Primary Site >> Liver Cancer
Gene >> KEAP1
| 1. | |||||||||||
| Journal: | Biochem J. 2004 Jun 1;380(Pt 2):515-21. | ||||||||||
| Title: | Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis. | ||||||||||
| Author: | Ikeda, Hiromi|Nishi, Shinzo|Sakai, Masaharu | ||||||||||
| PMID: | 14960151 | ||||||||||
| 2. | |||||||||||
| Journal: | Med Hypotheses. 2008 Nov;71(5):730-6. | ||||||||||
| Title: | The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver. | ||||||||||
| Author: | Tao, Kai-Shan|Wang, Wen|Wang, Ling|Cao, Da-Yong|Li, Yong-Qi|Wu, Sheng-Xi|Dou, Ke-Feng | ||||||||||
| PMID: | 18701223 | ||||||||||
| 3. | |||||||||||
| Journal: | Chem Res Toxicol. 2010 Sep 20;23(9):1477-84. | ||||||||||
| Title: | Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. | ||||||||||
| Author: | Gan, Nanqin|Sun, Xiaoyun|Song, Lirong | ||||||||||
| PMID: | 20722399 | ||||||||||
| 4. | |||||||||||
| Journal: | Nat Cell Biol. 2010 Mar;12(3):213-23. | ||||||||||
| Title: | The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. | ||||||||||
| Author: | Komatsu, Masaaki|Kurokawa, Hirofumi|Waguri, Satoshi|Taguchi, Keiko|Kobayashi, Akira|Ichimura, Yoshinobu|Sou, Yu-Shin|Ueno, Izumi|Sakamoto, Ayako|Tong, Kit I|Kim, Mihee|Nishito, Yasumasa|Iemura, Shun-ichiro|Natsume, Tohru|Ueno, Takashi|Kominami, Eiki|Motoh | ||||||||||
| PMID: | 20173742 | ||||||||||
| 5. | |||||||||||
| Journal: | J Cell Biol. 2011 Apr 18;193(2):275-84. | ||||||||||
| Title: | Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. | ||||||||||
| Author: | Inami, Yoshihiro|Waguri, Satoshi|Sakamoto, Ayako|Kouno, Tsuguka|Nakada, Kazuto|Hino, Okio|Watanabe, Sumio|Ando, Jin|Iwadate, Manabu|Yamamoto, Masayuki|Lee, Myung-Shik|Tanaka, Keiji|Komatsu, Masaaki | ||||||||||
| PMID: | 21482715 | ||||||||||
| 6. | |||||||||||
| Journal: | Toxicology. 2012 Sep 28;299(2-3):69-79. | ||||||||||
| Title: | Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1). | ||||||||||
| Author: | Gross-Steinmeyer, Kerstin|Eaton, David L | ||||||||||
| PMID: | 22640941 | ||||||||||
| 7. | |||||||||||
| Journal: | Hepatology. 2013 Nov;58(5):1693-702. | ||||||||||
| Title: | Identification of driver genes in hepatocellular carcinoma by exome sequencing. | ||||||||||
| Author: | Cleary, Sean P|Jeck, William R|Zhao, Xiaobei|Chen, Kui|Selitsky, Sara R|Savich, Gleb L|Tan, Ting-Xu|Wu, Michael C|Getz, Gad|Lawrence, Michael S|Parker, Joel S|Li, Jinyu|Powers, Scott|Kim, Hyeja|Fischer, Sandra|Guindi, Maha|Ghanekar, Anand|Chiang, Derek Y | ||||||||||
| PMID: | 23728943 | ||||||||||
| 8. | |||||||||||
| Journal: | J Cell Sci. 2013 Dec 15;126(Pt 24):5657-69. | ||||||||||
| Title: | Oncogene PKCepsilon controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2. | ||||||||||
| Author: | Niture, Suryakant K|Gnatt, Averell|Jaiswal, Anil K | ||||||||||
| PMID: | 24127568 | ||||||||||
| 9. | |||||||||||
| Journal: | World J Gastroenterol. 2013 Dec 21;19(47):8873-9. | ||||||||||
| Title: | Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. | ||||||||||
| Author: | Gu, De-Leung|Chen, Yen-Hsieh|Shih, Jou-Ho|Lin, Chi-Hung|Jou, Yuh-Shan|Chen, Chian-Feng | ||||||||||
| PMID: | 24379610 | ||||||||||
| 10. | |||||||||||
| Journal: | Acta Neuropathol Commun. 2014 May 3;2:50. | ||||||||||
| Title: | Phosphorylation of serine 349 of p62 in Alzheimer's disease brain. | ||||||||||
| Author: | Tanji, Kunikazu|Miki, Yasuo|Ozaki, Taku|Maruyama, Atsushi|Yoshida, Hidemi|Mimura, Junsei|Matsumiya, Tomoh|Mori, Fumiaki|Imaizumi, Tadaatsu|Itoh, Ken|Kakita, Akiyoshi|Takahashi, Hitoshi|Wakabayashi, Koichi | ||||||||||
| PMID: | 24886973 | ||||||||||
| 11. | |||||||||||
| Journal: | Eur J Pharmacol. 2014 Oct 15;741:247-53. | ||||||||||
| Title: | Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression. | ||||||||||
| Author: | Cho, Jong-Ho|Kim, Young-Woo|Choi, Bu Young|Keum, Young-Sam | ||||||||||
| PMID: | 25169428 | ||||||||||
| 12. | |||||||||||
| Journal: | J Hepatol. 2014 Dec;61(6):1312-20. | ||||||||||
| Title: | The genomic landscape of hepatoblastoma and their progenies with HCC-like features. | ||||||||||
| Author: | Eichenmuller, Melanie|Trippel, Franziska|Kreuder, Michaela|Beck, Alexander|Schwarzmayr, Thomas|Haberle, Beate|Cairo, Stefano|Leuschner, Ivo|von Schweinitz, Dietrich|Strom, Tim M|Kappler, Roland | ||||||||||
| PMID: | 25135868 | ||||||||||
| 13. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2014 Jul;7(7):653-7. | ||||||||||
| Title: | Of mice, rats, and men: could Nrf2 activation protect against aflatoxin heptocarcinogenesis in humans? | ||||||||||
| Author: | Eaton, David L|Schaupp, Christopher M | ||||||||||
| PMID: | 24934619 | ||||||||||
| 14. | |||||||||||
| Journal: | Antioxid Redox Signal. 2014 Dec 20;21(18):2498-514. | ||||||||||
| Title: | The PTEN/NRF2 axis promotes human carcinogenesis. | ||||||||||
| Author: | Rojo, Ana I|Rada, Patricia|Mendiola, Marta|Ortega-Molina, Ana|Wojdyla, Katarzyna|Rogowska-Wrzesinska, Adelina|Hardisson, David|Serrano, Manuel|Cuadrado, Antonio | ||||||||||
| PMID: | 24892215 | ||||||||||
| 15. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2014 Jul;7(7):658-65. | ||||||||||
| Title: | Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. | ||||||||||
| Author: | Johnson, Natalie M|Egner, Patricia A|Baxter, Victoria K|Sporn, Michael B|Wible, Ryan S|Sutter, Thomas R|Groopman, John D|Kensler, Thomas W|Roebuck, Bill D | ||||||||||
| PMID: | 24662598 | ||||||||||
| 16. | |||||||||||
| Journal: | Hepatology. 2014 Jun;59(6):2371-82. | ||||||||||
| Title: | NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice. | ||||||||||
| Author: | Shirasaki, Keiichi|Taguchi, Keiko|Unno, Michiaki|Motohashi, Hozumi|Yamamoto, Masayuki | ||||||||||
| PMID: | 24443206 | ||||||||||
| 17. | |||||||||||
| Journal: | Cell Death Dis. 2015 Nov 19;6:e1980. | ||||||||||
| Title: | Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation. | ||||||||||
| Author: | Liu, B|Fang, M|He, Z|Cui, D|Jia, S|Lin, X|Xu, X|Zhou, T|Liu, W | ||||||||||
| PMID: | 26583321 | ||||||||||
| 18. | |||||||||||
| Journal: | Hepatobiliary Pancreat Dis Int. 2015 Oct;14(5):485-91. | ||||||||||
| Title: | Liver expression of Nrf2-related genes in different liver diseases. | ||||||||||
| Author: | Cheng, Ming-Liang|Lu, Yuan-Fu|Chen, Hong|Shen, Zhong-Yang|Liu, Jie | ||||||||||
| PMID: | 26459724 | ||||||||||
| 19. | |||||||||||
| Journal: | Am J Cancer Res. 2015 Mar 15;5(4):1368-81. eCollection 2015. | ||||||||||
| Title: | Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma. | ||||||||||
| Author: | Sun, Chao|Wang, Zhen-Hua|Liu, Xiong-Xiong|Yang, Li-Na|Wang, Yali|Liu, Yang|Mao, Ai-Hong|Liu, Yuan-Yuan|Zhou, Xin|Di, Cui-Xia|Gan, Lu|Zhang, Hong | ||||||||||
| PMID: | 26101703 | ||||||||||
| 20. | |||||||||||
| Journal: | Gastroenterology. 2015 Oct;149(5):1226-1239.e4. | ||||||||||
| Title: | Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. | ||||||||||
| Author: | Zucman-Rossi, Jessica|Villanueva, Augusto|Nault, Jean-Charles|Llovet, Josep M | ||||||||||
| PMID: | 26099527 | ||||||||||
| 21. | |||||||||||
| Journal: | Cells. 2015 May 20;4(2):169-77. | ||||||||||
| Title: | What is Known Regarding the Participation of Factor Nrf-2 in Liver Regeneration? | ||||||||||
| Author: | Morales-Gonzalez, Jose A|Madrigal-Santillan, Eduardo|Morales-Gonzalez, Angel|Bautista, Mirandeli|Gayosso-Islas, Evila|Sanchez-Moreno, Cecilia | ||||||||||
| PMID: | 26010752 | ||||||||||
| 22. | |||||||||||
| Journal: | J Physiol Biochem. 2015 Jun;71(2):227-38. | ||||||||||
| Title: | The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression. | ||||||||||
| Author: | Krajka-Kuzniak, Violetta|Paluszczak, Jaroslaw|Szaefer, Hanna|Baer-Dubowska, Wanda | ||||||||||
| PMID: | 25800511 | ||||||||||
| 23. | |||||||||||
| Journal: | Hepatology. 2015 Sep;62(3):851-62. | ||||||||||
| Title: | Nrf2, but not beta-catenin, mutation represents an early event in rat hepatocarcinogenesis. | ||||||||||
| Author: | Zavattari, Patrizia|Perra, Andrea|Menegon, Silvia|Kowalik, Marta Anna|Petrelli, Annalisa|Angioni, Maria Maddalena|Follenzi, Antonia|Quagliata, Luca|Ledda-Columbano, Giovanna Maria|Terracciano, Luigi|Giordano, Silvia|Columbano, Amedeo | ||||||||||
| PMID: | 25783764 | ||||||||||
| 24. | |||||||||||
| Journal: | J Expo Sci Environ Epidemiol. 2015 May;25(3):256-63. | ||||||||||
| Title: | Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome. | ||||||||||
| Author: | Tanase, Anna-Maria|Marchio, Agnes|Dumitrascu, Traian|Dima, Simona|Herlea, Vlad|Oprisan, Gabriela|Dejean, Anne|Popescu, Irinel|Pineau, Pascal | ||||||||||
| PMID: | 24736102 | ||||||||||
| 25. | |||||||||||
| Journal: | Cell Physiol Biochem. 2015;35(6):2333-48. | ||||||||||
| Title: | MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil. | ||||||||||
| Author: | Shi, Liang|Wu, Lili|Chen, Zhanguo|Yang, Jianrong|Chen, Xiaofei|Yu, Fangyou|Zheng, Fang|Lin, Xiangyang | ||||||||||
| PMID: | 25896253 | ||||||||||
| 26. | |||||||||||
| Journal: | J Exp Med. 2016 May 2;213(5):859-75. | ||||||||||
| Title: | Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma. | ||||||||||
| Author: | Yang, Chun|Tan, Ye-Xiong|Yang, Guang-Zhen|Zhang, Jian|Pan, Yu-Fei|Liu, Chen|Fu, Jing|Chen, Yao|Ding, Zhi-Wen|Dong, Li-Wei|Wang, Hong-Yang | ||||||||||
| PMID: | 27091842 | ||||||||||
| 27. | |||||||||||
| Journal: | J Hepatobiliary Pancreat Sci. 2016 Aug;23(8):467-71. | ||||||||||
| Title: | Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma. | ||||||||||
| Author: | Shimizu, Takayuki|Inoue, Ken-Ichi|Hachiya, Hiroyuki|Shibuya, Norisuke|Aoki, Taku|Kubota, Keiichi | ||||||||||
| PMID: | 27246794 | ||||||||||
| 28. | |||||||||||
| Journal: | Cancer Med. 2016 Oct;5(10):2678-2687. | ||||||||||
| Title: | Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma. | ||||||||||
| Author: | Chen, Jiang|Yu, Yaojun|Ji, Tong|Ma, Rui|Chen, Mingming|Li, Gaofeng|Li, Feibo|Ding, Qiong|Kang, Qingsong|Huang, Diyu|Liang, Xiao|Lin, Hui|Cai, Xiujun | ||||||||||
| PMID: | 27650414 | ||||||||||
| 29. | |||||||||||
| Journal: | Cancer Res. 2017 Sep 15;77(18):4797-4808. | ||||||||||
| Title: | Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis. | ||||||||||
| Author: | Ngo, Hoang Kieu Chi|Kim, Do-Hee|Cha, Young-Nam|Na, Hye-Kyung|Surh, Young-Joon | ||||||||||
| PMID: | 28655791 | ||||||||||
| 30. | |||||||||||
| Journal: | Front Pharmacol. 2017 Nov 27;8:868. | ||||||||||
| Title: | Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells. | ||||||||||
| Author: | Sharath Babu, G R|Anand, Tamatam|Ilaiyaraja, N|Khanum, Farhath|Gopalan, N | ||||||||||
| PMID: | 29230174 | ||||||||||
| 31. | |||||||||||
| Journal: | J Pharm Pharmacol. 2018 Sep 25. | ||||||||||
| Title: | Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/MAPK and activating the Nrf2/ARE signalling pathways in HepG2 cells. | ||||||||||
| Author: | Ren, Jie|Yuan, Ling|Wang, Yue|Chen, Guangtong|Hu, Kun | ||||||||||
| PMID: | 30251384 | ||||||||||
| 32. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2018 Sep 6;358:1-9. | ||||||||||
| Title: | Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity. | ||||||||||
| Author: | Zhu, Jiayu|Wang, Huihui|Chen, Feng|Lv, Hang|Xu, Zijin|Fu, Jingqi|Hou, Yongyong|Xu, Yuanyuan|Pi, Jingbo | ||||||||||
| PMID: | 30196066 | ||||||||||
| 33. | |||||||||||
| Journal: | Evid Based Complement Alternat Med. 2018 Aug 16;2018:1549805. | ||||||||||
| Title: | Cytotoxic Effect of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) on Liver Cancer Cell Integrated with Hepatitis B Genome, Hep3B. | ||||||||||
| Author: | Haron, Aminah Suhaila|Syed Alwi, Sharifah Sakinah|Saiful Yazan, Latifah|Abd Razak, Rohaina|Ong, Yong Sze|Zakarial Ansar, Fatin Hannani|Roshini Alexander, Henna | ||||||||||
| PMID: | 30186351 | ||||||||||
| 34. | |||||||||||
| Journal: | Cell Commun Signal. 2018 Aug 17;16(1):47. | ||||||||||
| Title: | lncRNA KRAL reverses 5-fluorouracil resistance in hepatocellular carcinoma cells by acting as a ceRNA against miR-141. | ||||||||||
| Author: | Wu, Lili|Pan, Chenwei|Wei, Xin|Shi, Yifen|Zheng, Jianjian|Lin, Xiangyang|Shi, Liang | ||||||||||
| PMID: | 30119680 | ||||||||||
| 35. | |||||||||||
| Journal: | Theranostics. 2018 Jun 24;8(14):3891-3901. | ||||||||||
| Title: | Tumor-suppressing miR-141 gene complex-loaded tissue-adhesive glue for the locoregional treatment of hepatocellular carcinoma. | ||||||||||
| Author: | Kim, Min-Kyoung|Moon, Young-Ah|Song, Chung Kil|Baskaran, Rengarajan|Bae, Sijeong|Yang, Su-Geun | ||||||||||
| PMID: | 30083268 | ||||||||||
| 36. | |||||||||||
| Journal: | Yakugaku Zasshi. 2018;138(8):1059-1065. | ||||||||||
| Title: | [Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2]. | ||||||||||
| Author: | Yasuda, Daisuke|Obata, Rika|Takahashi, Kyoko|Ohe, Tomoyuki|Mashino, Tadahiko | ||||||||||
| PMID: | 30068847 | ||||||||||
| 37. | |||||||||||
| Journal: | J Hepatol. 2018 Sep;69(3):635-643. | ||||||||||
| Title: | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. | ||||||||||
| Author: | Orru, Claudia|Szydlowska, Marta|Taguchi, Keiko|Zavattari, Patrizia|Perra, Andrea|Yamamoto, Masayuki|Columbano, Amedeo | ||||||||||
| PMID: | 29758334 | ||||||||||
| 38. | |||||||||||
| Journal: | Life Sci. 2018 Apr 15;199:23-33. | ||||||||||
| Title: | Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). | ||||||||||
| Author: | Verma, Ajeet Kumar|Yadav, Arti|Singh, Sarvendra Vikram|Mishra, Pratibha|Rath, Srikanta Kumar | ||||||||||
| PMID: | 29499281 | ||||||||||
| 39. | |||||||||||
| Journal: | Pharmacol Ther. 2018 Jun;186:138-151. | ||||||||||
| Title: | CCRK is a novel signalling hub exploitable in cancer immunotherapy. | ||||||||||
| Author: | Mok, Myth T|Zhou, Jingying|Tang, Wenshu|Zeng, Xuezhen|Oliver, Antony W|Ward, Simon E|Cheng, Alfred S | ||||||||||
| PMID: | 29360538 | ||||||||||
| 40. | |||||||||||
| Journal: | Transl Res. 2018 Mar;193:54-71. | ||||||||||
| Title: | Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma. | ||||||||||
| Author: | Bartolini, Desiree|Dallaglio, Katiuscia|Torquato, Pierangelo|Piroddi, Marta|Galli, Francesco | ||||||||||
| PMID: | 29274776 | ||||||||||