Primary Site >> Liver Cancer

Gene >> LOX

Journal: Gastroenterology. 2007 Jun;132(7):2489-503.
Title: Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro.
Author: Geisler, Fabian|Algul, Hana|Paxian, Stephan|Schmid, Roland M
PMID: 17570221
Journal: Neoplasia. 2010 Feb;12(2):103-15.
Title: A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Author: Wang, Qi|Zhang, Weiying|Liu, Qiang|Zhang, Xuan|Lv, Na|Ye, Lihong|Zhang, Xiaodong
PMID: 20126469
Journal: Cell Res. 2010 May;20(5):563-75.
Title: Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2.
Author: Shan, Changliang|Xu, Fuqing|Zhang, Shuai|You, Jiacong|You, Xiaona|Qiu, Liyan|Zheng, Jie|Ye, Lihong|Zhang, Xiaodong
PMID: 20386571
Journal: Korean J Physiol Pharmacol. 2010 Oct;14(5):331-6.
Title: CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1alpha in Hepatoma Cells.
Author: Lee, Kyoung-Hwa
PMID: 21165333
Journal: Med Chem. 2011 Sep;7(5):432-42.
Title: Chebulagic acid synergizes the cytotoxicity of doxorubicin in human hepatocellular carcinoma through COX-2 dependant modulation of MDR-1.
Author: Achari, Chandrani|Reddy, Gorla V|Reddy, T C M|Reddanna, Pallu
PMID: 21801152
Journal: Mol Med Rep. 2011 Nov-Dec;4(6):1195-200.
Title: 5-Lipoxygenase contributes to the progression of hepatocellular carcinoma.
Author: Xu, Xi-Ming|Deng, Jun-Jian|Yuan, Guang-Jin|Yang, Fang|Guo, Hong-Ting|Xiang, Miao|Ge, Wei|Wu, Yao-Gui
PMID: 21833474
Journal: Mol Carcinog. 2012 Jun;51(6):439-48.
Title: Liver-specific overexpression of matrix metalloproteinase 9 (MMP-9) in transgenic mice accelerates development of hepatocellular carcinoma.
Author: Thieringer, Florian R|Maass, Thorsten|Anthon, Bianca|Meyer, Erik|Schirmacher, Peter|Longerich, Thomas|Galle, Peter R|Kanzler, Stephan|Teufel, Andreas
PMID: 21681821
Journal: Biochem Biophys Res Commun. 2012 Feb 24;418(4):647-51.
Title: Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-kappaB in hepatoma cells.
Author: Zhao, Yu|Wang, Wenhui|Wang, Qi|Zhang, Xiaodong|Ye, Lihong
PMID: 22293202
Journal: PLoS One. 2012;7(2):e31458.
Title: Hepatitis B virus X protein drives multiple cross-talk cascade loops involving NF-kappaB, 5-LOX, OPN and Capn4 to promote cell migration.
Author: Zhang, Xuan|You, Xiaona|Wang, Qi|Zhang, Tao|Du, Yumei|Lv, Na|Zhang, Zhao|Zhang, Shuai|Shan, Changliang|Ye, Lihong|Zhang, Xiaodong
PMID: 22355367
Journal: J Hepatol. 2012 Nov;57(5):1029-36.
Title: The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis.
Author: Nouet, Yann|Dahan, Jennifer|Labalette, Charlotte|Levillayer, Florence|Julien, Boris|Jouvion, Gregory|Cairo, Stefano|Vives, Francina Langa|Ribeiro, Agnes|Huerre, Michel|Colnot, Sabine|Perret, Christine|Nhieu, Jeanne Tran Van|Tordjmann, Thierry|Buendia, Mar
PMID: 22796152
Journal: PLoS One. 2012;7(7):e40794.
Title: The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
Author: Orlando, Ulises D|Garona, Juan|Ripoll, Giselle V|Maloberti, Paula M|Solano, Angela R|Avagnina, Alejandra|Gomez, Daniel E|Alonso, Daniel F|Podesta, Ernesto J
PMID: 22808264
Journal: Carcinogenesis. 2013 Jul;34(7):1644-52.
Title: Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.
Author: You, Xiaona|Liu, Fabao|Zhang, Tao|Li, Yinghui|Ye, Lihong|Zhang, Xiaodong
PMID: 23471881
Journal: Future Oncol. 2013 Jul;9(7):1029-37.
Title: Coevolution of the tumor microenvironment revealed by quantum dot-based multiplexed imaging of hepatocellular carcinoma.
Author: Fang, Min|Peng, Chun-Wei|Yuan, Jing-Ping|Zhang, Zhi-Ling|Pang, Dai-Wen|Li, Yan
PMID: 23837765
Journal: J Agric Food Chem. 2013 May 8;61(18):4326-35.
Title: Long-term ethanol exposure-induced hepatocellular carcinoma cell migration and invasion through lysyl oxidase activation are attenuated by combined treatment with pterostilbene and curcumin analogues.
Author: Huang, Ching-Shui|Ho, Chi-Tang|Tu, Shih-Hsin|Pan, Min-Hsiung|Chuang, Chien-Hui|Chang, Hui-Wen|Chang, Chien-Hsi|Wu, Chih-Hsiung|Ho, Yuan-Soon
PMID: 23560895
Journal: Biochem Biophys Res Commun. 2014 Feb 14;444(3):427-32.
Title: Increasing matrix stiffness upregulates vascular endothelial growth factor expression in hepatocellular carcinoma cells mediated by integrin beta1.
Author: Dong, Yinying|Xie, Xiaoying|Wang, Zhiming|Hu, Chao|Zheng, Qiongdan|Wang, Yaohui|Chen, Rongxin|Xue, Tongchun|Chen, Jie|Gao, Dongmei|Wu, Weizhong|Ren, Zhenggang|Cui, Jiefeng
PMID: 24472554
Journal: Oncol Rep. 2014 Apr;31(4):1669-76.
Title: Expression of the lysyl oxidase propeptide in hepatocellular carcinoma and its clinical relevance.
Author: Zheng, Ying|Wang, Xuemei|Wang, Haidong|Yan, Wei|Zhang, Quan|Chang, Xin
PMID: 24573150
Journal: Dig Dis Sci. 2015 Oct;60(10):3019-31.
Title: Lysyl Oxidase Is Predictive of Unfavorable Outcomes and Essential for Regulation of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma.
Author: Zhu, Jiye|Huang, Shan|Wu, Guobin|Huang, Chaoyuan|Li, Xianjian|Chen, Zhigang|Zhao, Lei|Zhao, Yinnong
PMID: 26048020
Journal: PLoS One. 2015 Aug 17;10(8):e0134243.
Title: Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin beta1/GSK3beta/beta-Catenin Signaling Pathway.
Author: You, Yang|Zheng, Qiongdan|Dong, Yinying|Wang, Yaohui|Zhang, Lan|Xue, Tongchun|Xie, Xiaoying|Hu, Chao|Wang, Zhiming|Chen, Rongxin|Wang, Yanhong|Cui, Jiefeng|Ren, Zhenggang
PMID: 26280346
Journal:
Title: Roles of E-cadherin in Hepatocarcinogenesis
Author: Maeda, Shin|Nakagawa, Hayato
PMID: 29787164
Journal: Gut. 2016 Jun;65(6):1024-34.
Title: Antitumour activity of an inhibitor of miR-34a in liver cancer with beta-catenin-mutations.
Author: Gougelet, Angelique|Sartor, Chiara|Bachelot, Laura|Godard, Cecile|Marchiol, Carmen|Renault, Gilles|Tores, Frederic|Nitschke, Patrick|Cavard, Catherine|Terris, Benoit|Perret, Christine|Colnot, Sabine
PMID: 25792709
Journal: PLoS One. 2017 Apr 19;12(4):e0173376.
Title: Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice.
Author: Lytle, Kelli A|Wong, Carmen P|Jump, Donald B
PMID: 28422962
Journal: Curr Pharm Biotechnol. 2018;19(1):43-67.
Title: Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review.
Author: Tabassum, Heena|Ahmad, Asad|Ahmad, Iffat Z
PMID: 29701149