Primary Site >> Biliary tract Cancer

Gene >> MLH1

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Ref: Analysis of microsatellite instability, TGF-beta type II receptor gene mutations and hMSH2 and hMLH1 allele losses in pancreaticobiliary maljunction-associated biliary tract tumors.
PMID: 10470113
 Ref: Allelic loss in human intrahepatic cholangiocarcinoma: correlation between chromosome 8p22 and tumor progression.
PMID: 11004673
Ref: Surveillance on mutation carriers of DNA mismatch repair genes.
PMID: 11079789
 Ref: Infrequent microsatellite instability in biliary tract cancer.
PMID: 11223838
 Ref: Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain.
PMID: 11920650
Ref: Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma.
PMID: 11986189
Ref: Establishment and characterisation of six human biliary tract cancer cell lines.
PMID: 12107841
Ref: Microsatellite alterations in liver fluke related cholangiocarcinoma are associated with poor prognosis.
PMID: 12175538
Ref: Microsatellite instability in thorotrast-induced human intrahepatic cholangiocarcinoma.
PMID: 12402306
Ref: Microsatellite instability in intraductal papillary neoplasms of the biliary tract.
PMID: 12481012
 Ref: Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.
PMID: 12730870
Ref: Expression of Fhit, Mlh1, and P53 protein in human gallbladder carcinoma.
PMID: 12969785
Ref: Microsatellite instability in chronic cholecystitis is indicative of an early stage in gallbladder carcinogenesis.
PMID: 14502806
Ref: Infrequent microsatellite instability in liver fluke infection-associated intrahepatic cholangiocarcinomas from Thailand.
PMID: 14506736
Ref: Lack of microsatellite instability in neoplasms of ampulla of Vater.
PMID: 14516316
Ref: Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer.
PMID: 14527906
 Ref: Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.
PMID: 15471559
 Ref: Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma.
PMID: 15467712
Ref: Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma.
PMID: 15617839
Ref: Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder.
PMID: 15692793
Ref: Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest.
PMID: 15870882
Ref: Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers.
PMID: 15915369
Ref: The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells.
PMID: 16309194
 Ref: Promoter methylation profile in gallbladder cancer.
PMID: 16699861
Ref: Immunohistochemical expression of mismatch repair genes: a screening tool for predicting mutator phenotype in liver fluke infection-associated intrahepatic cholangiocarcinoma.
PMID: 16773692
 Ref: Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma.
PMID: 17084965
Ref: CPT-11 (SN-38) chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expression.
PMID: 17465213
Ref: Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability.
PMID: 17653761
Ref: Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time?
PMID: 17962726
 Ref: [Gene methylation patterns in digestive tumors].
PMID: 18769787
 Ref: Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.
PMID: 19252434
 Ref: DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases.
PMID: 20395525
 Ref: Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas.
PMID: 21307665
 Ref: Irrelevance of microsatellite instability in the epidemiology of sporadic pancreatic ductal adenocarcinoma.
PMID: 23029359
Ref: Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas.
PMID: 23106580
 Ref: P16 hypermethylation predicts surgical outcome following curative resection of mid/distal bile duct cancer.
PMID: 23478949
 Ref: Early detection of metachronous bile duct cancer in Lynch syndrome: report of a case.
PMID: 23896635
Ref: High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases.
PMID: 24186137
 Ref: Microsatellite instability in gallbladder carcinoma.
PMID: 25680569
 Ref: Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma.
PMID: 28545228
 Ref: Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome.
PMID: 29238914
Ref: Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
PMID: 29360550
Ref: Microsatellite Instability Occurs Rarely in Patients with Cholangiocarcinoma: A Retrospective Study from a German Tertiary Care Hospital.
PMID: 29747443
Ref: Clinical significance of chromodomain helicase/ATPase DNA binding protein 1-like and human mutL homolog 1 gene expression in cholangiocarcinoma.
PMID: 30127888