Primary Site >> Colorectal Cancer

Gene >> MAPK7

Journal: J Biol Chem. 2002 Dec 13;277(50):48755-63. Epub 2002 Sep 17.
Title: Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor.
Author: Guo, Yan-Shi|Cheng, Ji-Zhong|Jin, Gui-Fang|Gutkind, J Silvio|Hellmich, Mark R|Townsend, Courtney M Jr
PMID: 12239223
Journal: Gene. 2002 Feb 20;285(1-2):175-82.
Title: Genomic structure of the human NLK (nemo-like kinase) gene and analysis of its promoter region.
Author: Harada, Haruhito|Yoshida, Shoko|Nobe, Yukiko|Ezura, Yoichi|Atake, Tomoko|Koguchi, Tomoko|Emi, Mitsuru
PMID: 12039044
Journal: Oncol Rep. 2006 Oct;16(4):845-50.
Title: MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers.
Author: Akao, Yukihiro|Nakagawa, Yoshihito|Naoe, Tomoki
PMID: 16969504
Journal: Bioorg Med Chem. 2007 Aug 15;15(16):5620-8. Epub 2007 May 18.
Title: Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells.
Author: Nakagawa, Yoshihito|Iinuma, Munekazu|Naoe, Tomoki|Nozawa, Yoshinori|Akao, Yukihiro
PMID: 17553685
Journal: Oncogene. 2007 Sep 6;26(41):6071-81. Epub 2007 Jul 30.
Title: Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.
Author: Moniz, S|Verissimo, F|Matos, P|Brazao, R|Silva, E|Kotelevets, L|Chastre, E|Gespach, C|Jordan, P
PMID: 17667937
Journal: Cancer Sci. 2007 Dec;98(12):1914-20. Epub 2007 Sep 24.
Title: Downregulation of microRNAs-143 and -145 in B-cell malignancies.
Author: Akao, Yukihiro|Nakagawa, Yoshihito|Kitade, Yukio|Kinoshita, Tomohiro|Naoe, Tomoki
PMID: 17892514
Journal: Mol Cell Biochem. 2009 Aug;328(1-2):201-8.
Title: MAP kinases in proliferating human colon cancer Caco-2 cells.
Author: Buzzi, Natalia|Colicheo, Andrea|Boland, Ricardo|de Boland, Ana Russo
PMID: 19301097
Journal: Leuk Res. 2009 Nov;33(11):1530-8.
Title: Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells.
Author: Akao, Yukihiro|Nakagawa, Yoshihito|Iio, Akio|Naoe, Tomoki
PMID: 19464056
Journal: Tumour Biol. 2011 Oct;32(5):965-76.
Title: Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells.
Author: Dabrowska, Magdalena|Skoneczny, Marek|Rode, Wojciech
PMID: 21678067
Journal: Cancer Res. 2011 Aug 1;71(15):5214-24.
Title: MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma.
Author: Ibrahim, Ahmed Fawzy|Weirauch, Ulrike|Thomas, Maren|Grunweller, Arnold|Hartmann, Roland K|Aigner, Achim
PMID: 21690566
Journal: PLoS One. 2011;6(8):e23787.
Title: miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation.
Author: Borralho, Pedro M|Simoes, Andre E S|Gomes, Sofia E|Lima, Raquel T|Carvalho, Tania|Ferreira, Duarte M S|Vasconcelos, Maria H|Castro, Rui E|Rodrigues, Cecilia M P
PMID: 21901135
Journal: PLoS One. 2012;7(8):e42137.
Title: Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice.
Author: Takaoka, Yuji|Shimizu, Yuko|Hasegawa, Hitoki|Ouchi, Yasuo|Qiao, Shanlou|Nagahara, Miki|Ichihara, Masatoshi|Lee, Jiing-Dwan|Adachi, Koichi|Hamaguchi, Michinari|Iwamoto, Takashi
PMID: 22876303
Journal: Mol Cancer Ther. 2012 Nov;11(11):2311-20.
Title: Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.
Author: Gierut, Jessica J|Mathur, Priya S|Bie, Wenjun|Han, Jin|Tyner, Angela L
PMID: 22989419
Journal: Oncol Lett. 2013 Nov;6(5):1333-1337.
Title: Overexpression of MEKK2 is associated with colorectal carcinogenesis.
Author: Jiang, Li|Huang, Meijin|Wang, Lei|Fan, Xinjuan|Wang, Puning|Wang, Daohai|Fu, Xinhui|Wang, Jianping
PMID: 24179519
Journal: Cancer Immunol Res. 2014 Aug;2(8):789-99.
Title: Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.
Author: Jiang, Hong|Wang, Ping|Li, Xiaohua|Wang, Qilong|Deng, Zhong-Bin|Zhuang, Xiaoying|Mu, Jingyao|Zhang, Lifeng|Wang, Baomei|Yan, Jun|Miller, Donald|Zhang, Huang-Ge
PMID: 24801835
Journal: J Nat Prod. 2014 Aug 22;77(8):1825-30.
Title: 6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells.
Author: Mansoor, Tayyab A|Borralho, Pedro M|Luo, Xuan|Mulhovo, Silva|Rodrigues, Cecilia M P|Ferreira, Maria-Jose U
PMID: 25066282
Journal: Phytomedicine. 2014 Jul-Aug;21(8-9):1070-7.
Title: Propolis cinnamic acid derivatives induce apoptosis through both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA expression.
Author: Kumazaki, Minami|Shinohara, Haruka|Taniguchi, Kohei|Yamada, Nami|Ohta, Shozo|Ichihara, Kenji|Akao, Yukihiro
PMID: 24854570
Journal: Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G179-87.
Title: Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Author: Pekow, Joel|Meckel, Katherine|Dougherty, Urszula|Butun, Fatma|Mustafi, Reba|Lim, John|Crofton, Charis|Chen, Xindi|Joseph, Loren|Bissonnette, Marc
PMID: 25477374
Journal: FEBS J. 2015 Apr;282(8):1394-405.
Title: SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling.
Author: Mansour, Mohammed A|Hyodo, Toshinori|Ito, Satoko|Kurita, Kenji|Kokuryo, Toshio|Uehara, Keisuke|Nagino, Masato|Takahashi, Masahide|Hamaguchi, Michinari|Senga, Takeshi
PMID: 25662172
Journal: Cell Death Dis. 2015 Apr 9;6:e1718.
Title: Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-kappaB activation.
Author: Simoes, A E S|Pereira, D M|Gomes, S E|Brito, H|Carvalho, T|French, A|Castro, R E|Steer, C J|Thibodeau, S N|Rodrigues, C M P|Borralho, P M
PMID: 25855966
Journal: Onco Targets Ther. 2015 Jul 8;8:1691-9.
Title: Screening of potential diagnostic markers and therapeutic targets against colorectal cancer.
Author: Tian, XiaoQing|Sun, DanFeng|Zhao, ShuLiang|Xiong, Hua|Fang, JingYuan
PMID: 26185457
Journal: Oncotarget. 2016 Jan 26;7(4):4993-5006.
Title: SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer.
Author: Mansour, Mohammed A|Hyodo, Toshinori|Akter, Khondker Ayesha|Kokuryo, Toshio|Uehara, Keisuke|Nagino, Masato|Senga, Takeshi
PMID: 26701851
Journal: Cell Cycle. 2016;15(4):506-18.
Title: Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Author: Lochhead, Pamela A|Clark, Jonathan|Wang, Lan-Zhen|Gilmour, Lesley|Squires, Matthew|Gilley, Rebecca|Foxton, Caroline|Newell, David R|Wedge, Stephen R|Cook, Simon J
PMID: 26959608
Journal: Mol Cancer Res. 2016 Jun;14(6):563-73.
Title: Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.
Author: Mathur, Priya S|Gierut, Jessica J|Guzman, Grace|Xie, Hui|Xicola, Rosa M|Llor, Xavier|Chastkofsky, Michael I|Perekatt, Ansu O|Tyner, Angela L
PMID: 26983689
Journal: Oncotarget. 2016 Jun 7;7(23):34322-40.
Title: MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism.
Author: Pereira, Diane M|Simoes, Andre E S|Gomes, Sofia E|Castro, Rui E|Carvalho, Tania|Rodrigues, Cecilia M P|Borralho, Pedro M
PMID: 27144434
Journal: Nat Commun. 2016 May 17;7:11551.
Title: ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.
Author: de Jong, Petrus R|Taniguchi, Koji|Harris, Alexandra R|Bertin, Samuel|Takahashi, Naoki|Duong, Jen|Campos, Alejandro D|Powis, Garth|Corr, Maripat|Karin, Michael|Raz, Eyal
PMID: 27187615
Journal: Cell Death Dis. 2016 Oct 13;7(10):e2415.
Title: CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5-AP-1 axis.
Author: Zhuang, Kangmin|Zhang, Juchang|Xiong, Man|Wang, Xianfei|Luo, Xiaobei|Han, Lu|Meng, Yan|Zhang, Yali|Liao, Wenting|Liu, Side
PMID: 27735944
Journal: Exp Cell Res. 2018 Feb 15;363(2):235-242.
Title: Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/beta-Catenin pathway.
Author: Cheng, Fei|Mohanmed, Mohamed Mohanoud|Li, Zhenjia|Zhu, Liang|Zhang, Qiansen|Huang, Qiang|Shen, Wei
PMID: 29331389