Primary Site >> Biliary tract Cancer

Gene >> MAPK1

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Ref: Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line.
PMID: 10534331
 Ref: Involvement of p38 mitogen-activated protein kinase signaling in transformed growth of a cholangiocarcinoma cell line.
PMID: 11124819
 Ref: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.
PMID: 11910351
Ref: Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
PMID: 12143044
 Ref: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma.
PMID: 12692057
Ref: Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma.
PMID: 12717393
 Ref: Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis.
PMID: 14999691
 Ref: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
PMID: 16767220
Ref: Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma.
PMID: 16794828
Ref: Assessment of gefitinib- and CI-1040-mediated changes in epidermal growth factor receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration.
PMID: 16891476
 Ref: Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling.
PMID: 17551669
Ref: Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma.
PMID: 17708250
Ref: AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma.
PMID: 18161916
 Ref: The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases.
PMID: 18813828
 Ref: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
PMID: 19445727
Ref: H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.
PMID: 19825989
 Ref: The role of MAPK-ERK pathway in 67-kDa laminin receptor-induced FasL expression in human cholangiocarcinoma cells.
PMID: 20101459
Ref: Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion.
PMID: 20135719
Ref: Effective treatment of advanced cholangiocarcinoma by hepatic arterial infusion chemotherapy combination with sorafenib: one case report from China.
PMID: 20698202
 Ref: Protease-activated receptor-2 regulates cyclooxygenase-2 expression in human bile duct cancer via the pathways of mitogen-activated protein kinases and nuclear factor kappa B.
PMID: 20740367
Ref: Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
PMID: 21076843
Ref: Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2.
PMID: 21130731
 Ref: SWOG 0514: a phase II study of sorafenib in patients with unresectable or metastatic gallbladder carcinoma and cholangiocarcinoma.
PMID: 21748296
Ref: A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver.
PMID: 22729936
Ref: Gefitinib and gemcitabine coordinately inhibited the proliferation of cholangiocarcinoma cells.
PMID: 23225424
 Ref: Sequence dependence of MEK inhibitor AZD6244 combined with gemcitabine for the treatment of biliary cancer.
PMID: 23091117
Ref: Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma.
PMID: 23254774
Ref: Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis.
PMID: 23315987
Ref: CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2.
PMID: 24179538
Ref: Protective Effects of Guava Pulp on Cholestatic Liver Injury.
PMID: 27335829
 Ref: Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-kappaB pathway.
PMID: 24486723
Ref: MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway.
PMID: 24658096
Ref: Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2.
PMID: 24700501
 Ref: Up-regulation of 14-3-3zeta expression in intrahepatic cholangiocarcinoma and its clinical implications.
PMID: 25391422
Ref: Loss of angiotensin-converting enzyme 2 promotes growth of gallbladder cancer.
PMID: 25663464
Ref: Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway.
PMID: 25815516
Ref: Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44nu is an indicator for recurrence in advanced cancer.
PMID: 26572077
 Ref: TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.
PMID: 26420419
Ref: Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells.
PMID: 26470769
Ref: YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma.
PMID: 26781979
Ref: Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.
PMID: 26877611
Ref: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway.
PMID: 26992854
Ref: Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis.
PMID: 27035431
Ref: Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer.
PMID: 27084680
Ref: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation.
PMID: 27627808
Ref: Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway.
PMID: 27637083
 Ref: Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.
PMID: 28178656
Ref: The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer.
PMID: 28285962
Ref: Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer.
PMID: 28624624
Ref: Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling.
PMID: 29178939
 Ref: Metformin synergistically enhances antitumor activity of cisplatin in gallbladder cancer via the PI3K/AKT/ERK pathway.
PMID: 29110119
Ref: Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.
PMID: 29348467
Ref: Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of beta-Catenin.
PMID: 29415992
Ref: Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.
PMID: 29574153
Ref: MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.
PMID: 30322054