Primary Site >> Biliary tract Cancer

Gene >> MMP2

Journal: Eur J Clin Chem Clin Biochem. 1995 Feb;33(2):65-71.
Title: Expression pattern of matrix metalloproteinases in human liver.
Author: Lichtinghagen, R|Helmbrecht, T|Arndt, B|Boker, K H
PMID: 7632822
Journal: Br J Cancer. 1996 Apr;73(8):972-8.
Title: Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Author: Bramhall, S R|Stamp, G W|Dunn, J|Lemoine, N R|Neoptolemos, J P
PMID: 8611434
Journal: Hepatology. 1996 Jun;23(6):1341-4.
Title: Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors.
Author: Terada, T|Okada, Y|Nakanuma, Y
PMID: 8675149
Journal: Clin Exp Metastasis. 1998 Jan;16(1):74-82.
Title: Hepatocyte growth factor stimulates the invasion of gallbladder carcinoma cell lines in vitro.
Author: Li, H|Shimura, H|Aoki, Y|Date, K|Matsumoto, K|Nakamura, T|Tanaka, M
PMID: 9502079
Journal: World J Gastroenterol. 2002 Dec;8(6):1138-43.
Title: Expression of MMP-2,TIMP-2 protein and the ratio of MMP-2/TIMP-2 in gallbladder carcinoma and their significance.
Author: Fan, Yue-Zu|Zhang, Jing-Tao|Yang, Hu-Chuan|Yang, Yao-Qin
PMID: 12439941
Journal: Kurume Med J. 2004;51(3-4):215-23.
Title: Immunohistochemical expression of matrix metalloproteinases in bile duct cancer tissue.
Author: Sakai, Takenori
PMID: 15682828
Journal: J Exp Clin Cancer Res. 2004 Dec;23(4):599-606.
Title: A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice.
Author: Horiuchi, H|Kawamata, H|Furihata, T|Omotehara, F|Hori, H|Shinagawa, Y|Ohkura, Y|Tachibana, M|Yamazaki, T|Ajiki, T|Kuroda, Y|Fujimori, T
PMID: 15743030
Journal: Hepatobiliary Pancreat Dis Int. 2004 Nov;3(4):599-602.
Title: The ratio of MMP-2 to TIMP-2 in hilar cholangiocarcinoma: a semi-quantitative study.
Author: Xiao, Mei|Zhou, Nin-Xing|Huang, Zhi-Qiang|Lu, Ya-Li|Chen, Ling-Hong|Wang, Dian-Jun|Chang, Wei-Lin
PMID: 15567754
Journal: Zhonghua Zhong Liu Za Zhi. 2004 May;26(5):271-4.
Title: [The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism].
Author: Fan, Yue-zu|Fu, Jin-ye|Zhao, Ze-ming|Chen, Chun-qiu
PMID: 15312360
Journal: Ann Surg. 2004 Jul;240(1):89-94.
Title: Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma.
Author: Jan, Yi-Yin|Yeh, Ta-Sen|Yeh, Jun-Nan|Yang, Horng-Ren|Chen, Miin-Fu
PMID: 15213623
Journal: Am J Gastroenterol. 2004 Jan;99(1):68-75.
Title: Expression of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in intraductal and nonintraductal growth type of cholangiocarcinoma.
Author: Jo Chae, Kwang|Rha, Sun Young|Oh, Bong-Kyeong|Koo, Ja Seung|Kim, Young Joo|Choi, Jinsub|Park, Chanil|Park, Young Nyun
PMID: 14687144
Journal: World J Gastroenterol. 2005 Apr 28;11(16):2431-7.
Title: Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells.
Author: Fan, Yue-Zu|Fu, Jin-Ye|Zhao, Ze-Ming|Chen, Cun-Qiu
PMID: 15832413
Journal: Zhonghua Wai Ke Za Zhi. 2006 May 1;44(9):618-22.
Title: [Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo].
Author: Fan, Yue-zu|Zhao, Ze-ming|Fu, Jin-ye|Chen, Chun-qiu
PMID: 16784656
Journal: Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):148-52.
Title: Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis.
Author: Karadag, Nese|Kirimlioglu, Hale|Isik, Burak|Yilmaz, Sezai|Kirimlioglu, Vedat
PMID: 18227728
Journal: Hum Pathol. 2008 May;39(5):710-9.
Title: Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts.
Author: Itatsu, Keita|Zen, Yoh|Yamaguchi, Junpei|Ohira, Shusaku|Ishikawa, Akira|Ikeda, Hiroko|Sato, Yasunori|Harada, Kenichi|Sasaki, Motoko|Sasaki, Masatoshi|Sakamoto, Hiroya|Nagino, Masato|Nimura, Yuji|Ohta, Tetsuo|Nakanuma, Yasuni
PMID: 18329694
Journal: Anticancer Res. 2008 May-Jun;28(3B):1875-81.
Title: The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters.
Author: Giannopoulos, George|Pavlakis, Kitty|Parasi, Aikaterini|Kavatzas, Nikolaos|Tiniakos, Dina|Karakosta, Antigoni|Tzanakis, Nikolaos|Peros, George
PMID: 18630474
Journal: Med Oncol. 2009;26(2):117-23.
Title: Prediction of prognosis in gallbladder carcinoma by CD147 and MMP-2 immunohistochemistry.
Author: Wu, Wei|Wang, Rongbing|Liu, Hui|Peng, Jie|Huang, Damao|Li, Bo|Ruan, Jingde
PMID: 18665467
Journal: Lab Invest. 2009 Nov;89(11):1261-74.
Title: Fascin is involved in tumor necrosis factor-alpha-dependent production of MMP9 in cholangiocarcinoma.
Author: Onodera, Manabu|Zen, Yoh|Harada, Kenichi|Sato, Yasunori|Ikeda, Hiroko|Itatsu, Keita|Sato, Hiroshi|Ohta, Tetsuo|Asaka, Masahiro|Nakanuma, Yasuni
PMID: 19721413
Journal: Turk J Gastroenterol. 2009 Mar;20(1):41-7.
Title: The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression
Author: Kirimlioglu, Hale|Turkmen, Ilknur|Bassullu, Nuray|Dirican, Abuzer|Karadag, Nese|Kirimlioglu, Vedat
PMID: 19330734
Journal: Pathol Oncol Res. 2010 Mar;16(1):47-53.
Title: Expression of matrix metalloproteinase 2 and extracellular matrix metalloproteinase inducer are unfavorable postoperative prognostic factors in intrahepatic cholangiocarcinoma.
Author: Zhang, Che|Tu, Ziliang|Du, Shiming|Wang, Yong|Wang, Qibin
PMID: 19629755
Journal: World J Gastroenterol. 2010 Feb 14;16(6):713-22.
Title: Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion.
Author: Menakongka, Apaporn|Suthiphongchai, Tuangporn
PMID: 20135719
Journal: Cancer Sci. 2010 Aug;101(8):1913-9.
Title: Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma.
Author: Hasita, Horlad|Komohara, Yoshihiro|Okabe, Hirohisa|Masuda, Toshiro|Ohnishi, Koji|Lei, Xiao F|Beppu, Toru|Baba, Hideo|Takeya, Motohiro
PMID: 20545696
Journal: Hepatogastroenterology. 2010 Mar-Apr;57(98):207-11.
Title: Expression of LAPTM4B in gallbladder carcinoma cells: the role in invasive potential.
Author: Zhou, Li|He, Xiao-Dong|Yu, Jian-Chun|Zhou, Rou-Li|Xiong, Fu-Xia|Qu, Qiang|Rui, Jing-An
PMID: 20583413
Journal: J Gastroenterol. 2011 May;46(5):664-75.
Title: Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
Author: Namwat, N|Puetkasichonpasutha, J|Loilome, W|Yongvanit, P|Techasen, A|Puapairoj, A|Sripa, B|Tassaneeyakul, W|Khuntikeo, N|Wongkham, S
PMID: 21076843
Journal: Oncol Rep. 2012 Mar;27(3):775-82.
Title: Establishment and characterization of a cell line, EH-GB2, derived from hepatic metastasis of gallbladder cancer.
Author: Wang, Jing-Han|Li, Lin-Fang|Yu, Yong|Li, Bin|Jin, Hua-Jun|Shen, Dong-Hao|Li, Jiang|Jiang, Xiao-Qing|Qian, Qi-Jun
PMID: 22134783
Journal: Liver Int. 2012 Sep;32(8):1278-86.
Title: Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer.
Author: Sharma, Kiran L|Misra, Sanjeev|Kumar, Ashok|Mittal, Balraj
PMID: 22621753
Journal: Asian Pac J Cancer Prev. 2012;13 Suppl:149-54.
Title: Cepharanthine suppresses metastatic potential of human cholangiocarcinoma cell lines.
Author: Uthaisar, Kwuntida|Seubwai, Wunchana|Srikoon, Pattravedee|Vaeteewoottacharn, Kulthida|Sawanyawisuth, Kanlayanee|Okada, Seiji|Wongkham, Sopit
PMID: 23480757
Journal: Asian Pac J Cancer Prev. 2012;13 Suppl:155-60.
Title: TNP-470, a methionine aminopeptidase-2 inhibitor, inhibits cell proliferation, migration and invasion of human cholangiocarcinoma cells in vitro.
Author: Kidoikhammouan, Sonexai|Seubwai, Wunchana|Tantapotinan, Nattawat|Silsirivanit, Atit|Wongkham, Sopit|Sawanyawisuth, Kanlayanee|Wongkham, Chaisiri
PMID: 23480758
Journal: PLoS One. 2013 Oct 17;8(10):e77623.
Title: miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells.
Author: Okamoto, Kinya|Miyoshi, Kenichi|Murawaki, Yoshikazu
PMID: 24147037
Journal: PLoS One. 2013;8(1):e54619.
Title: Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.
Author: Zhang, Chi|Bai, Dou-Sheng|Huang, Xiao-Yong|Shi, Guo-Ming|Ke, Ai-Wu|Yang, Liu-Xiao|Yang, Xin-Rong|Zhou, Jian|Fan, Jia
PMID: 23349941
Journal: Cancer Sci. 2013 Nov;104(11):1427-32.
Title: Forkhead box protein C2 contributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis.
Author: Watanabe, Akira|Suzuki, Hideki|Yokobori, Takehiko|Altan, Bolag|Kubo, Norio|Araki, Kenichiro|Wada, Satoshi|Mochida, Yasushi|Sasaki, Shigeru|Kashiwabara, Kenji|Hosouchi, Yasuo|Kuwano, Hiroyuki
PMID: 23919841
Journal: World J Gastroenterol. 2013 Apr 28;19(16):2456-65.
Title: Annexin A1: A new immunohistological marker of cholangiocarcinoma.
Author: Hongsrichan, Nuttanan|Rucksaken, Rucksak|Chamgramol, Yaovalux|Pinlaor, Porntip|Techasen, Anchalee|Yongvanit, Puangrat|Khuntikeo, Narong|Pairojkul, Chawalit|Pinlaor, Somchai
PMID: 23674846
Journal: PLoS One. 2013;8(1):e54377.
Title: Characterization of two novel cell lines with distinct heterogeneity derived from a single human bile duct carcinoma.
Author: Wang, Jinghan|Li, Linfang|Zhang, Keqiang|Yu, Yong|Li, Bin|Li, Jiang|Yan, Zi|Hu, Zhenli|Yen, Yun|Wu, Mengchao|Jiang, Xiaoqing|Qian, Qijun
PMID: 23382894
Journal: Clin Exp Metastasis. 2013 Feb;30(2):177-87.
Title: Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma.
Author: Hong, Sun Mi|Park, Chang Wook|Cha, Hyung Jin|Kwon, Jung Hee|Yun, Young Sung|Lee, Nam Gyu|Kim, Dae-Ghon|Nam, Hong Gil|Choi, Kwan Yong
PMID: 22875246
Journal: Int J Oncol. 2013 Jun;42(6):2103-15.
Title: Contribution of the PI3K/MMPs/Ln-5gamma2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.
Author: Lu, Xin-Sui|Sun, Wei|Ge, Chun-Yan|Zhang, Wen-Zhong|Fan, Yue-Zu
PMID: 23588386
Journal: Cancer Sci. 2014 Mar;105(3):272-80.
Title: Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer.
Author: Matsushita, Shojiro|Onishi, Hideya|Nakano, Kenji|Nagamatsu, Iori|Imaizumi, Akira|Hattori, Masami|Oda, Yoshinao|Tanaka, Masao|Katano, Mitsuo
PMID: 24438533
Journal: BMC Cancer. 2014 Mar 15;14:193.
Title: Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5gamma2 signaling pathway.
Author: Zhang, Jing-Tao|Sun, Wei|Zhang, Wen-Zhong|Ge, Chun-Yan|Liu, Zhong-Yan|Zhao, Ze-Ming|Lu, Xing-Sui|Fan, Yue-Zu
PMID: 24628713
Journal: Tumour Biol. 2014 Sep;35(9):8597-606.
Title: A multigenic approach to evaluate genetic variants of PLCE1, LXRs, MMPs, TIMP, and CYP genes in gallbladder cancer predisposition.
Author: Sharma, Kiran Lata|Rai, Rajani|Srivastava, Anshika|Sharma, Aarti|Misra, Sanjeev|Kumar, Ashok|Mittal, Balraj
PMID: 24863943
Journal: Oncol Rep. 2015 Apr;33(4):1683-90.
Title: Maslinic acid potentiates the antitumor activities of gemcitabine in vitro and in vivo by inhibiting NF-kappaB-mediated survival signaling pathways in human gallbladder cancer cells.
Author: Yu, Yong|Wang, Jinghan|Xia, Nianxin|Li, Bin|Jiang, Xiaoqing
PMID: 25633045
Journal: BMC Cancer. 2015 Nov 16;15:903.
Title: Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44nu is an indicator for recurrence in advanced cancer.
Author: Wu, Cheng-Lin|Chao, Ying-Jui|Yang, Ta-Ming|Chen, Yi-Ling|Chang, Kung-Chao|Hsu, Hui-Ping|Shan, Yan-Shen|Lai, Ming-Derg
PMID: 26572077
Journal: Biochem Biophys Res Commun. 2015 Mar 6;458(2):234-9.
Title: Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma.
Author: Ma, Chao|Peng, Chunyan|Lu, Xuejia|Ding, Xiwei|Zhang, Shu|Zou, Xiaoping|Zhang, Xiaoqi
PMID: 25623530
Journal: Int J Oncol. 2015 Feb;46(2):627-40.
Title: Norcantharidin enhances TIMP2 antivasculogenic mimicry activity for human gallbladder cancers through downregulating MMP2 and MT1MMP.
Author: Zhu, Wei|Sun, Wei|Zhang, Jing-Tao|Liu, Zhong-Yan|Li, Xin-Ping|Fan, Yue-Zu
PMID: 25405519
Journal: Tumour Biol. 2016 Mar;37(3):4159-67.
Title: SPARCL1 is a novel predictor of tumor recurrence and survival in hilar cholangiocarcinoma.
Author: Yu, Yang|Chen, Yan|Ma, Jianxia|Yu, Xiaofeng|Yu, Guanzhen|Li, Zhaoshen
PMID: 26490986
Journal: Mol Med Rep. 2016 Jun;13(6):5255-61.
Title: Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition.
Author: Yang, Haixia|Liang, Jun|Zhou, Jiupeng|Mi, Jianqiang|Ma, Ke|Fan, Yangwei|Ning, Jing|Wang, Chuying|Wei, Xin|Li, Enxiao
PMID: 27108649
Journal: Cancer Invest. 2016 Jul 2;34(6):255-64.
Title: SHP2 and UGP2 are Biomarkers for Progression and Poor Prognosis of Gallbladder Cancer.
Author: Wang, Qunwei|Yang, Zhu-Lin|Zou, Qiong|Yuan, Yuan|Li, Jinghe|Liang, Lufeng|Zeng, Guixiang|Chen, Senlin
PMID: 27389087
Journal: Oncotarget. 2017 Feb 14;8(7):12133-12144.
Title: DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer.
Author: Shen, Jiliang|Zhou, Senjun|Shi, Liang|Liu, Xiaolong|Lin, Hui|Yu, Hong|Xiaoliang|Tang, Jiacheng|Yu, Tunan|Cai, Xiujun
PMID: 28129656
Journal: Hepatol Commun. 2017 Oct 25;1(10):1099-1109.
Title: Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma.
Author: Mino, Masaaki|Kanno, Keishi|Okimoto, Kousuke|Sugiyama, Akiko|Kishikawa, Nobusuke|Kobayashi, Tomoki|Ono, Junya|Izuhara, Kenji|Kobayashi, Tsuyoshi|Ohigashi, Toshikazu|Ohdan, Hideki|Tazuma, Susumu
PMID: 29404445
Journal: Oncotarget. 2017 May 23;8(34):56672-56683.
Title: Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma.
Author: Liu, Sulai|Jiang, Bo|Li, Hao|He, Zili|Lv, Pin|Peng, Chuang|Wang, Yonggang|Cheng, Wei|Xu, Zhengquan|Chen, Wei|Liu, Zhengkai|Zhang, Bao|Shen, Shengqian|Xiang, Shuanglin
PMID: 28915621
Journal: Cell Physiol Biochem. 2017;42(1):222-230.
Title: Long Noncoding RNA AFAP1-AS1 Promoted Tumor Growth and Invasion in Cholangiocarcinoma.
Author: Lu, Xu|Zhou, Chuang|Li, Renfeng|Deng, Yilei|Zhao, Longshuan|Zhai, Wenlong
PMID: 28535506
Journal: Cancer Biomark. 2017 Jul 4;19(3):313-325.
Title: 14-3-3sigma downregulation suppresses ICC metastasis via impairing migration, invasion, and anoikis resistance of ICC cells.
Author: Yang, Zhenjie|Jin, Qianjun|Hu, Wendi|Dai, Longfei|Xue, Zhengze|Man, Da|Zhou, Lin|Xie, Haiyang|Wu, Jian|Zheng, Shusen
PMID: 28482619
Journal: Oncol Lett. 2017 Mar;13(3):1660-1664.
Title: Inhibitory effect of norcantharidin on melanoma tumor growth and vasculogenic mimicry by suppressing MMP-2 expression.
Author: Wang, Zhenyu|You, Dingyun|Lu, Minnan|He, Yuefeng|Yan, Shan
PMID: 28454306
Journal: Oncotarget. 2017 May 30;8(22):36211-36224.
Title: Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer.
Author: Kawamoto, Makoto|Onishi, Hideya|Ozono, Keigo|Yamasaki, Akio|Imaizumi, Akira|Kamakura, Sachiko|Nakano, Kenji|Oda, Yoshinao|Sumimoto, Hideki|Nakamura, Masafumi
PMID: 28423707
Journal: Cytotechnology. 2018 Feb;70(1):83-94.
Title: Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway.
Author: Qian, Liqiang|Li, Xiaqin|Ye, Penghui|Wang, Gang|Dai, Wei|Liu, Yan|Gao, Quangen|Shen, Genhai
PMID: 29170841
Journal: Mol Med Rep. 2018 Jun;17(6):7672-7682.
Title: Role of cantharidin in the activation of IKKalpha/IkappaBalpha/NFkappaB pathway by inhibiting PP2A activity in cholangiocarcinoma cell lines.
Author: Zhou, Huijiang|Xu, Jiangfeng|Wang, Shuai|Peng, Jinfeng
PMID: 29620225
Journal: Biomed Res Int. 2018 Feb 22;2018:8182575.
Title: Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity.
Author: Shuang, Zeyu|Mao, Yize|Lin, Guohe|Wang, Jun|Huang, Xin|Chen, Jianlin|Duan, Fangting|Li, Shengping
PMID: 29682557
Journal: Biomed Pharmacother. 2018 Jul;103:1272-1278.
Title: Knockdown of TRIM31 suppresses proliferation and invasion of gallbladder cancer cells by down-regulating MMP2/9 through the PI3K/Akt signaling pathway.
Author: Li, Hui|Zhang, Yu|Hai, Jun|Wang, Jixin|Zhao, Bei|Du, Lixue|Geng, Xilin
PMID: 29864908
Journal: Pharmazie. 2018 Jul 1;73(7):413-417.
Title: Anti-proliferative and anti-invasive effects of garcinol from Garcinia indica on gallbladder carcinoma cells.
Author: Duan, Yi-Tao|Yang, Xiao-Ang|Fang, Lian-Ying|Wang, Jin-Han|Liu, Qiang
PMID: 30001777
Journal: Oncol Lett. 2018 Aug;16(2):1841-1848.
Title: Inhibiting the proliferation and metastasis of hilar cholangiocarcinoma cells by blocking the expression of vascular endothelial growth factor with small interfering RNA.
Author: Xiao, Ke|Ouyang, Zhengxiao|Tang, Hui-Huan
PMID: 30008874