Primary Site >> Colorectal Cancer
Gene >> MAPK7
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Ref: Genomic structure of the human NLK (nemo-like kinase) gene and analysis of its promoter region. PMID: 12039044 Ref: Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. PMID: 12239223 |
Ref: MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers. PMID: 16969504 |
Ref: Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. PMID: 17553685 Ref: Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. PMID: 17667937 Ref: Downregulation of microRNAs-143 and -145 in B-cell malignancies. PMID: 17892514 |
Ref: MAP kinases in proliferating human colon cancer Caco-2 cells. PMID: 19301097 Ref: Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells. PMID: 19464056 |
Ref: Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. PMID: 21678067 Ref: MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. PMID: 21690566 Ref: miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation. PMID: 21901135 |
Ref: Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PMID: 22876303 Ref: Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. PMID: 22989419 |
Ref: Overexpression of MEKK2 is associated with colorectal carcinogenesis. PMID: 24179519 |
Ref: Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2. PMID: 24801835 Ref: Propolis cinnamic acid derivatives induce apoptosis through both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA expression. PMID: 24854570 Ref: 6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells. PMID: 25066282 |
Ref: Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon. PMID: 25477374 Ref: SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling. PMID: 25662172 Ref: Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-kappaB activation. PMID: 25855966 Ref: Screening of potential diagnostic markers and therapeutic targets against colorectal cancer. PMID: 26185457 |
Ref: SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer. PMID: 26701851 Ref: Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation. PMID: 26959608 Ref: Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. PMID: 26983689 Ref: MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. PMID: 27144434 Ref: ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. PMID: 27187615 Ref: CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5-AP-1 axis. PMID: 27735944 |
Ref: Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/beta-Catenin pathway. PMID: 29331389 |