Primary Site >> Liver Cancer
Gene >> KEAP1
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Ref: Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis. PMID: 14960151 |
Ref: The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver. PMID: 18701223 |
Ref: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. PMID: 20173742 Ref: Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. PMID: 20722399 |
Ref: Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. PMID: 21482715 |
Ref: Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1). PMID: 22640941 |
Ref: Identification of driver genes in hepatocellular carcinoma by exome sequencing. PMID: 23728943 Ref: Oncogene PKCepsilon controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2. PMID: 24127568 Ref: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID: 24379610 |
Ref: NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice. PMID: 24443206 Ref: Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. PMID: 24662598 Ref: Phosphorylation of serine 349 of p62 in Alzheimer's disease brain. PMID: 24886973 Ref: The PTEN/NRF2 axis promotes human carcinogenesis. PMID: 24892215 Ref: Of mice, rats, and men: could Nrf2 activation protect against aflatoxin heptocarcinogenesis in humans? PMID: 24934619 Ref: The genomic landscape of hepatoblastoma and their progenies with HCC-like features. PMID: 25135868 Ref: Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression. PMID: 25169428 |
Ref: Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome. PMID: 24736102 Ref: Nrf2, but not beta-catenin, mutation represents an early event in rat hepatocarcinogenesis. PMID: 25783764 Ref: The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression. PMID: 25800511 Ref: MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil. PMID: 25896253 Ref: What is Known Regarding the Participation of Factor Nrf-2 in Liver Regeneration? PMID: 26010752 Ref: Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. PMID: 26099527 Ref: Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma. PMID: 26101703 Ref: Liver expression of Nrf2-related genes in different liver diseases. PMID: 26459724 Ref: Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation. PMID: 26583321 |
Ref: Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma. PMID: 27091842 Ref: Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma. PMID: 27246794 Ref: Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma. PMID: 27650414 |
Ref: Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis. PMID: 28655791 Ref: Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells. PMID: 29230174 |
Ref: Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma. PMID: 29274776 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). PMID: 29499281 Ref: Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. PMID: 29758334 Ref: [Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2]. PMID: 30068847 Ref: Tumor-suppressing miR-141 gene complex-loaded tissue-adhesive glue for the locoregional treatment of hepatocellular carcinoma. PMID: 30083268 Ref: lncRNA KRAL reverses 5-fluorouracil resistance in hepatocellular carcinoma cells by acting as a ceRNA against miR-141. PMID: 30119680 Ref: Cytotoxic Effect of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) on Liver Cancer Cell Integrated with Hepatitis B Genome, Hep3B. PMID: 30186351 Ref: Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity. PMID: 30196066 Ref: Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/MAPK and activating the Nrf2/ARE signalling pathways in HepG2 cells. PMID: 30251384 |