Literatures

Primary Site >> Liver Cancer

Gene >> MAP2K1

1.
Journal:	Hepatology. 1997 Dec;26(6):1484-91.
Title:	Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma.
Author:	McKillop, I H\|Schmidt, C M\|Cahill, P A\|Sitzmann, J V
PMID:	9397988

2.
Journal:	Biochem Biophys Res Commun. 1997 Jul 9;236(1):54-8.
Title:	Increased MAPK expression and activity in primary human hepatocellular carcinoma.
Author:	Schmidt, C M\|McKillop, I H\|Cahill, P A\|Sitzmann, J V
PMID:	9223425

3.
Journal:	Hepatology. 2000 Nov;32(5):958-61.
Title:	Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha.
Author:	Hayashi, J\|Aoki, H\|Kajino, K\|Moriyama, M\|Arakawa, Y\|Hino, O
PMID:	11050045

4.
Journal:	Int J Cancer. 2001 Apr 1;92(1):55-62.
Title:	The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells.
Author:	Mitsui, H\|Takuwa, N\|Maruyama, T\|Maekawa, H\|Hirayama, M\|Sawatari, T\|Hashimoto, N\|Takuwa, Y\|Kimura, S
PMID:	11279606

5.
Journal:	Oncogene. 2001 May 3;20(20):2606-10.
Title:	Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein.
Author:	Giambartolomei, S\|Covone, F\|Levrero, M\|Balsano, C
PMID:	11420671

6.
Journal:	Hepatology. 2001 Jul;34(1):62-71.
Title:	Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of beta1 integrins.
Author:	Torimura, T\|Ueno, T\|Kin, M\|Harada, R\|Nakamura, T\|Kawaguchi, T\|Harada, M\|Kumashiro, R\|Watanabe, H\|Avraham, R\|Sata, M
PMID:	11431735

7.
Journal:	J Hepatol. 2001 Aug;35(2):245-53.
Title:	Laminin deposition to type IV collagen enhances haptotaxis, chemokinesis, and adhesion of hepatoma cells through beta1-integrins.
Author:	Torimura, T\|Ueno, T\|Kin, M\|Harad, R\|Nakamura, T\|Sakamoto, M\|Kumashiro, R\|Yano, H\|Kojiro, M\|Sata, M
PMID:	11580147

8.
Journal:	World J Gastroenterol. 2003 Apr;9(4):683-7.
Title:	Gene expression profiles of hepatoma cell line HLE.
Author:	Liu, Lian-Xin\|Liu, Zhi-Hua\|Jiang, Hong-Chi\|Zhang, Wei-Hui\|Qi, Shu-Yi\|Hu, Jie\|Wang, Xiu-Qin\|Wu, Min
PMID:	12679910

9.
Journal:	BMC Gastroenterol. 2003 Aug 8;3:19.
Title:	Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis.
Author:	Huynh, Hung\|Nguyen, Thi Thanh Tuyen\|Chow, Kah-Hoe Pierce\|Tan, Puay Hoon\|Soo, Khee Chee\|Tran, Evelyne
PMID:	12906713

10.
Journal:	Oncol Rep. 2003 Nov-Dec;10(6):1771-5.
Title:	Expression of cell cycle/growth regulator genes in human hepatocellular carcinoma and adjacent normal liver tissues.
Author:	Liu, Lian-Xin\|Jiang, Hong-Chi\|Liu, Zhi-Hua\|Zhu, An-Long\|Zhang, Wei-Hui\|Wu, Lin-Feng\|Zhou, Jing\|Wang, Xiu-Qin\|Wu, Min
PMID:	14534694

11.
Journal:	Int J Cancer. 2004 May 10;109(6):867-74.
Title:	c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line.
Author:	Sugioka, Yoshihiko\|Watanabe, Tetsu\|Inagaki, Yutaka\|Kushida, Miwa\|Niioka, Maki\|Endo, Hitoshi\|Higashiyama, Reiichi\|Okazaki, Isao
PMID:	15027120

12.
Journal:	Int J Oncol. 2004 Dec;25(6):1839-47.
Title:	Extracellular signal-regulated kinase induces cyclin D1 and Cdk-2 expression and phosphorylation of retinoblastoma in hepatocellular carcinoma.
Author:	Huynh, H\|Do, P T\|Nguyen, T H\|Chow, P\|Tan, P H\|Quach, T H\|Van, T\|Soo, K C\|Tran, E
PMID:	15547725

13.
Journal:	Clin Exp Metastasis. 2005;22(2):137-47.
Title:	Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis.
Author:	Nakanishi, Hayao\|Yasui, Kenzo\|Ikehara, Yuzuru\|Yokoyama, Hiroyuki\|Munesue, Seiichi\|Kodera, Yasuhiro\|Tatematsu, Masae
PMID:	16086234

14.
Journal:	Cancer Lett. 2006 Jul 28;239(1):27-35.
Title:	Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.
Author:	Wen-Sheng, Wu
PMID:	16169661

15.
Journal:	FEBS Lett. 2006 Jan 23;580(2):703-10.
Title:	Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.
Author:	Biswas, Kamal Krishna\|Tancharoen, Salunya\|Sarker, Krishna Pada\|Kawahara, Ko-ichi\|Hashiguchi, Teruto\|Maruyama, Ikuro
PMID:	16412424

16.
Journal:	Lab Invest. 2006 Jul;86(7):687-96.
Title:	MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells.
Author:	Honma, Nobuyuki\|Genda, Takuya\|Matsuda, Yasunobu\|Yamagiwa, Satoshi\|Takamura, Masaaki\|Ichida, Takafumi\|Aoyagi, Yutaka
PMID:	16636681

17.
Journal:	Cancer Lett. 2007 Mar 18;247(2):336-44.
Title:	siRNA targeted against HAb18G/CD147 inhibits MMP-2 secretion, actin and FAK expression in hepatocellular carcinoma cell line via ERK1/2 pathway.
Author:	Xu, Hui-Yun\|Qian, Ai-Rong\|Shang, Peng\|Xu, Jing\|Kong, Ling-Min\|Bian, Hui-Jie\|Chen, Zhi-Nan
PMID:	16815629

18.
Journal:	Mol Cancer Ther. 2007 Jan;6(1):138-46.
Title:	Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma.
Author:	Huynh, Hung\|Soo, Khee Chee\|Chow, Pierce K H\|Tran, Evelyn
PMID:	17237274

19.
Journal:	Biochem Biophys Res Commun. 2007 Oct 19;362(2):307-12.
Title:	Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells.
Author:	Hong, Hye-Young\|Kim, Byung-Chul
PMID:	17707342

20.
Journal:	Cancer Biol Ther. 2007 Sep;6(9):1461-8. Epub 2007 Jun 26.
Title:	Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway.
Author:	Cusimano, Antonella\|Fodera, Daniela\|D'Alessandro, Natale\|Lampiasi, Nadia\|Azzolina, Antonina\|Montalto, Giuseppe\|Cervello, Melchiorre
PMID:	18424914

21.
Journal:	Mol Cancer Ther. 2008 Sep;7(9):2633-48.
Title:	Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Author:	Park, Margaret A\|Zhang, Guo\|Mitchell, Clint\|Rahmani, Mohamed\|Hamed, Hossein\|Hagan, Michael P\|Yacoub, Adly\|Curiel, David T\|Fisher, Paul B\|Grant, Steven\|Dent, Paul
PMID:	18790746

22.
Journal:	Tumori. 2008 Jul-Aug;94(4):523-30.
Title:	Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma.
Author:	Lee, Kyung Hee\|Choi, Eun Young\|Hyun, Myung Soo\|Eun, Jong Ryul\|Jang, Byung Ik\|Kim, Tae Nyeun\|Lee, Heon Ju\|Lee, Dong Shik\|Yun, Sung Su\|Kim, Hong Jin\|Kim, Jung Hye\|Kim, Jae-Ryong
PMID:	18822689

23.
Journal:	Hepatology. 2009 Apr;49(4):1277-86.
Title:	CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis.
Author:	Ding, Wei\|Mouzaki, Marialena\|You, Hanning\|Laird, Joshua C\|Mato, Jose\|Lu, Shelly C\|Rountree, C Bart
PMID:	19115422

24.
Journal:	World J Gastroenterol. 2009 Dec 21;15(47):5924-35.
Title:	TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies.
Author:	Koehler, Bruno-Christian\|Urbanik, Toni\|Vick, Binje\|Boger, Regina-Johanna\|Heeger, Steffen\|Galle, Peter-R\|Schuchmann, Marcus\|Schulze-Bergkamen, Henning
PMID:	20014456

25.
Journal:	IUBMB Life. 2009 Jun;61(6):685-92.
Title:	Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway.
Author:	Song, Chunjiao\|Wang, Weimin\|Li, Meng\|Liu, Yanxin\|Zheng, Dexian
PMID:	19472191

26.
Journal:	J Hepatol. 2009 Jun;50(6):1112-21.
Title:	Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo.
Author:	Lai, Jin-Ping\|Sandhu, Dalbir S\|Moser, Catherine D\|Cazanave, Sophie C\|Oseini, Abdul M\|Shire, Abdirashid M\|Shridhar, Viji\|Sanderson, Schuyler O\|Roberts, Lewis R
PMID:	19376607

27.
Journal:	J Cell Mol Med. 2009 Aug;13(8B):2673-83.
Title:	Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma.
Author:	Huynh, Hung\|Ngo, Van Chanh\|Koong, Heng Nung\|Poon, Donald\|Choo, Su Pin\|Thng, Choon Hua\|Chow, Pierce\|Ong, Hock Soo\|Chung, Alexander\|Soo, Khee Chee
PMID:	19220580

28.
Journal:	Anticancer Res. 2009 Apr;29(4):1349-54.
Title:	G2-phase arrest through p21(WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells.
Author:	Yoshida, Mitsuzi\|Matsui, Yuki\|Iizuka, Akira\|Ikarashi, Yoshinori
PMID:	19414386

29.
Journal:	Int J Cancer. 2010 Mar 15;126(6):1367-77.
Title:	RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo.
Author:	Gailhouste, Luc\|Ezan, Frederic\|Bessard, Anne\|Fremin, Christophe\|Rageul, Julie\|Langouet, Sophie\|Baffet, Georges
PMID:	19816936

30.
Journal:	Eur J Surg Oncol. 2011 Jun;37(6):513-20.
Title:	Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma.
Author:	Chen, L\|Shi, Y\|Jiang, C-Y\|Wei, L-X\|Wang, Y-L\|Dai, G-H
PMID:	21324414

31.
Journal:	Eur J Cancer. 2011 May;47(7):1115-24.
Title:	Des-gamma-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway.
Author:	Yue, Pan\|Gao, Zu-Hua\|Xue, Xia\|Cui, Shu-Xiang\|Zhao, Cui-Rong\|Yuan, Yi\|Yin, Zhe\|Inagaki, Yoshinori\|Kokudo, Norihiro\|Tang, Wei\|Qu, Xian-Jun
PMID:	21349701

32.
Journal:	Autophagy. 2011 Oct;7(10):1159-72.
Title:	Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis.
Author:	Shi, Ying-Hong\|Ding, Zhen-Bin\|Zhou, Jian\|Hui, Bo\|Shi, Guo-Ming\|Ke, Ai-Wu\|Wang, Xiao-Ying\|Dai, Zhi\|Peng, Yuan-Fei\|Gu, Cheng-Yu\|Qiu, Shuang-Jian\|Fan, Jia
PMID:	21691147

33.
Journal:	Cancer Prev Res (Phila). 2011 Dec;4(12):2092-100.
Title:	Possible role of visfatin in hepatoma progression and the effects of branched-chain amino acids on visfatin-induced proliferation in human hepatoma cells.
Author:	Ninomiya, Soranobu\|Shimizu, Masahito\|Imai, Kenji\|Takai, Koji\|Shiraki, Makoto\|Hara, Takeshi\|Tsurumi, Hisashi\|Ishizaki, Sonoko\|Moriwaki, Hisataka
PMID:	21952585

34.
Journal:	Int J Oncol. 2012 Sep;41(3):969-78.
Title:	Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling.
Author:	Liang, Rong-Rui\|Zhang, Shu\|Qi, Jun-An\|Wang, Zhi-Dong\|Li, Jun\|Liu, Pei-Jun\|Huang, Chen\|Le, Xiao-Feng\|Yang, Jun\|Li, Zong-Fang
PMID:	22684543

35.
Journal:	Int J Hepatol. 2012;2012:328372.
Title:	The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control.
Author:	Guegan, Jean-Philippe\|Fremin, Christophe\|Baffet, Georges
PMID:	23133759

36.
Journal:	Int J Biochem Cell Biol. 2012 Dec;44(12):2212-22.
Title:	CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability.
Author:	Liu, Wen-Hsin\|Chen, Yeh-Long\|Chang, Long-Sen
PMID:	22964005

37.
Journal:	Biotechnol J. 2012 Nov;7(11):1395-404.
Title:	Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival.
Author:	Berger, Emmanuelle\|Vega, Nathalie\|Vidal, Hubert\|Geloen, Alain
PMID:	22930530

38.
Journal:	PLoS One. 2012;7(5):e37700.
Title:	Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway.
Author:	Deng, Zhongfan\|Yan, Huijuan\|Hu, Jiajie\|Zhang, Shengwei\|Peng, Peng\|Liu, Qingzhen\|Guo, Deyin
PMID:	22662193

39.
Journal:	Arch Toxicol. 2012 Mar;86(3):497-507.
Title:	Mechanistic study on liver tumor promoting effects of flutamide in rats.
Author:	Tawfeeq, Mohammad Monir\|Hayashi, Hitomi\|Shimamoto, Keisuke\|Suzuki, Kazuhiko\|Shibutani, Makoto\|Inokuma, Hisashi\|Mitsumori, Kunitoshi
PMID:	22076107

40.
Journal:	Mol Clin Oncol. 2013 Jan;1(1):29-34.
Title:	Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines.
Author:	Kanno, Syu-Ichi\|Itoh, Katsuyuki\|Suzuki, Naoto\|Tomizawa, Ayako\|Yomogida, Shin\|Ishikawa, Masaaki
PMID:	24649118

41.
Journal:	J Biol Chem. 2013 Dec 27;288(52):36994-7009.
Title:	Mechanism of hepatitis C virus (HCV)-induced osteopontin and its role in epithelial to mesenchymal transition of hepatocytes.
Author:	Iqbal, Jawed\|McRae, Steven\|Banaudha, Krishna\|Mai, Thi\|Waris, Gulam
PMID:	24240095

42.
Journal:	FEBS Lett. 2013 Dec 11;587(24):3921-7.
Title:	MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer.
Author:	Li, Lanlan\|Wang, Jiayi\|Zhang, Yue\|Zhang, Yan\|Ma, Lifang\|Weng, Wenhao\|Qiao, Yongxia\|Xiao, Weifan\|Wang, Hongmei\|Yu, Wenjun\|Pan, Qiuhui\|He, Yunyan\|Sun, Fenyong
PMID:	24211253

43.
Journal:	Neoplasia. 2013 Oct;15(10):1161-71.
Title:	Allosteric MEK1/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits antitumor activity in preclinical murine and rat models of hepatocellular carcinoma.
Author:	Schmieder, Roberta\|Puehler, Florian\|Neuhaus, Roland\|Kissel, Maria\|Adjei, Alex A\|Miner, Jeffrey N\|Mumberg, Dominik\|Ziegelbauer, Karl\|Scholz, Arne
PMID:	24204195

44.
Journal:	PLoS One. 2013 Sep 6;8(9):e72927.
Title:	Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway.
Author:	Chen, Kunlun\|Zhang, Shu\|Ji, Yuanyuan\|Li, Jun\|An, Peng\|Ren, Hongtao\|Liang, Rongrui\|Yang, Jun\|Li, Zongfang
PMID:	24039823

45.
Journal:	Cancer Chemother Pharmacol. 2013 Jun;71(6):1417-25.
Title:	Preclinical evaluation of combined TKI-258 and RAD001 in hepatocellular carcinoma.
Author:	Chan, Stephen L\|Wong, Chi-Hang\|Lau, Cecilia P Y\|Zhou, Qian\|Hui, Connie W C\|Lui, Vivian W Y\|Ma, Brigette B Y\|Chan, Anthony T C\|Yeo, Winnie
PMID:	23546591

46.
Journal:	Chem Biol Drug Des. 2013 Jun;81(6):775-83.
Title:	Calmodulin as a potential target by which berberine induces cell cycle arrest in human hepatoma Bel7402 cells.
Author:	Ma, Chao\|Tang, Kailin\|Liu, Qi\|Zhu, Ruixin\|Cao, Zhiwei
PMID:	23421648

47.
Journal:	Biochem Biophys Res Commun. 2013 Apr 26;434(1):35-41.
Title:	The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells.
Author:	Zhang, Caixia\|He, Hongwei\|Zhang, Hao\|Yu, Dongke\|Zhao, Wuli\|Chen, Yi\|Shao, Rongguang
PMID:	23545258

48.
Journal:	Carcinogenesis. 2013 Jan;34(1):38-47.
Title:	MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells.
Author:	Guegan, Jean-Philippe\|Ezan, Frederic\|Theret, Nathalie\|Langouet, Sophie\|Baffet, Georges
PMID:	23042098

49.
Journal:	J Biol Chem. 2013 Jan 18;288(3):1726-38.
Title:	Peroxisome proliferator-activated receptor alpha positively regulates complement C3 expression but inhibits tumor necrosis factor alpha-mediated activation of C3 gene in mammalian hepatic-derived cells.
Author:	Mogilenko, Denis A\|Kudriavtsev, Igor V\|Shavva, Vladimir S\|Dizhe, Ella B\|Vilenskaya, Ekaterina G\|Efremov, Alexander M\|Perevozchikov, Andrej P\|Orlov, Sergey V
PMID:	23168409

50.
Journal:	Hepatology. 2013 Jun;57(6):2299-313.
Title:	MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.
Author:	Peng, Hui\|Dara, Lily\|Li, Tony W H\|Zheng, Yuhua\|Yang, Heping\|Tomasi, Maria Lauda\|Tomasi, Ivan\|Giordano, Pasquale\|Mato, Jose M\|Lu, Shelly C
PMID:	23325601

51.
Journal:	Oncol Rep. 2013 Feb;29(2):840-6.
Title:	Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma.
Author:	Huo, Xinying\|Zhang, Qi\|Liu, Angela M\|Tang, Cuiju\|Gong, Yongling\|Bian, Jianmin\|Luk, John M\|Xu, Zhi\|Chen, Jinfei
PMID:	23232767

52.
Journal:	Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014;158(1):39-43.
Title:	Valproate activates ERK signaling pathway in primary human hepatocytes.
Author:	Bitman, Michal\|Vrzal, Radim\|Dvorak, Zdenek\|Pavek, Petr
PMID:	23073524

53.
Journal:	Oncol Rep. 2014 Jan;31(1):488-96.
Title:	Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma.
Author:	Wang, Jian-Gang\|Zheng, Xing-Xing\|Zeng, Guang-Yao\|Zhou, Ying-Jun\|Yuan, Hong
PMID:	24247909

54.
Journal:	Clin Cancer Res. 2014 May 1;20(9):2410-23.
Title:	BRaf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma.
Author:	Breunig, Christian\|Mueller, Bernadett J\|Umansky, Ludmila\|Wahl, Kristin\|Hoffmann, Katrin\|Lehner, Frank\|Manns, Michael P\|Bantel, Heike\|Falk, Christine S
PMID:	24573550

55.
Journal:	Oncotarget. 2014 May 30;5(10):3012-22.
Title:	Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing.
Author:	Janku, Filip\|Kaseb, Ahmed O\|Tsimberidou, Apostolia M\|Wolff, Robert A\|Kurzrock, Razelle
PMID:	24931142

56.
Journal:	Chin J Nat Med. 2014 Jun;12(6):443-8.
Title:	The forecast of anticancer targets of cryptotanshinone based on reverse pharmacophore-based screening technology.
Author:	Yuan, Dong-Ping\|Long, Jun\|Lu, Yin\|Lin, Jie\|Tong, Li
PMID:	24969525

57.
Journal:	Zhongguo Zhong Yao Za Zhi. 2014 Apr;39(7):1276-9.
Title:	[Role of ERK/FoxO3a signal axis in inhibitory effect of vitexin 1 (VB-1) in HepG2 cell proliferation].
Author:	Zheng, Xing-Xing\|Zhang, Ren-Shuo\|Zhou, Ying-Jun\|Wang, Jian-Gang
PMID:	25011268

58.
Journal:	Am J Pathol. 2015 Apr;185(4):1135-44.
Title:	Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Author:	Peng, Hui\|Li, Tony W H\|Yang, Heping\|Moyer, Mary P\|Mato, Jose M\|Lu, Shelly C
PMID:	25794709

59.
Journal:	Life Sci. 2015 Dec 1;142:19-25.
Title:	Molecular mechanisms underlying anticancer effects of myricetin.
Author:	Devi, Kasi Pandima\|Rajavel, Tamilselvam\|Habtemariam, Solomon\|Nabavi, Seyed Fazel\|Nabavi, Seyed Mohammad
PMID:	26455550

60.
Journal:	Toxicology. 2015 Oct 2;336:36-47.
Title:	Hexachlorobenzene induces cell proliferation, and aryl hydrocarbon receptor expression (AhR) in rat liver preneoplastic foci, and in the human hepatoma cell line HepG2. AhR is a mediator of ERK1/2 signaling, and cell cycle regulation in HCB-treated HepG2
Author:	de Tomaso Portaz, Ana Clara\|Caimi, Giselle Romero\|Sanchez, Marcela\|Chiappini, Florencia\|Randi, Andrea S\|Kleiman de Pisarev, Diana L\|Alvarez, Laura
PMID:	26219504

61.
Journal:	Int J Clin Exp Med. 2015 Mar 15;8(3):4087-93. eCollection 2015.
Title:	MEK1 expression and its relationship with clinical pathological features in hepatocellular carcinoma.
Author:	Gong, Renhua\|Sun, Dengqun\|Zhong, Xingguo\|Sun, Yanjun\|Li, Li
PMID:	26064314

62.
Journal:	Oncotarget. 2015 Aug 28;6(25):20964-76.
Title:	Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma.
Author:	Chan, Lo-Kong\|Chiu, Yung-Tuen\|Sze, Karen Man-Fong\|Ng, Irene Oi-Lin
PMID:	26035355

63.
Journal:	Int J Cancer. 2015 Sep 15;137(6):1341-51.
Title:	Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications.
Author:	Liao, Yi-Jen\|Fang, Cheng-Chieh\|Yen, Chia-Hung\|Hsu, Shih-Ming\|Wang, Chung-Kwe\|Huang, Shiu-Feng\|Liang, Yu-Chih\|Lin, Ying-Yu\|Chu, Yu-Tseng\|Arthur Chen, Yi-Ming
PMID:	25754535

64.
Journal:	Chem Biol Interact. 2015 Jun 5;234:274-81.
Title:	Down-regulation of aldo-keto reductase AKR1B10 gene expression by a phorbol ester via the ERK/c-Jun signaling pathway.
Author:	Nishinaka, Toru\|Miura, Takeshi\|Sakou, Mihoko\|Hidaka, Chiemi\|Sasaoka, Chisato\|Okamura, Asuka\|Okamoto, Atsushi\|Terada, Tomoyuki
PMID:	25463304

65.
Journal:	Biochem Pharmacol. 2015 Jan 1;93(1):110-24.
Title:	Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis.
Author:	Lin, Yi-Te\|Lu, Hsing-Pang\|Chao, Chuck C-K
PMID:	25451688

66.
Journal:	BMC Med Genomics. 2016 Dec 12;9(1):75.
Title:	Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes.
Author:	Wong, John K L\|Campbell, Desmond\|Ngo, Ngoc Diem\|Yeung, Fanny\|Cheng, Guo\|Tang, Clara S M\|Chung, Patrick H Y\|Tran, Ngoc Son\|So, Man-Ting\|Cherny, Stacey S\|Sham, Pak C\|Tam, Paul K\|Garcia-Barcelo, Maria-Merce
PMID:	27955658

67.
Journal:	J Hepatol. 2016 Nov;65(5):963-971.
Title:	Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis.
Author:	Magdaleno, Fernando\|Arriazu, Elena\|Ruiz de Galarreta, Marina\|Chen, Yu\|Ge, Xiaodong\|Conde de la Rosa, Laura\|Nieto, Natalia
PMID:	27318326

68.
Journal:	Oncotarget. 2016 Jun 28;7(26):39694-39704.
Title:	Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis.
Author:	Yang, Xuejun\|Sun, Deguang\|Dong, Chengyong\|Tian, Yu\|Gao, Zhenming\|Wang, Liming
PMID:	27175589

69.
Journal:	J Hepatol. 2016 Aug;65(2):325-33.
Title:	Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Author:	Bissig-Choisat, Beatrice\|Kettlun-Leyton, Claudia\|Legras, Xavier D\|Zorman, Barry\|Barzi, Mercedes\|Chen, Leon L\|Amin, Mansi D\|Huang, Yung-Hsin\|Pautler, Robia G\|Hampton, Oliver A\|Prakash, Masand M\|Yang, Diane\|Borowiak, Malgorzata\|Muzny, Donna\|Doddapaneni, Har
PMID:	27117591

70.
Journal:	Biochem Biophys Res Commun. 2016 May 27;474(2):330-337.
Title:	MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models.
Author:	Wang, Kaifeng\|Fan, Yaohua\|Chen, Gongying\|Wang, Zhengrong\|Kong, Dexin\|Zhang, Peng
PMID:	27107695

71.
Journal:	Oncol Lett. 2016 Jan;11(1):610-618.
Title:	Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma.
Author:	Zhang, Zhi\|Zhang, Hanguang\|Peng, Tao\|Li, Dongdong\|Xu, Jing
PMID:	26870255

72.
Journal:	PLoS One. 2016 Jan 14;11(1):e0146696.
Title:	Hepatitis B Virus HBx Activates Notch Signaling via Delta-Like 4/Notch1 in Hepatocellular Carcinoma.
Author:	Kongkavitoon, Pornrat\|Tangkijvanich, Pisit\|Hirankarn, Nattiya\|Palaga, Tanapat
PMID:	26766040

73.
Journal:	Life Sci. 2016 Jan 1;144:121-8.
Title:	Identification of intracellular pathways through which TGF-beta1 upregulates URG-4/URGCP gene expression in hepatoma cells.
Author:	Tokay, Esra\|Kockar, Feray
PMID:	26657209

74.
Journal:	Tumour Biol. 2016 May;37(5):5837-46.
Title:	Glabridin arrests cell cycle and inhibits proliferation of hepatocellular carcinoma by suppressing braf/MEK signaling pathway.
Author:	Wang, Ziyou\|Luo, Shengqun\|Wan, Zheng\|Chen, Chuyan\|Zhang, Xiangning\|Li, Binbin\|Huang, GuoLiang\|Chen, Liyong\|He, Zhiwei\|Huang, Zunnan
PMID:	26586395

75.
Journal:	Tumour Biol. 2016 Apr;37(4):4399-408.
Title:	HMGB1 promotes HCC progression partly by downregulating p21 via ERK/c-Myc pathway and upregulating MMP-2.
Author:	Chen, Yanmei\|Lin, Chengzhao\|Liu, Yang\|Jiang, Yan
PMID:	26499944

76.
Journal:	Oncogene. 2016 May 19;35(20):2547-61.
Title:	Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy.
Author:	Mandal, R\|Becker, S\|Strebhardt, K
PMID:	26364606

77.
Journal:	Oncotarget. 2016 Apr 12;7(15):20597-611.
Title:	MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization.
Author:	Cheng, Jiamin\|Liu, Chungang\|Liu, Limei\|Chen, Xuejiao\|Shan, Juanjuan\|Shen, Junjie\|Zhu, Wei\|Qian, Cheng
PMID:	26967560

78.
Journal:	J Mol Med (Berl). 2017 Nov;95(11):1237-1249.
Title:	Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.
Author:	Lin, Bonan\|Zhou, Xiaomeng\|Lin, Shuye\|Wang, Xiaoyue\|Zhang, Meiying\|Cao, Baoping\|Dong, Yan\|Yang, Shuai\|Wang, Ji Ming\|Guo, Mingzhou\|Huang, Jiaqiang
PMID:	28844099

79.
Journal:	Cancer Lett. 2017 Dec 28;411:117-129.
Title:	BMP4 promotes oxaliplatin resistance by an induction of epithelial-mesenchymal transition via MEK1/ERK/ELK1 signaling in hepatocellular carcinoma.
Author:	Ma, Junli\|Zeng, Shan\|Zhang, Yan\|Deng, Ganlu\|Qu, Yanling\|Guo, Cao\|Yin, Ling\|Han, Ying\|Cai, Changjing\|Li, Yiyi\|Wang, Guqi\|Bonkovsky, Herbert L\|Shen, Hong
PMID:	28987388

80.
Journal:	Oncoimmunology. 2017 May 26;6(9):e1333213.
Title:	Colony-stimulating factor-1-induced AIF1 expression in tumor-associated macrophages enhances the progression of hepatocellular carcinoma.
Author:	Cai, Hao\|Zhu, Xiao-Dong\|Ao, Jian-Yang\|Ye, Bo-Gen\|Zhang, Yuan-Yuan\|Chai, Zong-Tao\|Wang, Cheng-Hao\|Shi, Wen-Kai\|Cao, Man-Qing\|Li, Xiao-Long\|Sun, Hui-Chuan
PMID:	28932635

81.
Journal:	Oncotarget. 2017 Jul 6;8(34):57109-57120.
Title:	Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib.
Author:	Rohr-Udilova, Nataliya\|Klinglmuller, Florian\|Seif, Martha\|Hayden, Hubert\|Bilban, Martin\|Pinter, Matthias\|Stolze, Klaus\|Sieghart, Wolfgang\|Peck-Radosavljevic, Markus\|Trauner, Michael
PMID:	28915658

82.
Journal:	Oncotarget. 2017 Jul 5;8(33):55084-55093.
Title:	Tumor-specific hepatic stellate cells (tHSCs) induces DIgR2 expression in dendritic cells to inhibit T cells.
Author:	Xia, Yun-Hong\|Lu, Zhen\|Zhao, Min\|Dai, Wen-Ting\|Ding, Lu\|Hu, Li-Xia\|Jiang, Guo-Lin
PMID:	28903404

83.
Journal:	Environ Toxicol. 2017 Nov;32(11):2360-2370.
Title:	beta-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways.
Author:	Huang, Chien-Feng\|Teng, Ying-Hock\|Lu, Fung-Jou\|Hsu, Wen-Hung\|Lin, Chia-Liang\|Hung, Chia-Chen\|Tung, Jai-Nien\|Hsieh, Yi-Hsien\|Liu, Chung-Jung
PMID:	28722351

84.
Journal:	Oncol Res. 2017 Nov 2;25(9):1607-1616.
Title:	Inhibition of ERK1/2 Signaling Impairs the Promoting Effects of TGF-beta1 on Hepatocellular Carcinoma Cell Invasion and Epithelial-Mesenchymal Transition.
Author:	Liu, Ling\|Li, Nianfeng\|Zhang, Qi\|Zhou, Jixiang\|Lin, Ling\|He, Xinxin
PMID:	28492136

85.
Journal:	Glycoconj J. 2017 Aug;34(4):489-498.
Title:	Ulva pertusa lectin 1 delivery through adenovirus vector affects multiple signaling pathways in cancer cells.
Author:	Li, Gongchu\|Zhao, Zhenzhen\|Wu, Bingbing\|Su, Qunshu\|Wu, Liqin\|Yang, Xinyan\|Chen, Jing
PMID:	28349379

86.
Journal:	Sci Rep. 2017 Mar 24;7(1):396.
Title:	FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Author:	Zhang, Qiao-Yan\|Yue, Xiao-Qiang\|Jiang, Yi-Ping\|Han, Ting\|Xin, Hai-Liang
PMID:	28341836

87.
Journal:	Biomed Pharmacother. 2017 Feb;86:27-31.
Title:	Contrary influence of clinically applied sorafenib concentrations among hepatocellular carcinoma patients.
Author:	Lin, Zu-Yau\|Chuang, Wan-Long
PMID:	27936391

88.
Journal:	Cancer Lett. 2017 Mar 1;388:167-176.
Title:	Ectopic overexpression of filamin C scaffolds MEK1/2 and ERK1/2 to promote the progression of human hepatocellular carcinoma.
Author:	Yang, Baicai\|Liu, Yun\|Zhao, Jie\|Hei, Kaiwen\|Zhuang, Hao\|Li, Qiang\|Wei, Wen\|Chen, Ruibing\|Zhang, Ning\|Li, Yongmei
PMID:	27919788

89.
Journal:	Exp Mol Pathol. 2018 Feb;104(1):45-49.
Title:	Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis.
Author:	Nguyen, Luan\|Masouminia, Maryam\|Mendoza, Alejandro\|Samadzadeh, Sara\|Tillman, Brittany\|Morgan, Timothy\|French, Barbara\|French, Samuel
PMID:	29307797

90.
Journal:	Cancer Res. 2018 May 1;78(9):2219-2232.
Title:	Demethylation-Induced Overexpression of Shc3 Drives c-Raf-Independent Activation of MEK/ERK in HCC.
Author:	Liu, Yun\|Zhang, Xinran\|Yang, Baicai\|Zhuang, Hao\|Guo, Hua\|Wei, Wen\|Li, Yuan\|Chen, Ruibing\|Li, Yongmei\|Zhang, Ning
PMID:	29330146

91.
Journal:	Int J Med Sci. 2018 Jan 1;15(1):69-76.
Title:	Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma in Vitro and in Vivo.
Author:	Kang, Xueqing\|Wang, Feng\|Lan, Xiuwan\|Li, Xiaolong\|Zheng, Shunxin\|Lv, Zhilue\|Zhuang, Yuan\|Zhao, Yongxiang\|Zhou, Sufang
PMID:	29333089

92.
Journal:	Cell Mol Biol (Noisy-le-grand). 2018 Apr 30;64(5):73-79.
Title:	RASSF7 promotes cell proliferation through activating MEK1/2-ERK1/2 signaling pathway in hepatocellular carcinoma.
Author:	Zhang, Min\|Li, Qiong\|Zhang, Lu\|Wang, Yunjian\|Wang, Linxia\|Li, Qingjun\|He, Tao\|Wan, Baishun\|Wang, Xiaoqian
PMID:	29729697

93.
Journal:	Biosci Trends. 2018 Jul 17;12(3):291-297.
Title:	Cinobufacini inhibits epithelial-mesenchymal transition of human hepatocellular carcinoma cells through c-Met/ERK signaling pathway.
Author:	Qi, Fanghua\|Wang, Jinjing\|Zhao, Lin\|Cai, Pingping\|Tang, Wei\|Wang, Zhixue
PMID:	29794405

94.
Journal:	J Hepatol. 2018 Jul 18. pii: S0168-8278(18)32184-6.
Title:	Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer.
Author:	Wang, Cun\|Jin, Haojie\|Gao, Dongmei\|Lieftink, Cor\|Evers, Bastiaan\|Jin, Guangzhi\|Xue, Zheng\|Wang, Liqin\|Beijersbergen, Roderick L\|Qin, Wenxin\|Bernards, Rene
PMID:	30030148

95.
Journal:	Biochem Biophys Res Commun. 2018 Sep 11. pii: S0006-291X(18)31758-3.
Title:	Down-regulation of MAP2K1 by miR-539 inhibits hepatocarcinoma progression.
Author:	Cui, Xiangdan\|Zhang, Aijun\|Liu, Jianwei\|Wu, Kangkang\|Chen, Zhengfeng\|Wang, Qing
PMID:	30217449

96.
Journal:	Mol Carcinog. 2018 Oct 26.
Title:	lncRNA DRHC inhibits proliferation and invasion in hepatocellular carcinoma via c-Myb-regulated MEK/ERK signaling.
Author:	Zhuang, Runzhou\|Zhang, Xuanyu\|Lu, Di\|Wang, Jianguo\|Zhuo, Jianyong\|Wei, Xuyong\|Ling, Qi\|Xie, Haiyang\|Zheng, Shusen\|Xu, Xiao
PMID:	30362626