Primary Site >> Biliary tract Cancer

Gene >> MAPK1

Journal: Hepatology. 1999 Nov;30(5):1128-33.
Title: Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line.
Author: Park, J|Tadlock, L|Gores, G J|Patel, T
PMID: 10534331
Journal: Hepatology. 2001 Jan;33(1):43-51.
Title: Involvement of p38 mitogen-activated protein kinase signaling in transformed growth of a cholangiocarcinoma cell line.
Author: Tadlock, L|Patel, T
PMID: 11124819
Journal: Hepatology. 2002 Aug;36(2):363-73.
Title: Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
Author: Wu, Tong|Han, Chang|Lunz, John G 3rd|Michalopoulos, George|Shelhamer, James H|Demetris, A Jake
PMID: 12143044
Journal: Gastroenterology. 2002 Apr;122(4):985-93.
Title: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.
Author: Yoon, Jung-Hwan|Higuchi, Hajime|Werneburg, Nathan W|Kaufmann, Scott H|Gores, Gregory J
PMID: 11910351
Journal: Gut. 2003 May;52(5):706-12.
Title: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma.
Author: Tannapfel, A|Sommerer, F|Benicke, M|Katalinic, A|Uhlmann, D|Witzigmann, H|Hauss, J|Wittekind, C
PMID: 12692057
Journal: Hepatology. 2003 May;37(5):1122-9.
Title: Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma.
Author: Tanaka, Shinji|Sugimachi, Keishi|Kameyama, Toshifumi|Maehara, Shin-Ichiro|Shirabe, Ken|Shimada, Mitsuo|Wands, Jack R|Maehara, Yoshihiko
PMID: 12717393
Journal: Hepatology. 2004 Mar;39(3):732-8.
Title: Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis.
Author: Yoon, Jung-Hwan|Canbay, Ali E|Werneburg, Nathan W|Lee, Sum P|Gores, Gregory J
PMID: 14999691
Journal: J Clin Invest. 2006 Jul;116(7):1843-52. Epub 2006 Jun 8.
Title: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Author: Xu, Xiaoling|Kobayashi, Shogo|Qiao, Wenhui|Li, Cuiling|Xiao, Cuiying|Radaeva, Svetlana|Stiles, Bangyan|Wang, Rui-Hong|Ohara, Nobuya|Yoshino, Tadashi|LeRoith, Derek|Torbenson, Michael S|Gores, Gregory J|Wu, Hong|Gao, Bin|Deng, Chu-Xia
PMID: 16767220
Journal: J Cancer Res Clin Oncol. 2006 Dec;132(12):805-10. Epub 2006 Jun 23.
Title: Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma.
Author: Jinawath, Artit|Akiyama, Yoshimitsu|Yuasa, Yasuhito|Pairojkul, Chawalit
PMID: 16794828
Journal: Mol Cancer Ther. 2006 Jul;5(7):1895-903.
Title: Assessment of gefitinib- and CI-1040-mediated changes in epidermal growth factor receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration.
Author: Hidalgo, Manuel|Amador, Maria Luz|Jimeno, Antonio|Mezzadra, Heather|Patel, Pina|Chan, Audrey|Nielsen, Matthew E|Maitra, Anirban|Altiok, Soner
PMID: 16891476
Journal: Mol Cell Biochem. 2007 Nov;305(1-2):19-26. Epub 2007 Jun 6.
Title: Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling.
Author: Zhang, Li|Jiang, Li|Sun, Qiuyan|Peng, Tao|Lou, Kexin|Liu, Ningbo|Leng, Jing
PMID: 17551669
Journal: Hepatogastroenterology. 2007 Jul-Aug;54(77):1339-44.
Title: Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma.
Author: Ailawadhi, Sikander|Nagase, Hiroki|Khoury, Thaer|Yu, Jihnhee|Tan, Dongfeng|Black, Jennifer|Brattain, Michael|Javle, Milind
PMID: 17708250
Journal: World J Gastroenterol. 2007 Dec 28;13(48):6470-7.
Title: AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma.
Author: Schmitz, K J|Lang, H|Wohlschlaeger, J|Sotiropoulos, G C|Reis, H|Schmid, K W|Baba, H A
PMID: 18161916
Journal: Oncol Rep. 2008 Oct;20(4):863-72.
Title: The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases.
Author: Matsumoto, Kazuya|Nagahara, Takakazu|Okano, Jun-Ichi|Murawaki, Yoshikazu
PMID: 18813828
Journal: Mol Cancer Res. 2009 Oct;7(10):1704-13.
Title: H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.
Author: Francis, Heather|Onori, Paolo|Gaudio, Eugenio|Franchitto, Antonio|DeMorrow, Sharon|Venter, Julie|Kopriva, Shelley|Carpino, Guido|Mancinelli, Romina|White, Mellanie|Meng, Fanyin|Vetuschi, Antonella|Sferra, Roberta|Alpini, Gianfranco
PMID: 19825989
Journal: J Exp Clin Cancer Res. 2009 May 18;28:65.
Title: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
Author: Li, Qinglong|Yang, Zhulin
PMID: 19445727
Journal: Dig Dis Sci. 2010 Oct;55(10):2844-52.
Title: The role of MAPK-ERK pathway in 67-kDa laminin receptor-induced FasL expression in human cholangiocarcinoma cells.
Author: Duan, Shi-Gang|Cheng, Long|Li, Da-Jiang|Zhu, Jin|Xiong, Yan|Li, Xiao-Wu|Wang, Shu-Guang
PMID: 20101459
Journal: World J Gastroenterol. 2010 Feb 14;16(6):713-22.
Title: Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion.
Author: Menakongka, Apaporn|Suthiphongchai, Tuangporn
PMID: 20135719
Journal: Hepatogastroenterology. 2010 May-Jun;57(99-100):426-9.
Title: Effective treatment of advanced cholangiocarcinoma by hepatic arterial infusion chemotherapy combination with sorafenib: one case report from China.
Author: Qun, Wang|Tao, Yin
PMID: 20698202
Journal: J Hepatobiliary Pancreat Sci. 2011 Mar;18(2):147-53.
Title: Protease-activated receptor-2 regulates cyclooxygenase-2 expression in human bile duct cancer via the pathways of mitogen-activated protein kinases and nuclear factor kappa B.
Author: Eguchi, Hidetoshi|Iwaki, Kentaro|Shibata, Kohei|Ogawa, Tadashi|Ohta, Masayuki|Kitano, Seigo
PMID: 20740367
Journal: J Gastroenterol. 2011 May;46(5):664-75.
Title: Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
Author: Namwat, N|Puetkasichonpasutha, J|Loilome, W|Yongvanit, P|Techasen, A|Puapairoj, A|Sripa, B|Tassaneeyakul, W|Khuntikeo, N|Wongkham, S
PMID: 21076843
Journal: Biochem Biophys Res Commun. 2011 Feb 18;405(3):333-7.
Title: Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2.
Author: Yoon, Hyunho|Min, Jeong-Ki|Lee, Jung Whoi|Kim, Dae-Ghon|Hong, Hyo Jeong
PMID: 21130731
Journal: Invest New Drugs. 2012 Aug;30(4):1646-51.
Title: SWOG 0514: a phase II study of sorafenib in patients with unresectable or metastatic gallbladder carcinoma and cholangiocarcinoma.
Author: El-Khoueiry, Anthony B|Rankin, Cathryn J|Ben-Josef, Edgar|Lenz, Heinz-Josef|Gold, Philip J|Hamilton, R Darryl|Govindarajan, Rangaswamy|Eng, Cathy|Blanke, Charles D
PMID: 21748296
Journal: Hepatology. 2012 Dec;56(6):2268-76.
Title: A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver.
Author: Liu, Wangta|Chen, Jim-Ray|Hsu, Chih-Hao|Li, Yen-Hsing|Chen, Yi-Meng|Lin, Chien-Yuan|Huang, Shin-Jie|Chang, Zen-Kuei|Chen, Yen-Chun|Lin, Chi-Hsueh|Gong, Hong-Yi|Lin, Ching-Chun|Kawakami, Koichi|Wu, Jen-Leih
PMID: 22729936
Journal: Anticancer Res. 2012 Dec;32(12):5251-62.
Title: Gefitinib and gemcitabine coordinately inhibited the proliferation of cholangiocarcinoma cells.
Author: Nakajima, Yoshimi|Takagi, Hitoshi|Kakizaki, Satoru|Horiguchi, Norio|Sato, Ken|Sunaga, Noriaki|Mori, Masatomo
PMID: 23225424
Journal: ISRN Hepatol. 2013 Nov 17;2013:601071.
Title: Protective Effects of Guava Pulp on Cholestatic Liver Injury.
Author: Peng, Jian|Yue, Chunyan|Qiu, Kai|Chen, Jie|Aller, Maria-Angeles|Ko, Kwang Suk|Yang, Heping
PMID: 27335829
Journal: Oncol Lett. 2013 Nov;6(5):1439-1446.
Title: CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2.
Author: Leelawat, Kawin|Keeratichamroen, Siriporn|Leelawat, Surang|Tohtong, Rutaiwan
PMID: 24179538
Journal: Hepatology. 2013 Jun;57(6):2248-60.
Title: Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis.
Author: Cui, Xiang-Dan|Lee, Mi-Jin|Kim, Jong-Hyun|Hao, Pei-Pei|Liu, Lan|Yu, Goung-Ran|Kim, Dae-Ghon
PMID: 23315987
Journal: Clin Cancer Res. 2013 Jan 1;19(1):118-27.
Title: Sequence dependence of MEK inhibitor AZD6244 combined with gemcitabine for the treatment of biliary cancer.
Author: Xu, Junyao|Knox, Jennifer J|Ibrahimov, Emin|Chen, Eric|Serra, Stefano|Tsao, Ming|Cao, Pinjiang|Vines, Douglass|Green, David E|Metran-Nascente, Cristiane|McNamara, Mairead G|Hedley, David W
PMID: 23091117
Journal: Int J Oncol. 2013 Feb;42(2):690-8.
Title: Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma.
Author: Yang, Wei|Wang, Xiaoyuan|Zheng, Wei|Li, Kedong|Liu, Haofeng|Sun, Yueming
PMID: 23254774
Journal: Biochimie. 2014 Jun;101:183-91.
Title: Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-kappaB pathway.
Author: Li, Wenjiao|Li, Ming|Su, Xinhui|Qin, Liping|Miao, Mengmeng|Yu, Chundong|Shen, Yuemao|Luo, Qi|Chen, Qiang
PMID: 24486723
Journal: Cancer Biol Ther. 2014 Jun 1;15(6):806-14.
Title: MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway.
Author: Wu, Xiang-Song|Wang, Xu-An|Wu, Wen-Guang|Hu, Yun-Ping|Li, Mao-Lan|Ding, Qian|Weng, Hao|Shu, Yi-Jun|Liu, Tian-Yu|Jiang, Lin|Cao, Yang|Bao, Run-Fa|Mu, Jia-Sheng|Tan, Zhu-Jun|Tao, Feng|Liu, Ying-Bin
PMID: 24658096
Journal: Hepatology. 2014 Sep;60(3):908-18.
Title: Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2.
Author: Liu, Runping|Zhao, Renping|Zhou, Xiqiao|Liang, Xiuyin|Campbell, Deanna J W|Zhang, Xiaoxuan|Zhang, Luyong|Shi, Ruihua|Wang, Guangji|Pandak, William M|Sirica, Alphonse E|Hylemon, Phillip B|Zhou, Huiping
PMID: 24700501
Journal: Tumour Biol. 2015 Mar;36(3):1781-9.
Title: Up-regulation of 14-3-3zeta expression in intrahepatic cholangiocarcinoma and its clinical implications.
Author: Zhang, Chi|Liu, Li-Xin|Dong, Zhao-Ru|Shi, Guo-Ming|Cai, Jia-Bin|Zhang, Peng-Fei|Ke, Ai-Wu|Yu, Jing-Xian|Zhou, Jian|Fan, Jia
PMID: 25391422
Journal: Tumour Biol. 2015 Jul;36(7):5171-7.
Title: Loss of angiotensin-converting enzyme 2 promotes growth of gallbladder cancer.
Author: Zong, Huajie|Yin, Baobing|Zhou, Huading|Cai, Duan|Ma, Baojin|Xiang, Yang
PMID: 25663464
Journal: Int J Oncol. 2015;46(6):2317-26.
Title: Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway.
Author: Amonyingcharoen, Sumet|Suriyo, Tawit|Thiantanawat, Apinya|Watcharasit, Piyajit|Satayavivad, Jutamaad
PMID: 25815516
Journal: BMC Cancer. 2015 Nov 16;15:903.
Title: Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44nu is an indicator for recurrence in advanced cancer.
Author: Wu, Cheng-Lin|Chao, Ying-Jui|Yang, Ta-Ming|Chen, Yi-Ling|Chang, Kung-Chao|Hsu, Hui-Ping|Shan, Yan-Shen|Lai, Ming-Derg
PMID: 26572077
Journal: BMC Cancer. 2016 Mar 19;16:240.
Title: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway.
Author: Hong, HaiJie|Jiang, Lei|Lin, YanFei|He, CaiLong|Zhu, GuangWei|Du, Qiang|Wang, XiaoQian|She, FeiFei|Chen, YanLing
PMID: 26992854
Journal: Oncotarget. 2016 Nov 8;7(45):72833-72844.
Title: Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway.
Author: Shen, Sheng|Liu, Han|Wang, Yueqi|Wang, Jiwen|Ni, Xiaolin|Ai, Zhilong|Pan, Hongtao|Liu, Houbao|Shao, Yebo
PMID: 27637083
Journal: PLoS One. 2016 Sep 14;11(9):e0162594.
Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation.
Author: Hall, Terence G|Yu, Yi|Eathiraj, Sudharshan|Wang, Yunxia|Savage, Ronald E|Lapierre, Jean-Marc|Schwartz, Brian|Abbadessa, Giovanni
PMID: 27627808
Journal: J Exp Clin Cancer Res. 2016 Apr 16;35:68.
Title: Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer.
Author: Cao, Yang|Liang, Haibin|Zhang, Fei|Luan, Zhou|Zhao, Shuai|Wang, Xu-An|Liu, Shibo|Bao, Runfa|Shu, Yijun|Ma, Qiang|Zhu, Jian|Liu, Yingbin
PMID: 27084680
Journal: Mol Med Rep. 2016 May;13(5):4461-8.
Title: Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis.
Author: Jia, Jianguang|Qin, Yiyu|Zhang, Ligong|Guo, Chenxu|Wang, Yaguo|Yue, Xicheng|Qian, Jun
PMID: 27035431
Journal: World J Gastroenterol. 2016 Feb 14;22(6):2071-80.
Title: Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.
Author: Ding, Ning|Che, Li|Li, Xiao-Lei|Liu, Yan|Jiang, Li-Jie|Fan, Biao|Tao, Jun-Yan|Chen, Xin|Ji, Jia-Fu
PMID: 26877611
Journal: Tumour Biol. 2016 Jul;37(7):9451-63.
Title: YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma.
Author: Thongsom, Sunisa|Chaocharoen, Wethaka|Silsirivanit, Atit|Wongkham, Sopit|Sripa, Banchob|Choe, Han|Suginta, Wipa|Talabnin, Chutima
PMID: 26781979
Journal: Gut Liver. 2016 Mar;10(2):310-7.
Title: Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells.
Author: Lee, Jin|Hong, Eun Mi|Jang, Ju Ah|Park, Se Woo|Koh, Dong Hee|Choi, Min Ho|Jang, Hyun Joo|Kae, Sea Hyub
PMID: 26470769
Journal: Gut. 2016 Mar;65(3):487-501.
Title: TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.
Author: Reich, Maria|Deutschmann, Kathleen|Sommerfeld, Annika|Klindt, Caroline|Kluge, Stefanie|Kubitz, Ralf|Ullmer, Christoph|Knoefel, Wolfram T|Herebian, Diran|Mayatepek, Ertan|Haussinger, Dieter|Keitel, Verena
PMID: 26420419
Journal: Oncotarget. 2017 Feb 28;8(9):15775-15788.
Title: Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.
Author: Wang, Yueqi|Gao, Zhihui|Zhang, Dexiang|Bo, Xiaobo|Wang, Yaojie|Wang, Jiwen|Shen, Sheng|Liu, Han|Suo, Tao|Pan, Hongtao|Ai, Zhilong|Liu, Houbao
PMID: 28178656
Journal: Pathol Res Pract. 2017 May;213(5):476-482.
Title: The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer.
Author: Buchegger, Kurt|Silva, Ramon|Lopez, Jaime|Ili, Carmen|Araya, Juan Carlos|Leal, Pamela|Brebi, Priscilla|Riquelme, Ismael|Roa, Juan Carlos
PMID: 28285962
Journal: Cancer Lett. 2017 Sep 10;403:66-73.
Title: Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer.
Author: Takasawa, Kumi|Takasawa, Akira|Osanai, Makoto|Aoyama, Tomoyuki|Ono, Yusuke|Kono, Tsuyoshi|Hirohashi, Yoshihiko|Murata, Masaki|Sawada, Norimasa
PMID: 28624624
Journal: J Transl Med. 2017 Nov 25;15(1):238.
Title: Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling.
Author: Tang, Jing|Liao, Yan|He, Shuying|Shi, Jie|Peng, Liang|Xu, Xiaoping|Xie, Fang|Diao, Na|Huang, Jinlan|Xie, Qian|Lin, Chuang|Luo, Xiaoying|Liao, Kaili|Ma, Juanjuan|Li, Jingyi|Zhou, Daichao|Li, Zhijun|Xu, Jun|Zhong, Chao|Wang, Guozhen|Bai, Lan
PMID: 29178939
Journal: Cytotechnology. 2018 Feb;70(1):439-448.
Title: Metformin synergistically enhances antitumor activity of cisplatin in gallbladder cancer via the PI3K/AKT/ERK pathway.
Author: Bi, Tingting|Zhu, Ao|Yang, Xufeng|Qiao, Huiying|Tang, Jinmei|Liu, Yan|Lv, Rong
PMID: 29110119
Journal: Cell Death Dis. 2018 Jan 18;9(2):31.
Title: Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.
Author: Dong, Mingjie|Liu, Xianqiong|Evert, Katja|Utpatel, Kirsten|Peters, Michele|Zhang, Shanshan|Xu, Zhong|Che, Li|Cigliano, Antonio|Ribback, Silvia|Dombrowski, Frank|Cossu, Antonio|Gordan, John|Calvisi, Diego F|Evert, Matthias|Liu, Yan|Chen, Xin
PMID: 29348467
Journal: Cell Death Dis. 2018 Feb 7;9(2):179.
Title: Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of beta-Catenin.
Author: Zheng, Yan|Zhou, Chuang|Yu, Xin-Xin|Wu, Chao|Jia, Hu-Liang|Gao, Xiao-Mei|Yang, Ji-Meng|Wang, Chao-Qun|Luo, Qin|Zhu, Ying|Zhang, Yu|Wei, Jin-Wang|Sheng, Yuan-Yuan|Dong, Qiong-Zhu|Qin, Lun-Xiu
PMID: 29415992
Journal: Biochem Biophys Res Commun. 2018 May 15;499(3):433-440.
Title: Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.
Author: Chen, Jian|Song, Wenfeng|Du, Yehui|Li, Zequn|Xuan, Zefeng|Zhao, Long|Chen, Jun|Zhao, Yongchao|Tuo, Biguang|Zheng, Shusen|Song, Penghong
PMID: 29574153
Journal: Int J Mol Sci. 2018 Oct 12;19(10). pii: ijms19103141.
Title: MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.
Author: Miao, Wenyu|Sakai, Katsuya|Imamura, Ryu|Ito, Kenichiro|Suga, Hiroaki|Sakuma, Tetsushi|Yamamoto, Takashi|Matsumoto, Kunio
PMID: 30322054