Primary Site >> Esophagus Cancer

Gene >> MAPK3

Journal: J Biol Chem. 2001 May 4;276(18):15537-46. Epub 2001 Jan 31.
Title: Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.
Author: Barry, O P|Mullan, B|Sheehan, D|Kazanietz, M G|Shanahan, F|Collins, J K|O'Sullivan, G C
PMID: 11297525
Journal: Biochem Pharmacol. 2004 May 1;67(9):1701-10.
Title: Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.
Author: Sutter, Andreas P|Maaser, Kerstin|Gerst, Bastian|Krahn, Antje|Zeitz, Martin|Scherubl, Hans
PMID: 15081869
Journal: J Biol Chem. 2004 Dec 3;279(49):50676-83. Epub 2004 Sep 16.
Title: The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation.
Author: Chang, Mei-Chi|Wu, Hui-Lin|Lee, Jang-Jaer|Lee, Po-Hsuen|Chang, Hsiao-Hwa|Hahn, Liang-Jiunn|Lin, Bor-Ru|Chen, Yi-Jane|Jeng, Jiiang-Huei
PMID: 15375172
Journal: Oncogene. 2005 Dec 15;24(56):8268-76.
Title: Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression.
Author: Song, Shumei|Lippman, Scott M|Zou, Yiyu|Ye, Xiaofeng|Ajani, Jaffer A|Xu, Xiao-Chun
PMID: 16170369
Journal: Int J Cancer. 2006 Apr 1;118(7):1814-22.
Title: Targeting the epidermal growth factor receptor by erlotinib (Tarceva) for the treatment of esophageal cancer.
Author: Sutter, Andreas P|Hopfner, Michael|Huether, Alexander|Maaser, Kerstin|Scherubl, Hans
PMID: 16217753
Journal: J Surg Res. 2006 Jul;134(1):1-9. Epub 2006 Feb 20.
Title: Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model.
Author: Sui, Guoping|Bonde, Pramod|Dhara, Surajit|Broor, Apoorv|Wang, Jiaai|Marti, Guy|Feldmann, Georg|Duncan, Mark|Montgomery, Elizabeth|Maitra, Anirban|Harmon, John W
PMID: 16488438
Journal: Cancer Res. 2006 Mar 15;66(6):3071-7.
Title: A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer.
Author: Wang, Bo|Hendricks, Denver T|Wamunyokoli, Fred|Parker, M Iqbal
PMID: 16540656
Journal: Cancer Res. 2006 Jul 15;66(14):7111-8.
Title: RRIG1 mediates effects of retinoic acid receptor beta2 on tumor cell growth and gene expression through binding to and inhibition of RhoA.
Author: Liang, Zheng D|Lippman, Scott M|Wu, Tsung-Teh|Lotan, Reuben|Xu, Xiao-Chun
PMID: 16849557
Journal: Mol Cell Biol. 2008 Jun;28(12):4142-51.
Title: Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
Author: Miller, Anna V|Alvarez, Sergio E|Spiegel, Sarah|Lebman, Deborah A
PMID: 18426913
Journal: J Cell Biochem. 2008 Sep 1;105(1):53-60.
Title: Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway.
Author: Liu, Xuan|Wu, William K K|Yu, Le|Sung, Joseph J Y|Srivastava, Gopesh|Zhang, Shu T|Cho, Chi H
PMID: 18452159
Journal: BMC Cancer. 2009 Jun 17;9:190.
Title: Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells.
Author: Looby, Eileen|Abdel-Latif, Mohamed M M|Athie-Morales, Veronica|Duggan, Shane|Long, Aideen|Kelleher, Dermot
PMID: 19534809
Journal: J Biol Chem. 2009 Mar 20;284(12):7995-8004.
Title: Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells.
Author: Gao, Shu-Ying|Li, En-Min|Cui, Lei|Lu, Xiao-Feng|Meng, Ling-Ying|Yuan, Hua-Min|Xie, Jian-Jun|Du, Ze-Peng|Pang, Jian-Xin|Xu, Li-Yan
PMID: 19164283
Journal: Mol Cancer. 2010 Apr 28;9:93.
Title: Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A.
Author: Ye, Fei|Xu, Xiao-Chun
PMID: 20426865
Journal: Cell Mol Life Sci. 2010 Oct;67(19):3313-29.
Title: Specificity protein 1 regulates fascin expression in esophageal squamous cell carcinoma as the result of the epidermal growth factor/extracellular signal-regulated kinase signaling pathway activation.
Author: Lu, Xiao-Feng|Li, En-Min|Du, Ze-Peng|Xie, Jian-Jun|Guo, Zhang-Yan|Gao, Shu-Ying|Liao, Lian-Di|Shen, Zhong-Ying|Xie, Dong|Xu, Li-Yan
PMID: 20502940
Journal: Cell Physiol Biochem. 2010;26(6):849-58.
Title: Gensenoside Rg3 inhibits hypoxia-induced VEGF expression in human cancer cells.
Author: Chen, Qing-Jiang|Zhang, Ming-Zhi|Wang, Le-Xin
PMID: 21220916
Journal: Mol Biol Rep. 2011 Feb;38(2):865-72.
Title: The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706.
Author: Zheng, Shu-Tao|Huo, Qi|Tuerxun, Aerziguli|Ma, Wen-Jing|Lv, Guo-Dong|Huang, Cong-Gai|Liu, Qing|Wang, Xing|Lin, Ren-Yong|Sheyhidin, Ilyar|Lu, Xiao-Mei
PMID: 20464500
Journal: Anticancer Agents Med Chem. 2011 Sep;11(7):629-37.
Title: A novel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma.
Author: Ucar, Deniz A|Cox, Audrey|He, Di-Hua|Ostrov, David A|Kurenova, Elena|Hochwald, Steven N
PMID: 21707510
Journal: Zhonghua Zhong Liu Za Zhi. 2011 Jun;33(6):421-5.
Title: [Expression of ERK1/2 MAPK signaling transduction pathway in esophageal cancers in Kazakh patients].
Author: Zheng, Shu-tao|Liu, Tao|Middottuersun, Aerziguli|Huo, Qi|Liu, Qing|Huang, Cong-gai|Feng, Jun-guo|Lu, Guo-dong|Wang, Xing|Lin, Ren-Yong|Sheyhidin, Ilyar|Lu, Xiao-Mei
PMID: 21875481
Journal: World J Gastroenterol. 2012 Jan 14;18(2):126-35.
Title: Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin.
Author: Ye, Fei|Zhang, Gui-Hong|Guan, Bao-Xiang|Xu, Xiao-Chun
PMID: 22253518
Journal: Asian Pac J Cancer Prev. 2012;13(6):2527-32.
Title: Gene silencing of beta-catenin by RNAi inhibits proliferation of human esophageal cancer cells by inducing G0/G1 cell cycle arrest.
Author: Wang, Jin-Sheng|Ji, Ai-Fang|Wan, Hong-Jun|Lu, Ya-Li|Yang, Jian-Zhou|Ma, Li-Li|Wang, Yong-Jin|Wei, Wu
PMID: 22938416
Journal: Int J Mol Med. 2012 Dec;30(6):1403-9.
Title: Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer.
Author: Ma, Junfen|Zhao, Jimin|Lu, Jing|Jiang, Yanan|Yang, Hongyan|Li, Pei|Zhao, Mingyao|Liu, Kangdong|Dong, Ziming
PMID: 22992863
Journal: Oncol Rep. 2013 Jul;30(1):304-12.
Title: Raf kinase inhibitor protein inhibits esophageal cancer cell invasion through downregulation of matrix metalloproteinase expression.
Author: Zhao, Dongqiang|Ma, Junji|Shi, Junli|Cheng, Lijuan|Li, Fangfang|Jiang, Xiaoyu|Jiang, Huiqing
PMID: 23674108
Journal: PLoS One. 2013 Oct 9;8(10):e75254.
Title: Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression.
Author: Hsing, Chung-Hsi|Kwok, Franky Antonius|Cheng, Hung-Chi|Li, Chien-Feng|Chang, Ming-Shi
PMID: 24130695
Journal: In Vivo. 2013 Jul-Aug;27(4):473-84.
Title: Comparable molecular alterations in 4-nitroquinoline 1-oxide-induced oral and esophageal cancer in mice and in human esophageal cancer, associated with poor prognosis of patients.
Author: Yang, Zhengduo|Guan, Baoxiang|Men, Taoyan|Fujimoto, Junya|Xu, Xiaochun
PMID: 23812217
Journal: Mol Cancer Res. 2013 Sep;11(9):986-94.
Title: PTP1B contributes to calreticulin-induced metastatic phenotypes in esophageal squamous cell carcinoma.
Author: Wang, Xiao-Min|Shang, Li|Zhang, Yu|Hao, Jia-Jie|Shi, Feng|Luo, Wei|Zhang, Tong-Tong|Wang, Bo-Shi|Yang, Yang|Liu, Zhi-Hua|Zhan, Qi-Min|Wang, Ming-Rong
PMID: 23814025
Journal: J Mol Med (Berl). 2014 Nov;92(11):1209-23.
Title: ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways.
Author: Fichter, Christiane D|Gudernatsch, Verena|Przypadlo, Camilla M|Follo, Marie|Schmidt, Gudula|Werner, Martin|Lassmann, Silke
PMID: 25091467
Journal: Zhonghua Yi Xue Za Zhi. 2014 May 13;94(18):1416-8.
Title: [Expressions of Dab2 and ERK1 in esophageal carcinoma tissues and their clinical significance].
Author: Pang, Xia|Ma, Yuewei|Qu, Yunhui|Yang, Haijun|Gao, Dongling
PMID: 25142995
Journal: Sci Rep. 2014 Oct 31;4:6855.
Title: Antitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma.
Author: Zhang, Tiehong|Shen, Hongchang|Dong, Wei|Qu, Xiao|Liu, Qi|Du, Jiajun
PMID: 25358597
Journal: Int J Clin Exp Pathol. 2014 Oct 15;7(11):7663-71. eCollection 2014.
Title: Aquaporin-8 mediates human esophageal cancer Eca-109 cell migration via the EGFR-Erk1/2 pathway.
Author: Chang, Heng|Shi, Yong-Hua|Talaf, Tuo-Kan|Lin, Chen
PMID: 25550802
Journal: Int J Oncol. 2015 Jan;46(1):299-307.
Title: Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells.
Author: Liu, Yuting|Wang, Xiao|Wang, Ying|Zhang, Yi|Zheng, Kai|Yan, Haizhao|Zhang, Li|Chen, Wenbo|Wang, Xiaoyan|Liu, Qiuying|Wang, Shaoxiang|Wang, Yifei
PMID: 25333998
Journal: Cancer Lett. 2015 Apr 10;359(2):218-25.
Title: PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Author: Liu, Hongbing|Wu, Ying|Zhu, Suhua|Liang, Wenjun|Wang, Zhaofeng|Wang, Yunfen|Lv, Tangfeng|Yao, Yanwen|Yuan, Dongmei|Song, Yong
PMID: 25617799
Journal: Am J Transl Res. 2016 Aug 15;8(8):3398-408. eCollection 2016.
Title: Silencing of CXCR2 and CXCR7 protects against esophageal cancer.
Author: Wu, Kai|Cui, Lingling|Yang, Yang|Zhao, Jia|Zhu, Dengyan|Liu, Donglei|Zhang, Chunyang|Qi, Yu|Li, Xiangnan|Li, Weihao|Zhao, Song
PMID: 27648130
Journal: Eur Rev Med Pharmacol Sci. 2016 Nov;20(22):4688-4696.
Title: Effect and mechanism of PAR-2 on the proliferation of esophageal cancer cells.
Author: Quanjun, D|Qingyu, Z|Qiliang, Z|Liqun, X|Jinmei, C|Ziquan, L|Shike, H
PMID: 27906434
Journal: Asian Pac J Trop Med. 2016 Jan;9(1):86-90.
Title: Effect of recombinant human endostatin onradiotherapy for esophagus cancer.
Author: Liu, Gao-Feng|Chang, Hui|Li, Bao-Tian|Zhang, Yong|Li, Dan-Dan|Liu, Yan|Yang, Yang
PMID: 26851794
Journal: J Cell Biochem. 2017 Sep;118(9):2625-2634.
Title: Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro.
Author: Yang, Qing-Shan|Jiang, Li-Peng|He, Chun-Yan|Tong, Yu-Na|Liu, Yuan-Yuan
PMID: 27933650
Journal: Oncotarget. 2017 May 30;8(22):36149-36160.
Title: Stem cell autocrine CXCL12/CXCR4 stimulates invasion and metastasis of esophageal cancer.
Author: Wang, Xingwei|Cao, Yan|Zhang, Shirong|Chen, Zhihui|Fan, Ling|Shen, Xiaochun|Zhou, Shiwen|Chen, Dongfeng
PMID: 28193907
Journal: Oncol Res. 2017 May 24;25(5):663-671.
Title: PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells.
Author: Zhou, Fang|Wang, Shunchang|Wang, Jianjun
PMID: 28548040
Journal: Onco Targets Ther. 2018 Jan 4;11:211-220.
Title: RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression.
Author: Liu, Bowen|Wang, Cong|Chen, Pengxiang|Cheng, Bo|Cheng, Yufeng
PMID: 29379302
Journal: Oncol Lett. 2018 Mar;15(3):3937-3943.
Title: miR302a inhibits the proliferation of esophageal cancer cells through the MAPK and PI3K/Akt signaling pathways.
Author: Xia, Daokui|Tian, Shumei|Chen, Zhen|Qin, Wenchao|Liu, Quan
PMID: 29456742
Journal: Oncol Rep. 2018 Jun;39(6):2942-2950.
Title: Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the AktGSK3beta and MAPK/ERK signaling cascades.
Author: Wang, Xiaona|Zhu, Yanyan|Zhu, Lili|Chen, Xinhuan|Xu, Yanyan|Zhao, Yafei|Shao, Yingzhe|Li, Feng|Jiang, Yanan|Lu, Jing|Huang, Youtian|Chang, Xiaobin|Zhang, Juan|Li, Xiang|Liu, Kangdong|Zhao, Mingyao|Dong, Ziming|Zhao, Jimin
PMID: 29693162
Journal: Cancer Res. 2018 Sep 1;78(17):4957-4970.
Title: IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.
Author: Karakasheva, Tatiana A|Lin, Eric W|Tang, Qiaosi|Qiao, Edmund|Waldron, Todd J|Soni, Monica|Klein-Szanto, Andres J|Sahu, Varun|Basu, Devraj|Ohashi, Shinya|Baba, Kiichiro|Giaccone, Zachary T|Walker, Sarah R|Frank, David A|Wileyto, E Paul|Long, Qi|Dunagin, Ma
PMID: 29976575
Journal: Cell Death Dis. 2018 Jul 26;9(8):817.
Title: Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways.
Author: Cao, Jinlin|Lv, Wang|Wang, Luming|Xu, Jinming|Yuan, Ping|Huang, Sha|He, Zhehao|Hu, Jian
PMID: 30050135