Primary Site >> Colorectal Cancer
Gene >> MTHFR
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Ref: A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. PMID: 8895734 |
Ref: Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. PMID: 9067278 |
Ref: Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) PMID: 9680386 Ref: A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. PMID: 9886567 |
Ref: MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. PMID: 10064332 Ref: Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas. PMID: 10203598 Ref: Colorectal cancer: molecules and populations. PMID: 10359544 Ref: Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. PMID: 10385141 Ref: The 677C > T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk. PMID: 10464674 Ref: A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. PMID: 10498402 |
Ref: The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T). PMID: 10695265 Ref: Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas. PMID: 10738112 Ref: Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps. PMID: 10794488 Ref: Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. PMID: 11059519 Ref: Associations between family history of cancer and genes coding for metabolizing enzymes (United States). PMID: 11075868 Ref: Sequential analysis of matched dichotomous data from prospective case-control studies. PMID: 11122507 Ref: Diet and prevention of colorectal cancer. PMID: 11122847 Ref: Normal frequencies of the C677T genotypes on the methylenetetrahydrofolate reductase (MTHFR) gene among lymphoproliferative disorders but not in multiple myeloma. PMID: 11342344 |
Ref: Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. PMID: 11181567 Ref: Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. PMID: 11408344 Ref: [677T mutation of the MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results]. PMID: 11464627 Ref: Polymorphisms and colorectal tumor risk. PMID: 11487538 Ref: Relevance of folate metabolism in the pathogenesis of colorectal cancer. PMID: 11528369 Ref: Folate and the risk of colorectal, breast and cervix cancer: the epidemiological evidence. PMID: 11759174 Ref: [Can molecular genetic knowledge from studies of hereditary carcinoma be applied to sporadic colorectal carcinoma?]. PMID: 11824368 Ref: The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression. PMID: 12540022 |
Ref: The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans. PMID: 11781870 Ref: A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. PMID: 11889073 Ref: B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). PMID: 12020105 Ref: Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. PMID: 12042673 Ref: Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines. PMID: 12107847 Ref: Epidemiologic studies of folate and colorectal neoplasia: a review. PMID: 12163691 Ref: Folate status: effects on pathways of colorectal carcinogenesis. PMID: 12163703 Ref: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. PMID: 12419832 Ref: Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). PMID: 12430180 Ref: Low-penetrance genes and their involvement in colorectal cancer susceptibility. PMID: 12433710 Ref: 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. PMID: 12496052 Ref: Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer. PMID: 12716294 |
Ref: Family history of colon cancer: what does it mean and how is it useful? PMID: 12568823 Ref: Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy. PMID: 12576444 Ref: Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability. PMID: 12618331 Ref: Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. PMID: 12730865 Ref: Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. PMID: 12738713 Ref: Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas. PMID: 14578131 Ref: Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations. PMID: 14608109 Ref: Colon cancer and genetic variation in folate metabolism: the clinical bottom line. PMID: 14608111 Ref: Update on cobalamin, folate, and homocysteine. PMID: 14633777 Ref: The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. PMID: 14676107 |
Ref: Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. PMID: 14724163 Ref: Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer. PMID: 14962716 Ref: MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer. PMID: 14973104 Ref: Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. PMID: 14977639 Ref: The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis. PMID: 15033905 Ref: The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. PMID: 15161007 Ref: [A case-control study on the polymorphisms of methylenetetrahydrofolate reductases, drinking interaction and susceptibility in colorectal cancer]. PMID: 15308044 Ref: Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. PMID: 15342443 Ref: Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction. PMID: 15447919 Ref: [Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer risk: a human genomic epidemiologic review]. PMID: 15476336 Ref: [The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours]. PMID: 15520876 Ref: Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea. PMID: 15533596 Ref: Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. PMID: 15546509 Ref: Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. PMID: 15598777 Ref: Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas. PMID: 15598787 Ref: Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients. PMID: 15608557 Ref: Molecular epidemiology of colon cancer. PMID: 20396547 |
Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: Relationship between metabolic enzyme polymorphism and colorectal cancer. PMID: 15637738 Ref: Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. PMID: 15726099 Ref: Antisense inhibition of methylenetetrahydrofolate reductase reduces cancer cell survival in vitro and tumor growth in vivo. PMID: 15756031 Ref: Diets, polymorphisms of methylenetetrahydrofolate reductase, and the susceptibility of colon cancer and rectal cancer. PMID: 15829374 Ref: Folic acid and colorectal cancer prevention: molecular mechanisms and epidemiological evidence (Review). PMID: 15870856 Ref: The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. PMID: 15894672 Ref: [Activity of the National Oncology R&D Consortium in 2004]. PMID: 15902326 Ref: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. PMID: 16006997 Ref: [Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer]. PMID: 16030402 Ref: One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan. PMID: 16051637 Ref: 5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer. PMID: 16103455 Ref: Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma. PMID: 16128738 Ref: MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors. PMID: 16177213 Ref: Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study. PMID: 16217917 Ref: Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. PMID: 16284371 Ref: Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer. PMID: 16317155 Ref: [Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population]. PMID: 16329804 Ref: Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. PMID: 16351505 Ref: Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. PMID: 16365025 |
Ref: Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population. PMID: 16152599 Ref: Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? PMID: 16187112 Ref: DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. PMID: 16421593 Ref: Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy. PMID: 16456808 Ref: Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer. PMID: 16512993 Ref: Low folate levels may protect against colorectal cancer. PMID: 16638790 Ref: Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer. PMID: 16819711 Ref: Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer. PMID: 16866026 Ref: Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia. PMID: 16886608 Ref: Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate? PMID: 16933051 Ref: Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives. PMID: 17000706 Ref: Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene? PMID: 17009149 Ref: A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation. PMID: 17047490 Ref: Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. PMID: 17079455 Ref: Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer. PMID: 17164363 |
Ref: Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer. PMID: 16927418 Ref: Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers. PMID: 16941173 Ref: Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis. PMID: 17089070 Ref: Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma. PMID: 17111187 Ref: MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations. PMID: 17131337 Ref: Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. PMID: 17245555 Ref: MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer. PMID: 17350979 Ref: Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine. PMID: 17355415 Ref: Folate status and risk of colorectal polyps in African Americans. PMID: 17372834 Ref: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. PMID: 17449906 Ref: Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1. PMID: 17465256 Ref: The interactive effect of methyl-group diet and polymorphism of methylenetetrahydrofolate reductase on the risk of colorectal cancer. PMID: 17602711 Ref: Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population. PMID: 17855693 Ref: MTHFR polymorphisms as prognostic factors in sporadic colorectal cancer. PMID: 17925917 Ref: Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study). PMID: 17932361 Ref: Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer. PMID: 18034621 Ref: Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels. PMID: 18039426 |
Ref: Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy. PMID: 17549067 Ref: The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer. PMID: 17700593 Ref: Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake. PMID: 18053312 Ref: Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer. PMID: 18192902 Ref: Dietary vitamin B6 intake and the risk of colorectal cancer. PMID: 18199722 Ref: Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer. PMID: 18205772 Ref: Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients. PMID: 18245544 Ref: ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. PMID: 18267032 Ref: Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial. PMID: 18322814 Ref: Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis. PMID: 18340404 Ref: Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status. PMID: 18595133 Ref: Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer. PMID: 18703816 Ref: Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer. PMID: 18712959 Ref: MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial. PMID: 18768511 Ref: Methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease. PMID: 18804702 Ref: Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. PMID: 18842806 Ref: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. PMID: 18992148 Ref: Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients. PMID: 18996879 Ref: The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. PMID: 19172696 Ref: Association between the 1793G> A MTHFR polymorphism and sporadic colorectal cancer in Iran. PMID: 19256756 Ref: Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk. PMID: 19776626 Ref: Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women. PMID: 21475466 |
Ref: Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. PMID: 19048402 Ref: The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. PMID: 19123462 Ref: MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. PMID: 19156174 Ref: Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice. PMID: 19174418 Ref: A study of the MTHFR gene polymorphism C677T in colorectal cancer. PMID: 19203896 Ref: The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer. PMID: 19326430 Ref: Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer. PMID: 19384296 Ref: Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake. PMID: 19434801 Ref: MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer. PMID: 19465420 Ref: Association of the 677C -->T polymorphism in the MTHFR gene with colorectal cancer in Mexican patients. PMID: 19487547 Ref: Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study. PMID: 19661077 Ref: MTHFR gene polymorphisms and response to chemotherapy in colorectal cancer: a meta-analysis. PMID: 19663673 Ref: Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. PMID: 19843671 Ref: Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. PMID: 19846566 Ref: Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial. PMID: 19858398 Ref: Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals. PMID: 20037199 Ref: Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer. PMID: 20066895 Ref: C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer. PMID: 20076818 |
Ref: Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy. PMID: 19669769 Ref: Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. PMID: 19936946 Ref: One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study. PMID: 20012180 Ref: Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry. PMID: 20056627 Ref: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients. PMID: 20078613 Ref: MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients. PMID: 20193847 Ref: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. PMID: 20381446 Ref: Plasma folate, related genetic variants, and colorectal cancer risk in EPIC. PMID: 20447924 Ref: Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response. PMID: 20504250 Ref: Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population. PMID: 20504332 Ref: Association of methylenetetrahydrofolate reductase gene polymorphisms & colorectal cancer in India. PMID: 20516537 Ref: MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer. PMID: 20549016 Ref: Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors. PMID: 20551579 Ref: [Correlation between C677T and A1298C mutations of the MTHFR gene and therapeutic prognostic elements in colorectal cancer]. PMID: 20726304 Ref: Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. PMID: 20819423 Ref: SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer. PMID: 20920350 Ref: Folate supplementation induces differential dose-dependent modulation of proliferative phenotypes among cancerous and noncancerous oral cell lines in vitro. PMID: 22432562 |
Ref: Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. PMID: 20177420 Ref: Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. PMID: 20368715 Ref: Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls. PMID: 20473868 Ref: Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer. PMID: 20960050 Ref: Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients. PMID: 21109973 Ref: Impact of MTHFR gene C677T polymorphism on Bcl-2 gene methylation and protein expression in colorectal cancer. PMID: 21128871 Ref: 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes. PMID: 21204909 Ref: MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic. PMID: 21211571 Ref: Clotting factor gene polymorphisms and colorectal cancer risk. PMID: 21422408 Ref: Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case-control study. PMID: 21437631 Ref: Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer. PMID: 21438757 Ref: Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women. PMID: 21462086 Ref: Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients. PMID: 21471424 Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. PMID: 21537397 Ref: Relationship between Metabolic Syndrome and MTHFR Polymorphism in Colorectal Cancer. PMID: 21602966 Ref: Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma. PMID: 21603981 Ref: Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population. PMID: 21732284 Ref: Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients. PMID: 21787270 Ref: Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins. PMID: 21819567 Ref: Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers. PMID: 21934341 Ref: Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer. PMID: 22045187 Ref: Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population. PMID: 22194208 |
Ref: X-ray cross-complementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients. PMID: 21167658 Ref: Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea. PMID: 22218157 Ref: Letter to the editor: a meta-analyses of association between polymorphism of MTHFR A1298C and colorectal cancer risk. PMID: 22350268 Ref: Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies. PMID: 22367721 Ref: Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis. PMID: 22388795 Ref: A comparison of approaches for association studies of polymorphisms and colorectal cancer risk. PMID: 22390411 Ref: Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5-fluorouracil-based therapy together with cetuximab-irinotecan. PMID: 22486600 Ref: ERCC1 C118T associates with response to FOLFOX4 chemotherapy in colorectal cancer patients in Han Chinese. PMID: 22567180 Ref: The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer. PMID: 22719222 Ref: MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies. PMID: 22729883 Ref: MTHFR C677T polymorphism and colorectal cancer risk in Asians, a meta-analysis of 21 studies. PMID: 22799306 Ref: Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study. PMID: 22844384 Ref: Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians. PMID: 22890827 Ref: Insulin-like growth factor 2 gene methylation in peripheral blood mononuclear cells of patients with hepatitis C related cirrhosis or hepatocellular carcinoma. PMID: 22902352 Ref: Pharmacogenetic markers of toxicity for chemotherapy in colorectal cancer patients. PMID: 22909207 Ref: Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancer. PMID: 23019048 Ref: Risk factors for rectal cancer and methylenetetrahydrofolate reductase polymorphisms in a population in Northeast Thailand. PMID: 23098510 Ref: Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis. PMID: 23125859 Ref: Predictors of patient uptake of colorectal cancer gene environment risk assessment. PMID: 23194586 Ref: Short-term folate supplementation in physiological doses has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma. PMID: 23328702 |
Ref: Letter to the editor: a meta-analysis of MTHFR C677T polymorphism and colorectal cancer risk in East Asians. PMID: 22576904 Ref: Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. PMID: 22961839 Ref: Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice. PMID: 23001810 Ref: Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer. PMID: 23314736 Ref: Association between MTHFR polymorphisms and overall survival of colorectal cancer patients in Northeast China. PMID: 23392576 Ref: Folate-genetics and colorectal neoplasia: what we know and need to know next. PMID: 23401104 Ref: Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability. PMID: 23422951 Ref: The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies. PMID: 23437053 Ref: MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland. PMID: 23626689 Ref: Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study. PMID: 23893618 Ref: Allele and genotype frequencies of the polymorphic methylenetetrahydrofolate reductase and colorectal cancer among Jordanian population. PMID: 24083702 Ref: The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia. PMID: 24108782 Ref: Polymorphisms of GSTP1, ERCC2 and TS-3'UTR are associated with the clinical outcome of mFOLFOX6 in colorectal cancer patients. PMID: 24137384 Ref: Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients. PMID: 24169962 Ref: Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. PMID: 24289550 Ref: Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta-analysis. PMID: 24649029 |
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