Primary Site >> Biliary tract Cancer

Gene >> MCL1

Journal: Gut. 2002 Oct;51(4):556-61.
Title: Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells.
Author: Okaro, A C|Fennell, D A|Corbo, M|Davidson, B R|Cotter, F E
PMID: 12235080
Journal: Hepatology. 2002 Mar;35(3):552-9.
Title: COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells.
Author: Nzeako, Ugochukwu C|Guicciardi, Maria Eugenia|Yoon, Jung-Hwan|Bronk, Steven F|Gores, Gregory J
PMID: 11870367
Journal: Cancer Res. 2004 May 15;64(10):3517-24.
Title: Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
Author: Taniai, Makiko|Grambihler, Annette|Higuchi, Hajime|Werneburg, Nate|Bronk, Steve F|Farrugia, Daniel J|Kaufmann, Scott H|Gores, Gregory J
PMID: 15150106
Journal: Liver Int. 2004 Dec;24(6):687-95.
Title: Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells.
Author: Chiorean, Mihnea V|Guicciardi, Maria Eugenia|Yoon, Jung-Hwan|Bronk, Steven F|Kaufmanns, Scott H|Gores, Gregory J
PMID: 15566522
Journal: Hepatology. 2005 Dec;42(6):1329-38.
Title: Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells.
Author: Isomoto, Hajime|Kobayashi, Shogo|Werneburg, Nathan W|Bronk, Steve F|Guicciardi, Maria Eugenia|Frank, David A|Gores, Gregory J
PMID: 16317687
Journal: J Hepatol. 2006 Jun;44(6):1055-65.
Title: Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes.
Author: Meng, Fanyin|Yamagiwa, Yoko|Ueno, Yoshiyuki|Patel, Tushar
PMID: 16469407
Journal: Gastroenterology. 2007 Jan;132(1):384-96.
Title: Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
Author: Isomoto, Hajime|Mott, Justin L|Kobayashi, Shogo|Werneburg, Nathan W|Bronk, Steve F|Haan, Serge|Gores, Gregory J
PMID: 17241887
Journal: Mol Cancer Ther. 2008 Aug;7(8):2339-47.
Title: BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis.
Author: Mott, Justin L|Bronk, Steve F|Mesa, Ruben A|Kaufmann, Scott H|Gores, Gregory J
PMID: 18723481
Journal: J Hepatol. 2009 Feb;50(2):358-69.
Title: The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma.
Author: Chen, Lei|Yan, He-Xin|Yang, Wen|Hu, Liang|Yu, Le-Xin|Liu, Qiong|Li, Liang|Huang, Dan-Dan|Ding, Jin|Shen, Feng|Zhou, Wei-Ping|Wu, Meng-Chao|Wang, Hong-Yang
PMID: 19070389
Journal: Hepatology. 2009 Dec;50(6):1861-70.
Title: Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.
Author: Blechacz, Boris R A|Smoot, Rory L|Bronk, Steven F|Werneburg, Nathan W|Sirica, Alphonse E|Gores, Gregory J
PMID: 19821497
Journal: Cancer Invest. 2010 Jun;28(5):472-8.
Title: Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma.
Author: Fingas, Christian Dominik|Katsounas, Antonios|Kahraman, Alisan|Siffert, Winfried|Jochum, Christoph|Gerken, Guido|Nuckel, Holger|Canbay, Ali
PMID: 19968497
Journal: Cancer Chemother Pharmacol. 2011 Mar;67(3):557-67.
Title: The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid.
Author: Romani, Antonello A|Desenzani, Silvia|Morganti, Marina M|Baroni, Maria Cristina|Borghetti, Angelo F|Soliani, Paolo
PMID: 20473610
Journal: Oncologist. 2014 Mar;19(3):235-42.
Title: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.
Author: Ross, Jeffrey S|Wang, Kai|Gay, Laurie|Al-Rohil, Rami|Rand, Janne V|Jones, David M|Lee, Hwa J|Sheehan, Christine E|Otto, Geoff A|Palmer, Gary|Yelensky, Roman|Lipson, Doron|Morosini, Deborah|Hawryluk, Matthew|Catenacci, Daniel V T|Miller, Vincent A|Churi, C
PMID: 24563076
Journal: Chin Med J (Engl). 2014;127(14):2637-42.
Title: Expressions of farnesoid X receptor and myeloid cell leukemia sequence 1 protein are associated with poor prognosis in patients with gallbladder cancer.
Author: Wang, Wei|Yin, Xiaobin|Li, Guiping|Yi, Jing|Wang, Jian
PMID: 25043081
Journal: PLoS One. 2014 Dec 23;9(12):e115383.
Title: Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.
Author: Churi, Chaitanya R|Shroff, Rachna|Wang, Ying|Rashid, Asif|Kang, HyunSeon C|Weatherly, Jacqueline|Zuo, Mingxin|Zinner, Ralph|Hong, David|Meric-Bernstam, Funda|Janku, Filip|Crane, Christopher H|Mishra, Lopa|Vauthey, Jean-Nicholas|Wolff, Robert A|Mills, Gord
PMID: 25536104
Journal: Exp Biol Med (Maywood). 2015 Feb;240(2):252-60.
Title: Ursodeoxycholyl lysophosphatidylethanolamide inhibits cholestasis- and hypoxia-induced apoptosis by upregulating antiapoptosis proteins.
Author: Sellinger, Myra|Xu, Weihong|Pathil, Anita|Stremmel, Wolfgang|Chamulitrat, Walee
PMID: 25125499
Journal: Exp Cell Res. 2015 Jul 1;335(1):68-81.
Title: ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics.
Author: Fan, Zhongqi|Yu, Huimei|Cui, Ni|Kong, Xianggui|Liu, Xiaomin|Chang, Yulei|Wu, Yao|Sun, Liankun|Wang, Guangyi
PMID: 25936772
Journal: Acta Pharmacol Sin. 2015 Dec;36(12):1514-9.
Title: Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway.
Author: Su, Li-ya|Shi, Ying-xu|Yan, Mei-rong|Xi, Yaguang|Su, Xiu-lan
PMID: 26592508
Journal: Oncol Lett. 2016 Jan;11(1):474-480. Epub 2015 Nov 6.
Title: The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine.
Author: Li, Qiwei|Yin, Xiaobin|Wang, Wei|Zhan, Ming|Zhao, Benpeng|Hou, Zhaoyuan|Wang, Jian
PMID: 26870236
Journal: J Hepatobiliary Pancreat Sci. 2016 Jul;23(7):397-405.
Title: Anoikis-resistant cholangiocarcinoma cells display aggressive characteristics and increase STAT3 activation.
Author: Huyen, Nguyen Thi Bich|Prachayasittikul, Virapong|Chan-On, Waraporn
PMID: 27107220
Journal: J Cell Mol Med. 2016 Dec;20(12):2299-2308.
Title: The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer.
Author: Wang, Shou-Hua|Zhang, Wen-Jie|Wu, Xiao-Cai|Weng, Ming-Zhe|Zhang, Ming-Di|Cai, Qiang|Zhou, Di|Wang, Jian-Dong|Quan, Zhi-Wei
PMID: 27420766
Journal: J Hepatol. 2018 Jun;68(6):1228-1238.
Title: Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma.
Author: Kabashima, Ayano|Hirsova, Petra|Bronk, Steven F|Hernandez, Matthew C|Truty, Mark J|Rizvi, Sumera|Kaufmann, Scott H|Gores, Gregory J
PMID: 29408314