Primary Site >> Colorectal Cancer

Gene >> MAP2K5

Journal: J Mol Med (Berl). 2007 Mar;85(3):293-304. Epub 2006 Dec 2.
Title: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas.
Author: Lassmann, Silke|Weis, Roland|Makowiec, Frank|Roth, Jasmine|Danciu, Mihai|Hopt, Ulrich|Werner, Martin
PMID: 17143621
Journal: DNA Cell Biol. 2012 Mar;31(3):342-9.
Title: Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population.
Author: Diao, Dechang|Wang, Lei|Zhang, Jun-Xiao|Chen, Dianke|Liu, Huanliang|Wei, Yisheng|Lu, Jiachun|Peng, Junsheng|Wang, Jianping
PMID: 21861603
Journal: BMC Cancer. 2012 Mar 30;12:127.
Title: Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer.
Author: Hu, Bang|Ren, Donglin|Su, Dan|Lin, Hongcheng|Xian, Zhenyu|Wan, Xingyang|Zhang, Junxiao|Fu, Xinhui|Jiang, Li|Diao, Dechan|Fan, Xinjuan|Wang, Lei|Wang, Jianping
PMID: 22458985
Journal: Cancer Immunol Res. 2014 Aug;2(8):789-99.
Title: Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.
Author: Jiang, Hong|Wang, Ping|Li, Xiaohua|Wang, Qilong|Deng, Zhong-Bin|Zhuang, Xiaoying|Mu, Jingyao|Zhang, Lifeng|Wang, Baomei|Yan, Jun|Miller, Donald|Zhang, Huang-Ge
PMID: 24801835
Journal: FEBS J. 2015 Apr;282(8):1394-405.
Title: SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling.
Author: Mansour, Mohammed A|Hyodo, Toshinori|Ito, Satoko|Kurita, Kenji|Kokuryo, Toshio|Uehara, Keisuke|Nagino, Masato|Takahashi, Masahide|Hamaguchi, Michinari|Senga, Takeshi
PMID: 25662172
Journal: Cell Death Dis. 2015 Apr 9;6:e1718.
Title: Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-kappaB activation.
Author: Simoes, A E S|Pereira, D M|Gomes, S E|Brito, H|Carvalho, T|French, A|Castro, R E|Steer, C J|Thibodeau, S N|Rodrigues, C M P|Borralho, P M
PMID: 25855966
Journal: Cell Cycle. 2016;15(4):506-18.
Title: Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Author: Lochhead, Pamela A|Clark, Jonathan|Wang, Lan-Zhen|Gilmour, Lesley|Squires, Matthew|Gilley, Rebecca|Foxton, Caroline|Newell, David R|Wedge, Stephen R|Cook, Simon J
PMID: 26959608
Journal: Oncotarget. 2016 Jun 7;7(23):34322-40.
Title: MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism.
Author: Pereira, Diane M|Simoes, Andre E S|Gomes, Sofia E|Castro, Rui E|Carvalho, Tania|Rodrigues, Cecilia M P|Borralho, Pedro M
PMID: 27144434
Journal: BMC Cancer. 2016 May 9;16:302.
Title: MEK5 overexpression is associated with the occurrence and development of colorectal cancer.
Author: Diao, Dechang|Wang, Lei|Wan, Jin|Chen, Zhiqiang|Peng, Junsheng|Liu, Huanliang|Chen, Xinlin|Wang, Wei|Zou, Liaonan
PMID: 27160304