Primary Site >> Stomach Cancer

Gene >> MAP2K1

Journal: J Biol Chem. 1997 Oct 24;272(43):27015-24.
Title: Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells.
Author: Hocker, M|Henihan, R J|Rosewicz, S|Riecken, E O|Zhang, Z|Koh, T J|Wang, T C
PMID: 9341140
Journal: J Biol Chem. 1999 Jul 23;274(30):20961-9.
Title: Activation of human histidine decarboxylase gene promoter activity by gastrin is mediated by two distinct nuclear factors.
Author: Raychowdhury, R|Zhang, Z|Hocker, M|Wang, T C
PMID: 10409643
Journal: Cancer Res. 2001 Nov 15;61(22):8322-30.
Title: Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.
Author: Song, M S|Park, Y K|Lee, J H|Park, K
PMID: 11719466
Journal: Biochem Biophys Res Commun. 2002 Feb 1;290(4):1289-94.
Title: Extracellular signal-regulated protein kinases mediate H(+),K(+)-ATPase alpha-subunit gene expression.
Author: Kusayanagi, Satoshi|Takeuchi, Yoshiaki|Todisco, Andrea|Mitamura, Keiji
PMID: 11812003
Journal: Biochem Biophys Res Commun. 2002 Mar 8;291(4):868-74.
Title: Helicobacter pylori activates the proto-oncogene c-fos through SRE transactivation.
Author: Mitsuno, Yuzo|Maeda, Shin|Yoshida, Haruhiko|Hirata, Yoshihiro|Ogura, Keiji|Akanuma, Masao|Kawabe, Takao|Shiratori, Yasushi|Omata, Masao
PMID: 11866445
Journal: J Biol Chem. 2003 Mar 7;278(10):8190-8. Epub 2002 Dec 30.
Title: Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements.
Author: Schafer, Georgia|Cramer, Thorsten|Suske, Guntram|Kemmner, Wolfgang|Wiedenmann, Bertram|Hocker, Michael
PMID: 12509426
Journal: Cancer Res. 2003 Aug 1;63(15):4648-55.
Title: Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system.
Author: Lee, Dong Hoon|Yang, Young|Lee, Soon Jung|Kim, Kun-Yong|Koo, Tae Hyeon|Shin, Sun Mi|Song, Kyu Sang|Lee, Young Ho|Kim, Yung-Jin|Lee, Jung Joon|Choi, Inpyo|Lee, Jeong-Hyung
PMID: 12907645
Journal: Oncogene. 2004 Aug 26;23(39):6603-11.
Title: Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells.
Author: Hwang, Young S|Jeong, Min|Park, Jung S|Kim, Mi H|Lee, Dae B|Shin, Boo A|Mukaida, Naofumi|Ellis, Lee M|Kim, Hyeong R|Ahn, Bong W|Jung, Young D
PMID: 15208668
Journal: World J Gastroenterol. 2005 Feb 7;11(5):623-8.
Title: Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer.
Author: Liang, Bin|Wang, Shan|Zhu, Xue-Guang|Yu, Yong-Xiang|Cui, Zhi-Rong|Yu, You-Zhi
PMID: 15655810
Journal: Int J Oncol. 2005 Jun;26(6):1669-74.
Title: Extracellular signal-regulated kinase and AP-1 pathways are involved in reactive oxygen species-induced urokinase plasminogen activator receptor expression in human gastric cancer cells.
Author: Kim, Mi H|Cho, Hyung S|Jung, Min|Hong, Min H|Lee, Sam K|Shin, Boo A|Ahn, Bong W|Jung, Young D
PMID: 15870884
Journal: Clin Exp Metastasis. 2005;22(2):137-47.
Title: Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis.
Author: Nakanishi, Hayao|Yasui, Kenzo|Ikehara, Yuzuru|Yokoyama, Hiroyuki|Munesue, Seiichi|Kodera, Yasuhiro|Tatematsu, Masae
PMID: 16086234
Journal: Int J Cancer. 2006 Jun 15;118(12):2965-72.
Title: Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation.
Author: Xue, Yan|Bi, Feng|Zhang, Xueyong|Zhang, Siyuan|Pan, Yanglin|Liu, Na|Shi, Yongquan|Yao, Xuebiao|Zheng, Yi|Fan, Daiming
PMID: 16395716
Journal: Exp Mol Med. 2006 Feb 28;38(1):27-35.
Title: Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines.
Author: Lee, Kyung Hee|Choi, Eun Young|Kim, Min Kyoung|Hyun, Myung Soo|Jang, Byung Ik|Kim, Tae Nyeun|Kim, Sang Woon|Song, Sun Kyo|Kim, Jung Hye|Kim, Jae-Ryong
PMID: 16520550
Journal: J Gastrointest Surg. 2006 Apr;10(4):551-62.
Title: Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells.
Author: Abdel-Latif, Mohamed M M|Windle, Henry|Terres, Ana|Eidhin, Deirdre Ni|Kelleher, Dermot|Reynolds, John V
PMID: 16627221
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1726-37. Epub 2007 Mar
Title: Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.
Author: Tu, Shuiping|Chi, Alfred L|Lim, Seonhee|Cui, Guanglin|Dubeykovskaya, Zina|Ai, Wandong|Fleming, John V|Takaishi, Shigeo|Wang, Timothy C
PMID: 17332476
Journal: Mol Cancer Ther. 2008 Mar;7(3):530-7.
Title: p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR.
Author: Gong, Manman|Meng, Lin|Jiang, Beihai|Zhang, Jianzhi|Yang, Hua|Wu, Jian|Shou, Chengchao
PMID: 18347140
Journal: Oncol Rep. 2008 Dec;20(6):1569-75.
Title: EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells.
Author: Baek, Min K|Kim, Mi H|Jang, Hee J|Park, Jung S|Chung, Ik J|Shin, Boo A|Ahn, Bong W|Jung, Young D
PMID: 19020743
Journal: Mol Carcinog. 2009 Aug;48(8):703-12.
Title: Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer.
Author: Seto, Motoko|Ohta, Miki|Asaoka, Yoshinari|Ikenoue, Tsuneo|Tada, Motohisa|Miyabayashi, Koji|Mohri, Dai|Tanaka, Yasuo|Ijichi, Hideaki|Tateishi, Keisuke|Kanai, Fumihiko|Kawabe, Takao|Omata, Masao
PMID: 19142899
Journal: Mol Cancer Ther. 2009 Sep;8(9):2526-36.
Title: Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells.
Author: Yoon, Young-Kwang|Kim, Hwang-Phill|Han, Sae-Won|Hur, Hyung-Seok|Oh, Do Youn|Im, Seock-Ah|Bang, Yung-Jue|Kim, Tae-You
PMID: 19755509
Journal: Molecules. 2009 Oct 26;14(11):4300-11.
Title: Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway.
Author: Kim, Sangmin|Choi, Min Gew|Lee, Hye Sook|Lee, Se Kyung|Kim, Sung Hoon|Kim, Wan Wook|Hur, Sung Mo|Kim, Jung-Han|Choe, Jun-Ho|Nam, Seok Jin|Yang, Jung-Hyun|Kim, Sung|Lee, Jeong Eon|Kim, Jee Soo
PMID: 19924065
Journal: Oncol Res. 2009;18(2-3):107-16.
Title: Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer.
Author: Lee, Kyung Hee|Kim, Jae-Ryong
PMID: 20066900
Journal: Biomed Pharmacother. 2010 Feb;64(2):133-9.
Title: Gene expression profile towards the prediction of patient survival of gastric cancer.
Author: Xu, Zhen-Yu|Chen, Jia-Shun|Shu, Yong-Qian
PMID: 20005068
Journal: Toxicology. 2010 Jul-Aug;274(1-3):27-33.
Title: gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line.
Author: Bi, Sheng|Liu, Jia-Ren|Li, Yang|Wang, Qi|Liu, Hui-Kun|Yan, Ya-Geng|Chen, Bing-Qing|Sun, Wen-Guang
PMID: 20452389
Journal: Biosci Biotechnol Biochem. 2010;74(5):1018-24. Epub 2010 May 7.
Title: Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells.
Author: Sekiguchi, Hirotaka|Irie, Kazuhiro|Murakami, Akira
PMID: 20460732
Journal: Nat Med. 2010 Jul;16(7):793-8.
Title: Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.
Author: Palanisamy, Nallasivam|Ateeq, Bushra|Kalyana-Sundaram, Shanker|Pflueger, Dorothee|Ramnarayanan, Kalpana|Shankar, Sunita|Han, Bo|Cao, Qi|Cao, Xuhong|Suleman, Khalid|Kumar-Sinha, Chandan|Dhanasekaran, Saravana M|Chen, Ying-bei|Esgueva, Raquel|Banerjee, Samp
PMID: 20526349
Journal: FEMS Immunol Med Microbiol. 2011 Oct;63(1):82-92.
Title: Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration.
Author: Wang, Hongyan|Sun, Yundong|Liu, Shili|Yu, Han|Li, Wenjuan|Zeng, Jiping|Chen, Chunyan|Jia, Jihui
PMID: 21707777
Journal: Carcinogenesis. 2012 May;33(5):956-61.
Title: Oncogenic MAP2K1 mutations in human epithelial tumors.
Author: Choi, Young Lim|Soda, Manabu|Ueno, Toshihide|Hamada, Toru|Haruta, Hidenori|Yamato, Azusa|Fukumura, Kazutaka|Ando, Mizuo|Kawazu, Masahito|Yamashita, Yoshihiro|Mano, Hiroyuki
PMID: 22327936
Journal: Oncol Rep. 2012 Oct;28(4):1429-34.
Title: Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells.
Author: Lim, Sung-Chul|Duong, Hong-Quan|Parajuli, Keshab Raj|Han, Song Iy
PMID: 22824956
Journal: Yao Xue Xue Bao. 2012 Jun;47(6):816-21.
Title: [Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells].
Author: Wang, Hai-Bing|Ma, Xiao-Qiong
PMID: 22919733
Journal: Oncol Rep. 2012 Feb;27(2):553-8.
Title: Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.
Author: Wu, Yan|Chen, Yongchang|Qu, Rui|Lan, Ting|Sang, Jianrong
PMID: 22012247
Journal: PLoS One. 2013 Jul 18;8(7):e68999.
Title: Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population.
Author: Li, Wen-Qing|Hu, Nan|Wang, Zhaoming|Yu, Kai|Su, Hua|Wang, Lemin|Wang, Chaoyu|Chanock, Stephen J|Burdett, Laurie|Ding, Ti|Qiao, You-Lin|Fan, Jin-Hu|Wang, Yuan|Xu, Yi|Giffen, Carol|Xiong, Xiaoqin|Murphy, Gwen|Tucker, Margaret A|Dawsey, Sanford M|Freedman, N
PMID: 23874846
Journal: J Natl Cancer Inst. 2013 Nov 20;105(22):1738-49.
Title: Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness.
Author: Kong, Xuan|Qian, Jin|Chen, Li-Sha|Wang, Ying-Chao|Wang, Ji-Lin|Chen, Haoyan|Weng, Yu-Rong|Zhao, Shu-Liang|Hong, Jie|Chen, Ying-Xuan|Zou, Weiping|Xu, Jie|Fang, Jing-Yuan
PMID: 24104608
Journal: Int J Cancer. 2014 Feb 15;134(4):822-31.
Title: Genetic variants in fas signaling pathway genes and risk of gastric cancer.
Author: Hyland, Paula L|Lin, Shih-Wen|Hu, Nan|Zhang, Han|Wang, Lemin|Su, Hua|Wang, Chaoyu|Ding, Ti|Tang, Ze-Zhong|Fan, Jin-Hu|Qiao, You-Lin|Xiong, Xiaoqin|Wheeler, William|Giffen, Carol|Yu, Kai|Yuenger, Jeff|Burdett, Laurie|Wang, Zhaoming|Chanock, Stephen J|Tucke
PMID: 23921907
Journal: Genes Chromosomes Cancer. 2014 Nov;53(11):883-94.
Title: Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Author: Qian, Ziliang|Zhu, Guanshan|Tang, Lili|Wang, Mei|Zhang, Lianhai|Fu, Jiangang|Huang, Chunlei|Fan, Shuqiong|Sun, Yun|Lv, Jing|Dong, Hua|Gao, Beirong|Su, Xinying|Yu, Dehua|Zang, Jie|Zhang, Xiaolin|Ji, Jiafu|Ji, Qunsheng
PMID: 24935174
Journal: Int J Oncol. 2014 Oct;45(4):1760-8.
Title: Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1/2, NF-kappaB, and AP-1 signaling pathways.
Author: Khoi, Pham Ngoc|Xia, Yong|Lian, Sen|Kim, Ho Dong|Kim, Do Hyun|Joo, Young Eun|Chay, Kee-Oh|Kim, Kyung Keun|Jung, Young Do
PMID: 25069788
Journal: Mol Cancer Ther. 2014 Dec;13(12):3098-106.
Title: MEK inhibitor for gastric cancer with MEK1 gene mutations.
Author: Sogabe, Shunsuke|Togashi, Yosuke|Kato, Hiroaki|Kogita, Akihiro|Mizukami, Takuro|Sakamoto, Yoichi|Banno, Eri|Terashima, Masato|Hayashi, Hidetoshi|de Velasco, Marco A|Sakai, Kazuko|Fujita, Yoshihiko|Tomida, Shuta|Yasuda, Takushi|Takeyama, Yoshifumi|Okuno, K
PMID: 25253779
Journal: Cell Commun Signal. 2014 Nov 15;12:69.
Title: An increase in integrin-linked kinase non-canonically confers NF-kappaB-mediated growth advantages to gastric cancer cells by activating ERK1/2.
Author: Tseng, Po-Chun|Chen, Chia-Ling|Shan, Yan-Shen|Chang, Wen-Teng|Liu, Hsiao-Sheng|Hong, Tse-Ming|Hsieh, Chia-Yuan|Lin, Sheng-Hsiang|Lin, Chiou-Feng
PMID: 25398317
Journal: Oncol Rep. 2015 Aug;34(2):1011-6.
Title: Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells.
Author: Lee, Wan-Sik|Kim, Nuri|Park, Young-Ran|Oh, Hyung-Hoon|Myung, Eun|Kim, Seung-Hun|Yu, Hyung-Min|Kim, Mi-Young|Oak, Chan-Young|Chung, Cho-Yun|Park, Hyung-Chul|Myung, Dae-Seong|Cho, Sung-Bum|Joo, Young-Eun
PMID: 26058661
Journal: Int J Oncol. 2015 Aug;47(2):499-505.
Title: EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition.
Author: Mizukami, Takuro|Togashi, Yosuke|Sogabe, Shunsuke|Banno, Eri|Terashima, Masato|De Velasco, Marco A|Sakai, Kazuko|Fujita, Yoshihiko|Tomida, Shuta|Nakajima, Takako Eguchi|Boku, Narikazu|Nishio, Kazuto
PMID: 26081723
Journal: Cancer Chemother Pharmacol. 2015 Feb;75(2):353-63.
Title: Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.
Author: Guo, Bingyu|Zhang, Tingting|Su, Jingyuan|Wang, Kaiwen|Li, Xiaoming
PMID: 25527205
Journal: J Virol. 2015 Nov 11;90(2):1129-38.
Title: Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Promotes EBV Reactivation through Activation of the p38 Mitogen-Activated Protein Kinase.
Author: Liu, XueQiao|Cohen, Jeffrey I
PMID: 26559845
Journal: Eur J Cancer Prev. 2016 Nov;25(6):490-9.
Title: Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest.
Author: Liu, Enli|Li, Jie|Shi, Shasha|Wang, Xiaojian|Liang, Taigang|Wu, Bowei|Li, Qingshan
PMID: 26656929
Journal: Scand J Gastroenterol. 2017 Jun - Jul;52(6-7):745-753.
Title: CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways.
Author: Shi, Ameng|Shi, Haitao|Dong, Lei|Xu, Shaoxian|Jia, Miao|Guo, Xiaoyan|Wang, Ting
PMID: 28281844
Journal: Gastroenterology. 2017 Aug;153(2):536-549.e26.
Title: Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers.
Author: Cho, Soo Young|Park, Jun Won|Liu, Yang|Park, Young Soo|Kim, Ju Hee|Yang, Hanna|Um, Hyejin|Ko, Woo Ri|Lee, Byung Il|Kwon, Sun Young|Ryu, Seung Wan|Kwon, Chae Hwa|Park, Do Youn|Lee, Jae-Hyuk|Lee, Sang Il|Song, Kyu Sang|Hur, Hoon|Han, Sang-Uk|Chang, Heekyung
PMID: 28522256
Journal: JAMA Oncol. 2017 Nov 1;3(11):1546-1553.
Title: Genomic Profiling of Small-Bowel Adenocarcinoma.
Author: Schrock, Alexa B|Devoe, Craig E|McWilliams, Robert|Sun, James|Aparicio, Thomas|Stephens, Philip J|Ross, Jeffrey S|Wilson, Richard|Miller, Vincent A|Ali, Siraj M|Overman, Michael J
PMID: 28617917
Journal: Oncogenesis. 2017 Jul 31;6(7):e368.
Title: MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2-ERK1/2 signaling pathway by upregulating GIT1.
Author: Zhao, L Y|Tong, D D|Xue, M|Ma, H L|Liu, S Y|Yang, J|Liu, Y X|Guo, B|Ni, L|Liu, L Y|Qin, Y N|Wang, L M|Zhao, X G|Huang, C
PMID: 28759023
Journal: Oncotarget. 2017 Oct 31;8(61):104216-104226.
Title: Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade.
Author: Deng, Ruyuan|Mo, Fengbo|Chang, Bowen|Zhang, Qi|Ran, Hui|Yang, Shuhua|Zhu, Zhiqiang|Hu, Lei|Su, Qing
PMID: 29262634
Journal: Front Cell Infect Microbiol. 2018 Jan 15;7:541.
Title: Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway.
Author: Gunawardhana, Niluka|Jang, Sungil|Choi, Yun Hui|Hong, Youngmin A|Jeon, Yeong-Eui|Kim, Aeryun|Su, Hanfu|Kim, Ji-Hye|Yoo, Yun-Jung|Merrell, D Scott|Kim, Jinmoon|Cha, Jeong-Heon
PMID: 29379775
Journal: Cancer Res. 2018 Jun 1;78(11):3041-3053.
Title: Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.
Author: Ji, Cheng-Dong|Wang, Yan-Xia|Xiang, Dong-Fang|Liu, Qiang|Zhou, Zhi-Hua|Qian, Feng|Yang, Lang|Ren, Yong|Cui, Wei|Xu, Sen-Lin|Zhao, Xi-Long|Zhang, Xia|Wang, Yan|Zhang, Peng|Wang, Ji-Ming|Cui, You-Hong|Bian, Xiu-Wu
PMID: 29549164
Journal: Cancer Med. 2018 Jun 4.
Title: Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer.
Author: Lim, Byungho|Kim, Hee-Jin|Heo, Haejeong|Huh, Nanhyung|Baek, Su-Jin|Kim, Jong-Hwan|Bae, Dong-Hyuck|Seo, Eun-Hye|Lee, Sang-Il|Song, Kyu-Sang|Kim, Seon-Young|Kim, Yong Sung|Kim, Mirang
PMID: 29862663
Journal: Int J Biochem Cell Biol. 2018 Sep;102:128-137.
Title: Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor.
Author: Lee, Suk-Young|Na, Yoo Jin|Jeong, Yoon A|Kim, Jung Lim|Oh, Sang Cheul|Lee, Dae-Hee
PMID: 30044964