Primary Site >> Colorectal Cancer
Gene >> MTHFD1
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Ref: Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. PMID: 15122597 |
Ref: DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. PMID: 16421593 |
Ref: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. PMID: 17449906 |
Ref: Mthfd1 is a modifier of chemically induced intestinal carcinogenesis. PMID: 21156972 Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. PMID: 21537397 Ref: [Prediction of the efficacy of modified FOLFOX6 therapy according to the mRNA levels of thymidylate synthase (TS), excision repair cross-complementing-1 and -2( ERCC-1 and ERCC-2) and methylenetetrahydrofolate dehydrogenase( MTHFD) in the primary lesion o PMID: 22202336 |
Ref: Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. PMID: 22961839 Ref: Folate-genetics and colorectal neoplasia: what we know and need to know next. PMID: 23401104 Ref: Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study. PMID: 23893618 Ref: Association of methylenetetrahydrofolate dehydrogenase 1 polymorphisms with cancer: a meta-analysis. PMID: 23894459 |
Ref: Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study. PMID: 26108676 |
Ref: Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines. PMID: 27685866 |
Ref: Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors. PMID: 27597531 Ref: Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer. PMID: 28417167 Ref: One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. PMID: 28968444 |