Primary Site >> Biliary tract Cancer

Gene >> MAPK3

Journal: Hepatology. 1999 Nov;30(5):1128-33.
Title: Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line.
Author: Park, J|Tadlock, L|Gores, G J|Patel, T
PMID: 10534331
Journal: Gastroenterology. 2002 Apr;122(4):985-93.
Title: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.
Author: Yoon, Jung-Hwan|Higuchi, Hajime|Werneburg, Nathan W|Kaufmann, Scott H|Gores, Gregory J
PMID: 11910351
Journal: Cancer Res. 2005 Dec 15;65(24):11437-46.
Title: gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway.
Author: Fava, Giammarco|Marucci, Luca|Glaser, Shannon|Francis, Heather|De Morrow, Sharon|Benedetti, Antonio|Alvaro, Domenico|Venter, Julie|Meininger, Cynthia|Patel, Tushar|Taffetani, Silvia|Marzioni, Marco|Summers, Ryun|Reichenbach, Ramona|Alpini, Gianfranco
PMID: 16357152
Journal: J Cancer Res Clin Oncol. 2006 Dec;132(12):805-10. Epub 2006 Jun 23.
Title: Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma.
Author: Jinawath, Artit|Akiyama, Yoshimitsu|Yuasa, Yasuhito|Pairojkul, Chawalit
PMID: 16794828
Journal: Mol Cancer Ther. 2006 Jul;5(7):1895-903.
Title: Assessment of gefitinib- and CI-1040-mediated changes in epidermal growth factor receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration.
Author: Hidalgo, Manuel|Amador, Maria Luz|Jimeno, Antonio|Mezzadra, Heather|Patel, Pina|Chan, Audrey|Nielsen, Matthew E|Maitra, Anirban|Altiok, Soner
PMID: 16891476
Journal: Anticancer Drugs. 2006 Aug;17(7):783-95.
Title: Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib.
Author: Wiedmann, Marcus|Feisthammel, Jurgen|Bluthner, Thilo|Tannapfel, Andrea|Kamenz, Thomas|Kluge, Annett|Mossner, Joachim|Caca, Karel
PMID: 16926628
Journal: Am J Pathol. 2006 Sep;169(3):877-88.
Title: Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma.
Author: Alvaro, Domenico|Barbaro, Barbara|Franchitto, Antonio|Onori, Paolo|Glaser, Shannon S|Alpini, Gianfranco|Francis, Heather|Marucci, Luca|Sterpetti, Paola|Ginanni-Corradini, Stefano|Onetti Muda, Andrea|Dostal, David E|De Santis, Adriano|Attili, Adolfo F|Bene
PMID: 16936263
Journal: J Cancer Res Clin Oncol. 2007 Apr;133(4):271-8. Epub 2006 Nov 25.
Title: Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells.
Author: Jinawath, Artit|Akiyama, Yoshimitsu|Sripa, Banchob|Yuasa, Yasuhito
PMID: 17294242
Journal: World J Gastroenterol. 2007 Mar 14;13(10):1561-8.
Title: Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.
Author: Leelawat, Kawin|Leelawat, Surang|Narong, Siriluck|Hongeng, Suradej
PMID: 17461449
Journal: World J Gastroenterol. 2007 Dec 28;13(48):6470-7.
Title: AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma.
Author: Schmitz, K J|Lang, H|Wohlschlaeger, J|Sotiropoulos, G C|Reis, H|Schmid, K W|Baba, H A
PMID: 18161916
Journal: Hepatology. 2008 Apr;47(4):1178-90.
Title: A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines.
Author: Sirica, Alphonse E|Zhang, Zichen|Lai, Guan-Hua|Asano, Toru|Shen, Xue-Ning|Ward, Deanna J|Mahatme, Arvind|Dewitt, Jennifer L
PMID: 18081149
Journal: Oncol Rep. 2008 Oct;20(4):863-72.
Title: The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases.
Author: Matsumoto, Kazuya|Nagahara, Takakazu|Okano, Jun-Ichi|Murawaki, Yoshikazu
PMID: 18813828
Journal: J Exp Clin Cancer Res. 2009 May 18;28:65.
Title: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
Author: Li, Qinglong|Yang, Zhulin
PMID: 19445727
Journal: Mol Cancer Res. 2009 Oct;7(10):1704-13.
Title: H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.
Author: Francis, Heather|Onori, Paolo|Gaudio, Eugenio|Franchitto, Antonio|DeMorrow, Sharon|Venter, Julie|Kopriva, Shelley|Carpino, Guido|Mancinelli, Romina|White, Mellanie|Meng, Fanyin|Vetuschi, Antonella|Sferra, Roberta|Alpini, Gianfranco
PMID: 19825989
Journal: World J Gastroenterol. 2010 Feb 14;16(6):713-22.
Title: Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion.
Author: Menakongka, Apaporn|Suthiphongchai, Tuangporn
PMID: 20135719
Journal: World J Gastroenterol. 2010 Aug 28;16(32):4047-54.
Title: High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K.
Author: Treekitkarnmongkol, Warapen|Suthiphongchai, Tuangporn
PMID: 20731018
Journal: Biochem Biophys Res Commun. 2011 Feb 18;405(3):333-7.
Title: Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2.
Author: Yoon, Hyunho|Min, Jeong-Ki|Lee, Jung Whoi|Kim, Dae-Ghon|Hong, Hyo Jeong
PMID: 21130731
Journal: Mol Cancer. 2011 Aug 26;10:102.
Title: Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma.
Author: Obchoei, Sumalee|Weakley, Sarah M|Wongkham, Sopit|Wongkham, Chaisiri|Sawanyawisuth, Kanlayanee|Yao, Qizhi|Chen, Changyi
PMID: 21871105
Journal: Hepatology. 2012 Jan;55(1):121-31.
Title: Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss.
Author: Morris, Shelli M|Baek, Ji Yeon|Koszarek, Amanda|Kanngurn, Samornmas|Knoblaugh, Sue E|Grady, William M
PMID: 21898503
Journal: Gut. 2012 Feb;61(2):268-77.
Title: Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism.
Author: Frampton, Gabriel|Invernizzi, Pietro|Bernuzzi, Francesca|Pae, Hae Yong|Quinn, Matthew|Horvat, Darijana|Galindo, Cheryl|Huang, Li|McMillin, Matthew|Cooper, Brandon|Rimassa, Lorenza|DeMorrow, Sharon
PMID: 22068162
Journal: Hepatology. 2012 Dec;56(6):2268-76.
Title: A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver.
Author: Liu, Wangta|Chen, Jim-Ray|Hsu, Chih-Hao|Li, Yen-Hsing|Chen, Yi-Meng|Lin, Chien-Yuan|Huang, Shin-Jie|Chang, Zen-Kuei|Chen, Yen-Chun|Lin, Chi-Hsueh|Gong, Hong-Yi|Lin, Ching-Chun|Kawakami, Koichi|Wu, Jen-Leih
PMID: 22729936
Journal: ISRN Hepatol. 2013 Nov 17;2013:601071.
Title: Protective Effects of Guava Pulp on Cholestatic Liver Injury.
Author: Peng, Jian|Yue, Chunyan|Qiu, Kai|Chen, Jie|Aller, Maria-Angeles|Ko, Kwang Suk|Yang, Heping
PMID: 27335829
Journal: Anticancer Res. 2013 May;33(5):1861-6.
Title: Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells.
Author: Ono, Misaki|Higuchi, Takako|Takeshima, Mikako|Chen, Chen|Nakano, Shuji
PMID: 23645731
Journal: Oncol Lett. 2013 Nov;6(5):1439-1446.
Title: CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2.
Author: Leelawat, Kawin|Keeratichamroen, Siriporn|Leelawat, Surang|Tohtong, Rutaiwan
PMID: 24179538
Journal: Dig Dis Sci. 2013 Jun;58(6):1627-35.
Title: A high level of integrin alpha6 expression in human intrahepatic cholangiocarcinoma cells is associated with a migratory and invasive phenotype.
Author: Ding, Yan-bing|Deng, Bin|Huang, You-sheng|Xiao, Wei-ming|Wu, Jian|Zhang, Yan-qing|Wang, Yuan-zhi|Wu, Da-cheng|Lu, Guo-tao|Wu, Ke-yan
PMID: 23306848
Journal: Tumour Biol. 2013 Dec;34(6):3519-28.
Title: Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment.
Author: Dokduang, Hasaya|Juntana, Sirinun|Techasen, Anchalee|Namwat, Nisana|Yongvanit, Puangrat|Khuntikeo, Narong|Riggins, Gregory J|Loilome, Watcharin
PMID: 23812726
Journal: Carcinogenesis. 2014 Mar;35(3):597-605.
Title: CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils.
Author: Zhou, Shao-Lai|Dai, Zhi|Zhou, Zheng-Jun|Chen, Qing|Wang, Zheng|Xiao, Yong-Sheng|Hu, Zhi-Qiang|Huang, Xiao-Yong|Yang, Guo-Huan|Shi, Ying-Hong|Qiu, Shuang-Jian|Fan, Jia|Zhou, Jian
PMID: 24293410
Journal: Hepatology. 2014 Sep;60(3):908-18.
Title: Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2.
Author: Liu, Runping|Zhao, Renping|Zhou, Xiqiao|Liang, Xiuyin|Campbell, Deanna J W|Zhang, Xiaoxuan|Zhang, Luyong|Shi, Ruihua|Wang, Guangji|Pandak, William M|Sirica, Alphonse E|Hylemon, Phillip B|Zhou, Huiping
PMID: 24700501
Journal: Cell Signal. 2014 Aug;26(8):1668-79.
Title: Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration.
Author: Janpipatkul, Keatdamrong|Suksen, Kanoknetr|Borwornpinyo, Suparerk|Jearawiriyapaisarn, Natee|Hongeng, Suradej|Piyachaturawat, Pawinee|Chairoungdua, Arthit
PMID: 24726839
Journal: Int J Oncol. 2015;46(6):2317-26.
Title: Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway.
Author: Amonyingcharoen, Sumet|Suriyo, Tawit|Thiantanawat, Apinya|Watcharasit, Piyajit|Satayavivad, Jutamaad
PMID: 25815516
Journal: BMC Cancer. 2015 Nov 16;15:903.
Title: Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44nu is an indicator for recurrence in advanced cancer.
Author: Wu, Cheng-Lin|Chao, Ying-Jui|Yang, Ta-Ming|Chen, Yi-Ling|Chang, Kung-Chao|Hsu, Hui-Ping|Shan, Yan-Shen|Lai, Ming-Derg
PMID: 26572077
Journal: BMC Cancer. 2016 Mar 19;16:240.
Title: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway.
Author: Hong, HaiJie|Jiang, Lei|Lin, YanFei|He, CaiLong|Zhu, GuangWei|Du, Qiang|Wang, XiaoQian|She, FeiFei|Chen, YanLing
PMID: 26992854
Journal: Mol Med Rep. 2016 May;13(5):4461-8.
Title: Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis.
Author: Jia, Jianguang|Qin, Yiyu|Zhang, Ligong|Guo, Chenxu|Wang, Yaguo|Yue, Xicheng|Qian, Jun
PMID: 27035431
Journal: J Exp Clin Cancer Res. 2016 Mar 24;35:51.
Title: CCR7 mediates the TNF-alpha-induced lymphatic metastasis of gallbladder cancer through the "ERK1/2 - AP-1" and "JNK - AP-1" pathways.
Author: Hong, HaiJie|He, CaiLong|Zhu, SiYuan|Zhang, YanHui|Wang, XiaoQian|She, FeiFei|Chen, YanLing
PMID: 27009073
Journal: Zhonghua Wai Ke Za Zhi. 2016 Mar 1;54(3):222-7.
Title: [Artemisinin inhibits proliferation of gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis].
Author: Jia, J G|Zhang, L G|Guo, C X|Wang, Y G|Chen, B L|Wang, Y M|Qian, J
PMID: 26932893
Journal: Gut Liver. 2016 Mar;10(2):310-7.
Title: Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells.
Author: Lee, Jin|Hong, Eun Mi|Jang, Ju Ah|Park, Se Woo|Koh, Dong Hee|Choi, Min Ho|Jang, Hyun Joo|Kae, Sea Hyub
PMID: 26470769
Journal: Gut. 2016 Mar;65(3):487-501.
Title: TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.
Author: Reich, Maria|Deutschmann, Kathleen|Sommerfeld, Annika|Klindt, Caroline|Kluge, Stefanie|Kubitz, Ralf|Ullmer, Christoph|Knoefel, Wolfram T|Herebian, Diran|Mayatepek, Ertan|Haussinger, Dieter|Keitel, Verena
PMID: 26420419
Journal: Hepatology. 2017 Jun;65(6):2005-2018.
Title: The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.
Author: Wang, Yongqing|Aoki, Hiroaki|Yang, Jing|Peng, Kesong|Liu, Runping|Li, Xiaojiaoyang|Qiang, Xiaoyan|Sun, Lixin|Gurley, Emily C|Lai, Guanhua|Zhang, Luyong|Liang, Guang|Nagahashi, Masayuki|Takabe, Kazuaki|Pandak, William M|Hylemon, Phillip B|Zhou, Huiping
PMID: 28120434
Journal: Pathol Res Pract. 2017 May;213(5):476-482.
Title: The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer.
Author: Buchegger, Kurt|Silva, Ramon|Lopez, Jaime|Ili, Carmen|Araya, Juan Carlos|Leal, Pamela|Brebi, Priscilla|Riquelme, Ismael|Roa, Juan Carlos
PMID: 28285962
Journal: Oncol Lett. 2017 May;13(5):3850-3858.
Title: Combination of celecoxib and PD184161 exerts synergistic inhibitory effects on gallbladder cancer cell proliferation.
Author: Deng, Min|Qin, Yiyu|Chen, Xiaodong|Li, Dapeng|Wang, Qiangwu|Zheng, Hailun|Gu, Lin|Deng, Chaojing|Xue, Yongju|Zhu, Danyu|Wang, Qizhi|Wang, Jianchao
PMID: 28521485
Journal: Cancer Lett. 2017 Sep 10;403:66-73.
Title: Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer.
Author: Takasawa, Kumi|Takasawa, Akira|Osanai, Makoto|Aoyama, Tomoyuki|Ono, Yusuke|Kono, Tsuyoshi|Hirohashi, Yoshihiko|Murata, Masaki|Sawada, Norimasa
PMID: 28624624
Journal: Cancer Cell Int. 2017 Sep 26;17:85.
Title: Blocking ERK1/2 signaling impairs TGF-beta1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells.
Author: Sritananuwat, Phaijit|Sueangoen, Natthaporn|Thummarati, Parichut|Islam, Kittiya|Suthiphongchai, Tuangporn
PMID: 28959141
Journal: Cell Death Dis. 2017 Dec 13;8(12):3205.
Title: Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma.
Author: Xie, Nan|Cai, Jia-Bin|Zhang, Lu|Zhang, Peng-Fei|Shen, Ying-Hao|Yang, Xuan|Lu, Jia-Cheng|Gao, Dong-Mei|Kang, Qiang|Liu, Li-Xin|Zhang, Chi|Huang, Xiao-Yong|Zou, Hao|Zhang, Xin-Yu|Song, Zheng-Ji|Sun, Hai-Xiang|Fu, Bi-Mang|Ke, Ai-Wu|Shi, Guo-Ming
PMID: 29235470
Journal: Biochem Biophys Res Commun. 2018 May 15;499(3):433-440.
Title: Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.
Author: Chen, Jian|Song, Wenfeng|Du, Yehui|Li, Zequn|Xuan, Zefeng|Zhao, Long|Chen, Jun|Zhao, Yongchao|Tuo, Biguang|Zheng, Shusen|Song, Penghong
PMID: 29574153
Journal: Cell Death Dis. 2018 Oct 10;9(10):1036.
Title: BAP1 acts as a tumor suppressor in intrahepatic cholangiocarcinoma by modulating the ERK1/2 and JNK/c-Jun pathways.
Author: Chen, Xu-Xiao|Yin, Yue|Cheng, Jian-Wen|Huang, Ao|Hu, Bo|Zhang, Xin|Sun, Yun-Fan|Wang, Jian|Wang, Yu-Peng|Ji, Yuan|Qiu, Shuang-Jian|Fan, Jia|Zhou, Jian|Yang, Xin-Rong
PMID: 30305612