Primary Site >> Biliary tract Cancer

Gene >> MCL1

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Ref: COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells.
PMID: 11870367
Ref: Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells.
PMID: 12235080
Ref: Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
PMID: 15150106
Ref: Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells.
PMID: 15566522
Ref: Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells.
PMID: 16317687
Ref: Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes.
PMID: 16469407
Ref: Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
PMID: 17241887
Ref: BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis.
PMID: 18723481
Ref: The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma.
PMID: 19070389
Ref: Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.
PMID: 19821497
Ref: Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma.
PMID: 19968497
Ref: The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid.
PMID: 20473610
Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.
PMID: 24563076
Ref: Expressions of farnesoid X receptor and myeloid cell leukemia sequence 1 protein are associated with poor prognosis in patients with gallbladder cancer.
PMID: 25043081
Ref: Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.
PMID: 25536104
Ref: Ursodeoxycholyl lysophosphatidylethanolamide inhibits cholestasis- and hypoxia-induced apoptosis by upregulating antiapoptosis proteins.
PMID: 25125499
Ref: ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics.
PMID: 25936772
Ref: Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway.
PMID: 26592508
Ref: The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine.
PMID: 26870236
Ref: Anoikis-resistant cholangiocarcinoma cells display aggressive characteristics and increase STAT3 activation.
PMID: 27107220
Ref: The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer.
PMID: 27420766
Ref: Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma.
PMID: 29408314