Primary Site >> Colorectal Cancer
Gene >> MCL1
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Ref: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. PMID: 8625322 Ref: Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. PMID: 8938795 |
Ref: 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PMID: 11300326 Ref: Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. PMID: 11484952 Ref: E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells. PMID: 11705881 |
Ref: Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases. PMID: 11896073 |
Ref: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. PMID: 12818369 Ref: 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. PMID: 12842827 |
Ref: Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production. PMID: 15163544 Ref: Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis. PMID: 15527805 |
Ref: Changes in Mcl-1 expression in rectal cancer in relation to neo-adjuvant radiotherapy. PMID: 15847193 Ref: Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. PMID: 16083714 Ref: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. PMID: 16192633 |
Ref: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. PMID: 17102938 Ref: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. PMID: 17113582 |
Ref: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. PMID: 16901994 Ref: STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation. PMID: 17264243 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: Clearing the TRAIL for Cancer Therapy. PMID: 17613431 Ref: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. PMID: 17804748 |
Ref: Differential sensitivity of human colon cancer cell lines to the nucleoside analogs ARC and DRB. PMID: 17999411 Ref: WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers. PMID: 18035333 Ref: The antiapoptotic role of pregnane X receptor in human colon cancer cells. PMID: 18096695 Ref: Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. PMID: 18292181 Ref: Inhibition of proteasomal degradation of Mcl-1 by cobalt chloride suppresses cobalt chloride-induced apoptosis in HCT116 colorectal cancer cells. PMID: 18543107 Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. PMID: 18560353 Ref: Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells. PMID: 18609706 Ref: Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. PMID: 18663430 Ref: A critical role for Apc in hematopoietic stem and progenitor cell survival. PMID: 18725524 Ref: Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin. PMID: 18771933 Ref: Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. PMID: 19088028 |
Ref: Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs. PMID: 19156717 Ref: HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins. PMID: 19179333 Ref: Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. PMID: 19380879 Ref: The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells. PMID: 19862414 |
Ref: Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. PMID: 20090905 Ref: Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo. PMID: 20137855 Ref: PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. PMID: 20150631 Ref: Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. PMID: 20397199 Ref: Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. PMID: 20424169 Ref: Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria. PMID: 20462271 Ref: Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells. PMID: 20534983 Ref: Fucoidan present in brown algae induces apoptosis of human colon cancer cells. PMID: 20727207 Ref: CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. PMID: 20877573 Ref: Correlation between Mcl-1 and pAKT protein expression in colorectal cancer. PMID: 21151390 |
Ref: Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1. PMID: 21241418 Ref: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. PMID: 21368833 Ref: Hypoxic human cancer cells are sensitized to BH-3 mimetic-induced apoptosis via downregulation of the Bcl-2 protein Mcl-1. PMID: 21393866 Ref: High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde. PMID: 21513580 Ref: Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells. PMID: 21519792 Ref: Expression of the antiapoptotic protein survivin in colon cancer. PMID: 21855041 Ref: The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells. PMID: 22006676 Ref: Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors. PMID: 22078414 Ref: Cellular signal transduction pathways by leptin in colorectal cancer tissue: preliminary results. PMID: 22363883 |
Ref: Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells. PMID: 21901254 Ref: Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. PMID: 22056880 Ref: The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. PMID: 22170686 Ref: Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad. PMID: 22179721 Ref: N-alpha-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression. PMID: 22496479 Ref: The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells. PMID: 22555452 Ref: Inhibition of GSK-3beta reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells. PMID: 22683934 Ref: Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation. PMID: 22895172 Ref: Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. PMID: 22965228 |
Ref: MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. PMID: 22824797 Ref: Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL. PMID: 23132258 Ref: MiR-125a/b regulates the activation of cancer stem cells in paclitaxel-resistant colon cancer. PMID: 23327190 Ref: External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-kB and induces cell cycle arrest and apoptosis in colorectal cancer cells. PMID: 23363659 Ref: The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms. PMID: 23456623 Ref: Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-alpha, Caspase-8, Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro. PMID: 23525225 Ref: The novel BH3 alpha-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. PMID: 23680104 Ref: Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells. PMID: 23799546 Ref: Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells. PMID: 23887890 Ref: The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. PMID: 23983126 Ref: Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737. PMID: 24030153 Ref: Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. PMID: 24098503 Ref: Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263. PMID: 24126433 Ref: Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. PMID: 24399733 |
Ref: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. PMID: 24163374 Ref: Caffeine inhibits paclitaxelinduced apoptosis in colorectal cancer cells through the upregulation of Mcl1 levels. PMID: 24173825 Ref: Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation. PMID: 24363449 Ref: Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. PMID: 24556425 Ref: Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. PMID: 24576621 Ref: BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737. PMID: 24709422 Ref: Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. PMID: 24743574 Ref: Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells. PMID: 24812029 Ref: Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PMID: 25192188 Ref: Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. PMID: 25200342 Ref: Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimetics. PMID: 25208882 Ref: Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway. PMID: 25285768 Ref: Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak. PMID: 25304383 Ref: Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. PMID: 25386076 |
Ref: Role of miR-15/16 in CLL. PMID: 24971479 Ref: Dichloroacetate affects proliferation but not survival of human colorectal cancer cells. PMID: 25344893 Ref: BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer. PMID: 25388617 Ref: HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. PMID: 25446253 Ref: MicroRNA-29b is a Novel Prognostic Marker in Colorectal Cancer. PMID: 25472644 Ref: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. PMID: 25548100 Ref: Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. PMID: 25565667 Ref: Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer. PMID: 25628923 Ref: FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells. PMID: 25843953 Ref: Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer. PMID: 26134786 Ref: miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1. PMID: 26297542 Ref: ApoG2 inhibits the antiapoptotic protein, Mcl1, and induces mitochondriadependent apoptosis in human colorectal cancer cells. PMID: 26352605 Ref: Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. PMID: 26392303 Ref: Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. PMID: 26485768 Ref: Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy. PMID: 26561209 Ref: Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling. PMID: 26585594 Ref: Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway. PMID: 26592508 |
Ref: Identifying molecular subtypes in human colon cancer using gene expression and DNA methylation microarray data. PMID: 26647925 Ref: Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing. PMID: 26864447 Ref: AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin. PMID: 26918349 Ref: Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways. PMID: 26918455 Ref: Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells. PMID: 26921340 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. PMID: 27351224 Ref: Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. PMID: 27421828 Ref: BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. PMID: 27429848 Ref: Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells. PMID: 27461218 Ref: Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. PMID: 27512955 Ref: Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. PMID: 27517746 Ref: Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1. PMID: 27581253 Ref: Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. PMID: 27765849 Ref: TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. PMID: 27818144 |
Ref: FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. PMID: 27399335 Ref: The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis. PMID: 27941883 Ref: HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. PMID: 28003334 Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. PMID: 28202514 Ref: The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo. PMID: 28492347 Ref: A Novel Combination Treatment Targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified Colorectal Cancers. PMID: 28611106 Ref: FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. PMID: 28619760 Ref: Upregulation of microRNA-125b by G-CSF promotes metastasis in colorectal cancer. PMID: 28881590 Ref: Combination of Fe/Cu -chelators and docosahexaenoic acid: an exploration for the treatment of colorectal cancer. PMID: 28881661 Ref: The BET-Bromodomain Inhibitor JQ1 synergized ABT-263 against colorectal cancer cells through suppressing c-Myc-induced miR-1271-5p expression. PMID: 28950657 Ref: Involvement of autophagy in the outcome of mitotic catastrophe. PMID: 29109414 Ref: Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. PMID: 29245915 Ref: Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737. PMID: 29372687 |
Ref: Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. PMID: 29063678 Ref: BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922. PMID: 29068469 Ref: DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. PMID: 29394130 Ref: Viwithan, a Standardized Withania somnifera Root Extract Induces Apoptosis in Murine Melanoma Cells. PMID: 29491636 Ref: Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. PMID: 29512707 Ref: A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-kappaB Signaling in KRAS-Mutant Colon Cancer Cells. PMID: 29545333 Ref: Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells. PMID: 29849804 Ref: Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. PMID: 29895675 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition. PMID: 30201826 Ref: Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4- yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. PMID: 30253346 Ref: Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. PMID: 30348989 Ref: Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling. PMID: 30378164 |