Primary Site >> Stomach Cancer

Gene >> LGR5

Journal: Curr Mol Med. 2009 Sep;9(7):873-86.
Title: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Author: Katoh, Y|Katoh, M
PMID: 19860666
Journal: J Surg Res. 2011 Nov;171(1):6-14.
Title: Murine tissue-engineered stomach demonstrates epithelial differentiation.
Author: Speer, Allison L|Sala, Frederic G|Matthews, Jamil A|Grikscheit, Tracy C
PMID: 21571313
Journal: J Gastroenterol. 2011 Jul;46(7):855-65.
Title: Current molecular markers for gastric progenitor cells and gastric cancer stem cells.
Author: Qiao, Xiaotan T|Gumucio, Deborah L
PMID: 21626457
Journal: Gut. 2012 Dec;61(12):1678-85.
Title: Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells.
Author: Nam, Ki Taek|O'Neal, Ryan L|Coffey, Robert J|Finke, Paul E|Barker, Nick|Goldenring, James R
PMID: 22198711
Journal: PLoS One. 2012;7(4):e35486.
Title: The spatial distribution of LGR5+ cells correlates with gastric cancer progression.
Author: Simon, Eva|Petke, Diana|Boger, Christine|Behrens, Hans-Michael|Warneke, Viktoria|Ebert, Matthias|Rocken, Christoph
PMID: 22530031
Journal: PLoS One. 2012;7(9):e44566.
Title: Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and beta-catenin gene signature predicts survival.
Author: Bauer, Lukas|Langer, Rupert|Becker, Karen|Hapfelmeier, Alexander|Ott, Katja|Novotny, Alexander|Hofler, Heinz|Keller, Gisela
PMID: 22970250
Journal: Pathologe. 2012 Nov;33 Suppl 2:235-40.
Title: [Molecular pathology of gastric cancer].
Author: Rocken, C|Warneke, V
PMID: 22983100
Journal: Gut Pathog. 2012 Dec 8;4(1):18.
Title: Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges.
Author: Ding, Song-Ze|Zheng, Peng-Yuan
PMID: 23217022
Journal: Dig Dis Sci. 2013 Jan;58(1):140-9.
Title: H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer.
Author: Uehara, Takeshi|Ma, Deqin|Yao, Yuan|Lynch, John P|Morales, Knashawn|Ziober, Amy|Feldman, Michael|Ota, Hiroyoshi|Sepulveda, Antonia R
PMID: 22945475
Journal: World J Gastroenterol. 2013 Dec 14;19(46):8714-21.
Title: Intestinal stem cell marker LGR5 expression during gastric carcinogenesis.
Author: Zheng, Zhi-Xue|Sun, Yu|Bu, Zhao-De|Zhang, Lian-Hai|Li, Zi-Yu|Wu, Ai-Wen|Wu, Xiao-Jiang|Wang, Xiao-Hong|Cheng, Xiao-Jing|Xing, Xiao-Fang|Du, Hong|Ji, Jia-Fu
PMID: 24379591
Journal: PLoS One. 2013 Dec 10;8(12):e82390.
Title: Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis.
Author: Jang, Bo Gun|Lee, Byung Lan|Kim, Woo Ho
PMID: 24340024
Journal: J Gastrointest Cancer. 2013 Dec;44(4):428-35.
Title: Cancer stem cells biomarkers in gastric carcinogenesis.
Author: Yang, Liu|Levi, Edi|Zhu, Shunshi|Du, Jianhua|Majumdar, Adhip P N
PMID: 23949555
Journal: Pathologe. 2013 Sep;34(5):403-12.
Title: [Ways to personalized medicine for gastric cancer].
Author: Rocken, C
PMID: 23907566
Journal: Chin J Cancer Res. 2013 Feb;25(1):79-89.
Title: LGR5 is a promising biomarker for patients with stage I and II gastric cancer.
Author: Bu, Zhaode|Zheng, Zhixue|Zhang, Lianhai|Li, Ziyu|Sun, Yu|Dong, Bin|Wu, Aiwen|Wu, Xiaojiang|Wang, Xiaohong|Cheng, Xiaojing|Xing, Xiaofang|Li, Yingai|Du, Hong|Ji, Jiafu
PMID: 23372345
Journal: Pathol Int. 2013 Jan;63(1):13-9.
Title: Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer.
Author: Yamanoi, Kazuhiro|Fukuma, Mariko|Uchida, Hiroshi|Kushima, Ryoji|Yamazaki, Ken|Katai, Hitoshi|Kanai, Yae|Sakamoto, Michiie
PMID: 23356221
Journal: Oncol Rep. 2014 Jul;32(1):181-8.
Title: Increased expression of Lgr5 is associated with chemotherapy resistance in human gastric cancer.
Author: Xi, Hong-Qing|Cui, Jian-Xin|Shen, Wei-Song|Wu, Xiao-Song|Bian, Shi-Bo|Li, Ji-Yang|Song, Zhou|Wei, Bo|Chen, Lin
PMID: 24859092
Journal: Nature. 2014 Dec 18;516(7531):400-4.
Title: Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.
Author: McCracken, Kyle W|Cata, Emily M|Crawford, Calyn M|Sinagoga, Katie L|Schumacher, Michael|Rockich, Briana E|Tsai, Yu-Hwai|Mayhew, Christopher N|Spence, Jason R|Zavros, Yana|Wells, James M
PMID: 25363776
Journal: Br J Cancer. 2014 Apr 15;110(8):2011-20.
Title: Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer.
Author: Xi, H Q|Cai, A Z|Wu, X S|Cui, J X|Shen, W S|Bian, S B|Wang, N|Li, J Y|Lu, C R|Song, Z|Wei, B|Chen, L
PMID: 24594994
Journal: Gut. 2015 Apr;64(4):544-53.
Title: CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.
Author: Hayakawa, Yoku|Jin, Guangchun|Wang, Hongshan|Chen, Xiaowei|Westphalen, Christoph B|Asfaha, Samuel|Renz, Bernhard W|Ariyama, Hiroshi|Dubeykovskaya, Zinaida A|Takemoto, Yoshihiro|Lee, Yoomi|Muley, Ashlesha|Tailor, Yagnesh|Chen, Duan|Muthupalani, Sureshkumar
PMID: 24951258
Journal: World J Gastroenterol. 2015 Jan 7;21(1):112-23.
Title: Stem cells in gastric cancer.
Author: Zhao, Yue|Feng, Fei|Zhou, Yong-Ning
PMID: 25574084
Journal: Gastroenterology. 2015 Jun;148(7):1392-404.e21.
Title: Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands.
Author: Sigal, Michael|Rothenberg, Michael E|Logan, Catriona Y|Lee, Josephine Y|Honaker, Ryan W|Cooper, Rachel L|Passarelli, Ben|Camorlinga, Margarita|Bouley, Donna M|Alvarez, Guillermo|Nusse, Roeland|Torres, Javier|Amieva, Manuel R
PMID: 25725293
Journal: Panminerva Med. 2015 Dec;57(4):167-75. Epub 2015 Apr 29.
Title: ZnRF3 induces apoptosis of gastric cancer cells by antagonizing Wnt and Hedgehog signaling.
Author: Qin, H|Cai, A|Xi, H|Yuan, J|Chen, L
PMID: 25923840
Journal: Asian Pac J Cancer Prev. 2015;16(10):4177-83.
Title: Aberrant Expression of Markers of Cancer Stem Cells in Gastric Adenocarcinoma and their Relationship to Vasculogenic Mimicry.
Author: Zhou, Lei|Yu, Lan|Feng, Zhen-Zhong|Gong, Xiao-Meng|Cheng, Ze-Nong|Yao, Nan|Wang, Dan-Na|Wu, Shi-Wu
PMID: 26028069
Journal: Cell Physiol Biochem. 2015;36(5):1835-46.
Title: RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma.
Author: Niu, Lei|Qin, Hong-Zhen|Xi, Hong-Qing|Wei, Bo|Xia, Shao-You|Chen, Lin
PMID: 26184844
Journal: Cell Physiol Biochem. 2015;36(6):2447-55.
Title: Lgr5-Positive Cells are Cancer-Stem-Cell-Like Cells in Gastric Cancer.
Author: Wang, Zhongli|Liu, Chao
PMID: 26279446
Journal: Cell Biochem Biophys. 2015 Nov;73(2):361-367.
Title: ZnRF3 Induces Apoptosis of Gastric Cancer Cells by Antagonizing Wnt and Hedgehog Signaling.
Author: Qin, Hongzhen|Cai, Aizhen|Xi, Hongqing|Yuan, Jing|Chen, Lin
PMID: 27352324
Journal: Cancer Lett. 2016 May 1;374(2):292-303.
Title: Helicobacter pylori upregulates Nanog and Oct4 via Wnt/beta-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer.
Author: Yong, Xin|Tang, Bo|Xiao, Yu-Feng|Xie, Rui|Qin, Yong|Luo, Gang|Hu, Chang-Jiang|Dong, Hui|Yang, Shi-Ming
PMID: 26940070
Journal: PLoS One. 2016 Dec 29;11(12):e0168904.
Title: LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1.
Author: Wang, Bei|Chen, Queting|Cao, Yang|Ma, Xia|Yin, Chenxing|Jia, Youchao|Zang, Aimin|Fan, Wufang
PMID: 28033430
Journal: Oncol Rep. 2016 Dec;36(6):3207-3214.
Title: Proton pump inhibitor pantoprazole inhibits the proliferation, selfrenewal and chemoresistance of gastric cancer stem cells via the EMT/betacatenin pathways.
Author: Feng, Shuitu|Zheng, Zhigao|Feng, Lihua|Yang, Lihong|Chen, Zuhong|Lin, Yubiao|Gao, Yingqin|Chen, Yide
PMID: 27748935
Journal: Arch Biochem Biophys. 2016 Nov 15;610:16-24.
Title: High-fat diet feeding promotes stemness and precancerous changes in murine gastric mucosa mediated by leptin receptor signaling pathway.
Author: Arita, Seiya|Kinoshita, Yuta|Ushida, Kaori|Enomoto, Atsushi|Inagaki-Ohara, Kyoko
PMID: 27693038
Journal: Pathol Int. 2016 Sep;66(9):518-23.
Title: Distribution of Lgr5-positive cancer cells in intramucosal gastric signet-ring cell carcinoma.
Author: Nakajima, Tomoyuki|Uehara, Takeshi|Maruyama, Yasuhiro|Iwaya, Mai|Kobayashi, Yukihiro|Ota, Hiroyoshi
PMID: 27593551
Journal: Oncotarget. 2016 Sep 20;7(38):62049-62069.
Title: Clinical significance of putative markers of cancer stem cells in gastric cancer: A retrospective cohort study.
Author: Chen, Xiao-Long|Chen, Xin-Zu|Wang, Yi-Gao|He, Du|Lu, Zheng-Hao|Liu, Kai|Zhang, Wei-Han|Wang, Wei|Li, Chang-Chun|Xue, Lian|Zhao, Lin-Yong|Yang, Kun|Liu, Jian-Ping|Zhou, Zong-Guang|Hu, Jian-Kun|Mo, Xian-Ming
PMID: 27557490
Journal: Cell Death Dis. 2016 Jun 9;7(6):e2255.
Title: KLF4 deletion alters gastric cell lineage and induces MUC2 expression.
Author: Yu, T|Chen, X|Lin, T|Liu, J|Li, M|Zhang, W|Xu, X|Zhao, W|Liu, M|Napier, D L|Wang, C|Evers, B M|Liu, C
PMID: 27277677
Journal: Oncotarget. 2016 May 10;7(19):28670-83.
Title: A reciprocal regulatory circuit between CD44 and FGFR2 via c-myc controls gastric cancer cell growth.
Author: Park, Jihyun|Kim, Sun Young|Kim, Ha-Jung|Kim, Kyoung-Mee|Choi, Eun Young|Kang, Myung-Soo
PMID: 27107424
Journal: Oncotarget. 2016 Mar 1;7(9):10255-70.
Title: Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways.
Author: Syu, Li-Jyun|Zhao, Xinyi|Zhang, Yaqing|Grachtchouk, Marina|Demitrack, Elise|Ermilov, Alexandre|Wilbert, Dawn M|Zheng, Xinlei|Kaatz, Ashley|Greenson, Joel K|Gumucio, Deborah L|Merchant, Juanita L|di Magliano, Marina Pasca|Samuelson, Linda C|Dlugosz, Andrze
PMID: 26859571
Journal: Clin Res Hepatol Gastroenterol. 2016 Apr;40(2):246-53.
Title: The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis.
Author: Huang, Tianchen|Qiu, Xinguang|Xiao, Jianan|Wang, Qingbing|Wang, Yanjun|Zhang, Yong|Bai, Dongxiao
PMID: 26387842
Journal: Gastric Cancer. 2016 Jul;19(3):767-77.
Title: Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas.
Author: Jang, Bo Gun|Lee, Byung Lan|Kim, Woo Ho
PMID: 26386561
Journal: Anticancer Agents Med Chem. 2016;16(9):1079-84.
Title: Lgr5 Contributes to Intestinal Metaplasia During Gastric Carcinogenesis: A Meta analysis.
Author: Han, Ye|Zhi, Qiaoming|Xue, Xiaofeng|Yuan, Bin|Zhao, Hong|Kuang, Yuting|Zhang, Lifeng
PMID: 26077638
Journal: Oncotarget. 2016 Jun 14;7(24):36049-36064.
Title: Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer.
Author: Wang, Sophie Sw|Wuputra, Kenly|Liu, Chung-Jung|Lin, Yin-Chu|Chen, Yi-Ting|Chai, Chee-Yin|Lin, Chen-Lung Steve|Kuo, Kung-Kai|Tsai, Ming-Ho|Wang, Shin-Wei|Chen, Ker-Kong|Miyoshi, Hiroyuki|Nakamura, Yukio|Saito, Shigeo|Hanafusa, Tadashi|Wu, Deng-Chyang|Lin,
PMID: 27144338
Journal: Oncotarget. 2017 Jun 28;8(38):63382-63391.
Title: Identification of AQP3 and CD24 as biomarkers for carcinogenesis of gastric intestinal metaplasia.
Author: Zhao, Haijian|Wen, Jianfei|Dong, Xuqiang|He, Ruji|Gao, Cheng|Zhang, Weiming|Zhang, Zhihong|Shen, Lizong
PMID: 28968998
Journal: Oncotarget. 2017 Nov 10;8(67):111012-111025.
Title: CXCR4-expressing Mist1(+) progenitors in the gastric antrum contribute to gastric cancer development.
Author: Sakitani, Kosuke|Hayakawa, Yoku|Deng, Huan|Ariyama, Hiroshi|Kinoshita, Hiroto|Konishi, Mitsuru|Ono, Satoshi|Suzuki, Nobumi|Ihara, Sozaburo|Niu, Zhengchuan|Kim, Woosook|Tanaka, Takayuki|Liu, Haibo|Chen, Xiaowei|Tailor, Yagnesh|Fox, James G|Konieczny, Steph
PMID: 29340033
Journal: Appl Immunohistochem Mol Morphol. 2017 Oct 27.
Title: Personalizing Gastric Cancer Screening With Predictive Modeling of Disease Progression Biomarkers.
Author: Walker, Rachel|Mejia, Jaime|Lee, Jae K|Pimiento, Jose M|Malafa, Mokenge|Giuliano, Anna R|Coppola, Domenico|Enderling, Heiko
PMID: 29084052
Journal: Biochem Biophys Res Commun. 2017 Nov 25;493(3):1349-1355.
Title: FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells.
Author: Choi, Yiseul|Park, Jinju|Ko, Young San|Kim, Younghoon|Pyo, Jung-Soo|Jang, Bo Gun|Kim, Min A|Lee, Jae-Seon|Chang, Mee Soo|Lee, Byung Lan
PMID: 28970066
Journal: Cancer Biomark. 2017 Dec 6;20(4):563-573.
Title: Lgr5High/DCLK1High phenotype is more common in early stage and intestinal subtypes of gastric carcinomas.
Author: Kalantari, Elham|Asadi Lari, Mohammad Hossein|Roudi, Raheleh|Korourian, Alireza|Madjd, Zahra
PMID: 28946555
Journal: Gastrointest Tumors. 2017 Mar;3(3-4):115-124.
Title: Clinicopathology of Early Gastric Carcinoma: An Update for Pathologists and Gastroenterologists.
Author: Huang, Qin|Zou, Xiaoping
PMID: 28611977
Journal: Nat Cell Biol. 2017 Jul;19(7):774-786.
Title: Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach.
Author: Leushacke, Marc|Tan, Si Hui|Wong, Angeline|Swathi, Yada|Hajamohideen, Amin|Tan, Liang Thing|Goh, Jasmine|Wong, Esther|Denil, Simon L I J|Murakami, Kazuhiro|Barker, Nick
PMID: 28581476
Journal: Stem Cell Res Ther. 2017 Apr 26;8(1):98.
Title: Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-beta/catenin signaling pathway.
Author: Gao, Yunhe|Cai, Aizhen|Xi, Hongqing|Li, Jiyang|Xu, Wei|Zhang, Yanmei|Zhang, Kecheng|Cui, Jianxin|Wu, Xiaosong|Wei, Bo|Chen, Lin
PMID: 28446252
Journal: Oncotarget. 2017 May 9;8(19):31581-31591.
Title: RNAi-mediated inhibition of Lgr5 leads to decreased angiogenesis in gastric cancer.
Author: Xi, Hong-Qing|Zhang, Ke-Cheng|Li, Ji-Yang|Cui, Jian-Xin|Gao, Yun-He|Wei, Bo|Huang, Dongsheng|Chen, Lin
PMID: 28404940
Journal: Mol Carcinog. 2017 Sep;56(9):2022-2034.
Title: Upregulated miR-132 in Lgr5(+) gastric cancer stem cell-like cells contributes to cisplatin-resistance via SIRT1/CREB/ABCG2 signaling pathway.
Author: Zhang, Lanfang|Guo, Xiaohe|Zhang, Dezhong|Fan, Yingying|Qin, Lei|Dong, Shuping|Zhang, Lanfang
PMID: 28383763
Journal: Mol Cancer Res. 2017 Jun;15(6):776-785.
Title: Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1.
Author: Wilhelm, Franziska|Simon, Eva|Boger, Christine|Behrens, Hans-Michael|Kruger, Sandra|Rocken, Christoph
PMID: 28219935
Journal: Gastric Cancer. 2018 Mar;21(2):196-203.
Title: Toward early detection of Helicobacter pylori-associated gastric cancer.
Author: Walker, Rachel|Poleszczuk, Jan|Mejia, Jaime|Lee, Jae K|Pimiento, Jose M|Malafa, Mokenge|Giuliano, Anna R|Enderling, Heiko|Coppola, Domenico
PMID: 28725964
Journal: Stem Cells. 2018 Mar 31.
Title: PGD2/PTGDR2 Signaling Restricts the Self-Renewal and Tumorigenesis of Gastric Cancer.
Author: Zhang, Bin|Bie, Qingli|Wu, Peipei|Zhang, Jie|You, Benshuai|Shi, Hui|Qian, Hui|Xu, Wenrong
PMID: 29604141
Journal: PLoS One. 2018 Apr 24;13(4):e0192436.
Title: NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells.
Author: Ma, Xia|Wang, Bei|Wang, Xiaofang|Luo, Yujiao|Fan, Wufang
PMID: 29689047
Journal: Int J Mol Med. 2018 Aug;42(2):713-725.
Title: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author: Katoh, Masaru
PMID: 29786110
Journal: Mol Med Rep. 2018 Aug;18(2):2269-2276.
Title: LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR4310/LGR5/Wnt/betacatenin signaling pathway.
Author: Jing, Niancai|Huang, Tao|Guo, Huaiyu|Yang, Jili|Li, Mingjing|Chen, Zhuo|Zhang, Yue
PMID: 29956772
Journal: Am J Chin Med. 2018;46(5):1129-1143.
Title: Effects of Celastrus orbiculatus on Epithelial Mesenchymal Transition in Gastric Mucosal Epithelial Cells by Inhibiting Lgr5 Expression from Rats with Gastric Precancerous Lesions.
Author: Zhu, Yao-Dong|Hu, Lei|Li, Ping|Zhang, Mei|Liu, Yan-Qing
PMID: 29976080
Journal: J Exp Clin Cancer Res. 2018 Sep 12;37(1):225.
Title: LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/beta-catenin pathway and predicts poor survival of glioma patients.
Author: Zhang, Jin|Cai, Hongqing|Sun, Lixin|Zhan, Panpan|Chen, Meng|Zhang, Feng|Ran, Yuliang|Wan, Jinghai
PMID: 30208924
Journal: Oncol Lett. 2018 Oct;16(4):5426-5432.
Title: Dipeptide gamma-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties.
Author: Kato, Ryo|Iwamuro, Masaya|Shiraha, Hidenori|Horiguchi, Shigeru|Tanaka, Emi|Matsumoto, Ken|Ohyama, Atsushi|Sawahara, Hiroaki|Nagahara, Teruya|Uchida, Daisuke|Tsutsumi, Koichiro|Okada, Hiroyuki
PMID: 30250614
Journal: J Cell Biochem. 2018 Oct 26.
Title: RSPO2 enhances cell invasion and migration via the WNT/beta-catenin pathway in human gastric cancer.
Author: Zhang, Haibo|Han, Xiaoyan|Wei, Bo|Fang, Jiafeng|Hou, Xuerui|Lan, Tianyun|Wei, Hongbo
PMID: 30362605
Journal: Stem Cells. 2018 Oct 31.
Title: Reciprocal reprogramming of cancer cells and associated Mesenchymal Stem Cells in gastric cancer.
Author: Shamai, Yeela|Alperovich, Dalia Cohn|Yakhini, Zohar|Skorecki, Karl|Tzukerman, Maty
PMID: 30379370