Kim, Jong Woo\|Park, Hye Mi\|Choi, Young-Kook\|Chong, So Young\|Oh, Doyeun\|Kim, Nam Keun
PMID:	21109973

180.
Journal:	Scand J Gastroenterol. 2011 Apr;46(4):436-45.
Title:	Impact of MTHFR gene C677T polymorphism on Bcl-2 gene methylation and protein expression in colorectal cancer.
Author:	Zhu, Qinghui\|Jin, Zhonggan\|Yuan, Ya\|Lu, Qing\|Ge, Danhong\|Zong, Ming
PMID:	21128871

181.
Journal:	Br J Clin Pharmacol. 2011 Jul;72(1):162-3.
Title:	5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes.
Author:	Pardini, Barbara\|Kumar, Rajiv\|Naccarati, Alessio\|Novotny, Jan\|Prasad, Rashmi B\|Forsti, Asta\|Hemminki, Kari\|Vodicka, Pavel\|Lorenzo Bermejo, Justo
PMID:	21204909

182.
Journal:	Mutat Res. 2011 Mar 18;721(1):74-80.
Title:	MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.
Author:	Pardini, Barbara\|Kumar, Rajiv\|Naccarati, Alessio\|Prasad, Rashmi B\|Forsti, Asta\|Polakova, Veronika\|Vodickova, Ludmila\|Novotny, Jan\|Hemminki, Kari\|Vodicka, Pavel
PMID:	21211571

183.
Journal:	J Clin Oncol. 2011 May 1;29(13):1722-7.
Title:	Clotting factor gene polymorphisms and colorectal cancer risk.
Author:	Vossen, Carla Y\|Hoffmeister, Michael\|Chang-Claude, Jenny C\|Rosendaal, Frits R\|Brenner, Hermann
PMID:	21422408

184.
Journal:	Cancer Causes Control. 2011 Jun;22(6):929-36.
Title:	Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case-control study.
Author:	Le Marchand, Loic\|Wang, Hansong\|Selhub, Jacob\|Vogt, Thomas M\|Yokochi, Lance\|Decker, Robert
PMID:	21437631

185.
Journal:	DNA Cell Biol. 2011 Oct;30(10):771-6.
Title:	Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer.
Author:	Jokic, Mladen\|Brcic-Kostic, Krunoslav\|Stefulj, Jasminka\|Catela Ivkovic, Tina\|Bozo, Loncar\|Gamulin, Marija\|Kapitanovic, Sanja
PMID:	21438757

186.
Journal:	Nutr Cancer. 2011;63(3):357-66.
Title:	Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women.
Author:	Curtin, Karen\|Samowitz, Wade S\|Ulrich, Cornelia M\|Wolff, Roger K\|Herrick, Jennifer S\|Caan, Bette J\|Slattery, Martha L
PMID:	21462086

187.
Journal:	Clin Cancer Res. 2011 Jun 1;17(11):3822-9.
Title:	Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients.
Author:	Afzal, Shoaib\|Gusella, Milena\|Vainer, Ben\|Vogel, Ulla B\|Andersen, Jon T\|Broedbaek, Kasper\|Petersen, Morten\|Jimenez-Solem, Espen\|Bertolaso, Laura\|Barile, Carmen\|Padrini, Roberto\|Pasini, Felice\|Jensen, Soren A\|Poulsen, Henrik E
PMID:	21471424

188.
Journal:	Int J Mol Epidemiol Genet. 2011 Jan 1;2(1):1-8. Epub 2010 Nov 5.
Title:	Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
Author:	Curtin, Karen\|Ulrich, Cornelia M\|Samowitz, Wade S\|Wolff, Roger K\|Duggan, David J\|Makar, Karen W\|Caan, Bette J\|Slattery, Martha L
PMID:	21537397

189.
Journal:	J Korean Soc Coloproctol. 2011 Apr;27(2):78-82.
Title:	Relationship between Metabolic Syndrome and MTHFR Polymorphism in Colorectal Cancer.
Author:	Kang, Bong Su\|Ahn, Dae Ho\|Kim, Nam Keun\|Kim, Jong Woo
PMID:	21602966

190.
Journal:	Tumour Biol. 2011 Oct;32(5):853-61.
Title:	Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Author:	Guimaraes, Jose Luiz Miranda\|Ayrizono, Maria de Lurdes\|Coy, Claudio Saddy Rodrigues\|Lima, Carmen Silvia Passos
PMID:	21603981

191.
Journal:	Genet Mol Res. 2011 Jun 21;10(2):1200-10.
Title:	Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population.
Author:	Sameer, A S\|Shah, Z A\|Nissar, S\|Mudassar, S\|Siddiqi, M A
PMID:	21732284

192.
Journal:	Curr Drug Metab. 2011 Dec;12(10):918-31.
Title:	Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients.
Author:	Gnoni, Antonio\|Russo, Antonio\|Silvestris, Nicola\|Maiello, Evaristo\|Vacca, Angelo\|Marech, Ilaria\|Numico, Gianmauro\|Paradiso, Angelo\|Lorusso, Vito\|Azzariti, Amalia
PMID:	21787270

193.
Journal:	BMC Cancer. 2011 Aug 5;11:339.
Title:	Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins.
Author:	Abuli, Anna\|Fernandez-Rozadilla, Ceres\|Alonso-Espinaco, Virginia\|Munoz, Jenifer\|Gonzalo, Victoria\|Bessa, Xavier\|Gonzalez, Dolors\|Clofent, Joan\|Cubiella, Joaquin\|Morillas, Juan D\|Rigau, Joaquim\|Latorre, Mercedes\|Fernandez-Banares, Fernando\|Pena, Elena\|Ries
PMID:	21819567

194.
Journal:	Onkologie. 2011;34(8-9):422-6.
Title:	Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers.
Author:	Prasad, Vidudala V T S\|Wilkhoo, Harpreet
PMID:	21934341

195.
Journal:	Br J Cancer. 2011 Nov 22;105(11):1654-62.
Title:	Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer.
Author:	Thomas, F\|Motsinger-Reif, A A\|Hoskins, J M\|Dvorak, A\|Roy, S\|Alyasiri, A\|Myerson, R J\|Fleshman, J W\|Tan, B R\|McLeod, H L
PMID:	22045187

196.
Journal:	Genet Mol Res. 2011 Dec 14;10(4):3738-46.
Title:	Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population.
Author:	Li, H\|Xu, W L\|Shen, H L\|Chen, Q Y\|Hui, L L\|Long, L L\|Zhu, X L
PMID:	22194208

197.
Journal:	Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):138-44.
Title:	X-ray cross-complementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients.
Author:	Lamas, Maria J\|Duran, Goretti\|Gomez, Antonio\|Balboa, Emilia\|Anido, Urbano\|Bernardez, Beatriz\|Rana-Diez, Pablo\|Lopez, Rafael\|Carracedo, Angel\|Barros, Francisco
PMID:	21167658

198.
Journal:	Am J Clin Nutr. 2012 Feb;95(2):405-12.
Title:	Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea.
Author:	Kim, Jeongseon\|Cho, Young Ae\|Kim, Dong-Hyun\|Lee, Bong-Hwa\|Hwang, Dae-Yong\|Jeong, Jinyoung\|Lee, Hun-Jae\|Matsuo, Keitaro\|Tajima, Kazuo\|Ahn, Yoon-Ok
PMID:	22218157

199.
Journal:	Int J Colorectal Dis. 2012 Oct;27(10):1387-8. Epub 2012 Feb 21.
Title:	Letter to the editor: a meta-analyses of association between polymorphism of MTHFR A1298C and colorectal cancer risk.
Author:	Ge, Hong\|Zheng, Xiaoli\|Zhao, Erjiang\|Sheng, Xuewen\|Lu, Su\|Cheng, Siguo\|Yu, Jinming
PMID:	22350268

200.
Journal:	Cancer Causes Control. 2012 Apr;23(4):537-45.
Title:	Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies.
Author:	Lee, Jung Eun\|Wei, Esther K\|Fuchs, Charles S\|Hunter, David J\|Lee, I-Min\|Selhub, Jacob\|Stampfer, Meir J\|Willett, Walter C\|Ma, Jing\|Giovannucci, Edward
PMID:	22367721

201.
Journal:	Pharmacogenet Genomics. 2012 Apr;22(4):290-304.
Title:	Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis.
Author:	Jennings, Barbara Anne\|Kwok, Chun Shing\|Willis, Gavin\|Matthews, Victoria\|Wawruch, Pawel\|Loke, Yoon Kong
PMID:	22388795

202.
Journal:	Colorectal Dis. 2012 Sep;14(9):e573-86.
Title:	A comparison of approaches for association studies of polymorphisms and colorectal cancer risk.
Author:	Ramsey, S D\|Holmes, R S\|McDermott, C L\|Blough, D K\|Petrin, K L\|Poole, E M\|Ulrich, C M
PMID:	22390411

203.
Journal:	Br J Clin Pharmacol. 2012 May;73(5):776-85.
Title:	Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5-fluorouracil-based therapy together with cetuximab-irinotecan.
Author:	Etienne-Grimaldi, Marie-Christine\|Bennouna, Jaafar\|Formento, Jean-Louis\|Douillard, Jean-Yves\|Francoual, Mireille\|Hennebelle, Isabelle\|Chatelut, Etienne\|Francois, Eric\|Faroux, Roger\|El Hannani, Chaza\|Jacob, Jacques-Henri\|Milano, Gerard
PMID:	22486600

204.
Journal:	Int J Clin Exp Med. 2012;5(2):186-94. Epub 2012 Apr 6.
Title:	ERCC1 C118T associates with response to FOLFOX4 chemotherapy in colorectal cancer patients in Han Chinese.
Author:	Chai, Haina\|Pan, Jie\|Zhang, Xuelin\|Zhang, Xiaoyan\|Shen, Xiaoying\|Li, Hang\|Zhang, Kehao\|Yang, Changqing\|Sheng, Haihui\|Gao, Hengjun
PMID:	22567180

205.
Journal:	Int J Biol Sci. 2012;8(6):819-30.
Title:	The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.
Author:	Zhou, Daijun\|Mei, Qiang\|Luo, Han\|Tang, Bo\|Yu, Peiwu
PMID:	22719222

206.
Journal:	Mol Biol Rep. 2012 Oct;39(10):9669-79.
Title:	MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.
Author:	Sheng, Xuewen\|Zhang, Yanxi\|Zhao, Erjiang\|Lu, Su\|Zheng, Xiaoli\|Ge, Hong\|Lu, Weiquan
PMID:	22729883

207.
Journal:	Asian Pac J Cancer Prev. 2012;13(4):1203-8.
Title:	MTHFR C677T polymorphism and colorectal cancer risk in Asians, a meta-analysis of 21 studies.
Author:	Yang, Zhen\|Zhang, Xie-Fu\|Liu, Hong-Xiang\|Hao, Yong-Shun\|Zhao, Chun-Lin
PMID:	22799306

208.
Journal:	Oncol Lett. 2012 Aug;4(2):365-369.
Title:	Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study.
Author:	Yin, Guancheng\|Ming, Hanxin\|Zheng, Xiao\|Xuan, Yi\|Liang, Jianwei\|Jin, Xing
PMID:	22844384

209.
Journal:	Tumour Biol. 2012 Dec;33(6):2041-51.
Title:	Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians.
Author:	Zhong, Shan\|Yang, Jia-He\|Liu, Kai\|Jiao, B H\|Chang, Zhi-Jie
PMID:	22890827

210.
Journal:	Clin Res Hepatol Gastroenterol. 2012 Aug;36(4):345-51.
Title:	Insulin-like growth factor 2 gene methylation in peripheral blood mononuclear cells of patients with hepatitis C related cirrhosis or hepatocellular carcinoma.
Author:	Couvert, Philippe\|Carrie, Alain\|Tezenas du Montcel, Sophie\|Vaysse, Jenny\|Sutton, Angela\|Barget, Nathalie\|Trinchet, Jean-Claude\|Beaugrand, Michel\|Ganne, Nathalie\|Giral, Philippe\|Chelly, Jamel
PMID:	22902352

211.
Journal:	Pharmacogenomics. 2012 Jul;13(10):1173-91.
Title:	Pharmacogenetic markers of toxicity for chemotherapy in colorectal cancer patients.
Author:	Cortejoso, Lucia\|Lopez-Fernandez, Luis A
PMID:	22909207

212.
Journal:	J Natl Cancer Inst. 2012 Oct 3;104(19):1433-57.
Title:	Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancer.
Author:	Theodoratou, Evropi\|Montazeri, Zahra\|Hawken, Steven\|Allum, Genevieve CdL\|Gong, Jacintha\|Tait, Valerie\|Kirac, Iva\|Tazari, Mahmood\|Farrington, Susan M\|Demarsh, Alex\|Zgaga, Lina\|Landry, Denise\|Benson, Helen E\|Read, Stephanie H\|Rudan, Igor\|Tenesa, Albert\|Dunl
PMID:	23019048

213.
Journal:	Asian Pac J Cancer Prev. 2012;13(8):4017-23.
Title:	Risk factors for rectal cancer and methylenetetrahydrofolate reductase polymorphisms in a population in Northeast Thailand.
Author:	Promthet, Supannee\|Pientong, Chamsai\|Ekalaksananan, Tipaya\|Songserm, Nopparat\|Poomphakwaen, Kirati\|Chopjitt, Peechanika\|Wiangnon, Surapon\|Tokudome, Shinkan
PMID:	23098510

214.
Journal:	J Cancer Epidemiol. 2012;2012:952508.
Title:	Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis.
Author:	Kennedy, Deborah A\|Stern, Seth J\|Matok, Ilan\|Moretti, Myla E\|Sarkar, Moumita\|Adams-Webber, Thomasin\|Koren, Gideon
PMID:	23125859

215.
Journal:	Genome Med. 2012 Nov 29;4(11):92.
Title:	Predictors of patient uptake of colorectal cancer gene environment risk assessment.
Author:	Hall, Michael J\|Manne, Sharon L\|Myers, Ronald E\|Keenan, Eileen M\|Balshem, Andrew M\|Weinberg, David S
PMID:	23194586

216.
Journal:	J Nutrigenet Nutrigenomics. 2012;5(6):327-38.
Title:	Short-term folate supplementation in physiological doses has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma.
Author:	Al-Ghnaniem Abbadi, Reyad\|Emery, Peter\|Pufulete, Maria
PMID:	23328702

217.
Journal:	Int J Colorectal Dis. 2013 Mar;28(3):429-30.
Title:	Letter to the editor: a meta-analysis of MTHFR C677T polymorphism and colorectal cancer risk in East Asians.
Author:	Jia, Yunhe\|Li, Mingqi\|Xue, Weinan\|Cui, Binbin
PMID:	22576904

218.
Journal:	Mol Nutr Food Res. 2013 Apr;57(4):721-34.
Title:	Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.
Author:	Liu, Amy Y\|Scherer, Dominique\|Poole, Elizabeth\|Potter, John D\|Curtin, Karen\|Makar, Karen\|Slattery, Martha L\|Caan, Bette J\|Ulrich, Cornelia M
PMID:	22961839

219.
Journal:	Mol Nutr Food Res. 2013 Apr;57(4):686-97.
Title:	Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.
Author:	Leclerc, Daniel\|Cao, Yuanhang\|Deng, Liyuan\|Mikael, Leonie G\|Wu, Qing\|Rozen, Rima
PMID:	23001810

220.
Journal:	Cancer Chemother Pharmacol. 2013 Apr;71(4):843-51.
Title:	Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer.
Author:	Lee, Kyung-Hun\|Chang, Hye Jung\|Han, Sae-Won\|Oh, Do-Youn\|Im, Seock-Ah\|Bang, Yung-Jue\|Kim, Sun Young\|Lee, Keun-Wook\|Kim, Jee Hyun\|Hong, Yong Sang\|Kim, Tae Won\|Park, Young Suk\|Kang, Won Ki\|Shin, Sang Joon\|Ahn, Joong Bae\|Kang, Gyeong Hoon\|Jeong, Seung-Yong\|Pa
PMID:	23314736

221.
Journal:	Med Oncol. 2013 Mar;30(1):467.
Title:	Association between MTHFR polymorphisms and overall survival of colorectal cancer patients in Northeast China.
Author:	Zhu, Lin\|Wang, Fan\|Hu, FuLan\|Wang, YiBaina\|Li, DanDan\|Dong, XinShu\|Cui, BinBin\|Zhao, YaShuang
PMID:	23392576

222.
Journal:	Mol Nutr Food Res. 2013 Apr;57(4):607-27.
Title:	Folate-genetics and colorectal neoplasia: what we know and need to know next.
Author:	Figueiredo, Jane C\|Levine, A Joan\|Crott, Jimmy W\|Baurley, James\|Haile, Robert W
PMID:	23401104

223.
Journal:	Int J Colorectal Dis. 2013 Sep;28(9):1187-93.
Title:	Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability.
Author:	Delgado-Plasencia, Luciano\|Medina-Arana, Vicente\|Bravo-Gutierrez, Alberto\|Perez-Palma, Julian\|Alvarez-Arguelles, Hugo\|Salido-Ruiz, Eduardo\|Fernandez-Peralta, Antonia M\|Gonzalez-Aguilera, Juan J
PMID:	23422951

224.
Journal:	PLoS One. 2013;8(2):e55332.
Title:	The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies.
Author:	Teng, Zan\|Wang, Lei\|Cai, Shuang\|Yu, Ping\|Wang, Jin\|Gong, Jing\|Liu, Yunpeng
PMID:	23437053

225.
Journal:	PLoS One. 2013 Apr 23;8(4):e61469.
Title:	MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland.
Author:	Negandhi, Amit A\|Hyde, Angela\|Dicks, Elizabeth\|Pollett, William\|Younghusband, Banfield H\|Parfrey, Patrick\|Green, Roger C\|Savas, Sevtap
PMID:	23626689

226.
Journal:	Genes Chromosomes Cancer. 2013 Oct;52(10):945-53.
Title:	Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study.
Author:	Ashmore, Joseph H\|Lesko, Samuel M\|Muscat, Joshua E\|Gallagher, Carla J\|Berg, Arthur S\|Miller, Paige E\|Hartman, Terryl J\|Lazarus, Philip
PMID:	23893618

227.
Journal:	Asian Pac J Cancer Prev. 2013;14(8):4559-65.
Title:	Allele and genotype frequencies of the polymorphic methylenetetrahydrofolate reductase and colorectal cancer among Jordanian population.
Author:	Yousef, Al-Motassem\|Shomaf, Maha\|Berger, Sondra\|Ababneh, Nidaa\|Bobali, Yahya\|Ali, Dema\|Al-Hasan, Sara\|Diab, Ola\|Ismail, Said
PMID:	24083702

228.
Journal:	Am J Clin Nutr. 2013 Dec;98(6):1564-74.
Title:	The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia.
Author:	Hanks, Joanna\|Ayed, Iyeman\|Kukreja, Neil\|Rogers, Chris\|Harris, Jessica\|Gheorghiu, Alina\|Liu, Chee Ling\|Emery, Peter\|Pufulete, Maria
PMID:	24108782

229.
Journal:	Oncol Lett. 2013 Sep;6(3):648-654.
Title:	Polymorphisms of GSTP1, ERCC2 and TS-3'UTR are associated with the clinical outcome of mFOLFOX6 in colorectal cancer patients.
Author:	Kumamoto, Kensuke\|Ishibashi, Keiichiro\|Okada, Norimichi\|Tajima, Yusuke\|Kuwabara, Kouki\|Kumagai, Yoichi\|Baba, Hiroyuki\|Haga, Norihiro\|Ishida, Hideyuki
PMID:	24137384

230.
Journal:	Cancer Prev Res (Phila). 2013 Nov;6(11):1171-81.
Title:	Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients.
Author:	Leclerc, Daniel\|Levesque, Nancy\|Cao, Yuanhang\|Deng, Liyuan\|Wu, Qing\|Powell, Jasmine\|Sapienza, Carmen\|Rozen, Rima
PMID:	24169962

231.
Journal:	Asian Pac J Cancer Prev. 2013;14(10):5609-14.
Title:	Genes and SNPs associated with non-hereditary and hereditary colorectal cancer.
Author:	Nassiri, Mohammadreza\|Kooshyar, Mohammad Mahdi\|Roudbar, Zahra\|Mahdavi, Morteza\|Doosti, Mohammad
PMID:	24289550

232.
Journal:	Biomed Rep. 2013 Sep;1(5):781-791.
Title:	Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta-analysis.
Author:	Zhao, Mengmeng\|Li, Xuelian\|Xing, Chengzhong\|Zhou, Baosen
PMID:	24649029

233.
Journal:	Pituitary. 2014 Jun;17(3):257-66.
Title:	MTHFR C677T polymorphism, folate status and colon cancer risk in acromegalic patients.
Author:	Torre, Maria Luisa\|Russo, Giuseppina T\|Ragonese, Marta\|Giandalia, Annalisa\|De Menis, Ernesto\|Arnaldi, Giorgio\|Alibrandi, Angela\|Buda, Carmelo\|Romanello, Giovanni\|Romeo, Elisabetta L\|Cucinotta, Domenico\|Trimarchi, Francesco\|Cannavo, Salvatore
PMID:	23807201

234.
Journal:	Gene. 2014 Jan 10;533(2):558-64.
Title:	Polymorphisms of folate metabolism-related genes and survival of patients with colorectal cancer in the Korean population.
Author:	Jang, Moon Ju\|Kim, Jong Woo\|Jeon, Young Joo\|Chong, So Young\|Hong, Sung Pyo\|Hwang, Seong Gyu\|Oh, Doyeun\|Cho, Yun Kyung\|Ji, Young Geon\|Kim, Nam Keun
PMID:	24100087

235.
Journal:	Clin Transl Oncol. 2014 Jul;16(7):623-9.
Title:	Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects.
Author:	Guo, X-P\|Wang, Y\|Zhao, H\|Song, S-D\|Zhou, J\|Han, Y
PMID:	24193867

236.
Journal:	Oncol Rep. 2014 Jan;31(1):19-26.
Title:	Demethylation effect of the antineoplaston AS2-1 on genes in colon cancer cells.
Author:	Ushijima, Masataka\|Ogata, Yutaka\|Tsuda, Hideaki\|Akagi, Yoshito\|Matono, Keiko\|Shirouzu, Kazuo
PMID:	24213840

237.
Journal:	Epigenetics. 2014 Apr;9(4):621-33.
Title:	Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism.
Author:	Coppede, Fabio\|Migheli, Francesca\|Lopomo, Angela\|Failli, Alessandra\|Legitimo, Annalisa\|Consolini, Rita\|Fontanini, Gabriella\|Sensi, Elisa\|Servadio, Adele\|Seccia, Massimo\|Zocco, Giuseppe\|Chiarugi, Massimo\|Spisni, Roberto\|Migliore, Lucia
PMID:	24500500

238.
Journal:	Pharmacogenomics. 2014 Feb;15(3):349-59.
Title:	Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer.
Author:	Rai, Padmalatha S\|Pai, Ganesh C\|Alvares, Jose F\|Bellampalli, Ravishankara\|Gopinath, Puthiya M\|Satyamoorthy, Kapaettu
PMID:	24533714

239.
Journal:	Clin Med Insights Oncol. 2014 Feb 17;8:15-20.
Title:	Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer.
Author:	Taflin, Helena\|Wettergren, Yvonne\|Odin, Elisabeth\|Carlsson, Goran\|Derwinger, Kristoffer
PMID:	24596472

240.
Journal:	Genet Test Mol Biomarkers. 2014 May;18(5):313-22.
Title:	Effects of MTHFR genetic polymorphisms on toxicity and clinical response of irinotecan-based chemotherapy in patients with colorectal cancer.
Author:	Li, Ping\|Chen, Quan\|Wang, Ya-Di\|Ha, Min-Wen
PMID:	24611457

241.
Journal:	Ann Coloproctol. 2014 Feb;30(1):18-22.
Title:	Clinical characteristics of colorectal cancer patients with a second primary cancer.
Author:	Lee, Jin Woo\|Kim, Jong Woo\|Kim, Nam Keun
PMID:	24639966

242.
Journal:	Cancer Causes Control. 2014 Sep;25(9):1119-29.
Title:	Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study.
Author:	Jung, Audrey Y\|van Duijnhoven, Franzel J B\|Nagengast, Fokko M\|Botma, Akke\|Heine-Broring, Renate C\|Kleibeuker, Jan H\|Vasen, Hans F A\|Harryvan, Jan L\|Winkels, Renate M\|Kampman, Ellen
PMID:	24916333

243.
Journal:	Mol Cancer Ther. 2014 Sep;13(9):2226-37.
Title:	Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy.
Author:	Custodio, Ana\|Moreno-Rubio, Juan\|Aparicio, Jorge\|Gallego-Plazas, Javier\|Yaya, Ricardo\|Maurel, Joan\|Rodriguez-Salas, Nuria\|Burgos, Emilio\|Ramos, David\|Calatrava, Ana\|Andrada, Encarna\|Diaz-Lopez, Esther\|Sanchez, Antonio\|Madero, Rosario\|Cejas, Paloma\|Feliu,
PMID:	24980946

244.
Journal:	Cancer. 2014 Nov 1;120(21):3329-3337.
Title:	Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304).
Author:	Ulrich, Cornelia M\|Rankin, Cathryn\|Toriola, Adetunji T\|Makar, Karen W\|Altug-Teber, Ozge\|Benedetti, Jacqueline K\|Holmes, Rebecca S\|Smalley, Stephen R\|Blanke, Charles D\|Lenz, Heinz-Josef
PMID:	25041994

245.
Journal:	Proteomics. 2014 Nov;14(21-22):2558-65.
Title:	Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.
Author:	Leclerc, Daniel\|Dejgaard, Kurt\|Mazur, Alexander\|Deng, Liyuan\|Wu, Qing\|Nilsson, Tommy\|Rozen, Rima
PMID:	25081070

246.
Journal:	Asian Pac J Cancer Prev. 2014;15(18):7731-5.
Title:	Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are associated with colorectal cancer risk in the Turkish population.
Author:	Ozen, Filiz\|Sen, Metin\|Ozdemir, Ozturk
PMID:	25292054

247.
Journal:	Ann Intern Med. 2014 Oct 21;161(8):537-45.
Title:	Genetic and environmental risk assessment and colorectal cancer screening in an average-risk population: a randomized trial.
Author:	Weinberg, David S\|Myers, Ronald E\|Keenan, Eileen\|Ruth, Karen\|Sifri, Randa\|Ziring, Barry\|Ross, Eric\|Manne, Sharon L
PMID:	25329201

248.
Journal:	Asian Pac J Cancer Prev. 2014;15(19):8245-50.
Title:	5,10-Methylenetetrahydrofolate reductase polymorphisms and colon cancer risk: a meta-analysis.
Author:	Fang, Xin-Yu\|Xu, Wang-Dong\|Huang, Qian\|Yang, Xiao-Ke\|Liu, Yan-Yan\|Leng, Rui-Xue\|Pan, Hai-Feng\|Ye, Dong-Qing
PMID:	25339013

249.
Journal:	Sci Rep. 2014 Nov 5;4:6828.
Title:	Genetic markers for toxicity of adjuvant oxaliplatin and fluoropyrimidines in the phase III TOSCA trial in high-risk colon cancer patients.
Author:	Ruzzo, Annamaria\|Graziano, Francesco\|Galli, Fabio\|Giacomini, Elisa\|Floriani, Irene\|Galli, Francesca\|Rulli, Eliana\|Lonardi, Sara\|Ronzoni, Monica\|Massidda, Bruno\|Zagonel, Vittorina\|Pella, Nicoletta\|Mucciarini, Claudia\|Labianca, Roberto\|Ionta, Maria Teresa\|V
PMID:	25370899

250.
Journal:	Am J Ther. 2015 Mar-Apr;22(2):e36-9.
Title:	Dihydropyrimidine dehydrogenase 85T>C mutation is associated with ocular toxicity of 5-fluorouracil: a case report.
Author:	Baskin, Yasemin\|Amirfallah, Arsalan\|Unal, Olcun Umit\|Calibasi, Gizem\|Oztop, Ilhan
PMID:	24434920

251.
Journal:	Cancer Lett. 2015 Jan 28;356(2 Pt A):224-30.
Title:	How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.
Author:	Jennings, Barbara Anne\|Willis, Gavin
PMID:	24614284

252.
Journal:	Pharmacogenomics J. 2015 Jun;15(3):219-25.
Title:	MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin.
Author:	Cecchin, E\|Perrone, G\|Nobili, S\|Polesel, J\|De Mattia, E\|Zanusso, C\|Petreni, P\|Lonardi, S\|Pella, N\|D'Andrea, M\|Errante, D\|Rizzolio, F\|Mazzei, T\|Landini, I\|Mini, E\|Toffoli, G
PMID:	25331073

253.
Journal:	Cancer Chemother Pharmacol. 2015 Apr;75(4):763-72.
Title:	Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy.
Author:	Joerger, M\|Huitema, A D R\|Boot, H\|Cats, A\|Doodeman, V D\|Smits, P H M\|Vainchtein, L\|Rosing, H\|Meijerman, I\|Zueger, M\|Meulendijks, D\|Cerny, T D\|Beijnen, J H\|Schellens, J H M
PMID:	25677447

254.
Journal:	Oncotarget. 2015 Mar 20;6(8):6422-30.
Title:	Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer.
Author:	Garcia-Gonzalez, Xandra\|Cortejoso, Lucia\|Garcia, Maria I\|Garcia-Alfonso, Pilar\|Robles, Luis\|Gravalos, Cristina\|Gonzalez-Haba, Eva\|Marta, Pellicer\|Sanjurjo, Maria\|Lopez-Fernandez, Luis A
PMID:	25691056

255.
Journal:	Eur J Clin Pharmacol. 2015 May;71(5):529-39.
Title:	Germ line polymorphisms as predictive markers for pre-surgical radiochemotherapy in locally advanced rectal cancer: a 5-year literature update and critical review.
Author:	Pezzolo, Elisa\|Modena, Yasmina\|Corso, Barbara\|Giusti, Pietro\|Gusella, Milena
PMID:	25740678

256.
Journal:	Pharmacogenomics. 2015;16(4):413-25.
Title:	Evaluation of association studies and meta-analyses of MTHFR gene polymorphisms in colorectal cancer.
Author:	Haerian, Batoul Sadat\|Haerian, Monir Sadat
PMID:	25823789

257.
Journal:	Am J Clin Nutr. 2015 Jun;101(6):1295-304.
Title:	Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Author:	Zinck, John Wr\|de Groh, Margaret\|MacFarlane, Amanda J
PMID:	25948668

258.
Journal:	Sci Rep. 2015 Jun 5;5:11006.
Title:	Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans.
Author:	Jeon, Young Joo\|Kim, Jong Woo\|Park, Hye Mi\|Kim, Jung O\|Jang, Hyo Geun\|Oh, Jisu\|Hwang, Seong Gyu\|Kwon, Sung Won\|Oh, Doyeun\|Kim, Nam Keun
PMID:	26046315

259.
Journal:	Tumour Biol. 2015 Nov;36(11):8953-72.
Title:	Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Author:	Xie, Shu-Zhe\|Liu, Zhi-Zhong\|Yu, Jun-hua\|Liu, Li\|Wang, Wei\|Xie, Dao-Lin\|Qin, Jiang-Bo
PMID:	26081619

260.
Journal:	Cancer. 2015 Oct 15;121(20):3684-91.
Title:	Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.
Author:	Cheng, Ting-Yuan David\|Makar, Karen W\|Neuhouser, Marian L\|Miller, Joshua W\|Song, Xiaoling\|Brown, Elissa C\|Beresford, Shirley A A\|Zheng, Yingye\|Poole, Elizabeth M\|Galbraith, Rachel L\|Duggan, David J\|Habermann, Nina\|Bailey, Lynn B\|Maneval, David R\|Caudill,
PMID:	26108676

261.
Journal:	Anticancer Drugs. 2015 Sep;26(8):888-93.
Title:	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment in Taiwan colorectal cancer.
Author:	Wu, Nai-Chun\|Su, Shih-Ming\|Lin, Tai-Jung\|Chin, Jen\|Hou, Chun-Fang\|Yang, Jhong-Ying\|Liu, Wen-Sheng\|Chang, Li-Ching
PMID:	26111049

262.
Journal:	Mol Clin Oncol. 2015 May;3(3):639-648.
Title:	Association between folate metabolism-related polymorphisms and colorectal cancer risk.
Author:	Kim, Jong Woo\|Jeon, Young Joo\|Jang, Moon Ju\|Kim, Jung O\|Chong, So Young\|Ko, Kwang Hyun\|Hwang, Seong Gyu\|Oh, Doyeun\|Oh, Jisu\|Kim, Nam Keun
PMID:	26137281

263.
Journal:	Cancer. 2015 Nov 1;121(21):3862-8.
Title:	A phase 1 clinical trial of sequential pralatrexate followed by a 48-hour infusion of 5-fluorouracil given every other week in adult patients with solid tumors.
Author:	Grem, Jean L\|Kos, Mary E\|Evande, Ruby E\|Meza, Jane L\|Schwarz, James K
PMID:	26242208

264.
Journal:	J Med Case Rep. 2015 Aug 20;9:175.
Title:	Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature.
Author:	Cascella, Marco\|Arcamone, Manuela\|Morelli, Emanuela\|Viscardi, Daniela\|Russo, Viera\|De Franciscis, Silvia\|Belli, Andrea\|Accardo, Rosanna\|Caliendo, Domenico\|De Luca, Elena\|Di Caprio, Barbara\|Di Sauro, Francesco\|Giannoni, Giovanni\|Iermano, Carmine\|Maciariell
PMID:	26289647

265.
Journal:	J Natl Cancer Inst. 2015 Sep 15;107(12):djv260.
Title:	Unmetabolized Folic Acid in Prediagnostic Plasma and the Risk of Colorectal Cancer.
Author:	Cho, Eunyoung\|Zhang, Xuehong\|Townsend, Mary K\|Selhub, Jacob\|Paul, Ligi\|Rosner, Bernard\|Fuchs, Charles S\|Willett, Walter C\|Giovannucci, Edward L
PMID:	26376686

266.
Journal:	Med Sci Monit. 2015 Oct 12;21:3068-76.
Title:	MTHFR C677T Polymorphism is Associated with Tumor Response to Preoperative Chemoradiotherapy: A Result Based on Previous Reports.
Author:	Zhao, Yue\|Li, Xingde\|Kong, Xiangjun
PMID:	26456456

267.
Journal:	Mutat Res. 2015 Dec;782:1-6.
Title:	Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk.
Author:	Ho, Vikki\|Ashbury, Janet E\|Taylor, Sherryl\|Vanner, Stephen\|King, Will D
PMID:	26485042

268.
Journal:	Pathol Res Pract. 2015 Dec;211(12):989-95.
Title:	MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer.
Author:	Delgado-Plasencia, Luciano\|Alvarez-Arguelles, Hugo\|Salido-Ruiz, Eduardo\|Castro-Peraza, M Elisa\|Bravo-Gutierrez, Alberto\|Fernandez-Peralta, Antonia\|Gonzalez-Aguilera, Juan\|Alarco-Hernandez, Antonio\|Medina-Arana, Vicente
PMID:	26564107

269.
Journal:	BBA Clin. 2015 Jan 5;3:107-12.
Title:	Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence.
Author:	Lucock, Mark\|Yates, Zoe\|Martin, Charlotte\|Choi, Jeong-Hwa\|Beckett, Emma\|Boyd, Lyndell\|LeGras, Kathleen\|Ng, Xiaowei\|Skinner, Virginia\|Wai, Ron\|Kho, Jeremy\|Roach, Paul\|Veysey, Martin
PMID:	26673393

270.
Journal:	BBA Clin. 2015 Jul 7;4:45-51.
Title:	Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker.
Author:	Beckett, Emma Louise\|Martin, Charlotte\|Choi, Jeong Hwa\|King, Katrina\|Niblett, Suzanne\|Boyd, Lyndell\|Duesing, Konsta\|Yates, Zoe\|Veysey, Martin\|Lucock, Mark
PMID:	26674922

271.
Journal:	Am J Cancer Res. 2015 Sep 15;5(10):3231-40. eCollection 2015.
Title:	A common variant in MTHFR influences response to chemoradiotherapy and recurrence of rectal cancer.
Author:	Nikas, Jason B\|Lee, Janet T\|Maring, Elizabeth D\|Washechek-Aletto, Jill\|Felmlee-Devine, Donna\|Johnson, Ruth A\|Smyrk, Thomas C\|Tawadros, Patrick S\|Boardman, Lisa A\|Steer, Clifford J
PMID:	26693073

272.
Journal:	Asian Pac J Cancer Prev. 2015;16(18):8093-100.
Title:	Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations.
Author:	Rai, Vandana
PMID:	26745044

273.
Journal:	Pharmacogenomics J. 2016 Apr;16(2):173-9.
Title:	A subset of genetic susceptibility variants for colorectal cancer also has prognostic value.
Author:	Noci, S\|Dugo, M\|Bertola, F\|Melotti, F\|Vannelli, A\|Dragani, T A\|Galvan, A
PMID:	25963333

274.
Journal:	Pharmacogenomics J. 2016 Jun;16(3):249-65.
Title:	Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis.
Author:	Salnikova, L E\|Kolobkov, D S
PMID:	26122021

275.
Journal:	Mol Genet Genomics. 2016 Feb;291(1):51-63.
Title:	Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case-control studies.
Author:	Zhu, Xin-Li\|Liu, Zhi-Zhong\|Yan, Sen-Xiang\|Wang, Wei\|Chang, Rui-Xia\|Zhang, Chun-Yan\|Guo, Yan
PMID:	26156333

276.
Journal:	Int J Epidemiol. 2016 Feb;45(1):186-205.
Title:	Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.
Author:	Montazeri, Zahra\|Theodoratou, Evropi\|Nyiraneza, Christine\|Timofeeva, Maria\|Chen, Wanjing\|Svinti, Victoria\|Sivakumaran, Shanya\|Gresham, Gillian\|Cubitt, Laura\|Carvajal-Carmona, Luis\|Bertagnolli, Monica M\|Zauber, Ann G\|Tomlinson, Ian\|Farrington, Susan M\|Dunl
PMID:	26451011

277.
Journal:	Biol Res Nurs. 2016 Jul;18(4):357-69.
Title:	Meta-Prediction of MTHFR Gene Polymorphism Mutations and Associated Risk for Colorectal Cancer.
Author:	Shiao, S P K\|Yu, C H
PMID:	26858257

278.
Journal:	Exp Ther Med. 2016 Jan;11(1):201-207.
Title:	Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature.
Author:	Lin, L I\|Xu, Chun-Wei\|Zhang, B O\|Liu, Rong-Rui\|Ge, Fei-Jiao\|Zhao, Chuan-Hua\|Jia, R U\|Qin, Quan-Hong\|Stojsic, Jelena\|Wang, Yan\|Xu, Jian-Ming
PMID:	26889240

279.
Journal:	Aust Fam Physician. 2016 Apr;45(4):237-40.
Title:	MTHFR genetic testing: Controversy and clinical implications.
Author:	Long, Sarah\|Goldblatt, Jack
PMID:	27052143

280.
Journal:	Environ Mol Mutagen. 2016 May;57(4):261-8.
Title:	Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.
Author:	Ho, Vikki\|Ashbury, Janet E\|Taylor, Sherryl\|Vanner, Stephen\|King, Will D
PMID:	27062459

281.
Journal:	Int J Mol Sci. 2016 Sep 5;17(9). pii: ijms17091482.
Title:	Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients.
Author:	Dreussi, Eva\|Cecchin, Erika\|Polesel, Jerry\|Canzonieri, Vincenzo\|Agostini, Marco\|Boso, Caterina\|Belluco, Claudio\|Buonadonna, Angela\|Lonardi, Sara\|Bergamo, Francesca\|Gagno, Sara\|De Mattia, Elena\|Pucciarelli, Salvatore\|De Paoli, Antonino\|Toffoli, Giuseppe
PMID:	27608007

282.
Journal:	PLoS One. 2016 Sep 29;11(9):e0163961.
Title:	Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines.
Author:	Tsukihara, Hiroshi\|Tsunekuni, Kenta\|Takechi, Teiji
PMID:	27685866

283.
Journal:	Pharmacogenomics. 2016 Oct 28.
Title:	MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case-control study and meta-analysis.
Author:	Haerian, Monir Sadat\|Haerian, Batoul Sadat\|Molanaei, Saadat\|Kosari, Farid\|Sabeti, Shahram\|Bidari-Zerehpoosh, Farahnaz\|Abdolali, Ebrahim\|Zali, Mohammad Reza
PMID:	27790938

284.
Journal:	Crit Rev Oncol Hematol. 2016 Nov;107:72-81.
Title:	Involvement of genetic factors and lifestyle on the occurrence of colorectal and gastric cancer.
Author:	Baroudi, Olfa\|Benammar-Elgaaied, Amel
PMID:	27823653

285.
Journal:	Sci Rep. 2016 Nov 9;6:36607.
Title:	Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study.
Author:	Svensson, Thomas\|Yamaji, Taiki\|Budhathoki, Sanjeev\|Hidaka, Akihisa\|Iwasaki, Motoki\|Sawada, Norie\|Inoue, Manami\|Sasazuki, Shizuka\|Shimazu, Taichi\|Tsugane, Shoichiro
PMID:	27827401

286.
Journal:	J BUON. 2016 Sept-Oct;21(5):1287-1295.
Title:	Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Author:	Cavic, Milena\|Krivokuca, Ana\|Boljevic, Ivana\|Brotto, Ksenija\|Jovanovic, Katarina\|Tanic, Miljana\|Filipovic, Lana\|Zec, Manja\|Malisic, Emina\|Jankovic, Radmila\|Radulovic, Sinisa
PMID:	27837635

287.
Journal:	Anticancer Drugs. 2017 Mar;28(3):322-326.
Title:	5-Fluorouracil degradation rate could predict toxicity in stages II-III colorectal cancer patients undergoing adjuvant FOLFOX.
Author:	Onesti, Concetta E\|Botticelli, Andrea\|La Torre, Marco\|Borro, Marina\|Gentile, Giovanna\|Romiti, Adriana\|Lionetto, Luana\|Petremolo, Antonella\|Occhipinti, Mario\|Roberto, Michela\|Falcone, Rosa\|Simmaco, Maurizio\|Marchetti, Paolo\|Mazzuca, Federica
PMID:	27845948

288.
Journal:	Int J Clin Oncol. 2017 Jun;22(3):484-493.
Title:	Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.
Author:	Yeh, Chih-Ching\|Lai, Ching-Yu\|Chang, Shih-Ni\|Hsieh, Ling-Ling\|Tang, Reiping\|Sung, Fung-Chang\|Lin, Yi-Kuei
PMID:	28044213

289.
Journal:	Anticancer Drugs. 2017 Jun;28(5):551-556.
Title:	A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient.
Author:	Botticelli, Andrea\|Onesti, Concetta E\|Strigari, Lidia\|Occhipinti, Mario\|Di Pietro, Francesca R\|Cerbelli, Bruna\|Petremolo, Antonella\|Anselmi, Elisabetta\|Macrini, Serena\|Roberto, Michela\|Falcone, Rosa\|Lionetto, Luana\|Borro, Marina\|Milano, Annalisa\|Gentile,
PMID:	28296649

290.
Journal:	Clin Lab. 2017 Apr 1;63(4):647-658.
Title:	Colorectal Cancer Carcinogenesis: a Multivariate Genetic Model in a Cohort of Romanian Population.
Author:	Procopciuc, Lucia M\|Osian, Gelu\|Iancu, Mihaela
PMID:	28397463

291.
Journal:	Pharmacogenomics. 2017 Jul;18(11):1075-1084.
Title:	MTRR rs1801394 and its interaction with MTHFR rs1801133 in colorectal cancer: a case-control study and meta-analysis.
Author:	Haerian, Monir Sadat\|Haerian, Batoul Sadat\|Molanaei, Saadat\|Kosari, Farid\|Sabeti, Shahram\|Bidari-Zerehpoosh, Farahnaz\|Abdolali, Ebrahim
PMID:	28691890

292.
Journal:	Oncol Lett. 2017 Aug;14(2):2491-2498.
Title:	Role of depth of response and MTHFR genotype as predictors of fluorouracil rechallenge therapy for refractory metastatic colorectal cancer.
Author:	Kim, Ka-Rham\|Yoon, Jung-Hwan\|Shim, Hyun-Jeong\|Hwang, Jun-Eul\|Bae, Woo-Kyun\|Chung, Ik-Joo\|Kim, Hee-Nam\|Shin, Min-Ho\|Cho, Sang-Hee
PMID:	28781687

293.
Journal:	PLoS One. 2017 Oct 2;12(10):e0185792.
Title:	One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.
Author:	Moruzzi, Sara\|Guarini, Patrizia\|Udali, Silvia\|Ruzzenente, Andrea\|Guglielmi, Alfredo\|Conci, Simone\|Pattini, Patrizia\|Martinelli, Nicola\|Olivieri, Oliviero\|Tammen, Stephanie A\|Choi, Sang-Woon\|Friso, Simonetta
PMID:	28968444

294.
Journal:	Oncotarget. 2017 Jun 29;8(38):63518-63527.
Title:	Investigation of methylenetetrahydrofolate reductase tagging polymorphisms with colorectal cancer in Chinese Han population.
Author:	Zhang, Sheng\|Chen, Shuchen\|Chen, Yu\|Kang, Mingqiang\|Liu, Chao\|Qiu, Hao\|Wang, Yafeng\|Tang, Weifeng
PMID:	28969008

295.
Journal:	Biosci Rep. 2017 Dec 7;37(6). pii: BSR20170917.
Title:	Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis.
Author:	Xu, Lingyan\|Qin, Zhiqiang\|Wang, Feng\|Si, Shuhui\|Li, Lele\|Lin, Peinan\|Han, Xiao\|Cai, Xiaomin\|Yang, Haiwei\|Gu, Yanhong
PMID:	29089462

296.
Journal:	Acta Med Iran. 2017 Dec;55(12):751-758.
Title:	The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells.
Author:	Naghibalhossaini, Fakhraddin\|Shefaghat, Marzieh\|Mansouri, Amirata\|Jaberi, Hajar\|Tatar, Mohsen\|Eftekhar, Ebrahim
PMID:	29373881

297.
Journal:	Cancer Chemother Pharmacol. 2018 Jan;81(1):119-129.
Title:	*DPYD2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.**
Author:	Nahid, Noor Ahmed\|Apu, Mohd Nazmul Hasan\|Islam, Md Reazul\|Shabnaz, Samia\|Chowdhury, Surid Mohammad\|Ahmed, Maizbha Uddin\|Nahar, Zabun\|Islam, Md Siddiqul\|Islam, Mohammad Safiqul\|Hasnat, Abul
PMID:	29134491

298.
Journal:	J Pers Med. 2018 Feb 16;8(1). pii: jpm8010010.
Title:	Gene Environment Interactions and Predictors of Colorectal Cancer in Family-Based, Multi-Ethnic Groups.
Author:	Shiao, S Pamela K\|Grayson, James\|Yu, Chong Ho\|Wasek, Brandi\|Bottiglieri, Teodoro
PMID:	29462916

299.
Journal:	Anticancer Res. 2018 Apr;38(4):2001-2006.
Title:	The Role of MTHFR Genotype in Colorectal Cancer Susceptibility in Taiwan.
Author:	Lin, Kuei-Man\|Yang, Mei-Due\|Tsai, Chia-Wen\|Chang, Wen-Shin\|Hsiao, Chieh-Lun\|Jeng, Long-Bin\|Yueh, Te-Cheng\|Lee, Meng-Chih\|Bau, DA-Tian
PMID:	29599316

300.
Journal:	Int J Biol Markers. 2018 May;33(2):180-188.
Title:	Deciphering the potential value of 5-fluorouracil metabolic enzymes in predicting prognosis and treatment response of colorectal cancer patients.
Author:	Gajjar, Kinjal K\|Vora, Hemangini H\|Kobawala, Toral P\|Trivedi, Trupti I\|Ghosh, Nandita R
PMID:	29799355

301.
Journal:	Cancer Chemother Pharmacol. 2018 Aug;82(2):237-243.
Title:	The association of polymorphisms in folate-metabolizing genes with response to adjuvant chemotherapy of colorectal cancer.
Author:	Yousef, Al-Motassem\|Zawiah, Mohammed\|Al-Yacoub, Shorouq\|Kadi, Taha\|Tantawi, Dua' A\|Al-Ramadhani, Hanguin
PMID:	29845393

302.
Journal:	Cancer Med. 2018 May 29.
Title:	Pathway analysis of genetic variants in folate-mediated one-carbon metabolism-related genes and survival in a prospectively followed cohort of colorectal cancer patients.
Author:	Ose, Jennifer\|Botma, Akke\|Balavarca, Yesilda\|Buck, Katharina\|Scherer, Dominique\|Habermann, Nina\|Beyerle, Jolantha\|Pfutze, Katrin\|Seibold, Petra\|Kap, Elisabeth J\|Benner, Axel\|Jansen, Lina\|Butterbach, Katja\|Hoffmeister, Michael\|Brenner, Hermann\|Ulrich, Alex
PMID:	29845757

303.
Journal:	Oncotarget. 2018 May 22;9(39):25681-25697.
Title:	Meta-analysis of homocysteine-related factors on the risk of colorectal cancer.
Author:	Shiao, S Pamela K\|Lie, Amanda\|Yu, Chong Ho
PMID:	29876016

304.
Journal:	Nutrients. 2018 Jun 20;10(6). pii: nu10060795.
Title:	Personalized Nutrition-Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families.
Author:	Shiao, S Pamela K\|Grayson, James\|Lie, Amanda\|Yu, Chong Ho
PMID:	29925788

305.
Journal:	Curr Dev Nutr. 2018 Mar 13;2(5):nzy013.
Title:	Dietary Uridine Decreases Tumorigenesis in the Apc(Min/+) Model of Intestinal Cancer.
Author:	Field, Martha S\|Lan, Xu\|Stover, Denise M\|Stover, Patrick J
PMID:	29955725

306.
Journal:	J Pers Med. 2018 Aug 6;8(3). pii: jpm8030026.
Title:	Gene-Metabolite Interaction in the One Carbon Metabolism Pathway: Predictors of Colorectal Cancer in Multi-Ethnic Families.
Author:	Shiao, S Pamela K\|Grayson, James\|Yu, Chong Ho
PMID:	30082654

307.
Journal:	Oncotarget. 2018 Jul 27;9(58):31291-31301.
Title:	Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis.
Author:	Zhong, Lei\|He, Xia\|Zhang, Yuan\|Chuan, Jun-Lan\|Chen, Min\|Zhu, Shao-Min\|Peng, Qian
PMID:	30131855

308.
Journal:	Drug Metab Pers Ther. 2018 Sep 12.
Title:	Early disease relapse in a patient with colorectal cancer who harbors genetic variants of DPYD, TYMS, MTHFR and DHFR after treatment with 5-fluorouracil-based chemotherapy.
Author:	Zawiah, Mohammed\|Yousef, Al-Motassem\|Kadi, Taha\|Yousef, Mohammed\|Majdalawi, Khalil\|Al-Yacoub, Shorouq\|Al-Hiary, Rasha\|Tantawi, Dua'a\|Mukred, Ramzi\|Ajaj, Abdel Rahman
PMID:	30207288

309.
Journal:	Pharmacol Res. 2018 Sep 11;136:133-139.
Title:	Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan.
Author:	Salvador-Martin, Sara\|Garcia-Gonzalez, Xandra\|Garcia, Maria I\|Blanco, Carolina\|Garcia-Alfonso, Pilar\|Robles, Luis\|Gravalos, Cristina\|Pachon, Vanessa\|Longo, Federico\|Martinez, Virginia\|Sanjurjo-Saez, Maria\|Lopez-Fernandez, Luis A
PMID:	30213564