Primary Site >> Stomach Cancer
Gene >> MAP2K1
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Ref: Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells. PMID: 9341140 |
Ref: Activation of human histidine decarboxylase gene promoter activity by gastrin is mediated by two distinct nuclear factors. PMID: 10409643 |
Ref: Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade. PMID: 11719466 |
Ref: Extracellular signal-regulated protein kinases mediate H(+),K(+)-ATPase alpha-subunit gene expression. PMID: 11812003 Ref: Helicobacter pylori activates the proto-oncogene c-fos through SRE transactivation. PMID: 11866445 |
Ref: Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. PMID: 12509426 Ref: Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. PMID: 12907645 |
Ref: Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells. PMID: 15208668 |
Ref: Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer. PMID: 15655810 Ref: Extracellular signal-regulated kinase and AP-1 pathways are involved in reactive oxygen species-induced urokinase plasminogen activator receptor expression in human gastric cancer cells. PMID: 15870884 Ref: Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis. PMID: 16086234 |
Ref: Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation. PMID: 16395716 Ref: Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines. PMID: 16520550 Ref: Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells. PMID: 16627221 |
Ref: Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways. PMID: 17332476 |
Ref: p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR. PMID: 18347140 Ref: EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells. PMID: 19020743 |
Ref: Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. PMID: 19142899 Ref: Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. PMID: 19755509 Ref: Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway. PMID: 19924065 Ref: Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer. PMID: 20066900 |
Ref: Gene expression profile towards the prediction of patient survival of gastric cancer. PMID: 20005068 Ref: gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line. PMID: 20452389 Ref: Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells. PMID: 20460732 Ref: Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. PMID: 20526349 |
Ref: Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration. PMID: 21707777 |
Ref: Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells. PMID: 22012247 Ref: Oncogenic MAP2K1 mutations in human epithelial tumors. PMID: 22327936 Ref: Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells. PMID: 22824956 Ref: [Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells]. PMID: 22919733 |
Ref: Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population. PMID: 23874846 Ref: Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. PMID: 24104608 |
Ref: Genetic variants in fas signaling pathway genes and risk of gastric cancer. PMID: 23921907 Ref: Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets. PMID: 24935174 Ref: Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1/2, NF-kappaB, and AP-1 signaling pathways. PMID: 25069788 Ref: MEK inhibitor for gastric cancer with MEK1 gene mutations. PMID: 25253779 Ref: An increase in integrin-linked kinase non-canonically confers NF-kappaB-mediated growth advantages to gastric cancer cells by activating ERK1/2. PMID: 25398317 |
Ref: Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells. PMID: 25527205 Ref: Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells. PMID: 26058661 Ref: EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition. PMID: 26081723 |
Ref: Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Promotes EBV Reactivation through Activation of the p38 Mitogen-Activated Protein Kinase. PMID: 26559845 Ref: Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest. PMID: 26656929 |
Ref: CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways. PMID: 28281844 Ref: Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers. PMID: 28522256 Ref: Genomic Profiling of Small-Bowel Adenocarcinoma. PMID: 28617917 Ref: MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2-ERK1/2 signaling pathway by upregulating GIT1. PMID: 28759023 Ref: Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade. PMID: 29262634 Ref: Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway. PMID: 29379775 |
Ref: Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling. PMID: 29549164 Ref: Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer. PMID: 29862663 Ref: Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor. PMID: 30044964 |