Primary Site >> Colorectal Cancer

Gene >> KITLG

Journal: Tumour Biol. 1993;14(5):295-302.
Title: Expression of c-kit and kit ligand in human colon carcinoma cells.
Author: Toyota, M|Hinoda, Y|Takaoka, A|Makiguchi, Y|Takahashi, T|Itoh, F|Imai, K|Yachi, A
PMID: 7694350
Journal: Int J Cancer. 1994 May 1;57(3):330-5.
Title: Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients.
Author: Juhl, H|Stritzel, M|Wroblewski, A|Henne-Bruns, D|Kremer, B|Schmiegel, W|Neumaier, M|Wagener, C|Schreiber, H W|Kalthoff, H
PMID: 8168992
Journal: Cell Growth Differ. 1995 Sep;6(9):1111-8.
Title: Interleukin 4 down-regulates expression of c-kit and autocrine stem cell factor in human colorectal carcinoma cells.
Author: Lahm, H|Amstad, P|Yilmaz, A|Borbenyi, Z|Wyniger, J|Fischer, J R|Suardet, L|Givel, J C|Odartchenko, N
PMID: 8519688
Journal: J Cell Physiol. 1997 Jul;172(1):1-11.
Title: Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-beta 1.
Author: Bellone, G|Silvestri, S|Artusio, E|Tibaudi, D|Turletti, A|Geuna, M|Giachino, C|Valente, G|Emanuelli, G|Rodeck, U
PMID: 9207920
Journal: Ann Oncol. 1998 Feb;9(2):173-80.
Title: High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: a phase II and pharmacodynamic study.
Author: Rowinsky, E K|Baker, S D|Burks, K|O'Reilly, S|Donehower, R C|Grochow, L B
PMID: 9553662
Journal: Oncology. 1999 Nov;57(4):276-80.
Title: Clinical implications of lymph node micrometastases in patients with colorectal cancers. A case control study.
Author: Nakanishi, Y|Ochiai, A|Yamauchi, Y|Moriya, Y|Yoshimura, K|Hirohashi, S
PMID: 10575311
Journal: Mol Carcinog. 2001 Jan;30(1):62-70.
Title: Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but antisense SAG transfection inhibits tumor cell growth.
Author: Huang, Y|Duan, H|Sun, Y
PMID: 11255265
Journal: Cancer Res. 2001 Mar 1;61(5):2200-6.
Title: Aberrant activation of c-kit protects colon carcinoma cells against apoptosis and enhances their invasive potential.
Author: Bellone, G|Carbone, A|Sibona, N|Bosco, O|Tibaudi, D|Smirne, C|Martone, T|Gramigni, C|Camandona, M|Emanuelli, G|Rodeck, U
PMID: 11280787
Journal: World J Gastroenterol. 2002 Aug;8(4):619-23.
Title: Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells.
Author: Nie, Yong-Zhan|He, Feng-Tian|Li, Zhi-Kui|Wu, Kai-Chun|Cao, Yun-Xin|Chen, Bao-Jun|Fan, Dai-Ming
PMID: 12174367
Journal: Clin Colorectal Cancer. 2002 Aug;2(2):119-22.
Title: Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinoma.
Author: Reed, Jennifer|Ouban, Abderrahman|Schickor, Frank K|Muraca, Patrick|Yeatman, Timothy|Coppola, Domenico
PMID: 12453327
Journal: BMC Mol Biol. 2003 Sep 29;4:10.
Title: A protein knockdown strategy to study the function of beta-catenin in tumorigenesis.
Author: Cong, Feng|Zhang, Jianxuan|Pao, William|Zhou, Pengbo|Varmus, Harold
PMID: 14516475
Journal: Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12729-34. Epub 2003 Oct 16.
Title: Eradication of pathogenic beta-catenin by Skp1/Cullin/F box ubiquitination machinery.
Author: Su, Yunyun|Ishikawa, Shinji|Kojima, Masayuki|Liu, Bo
PMID: 14563921
Journal: Am Surg. 2004 Apr;70(4):347-51.
Title: Body fat accumulation and postoperative complications after abdominal surgery.
Author: Tsukada, Katsuhiko|Miyazaki, Tatsuya|Kato, Hiroyuki|Masuda, Norihiro|Fukuchi, Minoru|Fukai, Yasuyuki|Nakajima, Masanobu|Ishizaki, Masatoshi|Motegi, Masahiko|Mogi, Akira|Sohda, Makoto|Moteki, Takao|Sekine, Tomoaki|Kuwano, Hiroyuki
PMID: 15098790
Journal: Nature. 2006 Jun 15;441(7095):898-901.
Title: CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.
Author: Noubissi, Felicite K|Elcheva, Irina|Bhatia, Neehar|Shakoori, Abbas|Ougolkov, Andrei|Liu, Jianghuai|Minamoto, Toshinari|Ross, Jeff|Fuchs, Serge Y|Spiegelman, Vladimir S
PMID: 16778892
Journal: Int J Oncol. 2006 Oct;29(4):851-9.
Title: KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes.
Author: Bellone, Graziella|Smirne, Carlo|Carbone, Anna|Buffolino, Alessandra|Scirelli, Tiziana|Prati, Adriana|Solerio, Dino|Pirisi, Mario|Valente, Guido|Nano, Mario|Emanuelli, Giorgio
PMID: 16964380
Journal: Int J Cancer. 2006 Feb 1;118(3):755-64.
Title: Monitoring multiple angiogenesis-related molecules in the blood of cancer patients shows a correlation between VEGF-A and MMP-9 levels before treatment and divergent changes after surgical vs. conservative therapy.
Author: Zaman, Khalil|Driscoll, Robert|Hahn, Diane|Werffeli, Patricia|Goodman, Simon L|Bauer, Jean|Leyvraz, Serge|Lejeune, Ferdy|Stupp, Roger|Ruegg, Curzio
PMID: 16114015
Journal: Int J Colorectal Dis. 2007 Jan;22(1):33-8.
Title: Pretreatment serum levels of hematopoietic cytokines in patients with colorectal adenomas and cancer.
Author: Mroczko, Barbara|Szmitkowski, Maciej|Wereszczynska-Siemiatkowska, Urszula|Okulczyk, Bogna|Kedra, Boguslaw
PMID: 16520929
Journal: Biochem Biophys Res Commun. 2007 Mar 23;354(4):992-8.
Title: The FBXW7 beta-form is suppressed in human glioma cells.
Author: Gu, Zhaodi|Inomata, Kenichi|Ishizawa, Kota|Horii, Akira
PMID: 17274947
Journal: Dig Dis Sci. 2007 Sep;52(9):2292-300. Epub 2007 Apr 5.
Title: Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway.
Author: Yasuda, Akira|Sawai, Hirozumi|Takahashi, Hiroki|Ochi, Nobuo|Matsuo, Yoichi|Funahashi, Hitoshi|Sato, Mikinori|Okada, Yuji|Takeyama, Hiromitsu|Manabe, Tadao
PMID: 17410437
Journal: Cancer Lett. 2008 May 18;263(2):197-203.
Title: Effects of adjuvant chemotherapy on bone marrow mesenchymal stem cells of colorectal cancer patients.
Author: Cao, J|Tan, M H|Yang, P|Li, W L|Xia, J|Du, H|Tang, W B|Wang, H|Chen, X W|Xiao, H Q
PMID: 18304729
Journal: J Biochem. 2009 Mar;145(3):289-97.
Title: Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.
Author: Yang, Xiaoming|Wood, Patricia A|Ansell, Christine M|Ohmori, Masami|Oh, Eun-Yeong|Xiong, Yin|Berger, Franklin G|Pena, Maria Marjorette O|Hrushesky, William J M
PMID: 19106159
Journal: Neoplasia. 2009 Apr;11(4):355-64.
Title: Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo.
Author: van der Horst, Edward Htun|Chinn, Lawrence|Wang, Min|Velilla, Timothy|Tran, Hoang|Madrona, Yarrow|Lam, Andrew|Ji, May|Hoey, Timothy C|Sato, Aaron K
PMID: 19308290
Journal: Mol Cell Biol. 2009 Dec;29(23):6192-205.
Title: beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.
Author: Li, Xin|Liu, Jianyu|Gao, Tianyan
PMID: 19797085
Journal: Mol Carcinog. 2010 Feb;49(2):121-9.
Title: Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma.
Author: Lauscher, Johannes C|Grone, Jorn|Dullat, Sonja|Hotz, Birgit|Ritz, Jorg-P|Steinhoff, Ulrich|Buhr, Heinz-J|Visekruna, Alexander
PMID: 20027638
Journal: Nature. 2011 Mar 3;471(7336):104-9.
Title: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Author: Inuzuka, Hiroyuki|Shaik, Shavali|Onoyama, Ichiro|Gao, Daming|Tseng, Alan|Maser, Richard S|Zhai, Bo|Wan, Lixin|Gutierrez, Alejandro|Lau, Alan W|Xiao, Yonghong|Christie, Amanda L|Aster, Jon|Settleman, Jeffrey|Gygi, Steven P|Kung, Andrew L|Look, Thomas|Nakay
PMID: 21368833
Journal: J Exp Med. 2011 Feb 14;208(2):295-312.
Title: FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
Author: Babaei-Jadidi, Roya|Li, Ningning|Saadeddin, Anas|Spencer-Dene, Bradley|Jandke, Anett|Muhammad, Belal|Ibrahim, ElSayed E|Muraleedharan, Ranjithmenon|Abuzinadah, Mohammed|Davis, Hayley|Lewis, Annabelle|Watson, Susan|Behrens, Axel|Tomlinson, Ian|Nateri, Abdo
PMID: 21282377
Journal: Cytokine. 2011 Feb;53(2):243-8.
Title: The perioperative granulocyte/lymphocyte ratio is a clinically relevant marker of surgical stress in patients with colorectal cancer.
Author: Tabuchi, Takanobu|Shimazaki, Jiro|Satani, Tetsuro|Nakachi, Takeshi|Watanabe, Yoshinori|Tabuchi, Takafumi
PMID: 21094053
Journal: PLoS One. 2012;7(2):e31284.
Title: Defining components of the ss-catenin destruction complex and exploring its regulation and mechanisms of action during development.
Author: Roberts, David M|Pronobis, Mira I|Alexandre, Kelly M|Rogers, Gregory C|Poulton, John S|Schneider, Daniel E|Jung, Kuo-Chen|McKay, Daniel J|Peifer, Mark
PMID: 22359584
Journal: Organometallics. 2012 May 14;31(9):3519-3526.
Title: Anticancer Activity of Self-Assembled Molecular Rectangles via Arene-Ruthenium Acceptors and a New Unsymmetrical Amide Ligand.
Author: Mishra, Anurag|Jung, Hyunji|Park, Jeong Woo|Kim, Hong Kyeung|Kim, Hyunuk|Stang, Peter J|Chi, Ki-Whan
PMID: 22639481
Journal: Clin Cancer Res. 2013 Sep 15;19(18):4961-71.
Title: Protein kinase C-delta-mediated recycling of active KIT in colon cancer.
Author: Park, Misun|Kim, Won Kyu|Song, Meiying|Park, Minhee|Kim, Hyunki|Nam, Hye Jin|Baek, Sung Hee|Kim, Hoguen
PMID: 23881925
Journal: Oncotarget. 2013 Sep;4(9):1399-415.
Title: Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness.
Author: Siemens, Helge|Jackstadt, Rene|Kaller, Markus|Hermeking, Heiko
PMID: 24009080
Journal: J Biol Chem. 2014 Mar 14;289(11):7730-7.
Title: Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.
Author: D'Annibale, Sara|Kim, Jihoon|Magliozzi, Roberto|Low, Teck Yew|Mohammed, Shabaz|Heck, Albert J R|Guardavaccaro, Daniele
PMID: 24500709
Journal: J Cell Mol Med. 2014 Oct;18(10):2092-102.
Title: KITLG is a novel target of miR-34c that is associated with the inhibition of growth and invasion in colorectal cancer cells.
Author: Yang, Shu|Li, Wen-shuai|Dong, Fang|Sun, Hai-mei|Wu, Bo|Tan, Jun|Zou, Wan-jing|Zhou, De-shan
PMID: 25213795
Journal: BMC Cancer. 2015 Dec 16;15:969.
Title: Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo.
Author: Yang, Shu|Li, Wenshuai|Sun, Haimei|Wu, Bo|Ji, Fengqing|Sun, Tingyi|Chang, Huanhuan|Shen, Ping|Wang, Yaxi|Zhou, Deshan
PMID: 26674205
Journal: Biosci Rep. 2015 Dec 24;36(1):e00293.
Title: Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation.
Author: Yang, Shu|Wu, Bo|Sun, Haimei|Ji, Fengqing|Sun, Tingyi|Zhao, Yan|Zhou, Deshan
PMID: 26704889
Journal: Elife. 2015 Nov 27;4.
Title: Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.
Author: Vera, Jorge|Lartigue, Lydia|Vigneron, Suzanne|Gadea, Gilles|Gire, Veronique|Del Rio, Maguy|Soubeyran, Isabelle|Chibon, Frederic|Lorca, Thierry|Castro, Anna
PMID: 26613407
Journal: Drug Deliv Transl Res. 2015 Dec;5(6):596-610.
Title: Coated chitosan nanoparticles encapsulating caspase 3 activator for effective treatment of colorectral cancer.
Author: Jain, Aakanchha|Jain, Sourabh|Jain, Richa|Kohli, Dharm Veer
PMID: 26334865
Journal: J Gastrointestin Liver Dis. 2015 Jun;24(2):225-34.
Title: The role of Skp2 and its substrate CDKN1B (p27) in colorectal cancer.
Author: Bochis, Ovidiu V|Irimie, Alexandru|Pichler, Martin|Berindan-Neagoe, Ioana
PMID: 26114183
Journal: Gastroenterology. 2015 Sep;149(3):705-17.e2.
Title: KIT Signaling Promotes Growth of Colon Xenograft Tumors in Mice and Is Up-Regulated in a Subset of Human Colon Cancers.
Author: Chen, Evan C|Karl, Taylor A|Kalisky, Tomer|Gupta, Santosh K|O'Brien, Catherine A|Longacre, Teri A|van de Rijn, Matt|Quake, Stephen R|Clarke, Michael F|Rothenberg, Michael E
PMID: 26026391
Journal: Gastroenterology. 2015 Sep;149(3):692-704.
Title: Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells.
Author: Fatrai, Szabolcs|van Schelven, Susanne J|Ubink, Inge|Govaert, Klaas M|Raats, Danielle|Koster, Jan|Verheem, Andre|Borel Rinkes, Inne H M|Kranenburg, Onno
PMID: 25962936
Journal: Appl Microbiol Biotechnol. 2016 Jan;100(1):263-77.
Title: Targeting c-kit receptor in neuroblastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxins.
Author: Choudhary, Swati|Pardo, Alessa|Rosinke, Reinhard|Batra, Janendra K|Barth, Stefan|Verma, Rama S
PMID: 26428235
Journal: Cancer Res. 2016 Jan 15;76(2):347-57.
Title: Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation.
Author: Kasagi, Yuta|Harada, Yui|Morodomi, Yosuke|Iwai, Toshiki|Saito, Satoru|Yoshida, Kumi|Oki, Eiji|Saeki, Hiroshi|Ohgaki, Kippei|Sugiyama, Masahiko|Onimaru, Mitsuho|Maehara, Yoshihiko|Yonemitsu, Yoshikazu
PMID: 26744523
Journal: Cancer Lett. 2017 Mar 1;388:85-95.
Title: FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma.
Author: Wang, F F|Zhang, X J|Yan, Y R|Zhu, X H|Yu, J|Ding, Y|Hu, J L|Zhou, W J|Zeng, Z C|Liao, W T|Ding, Y Q|Liang, L
PMID: 27916606
Journal: Carbohydr Polym. 2017 Feb 10;157:1503-1510.
Title: Structural features and anticancer activity in vitro of fucoidan derivatives from brown alga Saccharina cichorioides.
Author: Anastyuk, Stanislav D|Shevchenko, Natalia M|Usoltseva Menshova, Roza V|Silchenko, Artyom S|Zadorozhny, Pavel A|Dmitrenok, Pavel S|Ermakova, Svetlana P
PMID: 27987862
Journal: Molecules. 2017 Mar 30;22(4). pii: molecules22040561.
Title: Novel Palladium(II) Complexes that Influence Prominin-1/CD133 Expression and Stem Cell Factor Release in Tumor Cells.
Author: Fischer-Fodor, Eva|Miklas, Roman|Risianova, Lucia|Cenariu, Mihai|Grosu, Ioana-Georgeta|Virag, Piroska|Perde-Schrepler, Maria|Tomuleasa, Ciprian|Berindan-Neagoe, Ioana|Devinsky, Ferdinand|Miklasova, Natalia
PMID: 28358339
Journal: Int J Mol Sci. 2017 Apr 6;18(4). pii: ijms18040765.
Title: SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma.
Author: Wang, Yaxi|Sun, Tingyi|Sun, Haimei|Yang, Shu|Li, Dandan|Zhou, Deshan
PMID: 28383479
Journal: J Recept Signal Transduct Res. 2018 Feb;38(1):1-11.
Title: Identifying novel small molecule antagonists for mLST8 protein using computational approaches.
Author: Sapam, Tuleshwori Devi|Velmurugan Ilavarasi, Anbumani|Palaka, Bhagath Kumar|Elumalai, Elakkiya|Kanika, Nirmala Devi|Ampasala, Dinakara Rao
PMID: 29041842
Journal: Am J Cancer Res. 2018 Jun 1;8(6):1064-1073. eCollection 2018.
Title: SCF/c-KIT signaling promotes mucus secretion of colonic goblet cells and development of mucinous colorectal adenocarcinoma.
Author: Li, Guilan|Yang, Shu|Shen, Ping|Wu, Bo|Sun, Tingyi|Sun, Haimei|Ji, Fengqing|Zhou, Deshan
PMID: 30034943
Journal: Evid Based Complement Alternat Med. 2018 Sep 12;2018:5149436.
Title: (+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer.
Author: Wu, Wei|Hou, Bing|Tang, Changli|Liu, Fucheng|Yang, Jie|Pan, Tao|Si, Ke|Lu, Deyun|Wang, Xiaoxiang|Wang, Jing|Xiong, Xing|Liu, Ji|Xie, Chunguang
PMID: 30298093
Journal: Oncoimmunology. 2018 Aug 24;7(11):e1504729.
Title: Human mast cells promote colon cancer growth via bidirectional crosstalk: studies in 2D and 3D coculture models.
Author: Yu, Yingxin|Blokhuis, Bart|Derks, Yvonne|Kumari, Sangeeta|Garssen, Johan|Redegeld, Frank
PMID: 30377568