Primary Site >> Biliary tract Cancer
Gene >> MAPK3
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Ref: Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line. PMID: 10534331 |
Ref: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. PMID: 11910351 |
Ref: gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. PMID: 16357152 |
Ref: Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma. PMID: 16794828 Ref: Assessment of gefitinib- and CI-1040-mediated changes in epidermal growth factor receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration. PMID: 16891476 Ref: Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib. PMID: 16926628 Ref: Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. PMID: 16936263 |
Ref: Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. PMID: 17294242 Ref: Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. PMID: 17461449 Ref: AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma. PMID: 18161916 |
Ref: A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. PMID: 18081149 Ref: The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases. PMID: 18813828 |
Ref: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. PMID: 19445727 Ref: H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. PMID: 19825989 |
Ref: Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion. PMID: 20135719 Ref: High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K. PMID: 20731018 |
Ref: Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. PMID: 21130731 Ref: Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. PMID: 21871105 |
Ref: Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss. PMID: 21898503 Ref: Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism. PMID: 22068162 Ref: A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. PMID: 22729936 |
Ref: A high level of integrin alpha6 expression in human intrahepatic cholangiocarcinoma cells is associated with a migratory and invasive phenotype. PMID: 23306848 Ref: Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells. PMID: 23645731 Ref: Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment. PMID: 23812726 Ref: CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2. PMID: 24179538 Ref: Protective Effects of Guava Pulp on Cholestatic Liver Injury. PMID: 27335829 |
Ref: CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils. PMID: 24293410 Ref: Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. PMID: 24700501 Ref: Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration. PMID: 24726839 |
Ref: Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway. PMID: 25815516 Ref: Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44nu is an indicator for recurrence in advanced cancer. PMID: 26572077 |
Ref: TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro. PMID: 26420419 Ref: Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells. PMID: 26470769 Ref: [Artemisinin inhibits proliferation of gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis]. PMID: 26932893 Ref: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway. PMID: 26992854 Ref: CCR7 mediates the TNF-alpha-induced lymphatic metastasis of gallbladder cancer through the "ERK1/2 - AP-1" and "JNK - AP-1" pathways. PMID: 27009073 Ref: Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis. PMID: 27035431 |
Ref: The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. PMID: 28120434 Ref: The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer. PMID: 28285962 Ref: Combination of celecoxib and PD184161 exerts synergistic inhibitory effects on gallbladder cancer cell proliferation. PMID: 28521485 Ref: Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer. PMID: 28624624 Ref: Blocking ERK1/2 signaling impairs TGF-beta1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells. PMID: 28959141 Ref: Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma. PMID: 29235470 |
Ref: Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation. PMID: 29574153 Ref: BAP1 acts as a tumor suppressor in intrahepatic cholangiocarcinoma by modulating the ERK1/2 and JNK/c-Jun pathways. PMID: 30305612 |