Primary Site >> Stomach Cancer

Gene >> KLF4

Journal: J Biol Chem. 2004 Mar 5;279(10):8684-93. Epub 2003 Dec 10.
Title: Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements.
Author: Ai, Wandong|Liu, Ying|Langlois, Michael|Wang, Timothy C
PMID: 14670968
Journal: Carcinogenesis. 2005 Jun;26(6):1129-37. Epub 2005 Mar 10.
Title: Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.
Author: Kang, Weiqun|Nielsen, Ole|Fenger, Claus|Leslie, Graham|Holmskov, Uffe|Reid, Kenneth B M
PMID: 15760920
Journal: Gastroenterology. 2005 Apr;128(4):935-45.
Title: Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.
Author: Katz, Jonathan P|Perreault, Nathalie|Goldstein, Bree G|Actman, Lori|McNally, Sara R|Silberg, Debra G|Furth, Emma E|Kaestner, Klaus H
PMID: 15825076
Journal: Cancer Res. 2005 Apr 1;65(7):2746-54.
Title: Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression.
Author: Wei, Daoyan|Gong, Weida|Kanai, Masashi|Schlunk, Christian|Wang, Liwei|Yao, James C|Wu, Tsung-Teh|Huang, Suyun|Xie, Keping
PMID: 15805274
Journal: Carcinogenesis. 2006 Jan;27(1):23-31.
Title: Emerging role of KLF4 in human gastrointestinal cancer.
Author: Wei, Daoyan|Kanai, Masashi|Huang, Suyun|Xie, Keping
PMID: 16219632
Journal: Clin Cancer Res. 2006 Nov 1;12(21):6395-402.
Title: Loss of Kruppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression.
Author: Kanai, Masashi|Wei, Daoyan|Li, Qiang|Jia, Zhiliang|Ajani, Jaffer|Le, Xiangdong|Yao, James|Xie, Keping
PMID: 17085651
Journal: Blood. 2007 Jan 15;109(2):747-55. Epub 2006 Sep 5.
Title: KLF4 suppresses transformation of pre-B cells by ABL oncogenes.
Author: Kharas, Michael G|Yusuf, Isharat|Scarfone, Vanessa M|Yang, Vincent W|Segre, Julia A|Huettner, Claudia S|Fruman, David A
PMID: 16954505
Journal: Int J Oncol. 2007 Mar;30(3):751-5.
Title: Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.
Author: Katoh, Yuriko|Katoh, Masaru
PMID: 17273778
Journal: APMIS. 2007 Jul;115(7):802-8.
Title: Genetic and epigenetic analysis of the KLF4 gene in gastric cancer.
Author: Cho, Yong Gu|Song, Jae Hwi|Kim, Chang Jae|Nam, Suk Woo|Yoo, Nam Jin|Lee, Jung Young|Park, Won Sang
PMID: 17614846
Journal: Biochem J. 2009 May 27;420(3):403-11.
Title: KLF4 positively regulates human ghrelin expression.
Author: Lee, Hyo Jung|Kang, Young Mi|Moon, Chang Suk|Joe, Myung Kuk|Lim, Joo Hyun|Suh, Young Ho|Song, Jihyun|Jung, Myeong Ho
PMID: 19327128
Journal: Clin Cancer Res. 2009 Sep 15;15(18):5688-95.
Title: Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma.
Author: Hu, Wenxian|Hofstetter, Wayne L|Li, Hong|Zhou, Yanbin|He, Yong|Pataer, Abujiang|Wang, Li|Xie, Keping|Swisher, Stephen G|Fang, Bingliang
PMID: 19737957
Journal: Int J Oncol. 2010 Feb;36(2):405-14.
Title: An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer.
Author: Zhang, Xianglan|Yang, Jung-Jin|Kim, Yoon Sun|Kim, Ki-Yeol|Ahn, Woong Shick|Yang, Sanghwa
PMID: 20043075
Journal: Am J Pathol. 2010 Dec;177(6):2701-7.
Title: Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of Kruppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation.
Author: Ganguly, Subhalakshmi|Basu, Biswarup|Shome, Saurav|Jadhav, Tushar|Roy, Sudipta|Majumdar, Jahar|Dasgupta, Partha Sarathi|Basu, Sujit
PMID: 21075859
Journal: Gastroenterology. 2012 Mar;142(3):531-42.
Title: Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.
Author: Li, Qiang|Jia, Zhiliang|Wang, Li|Kong, Xiangyu|Li, Qi|Guo, Kun|Tan, Dongfeng|Le, Xiangdong|Wei, Daoyan|Huang, Suyun|Mishra, Lopa|Xie, Keping
PMID: 22155367
Journal: Int J Oncol. 2012 Jun;40(6):2038-48.
Title: Kruppel-like factor 4 negatively regulates beta-catenin expression and inhibits the proliferation, invasion and metastasis of gastric cancer.
Author: Zhang, Neng|Zhang, Jun|Shuai, Leiyuan|Zha, Lang|He, Miao|Huang, Zhen|Wang, Ziwei
PMID: 22407433
Journal: Oncol Lett. 2012 May;3(5):1017-1022.
Title: Altered expression of Kruppel-like factor 4 and beta-catenin in human gastric cancer.
Author: Zhang, N|Zhang, J|Wang, Z W|Zha, L|Huang, Z
PMID: 22783383
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Jul;15(7):732-5.
Title: [Association between gut-enriched Kruppel-like factor and prognosis of patients with gastric cancer].
Author: Li, Ming-xue|Wang, Quan|Wang, Bin|Yan, Dong-wang|Tang, Hua-mei|Peng, Zhi-hai|Yu, Zhen-hai
PMID: 22851081
Journal: J BUON. 2013 Jul-Sep;18(3):695-702.
Title: KLF4 expression and apoptosis-related markers in gastric cancer.
Author: Krstic, M|Stojnev, S|Jovanovic, L|Marjanovic, G
PMID: 24065485
Journal: Asian Pac J Cancer Prev. 2014;15(18):7747-52.
Title: Synergistic anti-tumor effect of KLF4 and curcumin in human gastric carcinoma cell line.
Author: Ji, Jun|Wang, He-Shuang|Gao, Yan-Yan|Sang, Li-Min|Zhang, Li
PMID: 25292057
Journal: Cell Biosci. 2014 May 5;4:26.
Title: MicroRNA-206 suppresses gastric cancer cell growth and metastasis.
Author: Ren, Jun|Huang, Hui-Jie|Gong, Yu|Yue, Shen|Tang, Li-Ming|Cheng, Steven Y
PMID: 24855559
Journal: Cell Stress Chaperones. 2014 Mar;19(2):217-26.
Title: Epigallocatechin-3-gallate regulates the expression of Kruppel-like factor 4 through myocyte enhancer factor 2A.
Author: Ma, Yuwen|Shi, Youkui|Li, Wenmei|Sun, Aijuan|Zang, Ping|Zhang, Peirong
PMID: 23884787
Journal: Tumour Biol. 2014 Jul;35(7):7177-85.
Title: Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric adenocarcinoma.
Author: Asadi, Malek Hossein|Derakhshani, Ali|Mowla, Seyed Javad
PMID: 24763828
Journal: Biochem Biophys Res Commun. 2015 Nov 27;467(4):913-20.
Title: MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4.
Author: Yan, Chao|Yu, Jianchun|Liu, Yuqin|Kang, Weiming|Ma, Zhiqiang|Zhou, Li
PMID: 26471298
Journal: Drug Des Devel Ther. 2015 Oct 9;9:5579-90.
Title: Arsenic sulfide inhibits cell migration and invasion of gastric cancer in vitro and in vivo.
Author: Zhang, Lian|Kim, Sungkyoung|Ding, Wenping|Tong, Yingying|Zhang, Xiuli|Pan, Minggui|Chen, Siyu
PMID: 26487802
Journal: Int J Mol Med. 2015 Dec;36(6):1657-63.
Title: Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells.
Author: Wen, Zhenzhen|Feng, Shujiong|Wei, Lijuan|Wang, Zhimin|Hong, Defei|Wang, Qiang
PMID: 26497016
Journal: Cancer Cell Int. 2015 Dec 12;15:115.
Title: Bioinformatics identification of potentially involved microRNAs in Tibetan with gastric cancer based on microRNA profiling.
Author: Luo, Yushuang|Zhang, Chengwu|Tang, Feng|Zhao, Junhui|Shen, Cunfang|Wang, Cheng|Yu, Pengjie|Wang, Miaozhou|Li, Yan|Di, J I|Chen, Rong|Rili, Ge
PMID: 26692821
Journal: Oncogene. 2016 Oct 27;35(43):5619-5628.
Title: All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth.
Author: Nguyen, P H|Giraud, J|Staedel, C|Chambonnier, L|Dubus, P|Chevret, E|Boeuf, H|Gauthereau, X|Rousseau, B|Fevre, M|Soubeyran, I|Belleannee, G|Evrard, S|Collet, D|Megraud, F|Varon, C
PMID: 27157616
Journal: Cell Death Dis. 2016 Jun 9;7(6):e2255.
Title: KLF4 deletion alters gastric cell lineage and induces MUC2 expression.
Author: Yu, T|Chen, X|Lin, T|Liu, J|Li, M|Zhang, W|Xu, X|Zhao, W|Liu, M|Napier, D L|Wang, C|Evers, B M|Liu, C
PMID: 27277677
Journal: Oncotarget. 2017 Sep 18;8(56):95542-95553.
Title: Long noncoding RNA LINC00673 epigenetically suppresses KLF4 by interacting with EZH2 and DNMT1 in gastric cancer.
Author: Ba, Ming-Chen|Long, Hui|Cui, Shu-Zhong|Gong, Yuan-Feng|Yan, Zhao-Fei|Wu, Yin-Bing|Tu, Yi-Nuo
PMID: 29221147
Journal: Am J Transl Res. 2017 Jun 15;9(6):3027-3036. eCollection 2017.
Title: KLF16 promotes proliferation in gastric cancer cells via regulating p21 and CDK4.
Author: Ma, Pei|Sun, Chong-Qi|Wang, Yan-Fen|Pan, Yu-Tian|Chen, Qin-Nan|Liu, Wei-Tao|Liu, Jie|Zhao, Chen-Hui|Shu, Yong-Qian|Li, Wei
PMID: 28670390
Journal: Oncol Lett. 2017 Feb;13(2):819-826.
Title: Prognostic significance of KLF4 expression in gastric cancer.
Author: Hashimoto, Isaya|Nagata, Takuya|Sekine, Shinichi|Moriyama, Makoto|Shibuya, Kazuto|Hojo, Shozo|Matsui, Koshi|Yoshioka, Isaku|Okumura, Tomoyuki|Hori, Takashi|Shimada, Yutaka|Tsukada, Kazuhiro
PMID: 28356964
Journal: Clin Cancer Res. 2018 May 15;24(10):2440-2451.
Title: Kruppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
Author: Kong, Fanyang|Sun, Tao|Kong, Xiangyu|Xie, Dacheng|Li, Zhaoshen|Xie, Keping
PMID: 28719351
Journal: Clin Cancer Res. 2018 May 15;24(10):2440-2451.
Title: Kruppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
Author: Kong, Fanyang|Sun, Tao|Kong, Xiangyu|Xie, Dacheng|Li, Zhaoshen|Xie, Keping
PMID: 29367428
Journal: Cell Biol Int. 2018 Aug;42(8):949-958.
Title: Ibuprofen reduces cell proliferation through inhibiting Wnt/beta catenin signaling pathway in gastric cancer stem cells.
Author: Akrami, Hassan|Moradi, Behrouz|Borzabadi Farahani, Diba|Mehdizadeh, Kiumars
PMID: 29512256
Journal: Oncotarget. 2017 Nov 20;9(15):12471-12478.
Title: Research progress on the forkhead box C1.
Author: Wang, Jinhua|Li, Wan|Zheng, Xiangjin|Pang, Xiaocong|Du, Guanhua
PMID: 29552326
Journal: Oncotarget. 2018 Apr 6;9(26):18386-18399.
Title: Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer.
Author: Arun, Kanagaraj|Arunkumar, Ganesan|Bennet, Duraisamy|Chandramohan, Servarayan Murugesan|Murugan, Avaniyapuram Kannan|Munirajan, Arasambattu Kannan
PMID: 29719612
Journal: Gastric Cancer. 2018 May 10. pii: 10.1007/s10120-018-0833-y.
Title: PODXL, negatively regulated by KLF4, promotes the EMT and metastasis and serves as a novel prognostic indicator of gastric cancer.
Author: Zhang, Jing|Zhu, Zhonglin|Wu, Huijing|Yu, Zhilong|Rong, Zeyin|Luo, Zai|Xu, Yiwei|Huang, Kejian|Qiu, Zhengjun|Huang, Chen
PMID: 29748877
Journal: Oncol Lett. 2018 May;15(5):6865-6872.
Title: Role of Kruppel-like factor 4 in regulating inhibitor of apoptosis-stimulating protein of p53 in the progression of gastric cancer.
Author: Wang, Lulu|Li, Yan|Li, Luchun|Wu, Zhijuan|Wu, Yongzhong|Ma, Huiwen|Yu, Huiqing|Yang, Dan|Wang, Donglin
PMID: 29849786
Journal: Dig Dis Sci. 2018 Oct;63(10):2604-2616.
Title: Negative Regulation of Kruppel-Like Factor 4 on microRNA-106a at Upstream Transcriptional Level and the Role in Gastric Cancer Metastasis.
Author: Zhu, Meng|Zhang, Ning|Lu, Xinlan|He, Shuixiang
PMID: 29948558
Journal: FASEB J. 2018 Jul 9:fj201701456RR.
Title: Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer.
Author: Shao, Linlin|Chen, Zheng|Soutto, Mohammed|Zhu, Shoumin|Lu, Heng|Romero-Gallo, Judith|Peek, Richard|Zhang, Shutian|El-Rifai, Wael
PMID: 29985646