Literatures

Primary Site >> Colorectal Cancer

Gene >> MCL1

1.
Journal:	Cancer Res. 1996 May 15;56(10):2422-7.
Title:	Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.
Author:	Krajewska, M\|Moss, S F\|Krajewski, S\|Song, K\|Holt, P R\|Reed, J C
PMID:	8625322

2.
Journal:	Oncol Res. 1996;8(7-8):317-23.
Title:	Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines.
Author:	Goldwasser, F\|Bae, I\|Fornace, A J Jr\|Pommier, Y
PMID:	8938795

3.
Journal:	Ann Oncol. 2001 Feb;12(2):209-16.
Title:	5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.
Author:	Backus, H H\|Dukers, D F\|van Groeningen, C J\|Vos, W\|Bloemena, E\|Wouters, D\|van Riel, J M\|Smid, K\|Giaccone, G\|Pinedo, H M\|Peters, G J
PMID:	11300326

4.
Journal:	Ann Oncol. 2001 Jun;12(6):779-85.
Title:	Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer.
Author:	Backus, H H\|van Riel, J M\|van Groeningen, C J\|Vos, W\|Dukers, D F\|Bloemena, E\|Wouters, D\|Pinedo, H M\|Peters, G J
PMID:	11484952

5.
Journal:	Clin Cancer Res. 2001 Nov;7(11):3590-7.
Title:	E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells.
Author:	Elliott, M J\|Dong, Y B\|Yang, H\|McMasters, K M
PMID:	11705881

6.
Journal:	J Clin Pathol. 2002 Mar;55(3):206-11.
Title:	Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases.
Author:	Backus, H H J\|Van Groeningen, C J\|Vos, W\|Dukers, D F\|Bloemena, E\|Wouters, D\|Pinedo, H M\|Peters, G J
PMID:	11896073

7.
Journal:	Biochem Pharmacol. 2003 Jul 1;66(1):93-103.
Title:	Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Author:	Zhang, Manchao\|Liu, Hongpeng\|Guo, Ribo\|Ling, Yan\|Wu, Xiaojin\|Li, Bihua\|Roller, Peter P\|Wang, Shaomeng\|Yang, Dajun
PMID:	12818369

8.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G919-28. Epub 2003 Jul
Title:	5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis.
Author:	Farah, Myriam\|Parhar, Kuljit\|Moussavi, Maryam\|Eivemark, Sharlene\|Salh, Baljinder
PMID:	12842827

9.
Journal:	Toxicol Appl Pharmacol. 2004 Jun 1;197(2):84-95.
Title:	Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production.
Author:	Shen, Shing-Chuan\|Ko, Ching Huai\|Tseng, Shi-Wen\|Tsai, Shu-Huei\|Chen, Yen-Chou
PMID:	15163544

10.
Journal:	FEBS Lett. 2004 Nov 5;577(1-2):309-13.
Title:	Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis.
Author:	Vaculova, Alena\|Hofmanova, Jirina\|Soucek, Karel\|Andera, Ladislav\|Kozubik, Alois
PMID:	15527805

11.
Journal:	Wien Klin Wochenschr. 2005 Feb;117(4):136-40.
Title:	Changes in Mcl-1 expression in rectal cancer in relation to neo-adjuvant radiotherapy.
Author:	Ulrich-Pur, Herbert\|Erovic, Boban M\|Soleiman, Afschin\|Jech, Barbara\|Pennwieser, Wolfgang\|Czembirek, Cornelia\|Zielinski, Christoph C\|Thurnher, Dietmar
PMID:	15847193

12.
Journal:	Gastroenterology. 2005 Aug;129(2):577-90.
Title:	Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2.
Author:	Komatsu, Koga\|Buchanan, F Gregory\|Katkuri, Sharada\|Morrow, Jason D\|Inoue, Hiroyasu\|Otaka, Michiro\|Watanabe, Sumio\|DuBois, Raymond N
PMID:	16083714

13.
Journal:	Am J Pathol. 2005 Oct;167(4):969-80.
Title:	Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.
Author:	Lin, Quan\|Lai, Raymond\|Chirieac, Lucian R\|Li, Changping\|Thomazy, Vilmos A\|Grammatikakis, Ioannis\|Rassidakis, George Z\|Zhang, Wei\|Fujio, Yasushi\|Kunisada, Keita\|Hamilton, Stanley R\|Amin, Hesham M
PMID:	16192633

14.
Journal:	Naunyn Schmiedebergs Arch Pharmacol. 2006 Dec;374(3):223-33.
Title:	Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
Author:	Lu, Pin-Hsuan\|Kung, Fan-Lu\|Kuo, Sheng-Chu\|Chueh, Shih-Chieh\|Guh, Jih-Hwa
PMID:	17102938

15.
Journal:	FEBS Lett. 2006 Dec 11;580(28-29):6565-9.
Title:	Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
Author:	Vaculova, Alena\|Hofmanova, Jirina\|Soucek, Karel\|Kozubik, Alois
PMID:	17113582

16.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G66-75.
Title:	Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.
Author:	Lim, Do Y\|Jeong, Yoonhwa\|Tyner, Angela L\|Park, Jung H Y
PMID:	16901994

17.
Journal:	J Clin Pathol. 2007 Feb;60(2):173-9.
Title:	STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation.
Author:	Lassmann, Silke\|Schuster, Ingrid\|Walch, Axel\|Gobel, Heike\|Jutting, Uta\|Makowiec, Frank\|Hopt, Ulrich\|Werner, Martin
PMID:	17264243

18.
Journal:	Mol Pharmacol. 2007 Sep;72(3):704-14. Epub 2007 Jun 19.
Title:	Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
Author:	Mitchell, Clint\|Kabolizadeh, Peyman\|Ryan, John\|Roberts, John D\|Yacoub, Adly\|Curiel, David T\|Fisher, Paul B\|Hagan, Michael P\|Farrell, Nicholas P\|Grant, Steven\|Dent, Paul
PMID:	17578896

19.
Journal:	Cancer Cell. 2007 Jul;12(1):4-6.
Title:	Clearing the TRAIL for Cancer Therapy.
Author:	Hall, Mark A\|Cleveland, John L
PMID:	17613431

20.
Journal:	Cancer Res. 2007 Sep 1;67(17):8325-34.
Title:	Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Author:	Bettayeb, Karima\|Tirado, Oscar M\|Marionneau-Lambot, Severine\|Ferandin, Yoan\|Lozach, Olivier\|Morris, Jonathan C\|Mateo-Lozano, Silvia\|Drueckes, Peter\|Schachtele, Christoph\|Kubbutat, Michael H G\|Liger, Francois\|Marquet, Bernard\|Joseph, Benoit\|Echalier, Aude\|
PMID:	17804748

21.
Journal:	Int J Cancer. 2008 Mar 15;122(6):1426-9.
Title:	Differential sensitivity of human colon cancer cell lines to the nucleoside analogs ARC and DRB.
Author:	Bhat, Uppoor G\|Gartel, Andrei L
PMID:	17999411

22.
Journal:	Biochem Pharmacol. 2008 Feb 15;75(4):847-56.
Title:	WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.
Author:	Hsiao, Che-Jen\|Li, Tsia-Kun\|Chan, Ya-Ling\|Hsin, Ling-Wei\|Liao, Cho-Hwa\|Lee, Chien-Hua\|Lyu, Ping-Chiang\|Guh, Jih-Hwa
PMID:	18035333

23.
Journal:	Mol Endocrinol. 2008 Apr;22(4):868-80. Epub 2007 Dec 20.
Title:	The antiapoptotic role of pregnane X receptor in human colon cancer cells.
Author:	Zhou, Jie\|Liu, Mingjie\|Zhai, Yonggong\|Xie, Wen
PMID:	18096695

24.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G1025-32.
Title:	Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2.
Author:	Subramaniam, Dharmalingam\|Natarajan, Gopalan\|Ramalingam, Satish\|Ramachandran, Ilangovan\|May, Randal\|Queimado, Lurdes\|Houchen, Courtney W\|Anant, Shrikant
PMID:	18292181

25.
Journal:	Apoptosis. 2008 Aug;13(8):972-82.
Title:	Inhibition of proteasomal degradation of Mcl-1 by cobalt chloride suppresses cobalt chloride-induced apoptosis in HCT116 colorectal cancer cells.
Author:	Lee, Melanie\|Lapham, Abigail\|Brimmell, Matthew\|Wilkinson, Helen\|Packham, Graham
PMID:	18543107

26.
Journal:	Oncogene. 2008 Oct 9;27(46):6012-22.
Title:	A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma.
Author:	Ndozangue-Touriguine, O\|Sebbagh, M\|Merino, D\|Micheau, O\|Bertoglio, J\|Breard, J
PMID:	18560353

27.
Journal:	World J Gastroenterol. 2008 Jun 28;14(24):3829-40.
Title:	Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells.
Author:	Schulze-Bergkamen, Henning\|Ehrenberg, Roland\|Hickmann, Lothar\|Vick, Binje\|Urbanik, Toni\|Schimanski, Christoph-C\|Berger, Martin-R\|Schad, Arno\|Weber, Achim\|Heeger, Steffen\|Galle, Peter-R\|Moehler, Markus
PMID:	18609706

28.
Journal:	Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):599-608.
Title:	Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Author:	Hsiao, Che-Jen\|Ho, Yunn-Fang\|Hsu, John T-A\|Chang, Wei-Ling\|Chen, Yi-Cheng\|Shen, Ya-Ching\|Lyu, Ping-Chiang\|Guh, Jih-Hwa
PMID:	18663430

29.
Journal:	J Exp Med. 2008 Sep 1;205(9):2163-75.
Title:	A critical role for Apc in hematopoietic stem and progenitor cell survival.
Author:	Qian, Zhijian\|Chen, Lina\|Fernald, Anthony A\|Williams, Bart O\|Le Beau, Michelle M
PMID:	18725524

30.
Journal:	J Photochem Photobiol B. 2008 Nov 13;93(2):108-18.
Title:	Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin.
Author:	Kleban, Jan\|Mikes, Jaromir\|Horvath, Viktor\|Sackova, Veronika\|Hofmanova, Jirina\|Kozubik, Alois\|Fedorocko, Peter
PMID:	18771933

31.
Journal:	Clin Cancer Res. 2008 Dec 15;14(24):8132-42.
Title:	Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.
Author:	Okumura, Kenji\|Huang, Shengbing\|Sinicrope, Frank A
PMID:	19088028

32.
Journal:	Mol Nutr Food Res. 2009 May;53 Suppl 1:S102-13.
Title:	Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs.
Author:	Hofmanova, Jirina\|Vaculova, Alena\|Koubkova, Zuzana\|Hyzd'alova, Martina\|Kozubik, Alois
PMID:	19156717

33.
Journal:	J Biol Chem. 2009 Apr 3;284(14):9176-83.
Title:	HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins.
Author:	Jacobs, Aaron T\|Marnett, Lawrence J
PMID:	19179333

34.
Journal:	J Cell Biol. 2009 Apr 20;185(2):279-90.
Title:	Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members.
Author:	Gallenne, Tristan\|Gautier, Fabien\|Oliver, Lisa\|Hervouet, Eric\|Noel, Belinda\|Hickman, John A\|Geneste, Olivier\|Cartron, Pierre-Francois\|Vallette, Francois M\|Manon, Stephen\|Juin, Philippe
PMID:	19380879

35.
Journal:	Photochem Photobiol Sci. 2009 Nov;8(11):1558-67.
Title:	The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells.
Author:	Mikes, Jaromir\|Koval', Jan\|Jendzelovsky, Rastislav\|Sackova, Veronika\|Uhrinova, Ivana\|Kello, Martin\|Kulikova, Lucia\|Fedorocko, Peter
PMID:	19862414

36.
Journal:	PLoS One. 2010 Jan 18;5(1):e8755.
Title:	Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells.
Author:	Priault, Muriel\|Hue, Erika\|Marhuenda, Fanny\|Pilet, Paul\|Oliver, Lisa\|Vallette, Francois M
PMID:	20090905

37.
Journal:	Cancer Lett. 2010 Jul 28;293(2):158-66.
Title:	Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo.
Author:	Ding, Wanjing\|Cai, Tianyu\|Zhu, Hong\|Wu, Rui\|Tu, Chongxing\|Yang, Liuqing\|Lu, Wei\|He, Qiaojun\|Yang, Bo
PMID:	20137855

38.
Journal:	Anticancer Res. 2010 Jan;30(1):157-66.
Title:	PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis.
Author:	Dionne, Serge\|Levy, Emile\|Levesque, Denise\|Seidman, Ernest G
PMID:	20150631

39.
Journal:	Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S244-52.
Title:	Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells.
Author:	Qiu, Peiju\|Dong, Ping\|Guan, Huashi\|Li, Shiming\|Ho, Chi-Tang\|Pan, Min-Hsiung\|McClements, David Julian\|Xiao, Hang
PMID:	20397199

40.
Journal:	J Biol Chem. 2010 Jun 18;285(25):19162-72.
Title:	Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin.
Author:	Jani, Tanvi S\|DeVecchio, Jennifer\|Mazumdar, Tapati\|Agyeman, Akwasi\|Houghton, Janet A
PMID:	20424169

41.
Journal:	J Nat Prod. 2010 May 28;73(5):998-1001.
Title:	Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria.
Author:	Oh, Hyuncheol\|Jensen, Paul R\|Murphy, Brian T\|Fiorilla, Catherine\|Sullivan, John F\|Ramsey, Timothy\|Fenical, William
PMID:	20462271

42.
Journal:	Cancer Biol Ther. 2010 Aug 15;10(4):354-61. Epub 2010 Aug 18.
Title:	Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells.
Author:	Yun, Hyun Jin\|Kim, Sun Young\|Kwon, Young Yon\|Kim, Chun-Ho\|Kang, Chang-Mo\|Kim, Eun Ju
PMID:	20534983

43.
Journal:	BMC Gastroenterol. 2010 Aug 22;10:96.
Title:	Fucoidan present in brown algae induces apoptosis of human colon cancer cells.
Author:	Kim, Eun Ji\|Park, So Young\|Lee, Jae-Yong\|Park, Jung Han Yoon
PMID:	20727207

44.
Journal:	PLoS One. 2010 Sep 22;5(9):e12895.
Title:	CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis.
Author:	Drury, Luke J\|Wendt, Michael K\|Dwinell, Michael B
PMID:	20877573

45.
Journal:	Int J Clin Exp Pathol. 2010 Oct 12;3(8):768-74.
Title:	Correlation between Mcl-1 and pAKT protein expression in colorectal cancer.
Author:	Henderson-Jackson, Evita B\|Helm, James\|Ghayouri, Masoumeh\|Hakam, Ardeshir\|Nasir, Aejaz\|Leon, Marino\|Bui, Marilyn\|Yeatman, Timothy\|Coppola, Domenico
PMID:	21151390

46.
Journal:	Cancer Sci. 2011 Apr;102(4):742-8.
Title:	Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1.
Author:	Choi, Eun-Sun\|Shim, Jung-Hyun\|Jung, Ji-Youn\|Kim, Hyeong-Jin\|Choi, Kyeong-Hee\|Shin, Ji-Ae\|Nam, Jeong-Seok\|Cho, Nam-Pyo\|Cho, Sung-Dae
PMID:	21241418

47.
Journal:	Nature. 2011 Mar 3;471(7336):104-9.
Title:	SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Author:	Inuzuka, Hiroyuki\|Shaik, Shavali\|Onoyama, Ichiro\|Gao, Daming\|Tseng, Alan\|Maser, Richard S\|Zhai, Bo\|Wan, Lixin\|Gutierrez, Alejandro\|Lau, Alan W\|Xiao, Yonghong\|Christie, Amanda L\|Aster, Jon\|Settleman, Jeffrey\|Gygi, Steven P\|Kung, Andrew L\|Look, Thomas\|Nakay
PMID:	21368833

48.
Journal:	J Clin Invest. 2011 Mar;121(3):1075-87.
Title:	Hypoxic human cancer cells are sensitized to BH-3 mimetic-induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.
Author:	Harrison, Luke R E\|Micha, Dimitra\|Brandenburg, Martin\|Simpson, Kathryn L\|Morrow, Christopher J\|Denneny, Olive\|Hodgkinson, Cassandra\|Yunus, Zaira\|Dempsey, Clare\|Roberts, Darren\|Blackhall, Fiona\|Makin, Guy\|Dive, Caroline
PMID:	21393866

49.
Journal:	Mol Cancer. 2011 Apr 25;10:46.
Title:	High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde.
Author:	Kim, Hak-Bong\|Kim, Mi-Ju\|Kim, Dae-Young\|Lee, Jae-Won\|Bae, Jae-Ho\|Kim, Dong-Wan\|Kang, Chi-Dug\|Kim, Sun-Hee
PMID:	21513580

50.
Journal:	Oncol Rep. 2011 Jul;26(1):109-14.
Title:	Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells.
Author:	Lamy, Virginie\|Bousserouel, Souad\|Gosse, Francine\|Minker, Carole\|Lobstein, Annelise\|Raul, Francis
PMID:	21519792

51.
Journal:	Clin Colorectal Cancer. 2011 Sep;10(3):188-93.
Title:	Expression of the antiapoptotic protein survivin in colon cancer.
Author:	Hernandez, Jonathan M\|Farma, Jeffrey M\|Coppola, Domenico\|Hakam, Ardeshir\|Fulp, William J\|Chen, Dung-Tsa\|Siegel, Erin M\|Yeatman, Timothy J\|Shibata, David
PMID:	21855041

52.
Journal:	Mol Cancer Ther. 2011 Dec;10(12):2373-83.
Title:	The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells.
Author:	Klymenko, Tetyana\|Brandenburg, Martin\|Morrow, Christopher\|Dive, Caroline\|Makin, Guy
PMID:	22006676

53.
Journal:	BMC Cancer. 2011 Nov 14;11:485.
Title:	Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors.
Author:	Zhou, Wei\|Hu, Jingzi\|Tang, Haimei\|Wang, Da\|Huang, Xuefeng\|He, Chao\|Zhu, Hongbo
PMID:	22078414

54.
Journal:	ISRN Endocrinol. 2011;2011:575397.
Title:	Cellular signal transduction pathways by leptin in colorectal cancer tissue: preliminary results.
Author:	Nowakowska-Zajdel, Ewa\|Mazurek, Urszula\|Stachowicz, Malgorzata\|Niedworok, Elzbieta\|Fatyga, Edyta\|Muc-Wierzgon, Malgorzata
PMID:	22363883

55.
Journal:	Dig Dis Sci. 2012 Feb;57(2):371-80.
Title:	Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells.
Author:	Chung, Cho-Yun\|Park, Young-Lan\|Song, Young-A\|Myung, Eun\|Kim, Kyu-Yeol\|Lee, Gi-Hoon\|Ki, Ho-Seok\|Park, Kang-Jin\|Cho, Sung-Bum\|Lee, Wan-Sik\|Jung, Young-Do\|Kim, Kyung-Keun\|Joo, Young-Eun
PMID:	21901254

56.
Journal:	Oncogene. 2012 Jun 28;31(26):3177-89.
Title:	Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.
Author:	Wang, C\|Youle, R J
PMID:	22056880

57.
Journal:	J Cell Physiol. 2012 Aug;227(8):3128-37.
Title:	The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells.
Author:	Chien, Chih-Chiang\|Ko, Ching-Huai\|Shen, Shing-Chuan\|Yang, Liang-Yo\|Chen, Yen-Chou
PMID:	22170686

58.
Journal:	Apoptosis. 2012 Apr;17(4):388-99.
Title:	Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad.
Author:	Yin, Shutao\|Dong, Yinhui\|Li, Jinghua\|Fan, Lihong\|Wang, Lei\|Lu, Junxuan\|Vang, Ole\|Hu, Hongbo
PMID:	22179721

59.
Journal:	Carcinogenesis. 2012 Jun;33(6):1193-202.
Title:	N-alpha-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
Author:	Xu, Huiyu\|Jiang, Beihai\|Meng, Lin\|Ren, Tingting\|Zeng, Yan\|Wu, Jian\|Qu, Like\|Shou, Chengchao
PMID:	22496479

60.
Journal:	Apoptosis. 2012 Aug;17(8):797-809.
Title:	The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.
Author:	Kauntz, Henriette\|Bousserouel, Souad\|Gosse, Francine\|Raul, Francis
PMID:	22555452

61.
Journal:	Toxicol In Vitro. 2012 Sep;26(6):775-82.
Title:	Inhibition of GSK-3beta reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells.
Author:	Jendzelovsky, Rastislav\|Koval, Jan\|Mikes, Jaromir\|Papcova, Zuzana\|Plsikova, Jana\|Fedorocko, Peter
PMID:	22683934

62.
Journal:	Cell Cycle. 2012 Sep 1;11(17):3312-23.
Title:	Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation.
Author:	Cheng, Hairong\|Hong, Bo\|Zhou, Lanlan\|Allen, Joshua E\|Tai, Guihua\|Humphreys, Robin\|Dicker, David T\|Liu, Yingqiu Y\|El-Deiry, Wafik S
PMID:	22895172

63.
Journal:	J Biol Chem. 2012 Nov 9;287(46):39193-204.
Title:	Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins.
Author:	Sakurikar, Nandini\|Eichhorn, Joshua M\|Chambers, Timothy C
PMID:	22965228

64.
Journal:	Oncogene. 2013 Jun 20;32(25):3071-9.
Title:	MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R.
Author:	Gong, J\|Zhang, J-P\|Li, B\|Zeng, C\|You, K\|Chen, M-X\|Yuan, Y\|Zhuang, S-M
PMID:	22824797

65.
Journal:	J Pathol. 2013 Feb;229(3):410-21.
Title:	Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL.
Author:	Pennarun, Bodvael\|Kleibeuker, Jan H\|Boersma-van Ek, Wytske\|Kruyt, Frank A E\|Hollema, Harry\|de Vries, Elisabeth G E\|de Jong, Steven
PMID:	23132258

66.
Journal:	Cancer Invest. 2013 Jan;31(1):17-23.
Title:	MiR-125a/b regulates the activation of cancer stem cells in paclitaxel-resistant colon cancer.
Author:	Chen, Jixiang\|Chen, Yuxiang\|Chen, Zihua
PMID:	23327190

67.
Journal:	Cell Physiol Biochem. 2013;31(1):113-22.
Title:	External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-kB and induces cell cycle arrest and apoptosis in colorectal cancer cells.
Author:	Yan, Xin\|Shen, Hua\|Jiang, Hongjian\|Hu, Dan\|Wang, Jun\|Wu, Xinqi
PMID:	23363659

68.
Journal:	Apoptosis. 2013 Jun;18(6):739-50.
Title:	The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms.
Author:	Beranova, Lenka\|Pombinho, Antonio R\|Spegarova, Jarmila\|Koc, Michal\|Klanova, Magdalena\|Molinsky, Jan\|Klener, Pavel\|Bartunek, Petr\|Andera, Ladislav
PMID:	23456623

69.
Journal:	Mol Med Rep. 2013 May;7(5):1487-93.
Title:	Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-alpha, Caspase-8, Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro.
Author:	Chen, Yao-Li\|Yan, Meng-Yi\|Chien, Su-Yu\|Kuo, Shou-Jen\|Chen, Dar-Ren\|Cheng, Chun-Yuan\|Su, Chin-Cheng
PMID:	23525225

70.
Journal:	Mol Cancer. 2013 May 16;12(1):42.
Title:	The novel BH3 alpha-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.
Author:	Cao, Xiaobo\|Yap, Jeremy L\|Newell-Rogers, M Karen\|Peddaboina, Chander\|Jiang, Weihua\|Papaconstantinou, Harry T\|Jupitor, Dan\|Rai, Arun\|Jung, Kwan-Young\|Tubin, Richard P\|Yu, Wenbo\|Vanommeslaeghe, Kenno\|Wilder, Paul T\|MacKerell, Alexander D Jr\|Fletcher, Steven
PMID:	23680104

71.
Journal:	Int J Oncol. 2013 Sep;43(3):927-35.
Title:	Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells.
Author:	Greene, Lisa M\|Nolan, Derek P\|Regan-Komito, Daniel\|Campiani, Giuseppe\|Williams, D Clive\|Zisterer, Daniela M
PMID:	23799546

72.
Journal:	Apoptosis. 2013 Oct;18(10):1163-74.
Title:	Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells.
Author:	Timme, Cindy R\|Gruidl, Mike\|Yeatman, Timothy J
PMID:	23887890

73.
Journal:	J Biol Chem. 2013 Oct 4;288(40):28713-26.
Title:	The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters.
Author:	Kim, Joo Ae\|Kim, Youngmi\|Kwon, Byoung-Mog\|Han, Dong Cho
PMID:	23983126

74.
Journal:	Cell Death Dis. 2013 Sep 12;4:e801.
Title:	Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.
Author:	Maamer-Azzabi, A\|Ndozangue-Touriguine, O\|Breard, J
PMID:	24030153

75.
Journal:	PLoS One. 2013 Oct 3;8(10):e76446.
Title:	Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro.
Author:	Koehler, Bruno Christian\|Scherr, Anna-Lena\|Lorenz, Stephan\|Urbanik, Toni\|Kautz, Nicole\|Elssner, Christin\|Welte, Stefan\|Bermejo, Justo Lorenzo\|Jager, Dirk\|Schulze-Bergkamen, Henning
PMID:	24098503

76.
Journal:	Mol Cancer Ther. 2013 Dec;12(12):2640-50.
Title:	Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263.
Author:	Shao, Huanjie\|Jing, Kai\|Mahmoud, Esraa\|Huang, Haihong\|Fang, Xianjun\|Yu, Chunrong
PMID:	24126433

77.
Journal:	Pharmacol Rep. 2013;65(5):1366-74.
Title:	Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells.
Author:	Park, Ji-Hyuk\|Kwon, Hee-Young\|Sohn, Eun Jung\|Kim, Kyung A\|Kim, Bonglee\|Jeong, Soo-Jin\|Song, Jun Ho\|Koo, Jin Suk\|Kim, Sung-Hoon
PMID:	24399733

78.
Journal:	Cancer Discov. 2014 Jan;4(1):42-52.
Title:	mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
Author:	Faber, Anthony C\|Coffee, Erin M\|Costa, Carlotta\|Dastur, Anahita\|Ebi, Hiromichi\|Hata, Aaron N\|Yeo, Alan T\|Edelman, Elena J\|Song, Youngchul\|Tam, Ah Ting\|Boisvert, Jessica L\|Milano, Randy J\|Roper, Jatin\|Kodack, David P\|Jain, Rakesh K\|Corcoran, Ryan B\|Rivera,
PMID:	24163374

79.
Journal:	Mol Med Rep. 2014 Jan;9(1):243-8.
Title:	Caffeine inhibits paclitaxelinduced apoptosis in colorectal cancer cells through the upregulation of Mcl1 levels.
Author:	Mhaidat, Nizar M\|Alzoubi, Karem H\|Al-Azzam, Sayer I\|Alsaad, Alhareth A
PMID:	24173825

80.
Journal:	J Cell Sci. 2014 Feb 15;127(Pt 4):788-800.
Title:	Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation.
Author:	Cope, Claire L\|Gilley, Rebecca\|Balmanno, Kathryn\|Sale, Matthew J\|Howarth, Karen D\|Hampson, Mark\|Smith, Paul D\|Guichard, Sylvie M\|Cook, Simon J
PMID:	24363449

81.
Journal:	Exp Cell Res. 2014 Apr 1;322(2):415-24.
Title:	Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival.
Author:	Eichhorn, Joshua M\|Alford, Sarah E\|Sakurikar, Nandini\|Chambers, Timothy C
PMID:	24556425

82.
Journal:	Cancer Lett. 2014 Jun 1;347(2):204-11.
Title:	Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Author:	Roper, Jatin\|Sinnamon, Mark J\|Coffee, Erin M\|Belmont, Peter\|Keung, Lily\|Georgeon-Richard, Larissa\|Wang, Wei Vivian\|Faber, Anthony C\|Yun, Jihye\|Yilmaz, Omer H\|Bronson, Roderick T\|Martin, Eric S\|Tsichlis, Philip N\|Hung, Kenneth E
PMID:	24576621

83.
Journal:	Neoplasia. 2014 Feb;16(2):147-57.
Title:	BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.
Author:	Potter, Danielle S\|Kelly, Paul\|Denneny, Olive\|Juvin, Veronique\|Stephens, Len R\|Dive, Caroline\|Morrow, Christopher J
PMID:	24709422

84.
Journal:	PLoS One. 2014 Apr 17;9(4):e95588.
Title:	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability.
Author:	Seo, Bo Ram\|Min, Kyoung-Jin\|Cho, Il Je\|Kim, Sang Chan\|Kwon, Taeg Kyu
PMID:	24743574

85.
Journal:	Chem Biol Interact. 2014 Jul 25;218:42-9.
Title:	Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.
Author:	Lin, Mei-Hsiang\|Cheng, Chia-Hsiung\|Chen, Ku-Chung\|Lee, Wai-Theng\|Wang, Yen-Fang\|Xiao, Cai-Qin\|Lin, Cheng-Wei
PMID:	24812029

86.
Journal:	PLoS One. 2014 Sep 5;9(9):e106571.
Title:	Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells.
Author:	Koehler, Bruno Christian\|Scherr, Anna-Lena\|Lorenz, Stephan\|Elssner, Christin\|Kautz, Nicole\|Welte, Stefan\|Jaeger, Dirk\|Urbanik, Toni\|Schulze-Bergkamen, Henning
PMID:	25192188

87.
Journal:	J Hematol Oncol. 2014 Sep 9;7:56.
Title:	Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.
Author:	Edwards, Shanique K E\|Baron, Jacqueline\|Moore, Carissa R\|Liu, Yan\|Perlman, David H\|Hart, Ronald P\|Xie, Ping
PMID:	25200342

88.
Journal:	Clin Cancer Res. 2014 Nov 1;20(21):5446-55.
Title:	Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimetics.
Author:	Mattoo, Abid R\|Zhang, Jingyu\|Espinoza, Luis A\|Jessup, J Milburn
PMID:	25208882

89.
Journal:	Biochem Pharmacol. 2014 Dec 1;92(3):415-24.
Title:	Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway.
Author:	Jelinkova, Iva\|Safarikova, Barbora\|Vondalova Blanarova, Olga\|Skender, Belma\|Hofmanova, Jirina\|Sova, Petr\|Moyer, Mary Pat\|Kozubik, Alois\|Kolar, Zdenek\|Ehrmann, Jiri\|Hyrslova Vaculova, Alena
PMID:	25285768

90.
Journal:	Cancer Lett. 2014 Dec 28;355(2):253-63.
Title:	Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak.
Author:	Sun, Jian-guo\|Xiang, Jun\|Zeng, Xue-li\|Li, Xia\|Wu, Ping\|Fung, Kwok Pui\|Liu, Fei-yan
PMID:	25304383

91.
Journal:	World J Gastroenterol. 2014 Nov 7;20(41):15275-88.
Title:	Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination.
Author:	Elkady, Ayman I\|Hussein, Rania Abd El Hamid\|Abu-Zinadah, Osama A
PMID:	25386076

92.
Journal:	Cell Death Differ. 2015 Jan;22(1):6-11.
Title:	Role of miR-15/16 in CLL.
Author:	Pekarsky, Y\|Croce, C M
PMID:	24971479

93.
Journal:	Apoptosis. 2015 Jan;20(1):63-74.
Title:	Dichloroacetate affects proliferation but not survival of human colorectal cancer cells.
Author:	Delaney, L M\|Ho, N\|Morrison, J\|Farias, N R\|Mosser, D D\|Coomber, B L
PMID:	25344893

94.
Journal:	J Mol Med (Berl). 2015 Mar;93(3):315-26.
Title:	BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.
Author:	Flanagan, L\|Lindner, A U\|de Chaumont, C\|Kehoe, J\|Fay, J\|Bacon, O\|Toomey, S\|Huber, H J\|Hennessy, B T\|Kay, E W\|McNamara, D A\|Prehn, J H M
PMID:	25388617

95.
Journal:	Cell Signal. 2015 Feb;27(2):293-305.
Title:	HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.
Author:	Lee, Dae-Hee\|Sung, Ki Sa\|Bartlett, David L\|Kwon, Yong Tae\|Lee, Yong J
PMID:	25446253

96.
Journal:	Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1410-8.
Title:	MicroRNA-29b is a Novel Prognostic Marker in Colorectal Cancer.
Author:	Inoue, Akira\|Yamamoto, Hirofumi\|Uemura, Mamoru\|Nishimura, Junichi\|Hata, Taishi\|Takemasa, Ichiro\|Ikenaga, Masakazu\|Ikeda, Masataka\|Murata, Kohei\|Mizushima, Tsunekazu\|Doki, Yuichiro\|Mori, Masaki
PMID:	25472644

97.
Journal:	Mol Cancer Res. 2015 Apr;13(4):659-69.
Title:	Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells.
Author:	Okamoto, Koichi\|Zaanan, Aziz\|Kawakami, Hisato\|Huang, Shengbing\|Sinicrope, Frank A
PMID:	25548100

98.
Journal:	Oncotarget. 2015 Jan 1;6(1):409-26.
Title:	Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1.
Author:	Jonchere, Barbara\|Vetillard, Alexandra\|Toutain, Bertrand\|Lam, David\|Bernard, Anne Charlotte\|Henry, Cecile\|De Carne Trecesson, Sophie\|Gamelin, Erick\|Juin, Philippe\|Guette, Catherine\|Coqueret, Olivier
PMID:	25565667

99.
Journal:	Am J Cancer Res. 2014 Dec 15;5(1):101-13. eCollection 2015.
Title:	Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer.
Author:	Lee, Wan-Sik\|Park, Young-Lan\|Kim, Nuri\|Oh, Hyung-Hoon\|Son, Dong-Jun\|Kim, Mi-Young\|Oak, Chan-Young\|Chung, Cho-Yun\|Park, Hyung-Chul\|Kim, Jong-Sun\|Myung, Dae-Seong\|Cho, Sung-Bum\|Kim, Hyun-Soo\|Joo, Young-Eun
PMID:	25628923

100.
Journal:	Oncotarget. 2015 May 10;6(13):11614-26.
Title:	FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells.
Author:	Woo, Seon Min\|Seo, Bo Ram\|Min, Kyoung-jin\|Kwon, Taeg Kyu
PMID:	25843953

101.
Journal:	Mol Cancer. 2015 Jul 2;14:126.
Title:	Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer.
Author:	Zhang, Haichao\|Xue, John\|Hessler, Paul\|Tahir, Stephen K\|Chen, Jun\|Jin, Sha\|Souers, Andrew J\|Leverson, Joel D\|Lam, Lloyd T
PMID:	26134786

102.
Journal:	Biomed Pharmacother. 2015 Oct;75:129-36.
Title:	miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1.
Author:	Tong, Zhiguo\|Liu, Nan\|Lin, Luoqiang\|Guo, Xinggang\|Yang, Dongdong\|Zhang, Qifan
PMID:	26297542

103.
Journal:	Mol Med Rep. 2015 Nov;12(5):6976-84.
Title:	ApoG2 inhibits the antiapoptotic protein, Mcl1, and induces mitochondriadependent apoptosis in human colorectal cancer cells.
Author:	Li, Tianxiao\|Yuan, Gang\|Zhang, Lin\|Ye, Lijun\|Li, Shuxia\|Fan, Yuhua\|Sun, Jian
PMID:	26352605

104.
Journal:	Nat Commun. 2015 Sep 22;6:8305.
Title:	Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.
Author:	Misale, Sandra\|Bozic, Ivana\|Tong, Jingshan\|Peraza-Penton, Ashley\|Lallo, Alice\|Baldi, Federica\|Lin, Kevin H\|Truini, Mauro\|Trusolino, Livio\|Bertotti, Andrea\|Di Nicolantonio, Federica\|Nowak, Martin A\|Zhang, Lin\|Wood, Kris C\|Bardelli, Alberto
PMID:	26392303

105.
Journal:	Oncotarget. 2015 Dec 22;6(41):43342-62.
Title:	Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis.
Author:	Vetillard, Alexandra\|Jonchere, Barbara\|Moreau, Marie\|Toutain, Bertrand\|Henry, Cecile\|Fontanel, Simon\|Bernard, Anne-Charlotte\|Campone, Mario\|Guette, Catherine\|Coqueret, Olivier
PMID:	26485768

106.
Journal:	Cancer Biol Ther. 2015;16(12):1710-9.
Title:	Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy.
Author:	Marks, Eric I\|Tan, Carlyn\|Zhang, Jun\|Zhou, Lanlan\|Yang, Zhaohai\|Scicchitano, Angelique\|El-Deiry, Wafik S
PMID:	26561209

107.
Journal:	BMC Cancer. 2015 Nov 19;15:919.
Title:	Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling.
Author:	Koehler, Bruno Christian\|Jassowicz, Adam\|Scherr, Anna-Lena\|Lorenz, Stephan\|Radhakrishnan, Praveen\|Kautz, Nicole\|Elssner, Christin\|Weiss, Johanna\|Jaeger, Dirk\|Schneider, Martin\|Schulze-Bergkamen, Henning
PMID:	26585594

108.
Journal:	Acta Pharmacol Sin. 2015 Dec;36(12):1514-9.
Title:	Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway.
Author:	Su, Li-ya\|Shi, Ying-xu\|Yan, Mei-rong\|Xi, Yaguang\|Su, Xiu-lan
PMID:	26592508

109.
Journal:	Int J Oncol. 2016 Feb;48(2):690-702.
Title:	Identifying molecular subtypes in human colon cancer using gene expression and DNA methylation microarray data.
Author:	Ren, Zhonglu\|Wang, Wenhui\|Li, Jinming
PMID:	26647925

110.
Journal:	J Cell Physiol. 2016 Oct;231(10):2196-204.
Title:	Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing.
Author:	Khan, Dilshad H\|Gonzalez, Carolina\|Tailor, Nikesh\|Hamedani, Mohammad K\|Leygue, Etienne\|Davie, James R
PMID:	26864447

111.
Journal:	Oncotarget. 2016 Mar 29;7(13):16349-61.
Title:	AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin.
Author:	Gao, Mei\|Kong, Qingbin\|Hua, Hui\|Yin, Yancun\|Wang, Jiao\|Luo, Ting\|Jiang, Yangfu
PMID:	26918349

112.
Journal:	Oncotarget. 2016 Apr 5;7(14):17970-85.
Title:	Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways.
Author:	Li, Gang\|Ying, Li\|Wang, Hong\|Wei, Si-Si\|Chen, Jie\|Chen, Yi-He\|Xu, Wei-Ping\|Jie, Qi-Qiang\|Zhou, Qing\|Li, Yi-Gang\|Wei, Yi-Dong\|Wang, Yue-Peng
PMID:	26918455

113.
Journal:	Cancer Res. 2016 Apr 15;76(8):2219-30.
Title:	Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.
Author:	Radhakrishnan, Praveenkumar\|Ruh, Nadine\|Harnoss, Jonathan M\|Kiss, Judit\|Mollenhauer, Martin\|Scherr, Anna-Lena\|Platzer, Lisa K\|Schmidt, Thomas\|Podar, Klaus\|Opferman, Joseph T\|Weitz, Juergen\|Schulze-Bergkamen, Henning\|Koehler, Bruno C\|Ulrich, Alexis\|Schneid
PMID:	26921340

114.
Journal:	Oncol Rep. 2016 Jun;35(6):3363-70.
Title:	Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways.
Author:	Liu, Jiming\|Li, Qiang\|Liu, Zhilong\|Lin, Liuming\|Zhang, Xiangqiang\|Cao, Mingrong\|Jiang, Jianwei
PMID:	27004568

115.
Journal:	Oncotarget. 2016 Jul 26;7(30):47699-47710.
Title:	BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells.
Author:	He, Kan\|Chen, Dongshi\|Ruan, Hang\|Li, Xiangyun\|Tong, Jingshan\|Xu, Xiang\|Zhang, Lin\|Yu, Jian
PMID:	27351224

116.
Journal:	Apoptosis. 2016 Oct;21(10):1144-57.
Title:	Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation.
Author:	Sun, Jian-Guo\|Ruan, Feng\|Zeng, Xue-Li\|Xiang, Jun\|Li, Xia\|Wu, Ping\|Fung, Kwok Pui\|Liu, Fei-Yan
PMID:	27421828

117.
Journal:	Am J Cancer Res. 2016 Jun 1;6(6):1345-57. eCollection 2016.
Title:	BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition.
Author:	Yang, Lifeng\|Wan, Juefeng\|Xiao, Sheng\|Barkhouse, Darryll\|Zhu, Ji\|Li, Guichao\|Lu, Bo\|Zhang, Zhen
PMID:	27429848

118.
Journal:	BMC Cancer. 2016 Jul 26;16:531.
Title:	Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells.
Author:	Risberg, Karianne\|Redalen, Kathrine Roe\|Sonstevold, Linda\|Bjornetro, Tonje\|Solvernes, Janne\|Ree, Anne Hansen
PMID:	27461218

119.
Journal:	Cell Death Dis. 2016 Aug 11;7(8):e2334.
Title:	Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation.
Author:	Chen, Lei\|Meng, Yue\|Sun, Qi\|Zhang, Zhongyu\|Guo, Xiaoqing\|Sheng, Xiaotong\|Tai, Guihua\|Cheng, Hairong\|Zhou, Yifa
PMID:	27512955

120.
Journal:	Oncotarget. 2016 Sep 13;7(37):59503-59518.
Title:	Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells.
Author:	Park, Seong Hye\|Lee, Dae-Hee\|Kim, Jung Lim\|Kim, Bo Ram\|Na, Yoo Jin\|Jo, Min Jee\|Jeong, Yoon A\|Lee, Suk-Young\|Lee, Sun Il\|Lee, Yong Yook\|Oh, Sang Cheul
PMID:	27517746

121.
Journal:	Alcohol Clin Exp Res. 2016 Oct;40(10):2094-2101.
Title:	Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1.
Author:	Koehler, Bruno Christian\|Arslic-Schmitt, Tatjana\|Peccerella, Theresa\|Scherr, Anna-Lena\|Schulze-Bergkamen, Henning\|Bruckner, Thomas\|Gdynia, Georg\|Jager, Dirk\|Mueller, Sebastian\|Bartsch, Helmut\|Seitz, Helmut K
PMID:	27581253

122.
Journal:	Mol Cancer Ther. 2016 Dec;15(12):3015-3027.
Title:	Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer.
Author:	Kawakami, Hisato\|Huang, Shengbing\|Pal, Krishnendu\|Dutta, Shamit K\|Mukhopadhyay, Debabrata\|Sinicrope, Frank A
PMID:	27765849

123.
Journal:	Mol Cell. 2016 Nov 17;64(4):803-814.
Title:	TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression.
Author:	Zhang, Xian\|Li, Chien-Feng\|Zhang, Ling\|Wu, Ching-Yuan\|Han, Lixia\|Jin, Guoxiang\|Rezaeian, Abdol Hossein\|Han, Fei\|Liu, Chunfang\|Xu, Chuan\|Xu, Xiaohong\|Huang, Chih-Yang\|Tsai, Fuu-Jen\|Tsai, Chang-Hai\|Watabe, Kounosuke\|Lin, Hui-Kuan
PMID:	27818144

124.
Journal:	Oncogene. 2017 Feb 9;36(6):787-796.
Title:	FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
Author:	Tong, J\|Tan, S\|Zou, F\|Yu, J\|Zhang, L
PMID:	27399335

125.
Journal:	Oncogene. 2017 Jun 1;36(22):3080-3093.
Title:	The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis.
Author:	Sarkar, M\|Khare, V\|Ghosh, M K
PMID:	27941883

126.
Journal:	EMBO Mol Med. 2017 Feb;9(2):181-197.
Title:	HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Author:	Myant, Kevin B\|Cammareri, Patrizia\|Hodder, Michael C\|Wills, Jimi\|Von Kriegsheim, Alex\|Gyorffy, Balazs\|Rashid, Mamun\|Polo, Simona\|Maspero, Elena\|Vaughan, Lynsey\|Gurung, Basanta\|Barry, Evan\|Malliri, Angeliki\|Camargo, Fernando\|Adams, David J\|Iavarone, Antoni
PMID:	28003334

127.
Journal:	Oncotarget. 2017 Feb 7;8(6):9280-9292.
Title:	Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.
Author:	Li, Xiangyun\|Li, Mei\|Ruan, Hang\|Qiu, Wei\|Xu, Xiang\|Zhang, Lin\|Yu, Jian
PMID:	28030835

128.
Journal:	Cancer Res. 2017 May 1;77(9):2512-2521.
Title:	Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells.
Author:	Tong, Jingshan\|Wang, Peng\|Tan, Shuai\|Chen, Dongshi\|Nikolovska-Coleska, Zaneta\|Zou, Fangdong\|Yu, Jian\|Zhang, Lin
PMID:	28202514

129.
Journal:	Exp Biol Med (Maywood). 2017 May;242(10):1034-1043.
Title:	The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
Author:	Gao, Chang\|Sun, Rui\|Xie, Ya-Rong\|Jiang, An-Li\|Lin, Mei\|Li, Min\|Chen, Zheng-Wang\|Zhang, Ping\|Jin, Honglin\|Feng, Jue-Ping
PMID:	28492347

130.
Journal:	Mol Cancer Ther. 2017 Oct;16(10):2178-2190.
Title:	A Novel Combination Treatment Targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified Colorectal Cancers.
Author:	Cho, Sung-Yup\|Han, Jee Yun\|Na, Deukchae\|Kang, Wonyoung\|Lee, Ahra\|Kim, Jooyoung\|Lee, Jieun\|Min, Seoyeon\|Kang, Jinjoo\|Chae, Jeesoo\|Kim, Jong-Il\|Park, Hansoo\|Lee, Won-Suk\|Lee, Charles
PMID:	28611106

131.
Journal:	Mol Cancer Ther. 2017 Sep;16(9):1979-1988.
Title:	FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.
Author:	Tong, Jingshan\|Tan, Shuai\|Nikolovska-Coleska, Zaneta\|Yu, Jian\|Zou, Fangdong\|Zhang, Lin
PMID:	28619760

132.
Journal:	Oncotarget. 2017 Apr 6;8(31):50642-50654.
Title:	Upregulation of microRNA-125b by G-CSF promotes metastasis in colorectal cancer.
Author:	Zhang, Xinghua\|Ma, Xiao\|An, Huaying\|Xu, Changqing\|Cao, Wenjo\|Yuan, Wei\|Ma, Jie
PMID:	28881590

133.
Journal:	Oncotarget. 2017 May 11;8(31):51478-51491.
Title:	Combination of Fe/Cu -chelators and docosahexaenoic acid: an exploration for the treatment of colorectal cancer.
Author:	Yu, Nanhui\|Zhu, Hong\|Yang, Yuan\|Tao, Yiming\|Tan, Fengbo\|Pei, Qian\|Zhou, Yuan\|Song, Xiangping\|Tan, Qiurong\|Pei, Haiping
PMID:	28881661

134.
Journal:	Biomed Pharmacother. 2017 Nov;95:1574-1579.
Title:	The BET-Bromodomain Inhibitor JQ1 synergized ABT-263 against colorectal cancer cells through suppressing c-Myc-induced miR-1271-5p expression.
Author:	Wu, Zhenqian\|Hu, Zedong\|Han, Xiaodong\|Li, Zhongnan\|Zhu, Qingchao\|Wang, Yu\|Zheng, Qi\|Yan, Jun
PMID:	28950657

135.
Journal:	Sci Rep. 2017 Nov 6;7(1):14571.
Title:	Involvement of autophagy in the outcome of mitotic catastrophe.
Author:	Sorokina, Irina V\|Denisenko, Tatiana V\|Imreh, Gabriela\|Tyurin-Kuzmin, Pyotr A\|Kaminskyy, Vitaliy O\|Gogvadze, Vladimir\|Zhivotovsky, Boris
PMID:	29109414

136.
Journal:	Oncotarget. 2017 Aug 2;8(59):99451-99469.
Title:	Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species.
Author:	Roberts, Jane L\|Poklepovic, Andrew\|Booth, Laurence
PMID:	29245915

137.
Journal:	Gen Physiol Biophys. 2017 Dec;36(5):539-547.
Title:	Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737.
Author:	Stefanikova, Andrea\|Klacanova, Katarina\|Pilchova, Ivana\|Hatok, Jozef\|Racay, Peter
PMID:	29372687

138.
Journal:	Mol Oncol. 2018 Mar;12(3):287-304.
Title:	Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Author:	Whittaker, Steven R\|Barlow, Clare\|Martin, Mathew P\|Mancusi, Caterina\|Wagner, Steve\|Self, Annette\|Barrie, Elaine\|Te Poele, Robert\|Sharp, Swee\|Brown, Nathan\|Wilson, Stuart\|Jackson, Wayne\|Fischer, Peter M\|Clarke, Paul A\|Walton, Michael I\|McDonald, Edward\|Bla
PMID:	29063678

139.
Journal:	Mol Carcinog. 2018 Feb;57(2):284-294.
Title:	BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922.
Author:	Wang, Chun Yan\|Guo, Su Tang\|Croft, Amanda\|Yan, Xu Guang\|Jin, Lei\|Zhang, Xu Dong\|Jiang, Chen Chen
PMID:	29068469

140.
Journal:	Cancer Biol Ther. 2018 Jun 3;19(6):465-474.
Title:	DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a.
Author:	Zhou, Yalu\|Perez, Ricardo E\|Duan, Lei\|Maki, Carl G
PMID:	29394130

141.
Journal:	Pharmacogn Mag. 2018 Jan;13(Suppl 4):S801-S806.
Title:	Viwithan, a Standardized Withania somnifera Root Extract Induces Apoptosis in Murine Melanoma Cells.
Author:	Sudeep, H V\|Gouthamchandra, K\|Venkatesh, B J\|Prasad, K Shyam
PMID:	29491636

142.
Journal:	Int J Oncol. 2018 Mar 7.
Title:	Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer.
Author:	Maeda, Yuzo\|Takahashi, Hiroki\|Nakai, Nozomu\|Yanagita, Takeshi\|Ando, Nanako\|Okubo, Tomotaka\|Saito, Kenta\|Shiga, Kazuyoshi\|Hirokawa, Takahisa\|Hara, Masayasu\|Ishiguro, Hideyuki\|Matsuo, Yoichi\|Takiguchi, Shuji
PMID:	29512707

143.
Journal:	Mol Cancer Ther. 2018 May;17(5):977-987.
Title:	A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-kappaB Signaling in KRAS-Mutant Colon Cancer Cells.
Author:	Inoue, Akira\|Mizushima, Tsunekazu\|Wu, Xin\|Okuzaki, Daisuke\|Kambara, Nanami\|Ishikawa, Sho\|Wang, Jiaqi\|Qian, Yamin\|Hirose, Haruka\|Yokoyama, Yuhki\|Ikeshima, Ryo\|Hiraki, Masayuki\|Miyoshi, Norikatsu\|Takahashi, Hidekazu\|Haraguchi, Naotsugu\|Hata, Taishi\|Matsuda,
PMID:	29545333

144.
Journal:	Oncol Lett. 2018 May;15(5):8019-8026.
Title:	Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells.
Author:	Dai, Xiao-Yu\|Zhou, Bao-Feng\|Xie, Yang-Yang\|Lou, Jie\|Li, Ke-Qiang
PMID:	29849804

145.
Journal:	Cancer Res. 2018 Aug 15;78(16):4704-4715.
Title:	Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins.
Author:	Tong, Jingshan\|Zheng, Xingnan\|Tan, Xiao\|Fletcher, Rochelle\|Nikolovska-Coleska, Zaneta\|Yu, Jian\|Zhang, Lin
PMID:	29895675

146.
Journal:	Mol Cancer Res. 2018 Sep 10. pii: 1541-7786.MCR-18-0650.
Title:	Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition.
Author:	Mattoo, Abid R\|Joun, Alex\|Jessup, J Milburn
PMID:	30201826

147.
Journal:	Eur J Med Chem. 2018 Sep 13;158:896-916.
Title:	Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4- yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.
Author:	Wang, Beilei\|Wu, Jiaxin\|Wu, Yun\|Chen, Cheng\|Zou, Fengming\|Wang, Aoli\|Wu, Hong\|Hu, Zhenquan\|Jiang, Zongru\|Liu, Qingwang\|Wang, Wei\|Zhang, Yicong\|Liu, Feiyang\|Zhao, Ming\|Hu, Jie\|Huang, Tao\|Ge, Juan\|Wang, Li\|Ren, Tao\|Wang, Yuxin\|Liu, Jing\|Liu, Qingsong
PMID:	30253346

148.
Journal:	Oncogene. 2018 Oct 22. pii: 10.1038/s41388-018-0547-y.
Title:	Targeting colon cancer with the novel STAT3 inhibitor bruceantinol.
Author:	Wei, Ning\|Li, Jun\|Fang, Cheng\|Chang, Jin\|Xirou, Vasiliki\|Syrigos, Nick K\|Marks, Benjamin J\|Chu, Edward\|Schmitz, John C
PMID:	30348989

149.
Journal:	J Gastroenterol Hepatol. 2018 Oct 30.
Title:	Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling.
Author:	Kim, Young Hoon\|Kim, Jee Hyun\|Kim, Byeong Gwan\|Lee, Kook Lae\|Kim, Ji Won\|Koh, Seong-Joon
PMID:	30378164