Primary Site >> Liver Cancer
Gene >> MAP2K1
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Ref: Increased MAPK expression and activity in primary human hepatocellular carcinoma. PMID: 9223425 Ref: Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. PMID: 9397988 |
Ref: Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. PMID: 11050045 |
Ref: The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells. PMID: 11279606 Ref: Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein. PMID: 11420671 Ref: Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of beta1 integrins. PMID: 11431735 Ref: Laminin deposition to type IV collagen enhances haptotaxis, chemokinesis, and adhesion of hepatoma cells through beta1-integrins. PMID: 11580147 |
Ref: Gene expression profiles of hepatoma cell line HLE. PMID: 12679910 Ref: Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. PMID: 12906713 Ref: Expression of cell cycle/growth regulator genes in human hepatocellular carcinoma and adjacent normal liver tissues. PMID: 14534694 |
Ref: c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. PMID: 15027120 Ref: Extracellular signal-regulated kinase induces cyclin D1 and Cdk-2 expression and phosphorylation of retinoblastoma in hepatocellular carcinoma. PMID: 15547725 |
Ref: Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis. PMID: 16086234 |
Ref: Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. PMID: 16169661 Ref: Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt. PMID: 16412424 Ref: MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells. PMID: 16636681 |
Ref: siRNA targeted against HAb18G/CD147 inhibits MMP-2 secretion, actin and FAK expression in hepatocellular carcinoma cell line via ERK1/2 pathway. PMID: 16815629 Ref: Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. PMID: 17237274 Ref: Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells. PMID: 17707342 Ref: Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. PMID: 18424914 |
Ref: Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95. PMID: 18790746 Ref: Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma. PMID: 18822689 |
Ref: CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. PMID: 19115422 Ref: Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. PMID: 19220580 Ref: Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo. PMID: 19376607 Ref: G2-phase arrest through p21(WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells. PMID: 19414386 Ref: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway. PMID: 19472191 Ref: TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies. PMID: 20014456 |
Ref: RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo. PMID: 19816936 |
Ref: Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma. PMID: 21324414 Ref: Des-gamma-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway. PMID: 21349701 Ref: Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. PMID: 21691147 Ref: Possible role of visfatin in hepatoma progression and the effects of branched-chain amino acids on visfatin-induced proliferation in human hepatoma cells. PMID: 21952585 |
Ref: Mechanistic study on liver tumor promoting effects of flutamide in rats. PMID: 22076107 Ref: Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. PMID: 22662193 Ref: Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling. PMID: 22684543 Ref: Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival. PMID: 22930530 Ref: CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability. PMID: 22964005 Ref: The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control. PMID: 23133759 |
Ref: MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells. PMID: 23042098 Ref: Peroxisome proliferator-activated receptor alpha positively regulates complement C3 expression but inhibits tumor necrosis factor alpha-mediated activation of C3 gene in mammalian hepatic-derived cells. PMID: 23168409 Ref: Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma. PMID: 23232767 Ref: MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. PMID: 23325601 Ref: Calmodulin as a potential target by which berberine induces cell cycle arrest in human hepatoma Bel7402 cells. PMID: 23421648 Ref: The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells. PMID: 23545258 Ref: Preclinical evaluation of combined TKI-258 and RAD001 in hepatocellular carcinoma. PMID: 23546591 Ref: Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway. PMID: 24039823 Ref: Allosteric MEK1/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits antitumor activity in preclinical murine and rat models of hepatocellular carcinoma. PMID: 24204195 Ref: MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. PMID: 24211253 Ref: Mechanism of hepatitis C virus (HCV)-induced osteopontin and its role in epithelial to mesenchymal transition of hepatocytes. PMID: 24240095 Ref: Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines. PMID: 24649118 |
Ref: Valproate activates ERK signaling pathway in primary human hepatocytes. PMID: 23073524 Ref: Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. PMID: 24247909 Ref: BRaf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma. PMID: 24573550 Ref: Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. PMID: 24931142 Ref: The forecast of anticancer targets of cryptotanshinone based on reverse pharmacophore-based screening technology. PMID: 24969525 Ref: [Role of ERK/FoxO3a signal axis in inhibitory effect of vitexin 1 (VB-1) in HepG2 cell proliferation]. PMID: 25011268 |
Ref: Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis. PMID: 25451688 Ref: Down-regulation of aldo-keto reductase AKR1B10 gene expression by a phorbol ester via the ERK/c-Jun signaling pathway. PMID: 25463304 Ref: Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications. PMID: 25754535 Ref: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells. PMID: 25794709 Ref: Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma. PMID: 26035355 Ref: MEK1 expression and its relationship with clinical pathological features in hepatocellular carcinoma. PMID: 26064314 Ref: Hexachlorobenzene induces cell proliferation, and aryl hydrocarbon receptor expression (AhR) in rat liver preneoplastic foci, and in the human hepatoma cell line HepG2. AhR is a mediator of ERK1/2 signaling, and cell cycle regulation in HCB-treated HepG2 PMID: 26219504 Ref: Molecular mechanisms underlying anticancer effects of myricetin. PMID: 26455550 |
Ref: Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy. PMID: 26364606 Ref: HMGB1 promotes HCC progression partly by downregulating p21 via ERK/c-Myc pathway and upregulating MMP-2. PMID: 26499944 Ref: Glabridin arrests cell cycle and inhibits proliferation of hepatocellular carcinoma by suppressing braf/MEK signaling pathway. PMID: 26586395 Ref: Identification of intracellular pathways through which TGF-beta1 upregulates URG-4/URGCP gene expression in hepatoma cells. PMID: 26657209 Ref: Hepatitis B Virus HBx Activates Notch Signaling via Delta-Like 4/Notch1 in Hepatocellular Carcinoma. PMID: 26766040 Ref: Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma. PMID: 26870255 Ref: MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization. PMID: 26967560 Ref: MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models. PMID: 27107695 Ref: Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. PMID: 27117591 Ref: Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis. PMID: 27175589 Ref: Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis. PMID: 27318326 Ref: Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes. PMID: 27955658 |
Ref: Ectopic overexpression of filamin C scaffolds MEK1/2 and ERK1/2 to promote the progression of human hepatocellular carcinoma. PMID: 27919788 Ref: Contrary influence of clinically applied sorafenib concentrations among hepatocellular carcinoma patients. PMID: 27936391 Ref: FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells. PMID: 28341836 Ref: Ulva pertusa lectin 1 delivery through adenovirus vector affects multiple signaling pathways in cancer cells. PMID: 28349379 Ref: Inhibition of ERK1/2 Signaling Impairs the Promoting Effects of TGF-beta1 on Hepatocellular Carcinoma Cell Invasion and Epithelial-Mesenchymal Transition. PMID: 28492136 Ref: beta-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. PMID: 28722351 Ref: Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma. PMID: 28844099 Ref: Tumor-specific hepatic stellate cells (tHSCs) induces DIgR2 expression in dendritic cells to inhibit T cells. PMID: 28903404 Ref: Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib. PMID: 28915658 Ref: Colony-stimulating factor-1-induced AIF1 expression in tumor-associated macrophages enhances the progression of hepatocellular carcinoma. PMID: 28932635 Ref: BMP4 promotes oxaliplatin resistance by an induction of epithelial-mesenchymal transition via MEK1/ERK/ELK1 signaling in hepatocellular carcinoma. PMID: 28987388 |
Ref: Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. PMID: 29307797 Ref: Demethylation-Induced Overexpression of Shc3 Drives c-Raf-Independent Activation of MEK/ERK in HCC. PMID: 29330146 Ref: Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma in Vitro and in Vivo. PMID: 29333089 Ref: RASSF7 promotes cell proliferation through activating MEK1/2-ERK1/2 signaling pathway in hepatocellular carcinoma. PMID: 29729697 Ref: Cinobufacini inhibits epithelial-mesenchymal transition of human hepatocellular carcinoma cells through c-Met/ERK signaling pathway. PMID: 29794405 Ref: Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer. PMID: 30030148 Ref: Down-regulation of MAP2K1 by miR-539 inhibits hepatocarcinoma progression. PMID: 30217449 Ref: lncRNA DRHC inhibits proliferation and invasion in hepatocellular carcinoma via c-Myb-regulated MEK/ERK signaling. PMID: 30362626 |