Primary Site >> Colorectal Cancer

Gene >> MTHFD1

Journal: Int J Cancer. 2004 Jul 1;110(4):617-20.
Title: Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study.
Author: Chen, Jia|Kyte, Charles|Valcin, Martin|Chan, Wendy|Wetmur, James G|Selhub, Jacob|Hunter, David J|Ma, Jing
PMID: 15122597
Journal: Br J Cancer. 2006 Feb 27;94(4):593-8.
Title: DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer.
Author: Kawakami, K|Ruszkiewicz, A|Bennett, G|Moore, J|Grieu, F|Watanabe, G|Iacopetta, B
PMID: 16421593
Journal: Carcinogenesis. 2007 Aug;28(8):1672-9. Epub 2007 Apr 21.
Title: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet.
Author: Curtin, Karen|Slattery, Martha L|Ulrich, Cornelia M|Bigler, Jeannette|Levin, Theodore R|Wolff, Roger K|Albertsen, Hans|Potter, John D|Samowitz, Wade S
PMID: 17449906
Journal: Carcinogenesis. 2011 Mar;32(3):427-33.
Title: Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
Author: MacFarlane, Amanda J|Perry, Cheryll A|McEntee, Michael F|Lin, David M|Stover, Patrick J
PMID: 21156972
Journal: Int J Mol Epidemiol Genet. 2011 Jan 1;2(1):1-8. Epub 2010 Nov 5.
Title: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
Author: Curtin, Karen|Ulrich, Cornelia M|Samowitz, Wade S|Wolff, Roger K|Duggan, David J|Makar, Karen W|Caan, Bette J|Slattery, Martha L
PMID: 21537397
Journal: Gan To Kagaku Ryoho. 2011 Nov;38(12):2220-3.
Title: [Prediction of the efficacy of modified FOLFOX6 therapy according to the mRNA levels of thymidylate synthase (TS), excision repair cross-complementing-1 and -2( ERCC-1 and ERCC-2) and methylenetetrahydrofolate dehydrogenase( MTHFD) in the primary lesion o
Author: Ishibashi, Keiichiro|Okada, Norimichi|Tajima, Yusuke|Ishiguro, Toru|Kuwabara, Kouki|Ohsawa, Tomonori|Kumamoto, Kensuke|Tsuji, Yoshitaka|Haga, Norihiro|Iwama, Takeo|Ishida, Hideyuki|Onouchi, Tsuneko|Yakabi, Koji
PMID: 22202336
Journal: Mol Nutr Food Res. 2013 Apr;57(4):721-34.
Title: Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.
Author: Liu, Amy Y|Scherer, Dominique|Poole, Elizabeth|Potter, John D|Curtin, Karen|Makar, Karen|Slattery, Martha L|Caan, Bette J|Ulrich, Cornelia M
PMID: 22961839
Journal: Mol Nutr Food Res. 2013 Apr;57(4):607-27.
Title: Folate-genetics and colorectal neoplasia: what we know and need to know next.
Author: Figueiredo, Jane C|Levine, A Joan|Crott, Jimmy W|Baurley, James|Haile, Robert W
PMID: 23401104
Journal: Genes Chromosomes Cancer. 2013 Oct;52(10):945-53.
Title: Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study.
Author: Ashmore, Joseph H|Lesko, Samuel M|Muscat, Joshua E|Gallagher, Carla J|Berg, Arthur S|Miller, Paige E|Hartman, Terryl J|Lazarus, Philip
PMID: 23893618
Journal: PLoS One. 2013 Jul 19;8(7):e69366.
Title: Association of methylenetetrahydrofolate dehydrogenase 1 polymorphisms with cancer: a meta-analysis.
Author: Zhang, Hongtuan|Ma, Hui|Li, Liang|Zhang, Zhihong|Xu, Yong
PMID: 23894459
Journal: Cancer. 2015 Oct 15;121(20):3684-91.
Title: Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.
Author: Cheng, Ting-Yuan David|Makar, Karen W|Neuhouser, Marian L|Miller, Joshua W|Song, Xiaoling|Brown, Elissa C|Beresford, Shirley A A|Zheng, Yingye|Poole, Elizabeth M|Galbraith, Rachel L|Duggan, David J|Habermann, Nina|Bailey, Lynn B|Maneval, David R|Caudill,
PMID: 26108676
Journal: PLoS One. 2016 Sep 29;11(9):e0163961.
Title: Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines.
Author: Tsukihara, Hiroshi|Tsunekuni, Kenta|Takechi, Teiji
PMID: 27685866
Journal: Mol Carcinog. 2017 Mar;56(3):1030-1040.
Title: Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.
Author: Levesque, Nancy|Christensen, Karen E|Van Der Kraak, Lauren|Best, Ana F|Deng, Liyuan|Caldwell, Don|MacFarlane, Amanda J|Beauchemin, Nicole|Rozen, Rima
PMID: 27597531
Journal: Cancer Chemother Pharmacol. 2017 Jun;79(6):1077-1085.
Title: Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer.
Author: Sadahiro, Sotaro|Suzuki, T|Tanaka, A|Okada, K|Saito, G|Miyakita, H|Ogimi, T|Nagase, H
PMID: 28417167
Journal: PLoS One. 2017 Oct 2;12(10):e0185792.
Title: One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.
Author: Moruzzi, Sara|Guarini, Patrizia|Udali, Silvia|Ruzzenente, Andrea|Guglielmi, Alfredo|Conci, Simone|Pattini, Patrizia|Martinelli, Nicola|Olivieri, Oliviero|Tammen, Stephanie A|Choi, Sang-Woon|Friso, Simonetta
PMID: 28968444