Primary Site >> Biliary tract Cancer
Gene >> MLH1
| 1. | |||||||||||
| Journal: | Anticancer Res. 1999 May-Jun;19(3A):1765-8. | ||||||||||
| Title: | Analysis of microsatellite instability, TGF-beta type II receptor gene mutations and hMSH2 and hMLH1 allele losses in pancreaticobiliary maljunction-associated biliary tract tumors. | ||||||||||
| Author: | Nagai, M|Kawarada, Y|Watanabe, M|Iwase, T|Muneyuki, T|Yamao, K|Fukutome, K|Yatani, R | ||||||||||
| PMID: | 10470113 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Cancer. 2000 Oct 15;88(2):228-31. | ||||||||||
| Title: | Allelic loss in human intrahepatic cholangiocarcinoma: correlation between chromosome 8p22 and tumor progression. | ||||||||||
| Author: | Kawaki, J|Miyazaki, M|Ito, H|Nakagawa, K|Shimizu, H|Yoshidome, H|Uzawa, K|Tanzawa, H|Nakajima, N | ||||||||||
| PMID: | 11004673 | ||||||||||
| 3. | |||||||||||
| Journal: | Ann Chir Gynaecol. 2000;89(3):207-10. | ||||||||||
| Title: | Surveillance on mutation carriers of DNA mismatch repair genes. | ||||||||||
| Author: | Jarvinen, H J|Aarnio, M | ||||||||||
| PMID: | 11079789 | ||||||||||
| 4. | |||||||||||
| Journal: | J Surg Oncol. 2001 Feb;76(2):121-6. | ||||||||||
| Title: | Infrequent microsatellite instability in biliary tract cancer. | ||||||||||
| Author: | Suto, T|Habano, W|Sugai, T|Uesugi, N|Kanno, S|Saito, K|Nakamura, S | ||||||||||
| PMID: | 11223838 | ||||||||||
| 5. | |||||||||||
| Journal: | Int J Cancer. 2002 Apr 10;98(5):774-9. | ||||||||||
| Title: | Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain. | ||||||||||
| Author: | Caldes, Trinidad|Godino, Javier|de la Hoya, Miguel|Garcia Carbonero, Iciar|Perez Segura, Pedro|Eng, Charis|Benito, Manuel|Diaz-Rubio, Eduardo | ||||||||||
| PMID: | 11920650 | ||||||||||
| 6. | |||||||||||
| Journal: | Ann Surg Oncol. 2002 May;9(4):371-9. | ||||||||||
| Title: | Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. | ||||||||||
| Author: | Kohya, Naohiko|Miyazaki, Kohji|Matsukura, Shiroh|Yakushiji, Hiroyuki|Kitajima, Yoshihiko|Kitahara, Kenji|Fukuhara, Masao|Nakabeppu, Yusaku|Sekiguchi, Mutsuo | ||||||||||
| PMID: | 11986189 | ||||||||||
| 7. | |||||||||||
| Journal: | Br J Cancer. 2002 Jul 15;87(2):187-93. | ||||||||||
| Title: | Establishment and characterisation of six human biliary tract cancer cell lines. | ||||||||||
| Author: | Ku, J-L|Yoon, K-A|Kim, I-J|Kim, W-H|Jang, J-Y|Suh, K-S|Kim, S-W|Park, Y-H|Hwang, J-H|Yoon, Y-B|Park, J-G | ||||||||||
| PMID: | 12107841 | ||||||||||
| 8. | |||||||||||
| Journal: | Cancer Lett. 2002 Jul 26;181(2):215-22. | ||||||||||
| Title: | Microsatellite alterations in liver fluke related cholangiocarcinoma are associated with poor prognosis. | ||||||||||
| Author: | Limpaiboon, Temduang|Krissadarak, Kamoltip|Sripa, Banchob|Jearanaikoon, Patcharee|Bhuhisawasdi, Vajarabhongsa|Chau-in, Siri|Romphruk, Amornrat|Pairojkul, Chawalit | ||||||||||
| PMID: | 12175538 | ||||||||||
| 9. | |||||||||||
| Journal: | Int J Cancer. 2002 Dec 1;102(4):366-71. | ||||||||||
| Title: | Microsatellite instability in thorotrast-induced human intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Liu, Duo|Momoi, Hirohito|Li, Li|Ishikawa, Yuichi|Fukumoto, Manabu | ||||||||||
| PMID: | 12402306 | ||||||||||
| 10. | |||||||||||
| Journal: | Mod Pathol. 2002 Dec;15(12):1309-17. | ||||||||||
| Title: | Microsatellite instability in intraductal papillary neoplasms of the biliary tract. | ||||||||||
| Author: | Abraham, Susan C|Lee, Jae-Hyuk|Boitnott, John K|Argani, Pedram|Furth, Emma E|Wu, Tsung-Teh | ||||||||||
| PMID: | 12481012 | ||||||||||
| 11. | |||||||||||
| Journal: | Gastroenterology. 2003 May;124(5):1300-10. | ||||||||||
| Title: | Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. | ||||||||||
| Author: | Kim, Sang Geol|Chan, Annie On-On|Wu, Tsung-Teh|Issa, Jean-Pierre J|Hamilton, Stanley R|Rashid, Asif | ||||||||||
| PMID: | 12730870 | ||||||||||
| 12. | |||||||||||
| Journal: | Ann Surg Oncol. 2003 Oct;10(8):882-9. | ||||||||||
| Title: | Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer. | ||||||||||
| Author: | House, Michael G|Wistuba, Ignacio I|Argani, Pedram|Guo, MingZhou|Schulick, Richard D|Hruban, Ralph H|Herman, James G|Maitra, Anirban | ||||||||||
| PMID: | 14527906 | ||||||||||
| 13. | |||||||||||
| Journal: | Pathol Int. 2003 Oct;53(10):667-70. | ||||||||||
| Title: | Lack of microsatellite instability in neoplasms of ampulla of Vater. | ||||||||||
| Author: | Park, Sunhoo|Kim, Sun Whe|Kim, Sun Hee|Darwish, Nevine S|Kim, Woo Ho | ||||||||||
| PMID: | 14516316 | ||||||||||
| 14. | |||||||||||
| Journal: | Int J Cancer. 2003 Nov 10;107(3):375-80. | ||||||||||
| Title: | Infrequent microsatellite instability in liver fluke infection-associated intrahepatic cholangiocarcinomas from Thailand. | ||||||||||
| Author: | Liengswangwong, Upama|Nitta, Takayuki|Kashiwagi, Hironobu|Kikukawa, Hiroko|Kawamoto, Toru|Todoroki, Takeshi|Uchida, Kazuhiko|Khuhaprema, Thiravud|Karalak, Anant|Srivatanakul, Petcharin|Miwa, Masanao | ||||||||||
| PMID: | 14506736 | ||||||||||
| 15. | |||||||||||
| Journal: | Am J Clin Pathol. 2003 Sep;120(3):413-7. | ||||||||||
| Title: | Microsatellite instability in chronic cholecystitis is indicative of an early stage in gallbladder carcinogenesis. | ||||||||||
| Author: | Yanagisawa, Nobuyuki|Mikami, Tetuo|Yamashita, Kazuya|Okayasu, Isao | ||||||||||
| PMID: | 14502806 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Lett. 2003 Sep 25;199(2):131-8. | ||||||||||
| Title: | Expression of Fhit, Mlh1, and P53 protein in human gallbladder carcinoma. | ||||||||||
| Author: | Koda, Masaharu|Yashima, Kazuo|Kawaguchi, Koichirou|Andachi, Hironobu|Hosoda, Akihide|Shiota, Goshi|Ito, Hisao|Murawaki, Yoshikazu | ||||||||||
| PMID: | 12969785 | ||||||||||
| 17. | |||||||||||
| Journal: | Cancer Sci. 2004 Sep;95(9):736-40. | ||||||||||
| Title: | Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients. | ||||||||||
| Author: | Tozawa, Tomohiro|Tamura, Gen|Honda, Teiichiro|Nawata, Shin-ichi|Kimura, Wataru|Makino, Naohiko|Kawata, Sumio|Sugai, Tamotsu|Suto, Takayuki|Motoyama, Teiichi | ||||||||||
| PMID: | 15471559 | ||||||||||
| 18. | |||||||||||
| Journal: | Anticancer Res. 2005 Nov-Dec;25(6B):4021-8. | ||||||||||
| Title: | The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells. | ||||||||||
| Author: | Sato, Ken|Kitajima, Yoshihiko|Koga, Yasuo|Miyazaki, Kohji | ||||||||||
| PMID: | 16309194 | ||||||||||
| 19. | |||||||||||
| Journal: | Ann Surg Oncol. 2005 May;12(5):354-63. Epub 2005 Mar 31. | ||||||||||
| Title: | Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers. | ||||||||||
| Author: | Koga, Yasuo|Kitajima, Yoshihiko|Miyoshi, Atsushi|Sato, Ken|Kitahara, Kenji|Soejima, Hidenobu|Miyazaki, Kohji | ||||||||||
| PMID: | 15915369 | ||||||||||
| 20. | |||||||||||
| Journal: | Int J Oncol. 2005 Jun;26(6):1653-61. | ||||||||||
| Title: | Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest. | ||||||||||
| Author: | Sato, Ken|Kitajima, Yoshihiko|Kohya, Naohiko|Miyoshi, Atsushi|Koga, Yasuo|Miyazaki, Kohji | ||||||||||
| PMID: | 15870882 | ||||||||||
| 21. | |||||||||||
| Journal: | Cancer Lett. 2005 Jan 20;217(2):213-9. | ||||||||||
| Title: | Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma. | ||||||||||
| Author: | Limpaiboon, Temduang|Khaenam, Prasong|Chinnasri, Patcharee|Soonklang, Montisha|Jearanaikoon, Patcharee|Sripa, Banchob|Pairojkul, Chawalit|Bhudhisawasdi, Vajarabhongsa | ||||||||||
| PMID: | 15617839 | ||||||||||
| 22. | |||||||||||
| Journal: | Mod Pathol. 2005 Mar;18(3):412-20. | ||||||||||
| Title: | Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Yang, Bin|House, Michael G|Guo, Mingzhou|Herman, James G|Clark, Douglas P | ||||||||||
| PMID: | 15467712 | ||||||||||
| 23. | |||||||||||
| Journal: | J Gastroenterol. 2005 Jan;40(1):79-86. | ||||||||||
| Title: | Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder. | ||||||||||
| Author: | Roa, Juan Carlos|Roa, Ivan|Correa, Pelayo|Vo, Quynh|Araya, Juan Carlos|Villaseca, Miguel|Guzman, Pablo|Schneider, Barbara G | ||||||||||
| PMID: | 15692793 | ||||||||||
| 24. | |||||||||||
| Journal: | J Gastroenterol. 2006 Mar;41(3):269-75. | ||||||||||
| Title: | Promoter methylation profile in gallbladder cancer. | ||||||||||
| Author: | Roa, Juan Carlos|Anabalon, Leonardo|Roa, Ivan|Melo, Angelica|Araya, Juan Carlos|Tapia, Oscar|de Aretxabala, Xavier|Munoz, Sergio|Schneider, Barbara | ||||||||||
| PMID: | 16699861 | ||||||||||
| 25. | |||||||||||
| Journal: | World J Gastroenterol. 2006 Jun 21;12(23):3740-5. | ||||||||||
| Title: | Immunohistochemical expression of mismatch repair genes: a screening tool for predicting mutator phenotype in liver fluke infection-associated intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Liengswangwong, Upama|Karalak, Anant|Morishita, Yukio|Noguchi, Masayuki|Khuhaprema, Thiravud|Srivatanakul, Petcharin|Miwa, Masanao | ||||||||||
| PMID: | 16773692 | ||||||||||
| 26. | |||||||||||
| Journal: | Cancer Lett. 2007 May 18;250(1):100-6. Epub 2006 Nov 7. | ||||||||||
| Title: | Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma. | ||||||||||
| Author: | Riquelme, Erick|Tang, Moying|Baez, Sergio|Diaz, Alfonso|Pruyas, Martha|Wistuba, Ignacio I|Corvalan, Alejandro | ||||||||||
| PMID: | 17084965 | ||||||||||
| 27. | |||||||||||
| Journal: | Anticancer Res. 2007 Mar-Apr;27(2):865-72. | ||||||||||
| Title: | CPT-11 (SN-38) chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expression. | ||||||||||
| Author: | Sato, Ken|Kitajima, Yoshihiko|Kohya, Naohiko|Koga, Yasuo|Ohtaka, Kazuma|Miyazaki, Kohji | ||||||||||
| PMID: | 17465213 | ||||||||||
| 28. | |||||||||||
| Journal: | Virchows Arch. 2007 Sep;451(3):649-57. Epub 2007 Jul 26. | ||||||||||
| Title: | Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability. | ||||||||||
| Author: | Sessa, Fausto|Furlan, Daniela|Zampatti, Clementina|Carnevali, Ileana|Franzi, Francesca|Capella, Carlo | ||||||||||
| PMID: | 17653761 | ||||||||||
| 29. | |||||||||||
| Journal: | Tumour Biol. 2007;28(5):290-300. Epub 2007 Oct 26. | ||||||||||
| Title: | Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time? | ||||||||||
| Author: | Soreide, Kjetil | ||||||||||
| PMID: | 17962726 | ||||||||||
| 30. | |||||||||||
| Journal: | Rev Med Chil. 2008 Apr;136(4):451-8. | ||||||||||
| Title: | [Gene methylation patterns in digestive tumors]. | ||||||||||
| Author: | Roa S, Juan Carlos|Garcia M, Patricia|Melo A, Angelica|Tapia E, Oscar|Villaseca H, Miguel|Araya O, Juan Carlos|Guzman G, Pablo | ||||||||||
| PMID: | 18769787 | ||||||||||
| 31. | |||||||||||
| Journal: | Am J Surg Pathol. 2009 May;33(5):691-704. | ||||||||||
| Title: | Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. | ||||||||||
| Author: | Ruemmele, Petra|Dietmaier, Wolfgang|Terracciano, Luigi|Tornillo, Luigi|Bataille, Frauke|Kaiser, Annette|Wuensch, Peter-Heinz|Heinmoeller, Ernst|Homayounfar, Kia|Luettges, Jutta|Kloeppel, Guenter|Sessa, Fausto|Edmonston, Tina Bocker|Schneider-Stock, Regine | ||||||||||
| PMID: | 19252434 | ||||||||||
| 32. | |||||||||||
| Journal: | Am J Clin Pathol. 2010 May;133(5):772-80. | ||||||||||
| Title: | DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases. | ||||||||||
| Author: | Agaram, Narasimhan P|Shia, Jinru|Tang, Laura H|Klimstra, David S | ||||||||||
| PMID: | 20395525 | ||||||||||
| 33. | |||||||||||
| Journal: | Appl Immunohistochem Mol Morphol. 2011 Mar;19(2):133-40. | ||||||||||
| Title: | Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. | ||||||||||
| Author: | Pai, Rish K|Mojtahed, Kaveh|Pai, Reetesh K | ||||||||||
| PMID: | 21307665 | ||||||||||
| 34. | |||||||||||
| Journal: | PLoS One. 2012;7(9):e46002. | ||||||||||
| Title: | Irrelevance of microsatellite instability in the epidemiology of sporadic pancreatic ductal adenocarcinoma. | ||||||||||
| Author: | Laghi, Luigi|Beghelli, Stefania|Spinelli, Antonino|Bianchi, Paolo|Basso, Gianluca|Di Caro, Giuseppe|Brecht, Anna|Celesti, Giuseppe|Turri, Giona|Bersani, Samantha|Schumacher, Guido|Rocken, Christoph|Grantzdorffer, Ilona|Roncalli, Massimo|Zerbi, Alessandro| | ||||||||||
| PMID: | 23029359 | ||||||||||
| 35. | |||||||||||
| Journal: | Arch Pathol Lab Med. 2012 Nov;136(11):1347-58. | ||||||||||
| Title: | Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas. | ||||||||||
| Author: | Dursun, Nevra|Escalona, Oscar Tapia|Roa, Juan Carlos|Basturk, Olca|Bagci, Pelin|Cakir, Asli|Cheng, Jeanette|Sarmiento, Juan|Losada, Hector|Kong, So Yeon|Ducato, Leslie|Goodman, Michael|Adsay, N Volkan | ||||||||||
| PMID: | 23106580 | ||||||||||
| 36. | |||||||||||
| Journal: | Ann Surg Oncol. 2013 Aug;20(8):2511-7. | ||||||||||
| Title: | P16 hypermethylation predicts surgical outcome following curative resection of mid/distal bile duct cancer. | ||||||||||
| Author: | Park, Joon Seong|Park, Young Nyun|Lee, Kang Young|Kim, Jae Keun|Yoon, Dong Sup | ||||||||||
| PMID: | 23478949 | ||||||||||
| 37. | |||||||||||
| Journal: | Surg Today. 2014 Oct;44(10):1975-81. | ||||||||||
| Title: | Early detection of metachronous bile duct cancer in Lynch syndrome: report of a case. | ||||||||||
| Author: | Shigeyasu, Kunitoshi|Tanakaya, Kohji|Nagasaka, Takeshi|Aoki, Hideki|Fujiwara, Toshiyoshi|Sugano, Kokichi|Ishikawa, Hideki|Yoshida, Teruhiko|Moriya, Yoshihiro|Furukawa, Yoichi|Goel, Ajay|Takeuchi, Hitoshi | ||||||||||
| PMID: | 23896635 | ||||||||||
| 38. | |||||||||||
| Journal: | Mod Pathol. 2014 May;27(5):731-9. | ||||||||||
| Title: | High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases. | ||||||||||
| Author: | Jang, Sejin|Chun, Sung-Min|Hong, Seoung-Mo|Sung, Chang Ohk|Park, Hosub|Kang, Hyo Jeong|Kim, Kyu-pyo|Lee, Young Joo|Yu, Eunsil | ||||||||||
| PMID: | 24186137 | ||||||||||
| 39. | |||||||||||
| Journal: | Virchows Arch. 2015 Apr;466(4):393-402. | ||||||||||
| Title: | Microsatellite instability in gallbladder carcinoma. | ||||||||||
| Author: | Moy, Andrea P|Shahid, Mohammad|Ferrone, Cristina R|Borger, Darrell R|Zhu, Andrew X|Ting, David|Deshpande, Vikram | ||||||||||
| PMID: | 25680569 | ||||||||||
| 40. | |||||||||||
| Journal: | Int J Mol Sci. 2017 May 23;18(6). pii: ijms18061111. | ||||||||||
| Title: | Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma. | ||||||||||
| Author: | Nakaoka, Toshiaki|Saito, Yoshimasa|Saito, Hidetsugu | ||||||||||
| PMID: | 28545228 | ||||||||||
| 41. | |||||||||||
| Journal: | J Gastrointest Cancer. 2018 Mar;49(1):93-96. | ||||||||||
| Title: | Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome. | ||||||||||
| Author: | Cloyd, Jordan M|Chun, Yun Shin|Ikoma, Naruhiko|Vauthey, Jean Nicolas|Aloia, Tlhomas A|Cuddy, Amanda|Rodriguez-Bigas, Miguel A|Nancy You, Y | ||||||||||
| PMID: | 29238914 | ||||||||||
| 42. | |||||||||||
| Journal: | J Hepatol. 2018 May;68(5):959-969. | ||||||||||
| Title: | Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. | ||||||||||
| Author: | Wardell, Christopher P|Fujita, Masashi|Yamada, Toru|Simbolo, Michele|Fassan, Matteo|Karlic, Rosa|Polak, Paz|Kim, Jaegil|Hatanaka, Yutaka|Maejima, Kazuhiro|Lawlor, Rita T|Nakanishi, Yoshitsugu|Mitsuhashi, Tomoko|Fujimoto, Akihiro|Furuta, Mayuko|Ruzzenente, | ||||||||||
| PMID: | 29360550 | ||||||||||
| 43. | |||||||||||
| Journal: | Int J Mol Sci. 2018 May 9;19(5). pii: ijms19051421. | ||||||||||
| Title: | Microsatellite Instability Occurs Rarely in Patients with Cholangiocarcinoma: A Retrospective Study from a German Tertiary Care Hospital. | ||||||||||
| Author: | Winkelmann, Ria|Schneider, Markus|Hartmann, Sylvia|Schnitzbauer, Andreas A|Zeuzem, Stefan|Peveling-Oberhag, Jan|Hansmann, Martin Leo|Walter, Dirk | ||||||||||
| PMID: | 29747443 | ||||||||||
| 44. | |||||||||||
| Journal: | Oncol Lett. 2018 Sep;16(3):2989-2994. | ||||||||||
| Title: | Clinical significance of chromodomain helicase/ATPase DNA binding protein 1-like and human mutL homolog 1 gene expression in cholangiocarcinoma. | ||||||||||
| Author: | Hua, Jingwen|Li, Shiniao|Huang, Changwen | ||||||||||
| PMID: | 30127888 | ||||||||||