Primary Site >> Stomach Cancer
Gene >> LGR5
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Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 |
Ref: Murine tissue-engineered stomach demonstrates epithelial differentiation. PMID: 21571313 Ref: Current molecular markers for gastric progenitor cells and gastric cancer stem cells. PMID: 21626457 |
Ref: Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. PMID: 22198711 Ref: The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PMID: 22530031 Ref: Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and beta-catenin gene signature predicts survival. PMID: 22970250 Ref: [Molecular pathology of gastric cancer]. PMID: 22983100 Ref: Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges. PMID: 23217022 |
Ref: H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer. PMID: 22945475 Ref: Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer. PMID: 23356221 Ref: LGR5 is a promising biomarker for patients with stage I and II gastric cancer. PMID: 23372345 Ref: [Ways to personalized medicine for gastric cancer]. PMID: 23907566 Ref: Cancer stem cells biomarkers in gastric carcinogenesis. PMID: 23949555 Ref: Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis. PMID: 24340024 Ref: Intestinal stem cell marker LGR5 expression during gastric carcinogenesis. PMID: 24379591 |
Ref: Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer. PMID: 24594994 Ref: Increased expression of Lgr5 is associated with chemotherapy resistance in human gastric cancer. PMID: 24859092 Ref: Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. PMID: 25363776 |
Ref: CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis. PMID: 24951258 Ref: Stem cells in gastric cancer. PMID: 25574084 Ref: Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands. PMID: 25725293 Ref: ZnRF3 induces apoptosis of gastric cancer cells by antagonizing Wnt and Hedgehog signaling. PMID: 25923840 Ref: Aberrant Expression of Markers of Cancer Stem Cells in Gastric Adenocarcinoma and their Relationship to Vasculogenic Mimicry. PMID: 26028069 Ref: RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma. PMID: 26184844 Ref: Lgr5-Positive Cells are Cancer-Stem-Cell-Like Cells in Gastric Cancer. PMID: 26279446 Ref: ZnRF3 Induces Apoptosis of Gastric Cancer Cells by Antagonizing Wnt and Hedgehog Signaling. PMID: 27352324 |
Ref: Lgr5 Contributes to Intestinal Metaplasia During Gastric Carcinogenesis: A Meta analysis. PMID: 26077638 Ref: Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas. PMID: 26386561 Ref: The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis. PMID: 26387842 Ref: Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways. PMID: 26859571 Ref: Helicobacter pylori upregulates Nanog and Oct4 via Wnt/beta-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. PMID: 26940070 Ref: A reciprocal regulatory circuit between CD44 and FGFR2 via c-myc controls gastric cancer cell growth. PMID: 27107424 Ref: Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer. PMID: 27144338 Ref: KLF4 deletion alters gastric cell lineage and induces MUC2 expression. PMID: 27277677 Ref: Clinical significance of putative markers of cancer stem cells in gastric cancer: A retrospective cohort study. PMID: 27557490 Ref: Distribution of Lgr5-positive cancer cells in intramucosal gastric signet-ring cell carcinoma. PMID: 27593551 Ref: High-fat diet feeding promotes stemness and precancerous changes in murine gastric mucosa mediated by leptin receptor signaling pathway. PMID: 27693038 Ref: Proton pump inhibitor pantoprazole inhibits the proliferation, selfrenewal and chemoresistance of gastric cancer stem cells via the EMT/betacatenin pathways. PMID: 27748935 Ref: LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1. PMID: 28033430 |
Ref: Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1. PMID: 28219935 Ref: Upregulated miR-132 in Lgr5(+) gastric cancer stem cell-like cells contributes to cisplatin-resistance via SIRT1/CREB/ABCG2 signaling pathway. PMID: 28383763 Ref: RNAi-mediated inhibition of Lgr5 leads to decreased angiogenesis in gastric cancer. PMID: 28404940 Ref: Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-beta/catenin signaling pathway. PMID: 28446252 Ref: Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach. PMID: 28581476 Ref: Clinicopathology of Early Gastric Carcinoma: An Update for Pathologists and Gastroenterologists. PMID: 28611977 Ref: Lgr5High/DCLK1High phenotype is more common in early stage and intestinal subtypes of gastric carcinomas. PMID: 28946555 Ref: Identification of AQP3 and CD24 as biomarkers for carcinogenesis of gastric intestinal metaplasia. PMID: 28968998 Ref: FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells. PMID: 28970066 Ref: Personalizing Gastric Cancer Screening With Predictive Modeling of Disease Progression Biomarkers. PMID: 29084052 Ref: CXCR4-expressing Mist1(+) progenitors in the gastric antrum contribute to gastric cancer development. PMID: 29340033 |
Ref: Toward early detection of Helicobacter pylori-associated gastric cancer. PMID: 28725964 Ref: PGD2/PTGDR2 Signaling Restricts the Self-Renewal and Tumorigenesis of Gastric Cancer. PMID: 29604141 Ref: NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells. PMID: 29689047 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR4310/LGR5/Wnt/betacatenin signaling pathway. PMID: 29956772 Ref: Effects of Celastrus orbiculatus on Epithelial Mesenchymal Transition in Gastric Mucosal Epithelial Cells by Inhibiting Lgr5 Expression from Rats with Gastric Precancerous Lesions. PMID: 29976080 Ref: LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/beta-catenin pathway and predicts poor survival of glioma patients. PMID: 30208924 Ref: Dipeptide gamma-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties. PMID: 30250614 Ref: RSPO2 enhances cell invasion and migration via the WNT/beta-catenin pathway in human gastric cancer. PMID: 30362605 Ref: Reciprocal reprogramming of cancer cells and associated Mesenchymal Stem Cells in gastric cancer. PMID: 30379370 |